acridines and braco-19
acridines has been researched along with braco-19 in 46 studies
Research
Studies (46)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (36.96) | 29.6817 |
| 2010's | 23 (50.00) | 24.3611 |
| 2020's | 6 (13.04) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gowan, SM; Harrison, JR; Kelland, LR; Neidle, S; Patterson, L; Read, MA; Valenti, M | 1 |
| Incles, CM; Kelland, LR; Neidle, S; Schultes, CM | 1 |
| Gomez, D; Lacroix, L; Lemarteleur, T; Mailliet, P; Mergny, JL; Riou, JF | 1 |
| Incles, CM; Kelland, LR; Kempski, H; Koehler, H; Neidle, S; Schultes, CM | 1 |
| Burger, AM; Dai, F; Double, JA; Moore, MJ; Neidle, S; Reszka, AP; Schultes, CM | 1 |
| Baldes, C; Kleideiter, E; Klotz, U; Lehr, CM; Mürdter, TE; Piotrowska, K; Schaefer, U; Taetz, S | 1 |
| Baldes, C; Bock, U; Haltner-Ukomadu, E; Huwer, H; Kleideiter, E; Klotz, U; Lehr, CM; Mueller, J; Mürdter, TE; Piotrowska, K; Schaefer, UF; Taetz, S | 1 |
| Greciano, O; Gunaratnam, M; Martins, C; Morjani, H; Neidle, S; Reszka, AP; Riou, JF; Schultes, CM | 1 |
| Baldes, C; Boettcher, S; Kleideiter, E; Klotz, U; Lehr, CM; Mürdter, TE; Piotrowska, K; Schaefer, UF; Taetz, S; Zapp, J | 1 |
| Kleideiter, E; Klotz, U; Piotrowska, K | 1 |
| Faller, DV; Rankin, AM; Spanjaard, RA | 1 |
| Campbell, NH; Neidle, S; Parkinson, GN; Reszka, AP | 1 |
| Huppert, JL | 1 |
| Fu, YT; Jarstfer, MB; Keppler, BR; Soares, J | 1 |
| Haider, SM; Neidle, S | 1 |
| Johnson, FB; Lieberman, PM; Norseen, J | 1 |
| Neidle, S | 1 |
| Debray, J; Demeunynck, M; Dheu-Andries, ML; Dumy, P; Jourdan, M; Monchaud, D; Teulade-Fichou, MP; Zeghida, W | 1 |
| Bertrand, H; Clifford, S; Granzhan, A; Guédin, A; Guillot, R; Mergny, JL; Monchaud, D; Saettel, N; Teulade-Fichou, MP | 1 |
| Haider, SM; Neidle, S; Parkinson, GN | 1 |
| Bare, GA; Liu, B; Sherman, JC | 1 |
| Alcaro, S; Artese, A; Costa, G; Ortuso, F; Parrotta, L | 1 |
| Amrane, S; Andreola, ML; Bedrat, A; Kerkour, A; Mergny, JL; Vialet, B | 1 |
| Armitage, BA; Gupta, A; Murphy, CT; Opresko, PL | 1 |
| Butovskaya, E; Daelemans, D; Palù, G; Pannecouque, C; Perrone, R; Richter, SN | 1 |
| Brabec, V; Fedorocko, P; Harvanova, D; Imrich, J; Janovec, L; Kasparkova, J; Koval, J; Kozurkova, M; Kristian, P; Mikes, J; Mikesová, L; Plsikova, J; Rosocha, J; Sabolova, D; Stramova, Z; Ungvarsky, J; Vojtickova, M | 1 |
| Artusi, S; Biasolo, MA; Calistri, A; Flamand, L; Nadai, M; Palù, G; Perrone, R; Richter, SN | 1 |
| Borges, F; Bourdoncle, A; Cabrera-Pérez, MA; Castillo-González, D; Cordeiro, MN; Cruz-Monteagudo, M; De Rache, A; Garrigues, T; Guédin, A; Introcaso, A; Mangiatordi, GF; Mergny, JL; Nicolotti, O; Pallardó, F; Paz-Y-Miño, C; Pérez-Machado, G; Tejera, E | 1 |
| Chen, Y; Cheng, Y; Li, Y; Liu, X; Ma, C; Wu, X; Xu, S; Yu, Z; Zhao, G; Zhou, G | 1 |
| Fan, Q; Li, C; Li, G; Mao, X; Tao, Y | 1 |
| Ganguly, B; Kanti Si, M; Sen, A | 1 |
| Artusi, S; Flamand, L; Gilbert-Girard, S; Gravel, A; Kaufer, BB; Richter, SN; Wallaschek, N | 1 |
| Abdelhamid, MAS; Gates, AJ; Waller, ZAE | 1 |
| Ganguly, B; Pramanik, SK; Si, MK | 1 |
| Deng, H; Gong, B; Li, Z; Liu, S; Niu, X; Wei, D; Yang, Z; Zhang, Y; Zhou, H | 1 |
| Machireddy, B; Sullivan, HJ; Wu, C | 1 |
| Joo, H; Phan, E; Rangel, VM; Singh, M; Tran, A; Wang, S; Xue, L; Yang, D | 1 |
| Frasson, I; Nadai, M; Richter, SN | 1 |
| Amato, J; Di Porzio, A; Iaccarino, N; Pagano, B; Randazzo, A | 1 |
| Butovskaya, E; Nadai, M; Richter, SN; Scalabrin, M; Soldà, P | 1 |
| Kumar Mishra, S; Kumar, A; Majee, P; Muniyappa, K; Nayak, D; Pandya, N; Pasadi, S; Shankar, U | 1 |
| Ganguly, B; Saha, A; Si, MK | 1 |
| Bambara, RA; Dewhurst, S; Maggirwar, SB; Piekna-Przybylska, D | 1 |
| Bartolini, M; Bua, G; Conti, I; Gallinella, G; Reggiani, A; Tedesco, D | 1 |
| D'Aria, F; Giancola, C; Pagano, B; Petraccone, L | 1 |
| Molnár, OR; Smeller, L; Somkuti, J; Végh, A | 1 |
Reviews
4 review(s) available for acridines and braco-19
| Article | Year |
|---|---|
Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity.
Topics: Acridines; Aminobenzoates; Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; Naphthalenes; Neoplasms; Oligonucleotides; Oligonucleotides, Antisense; Telomerase; Telomere; Tumor Cells, Cultured | 2008 |
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes.
Topics: Acridines; Base Pairing; Binding Sites; Chemistry, Pharmaceutical; G-Quadruplexes; Gene Targeting; Nucleic Acid Conformation; Nucleic Acids; Oxazoles; Porphyrins; Telomerase; Transcription, Genetic | 2008 |
Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer.
Topics: Acridines; Antineoplastic Agents; Drug Delivery Systems; G-Quadruplexes; Humans; Neoplasms; Nucleic Acid Conformation; Telomere | 2010 |
A structural analysis of G-quadruplex/ligand interactions.
Topics: Acridines; Binding Sites; Crystallography; Daunorubicin; Distamycins; G-Quadruplexes; Gene Expression Regulation; Ligands; Naphthalenes; Porphyrins; Telomere | 2011 |
Other Studies
42 other study(ies) available for acridines and braco-19
| Article | Year |
|---|---|
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
Topics: Acridines; Animals; Antineoplastic Agents; Cell Division; Disease Models, Animal; DNA; G-Quadruplexes; Humans; Immunocompromised Host; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Telomerase; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2002 |
Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
Topics: Acridines; Antineoplastic Agents; Catalytic Domain; Colonic Neoplasms; Cyclin D1; Cyclin T; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Drug Combinations; Drug Resistance, Neoplasm; Enzyme Inhibitors; Flavonoids; Humans; Piperidines; Telomerase; Telomere; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2003 |
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by hTERT RNA alternative splicing.
Topics: Acridines; Alternative Splicing; Cell Line, Tumor; Down-Regulation; Humans; Introns; Kinetics; Ligands; Oxazoles; Quinolinium Compounds; RNA; Substrate Specificity; Telomerase; Transcription, Genetic; Triazines | 2004 |
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.
Topics: 3T3 Cells; Acridines; Animals; Blotting, Western; Catalysis; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Chromosomes; Cyclin-Dependent Kinase Inhibitor p16; DNA; G-Quadruplexes; Humans; Ligands; Male; Metaphase; Mice; Models, Chemical; Nucleic Acid Conformation; Prostatic Neoplasms; Rhodamines; Telomerase; Telomere; Time Factors; Up-Regulation | 2004 |
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.
Topics: Acridines; Animals; Cell Line, Tumor; Cell Nucleus; Cytoplasm; DNA; DNA-Binding Proteins; DNA, Single-Stranded; Female; G-Quadruplexes; Guanine; Humans; Mice; Mice, Nude; Telomerase; Telomere; Ubiquitin; Uterine Neoplasms; Xenograft Model Antitumor Assays | 2005 |
Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors.
Topics: Acridines; Aminobenzoates; Biological Assay; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Naphthalenes; Oligonucleotides, Antisense; Polymerase Chain Reaction; Sensitivity and Specificity; Telomerase | 2005 |
Biopharmaceutical characterization of the telomerase inhibitor BRACO19.
Topics: Acridines; Antineoplastic Agents; Biological Transport; Caco-2 Cells; Cell Line; Cell Survival; Enzyme Inhibitors; Epithelial Cells; Humans; Permeability; Protein Binding; Solubility; Telomerase | 2006 |
Mechanism of acridine-based telomerase inhibition and telomere shortening.
Topics: Acridines; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; Humans; Molecular Structure; Telomerase; Telomere | 2007 |
Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential.
Topics: Acridines; Buffers; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Stability; Gene Amplification; Half-Life; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Solubility; Solvents; Spectrophotometry, Ultraviolet; Telomere; Temperature | 2008 |
Screening of telomerase inhibitors.
Topics: Acridines; Aminobenzoates; Bromodeoxyuridine; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Naphthalenes; Nucleic Acid Amplification Techniques; Telomerase; Telomere; Time Factors | 2007 |
Structural basis of DNA quadruplex recognition by an acridine drug.
Topics: Acridines; Binding Sites; Crystallography, X-Ray; DNA; G-Quadruplexes; Humans; Models, Molecular; TATA Box; Telomere | 2008 |
BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
Topics: Acridines; Circular Dichroism; Dimerization; G-Quadruplexes; Humans; Inhibitory Concentration 50; Shelterin Complex; Telomerase; Telomere; Telomere-Binding Proteins | 2009 |
A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes.
Topics: Acridines; Base Sequence; Binding Sites; Computer Simulation; DNA, Single-Stranded; G-Quadruplexes; Humans; Models, Molecular; Nucleic Acid Conformation; Tandem Repeat Sequences; Telomere | 2009 |
Role for G-quadruplex RNA binding by Epstein-Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment.
Topics: Acridines; Animals; Base Sequence; Binding Sites; Cell Line; Chromosomes, Human; DNA Replication; DNA, Viral; Epstein-Barr Virus Nuclear Antigens; G-Quadruplexes; HeLa Cells; Herpesvirus 4, Human; Humans; Metaphase; Molecular Sequence Data; Origin Recognition Complex | 2009 |
Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19.
Topics: Acridines; G-Quadruplexes; Ligands; Models, Molecular; Pyrimidines; Structure-Activity Relationship | 2009 |
Recognition of G-quadruplex DNA by triangular star-shaped compounds: with or without side chains?
Topics: Acridines; Azo Compounds; G-Quadruplexes; Heterocyclic Compounds; Ligands; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2011 |
Synthesis of a single G-quartet platform in water.
Topics: Acridines; Anthraquinones; Antineoplastic Agents; Carbazoles; DNA; G-Quadruplexes; Humans; Ligands; Models, Molecular; Perylene; Piperidines; Porphyrins; Water | 2013 |
Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.
Topics: Acridines; Chalcones; DNA; G-Quadruplexes; Humans; Hydrogen Bonding; Molecular Docking Simulation; ROC Curve; Small Molecule Libraries | 2013 |
Topology of a DNA G-quadruplex structure formed in the HIV-1 promoter: a potential target for anti-HIV drug development.
Topics: Acridines; Anti-HIV Agents; DNA, Viral; G-Quadruplexes; HIV-1; Ligands; Promoter Regions, Genetic; Structure-Activity Relationship | 2014 |
Hybridization of G-quadruplex-forming peptide nucleic acids to guanine-rich DNA templates inhibits DNA polymerase η extension.
Topics: Acridines; DNA; DNA-Directed DNA Polymerase; G-Quadruplexes; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Peptide Nucleic Acids; Protein Binding | 2014 |
Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19.
Topics: Acridines; Anti-HIV Agents; G-Quadruplexes; HIV-1; Inhibitory Concentration 50; Microbial Sensitivity Tests; Microbial Viability; Proviruses; Reverse Transcription; RNA, Viral | 2014 |
Novel trisubstituted acridines as human telomeric quadruplex binding ligands.
Topics: Acridines; Animals; Antineoplastic Agents; Cattle; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA; G-Quadruplexes; Humans; Ligands; Molecular Docking Simulation; Neoplasms | 2014 |
The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand.
Topics: Acridines; Antiviral Agents; DNA, Viral; G-Quadruplexes; Genome, Viral; Herpesvirus 1, Human; Humans; Virus Replication | 2015 |
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands.
Topics: Acridines; Cell Proliferation; Crystallography, X-Ray; Drug Discovery; Drug Evaluation, Preclinical; Fibroblasts; G-Quadruplexes; HeLa Cells; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Quantitative Structure-Activity Relationship; Telomere | 2015 |
Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.
Topics: Acridines; Apoptosis; Cell Proliferation; Cytostatic Agents; DNA Damage; G-Quadruplexes; Glioblastoma; Humans; Telomerase; Telomere; Tumor Cells, Cultured | 2016 |
Simple and fast screening of G-quadruplex ligands with electrochemical detection system.
Topics: Acridines; Antineoplastic Agents; Electrochemical Techniques; G-Quadruplexes; Hemin; Hydrogen Peroxide; Ligands; Porphyrins | 2016 |
Exploiting hydrogen bonding interactions to probe smaller linear and cyclic diamines binding to G-quadruplexes: a DFT and molecular dynamics study.
Topics: Acridines; Cyclohexylamines; Diamines; DNA; G-Quadruplexes; Hydrogen Bonding; Models, Chemical; Molecular Dynamics Simulation; Quantum Theory | 2017 |
Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.
Topics: Acridines; Cell Line; Circular Dichroism; G-Quadruplexes; Herpesvirus 6, Human; Humans; Nucleic Acid Conformation; Telomere; Virus Integration | 2017 |
Destabilization of i-Motif DNA at Neutral pH by G-Quadruplex Ligands.
Topics: Acridines; Aminoquinolines; Apoptosis Regulatory Proteins; Berberine; Circular Dichroism; G-Quadruplexes; Hydrogen-Ion Concentration; Ligands; Mitoxantrone; Nerve Tissue Proteins; Nucleotide Motifs; Picolinic Acids; Porphyrins; Transition Temperature | 2019 |
Tuning the ring strain effect in acridine derivatives on binding affinity with G-quadruplex-DNA: A computational and experimental study.
Topics: Acridines; Binding Sites; G-Quadruplexes; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Docking Simulation; Static Electricity; Thermodynamics | 2019 |
Intensive Distribution of G₂-Quaduplexes in the Pseudorabies Virus Genome and Their Sensitivity to Cations and G-Quadruplex Ligands.
Topics: 3' Untranslated Regions; 5' Untranslated Regions; Acridines; Aminoquinolines; Animals; Cattle; Cell Line; Computational Biology; DNA Helicases; DNA Primase; DNA, Viral; Epithelial Cells; G-Quadruplexes; Gene Expression Regulation, Viral; Genome, Viral; HEK293 Cells; Herpesvirus 1, Suid; Humans; Ligands; Mesoporphyrins; Picolinic Acids; Promoter Regions, Genetic; Protein Isoforms; Swine; Varicellovirus; Viral Proteins; Virus Activation; Virus Replication | 2019 |
Binding of BRACO19 to a Telomeric G-Quadruplex DNA Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent.
Topics: Acridines; Binding Sites; Cell Line, Tumor; Cytostatic Agents; DNA; G-Quadruplexes; Humans; Models, Molecular; Molecular Dynamics Simulation; Nucleic Acid Conformation; Solvents | 2019 |
Thiazole orange - Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19.
Topics: Acridines; Benzothiazoles; Biophysical Phenomena; Circular Dichroism; Enzyme Inhibitors; G-Quadruplexes; Humans; Quinolines; Spectrometry, Fluorescence; Spermine; Telomerase; Telomere | 2019 |
Conserved G-Quadruplexes Regulate the Immediate Early Promoters of Human
Topics: Acridines; Alphaherpesvirinae; Base Sequence; Conserved Sequence; DNA, Viral; G-Quadruplexes; Gene Expression Regulation, Viral; Genes, Immediate-Early; Humans; Models, Molecular; Promoter Regions, Genetic; Transcription, Genetic | 2019 |
Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry.
Topics: Acridines; Aminoquinolines; Circular Dichroism; DNA; Fluorometry; G-Quadruplexes; Humans; Ligands; Picolinic Acids; Proof of Concept Study; Transition Temperature | 2019 |
HIV-1 Nucleocapsid Protein Unfolds Stable RNA G-Quadruplexes in the Viral Genome and Is Inhibited by G-Quadruplex Ligands.
Topics: Acridines; Circular Dichroism; G-Quadruplexes; gag Gene Products, Human Immunodeficiency Virus; HIV-1; Ligands; Reverse Transcription; RNA Folding; RNA-Directed DNA Polymerase; RNA, Viral | 2019 |
Identification and characterization of two conserved G-quadruplex forming motifs in the Nipah virus genome and their interaction with G-quadruplex specific ligands.
Topics: Acridines; Antiviral Agents; Computational Biology; Conserved Sequence; G-Quadruplexes; Genome, Viral; Henipavirus Infections; Humans; Hydrogen Bonding; India; Ligands; Nipah Virus; Porphyrins; Virus Internalization; Virus Replication | 2020 |
Exploiting σ-hole interaction to design small uncharged ligand molecules to stabilize G-quadruplex-DNA: a computational study.
Topics: Acridines; G-Quadruplexes; Models, Molecular; Telomerase | 2020 |
G-quadruplex ligands targeting telomeres do not inhibit HIV promoter activity and cooperate with latency reversing agents in killing latently infected cells.
Topics: Acridines; Anti-HIV Agents; Apoptosis; Bryostatins; CD4-Positive T-Lymphocytes; DNA Damage; DNA Mismatch Repair; DNA Repair; Drug Synergism; Drug Therapy, Combination; G-Quadruplexes; HIV Infections; HIV-1; Host-Pathogen Interactions; Humans; Jurkat Cells; Ligands; Porphyrins; Promoter Regions, Genetic; Telomere; Telomere Homeostasis; Virus Activation; Virus Latency; Vorinostat | 2020 |
No G-Quadruplex Structures in the DNA of Parvovirus B19: Experimental Evidence versus Bioinformatic Predictions.
Topics: Acridines; Aminoquinolines; Antiviral Agents; Cells, Cultured; Circular Dichroism; Computational Biology; DNA, Viral; Erythroid Precursor Cells; G-Quadruplexes; Genome, Viral; Humans; Parvovirus B19, Human; Picolinic Acids; Virus Replication | 2020 |
Topics: Acridines; Antineoplastic Agents; Binding Sites; Calorimetry, Differential Scanning; Circular Dichroism; DNA; G-Quadruplexes; Guanine; Humans; Magnetic Resonance Spectroscopy; Oncogenes; Porphyrins; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins p21(ras); Thermodynamics | 2021 |
Characterization of a G-quadruplex from hepatitis B virus and its stabilization by binding TMPyP4, BRACO19 and PhenDC3.
Topics: Acridines; DNA; Fused-Ring Compounds; G-Quadruplexes; Genome, Viral; Hepatitis B virus; Ligands; Porphyrins; Thermodynamics | 2021 |