aconitine and cloricromen

aconitine has been researched along with cloricromen* in 1 studies

Other Studies

1 other study(ies) available for aconitine and cloricromen

Article	Year
The action of AD6 on experimental arrhythmias and on action potentials of cardiac fibers. Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 281, Issue:1 AD6 is a coumarinic derivative which increases both coronary blood flow and prostacyclin production, while it decreases platelet responsiveness. We tested its action on experimental cardiac arrhythmias. AD6 (2.5-10 mg/kg) was able to antagonize the arrhythmogenic action of aconitine in rats and of adrenaline in cats. AD6 action was also tested in vitro. The drug (20-50 microM) prolonged the functional refractory period of guinea-pig atrial and ventricular muscle and lengthened the refractory period shortened by hypoxia. Intracellular electrophysiological experiments showed that AD6 prolongs action potential duration (APD) of guinea-pig atrial myocardium, sino-atrial node and cat Purkinje fibers. The results obtained in vitro may explain the effect on experimental arrhythmias, therefore suggesting a protective action on cardiac rhythm disturbances. Topics: Aconitine; Action Potentials; Animals; Arrhythmias, Cardiac; Cats; Chromonar; Coumarins; Epinephrine; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Sinoatrial Node	1986

Article

Year

The action of AD6 on experimental arrhythmias and on action potentials of cardiac fibers.

Archives internationales de pharmacodynamie et de therapie, 1986, Volume: 281, Issue:1

AD6 is a coumarinic derivative which increases both coronary blood flow and prostacyclin production, while it decreases platelet responsiveness. We tested its action on experimental cardiac arrhythmias. AD6 (2.5-10 mg/kg) was able to antagonize the arrhythmogenic action of aconitine in rats and of adrenaline in cats. AD6 action was also tested in vitro. The drug (20-50 microM) prolonged the functional refractory period of guinea-pig atrial and ventricular muscle and lengthened the refractory period shortened by hypoxia. Intracellular electrophysiological experiments showed that AD6 prolongs action potential duration (APD) of guinea-pig atrial myocardium, sino-atrial node and cat Purkinje fibers. The results obtained in vitro may explain the effect on experimental arrhythmias, therefore suggesting a protective action on cardiac rhythm disturbances.

Topics: Aconitine; Action Potentials; Animals; Arrhythmias, Cardiac; Cats; Chromonar; Coumarins; Epinephrine; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Sinoatrial Node

1986