Compounds > aclacinomycin
Page last updated: 2024-09-04

aclacinomycin and verapamil

aclacinomycin has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies
(aclacinomycin)		Trials
(aclacinomycin)		Recent Studies (post-2010)
(aclacinomycin)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
16882117,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyaclacinomycin (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coley, HM; Twentyman, PR; Workman, P2
Dong, J; Johdo, O; Naito, M; Seimiya, H; Tatsuta, T; Tsuruo, T1

Other Studies

3 other study(ies) available for aclacinomycin and verapamil

ArticleYear
Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A.
    Biochemical pharmacology, 1989, Dec-15, Volume: 38, Issue:24

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Cyclosporins; Doxorubicin; Drug Combinations; Drug Resistance; Humans; Mice; Tumor Cells, Cultured; Verapamil

1989
The efflux of anthracyclines in multidrug-resistant cell lines.
    Biochemical pharmacology, 1993, Oct-19, Volume: 46, Issue:8

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Membrane Glycoproteins; Mice; Phenotype; Tumor Cells, Cultured; Verapamil

1993
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
    Oncology research, 1995, Volume: 7, Issue:5

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Immunoblotting; Leukemia P388; Tumor Cells, Cultured; Verapamil; Vincristine

1995