aconitine has been researched along with cloricromen* in 1 studies
1 other study(ies) available for aconitine and cloricromen
Article | Year |
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The action of AD6 on experimental arrhythmias and on action potentials of cardiac fibers.
AD6 is a coumarinic derivative which increases both coronary blood flow and prostacyclin production, while it decreases platelet responsiveness. We tested its action on experimental cardiac arrhythmias. AD6 (2.5-10 mg/kg) was able to antagonize the arrhythmogenic action of aconitine in rats and of adrenaline in cats. AD6 action was also tested in vitro. The drug (20-50 microM) prolonged the functional refractory period of guinea-pig atrial and ventricular muscle and lengthened the refractory period shortened by hypoxia. Intracellular electrophysiological experiments showed that AD6 prolongs action potential duration (APD) of guinea-pig atrial myocardium, sino-atrial node and cat Purkinje fibers. The results obtained in vitro may explain the effect on experimental arrhythmias, therefore suggesting a protective action on cardiac rhythm disturbances. Topics: Aconitine; Action Potentials; Animals; Arrhythmias, Cardiac; Cats; Chromonar; Coumarins; Epinephrine; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Inbred Strains; Sinoatrial Node | 1986 |