Page last updated: 2024-08-18

acrolein and cysteine

acrolein has been researched along with cysteine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19905 (13.16)18.7374
1990's2 (5.26)18.2507
2000's13 (34.21)29.6817
2010's11 (28.95)24.3611
2020's7 (18.42)2.80

Authors

AuthorsStudies
Parker, CM; Smith, GG; Sprince, H1
Ertl, A; Esterbauer, H; Schauenstein, E; Tillian, HM1
Giles, PM1
Sprince, H1
Gurtoo, HL; Hipkens, JH; Sharma, SD1
Atzori, L; Dypbukt, JM; Edman, CC; Grafström, RC1
Baburina, I; Dikdan, G; Guo, F; Jordan, F; Root, B; Tous, GI1
Alonso-Varona, A; Bilbao, P; Calle, Y; Castro, B; del Olmo, M; Palomares, T1
Carbone, DL; Doorn, JA; Kiebler, Z; Petersen, DR1
Heuvelmans, S; Hristova, M; van der Vliet, A1
Caterina, MJ1
Cravatt, BF; Dubin, AE; Evans, MJ; Macpherson, LJ; Marr, F; Patapoutian, A; Schultz, PG1
Aldini, G; Carini, M; Colombo, R; Dalle-Donne, I; Gamberoni, L; Giustarini, D; Maffei Facino, R; Milzani, A; Rossi, R; Vistoli, G1
Freed, BM; Harvey, J; Jonscher, K; Lambert, C; Li, J; Quintana, M; Reigan, P; Yang, TC1
Das, S; Gavin, T; Geohagen, BC; LoPachin, RM1
Aiuchi, T; Itabe, H; Kato, R; Masuda, Y; Obama, T; Takahashi, K1
Gugliucci, A; Kimura, S; Kinugasa, E; Lunceford, N; Ogata, H; Schulze, J1
Gugliucci, A1
Bhatnagar, A; Cai, J; Pierce, WM1
Hiraoka, E; Mano, J; Miyatake, F; Tamoi, M1
Dohmae, N; Igarashi, K; Kashiwagi, K; Nakamura, M; Saiki, R; Sakamoto, A; Suzuki, T; Terui, Y; Tomitori, H1
George, RC; Graves, DJ; Lew, J1
Chen, J; Hu, L; Liu, L; Shi, Z; Wang, D; Xue, Y1
Tanii, H1
Bauer, RA; Danyal, K; de Jong, W; Habibovic, A; Heppner, DE; Hristova, M; Little, AC; O'Brien, E; van der Vliet, A1
Ahmed, I; Chen, G; Li, Z; Lin, H; Lv, L; Mi, N1
Cheng, K; Li, C; Liu, M; Tang, L; Wang, H; Wang, W; Yang, Y; Zhou, W1
Afonso, CB; Pitt, AR; Sousa, BC; Spickett, CM1
Elmeligy, E; Higashi, T; Kuge, Y; Mai, Y; Mazaki, Y; Miwa, S; Noya, Y; Terada, K1
Ahmed, T; Ashman, J; Dann, WL; Durand, T; Guy, A; Pitt, AR; Sousa, BC; Spickett, CM1
Cosa, G; Lincoln, R; Van Kessel, ATM; Zhang, W1
Fei, J; Jiang, K; Ou, J; Ou, S; Shi, L; Yin, Z; Zheng, J1
Hamada, Y; Ikeda, H; Mekata, H; Minamino, Y; Miyazaki, H; Takaishi, H; Takaishi, M; Usui, K; Yamashita, K1
Fujita, M; Kasahara, T; Suzuki, K; Watanabe, K; Yamamoto, Y1
Cha, H; Chen, Y; Cho, AE; Crowley, L; Eun Moon, J; Han Chang, M; Hee Jo, E; Hee Lee, S; Hoon Pan, J; Hyun Park, J; Hyup Lee, J; Jin Lim, Y; Kim, HW; Kyeom Kim, J; Le, B; Li, Y; Nukhet, AB; Pil Pack, S; Rae Cho, Y; Zhao, J; Zhong, Y1
Davies, MJ; Sauerland, MB1
Chen, W; Cheng, M; Fan, L; Liu, W; Ma, J; Nie, X; Qiu, W; Song, J; Wang, B; Wang, X; Yang, M; Ye, Z; Yu, L; Zhou, M1
Higashi, K; Igarashi, K; Ishii, I; Kashiwagi, K; Nakamura, M; Sakamoto, A; Shimekake, M; Terui, Y; Uchida, M; Uemura, T1

Reviews

1 review(s) available for acrolein and cysteine

ArticleYear
Electrophile versus oxidant modification of cysteine residues: Kinetics as a key driver of protein modification.
    Archives of biochemistry and biophysics, 2022, 09-30, Volume: 727

    Topics: Acrolein; Aldehydes; Cysteine; Dimethyl Fumarate; Humans; Hydrogen Peroxide; Kinetics; Oxidants

2022

Other Studies

37 other study(ies) available for acrolein and cysteine

ArticleYear
Comparison of protection by L-ascorbic acid, L-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: implications in smoking.
    Agents and actions, 1979, Volume: 9, Issue:4

    Topics: Acetaldehyde; Acrolein; Adrenergic beta-Antagonists; Aldehydes; Anesthesia; Animals; Ascorbic Acid; Cysteine; Formaldehyde; Humans; Infant, Newborn; Male; Pain; Rats; Respiratory Distress Syndrome, Newborn; Smoking; Time Factors

1979
Therapeutic effects of cysteine adducts of alpha, beta-unsaturated aldehydes on Ehrlich ascites tumor of mice.
    European journal of cancer, 1976, Volume: 12, Issue:12

    Topics: Acrolein; Aldehydes; Animals; Binding Sites; Carcinoma, Ehrlich Tumor; Cysteine; Female; Male; Mice

1976
The biosynthesis of 3-hydroxypropylmercapturic acid from cyclophosphamide.
    Xenobiotica; the fate of foreign compounds in biological systems, 1979, Volume: 9, Issue:12

    Topics: Acetylcysteine; Acrolein; Animals; Bile; Chromatography, Paper; Cyclophosphamide; Cysteine; Glutathione; Liver; Rats

1979
Protective action of sulfur compounds against aldehyde toxicants of cigarette smoke.
    European journal of respiratory diseases. Supplement, 1985, Volume: 139

    Topics: Acetaldehyde; Acetylcysteine; Acrolein; Aldehydes; Animals; Cysteine; Formaldehyde; Lethal Dose 50; Male; Nicotiana; Plants, Toxic; Rats; Respiratory System; Smoke; Sulfur

1985
Role of glutathione in the metabolism-dependent toxicity and chemotherapy of cyclophosphamide.
    Cancer research, 1981, Volume: 41, Issue:9 Pt 1

    Topics: Acrolein; Alanine; Animals; Body Weight; Carcinoma 256, Walker; Cyclophosphamide; Cysteine; Female; Glutathione; Hematuria; Infusions, Parenteral; Liver; Male; Mice; Rats; Time Factors

1981
Thiol status and cytopathological effects of acrolein in normal and xeroderma pigmentosum skin fibroblasts.
    Carcinogenesis, 1993, Volume: 14, Issue:5

    Topics: Acrolein; Cell Line; Cysteine; DNA Damage; Dose-Response Relationship, Drug; Fibroblasts; Glutathione; Humans; Oxidation-Reduction; Proteins; Skin; Sulfhydryl Compounds; Xeroderma Pigmentosum

1993
Reactivity at the substrate activation site of yeast pyruvate decarboxylase: inhibition by distortion of domain interactions.
    Biochemistry, 1998, Feb-03, Volume: 37, Issue:5

    Topics: Acrolein; Amino Acid Sequence; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cysteine; Enzyme Activation; Fatty Acids, Monounsaturated; Glyoxylates; Kinetics; Maleates; Malonates; Molecular Sequence Data; Peptides; Protein Structure, Tertiary; Pyruvate Decarboxylase; Saccharomyces cerevisiae; Substrate Specificity; Sulfhydryl Reagents; Thiamine Pyrophosphate; Tritium

1998
Effects of L-2-oxothiazolidine-4-carboxylate on the cytotoxic activity and toxicity of cyclophosphamide in mice bearing B16F10 melanoma liver metastases.
    Melanoma research, 2000, Volume: 10, Issue:2

    Topics: Acrolein; Alkylation; Animals; Antineoplastic Agents, Alkylating; Biotransformation; Cell Division; Cyclophosphamide; Cysteine; Disease Progression; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glutathione; Leukopenia; Liver Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines

2000
Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase.
    Chemical research in toxicology, 2005, Volume: 18, Issue:8

    Topics: Acrolein; Aldehydes; Amino Acid Sequence; Animals; Blotting, Western; Central Nervous System Depressants; Cysteine; Diet; Dietary Fats; Electrophoresis, Gel, Two-Dimensional; Ethanol; Ethylmaleimide; Hydrolysis; Insulin; Lipid Peroxidation; Male; Mass Spectrometry; Molecular Sequence Data; Oxidation-Reduction; Protein Disulfide-Isomerases; Rats; Rats, Sprague-Dawley; Sulfhydryl Reagents; Trypsin

2005
GSH-dependent regulation of Fas-mediated caspase-8 activation by acrolein.
    FEBS letters, 2007, Feb-06, Volume: 581, Issue:3

    Topics: Acrolein; Alkylation; B-Lymphocytes; Buthionine Sulfoximine; Caspase 8; Caspase Inhibitors; Cell Line; Cysteine; Enzyme Activation; fas Receptor; Glutathione; Humans; Jurkat Cells; T-Lymphocytes

2007
Chemical biology: sticky spices.
    Nature, 2007, Feb-01, Volume: 445, Issue:7127

    Topics: Acrolein; Animals; Cysteine; Humans; Ion Channel Gating; Mice; Mustard Plant; Pain; Plant Oils; Spices; Taste; Transient Receptor Potential Channels

2007
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
    Nature, 2007, Feb-01, Volume: 445, Issue:7127

    Topics: Acrolein; Animals; Cysteine; Disulfides; Dithiothreitol; Electric Conductivity; Ethyl Methanesulfonate; Humans; Ion Channel Gating; Mice; Mustard Plant; Noxae; Pain; Plant Oils; Transient Receptor Potential Channels

2007
Actin Cys374 as a nucleophilic target of alpha,beta-unsaturated aldehydes.
    Free radical biology & medicine, 2007, Mar-01, Volume: 42, Issue:5

    Topics: Acrolein; Actin Cytoskeleton; Actins; Aldehydes; Animals; Cysteine; Mass Spectrometry; Models, Molecular; Peptide Mapping; Polymers; Protein Carbonylation; Rabbits

2007
Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kappaB1 DNA binding domain.
    The Journal of biological chemistry, 2007, Jul-06, Volume: 282, Issue:27

    Topics: Acrolein; Aldehydes; Arginine; Cells, Cultured; Cysteine; Cytokines; DNA; Gene Expression Regulation; Humans; Lung; NF-kappa B p50 Subunit; NFATC Transcription Factors; Nicotiana; Protein Binding; Respiratory Tract Infections; Smoke; T-Lymphocytes; Transcription Factor AP-1

2007
Neurotoxic mechanisms of electrophilic type-2 alkenes: soft soft interactions described by quantum mechanical parameters.
    Toxicological sciences : an official journal of the Society of Toxicology, 2007, Volume: 98, Issue:2

    Topics: 1-Propanol; Acrolein; Acrylamide; Acrylates; Alkenes; Animals; Butanones; Corpus Striatum; Cysteine; Dopamine; Ethylmaleimide; Male; Neurotoxicity Syndromes; Propanols; Quantum Theory; Rats; Rats, Sprague-Dawley; Synaptosomes

2007
Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS.
    Proteomics, 2007, Volume: 7, Issue:13

    Topics: Acrolein; Aldehydes; Amino Acid Sequence; Apolipoprotein B-100; Chloroform; Chromatography, Liquid; Copper Sulfate; Cysteine; Electrophoresis, Polyacrylamide Gel; Histidine; Humans; Kynurenine; Lipoproteins, LDL; Lysine; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Polyvinyls; Tandem Mass Spectrometry; Trypsin; Tryptophan

2007
Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients.
    Clinica chimica acta; international journal of clinical chemistry, 2007, Volume: 384, Issue:1-2

    Topics: Acetylcysteine; Acrolein; Aged; Aryldialkylphosphatase; Cysteine; Female; Humans; Kidney Failure, Chronic; Lipoproteins, HDL; Male; Middle Aged; Renal Dialysis; Treatment Outcome

2007
Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine.
    Life sciences, 2008, Feb-13, Volume: 82, Issue:7-8

    Topics: Acrolein; Antithrombins; Cysteine; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Homocysteine; Humans; Plasminogen; Time Factors

2008
Protein modification by acrolein: formation and stability of cysteine adducts.
    Chemical research in toxicology, 2009, Volume: 22, Issue:4

    Topics: Acrolein; Amino Acid Sequence; Animals; Cattle; Cysteine; Histidine; Hydrogen-Ion Concentration; Insulin; Lysine; Peptides; Schiff Bases; Spectrometry, Mass, Electrospray Ionization

2009
Evaluation of the toxicity of stress-related aldehydes to photosynthesis in chloroplasts.
    Planta, 2009, Volume: 230, Issue:4

    Topics: Acrolein; Aldehydes; Ascorbic Acid; Chloroplasts; Cysteine; Electron Transport; Enzyme Activation; Glutathione; Light; Oxidation-Reduction; Photosynthesis; Spinacia oleracea; Stress, Physiological

2009
Inactivation of GAPDH as one mechanism of acrolein toxicity.
    Biochemical and biophysical research communications, 2013, Jan-25, Volume: 430, Issue:4

    Topics: Acrolein; Amino Acid Sequence; Animals; Cell Line, Tumor; Cysteine; Glyceraldehyde-3-Phosphate Dehydrogenases; Mice; Molecular Sequence Data; Transformation, Genetic

2013
Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis.
    Journal of Alzheimer's disease : JAD, 2013, Volume: 36, Issue:1

    Topics: Acrolein; Alzheimer Disease; Animals; Catechin; Cattle; Cysteine; In Vitro Techniques; Microscopy, Electron, Transmission; Microtubules; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; tau Proteins; Tubulin

2013
Ca(2+) efflux is involved in cinnamaldehyde-induced growth inhibition of Phytophthora capsici.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Acrolein; Calcium; Cysteine; Dose-Response Relationship, Drug; Phytophthora; Propanols

2013
[Can a sensitizer potency be attenuated?].
    Sangyo eiseigaku zasshi = Journal of occupational health, 2015, Volume: 57, Issue:4

    Topics: Acrolein; Animals; Antioxidants; Brassicaceae; Carrier Proteins; Cysteine; Dinitrochlorobenzene; Haptens; Hazardous Substances; Humans; Isocyanates; Lysine; Mice; NF-E2-Related Factor 2; Occupational Exposure; Occupational Health; Oxidative Stress; Protein Binding; Reactive Oxygen Species; Skin Irritancy Tests; Tricarboxylic Acids

2015
Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.
    American journal of physiology. Lung cellular and molecular physiology, 2016, 11-01, Volume: 311, Issue:5

    Topics: Acrolein; Administration, Inhalation; Allergens; Animals; Bronchi; Calcium; Cysteine; Dual Oxidases; Enzyme Activation; Epithelial Cells; ErbB Receptors; Humans; Hydrogen Peroxide; Immunity, Innate; Interleukin-33; Mice, Inbred C57BL; NADPH Oxidases; Protein Carbonylation; Pyroglyphidae; src-Family Kinases; Sulfhydryl Compounds

2016
Allergenicity of acrolein-treated shrimp tropomyosin evaluated using RBL-2H3 cell and mouse model.
    Journal of the science of food and agriculture, 2018, Volume: 98, Issue:11

    Topics: Acrolein; Allergens; Animals; Cell Line; Cysteine; Female; Food Handling; Histamine; Humans; Immunoglobulin E; Immunoglobulin G; Leukotrienes; Mast Cells; Mice; Mice, Inbred BALB C; Penaeidae; Rats; Shellfish Hypersensitivity; Tropomyosin

2018
Acrolein-stressed threshold adaptation alters the molecular and metabolic bases of an engineered Saccharomyces cerevisiae to improve glutathione production.
    Scientific reports, 2018, 03-14, Volume: 8, Issue:1

    Topics: Acrolein; Adaptation, Biological; CRISPR-Cas Systems; Cysteine; Energy Metabolism; Gene Deletion; Gene Expression Regulation, Fungal; Genetic Engineering; Glutathione; Metabolic Networks and Pathways; Metabolome; Metabolomics; Saccharomyces cerevisiae; Stress, Physiological

2018
A mass spectrometry approach for the identification and localization of small aldehyde modifications of proteins.
    Archives of biochemistry and biophysics, 2018, 05-15, Volume: 646

    Topics: Acrolein; Aldehydes; Chromatography, Liquid; Cysteine; Histidine; Humans; Lysine; Muramidase; Oxidation-Reduction; Peptide Fragments; Serum Albumin, Human; Tandem Mass Spectrometry

2018
Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette smoke by direct reacting with unsaturated carbonyl compounds in the gas phase.
    Biochemical and biophysical research communications, 2019, 02-19, Volume: 509, Issue:4

    Topics: Acrolein; Aldehydes; Antioxidants; Chromatography, High Pressure Liquid; Cysteine; Environmental Pollutants; Gases; Glutathione; Ketones; Mass Spectrometry; Protein Carbonylation; Smoke; Tobacco Products

2019
Short-chain lipid peroxidation products form covalent adducts with pyruvate kinase and inhibit its activity in vitro and in breast cancer cells.
    Free radical biology & medicine, 2019, 11-20, Volume: 144

    Topics: Acrolein; Aldehydes; Animals; Apoptosis; Biocatalysis; Chromatography, Liquid; Cysteine; Dose-Response Relationship, Drug; Enzyme Assays; Humans; Kinetics; Lipid Peroxidation; Malondialdehyde; MCF-7 Cells; Muscle, Skeletal; Pyruvate Kinase; Rabbits; Structure-Activity Relationship; Tandem Mass Spectrometry

2019
A dormant BODIPY-acrolein singlet oxygen photosensitizer intracellularly activated upon adduct formation with cysteine residues.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2019, Aug-01, Volume: 18, Issue:8

    Topics: Acrolein; Boron Compounds; Cell Death; Coloring Agents; Cysteine; HeLa Cells; Humans; Light; Microscopy, Fluorescence; Molecular Structure; Photosensitizing Agents; Quantum Theory; Singlet Oxygen

2019
Formation of di-cysteine acrolein adduct decreases cytotoxicity of acrolein by ROS alleviation and apoptosis intervention.
    Journal of hazardous materials, 2020, 04-05, Volume: 387

    Topics: Acrolein; Apoptosis; Caco-2 Cells; Cell Survival; Cysteine; Humans; Reactive Oxygen Species

2020
Development of a chromophore-solid phase peptide reaction assay (C-SPRA) for assessing skin sensitization in vitro.
    The Analyst, 2020, May-07, Volume: 145, Issue:9

    Topics: Acrolein; Amino Acid Sequence; Animals; Benzothiazoles; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coloring Agents; Cysteine; Fluorescein-5-isothiocyanate; Immobilized Proteins; Lysine; Microspheres; Peptides; Skin; Sulfhydryl Compounds

2020
Cause Clarification of Cysteine Oxidation by Active Species Generated during the Oxidation Process of Cinnamaldehyde and Impact on an In Chemico Alternative Method for Skin Sensitization Using a Nucleophilic Reagent Containing Cysteine.
    Chemical research in toxicology, 2021, 07-19, Volume: 34, Issue:7

    Topics: Acrolein; Animals; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Cysteine; Humans; Indicators and Reagents; Oxidation-Reduction; Skin; Skin Irritancy Tests; Tandem Mass Spectrometry

2021
Sensitization of GSH synthesis by curcumin curtails acrolein-induced alveolar epithelial apoptosis via Keap1 cysteine conjugation: A randomized controlled trial and experimental animal model of pneumonitis.
    Journal of advanced research, 2023, Volume: 46

    Topics: Acrolein; Air Pollutants; Animals; Apoptosis; Body Weight; Curcumin; Cysteine; Cytokines; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Inbred C57BL; Models, Animal; NF-E2-Related Factor 2; Pneumonia; Pulmonary Disease, Chronic Obstructive

2023
Cross-sectional and longitudinal associations of acrolein exposure with pulmonary function alteration: Assessing the potential roles of oxidative DNA damage, inflammation, and pulmonary epithelium injury in a general adult population.
    Environment international, 2022, Volume: 167

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; Adult; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Cysteine; Epithelium; Humans; Inflammation; Oxidative Stress

2022
A search for acrolein scavengers among food components.
    Amino acids, 2023, Volume: 55, Issue:4

    Topics: Acrolein; Animals; Cysteine; Lysine; Mice; Quality of Life; Stroke

2023