aconitine has been researched along with scoparone* in 1 studies
1 other study(ies) available for aconitine and scoparone
Article | Year |
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[Effects of 6,7-dimethoxycoumarin on experimental arrhythmia].
By using the arrhythmic animal models, the effect of 6,7-dimethoxycoumarin (DMOC) on arrhythmia was investigated. The arrhythmia in anaesthetized rat were induced by iv aconitine 20 micrograms.kg-1 or CaCl2 5 mg.kg-1. The arrhythmia in anesthetized guinea pigs was induced by iv ouabain 3.6 micrograms.kg-1.min-1. Procainamide (PA) was used as a positive control. DMOC (33-500 mg.kg-1, ig) and PA (100-800 mg.kg-1, ig) in anaesthetized rats could delay the time of onset of arrhythmia induced by aconitine. The ED50 of DMOC and PA for postponing the occurrence of ventricular extrasystole (VE) were 88 mg.kg-1 (95% confidence interval was 43-165 mg.kg-1) and 183 mg.kg-1 (95% confidence interval was 109-304 mg.kg-1), respectively. The results suggested that the anti-arrhythmia potency of DMOC was higher than that of PA (P < 0.01). Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coumarins; Electrocardiography; Female; Male; Mice; Ouabain; Procainamide; Rats; Rats, Wistar | 1993 |