acrolein has been researched along with mesna in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (26.09) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Farquhar, D; Wang, YQ | 1 |
| Chen, R; Farquhar, D; Khan, S | 1 |
| Brock, N; Niemeyer, U; Pohl, J; Scheffler, G; Stekar, J | 1 |
| Chapman, MY; Holsapple, MP; Kawabata, TT; Kim, DH; Stevens, WD | 1 |
| Brock, N; Dietrich, I; Hilgard, P; Manz, I; Niemeyer, U; Pohl, J; Przybylski, M | 1 |
| Erexson, GL; Kligerman, AD; Wilmer, JL | 1 |
| Bos, RP; Niemeyer, U; Pool, BL; Schmähl, D; Theuws, JL | 1 |
| Bluth, U; Neubert, D; Stahlmann, R | 1 |
| Bryant, BM; Ford, HT; Jarman, M; Smith, IE | 1 |
| Allenbacher, A; Botzler, C; Issels, R; Meier, T; Mueller, E; Multhoff, G; Wiesnet, M | 1 |
| Boal, JH; Engel, J; Ho, CK; Ludeman, SM; Niemeyer, U | 1 |
| Dabrowiak, JC; Goodisman, J; Souid, AK; Tacka, KA | 1 |
| Grdina, DJ; Kataoka, Y; Murley, JS | 1 |
| Kojima, T; Sakura, N; Takamoto, S; Yashiki, M | 1 |
| Springate, JE; Taub, M; Zaki, EL | 1 |
| Springate, J; Taub, M | 1 |
| Batista, CK; Brito, GA; Cunha, FQ; Leitão, BT; Ribeiro, RA; Souza, ML | 1 |
| Korkmaz, A; Oter, S; Topal, T | 1 |
| Arai, T; Kitamura, D; Koyama, R; Mizuta, R; Yuasa, M | 1 |
| Averick, S; Beringer, LT; Gilmore, G; Li, S; Lister, J | 1 |
| Chai, Y; Dai, M; Fan, Z; Huang, F; Huang, H; Jiang, Q; Li, X; Liu, Q; Lu, Y; Mai, Q; Meng, F; Shen, K; Sun, J; Wei, Q; Xu, D; Xu, N; Yu, G; Zhang, Y; Zhao, H; Zhou, D; Zhou, H; Zhou, Y | 1 |
| Angara, B; Arditi, M; Bhowmick, NA; Dru, C; Duong, F; Fernandez, A; Haldar, S; Mishra, R; Tripathi, M | 1 |
| Beltran, MT; Jobson, J; Liu, Y; Rein, KS; Rein, SR; Taher, EA; Tsegay, PS | 1 |
2 review(s) available for acrolein and mesna
| Article | Year |
|---|---|
Radioprotectants: current status and new directions.
Topics: Acrolein; Amifostine; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Clinical Trials as Topic; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Heart; Humans; Mesna; Mutagenesis; Oxazines; Radiation-Protective Agents; Radiotherapy; Razoxane | 2002 |
Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation.
Topics: Acrolein; Antineoplastic Agents; Cell Death; Cyclophosphamide; Cystitis; Cytokines; DNA Damage; Enzyme Activation; Hemorrhage; Humans; Ifosfamide; Lipid Peroxidation; Mesna; Nitrogen; Oxygen; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Transcription Factors | 2007 |
2 trial(s) available for acrolein and mesna
| Article | Year |
|---|---|
Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma.
Topics: Acrolein; Carcinoma, Bronchogenic; Clinical Trials as Topic; Cyclophosphamide; Female; Hematuria; Humans; Ifosfamide; Kinetics; Lung Neoplasms; Male; Mercaptoethanol; Mesna; Phosphoramide Mustards; Urinary Bladder | 1980 |
Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine.
Topics: Acrolein; Adolescent; Adult; Aged; Allografts; Biotransformation; Child; Cyclophosphamide; Cystitis; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Hemorrhage; Histocompatibility; Humans; Incidence; Infusions, Intravenous; Mesna; Middle Aged; Proportional Hazards Models; Prospective Studies; Retrospective Studies; Transplantation Conditioning; Young Adult | 2015 |
19 other study(ies) available for acrolein and mesna
| Article | Year |
|---|---|
Aldophosphamide acetal diacetate and structural analogues: synthesis and cytotoxicity studies.
Topics: Animals; Antineoplastic Agents; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Survival; Drug Screening Assays, Antitumor; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Phosphoramide Mustards; Prodrugs; Structure-Activity Relationship | 1991 |
5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5-fluorouridine: a membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP).
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Membrane; CHO Cells; Cricetinae; Esterases; Fluorodeoxyuridylate; Leukemia P388; Male; Mice; Phosphoric Monoester Hydrolases; Prodrugs; Swine | 1995 |
Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.
Topics: Acrolein; Aldehydes; Animals; Cyclophosphamide; Cystitis; Female; Ifosfamide; Inactivation, Metabolic; Kidney; Male; Mesna; Rats; Urinary Bladder; Urinary Tract; Urologic Diseases | 1979 |
Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide.
Topics: Acrolein; Animals; Antibody Formation; Cell Survival; Cells, Cultured; Cyclophosphamide; DNA; Female; Liver; Mesna; Mice; Spleen | 1990 |
Identification and quantification of metabolite conjugates of activated cyclophosphamide and ifosfamide with mesna in urine by ion-pair extraction and fast atom bombardment mass spectrometry.
Topics: Acrolein; Animals; Cyclophosphamide; Ifosfamide; Kinetics; Mass Spectrometry; Mercaptoethanol; Mesna; Rats; Rats, Inbred Strains | 1985 |
Attenuation of cytogenetic damage by 2-mercaptoethanesulfonate in cultured human lymphocytes exposed to cyclophosphamide and its reactive metabolites.
Topics: Acrolein; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Cyclophosphamide; Dose-Response Relationship, Drug; Humans; Mercaptoethanol; Mesna; Mitotic Index; Mutagenicity Tests; Phosphoramide Mustards; Sister Chromatid Exchange; T-Lymphocytes | 1986 |
In vitro/in vivo effects of Mesna on the genotoxicity and toxicity of cyclophosphamide--a study aimed at clarifying the mechanism of Mesna's anticarcinogenic activity.
Topics: Acrolein; Animals; Antineoplastic Agents; Biotransformation; Cyclophosphamide; Male; Mercaptoethanol; Mesna; Mutagens; Rats; Rats, Inbred Strains | 1988 |
Effects of the cyclophosphamide metabolite acrolein in mammalian limb bud cultures.
Topics: Acrolein; Aldehydes; Animals; Biotransformation; Culture Techniques; Cyclophosphamide; Embryo, Mammalian; Extremities; Gestational Age; Limb Deformities, Congenital; Mesna; Mice; Teratogens | 1985 |
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna.
Topics: Acetaldehyde; Acrolein; Animals; CHO Cells; Cricetinae; Glutathione; Humans; Ifosfamide; Intracellular Fluid; Lymphocytes; Mesna | 1994 |
Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy.
Topics: Acrolein; Cell Death; Cyclophosphamide; Free Radical Scavengers; Half-Life; Humans; Ifosfamide; Magnetic Resonance Spectroscopy; Mesna; Perfusion; Phosphoramide Mustards; Phosphorus Isotopes; Sulfhydryl Compounds; Tumor Cells, Cultured | 1994 |
Kinetic analysis of the reactions of 4-hydroperoxycyclophosphamide and acrolein with glutathione, mesna, and WR-1065.
Topics: Acrolein; Antineoplastic Agents, Alkylating; Cell Membrane; Cyclophosphamide; Glutathione; Humans; In Vitro Techniques; Kinetics; Leukocytes, Mononuclear; Mercaptoethylamines; Mesna; Protective Agents | 2002 |
Inactivation of acrolein by sodium 2-mercaptoethanesulfonate using headspace-solid-phase microextraction gas chromatography and mass spectrometry.
Topics: Acrolein; Chelating Agents; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Mesna | 2003 |
Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells.
Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Glutathione; Ifosfamide; Kidney Tubules; Mesna; Neutral Red; Rabbits | 2003 |
Ifosfamide toxicity in cultured proximal renal tubule cells.
Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Cell Culture Techniques; Cells, Cultured; Dose-Response Relationship, Drug; Ifosfamide; Inulin; Ion Transport; Kidney Tubules, Proximal; Male; Mesna; p-Aminohippuric Acid; Protective Agents; Rabbits; Tetraethylammonium | 2007 |
A model of hemorrhagic cystitis induced with acrolein in mice.
Topics: Acrolein; Animals; Cystitis; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Hemorrhage; Male; Mesna; Mice; Protective Agents; Urinary Bladder | 2006 |
Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Acrolein; Animals; Blotting, Western; Cell Culture Techniques; Chemical and Drug Induced Liver Injury; Drug Overdose; Liver; Mesna; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
Synthesis of Reactive Polymers for Acrolein Capture Using AGET ATRP.
Topics: Acrolein; Cyclophosphamide; HEK293 Cells; Humans; Mesna; Polymerization; Protective Agents; Sulfhydryl Compounds | 2015 |
Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis.
Topics: Acrolein; Animals; Cells, Cultured; Cyclophosphamide; Cystitis; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; DNA Glycosylases; DNA Methyltransferase 3B; DNA Repair; Down-Regulation; Female; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mesna; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Smooth Muscle; Niacinamide; Reactive Oxygen Species; Urinary Bladder; Vorinostat | 2016 |
Brevetoxin induces a shift in the redox state of the proteome and unfolded protein response in human lymphoblast cells that can be alleviated with the acrolein scavenger MESNA.
Topics: Acrolein; Animals; Antioxidants; Dinoflagellida; Fishes; Humans; Mesna; Oxidation-Reduction; Proteome; Proteomics; Unfolded Protein Response | 2023 |