aconitine and dimethylacetamide

A comparative study of the acute toxicity and antiarrhythmic activity of new domestic derivatives of dimethylacetamide showed that the introduction of amino and carboxylic acid residues into the structure of compounds is accompanied by reduction of the toxic properties of new substances on the average 2.73 times (p = 0.002) upon intraperitoneal introduction to animals. It has been established that the derivatives are able to prevent the formation of aconitine induced arrhythmias and eliminate the arrhythmia that occurs on the second day of myocardial infarction in dogs. Original derivatives of dimethylacetamide exhibit antiarrhythmic properties and their activity increases in proportion to the acute toxicity (r = 0.83, p = 0.0043).

Topics: Acetamides; Aconitine; Adjuvants, Immunologic; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cryoprotective Agents; Dogs; Dose-Response Relationship, Drug; Female; Male; Mice; Myocardial Infarction; Rats