acrolein has been researched along with ifosfamide in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (33.33) | 18.7374 |
| 1990's | 8 (26.67) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, N; Niemeyer, U; Pohl, J; Scheffler, G; Stekar, J | 1 |
| Haeglsperger, R; Hohorst, HJ; Voelcker, G | 1 |
| Gurtoo, HL; Marinello, AJ; Paul, B; Struck, RF | 1 |
| Benckhuysen, C; Spanjersberg, EJ; van der Steen, J | 1 |
| Lelieveld, P; van Putten, LM | 1 |
| Loehrer, PJ; Munshi, NC; Williams, SD | 1 |
| Brock, N; Dietrich, I; Hilgard, P; Manz, I; Niemeyer, U; Pohl, J; Przybylski, M | 1 |
| Bryant, BM; Ford, HT; Jarman, M; Smith, IE | 1 |
| Borch, RF; Low, JE; Sladek, NE | 1 |
| Saiers, JH; Slavik, M | 1 |
| Heydrich, D; Hohorst, HJ; Jork, T; Voelcker, G; Wagner, T | 1 |
| Ansorge, S; Brandis, M; Mohrmann, M; Schmich, U; Schönfeld, B | 1 |
| Allenbacher, A; Botzler, C; Issels, R; Meier, T; Mueller, E; Multhoff, G; Wiesnet, M | 1 |
| Morris, ME; Springate, JE; Zamlauski-Tucker, MJ | 1 |
| Butler, AM; Murray, M; Stupans, I | 1 |
| Boal, JH; Engel, J; Ho, CK; Ludeman, SM; Niemeyer, U | 1 |
| Chang, TK; Waxman, DJ | 1 |
| Blaschke, G; Boos, J; Hohenlöchter, B; Jürgens, H; Rossi, R; Silies, H | 1 |
| Baumann, F; Geissler, F; Hanschmann, H; Hauss, J; Pahlig, H; Preiss, R; Ratzewiss, B; Schmidt, R | 1 |
| Gamcsik, MP; Ludeman, SM | 1 |
| Springate, JE; Taub, M; Zaki, EL | 1 |
| Namera, A; Sakura, N; Takamoto, S; Yashiki, M | 1 |
| Batista, CK; Brito, GA; Cunha, FQ; Leitão, BT; Mota, JM; Ribeiro, RA; Souza, MH; Souza, ML | 1 |
| Springate, J; Taub, M | 1 |
| Korkmaz, A; Oter, S; Topal, T | 1 |
| Dolan, ME; Hansen, RJ; Ludeman, SM; Paikoff, SJ; Pegg, AE | 1 |
| Leclerc, E; Legallais, C; Monge, M; Ould-Dris, A; Paullier, P; Ramello, C | 1 |
| Lau, V; MacAllister, SL; Martin-Brisac, N; O'Brien, PJ; Yang, K | 1 |
| Couch, JR; de Perio, MA; Page, EH | 1 |
| Jiang, L; Li, Z; Qin, J; Shi, Y; Su, W; Tao, T; Xu, C; Zhu, Y | 1 |
3 review(s) available for acrolein and ifosfamide
| Article | Year |
|---|---|
Uroprotection in patients receiving cyclophosphamide and ifosfamide.
Topics: Acrolein; Cyclophosphamide; Humans; Ifosfamide; Sulfhydryl Compounds; Urinary Tract; Urologic Diseases | 1991 |
Mechanisms of resistance against cyclophosphamide and ifosfamide: can they be overcome without sacrificing selectivity?
Topics: Acrolein; Aldehyde Dehydrogenase; Antineoplastic Agents, Alkylating; Cyclophosphamide; DNA Repair; Drug Resistance, Neoplasm; Humans; Ifosfamide; Models, Chemical; O(6)-Methylguanine-DNA Methyltransferase; Phosphoramide Mustards; Stereoisomerism | 2002 |
Pathophysiological aspects of cyclophosphamide and ifosfamide induced hemorrhagic cystitis; implication of reactive oxygen and nitrogen species as well as PARP activation.
Topics: Acrolein; Antineoplastic Agents; Cell Death; Cyclophosphamide; Cystitis; Cytokines; DNA Damage; Enzyme Activation; Hemorrhage; Humans; Ifosfamide; Lipid Peroxidation; Mesna; Nitrogen; Oxygen; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Transcription Factors | 2007 |
1 trial(s) available for acrolein and ifosfamide
| Article | Year |
|---|---|
Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma.
Topics: Acrolein; Carcinoma, Bronchogenic; Clinical Trials as Topic; Cyclophosphamide; Female; Hematuria; Humans; Ifosfamide; Kinetics; Lung Neoplasms; Male; Mercaptoethanol; Mesna; Phosphoramide Mustards; Urinary Bladder | 1980 |
26 other study(ies) available for acrolein and ifosfamide
| Article | Year |
|---|---|
Acrolein, the causative factor of urotoxic side-effects of cyclophosphamide, ifosfamide, trofosfamide and sufosfamide.
Topics: Acrolein; Aldehydes; Animals; Cyclophosphamide; Cystitis; Female; Ifosfamide; Inactivation, Metabolic; Kidney; Male; Mesna; Rats; Urinary Bladder; Urinary Tract; Urologic Diseases | 1979 |
[Fluorometric determination of "activated" cyclophosphamide and ifosfamide in blood (author's transl)].
Topics: Acrolein; Aminophenols; Animals; Cyclophosphamide; Fluorometry; Ifosfamide; Mice | 1979 |
Denaturation of cytochrome P-450 by cyclophosphamide metabolites.
Topics: Acrolein; Aldehydes; Animals; Biotransformation; Cyclophosphamide; Cytochrome P-450 Enzyme System; Ifosfamide; Microsomes, Liver; Phosphoramide Mustards; Protein Denaturation; Rats | 1978 |
Two stable Fenton oxidation products of cyclophosphamide (NSC-26271) as precursors of 4-hydroxycyclophosphamide (NSC-196562) under physiologic conditions.
Topics: Acrolein; Alkylation; Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Cyclophosphamide; Free Radicals; Ifosfamide; Lethal Dose 50; Models, Chemical; Oxidation-Reduction; Peroxides; Sarcoma, Yoshida; Time Factors | 1976 |
Biologic activity of two derivatives and six possible metabolites of cyclophosphamide (NSC-26271).
Topics: Acrolein; Animals; Antineoplastic Agents; Biotransformation; Cells, Cultured; Cyclophosphamide; Dose-Response Relationship, Drug; Female; Hematopoietic Stem Cells; Hydroxylation; Ifosfamide; Leukemia L1210; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Neoplasms, Experimental; Nitrogen Mustard Compounds; Osteosarcoma; Oxazines | 1976 |
Identification and quantification of metabolite conjugates of activated cyclophosphamide and ifosfamide with mesna in urine by ion-pair extraction and fast atom bombardment mass spectrometry.
Topics: Acrolein; Animals; Cyclophosphamide; Ifosfamide; Kinetics; Mass Spectrometry; Mercaptoethanol; Mesna; Rats; Rats, Inbred Strains | 1985 |
Further studies on the conversion of 4-hydroxyoxazaphosphorines to reactive mustards and acrolein in inorganic buffers.
Topics: Acrolein; Aldehydes; Buffers; Chemical Phenomena; Chemistry; Cyclophosphamide; Hydrogen-Ion Concentration; Ifosfamide; Kinetics; Nitrogen Mustard Compounds; Osmolar Concentration; Structure-Activity Relationship; Temperature | 1983 |
Phase I clinical study of acetylcysteine's preventing ifosfamide-induced hematuria.
Topics: Acetylcysteine; Acrolein; Adenocarcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Cystitis; Dose-Response Relationship, Drug; Drug Evaluation; Drug Therapy, Combination; Hematuria; Humans; Ifosfamide; Lung Neoplasms | 1983 |
Comparative study on human pharmacokinetics of activated ifosfamide and cyclophosphamide by a modified fluorometric test.
Topics: Acrolein; Biotransformation; Cyclophosphamide; Female; Humans; Ifosfamide; Kinetics; Male; Middle Aged; Spectrometry, Fluorescence | 1981 |
Toxicity of ifosfamide, cyclophosphamide and their metabolites in renal tubular cells in culture.
Topics: Acetaldehyde; Acrolein; Animals; Cell Line; Cells, Cultured; Cyclophosphamide; DNA; DNA Replication; Epithelial Cells; Epithelium; Ifosfamide; Kidney Tubules, Proximal; RNA; Swine; Thymidine; Uridine | 1994 |
Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna.
Topics: Acetaldehyde; Acrolein; Animals; CHO Cells; Cricetinae; Glutathione; Humans; Ifosfamide; Intracellular Fluid; Lymphocytes; Mesna | 1994 |
Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney.
Topics: Absorption; Acetaldehyde; Acrolein; Animals; Chemotherapy, Cancer, Regional Perfusion; Disease Models, Animal; Fanconi Syndrome; Glucose; Ifosfamide; Kidney; Kidney Tubules, Proximal; Male; Organ Size; Phosphates; Prodrugs; Rats; Rats, Inbred Lew; Sodium; Sulfates | 1994 |
Competitive inhibition of human liver microsomal cytochrome P450 3A-dependent steroid 6 beta-hydroxylation activity by cyclophosphamide and ifosfamide in vitro.
Topics: Acrolein; Animals; Binding, Competitive; Cyclophosphamide; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Ifosfamide; Microsomes, Liver; Mixed Function Oxygenases; NADP; Rats; Rats, Wistar; Steroid Hydroxylases; Testosterone | 1994 |
Direct detection of the intracellular formation of carboxyphosphamides using nuclear magnetic resonance spectroscopy.
Topics: Acrolein; Cell Death; Cyclophosphamide; Free Radical Scavengers; Half-Life; Humans; Ifosfamide; Magnetic Resonance Spectroscopy; Mesna; Perfusion; Phosphoramide Mustards; Phosphorus Isotopes; Sulfhydryl Compounds; Tumor Cells, Cultured | 1994 |
Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Acrolein; Animals; Aryl Hydrocarbon Hydroxylases; Cyclophosphamide; Cytochrome P-450 Enzyme System; Drug Combinations; Ifosfamide; Male; Phosphoramide Mustards; Rats; Rats, Inbred F344; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone | 1993 |
Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion.
Topics: Acetaldehyde; Acrolein; Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Female; Humans; Ifosfamide; Infusions, Intravenous; Kidney; Male; Neoplasms; Phosphoramide Mustards | 1998 |
Measurement of 4-hydroxylation of ifosfamide in human liver microsomes using the estimation of free and protein-bound acrolein and codetermination of keto- and carboxyifosfamide.
Topics: Acrolein; Biomarkers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Humans; Hydroxylation; Ifosfamide; Isoenzymes; Microsomes, Liver; Protein Binding | 2002 |
Comparative toxicity of ifosfamide metabolites and protective effect of mesna and amifostine in cultured renal tubule cells.
Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Antineoplastic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Glutathione; Ifosfamide; Kidney Tubules; Mesna; Neutral Red; Rabbits | 2003 |
Monitoring of urinary acrolein concentration in patients receiving cyclophosphamide and ifosphamide.
Topics: Acrolein; Adolescent; Adult; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Cyclophosphamide; Female; Gas Chromatography-Mass Spectrometry; Humans; Ifosfamide; Male | 2004 |
Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis.
Topics: Acrolein; Amifostine; Animals; Antidotes; Antineoplastic Agents, Alkylating; Cystitis; Dose-Response Relationship, Drug; Edema; Glutathione; Hemorrhage; Ifosfamide; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Radiation-Protective Agents; Urinary Bladder | 2007 |
Ifosfamide toxicity in cultured proximal renal tubule cells.
Topics: Acetaldehyde; Acrolein; Amifostine; Animals; Cell Culture Techniques; Cells, Cultured; Dose-Response Relationship, Drug; Ifosfamide; Inulin; Ion Transport; Kidney Tubules, Proximal; Male; Mesna; p-Aminohippuric Acid; Protective Agents; Rabbits; Tetraethylammonium | 2007 |
Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
Topics: Acetaldehyde; Acrolein; Alkylating Agents; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclophosphamide; DNA Repair; Drug Resistance, Neoplasm; Ifosfamide; Mice; Mice, Knockout; Mutation; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Recombinant Proteins; Transfection; Transplantation, Heterologous | 2007 |
Investigation into modification of mass transfer kinetics by acrolein in a renal biochip.
Topics: Acrolein; Albumins; Animals; Bioartificial Organs; Biomarkers; Caffeine; Cell Line; Cyclophosphamide; Dimethylpolysiloxanes; Dogs; Ifosfamide; Kidney; Kinetics; Microfluidic Analytical Techniques; Models, Biological; Protein Array Analysis; Renal Dialysis; Vitamin B 12 | 2011 |
Acrolein and chloroacetaldehyde: an examination of the cell and cell-free biomarkers of toxicity.
Topics: Acetaldehyde; Acrolein; Aldehyde Dehydrogenase; Animals; Biomarkers; Cell-Free System; Cyclophosphamide; Hepatocytes; Hydrogen Peroxide; Ifosfamide; Inactivation, Metabolic; Male; Microsomes, Liver; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Serum Albumin, Bovine | 2013 |
Evaluation of a multiple sclerosis cluster among nurses in an inpatient oncology ward.
Topics: Acrolein; Adult; Air Pollutants, Occupational; Air Pollution, Indoor; Antineoplastic Agents, Alkylating; Carbon Monoxide; Cyclophosphamide; Female; Humans; Ifosfamide; Multiple Sclerosis; Nursing Staff, Hospital; Occupational Exposure; Oncology Service, Hospital; Vehicle Emissions | 2015 |
Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice.
Topics: Acrolein; Animals; Antineoplastic Agents, Alkylating; Calcium Channel Blockers; Cell Survival; Coculture Techniques; Epithelial Cells; Hep G2 Cells; Humans; Ifosfamide; Kidney; Lab-On-A-Chip Devices; Liver; Phosphoramide Mustards; Rats; Verapamil | 2018 |