acrolein has been researched along with 4-hydroxycyclophosphamide in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, N | 1 |
| Little, SA; Mirkes, PE | 1 |
| Borch, RF; Low, JE; Sladek, NE | 2 |
| Bielicki, L; Hohorst, HJ; Voelcker, G | 1 |
| Hales, BF | 1 |
| Borch, RF; Bratt, PM; Coveney, JR; Low, JE; Powers, JF; Sladek, NE; Smith, PC | 1 |
| DeLeve, LD | 1 |
| Kalhorn, TF; Ren, S; Slattery, JT | 1 |
| Ren, S; Slatterly, JT | 1 |
| Kawano, Y; Kurauchi, K; Miyahara, E; Nishikawa, T; Okamoto, Y | 1 |
| Araújo, AM; Bastos, ML; Carvalho, F; Costa, VM; Dionísio, F; Duarte-Araújo, M; Guedes de Pinho, P | 1 |
12 other study(ies) available for acrolein and 4-hydroxycyclophosphamide
| Article | Year |
|---|---|
Comparative pharmacologic study in vitro and in vivo with cyclophosphamide (NSC-26271), cyclophosphamide metabolites, and plain nitrogen mustard compounds.
Topics: Acrolein; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chlorides; Cyclophosphamide; In Vitro Techniques; Lethal Dose 50; Mammals; Methylation; Nitrogen Mustard Compounds; Rats; Sarcoma, Yoshida; Solutions; Structure-Activity Relationship | 1976 |
Relationship of DNA damage and embryotoxicity induced by 4-hydroperoxydechlorocyclophosphamide in postimplantation rat embryos.
Topics: Acrolein; Animals; Cyclophosphamide; DNA Damage; Dose-Response Relationship, Drug; Embryo Implantation; Embryo, Mammalian; Female; Glutathione; In Vitro Techniques; Phosphoramide Mustards; Rats; Rats, Inbred Strains | 1990 |
Further studies on the conversion of 4-hydroxyoxazaphosphorines to reactive mustards and acrolein in inorganic buffers.
Topics: Acrolein; Aldehydes; Buffers; Chemical Phenomena; Chemistry; Cyclophosphamide; Hydrogen-Ion Concentration; Ifosfamide; Kinetics; Nitrogen Mustard Compounds; Osmolar Concentration; Structure-Activity Relationship; Temperature | 1983 |
Activated cyclophosphamide: an enzyme-mechanism-based suicide inactivator of DNA polymerase/3'-5' exonuclease.
Topics: Acrolein; Alkylation; Animals; Biotransformation; Cyclophosphamide; DNA Polymerase I; Exodeoxyribonuclease V; Exodeoxyribonucleases; Humans | 1984 |
Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein.
Topics: Acrolein; Aldehydes; Animals; Cyclophosphamide; Drug Evaluation, Preclinical; Embryo, Mammalian; Female; Mutagenicity Tests; Mutagens; Mutation; Phosphoramide Mustards; Pregnancy; Rats; Rats, Inbred Strains; Salmonella typhimurium; Structure-Activity Relationship; Teratogens | 1982 |
Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis.
Topics: Acrolein; Biotransformation; Buffers; Chemical Phenomena; Chemistry; Cyclophosphamide; Humans; Hydrogen-Ion Concentration; Kinetics; Liver; Magnetic Resonance Spectroscopy; Phosphoramide Mustards | 1982 |
Influence of diuretics on urinary general base catalytic activity and cyclophosphamide-induced bladder toxicity.
Topics: Acrolein; Animals; Cyclophosphamide; Diuretics; Female; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Male; Organ Size; Rats; Rats, Inbred Strains; Spleen; Urinary Bladder | 1982 |
Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation.
Topics: Acrolein; Animals; Biotransformation; Coculture Techniques; Cyclophosphamide; Dose-Response Relationship, Drug; Endothelium; Glutathione; Hepatic Veno-Occlusive Disease; Immunosuppressive Agents; Liver; Male; Methionine; Mice; Mice, Inbred C3H; Serine; Time Factors | 1996 |
Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein.
Topics: Acrolein; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Cyclophosphamide; Cytosol; Enzyme Inhibitors; Humans; Isoenzymes; Liver; Retinal Dehydrogenase | 1999 |
Inhibition of carboxyethylphosphoramide mustard formation from 4-hydroxycyclophosphamide by carmustine.
Topics: Acrolein; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cyclophosphamide; Enzyme Inhibitors; Humans; In Vitro Techniques; Isocyanates; Isoenzymes; Liver; Phosphoramide Mustards; Retinal Dehydrogenase | 1999 |
Role of metabolites of cyclophosphamide in cardiotoxicity.
Topics: Acetylcysteine; Acrolein; Aldehyde Dehydrogenase; Animals; Apoptosis; Cardiotoxicity; Cardiotoxins; Cell Line; Cell Survival; Cyclophosphamide; Free Radical Scavengers; Immunosuppressive Agents; Myocytes, Cardiac; Phosphoramide Mustards; Rats; Reactive Oxygen Species | 2017 |
Cardiotoxicity of cyclophosphamide's metabolites: an in vitro metabolomics approach in AC16 human cardiomyocytes.
Topics: Acrolein; Antineoplastic Agents; Cardiotoxicity; Cell Line; Cyclophosphamide; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Metabolomics; Myocytes, Cardiac | 2022 |