acrolein has been researched along with deoxyguanosine in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.88) | 18.7374 |
| 1990's | 12 (17.65) | 18.2507 |
| 2000's | 35 (51.47) | 29.6817 |
| 2010's | 16 (23.53) | 24.3611 |
| 2020's | 1 (1.47) | 2.80 |
| Authors | Studies |
|---|---|
| Gurtoo, HL; Lee, L; Maccubbin, AE; Struck, RF | 1 |
| Akerkar, SA; Chung, FL; Foiles, PG; Miglietta, LM | 1 |
| Bastian, H; Deininger, C; Eder, E; Hoffman, C; Scheckenbach, S | 1 |
| Meerman, JH; Meier, GP; Nelson, SD; Pearson, PG; Smith, TR | 1 |
| Akerkar, SA; Chung, FL; Foiles, PG | 1 |
| Bastian, H; Deininger, C; Eder, E; Hoffman, C; Wiedenmann, M | 1 |
| Chung, FL; Hecht, SS; Palladino, G | 1 |
| Eder, E; Hoffman, C | 1 |
| Meerman, JH; Nelson, SD; van Beerendonk, GJ | 1 |
| Chung, FL; Nath, RG | 1 |
| Chen, HJ; Chung, FL; Nath, RG; Nishikawa, A; Young-Sciame, R | 1 |
| Chung, FL; Nath, RG; Ocando, JE | 1 |
| Hecht, SS; Liu, Z; Young-Sciame, R | 1 |
| Eliezer, N; Mahle, NH; Marnett, LJ; Miller, R; Nokubo, M; O'Hara, SM; Rouzer, CA; Sevilla, CL; Uzieblo, A | 1 |
| Johnson, F; Khullar, S; Varaprasad, CV | 1 |
| Chung, FL; Nath, RG; Ocando, JE; Zhang, L | 1 |
| Harris, CM; Harris, TM; Nechev, LV | 1 |
| Asayama, K; Hirano, A; Horiuchi, S; Jono, T; Kato, S; Kobayashi, M; Miyata, S; Nagai, R; Sasaki, S; Shibata, N | 1 |
| de los Santos, C; Johnson, F; Zaliznyak, T | 1 |
| Grollman, A; Hossain, M; Johnson, F; Khullar, S; Miller, H; Moriya, M; Yang, IY | 1 |
| Chen, L; Chung, FL; Henk, W; Nath, R; Pan, J; Penn, A; Widmer, K | 1 |
| Harris, CM; Harris, TM; Kozekov, ID; Lloyd, RS; Nechev, LV; Sanchez, A | 1 |
| Grollman, AP; Johnson, F; Moriya, M; Yang, IY | 1 |
| Huang, Y; Johnson, F | 1 |
| Harris, CM; Harris, TM; Kanuri, M; Lloyd, RS; Minko, IG; Nechev, LV | 1 |
| Chung, FL; Pan, J | 1 |
| Kanuri, M; Lloyd, RS; Minko, IG; Prakash, L; Prakash, S; Washington, MT | 1 |
| Chan, G; Huang, Y; Johnson, F; Miller, H; Moriya, M; Torres, MC; Yang, IY | 1 |
| Kurtz, AJ; Lloyd, RS | 1 |
| Frank, EG; Hanaoka, F; Miller, H; Moriya, M; Ohmori, H; Wang, Z; Yang, IY | 1 |
| Hiraoka, M; Mayumi, M; Nishima, S; Ohshima, Y; Ohta, N; Sato, S; Shibata, R; Todoroki, Y; Tsukahara, H; Yoshida, A | 1 |
| Cecilia Torres, M; Huang, Y; Iden, CR; Johnson, F | 1 |
| Beppu, M; Hata, I; Hiraoka, M; Kaji, M; Kawakami, H; Mayumi, M; Momoi, T; Sekine, K; Todoroki, Y; Tsukahara, H; Uchiyama, M; Yorifuji, T; Yoshihara, K | 1 |
| Skrzydlewska, E; Łuczaj, W | 1 |
| Kanuri, M; Kurtz, AJ; Lloyd, RS; Minko, IG; Moriya, M; Sanchez, AM | 1 |
| Hiraoka, M; Jiang, MZ; Maeda, M; Mayumi, M; Ohta, N; Sato, S; Tamura, S; Tsukahara, H | 1 |
| D'Isa, G; Galeone, A; Mayol, L; Oliviero, G; Piccialli, G; Varra, M | 1 |
| Liu, X; Lovell, MA; Lynn, BC | 1 |
| Johnson, RE; Lloyd, RS; Minko, IG; Prakash, L; Prakash, S; Wolfle, WT | 1 |
| Cho, YJ; Harris, TM; Huang, H; Jacob, J; Kim, HY; Kozekov, ID; Kozekova, A; Lloyd, RS; Minko, IG; Nechev, LV; Rizzo, CJ; Slutsky, A; Stone, MP; Tamura, P; Voehler, M; Wang, H | 1 |
| Kawakami, H; Maeda, M; Mayumi, M; Sekine, K; Tamura, S; Tsukahara, H; Ueno, M | 1 |
| Fujino, T; Fukuzawa, J; Hasebe, N; Hirayama, T; Kikuchi, K; Nakagawa, N; Sumitomo, K | 1 |
| Hecht, SS; Villalta, PW; Wang, M; Zhang, S | 1 |
| Fukagawa, M; Hamada, Y | 1 |
| Harris, TM; Kozekov, ID; Kozekova, A; Lloyd, RS; Minko, IG; Rizzo, CJ | 1 |
| Hayashi, M; Kurata, K; Miyata, R; Tanuma, N; Uchiyama, A | 1 |
| Cao, J; Geng, C; Jiang, L; Li, L; Zhong, L | 1 |
| Hu, Y; Tang, MS; Wang, HT; Zhang, S | 1 |
| Chung, FL; Emami, A; Goldman, R; Keffer, J; Lan, R; Ma, X; Pan, J | 1 |
| Harris, TM; Kozekov, ID; Lloyd, RS; Minko, IG; Rizzo, CJ; Stone, MP | 1 |
| Chen, HJ; Lin, WP | 1 |
| Bonala, R; de los Santos, C; El-khateeb, M; Johnson, F; Lukin, M; Zaliznyak, T | 1 |
| Liu, XY; Xie, JP; Zhu, MX | 1 |
| Chung, FL; Emami, A; Nath, RG; Wu, MY | 1 |
| Huang, H; Kozekov, ID; Kozekova, A; Lloyd, RS; McCullough, AK; Rizzo, CJ; Stone, MP | 1 |
| Alas, GR; Harris, CM; Harris, TM; Kozekov, ID; Rizzo, CJ; Turesky, RJ | 1 |
| Balbo, S; Hecht, SS; Wang, M; Zhang, S | 1 |
| Huang, H; Kozekova, A; Lloyd, RS; McCullough, AK; Rizzo, CJ; Stone, MP; Voehler, MW; Wang, H | 1 |
| Chen, HJ | 1 |
| Basudan, A; Chung, FL; Dyba, M; Nath, RG; Wu, MY | 1 |
| Dorjsuren, D; Egli, M; Eoff, RL; Jadhav, A; Lloyd, RS; Maloney, DJ; Simeonov, A; Yamanaka, K | 1 |
| Carollo, V; Corino, C; Deponti, D; Di Giancamillo, A; Domeneghini, C; Rossi, R; Vitari, F | 1 |
| Copeland, WC; Kasiviswanathan, R; Lloyd, RS; Minko, IG | 1 |
| Chen, X; Huang, J; Li, J; Li, M; Li, X; Liang, X; Luo, Y; Ma, W; Tang, S; Xiao, W | 1 |
| Delaney, JC; Essigmann, JM; Fedeles, BI; Kozekov, ID; Kozekova, A; Li, D; Marnett, LJ; Rizzo, CJ; Singh, V | 1 |
| Atlı Şekeroğlu, Z; Aydın, B; Şekeroğlu, V | 1 |
| Hackfeld, LC; Hodge, RP; Park, J; Prakash, L; Prakash, S; Roy Choudhury, J; Yoon, JH | 1 |
| Guo, Y; Wu, C; Zhang, F | 1 |
5 review(s) available for acrolein and deoxyguanosine
| Article | Year |
|---|---|
Formation of thymidine, cyclic deoxyguanosine and cyclic deoxycytidine adducts of the mutagen 2-bromoacrolein and their role in mutagenicity and clastogenicity.
Topics: Acrolein; Animals; Deoxycytidine; Deoxyguanosine; DNA Adducts; DNA, Single-Stranded; Mutagens; Rats; Thymidine | 1994 |
Role of 1,N2-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans.
Topics: Acrolein; Aldehydes; Animals; Arachidonic Acid; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Docosahexaenoic Acids; Fatty Acids; Glutathione; Humans; Linoleic Acid; Lipid Peroxidation; Mice; Models, Chemical; Rats | 1999 |
Chemistry and biology of DNA containing 1,N(2)-deoxyguanosine adducts of the alpha,beta-unsaturated aldehydes acrolein, crotonaldehyde, and 4-hydroxynonenal.
Topics: Acrolein; Aldehydes; Base Sequence; Deoxyguanosine; DNA Adducts; DNA Repair; Mutagenesis; Oligodeoxyribonucleotides | 2009 |
Mutagenicity of acrolein and acrolein-induced DNA adducts.
Topics: Acrolein; Animals; Cross-Linking Reagents; Deoxyguanosine; DNA; DNA Adducts; Humans; Lung; Mutagenicity Tests; Mutagens; Oligonucleotides | 2010 |
Analysis of DNA adducts in human samples: acrolein-derived exocyclic DNA adducts as an example.
Topics: Acrolein; Deoxyguanosine; DNA Adducts; Humans; Mass Spectrometry; Phosphorus Radioisotopes; Sensitivity and Specificity; Smoking | 2011 |
63 other study(ies) available for acrolein and deoxyguanosine
| Article | Year |
|---|---|
32P-postlabeling of acrolein-deoxyguanosine adducts in DNA after nuclease P1 digestion.
Topics: Acid Phosphatase; Acrolein; Adenosine Triphosphate; Animals; Cattle; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cyclization; Deoxyguanosine; Dinucleoside Phosphates; DNA; Isotope Labeling; Phosphates; Phosphorus Radioisotopes; Single-Strand Specific DNA and RNA Endonucleases; Spectrophotometry, Ultraviolet | 1992 |
Formation of cyclic deoxyguanosine adducts in Chinese hamster ovary cells by acrolein and crotonaldehyde.
Topics: Acrolein; Aldehydes; Animals; Cells, Cultured; Cricetinae; Deoxyguanosine; DNA; Mutagenicity Tests | 1990 |
Molecular mechanisms of DNA damage initiated by alpha, beta-unsaturated carbonyl compounds as criteria for genotoxicity and mutagenicity.
Topics: Acrolein; Deoxyguanosine; DNA Damage; Guanine; Ketones; Mutagenicity Tests; Mutagens; Structure-Activity Relationship | 1990 |
Formation of cyclic 1,N2-propanodeoxyguanosine and thymidine adducts in the reaction of the mutagen 2-bromoacrolein with calf thymus DNA.
Topics: Acrolein; Aldehydes; Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA, Single-Stranded; Indicators and Reagents; Liver; Liver Regeneration; Magnetic Resonance Spectroscopy; Molecular Structure; Mutagens; Rats; RNA; Thymidine | 1989 |
Application of an immunoassay for cyclic acrolein deoxyguanosine adducts to assess their formation in DNA of Salmonella typhimurium under conditions of mutation induction by acrolein.
Topics: Acrolein; Aldehydes; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Damage; DNA, Bacterial; Immunoassay; Mutation; Salmonella typhimurium | 1989 |
Detection of acrolein congener-DNA adducts isolated from cellular systems.
Topics: Acrolein; Aldehydes; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; Deoxyguanosine; DNA Damage; DNA, Bacterial; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mutagenicity Tests; Reference Standards; Salmonella typhimurium; Spectrometry, Fluorescence; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Stereoisomerism | 1989 |
Formation of cyclic nucleic acid adducts from some simple alpha, beta-unsaturated carbonyl compounds and cyclic nitrosamines.
Topics: Acetaldehyde; Acrolein; Animals; Biotransformation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Deoxyguanosine; Esterases; Magnetic Resonance Spectroscopy; Models, Chemical; N-Nitrosopyrrolidine; Nitrosamines; Spectrum Analysis; Swine | 1986 |
1,N2-cyclic deoxyguanosine adducts and guanine adducts of 2-haloacroleins. Isolation, characterization, isomerization and stability.
Topics: Acrolein; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Guanine; Magnetic Resonance Spectroscopy; Mutagens; Nucleic Acid Conformation; Nucleotides; Spectrophotometry, Ultraviolet; Stereoisomerism; Terminology as Topic | 1994 |
Detection of exocyclic 1,N2-propanodeoxyguanosine adducts as common DNA lesions in rodents and humans.
Topics: Acrolein; Adult; Aged; Aged, 80 and over; Aldehydes; Animals; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Damage; Female; Humans; Liver; Male; Mice; Middle Aged; Rats; Reference Standards; Stereoisomerism | 1994 |
A 32P-postlabeling method for simultaneous detection and quantification of exocyclic etheno and propano adducts in DNA.
Topics: Acrolein; Aldehydes; Deoxyguanosine; DNA; Isotope Labeling; Phosphorus Radioisotopes; Stereoisomerism | 1994 |
Detection of 1, N2-propanodeoxyguanosine adducts as potential endogenous DNA lesions in rodent and human tissues.
Topics: Acrolein; Adult; Aldehydes; Animals; Carcinogens; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; Female; Humans; Male; Mice; Mice, Inbred A; Middle Aged; Phosphorus Radioisotopes; Rats; Rats, Inbred F344 | 1996 |
Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.
Topics: Acrolein; Alkaline Phosphatase; Animals; Carcinogens; Cattle; Chromatography, High Pressure Liquid; Deoxyguanosine; Deoxyribonuclease I; DNA Adducts; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Hydroxylation; Magnetic Resonance Spectroscopy; Mutagens; Nitroso Compounds; Phosphodiesterase I; Phosphoric Diester Hydrolases; Piperidines; Spectrophotometry, Ultraviolet; Thymus Gland; Tritium | 1996 |
Development of monoclonal antibodies to the malondialdehyde-deoxyguanosine adduct, pyrimidopurinone.
Topics: Acrolein; Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Binding, Competitive; Deoxyguanosine; DNA; DNA Adducts; DNA, Bacterial; Hybridomas; Hydrolysis; Malondialdehyde; Mice; Mice, Inbred BALB C; Salmonella typhimurium | 1997 |
Postsynthetic generation of a major acrolein adduct of 2'-deoxyguanosine in oligomeric DNA.
Topics: Acrolein; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Environmental Pollutants | 1999 |
Synthesis of nucleosides and oligonucleotides containing adducts of acrolein and vinyl chloride.
Topics: Acrolein; Chromatography, High Pressure Liquid; Deoxyadenosines; Deoxyguanosine; DNA; DNA Adducts; Ethylene Oxide; Mutagens; Nucleosides; Oligonucleotides; Vinyl Chloride | 2000 |
Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Adult; Aged; Aldehydes; Amyotrophic Lateral Sclerosis; Arginine; Deoxyguanosine; Glycosylation; Humans; Imidazoles; Lipid Peroxidation; Lysine; Male; Middle Aged; Motor Neurons; Oxidative Stress; Spinal Cord; Superoxide Dismutase | 2000 |
NMR characterization of a DNA duplex containing the major acrolein-derived deoxyguanosine adduct gamma -OH-1,-N2-propano-2'-deoxyguanosine.
Topics: Acrolein; Deoxyguanosine; DNA; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protons | 2001 |
Responses to the major acrolein-derived deoxyguanosine adduct in Escherichia coli.
Topics: Acrolein; Base Sequence; Catalysis; Deoxyguanosine; DNA Polymerase I; DNA Polymerase III; DNA Primers; DNA Repair; DNA Replication; DNA, Bacterial; Escherichia coli; Molecular Sequence Data; Recombination, Genetic | 2001 |
1,N(2)-propanodeoxyguanosine adduct formation in aortic DNA following inhalation of acrolein.
Topics: Acrolein; Air Pollutants; Animals; Aorta; Chickens; Chromatography, High Pressure Liquid; Coronary Artery Disease; Deoxyguanosine; DNA Adducts; Mutagens; Tobacco Smoke Pollution | 2001 |
Interchain cross-linking of DNA mediated by the principal adduct of acrolein.
Topics: Acrolein; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Deoxyguanosine; DNA Adducts; Humans; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2001 |
Genotoxic mechanism for the major acrolein-derived deoxyguanosine adduct in human cells.
Topics: Acrolein; Base Sequence; Deoxyguanosine; DNA Adducts; DNA Damage; HeLa Cells; Humans; Molecular Sequence Data; Mutagens | 2002 |
Regioisomeric synthesis and characteristics of the alpha-hydroxy-1,N(2)-propanodeoxyguanosine.
Topics: Acrolein; Chromatography, High Pressure Liquid; Deoxyguanosine | 2002 |
Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells.
Topics: Acrolein; Animals; Base Sequence; COS Cells; Deoxyguanosine; DNA; DNA Damage; DNA Replication; Molecular Sequence Data; Nucleic Acid Conformation | 2002 |
Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions.
Topics: Acrolein; Aldehydes; alpha-Linolenic Acid; Arachidonic Acid; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; Deoxyguanosine; DNA Adducts; DNA Damage; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Linoleic Acid; Oxidation-Reduction; Stearic Acids | 2002 |
Translesion synthesis past acrolein-derived DNA adduct, gamma -hydroxypropanodeoxyguanosine, by yeast and human DNA polymerase eta.
Topics: Acrolein; Deoxyguanosine; DNA Adducts; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; Humans; Saccharomyces cerevisiae Proteins | 2003 |
Mutagenesis by acrolein-derived propanodeoxyguanosine adducts in human cells.
Topics: Acrolein; Base Pair Mismatch; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Primers; DNA Repair; DNA Replication; Escherichia coli; Genetic Vectors; HeLa Cells; Humans; Mutagenesis; Xeroderma Pigmentosum | 2002 |
1,N2-deoxyguanosine adducts of acrolein, crotonaldehyde, and trans-4-hydroxynonenal cross-link to peptides via Schiff base linkage.
Topics: Acrolein; Aldehydes; Amino Acid Sequence; Cross-Linking Reagents; Deoxyguanosine; DNA Adducts; Kinetics; Models, Molecular; Molecular Structure; Oligopeptides; Schiff Bases | 2003 |
Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells.
Topics: Acrolein; Cell Line; Cell Line, Transformed; Deoxyguanosine; DNA; DNA Adducts; DNA Primers; DNA-Directed DNA Polymerase; Humans; Models, Chemical; Oligonucleotide Probes; Oligonucleotides; Plasmids; Proliferating Cell Nuclear Antigen | 2003 |
Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Acute Disease; Antioxidants; Bilirubin; Biomarkers; Child; Child, Preschool; Deoxyguanosine; Dermatitis, Atopic; Female; Humans; Infant; Lysine; Male; Nitrates; Nitrites; Oxidative Stress | 2003 |
Synthesis of the minor acrolein adducts of 2(')-deoxyguanosine and their generation in oligomeric DNA.
Topics: Acrolein; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA Adducts; Oligonucleotides | 2003 |
Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Adolescent; Adult; Arginine; Child; Child, Preschool; Creatinine; Deoxyguanosine; Diabetes Mellitus, Type 1; Female; Glycation End Products, Advanced; Humans; Lysine; Male; Norleucine; Oxidative Stress; Pyrroles; Regression Analysis | 2003 |
DNA damage caused by lipid peroxidation products.
Topics: Acrolein; Aldehydes; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; DNA Adducts; DNA Damage; Lipid Peroxidation | 2003 |
Comparative evaluation of the bioreactivity and mutagenic spectra of acrolein-derived alpha-HOPdG and gamma-HOPdG regioisomeric deoxyguanosine adducts.
Topics: Acrolein; Animals; Chlorocebus aethiops; COS Cells; Cross-Linking Reagents; Deoxyguanosine; DNA; DNA Adducts; Mutagenicity Tests; Oligonucleotides; Stereoisomerism | 2003 |
Oxidative stress in neonates: evaluation using specific biomarkers.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Biomarkers; Deoxyguanosine; DNA Damage; Female; Humans; Infant, Newborn; Lipid Peroxidation; Lysine; Male; Nitric Oxide; Oxidative Stress | 2004 |
Effect of gamma-hydroxypropano deoxyguanosine, the major acrolein-derived adduct, on monomolecular quadruplex structure of telomeric repeat d(TTAGGG)(4).
Topics: Acrolein; Buffers; Circular Dichroism; Deoxyguanosine; DNA Adducts; Electrophoresis, Polyacrylamide Gel; Humans; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Potassium; Repetitive Sequences, Nucleic Acid; Sodium; Temperature | 2004 |
Development of a method for quantification of acrolein-deoxyguanosine adducts in DNA using isotope dilution-capillary LC/MS/MS and its application to human brain tissue.
Topics: Acrolein; Brain; Capillaries; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deoxyguanosine; DNA Adducts; Humans; Indicator Dilution Techniques; Ions; Isotopes; Molecular Structure; Sensitivity and Specificity; Tandem Mass Spectrometry | 2005 |
Human DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA.
Topics: Acrolein; Cytosine; Deoxyguanosine; DNA; DNA Adducts; DNA Polymerase iota; DNA Primers; DNA Replication; DNA-Directed DNA Polymerase; Escherichia coli; Guanine; Humans; Kinetics; Models, Chemical; Nucleic Acid Conformation; Nucleotides; Polyamines; Purines | 2005 |
Spectroscopic characterization of interstrand carbinolamine cross-links formed in the 5'-CpG-3' sequence by the acrolein-derived gamma-OH-1,N2-propano-2'-deoxyguanosine DNA adduct.
Topics: Acrolein; Carbon Isotopes; CpG Islands; Cross-Linking Reagents; Deoxyguanosine; DNA; DNA Adducts; Hydrogen Bonding; Isotope Labeling; Models, Molecular; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Oligonucleotides; Oligopeptides; Stereoisomerism; Substrate Specificity | 2005 |
Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Adolescent; Adult; Arginine; Biomarkers; Child; Child, Preschool; Deoxyguanosine; Female; Glycation End Products, Advanced; Humans; Infant; Lysine; Male; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Reactive Oxygen Species | 2006 |
An oral adsorbent, AST-120, suppresses oxidative stress in uremic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Adsorption; Animals; Carbon; Deoxyguanosine; Immunohistochemistry; Male; Oxidative Stress; Oxides; Rats; Rats, Sprague-Dawley; Uremia | 2006 |
Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Topics: Acrolein; Calibration; Chromatography, Liquid; Deoxyguanosine; Humans; Lung; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
A possible role of thioredoxin interacting protein in the pathogenesis of streptozotocin-induced diabetic nephropathy.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Albuminuria; Animals; Biomarkers; Carrier Proteins; Collagen Type IV; Deoxyguanosine; Diabetic Nephropathies; Hypertrophy; Kidney; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; RNA, Messenger; Streptozocin; Thioredoxins; Transforming Growth Factor beta | 2007 |
Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts.
Topics: Acrolein; Animals; Chlorocebus aethiops; COS Cells; Cross-Linking Reagents; Deoxyadenosines; Deoxyguanosine; DNA Adducts; DNA Damage; Mutagenesis; Peptides; Transfection | 2008 |
Oxidative stress as a biomarker of respiratory disturbance in patients with severe motor and intellectual disabilities.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Adolescent; Adult; Biomarkers; Child; Deoxyguanosine; Female; Hexanols; Humans; Lipid Peroxidation; Male; Mental Disorders; Middle Aged; Motor Neuron Disease; Oxidative Stress; Respiration Disorders; Statistics, Nonparametric | 2008 |
The role of oxidative stress in acrolein-induced DNA damage in HepG2 cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Cell Line, Tumor; Cell Survival; Comet Assay; Cross-Linking Reagents; Deoxyguanosine; DNA Damage; Electrophoresis; Endopeptidase K; Fluoresceins; Glutathione; Humans; o-Phthalaldehyde; Oxidative Stress; Reactive Oxygen Species | 2008 |
Mutagenicity and sequence specificity of acrolein-DNA adducts.
Topics: Acrolein; Animals; Base Sequence; Deoxyguanine Nucleotides; Deoxyguanosine; DNA Adducts; DNA Repair; Genes, p53; Humans; Lung Neoplasms; Mice; Mutagenesis; Smoking | 2009 |
Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Anticarcinogenic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Collagen Type XI; Colonic Neoplasms; Deoxyguanosine; DNA Adducts; DNA Damage; Docosahexaenoic Acids; Fatty Acids, Unsaturated; G1 Phase; HT29 Cells; Humans; Lipid Peroxidation | 2009 |
Simultaneous quantification of 1,N2-propano-2'-deoxyguanosine adducts derived from acrolein and crotonaldehyde in human placenta and leukocytes by isotope dilution nanoflow LC nanospray ionization tandem mass spectrometry.
Topics: Acrolein; Aldehydes; Biomarkers; Chromatography, Liquid; Clinical Chemistry Tests; Deoxyguanosine; DNA; DNA Damage; Feasibility Studies; Female; Humans; Isotopes; Leukocytes; Nanotechnology; Placenta; Pregnancy; Reproducibility of Results; Stereoisomerism; Tandem Mass Spectrometry; Time Factors | 2009 |
NMR structure of duplex DNA containing the alpha-OH-PdG.dA base pair: a mutagenic intermediate of acrolein.
Topics: Acrolein; Deoxyadenosines; Deoxyguanosine; DNA; DNA Damage; Models, Molecular; Molecular Dynamics Simulation; Mutagens; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Oligonucleotides | 2010 |
Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Catechin; Deoxyguanosine; DNA Damage; Docosahexaenoic Acids; Lipid Peroxidation; Thioctic Acid | 2010 |
Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage.
Topics: Acrolein; Amines; Cyclopropanes; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Repair; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligopeptides | 2010 |
Formation of deoxyguanosine cross-links from calf thymus DNA treated with acrolein and 4-hydroxy-2-nonenal.
Topics: Acrolein; Aldehydes; Animals; Cattle; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2010 |
Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers.
Topics: Acrolein; Adult; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Female; Humans; Leukocytes; Male; Middle Aged; Smoking; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tumor Suppressor Protein p53 | 2011 |
γ-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage.
Topics: Acrolein; Amines; Amino Acid Sequence; Deoxyguanosine; DNA Adducts; Hydrogen Bonding; Imines; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Oligodeoxyribonucleotides; Peptides; Transition Temperature | 2011 |
Regioselective formation of acrolein-derived cyclic 1,N(2)-propanodeoxyguanosine adducts mediated by amino acids, proteins, and cell lysates.
Topics: Acrolein; Amino Acids; Animals; Borohydrides; Cell Line; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; Histones; Humans; Liver; Oxidation-Reduction; Proteins; Rats; Serum Albumin, Bovine; Smoking; Spermidine; Stereoisomerism | 2012 |
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Topics: Acrolein; Benzimidazoles; Biphenyl Compounds; Cell Line, Transformed; Cell Survival; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Indoles; Nucleic Acid Synthesis Inhibitors; Small Molecule Libraries; Terpenes; Tetrazoles; Ultraviolet Rays | 2012 |
Changes in nitrosative stress biomarkers in swine intestine following dietary intervention with verbascoside.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Animal Feed; Animals; Antioxidants; Biomarkers; Deoxyguanosine; Diet; Diet Therapy; Duodenum; Free Radicals; Glucosides; Jejunum; Male; Nitrosation; Oxidative Stress; Phenols; Swine; Tyrosine | 2013 |
Translesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γ.
Topics: Acrolein; Catalytic Domain; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Polymerase gamma; DNA Replication; DNA-Directed DNA Polymerase; Humans; Lipid Peroxidation; Mitochondria; Models, Chemical; Mutagenesis; Oligonucleotides; Oxidative Stress | 2013 |
Mitochondria-targeted antioxidant peptide SS31 protects the retinas of diabetic rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Animals; Antioxidants; Blood Glucose; Blood-Retinal Barrier; Body Weight; Capillaries; Claudin-5; Deoxyguanosine; Diabetes Mellitus, Experimental; Endoplasmic Reticulum; Male; Mitochondria; Occludin; Oligopeptides; Oxidative Stress; Protective Agents; Protein Transport; Rats; Rats, Sprague-Dawley; Retina; Signal Transduction; Tyrosine; Vascular Endothelial Growth Factor Receptor-2 | 2013 |
Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB.
Topics: Acrolein; Borohydrides; Chromatography, High Pressure Liquid; Deoxyguanosine; DNA; DNA Adducts; DNA Repair; DNA, Single-Stranded; Escherichia coli Proteins; Malondialdehyde; Mixed Function Oxygenases; Oligonucleotides; Tandem Mass Spectrometry | 2014 |
Acrolein-induced oxidative stress and genotoxicity in rats: protective effects of whey protein and conjugated linoleic acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Animals; Antioxidants; Biomarkers; Cytoprotection; Deoxyguanosine; DNA Damage; Emperipolesis; Environmental Pollutants; Erythrocytes; Glutathione; Leukocytes, Mononuclear; Linoleic Acids, Conjugated; Male; Megakaryocytes; Micronuclei, Chromosome-Defective; Oxidative Stress; Protein Carbonylation; Rats, Sprague-Dawley; Risk Assessment; Spleen; Thiobarbituric Acid Reactive Substances; Thymus Gland; Whey Proteins | 2018 |
Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.
Topics: Acrolein; Amino Acid Substitution; Cell Line; Deoxyguanosine; DNA Adducts; DNA Damage; DNA Polymerase iota; DNA Replication; DNA-Directed DNA Polymerase; Environmental Pollutants; Humans; Mutagens; Mutation; Nuclear Proteins; Nucleotidyltransferases; Organophosphorus Compounds; Protein Multimerization; Recombinant Fusion Proteins; Recombinant Proteins; RNA Interference | 2018 |
Identification and distinction of acrolein-deoxyguanosine adduct isomers by high-performance liquid chromatography/ion mobility spectrometry/quadrupole time-of-flight mass spectrometry combined with in-source collision-induced dissociation.
Topics: Acrolein; Chromatography, High Pressure Liquid; Deoxyguanosine; Ion Mobility Spectrometry; Isomerism; Mass Spectrometry | 2020 |