acth-(4-7)--pro-gly-pro- and ubenimex

acth-(4-7)--pro-gly-pro- has been researched along with ubenimex* in 1 studies

Other Studies

1 other study(ies) available for acth-(4-7)--pro-gly-pro- and ubenimex

Article	Year
N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes. Biochemical and biophysical research communications, 1991, Apr-30, Volume: 176, Issue:2 Degradation of a regulatory peptide ACTH(4-10) and its synthetic analog semax in rat blood and serum was studied using high-performance liquid chromatography. About one third to one half of the serum degrading activity could be ascribed to bestatin-sensitive aminopeptidase which cleaved first and second N-terminal residues Met and Glu producing relatively stable intermediates. Comparable areas under the degradation/accumulation curves for intact peptides and intermediates implied that the latter can contribute to effects of intact peptides. Semax turned out to be more stable than ACTH(4-10) against the action of other enzymes that took part in degradation. Topics: Adrenocorticotropic Hormone; Animals; Chromatography, High Pressure Liquid; Hydrolysis; Leucine; Male; Peptide Fragments; Rats; Rats, Inbred Strains	1991

Article

Year

N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes.

Biochemical and biophysical research communications, 1991, Apr-30, Volume: 176, Issue:2

Degradation of a regulatory peptide ACTH(4-10) and its synthetic analog semax in rat blood and serum was studied using high-performance liquid chromatography. About one third to one half of the serum degrading activity could be ascribed to bestatin-sensitive aminopeptidase which cleaved first and second N-terminal residues Met and Glu producing relatively stable intermediates. Comparable areas under the degradation/accumulation curves for intact peptides and intermediates implied that the latter can contribute to effects of intact peptides. Semax turned out to be more stable than ACTH(4-10) against the action of other enzymes that took part in degradation.

Topics: Adrenocorticotropic Hormone; Animals; Chromatography, High Pressure Liquid; Hydrolysis; Leucine; Male; Peptide Fragments; Rats; Rats, Inbred Strains

1991