Compounds > aclacinomycin
Page last updated: 2024-09-04

aclacinomycin and aclarubicin

aclacinomycin has been researched along with aclarubicin in 157 studies

Compound Research Comparison

Studies
(aclacinomycin)		Trials
(aclacinomycin)		Recent Studies (post-2010)
(aclacinomycin)		Studies
(aclarubicin)		Trials
(aclarubicin)		Recent Studies (post-2010) (aclarubicin)
16882182697105

Protein Interaction Comparison

ProteinTaxonomyaclacinomycin (IC50)aclarubicin (IC50)
72 kDa type IV collagenaseHomo sapiens (human)9.9
5-hydroxytryptamine receptor 2BHomo sapiens (human)1.106

Research

Studies (157)

TimeframeStudies, this research(%)All Research%
pre-199084 (53.50)18.7374
1990's37 (23.57)18.2507
2000's17 (10.83)29.6817
2010's12 (7.64)24.3611
2020's7 (4.46)2.80

Authors

AuthorsStudies
Umezawa, H2
Matsushima, T; Sawamura, M; Sugimura, T; Umezawa, K1
Bourut, C; Dantchev, D; Hayat, M; Mathé, G; Paintrand, M; Slioussartchouk, V1
Chinen, T; Horikoshi, N; Inagaki, J; Inoue, K; Nagura, E; Ogawa, M; Ueoka, H1
Crooke, ST; DuVernay, VH; Pachter, JA1
Inui, T; Kitamura, I; Ogasawara, T; Oki, T; Takeuchi, T; Umezawa, H; Yoshimoto, A1
Hirano, S; Hori, S; Inui, T; Ishizuka, M; Oki, T; Shirai, M; Takeuchi, T; Tsukagoshi, S; Umezawa, H1
Coley, HM; Twentyman, PR; Workman, P4
Benoist, H; Broglio, C; Desplaces, A; Dufer, J; Idoine, O; Jeannesson, P; Joly, P1
Chen, R; Chen, Y; Hu, Q; Jiao, H; Shen, W; Wang, H; Wang, Y; Zhou, M1
Garnier-Suillerot, A; Tarasiuk, J1
Anai, H; Kusumoto, H; Maehara, Y; Sugimachi, K; Takahashi, I; Yoshida, M1
Delius, M; Gambihler, S1
Chiba, T; Fukuhara, Y; Kakinuma, K; Katoh, M; Kitagawa, S; Shirai, T1
Klaffke, W; Springer, D; Thiem, J1
Izumi, H; Shirai, M; Yamagami, T1
Jacquot, R; Jardillier, JC; Jeannesson, P; Mayeux, P; Nyoung, MN; Trentesaux, C1
Diatchkovskaya, RF; Ganieva, LKh; Konovalova, NP; Lapshin, IM; Shapiro, AB; Volkova, LM1
Robinson, SH; Tsamadou, AI; Tsiftsoglou, AS; Wong, W1
Chiba, S; Kikuchi, M; Misago, M; Mori, N; Nagata, K; Nakata, K; Ogawa, R; Sato, T; Tsukada, J; Wake, A1
Maeda, H; Miyamoto, Y; Oda, T1
Frezard, F; Garnier-Suillerot, A1
Hayakawa, J; Kobayashi, Y; Okumura, F; Okutu, Y; Shibata, T; Suzuki, H; Usuda, Y; Yoshida, G1
Nishida, H; Takeuchi, T; Tone, H; Umezawa, H1
Kunimoto, S; Takeuchi, T; Umezawa, K1
Ebihara, T; Fukushima, M; Kawakami, S; Maruyama, K; Sawada, T; Tateyama, Y; Yoshimura, Y1
Li, LH; Yu, FL1
Sazuka, Y; Takino, Y; Tanizawa, H1
Asaki, S; Goto, Y; Kikuchi, T; Koizumi, M; Mochizuki, F; Nomura, N; Ohkubo, T; Satoh, J; Taima, T; Toyota, T1
Carman, MD; Gamba-Vitalo, C; Sartorelli, AC1
Kanai, M; Kanno, M; Kobayashi, K; Kondo, K; Matano, S; Matsuda, T; Nakamura, S; Ohtake, S; Okafuji, K; Yoshida, T1
Benoist, H; Carpentier, Y; Comoe, L; Desplaces, A; Dufer, J; Joly, P1
Sazuka, Y; Takino, Y; Tanizawa, H; Yoshikawa, K1
Ho, PT; Ishiguro, K; Sartorelli, AC1
Dornberger, K; Eckardt, K; Ihn, W; Schumann, G; Tresselt, D1
Frézard, F; Garnier-Suillerot, A; Gattegno, L; Tarasiuk, J1
Ahmed, K; Turk, JL1
Ishikawa, I; Kaneko, H; Katoh, M; Kojima, N; Shirai, T; Umeda, M; Yamaguchi, R; Yamauchi, M1
Kanematsu, T; Kusumoto, T; Maehara, Y; Sugimachi, K1
Balercia, G; Bravo-Cuellar, A; Levesque, JP; Liu, XH; Orbach-Arbouys, S; Osculati, F1
Takatsuki, A; Tamura, G1
Krc, I; Mlcochová, E; Myslivecek, M1
Feng, JB; Han, R; Li, ZR; Xia, LJ; Yin, MB1
Han, J; Jia, TZ; Liu, HY; Lu, Y; Yang, S; Zhong, GP1
Li, GR; Li, LH; Wang, YS1
Konno, T1
Mochizuki, T; Okazaki, T; Sawada, H; Tashima, M; Uchino, H1
Algara, DS; Cuellar, AB; Metzger, G; Orbach-Arbouys, S1
Anai, H; Kusumoto, H; Maehara, Y; Sugimachi, K1
Bravo-Cuellar, A; Cabannes, J; Homo-Delarche, F; Orbach-Arbouys, S1
Alessandrì, MG; Bertelli, AA; Giovannini, L; Mian, M; Scalori, V1
Alessandrì, MG; Giovannini, L; Mazzanti, L; Mian, M; Scalori, V1
Akazawa, N; Asahi, T; Hayata, S; Okita, K; Takeda, K; Tsugawa, M1
Ikeda, T; Shindo, H; Tsuboi, M1
Kadomoto, Y; Kajihara, H; Tahara, E; Yamahara, M; Yokozaki, H1
Ishii, E; Kato, Y; Matsuzaki, A; Miyazaki, S; Ueda, K1
Ehninger, G; Freund, M; Heil, G; Hoelzer, D; Kurrle, E; Link, H; Mitrou, PS1
Fink, FM; Gadner, H; Grümayer, ER; Kardos, G; Revesz, T; Schuler, D1
Andrade Mena, CE; Mathé, G; Orbach-Arbouys, S1
Hibi, S; Imashuku, S; Morimoto, S; Morioka, Y; Nakajima, T; Sugimoto, T; Todo, S1
Lutz, D1
Bachur, NR; Dodion, P; Egorin, MJ; Ferraro, TA; Riggs, CE; Tamburini, JM1
Marie, JP; Thevenin, D; Zittoun, R1
Bertelli, A; Ronca, G; Solaini, G1
Masaoka, T1
Ishizuka, M2
Ito, K; Kobayashi, K; Matsuda, T; Nakagoshi, T; Nakamura, E; Nakamura, S; Nakanishi, J; Natori, K; Ohtake, S; Yoshida, T1
Kubota, Y; Miura, T; Sakuramoto, T1
Lehotay, DC; Levey, BA; Levey, GS; Rogerson, BJ1
Crooke, ST; DuVernay, VH; Mong, S; Strong, JE1
Darzynkiewicz, Z; Melamed, MR; Staiano-Coico, L; Traganos, F1
Kanamori, T; Kimoto, T; Namba, M; Nobuhara, M; Tanaka, H; Yamamoto, S1
Kawamura, S; Maekawa, I; Miyake, T; Sasaki, H1
Gahrton, G1
Dickneite, G; Kurrle, R; Sedlacek, HH; Seiler, FR1
Andrade-Mena, CE; Berardet, M; Mathe, G; Orbach-Arbouys, S2
Feng, JB; Han, R; Li, ZR; Liang, F; Zeng, SX1
Homma, T; Min, KY; Nakagawa, H; Yoneda, S; Yoshida, S1
Collins, VP; Peterson, CO; Rudling, MJ1
Hattori, K; Kitao, T1
Yamada, K1
Mitrou, PS1
Fujii, M; Fujita, Y; Ishimitsu, T; Okabe, K; Toki, H1
Al-Sarraf, M; Kish, JA1
Kobayashi, M; Tahara, T1
Fujiwara, A; Hoshino, T; Sekine, Y1
Applefeld, MM; Bulkley, BH; Grochow, LB; Mader, LC; Taylor, AL; Wiernik, PH1
Tatsuta, K1
de Vassal, F; Delgado, M; Dorval, T; Gastiaburu, J; Goldschmidt, E; Hulhoven, R; Machover, D; Misset, JL; Ribaud, P; Tapiero, H1
Iguchi, H; Oki, T; Shibamoto, N; Shirai, M1
Gössinger, H; Lenzhofer, R; Moser, K; Rainer, H; Schneeweiss, B1
Bayssas, M; de Vassal, F; Delgado, M; Gil, MA; Gouveia, J; Hayat, M; Jasmin, C; Machover, D; Mathé, G; Misset, JL; Ribaud, P; Schwarzenberg, L1
Sato, H1
Matsuzawa, Y; Oki, T; Takeuchi, T; Umezawa, H; Yoshimoto, A1
Kitamura, I; Naganawa, H; Oki, T; Takeuchi, T; Tobe, H; Umezawa, H; Yoshimoto, A1
Inui, T; Miura, H; Mori, S; Oki, T; Shindo, N1
Hong, SK; Hong, YS; Hwang, CK; Kim, HS; Kim, SJ; Kim, YH; Lee, JJ1
Hayakawa, O; Kudo, R; Takehara, M1
Bao, D; Ji, X; Liu, X; Peng, Y; Wang, L1
Hakala, J; Lundell, J; Mäntsälä, P; Niemi, J; Ylihonko, K1
Asbury, RF; Cnaan, A; Haller, DG; Harris, J; Johnson, L; Zaentz, SD1
Wang, AH; Yang, D1
Abe, Y; Hatanaka, T; Ito, T; Kamiya, O; Nagata, K; Ohara, K; Ono, Y; Saito, M1
Broglio, C; Carpentier, Y; Desplaces, A; Dufer, J; Joly, P1
Aries, A; Jardillier, JC; Jeannesson, P; Morceau, F; Nyoung, MN; Ottolenghi, S; Ronchi, A; Trentesaux, C1
Dong, J; Johdo, O; Naito, M; Seimiya, H; Tatsuta, T; Tsuruo, T1
Aries, A; Devy, L; Jardillier, JC; Jeannesson, P; Lahlil, R; Morceau, F; Trentesaux, C1
Aries, A; Doubeikovski, A; Jardillier, JC; Jeannesson, P; Ottolenghi, S; Trentesaux, C1
Hong, YS; Kim, HS; Kim, YH; Lee, JJ; Yoo, OJ1
Kim, HS; Kim, YH; Lee, JJ; Yoo, OJ1
Chénais, B; Gillet, R; Jardillier, JC; Jeannesson, P; Morceau, F; Trentesaux, C1
Blanco, G; Hakala, J; Hautala, A; Kantola, J; Kunnari, T; Mäntsälä, P; Mendez, C; Salas, J; Ylihonko, K1
Aries, A; Chenais, B; Devy, L; Gillet, R; Jeannesson, P; Lahlil, R; Morceau, F; Trentesaux, C1
Chen, KQ; Jin, WM; Li, JX; Xu, Y; Yang, GH1
Billat, C; Devemy, E; Dupont, C; Gillet, R; Jeannesson, P; Trentesaux, C1
Airas, K; Hakala, J; Mäntsälä, P; Niemi, J; Wang, Y; Ylihonko, K1
Colige, A; Devy, L; Foidart, JM; Garnotel, R; Hollender, P; Jeannesson, P; Munaut, C; Noël, A1
Mäntsälä, P; Niemi, J; Wang, Y1
Egawa, K; Ito, T; Kurihara, Y; Matsumoto, M; Nose, K1
Hakala, J; Hautala, A; Kantola, J; Mäntsälä, P; Räty, K; Ylihonko, K1
Bobichon, H; Gillet, R; Trentesaux, C1
Kunnari, T; Mäntsälä, P; Metsä-Ketelä, M; Palmu, K; Ylihonko, K1
Jansson, A; Mäntsälä, P; Niemi, J; Schneider, G1
Cai, Z; Lin, MF; Wang, YG; Xiong, H1
Cheng, PF; Fei, Z; Liao, XL; Lou, B; Wu, MP; Yin, CY1
Meng, XL1
Kallio, P; Mäntsälä, P; Niemi, J; Schneider, G; Sultana, A1
Hu, M; Liu, YL; Shen, GL; Zhang, ZX1
Alexeev, I; Kursula, I; Mäntsälä, P; Niemi, J; Schneider, G; Sultana, A1
Alexeev, I; Mäntsälä, P; Niemi, J; Schneider, G; Sultana, A1
Buck, I; Cristofanon, S; Dicato, M; Diederich, M; Morceau, F; Reuter, S1
Cullen, SJ; Ponnappan, S; Ponnappan, U1
Duverger, A; Jones, J; Kappes, J; Kutsch, O; Shishido, T; Wagner, F; Wolschendorf, F1
Chang, CK; He, Q; Li, X; Song, LX; Wu, LY; Xu, L; Zhang, QX; Zhang, Y1
Chen, L; Mi, R; Wei, X; Yin, Q1
Cullen, S; Ponnappan, S; Ponnappan, U1
Bai, X; Guo, K; Guo, Z; He, H; He, X; Qiu, D; Wang, J; Weng, G; Xu, X; Ye, Y; Yi, W; Zhang, M; Zhou, R1
Cao, XM; Chen, YX; Gu, LF; He, AL; Lei, B; Liu, J; Ma, XR; Wang, FX; Wang, J; Wang, JL; Xu, Y; Yang, Y; Zhang, PY; Zhang, WG; Zhao, WH1
Cao, YB; DA, WM; Li, SW; Li, XH; Liu, B; Liu, ZY; Wu, XX; Wu, YM; Xu, LX; Yan, B; Yang, XL1
Atkinson, JP; Fermaintt, CS; Gao, N; Hasan, M; Jiang, S; Lehrman, MA; Li, QZ; Miyazaki, T; Morse, HC; Sakai, T; Yan, N1
Fan, C; Huang, J; Jin, J; Mai, W; Mao, L; Meng, H; Qian, W; Suo, S; Tong, H; Yu, W1
Hu, C; Jin, J; Lin, P; Lou, Y; Luo, Y; Ma, L; Mai, W; Mei, C; Meng, H; Qian, J; Qian, W; Ren, Y; Tong, H; Wei, J; Xie, L; Xu, G; Xu, W; Ye, L; Ye, X; Zhou, X1
Nesterov, VV; Shkolnik, EL; Shkolnik, LD; Varlan, GV; Vasyuk, YA1
Atkinson, JP; Fariss, R; Fermaintt, CS; Kim, YS; Kothari, PH; Kovalchuk, AL; Miyazaki, T; Morse, HC; Munasinghe, J; Perrino, FW; Qi, CF; Sakai, T; Shin, DM; Wang, H; Yan, N1
Bian, Y; Huang, C; Ma, S; Ma, W; Miao, L; Miao, M; Xia, F; Yu, D1
Hu, Y; Tang, GL; Yin, Y; Zhang, Z1
Jin, J; Li, J; Yu, W; Zhang, X1
Bo, J; Dou, L; Gao, C; Gao, X; Li, H; Liu, D; Lu, N; Wang, L; Wei, Y; Wu, Y; Zhang, R; Zhu, C1
Tian, P; Xu, Z1
Chang, J; Jin, J; Shen, YJ; Wang, HF; Ye, XN; Zhang, Y; Zhu, HH; Zhu, L1
Ahmad, K; Henikoff, S; Takushi, B; Wooten, M1

Reviews

6 review(s) available for aclacinomycin and aclarubicin

ArticleYear
Experimental studies on aclacinomycin.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:1

    Topics: Aclarubicin; Animals; Antineoplastic Combined Chemotherapy Protocols; Cricetinae; DNA; Drug Evaluation, Preclinical; Humans; Kinetics; Mice; Naphthacenes; Neoplasms, Experimental; RNA

1985
[Inhibitors affecting synthesis and intracellular translocation of glycoproteins as probes].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1985, Volume: 30, Issue:6

    Topics: 1-Deoxynojirimycin; Aclarubicin; Animals; Anthracyclines; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Bacitracin; Biological Transport; Glucosamine; Glycoproteins; Lipopeptides; Lysosomes; Monensin; Naphthacenes; Oligopeptides; Showdomycin; Tunicamycin

1985
Treatment of acute leukemia--advances in chemotherapy, immunotherapy, and bone marrow transplantation.
    Advances in cancer research, 1983, Volume: 40

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Age Factors; Aminoacridines; Amsacrine; Anthraquinones; Antibodies, Monoclonal; Azacitidine; Bone Marrow Transplantation; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Ifosfamide; Immunotherapy; Infant; Interferons; Leukemia; Leukemia, Lymphoid; Liposomes; Middle Aged; Mitoxantrone; Naphthacenes; Prognosis; Teniposide; Transplantation, Homologous; Transplantation, Isogeneic; Vinblastine; Vindesine

1983
Anthracyclines as tumor cell differentiating agents: effects on the regulation of erythroid gene expression.
    Leukemia & lymphoma, 1997, Volume: 26, Issue:5-6

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Carbohydrate Sequence; Cell Differentiation; Doxorubicin; Erythroid Precursor Cells; Gene Expression Regulation, Leukemic; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Molecular Sequence Data

1997
[Cardiooncology: Current Aspects of Prevention of Anthracycline Toxicity].
    Kardiologiia, 2016, Volume: 56, Issue:12

    Topics: Aclarubicin; Anthracyclines; Antibiotics, Antineoplastic; Cardiotoxicity; Doxorubicin; Epirubicin; Humans; Neoplasms

2016
Rethinking Biosynthesis of Aclacinomycin A.
    Molecules (Basel, Switzerland), 2023, Mar-18, Volume: 28, Issue:6

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Biosynthetic Pathways; Fermentation; Metabolic Engineering

2023

Trials

5 trial(s) available for aclacinomycin and aclarubicin

ArticleYear
[Randomized-controlled study of treatment with UFT-MMC or UFT-ACR in advanced gastric cancer. Tohoku Study Group of Cancer Treatment for the Digestive Organs].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:6

    Topics: Aclarubicin; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Japan; Male; Middle Aged; Mitomycin; Mitomycins; Multicenter Studies as Topic; Random Allocation; Remission Induction; Stomach Neoplasms; Tegafur; Uracil

1989
[New agents in the treatment of leukemia and lymphoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:4 Pt 2

    Topics: Aclarubicin; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Cytarabine; Doxorubicin; Drug Evaluation; Humans; Infusions, Parenteral; Leukemia, Myeloid, Acute; Lymphoma; Middle Aged; Naphthacenes

1983
An Eastern Cooperative Oncology Group phase II study of single agent DHAD, VP-16, aclacinomycin, or spirogermanium in metastatic pancreatic cancer.
    American journal of clinical oncology, 1994, Volume: 17, Issue:2

    Topics: Aclarubicin; Adenocarcinoma; Adjuvants, Immunologic; Antineoplastic Agents; Etoposide; Female; Humans; Male; Mitoxantrone; Organometallic Compounds; Pancreatic Neoplasms; Spiro Compounds; Survival Rate

1994
Clinical outcome of treatment with a combined regimen of decitabine and aclacinomycin/cytarabine for patients with refractory acute myeloid leukemia.
    Annals of hematology, 2012, Volume: 91, Issue:12

    Topics: Aclarubicin; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Survival; Cyclin-Dependent Kinase Inhibitor p15; Cytarabine; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Male; Middle Aged; Recurrence; Remission Induction; Survival Analysis; Tumor Cells, Cultured; Young Adult

2012
A phase II study of chidamide, cytarabine, aclarubicin, granulocyte colony-stimulating factor, and donor lymphocyte infusion for relapsed acute myeloid leukemia and myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation.
    Medical oncology (Northwood, London, England), 2023, Jan-10, Volume: 40, Issue:2

    Topics: Aclarubicin; Adult; Cytarabine; Graft vs Host Disease; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Lymphocytes; Myelodysplastic Syndromes; Recurrence

2023

Other Studies

146 other study(ies) available for aclacinomycin and aclarubicin

ArticleYear
Recent advances in antitumor antibiotics.
    Antibiotics and chemotherapy, 1978, Volume: 23

    Topics: Aclarubicin; Animals; Anthraquinones; Antibiotics, Antineoplastic; Bleomycin; Daunorubicin; DNA; Glycosides; Humans; Neoplasms; Structure-Activity Relationship; Zinostatin

1978
Mutagenicity of aclacinomycin A and daunomycin derivatives.
    Cancer research, 1978, Volume: 38, Issue:6

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Daunorubicin; Glycosides; Mutagens; Mutation; Naphthacenes; Salmonella typhimurium; Structure-Activity Relationship

1978
Electron microscopic studies of the heart and light microscopic studies of the skin after treatment of golden hamsters with adriamycin, detorubicin, AD-32, and aclacinomycin.
    Cancer treatment reports, 1979, Volume: 63, Issue:5

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Cricetinae; Daunorubicin; Doxorubicin; Drug Administration Schedule; Heart; Leukemia L1210; Mesocricetus; Microscopy, Electron; Myocardium; Naphthacenes; Skin

1979
Clinical study of aclacinomycin A.
    Cancer treatment reports, 1979, Volume: 63, Issue:5

    Topics: Aclarubicin; Adult; Aged; Antibiotics, Antineoplastic; Drug Evaluation; Female; Glycosides; Humans; Male; Middle Aged; Naphthacenes; Neoplasms

1979
Deoxyribonucleic acid binding studies on several new anthracycline antitumor antibiotics. Sequence preference and structure--activity relationships of marcellomycin and its analogues as compared to adriamycin.
    Biochemistry, 1979, Sep-04, Volume: 18, Issue:18

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; Base Sequence; Cattle; Chemical Phenomena; Chemistry; DNA; DNA, Bacterial; Doxorubicin; Kinetics; Naphthacenes; Polydeoxyribonucleotides; Salmon; Spectrometry, Fluorescence; Structure-Activity Relationship; Thymus Gland

1979
Enzymatic conversion of aclacinomycin A to Y by a specific oxidoreductase in Streptomyces.
    The Journal of antibiotics, 1979, Volume: 32, Issue:5

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Bacteria; Drug Resistance, Microbial; Naphthacenes; Oxidoreductases; Streptomyces

1979
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.
    Gan, 1977, Volume: 68, Issue:5

    Topics: Aclarubicin; Animals; Anthraquinones; Antibiotics, Antineoplastic; Cricetinae; Daunorubicin; Doxorubicin; Electrocardiography; Glycosides; Heart; Leukemia L1210; Leukemia, Experimental; Lymphoma, Non-Hodgkin; Male; Mesocricetus; Mice; Mice, Inbred Strains; Sarcoma 180; Sarcoma, Experimental; Streptomyces

1977
Further examination of 9-alkyl- and sugar-modified anthracyclines in the circumvention of multidrug resistance.
    Anti-cancer drug design, 1992, Volume: 7, Issue:6

    Topics: Aclarubicin; Animals; Carcinoma, Small Cell; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Structure-Activity Relationship; Tumor Cells, Cultured

1992
Studies on the susceptibility to NK-mediated lysis and the simultaneous expression of various surface molecules in anthracyclin-treated K562 cells and in four K562 cell clones.
    Immunology letters, 1992, Volume: 34, Issue:1

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Antigens, CD; Antigens, Surface; Cell Adhesion Molecules; Clone Cells; Cytotoxicity, Immunologic; Flow Cytometry; Glycophorins; Histocompatibility Antigens Class I; Humans; Killer Cells, Natural; Leukemia, Erythroblastic, Acute; Lewis X Antigen; Receptors, IgG; Receptors, Transferrin; Rosette Formation; Tumor Cells, Cultured

1992
Antitumor activity of siwenmycin: a novel anthracycline antibiotic.
    Pharmacology, 1992, Volume: 45, Issue:4

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; DNA, Neoplasm; Doxorubicin; HeLa Cells; Humans; Injections, Intraperitoneal; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred Strains; Mitolactol; Mitomycins; Neoplasm Metastasis; RNA, Neoplasm; Tumor Cells, Cultured

1992
Kinetic parameters for the uptake of anthracycline by drug-resistant and drug-sensitive K562 cells.
    European journal of biochemistry, 1992, Mar-01, Volume: 204, Issue:2

    Topics: Aclarubicin; Biological Transport; Cell Line; Cell Membrane; Doxorubicin; Drug Resistance; Fluorescence Polarization; Kinetics; Leukemia, Erythroblastic, Acute; Membrane Fluidity; Temperature

1992
Relationship between tumor histopathology and in vitro sensitivity to antitumor drugs in gastric cancer.
    Anti-cancer drugs, 1992, Volume: 3, Issue:1

    Topics: Aclarubicin; Adenocarcinoma; Antineoplastic Agents; Carbazilquinone; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Mitomycin; Neoplasm Invasiveness; Neoplasm Staging; Stomach Neoplasms

1992
In vitro interaction of lithotripter shock waves and cytotoxic drugs.
    British journal of cancer, 1992, Volume: 66, Issue:1

    Topics: Aclarubicin; Animals; Antineoplastic Agents; Cell Survival; Cisplatin; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Leukemia L1210; Lithotripsy; Mice; Tumor Cells, Cultured

1992
Aclacinomycin, an anti-leukemic anthracycline, impairs human neutrophil functions.
    International journal of hematology, 1991, Volume: 54, Issue:1

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Antineoplastic Agents; Humans; Membrane Potentials; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phagocytosis; Superoxides

1991
Approaches to the C-B-A trisaccharide of dihydroaclacinomycin by extending the chain from either side.
    Carbohydrate research, 1991, Sep-02, Volume: 216

    Topics: Aclarubicin; Carbohydrate Sequence; Molecular Sequence Data; Molecular Structure; Trisaccharides

1991
Experimental transplantation models of mouse sarcoma 180 in ICR mice for evaluation of anti-tumor drugs.
    The Journal of veterinary medical science, 1991, Volume: 53, Issue:4

    Topics: Aclarubicin; Animals; Antineoplastic Agents; Daunorubicin; Disease Models, Animal; Doxorubicin; Lung Neoplasms; Male; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Sarcoma 180; Skin Neoplasms; Specific Pathogen-Free Organisms

1991
Induction of erythropoietin receptors during aclacinomycin-mediated erythroid differentiation of K562 leukemia cells.
    Leukemia, 1991, Volume: 5, Issue:1

    Topics: Aclarubicin; Adjuvants, Immunologic; Binding Sites; Cell Differentiation; Erythroid Precursor Cells; Erythropoietin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute; Receptors, Cell Surface; Receptors, Erythropoietin

1991
Subrenal capsule assay of human tumor chemosensitivity.
    Neoplasma, 1991, Volume: 38, Issue:3

    Topics: Aclarubicin; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Evaluation Studies as Topic; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Subrenal Capsule Assay

1991
Cooperative effects of hemin and anthracyclines in promoting terminal erythroid maturation in K562 human erythroleukemia cells.
    Experimental hematology, 1991, Volume: 19, Issue:9

    Topics: Aclarubicin; Benzidines; Cell Differentiation; Drug Synergism; Erythroid Precursor Cells; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute; Tumor Cells, Cultured

1991
9-Alkyl, morpholinyl anthracyclines in the circumvention of multidrug resistance.
    European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:6

    Topics: Aclarubicin; Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Doxorubicin; Drug Resistance; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; Membrane Glycoproteins; Mice; Neoplasm Proteins; Tumor Cells, Cultured

1990
[Modified CHOP therapy in patients with non-Hodgkin's lymphoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:6

    Topics: Aclarubicin; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prednisone; Remission Induction; Survival Rate; Vincristine

1991
Comparison of the cytotoxic effects of the high- and low-molecular-weight anticancer agents on multidrug-resistant Chinese hamster ovary cells in vitro.
    Cancer research, 1990, Mar-01, Volume: 50, Issue:5

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Cell Line; Cisplatin; Doxorubicin; Drug Resistance; Fluorouracil; Maleates; Mitomycins; Molecular Weight; Polystyrenes; Ricin; Time Factors; Vinblastine; Zinostatin

1990
Comparison of the binding of anthracycline derivatives to purified DNA and to cell nuclei.
    Biochimica et biophysica acta, 1990, Nov-09, Volume: 1036, Issue:2

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Nucleus; Daunorubicin; DNA; Doxorubicin; Kinetics; Molecular Structure; Structure-Activity Relationship

1990
[Ventricular fibrillation after administration of aclacinomycin emulsion into mesenteric lymph nodes in a patient anesthetized with enflurane, nitrous oxide and oxygen].
    Masui. The Japanese journal of anesthesiology, 1990, Volume: 39, Issue:5

    Topics: Aclarubicin; Anesthesia, Inhalation; Enflurane; Humans; Injections, Intralymphatic; Male; Mesentery; Middle Aged; Nitrous Oxide; Oxygen; Ventricular Fibrillation

1990
Experimental studies of new anthracyclines: aclacinomycin, THP-adriamycin and ditrisarubicins.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1987, Volume: 41, Issue:5

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; Cricetinae; Doxorubicin; Heart; Leukemia L1210; Leukemia L5178; Mice; Myocardium; Naphthacenes; Rats; RNA

1987
[Balloon occluded arterial infusion (BOAI) therapy in patients with progressive cervical carcinoma].
    Nihon Sanka Fujinka Gakkai zasshi, 1989, Volume: 41, Issue:3

    Topics: Aclarubicin; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Catheterization; Cisplatin; Embolization, Therapeutic; Evaluation Studies as Topic; Female; Humans; Iliac Artery; Infusions, Intra-Arterial; Infusions, Intravenous; Infusions, Parenteral; Middle Aged; Platinum; Remission Induction; Tissue Distribution; Uterine Cervical Neoplasms

1989
Template specificities of aclacinomycin B on the inhibition of DNA-dependent RNA synthesis in vitro.
    Molecular and cellular biochemistry, 1989, Oct-05, Volume: 90, Issue:1

    Topics: Aclarubicin; Animals; DNA; DNA-Directed RNA Polymerases; Escherichia coli; Rats; RNA; Templates, Genetic; Transcription, Genetic

1989
Effect of adriamycin on DNA, RNA and protein biosyntheses in mouse tissues, in connection with its cardiotoxicity.
    Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:10

    Topics: Aclarubicin; Animals; Carcinoma, Ehrlich Tumor; Daunorubicin; DNA; Doxorubicin; Glutathione Peroxidase; Heart Diseases; Kidney; Lipid Peroxidation; Liver; Lung; Male; Mice; Myocardium; Protein Biosynthesis; RNA

1989
WEHI-3B D+ Y1 leukemia cells as a model system to assess the induction of differentiation in vivo.
    Cancer communications, 1989, Volume: 1, Issue:3

    Topics: Aclarubicin; Animals; Antineoplastic Agents; Cell Differentiation; Cell Line; Hematopoiesis; Kanamycin Kinase; Leukemia, Experimental; Mice; Mice, Inbred BALB C; Nucleic Acid Hybridization; Phosphotransferases; RNA, Messenger; Transfection

1989
Salvage chemotherapy of refractory non-Hodgkin's lymphoma with aclacinomycin, behenoyl ara-C, etoposide, and prednisolone.
    Cancer chemotherapy and pharmacology, 1989, Volume: 25, Issue:2

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Evaluation; Etoposide; Humans; Lymphoma, Non-Hodgkin; Neoplasm Recurrence, Local; Prednisolone; Remission Induction; Time Factors

1989
Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A.
    Biochemical pharmacology, 1989, Dec-15, Volume: 38, Issue:24

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Cyclosporins; Doxorubicin; Drug Combinations; Drug Resistance; Humans; Mice; Tumor Cells, Cultured; Verapamil

1989
Comparative effects of fagaronine, adriamycin and aclacinomycin on K562 cell sensitivity to natural-killer-mediated lysis. Lack of agreement between alteration of transferrin receptor and CD15 antigen expressions and induction of resistance to natural kil
    Cancer immunology, immunotherapy : CII, 1989, Volume: 30, Issue:5

    Topics: Aclarubicin; Alkaloids; Antigens, CD; Antineoplastic Agents; Benzophenanthridines; Cell Line; Cytotoxicity, Immunologic; Doxorubicin; Glycophorins; Hemoglobins; Humans; Immunity, Innate; Killer Cells, Natural; Leukemia, Erythroblastic, Acute; Phenanthridines; Receptors, Transferrin; Tumor Cells, Cultured

1989
Effect of aclacinomycin on lipid peroxide levels in tissues of mice.
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:12

    Topics: Aclarubicin; Animals; Lipid Peroxides; Mice; Microsomes, Liver

1989
Regulation of transferrin receptor in myeloid and monocytic differentiation of HL-60 leukemia cells.
    Cancer research, 1989, Apr-15, Volume: 49, Issue:8

    Topics: Aclarubicin; Cell Differentiation; Cell Division; Dimethyl Sulfoxide; Humans; Leukemia, Promyelocytic, Acute; Monocytes; Receptors, Transferrin; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured

1989
Aclacinomycin ZIMET 33352--a new anthracycline antibiotic.
    Journal of basic microbiology, 1989, Volume: 29, Issue:4

    Topics: Aclarubicin; Chemical Phenomena; Chemistry

1989
Anthracycline incorporation in human lymphocytes. Kinetics of uptake and nuclear concentration.
    Biochimica et biophysica acta, 1989, Sep-19, Volume: 1013, Issue:2

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Base Composition; Binding Sites; Blood Platelets; Carubicin; Cell Nucleus; DNA; Doxorubicin; Erythrocytes; Humans; Lymphocytes; Molecular Structure; Spectrometry, Fluorescence

1989
Effect of anticancer agents neothramycin, aclacinomycin, FK-565 and FK-156 on the release of interleukin-2 and interleukin-1 in vitro.
    Cancer immunology, immunotherapy : CII, 1989, Volume: 28, Issue:2

    Topics: Aclarubicin; Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzodiazepinones; Diaminopimelic Acid; Dose-Response Relationship, Immunologic; Interleukin-1; Interleukin-2; Male; Oligopeptides; Rats; Rats, Inbred Lew; Spleen

1989
[The effect of antileukemic drugs on superoxide (O2-) production by human neutrophils].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1987, Volume: 28, Issue:11

    Topics: Aclarubicin; Antineoplastic Agents; Cytarabine; Dose-Response Relationship, Drug; Humans; Leukemia; Naphthacenes; Neutrophils; Superoxides

1987
Sensitivity to six antitumor drugs differs between primary and metastatic liver cancers.
    European journal of cancer & clinical oncology, 1988, Volume: 24, Issue:9

    Topics: Aclarubicin; Antineoplastic Agents; Carbazilquinone; Carcinoma, Hepatocellular; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Liver Neoplasms; Male; Mitomycin; Mitomycins; Succinate Dehydrogenase

1988
Enhanced activity of peritoneal cells after aclacinomycin injection: effect of pretreatment with superoxide dismutase on aclacinomycin-induced cytological alterations and antitumoral activity.
    Cancer research, 1989, Mar-15, Volume: 49, Issue:6

    Topics: Aclarubicin; Animals; Cytotoxicity, Immunologic; Lipopolysaccharides; Luminescent Measurements; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Peritoneal Cavity; Superoxide Dismutase; Talc

1989
Combination therapy with aclacinomycin in acute leukemia.
    Acta Universitatis Palackianae Olomucensis Facultatis Medicae, 1986, Volume: 113

    Topics: Aclarubicin; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Humans; Leukemia; Naphthacenes; Thioguanine

1986
[Effect of aclacinomycin B on DNA polymerase II of tumor cells].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1985, Volume: 6, Issue:3

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; DNA Polymerase II; Leukemia L1210; Lung Neoplasms; Mice; Naphthacenes; Neoplasms, Experimental

1985
[Differentiation of human promyelocytic leukemic cells (HL-60) induced by aclacinomycin-B].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1986, Volume: 8, Issue:3

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Cell Differentiation; Cell Line; Humans; Leukemia, Myeloid, Acute; Naphthacenes

1986
[Effects of aclacinomycin B on nucleolar ultrastructure and function of RNA synthesis in human gastric cancer cells].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1987, Volume: 8, Issue:3

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Cell Line; Cell Nucleus; Humans; Naphthacenes; RNA, Neoplasm; Stomach Neoplasms

1987
[Targeting chemotherapy of hepatocellular carcinoma by arterial administration of anticancer agents dissolved in lipiodol].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:2

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Embolization, Therapeutic; Humans; Infusions, Intra-Arterial; Iodized Oil; Liver Neoplasms; Maleic Anhydrides; Mitomycin; Mitomycins; Naphthacenes; Polystyrenes; Zinostatin

1987
Magnesium deprivation inhibits the expression of differentiation-related phenotypes in human promyelocytic leukemia HL-60 cells.
    Journal of cellular physiology, 1987, Volume: 131, Issue:1

    Topics: Aclarubicin; Amanitins; Bucladesine; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Cycloheximide; Dimethyl Sulfoxide; Drug Interactions; Humans; Leucine; Leukemia, Myeloid, Acute; Magnesium Deficiency; Naphthacenes; Oncogenes; Peptide Chain Elongation, Translational; Phenotype; RNA, Messenger; Tetradecanoylphorbol Acetate; Tretinoin

1987
Enhanced activity of mouse peritoneal cells after aclacinomycin administration.
    Cancer research, 1987, Jul-01, Volume: 47, Issue:13

    Topics: Aclarubicin; Animals; Cytotoxicity, Immunologic; Free Radicals; Luminescent Measurements; Macrophage Activation; Macrophages; Mice; Naphthacenes; Neoplasms, Experimental; Peritoneal Cavity; Phagocytosis; Superoxides; Time Factors

1987
Poorly differentiated human gastric carcinoma is more sensitive to antitumor drugs than is well differentiated carcinoma.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 1987, Volume: 13, Issue:3

    Topics: Aclarubicin; Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Antineoplastic Agents; Carbazilquinone; Cisplatin; Doxorubicin; Fluorouracil; Humans; In Vitro Techniques; Mitomycin; Mitomycins; Naphthacenes; Stomach Neoplasms; Succinate Dehydrogenase

1987
Enhanced activity of murine peritoneal cells after aclacinomycin injection: characteristics of the enhanced respiratory burst.
    Cancer research, 1988, Jun-15, Volume: 48, Issue:12

    Topics: Aclarubicin; Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Dinoprostone; Luminescent Measurements; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naphthacenes; Oxygen Consumption; Peritoneal Cavity; Potassium Cyanide; Prostaglandins; Prostaglandins E

1988
Adriamycin, aclacinomycin and thepirubicin intracardiac distribution examined by fluorescence microscopy.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1988, Volume: 7, Issue:3

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Doxorubicin; Male; Microscopy, Fluorescence; Myocardium; Rats; Rats, Inbred Strains; Tissue Distribution

1988
Aclacinomycin tissue distribution in the rat.
    Chemioterapia : international journal of the Mediterranean Society of Chemotherapy, 1988, Volume: 7, Issue:1

    Topics: Aclarubicin; Adrenal Medulla; Animals; Antibiotics, Antineoplastic; Cell Nucleus; Kidney; Lung; Male; Naphthacenes; Pancreas; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Tissue Distribution

1988
[Treatment of advanced bladder cancer with intra-arterial infusion of cisplatinum (CDDP) and aclacinomycin (ACR), combined with angiotensin II].
    Hinyokika kiyo. Acta urologica Japonica, 1987, Volume: 33, Issue:8

    Topics: Aclarubicin; Aged; Aged, 80 and over; Angiotensin II; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Naphthacenes; Remission Induction; Urinary Bladder Neoplasms

1987
A velocity-gradient flow cell for Raman and emission spectroscopy of a deoxyribonucleic acid-drug solution.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:11

    Topics: Aclarubicin; Chemical Phenomena; Chemistry, Physical; DNA; Kinetics; Naphthacenes; Pharmaceutical Preparations; Spectrum Analysis, Raman

1987
Anthracycline induced myocardial damage. An analysis of 16 autopsy cases.
    Pathology, research and practice, 1986, Volume: 181, Issue:4

    Topics: Aclarubicin; Adult; Aged; Antibiotics, Antineoplastic; Cardiomyopathies; Daunorubicin; Doxorubicin; Female; Humans; Male; Middle Aged; Myocardium; Naphthacenes

1986
Treatment of juvenile chronic myelocytic leukemia with multidrug chemotherapy including aclacinomycin and N4-behenoyl-1-beta-D-arabinofuranosylcytosine.
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1986, Volume: 49, Issue:6

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Cytarabine; Humans; Leukemia, Myeloid; Male; Naphthacenes

1986
Age adapted induction and intensified consolidation therapy in acute myelogenous leukemia.
    Onkologie, 1986, Volume: 9, Issue:3

    Topics: Aclarubicin; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthacenes; Prognosis

1986
Aclacinomycin-A in the induction treatment of childhood AML.
    Onkologie, 1986, Volume: 9, Issue:3

    Topics: Aclarubicin; Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Daunorubicin; Etoposide; Female; Follow-Up Studies; Humans; Infant; Infusions, Parenteral; Leukemia, Myeloid, Acute; Male; Naphthacenes; Thioguanine

1986
Enhancement of NK-cell activity in normal and tumor-bearing mice after administration of aclacinomycin.
    Chemotherapy, 1986, Volume: 32, Issue:2

    Topics: Aclarubicin; Animals; Cells, Cultured; Drug Evaluation, Preclinical; Injections, Intraperitoneal; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Naphthacenes; Neoplasms, Experimental; Peritoneal Cavity; Spleen

1986
[Treatment of a case of childhood acute non-lymphocytic leukemia (ANLL) using high-dose cytosine arabinoside for intensification of early therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1987, Volume: 14, Issue:2

    Topics: Aclarubicin; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Female; Humans; Leukemia; Methotrexate; Naphthacenes; Vincristine

1987
[Various induction therapies in older patients with acute myeloid leukemias].
    Wiener klinische Wochenschrift, 1985, Feb-01, Volume: 97, Issue:3

    Topics: Aclarubicin; Adolescent; Adult; Aged; Aminoglutethimide; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Danazol; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Leukapheresis; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthacenes; Tamoxifen

1985
Comparative murine metabolism and disposition of class II anthracycline antibiotics.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:2

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; Chromatography, High Pressure Liquid; Computers; Male; Mice; Naphthacenes; Spectrometry, Fluorescence; Tissue Distribution

1985
In vitro sensitivity of leukemic clonogenic cells to four anthracyclines (adriamycin, daunorubicin, rubidazone and aclacinomycin) in human acute myeloid leukemia.
    Nouvelle revue francaise d'hematologie, 1985, Volume: 27, Issue:3

    Topics: Aclarubicin; Aged; Bone Marrow; Cells, Cultured; Child; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Humans; Leukemia, Myeloid, Acute; Middle Aged; Naphthacenes

1985
Studies on the effects of anthracyclines on mitochondrial respiration in vitro.
    Drugs under experimental and clinical research, 1985, Volume: 11, Issue:2

    Topics: Aclarubicin; Animals; Doxorubicin; Epirubicin; In Vitro Techniques; Male; Mitochondria, Heart; Naphthacenes; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Inbred Strains

1985
[Present status of the multidisciplinary treatment of acute leukemia].
    Gan no rinsho. Japan journal of cancer clinics, 1985, Volume: 31, Issue:9 Suppl

    Topics: Aclarubicin; Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Doxorubicin; Humans; Leukemia; Naphthacenes; Vincristine; Vindesine

1985
[Immunomodulation by antitumor antibiotics].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:3 Pt 2

    Topics: Aclarubicin; Animals; Anthramycin; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Benzodiazepinones; Guanidines; Immune Tolerance; Leukemia L1210; Mice; Naphthacenes; Peptides; Ribonucleosides

1986
[ABEP chemotherapy in the treatment of advanced non-Hodgkin's lymphomas].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1986, Volume: 13, Issue:4 Pt 1

    Topics: Aclarubicin; Adult; Aged; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Leukopenia; Lymphoma; Male; Middle Aged; Naphthacenes; Prednisolone; Thrombocytopenia; Vincristine

1986
[Sensitivity tests of anti-cancer drugs with human tumor stem cell assay. 2. The results in renal cell carcinoma and urothelial carcinoma].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1985, Volume: 76, Issue:5

    Topics: Aclarubicin; Antineoplastic Agents; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Colony-Forming Units Assay; Doxorubicin; Drug Evaluation, Preclinical; Humans; Kidney Neoplasms; Kidney Pelvis; Naphthacenes; Tumor Stem Cell Assay; Urinary Bladder Neoplasms; Vinblastine

1985
The effect of vivo doxorubicin (adriamycin) and aclacinomycin administration on guanylate cyclase activity in rat tissue.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1981, Volume: 167, Issue:4

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Doxorubicin; Ferric Compounds; Guanylate Cyclase; Liver; Male; Menogaril; Myocardium; Naphthacenes; Nogalamycin; Rats; Time Factors; Tissue Distribution

1981
Interaction of anthracyclines with covalently closed circular DNA.
    Molecular pharmacology, 1980, Volume: 17, Issue:1

    Topics: Aclarubicin; Anthracyclines; Antibiotics, Antineoplastic; Bleomycin; Carubicin; Centrifugation, Density Gradient; Daunorubicin; Diffusion; DNA, Circular; Doxorubicin; Drug Interactions; Electrophoresis, Agar Gel; Molecular Conformation; Naphthacenes

1980
Effects of aclacinomycin on cell survival and cell cycle progression of cultured mammalian cells.
    Cancer research, 1981, Volume: 41, Issue:7

    Topics: Aclarubicin; Animals; Cell Cycle; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Female; Interphase; Leukemia L1210; Mice; Mitosis; Naphthacenes; Ovary; RNA

1981
Recent studies on antibiotics and small molecular immunomodulators with potential usefulness in treating lung cancer: Part I - Antitumor antibiotics and their derivatives.
    International journal of clinical pharmacology, therapy, and toxicology, 1982, Volume: 20, Issue:1

    Topics: Aclarubicin; Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Bleomycin; Daunorubicin; Doxorubicin; Humans; Leukemia L1210; Lung; Lung Neoplasms; Mice; Molecular Weight; Naphthacenes; Peplomycin; Structure-Activity Relationship

1982
[Potentiation of the cytotoxic effects of various anticancer drugs by interferon on human neoplastic cells (HeLa) in culture].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:5

    Topics: Aclarubicin; Antineoplastic Agents; Bleomycin; Cell Division; Cisplatin; Doxorubicin; Drug Synergism; Fluorouracil; HeLa Cells; Humans; Interferons; Naphthacenes; Peplomycin

1983
[Comparative evaluation of combined chemotherapeutic regimens in acute non-lymphocytic leukemia].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1983, Volume: 58, Issue:3

    Topics: Aclarubicin; Acute Disease; Adult; Age Factors; Ancitabine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leukemia; Male; Mercaptopurine; Middle Aged; Naphthacenes; Prednisolone

1983
Immunosuppression as a desired pharmacological effect.
    Behring Institute Mitteilungen, 1984, Issue:74

    Topics: Aclarubicin; Anemia, Hemolytic; Animals; Antibiotics, Antineoplastic; Antibody Formation; Encephalomyelitis, Autoimmune, Experimental; Female; Glomerulonephritis; Graft vs Host Disease; Hemolytic Plaque Technique; Immune Complex Diseases; Immunity, Cellular; Immunosuppressive Agents; Mice; Mice, Inbred Strains; Naphthacenes; Rats; Rats, Inbred Lew

1984
Aclacinomycin inhibits suppressor cells in vivo and in vitro.
    Behring Institute Mitteilungen, 1984, Issue:74

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Antibody Formation; Antibody-Producing Cells; Immune Tolerance; Immunization, Passive; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Naphthacenes; Spleen; T-Lymphocytes, Regulatory

1984
[Effects of aclacinomycin B on biological macromolecular contents and synthesis of L1210 cells].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1984, Volume: 6, Issue:3

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; DNA, Neoplasm; Leukemia L1210; Mice; Naphthacenes; Neoplasm Proteins; RNA, Neoplasm

1984
[Aclacinomycin; benefits for the treatment of malignant pleural effusion].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:8

    Topics: Aclarubicin; Adenocarcinoma; Aged; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma, Small Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Naphthacenes; Pleural Effusion; Rabbits

1983
Delivery of aclacinomycin A to human glioma cells in vitro by the low-density lipoprotein pathway.
    Cancer research, 1983, Volume: 43, Issue:10

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Biological Availability; Cell Division; Chloroquine; Fibroblasts; Glioma; Humans; Lipoproteins, LDL; Naphthacenes; Receptors, Cell Surface; Receptors, LDL

1983
Inhibition of erythrocyte ATPase activity by aclacinomycin and reverse effects of ascorbate on ATPase activity.
    Experientia, 1983, Dec-15, Volume: 39, Issue:12

    Topics: Aclarubicin; Adenosine Triphosphatases; Ascorbic Acid; Calcium-Transporting ATPases; Erythrocyte Membrane; Humans; Naphthacenes; Ouabain; Sodium-Potassium-Exchanging ATPase

1983
[Therapeutic results with aclacinomycin A in recurring acute leukemias].
    Onkologie, 1983, Volume: 6, Issue:4

    Topics: Aclarubicin; Adolescent; Adult; Antibiotics, Antineoplastic; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthacenes; Recurrence

1983
[Efficacy of intrapleural treatment with aclacinomycin combined with closed tube thoracostomy for malignant pleural effusion].
    Gan no rinsho. Japan journal of cancer clinics, 1984, Volume: 30, Issue:8

    Topics: Aclarubicin; Adenocarcinoma; Adult; Aged; Drainage; Female; Humans; Intubation; Lung Neoplasms; Male; Middle Aged; Naphthacenes; Pleural Effusion; Thorax

1984
Aclacinomycin. Phase II evaluation in advanced squamous carcinoma of the head and neck.
    American journal of clinical oncology, 1984, Volume: 7, Issue:5

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Naphthacenes

1984
[Low molecular weight immunomodulators produced by microorganisms].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 2

    Topics: Aclarubicin; Adjuvants, Immunologic; Animals; Antibiotics, Antineoplastic; Concanavalin A; Glycine; Leucine; Lymphocyte Activation; Mice; Molecular Weight; Naphthacenes; Neoplasms, Experimental; Ribonucleosides

1984
[Adriamycin-aclacinomycin therapy (AA therapy) for acute leukemia unresponsive to BH-AC-DMP therapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1983, Volume: 10, Issue:6

    Topics: Aclarubicin; Adolescent; Adult; Aged; Cytarabine; Daunorubicin; Doxorubicin; Drug Resistance; Drug Therapy, Combination; Female; Humans; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Naphthacenes; Prednisolone

1983
Microbial conversion of anthracycline antibiotics. I. Microbial conversion of aclacinomycin B to aclacinomycin A.
    The Journal of antibiotics, 1983, Volume: 36, Issue:11

    Topics: Aclarubicin; Anti-Bacterial Agents; Chromatography, Thin Layer; Kinetics; Naphthacenes; Streptomyces; Structure-Activity Relationship

1983
Acute anthracycline cardiotoxicity. Comparative morphologic study of three analogues.
    Cancer, 1984, Apr-15, Volume: 53, Issue:8

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Cell Nucleus; Chemotherapy, Cancer, Regional Perfusion; Cytoplasm; Daunorubicin; Heart; Heart Diseases; Myocardium; Naphthacenes; Rabbits; Time Factors

1984
[New anthracycline antibiotics and derivatives].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 2

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; Daunorubicin; Doxorubicin; Leukemia L1210; Mice; Naphthacenes; Structure-Activity Relationship

1984
Phase I-II study of aclacinomycin for a treatment of acute myeloid leukemia.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1984, Volume: 38, Issue:7

    Topics: Aclarubicin; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Child; Child, Preschool; Drug Evaluation; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthacenes

1984
[Studies on the metabolism of aclacinomycin A (author's transl)].
    The Japanese journal of antibiotics, 1980, Volume: 33, Issue:2

    Topics: Aclarubicin; Animals; Brain; Cricetinae; Female; Guinea Pigs; Haplorhini; In Vitro Techniques; Liver; Lung; Male; Mice; NAD; NADP; Naphthacenes; Rabbits; Rats

1980
[Pilot studies with aclacinomycin in patients with breast cancer or gastrointestinal tumors].
    Wiener medizinische Wochenschrift (1946), 1983, Volume: 133, Issue:7

    Topics: Aclarubicin; Adult; Antibiotics, Antineoplastic; Breast Neoplasms; Doxorubicin; Female; Gastrointestinal Neoplasms; Heart Failure; Humans; Male; Middle Aged; Naphthacenes

1983
Phase II trial of aclacinomycin in acute leukemia and lymphosarcoma.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 74

    Topics: Aclarubicin; Adolescent; Adult; Aged; Antibiotics, Antineoplastic; Child; Drug Evaluation; Female; Humans; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Naphthacenes

1980
[Antitumor spectrum of aclacinomycin A, MA 144 N 1 and MA 144 S 1 on the rat ascitic hepatoma (author's transl)].
    The Japanese journal of antibiotics, 1980, Volume: 33, Issue:2

    Topics: Aclarubicin; Animals; Drug Evaluation, Preclinical; Female; Liver Neoplasms, Experimental; Naphthacenes; Rats

1980
Biosynthesis of anthracycline antibiotics by Streptomyces galilaeus. I. Glycosidation of various anthracyclinones by an aclacinomycin-negative mutant and biosynthesis of aclacinomycins from aklavinone.
    The Journal of antibiotics, 1980, Volume: 33, Issue:11

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Glycosides; Mutation; Naphthacenes; Streptomyces

1980
Potentiated immune responses after administration of aclacinomycin.
    International archives of allergy and applied immunology, 1982, Volume: 68, Issue:2

    Topics: Aclarubicin; Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; BCG Vaccine; Fibrosarcoma; Hemolytic Plaque Technique; Hypersensitivity, Delayed; Immunity, Cellular; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Naphthacenes; Sheep

1982
Biosynthesis of aklavinone and aclacinomycins.
    The Journal of antibiotics, 1981, Volume: 34, Issue:11

    Topics: Aclarubicin; Anti-Bacterial Agents; Naphthacenes; Streptomyces

1981
[Studies on the stability of aclacinomycin hydrochloride. I. Stability of solution of aclacinomycin hydrochloride (author's transl)].
    The Japanese journal of antibiotics, 1980, Volume: 33, Issue:4

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Drug Stability; Hot Temperature; Hydrogen-Ion Concentration; Ions; Light; Naphthacenes; Solutions; Water

1980
Expression of Streptomyces peucetius genes for doxorubicin resistance and aklavinone 11-hydroxylase in Streptomyces galilaeus ATCC 31133 and production of a hybrid aclacinomycin.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:7

    Topics: Aclarubicin; Aryl Hydrocarbon Hydroxylases; Carbohydrate Sequence; Doxorubicin; Drug Resistance, Microbial; Gene Expression; Genes, Bacterial; Humans; Molecular Sequence Data; Neoplasms; Streptomyces; Tumor Cells, Cultured

1995
[Experimental and clinical study on chemotherapy for cervical adenocarcinoma].
    Nihon Sanka Fujinka Gakkai zasshi, 1995, Volume: 47, Issue:4

    Topics: Aclarubicin; Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dactinomycin; Drug Administration Schedule; Etoposide; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitomycin; Neoplasm Transplantation; Uterine Cervical Neoplasms

1995
[Preliminary mechanism studies of siwenmycin on the inhibition of nucleic acid syntheses].
    Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 1993, Volume: 24, Issue:2

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Cattle; DNA; DNA Polymerase I; DNA-Directed RNA Polymerases; RNA

1993
The efflux of anthracyclines in multidrug-resistant cell lines.
    Biochemical pharmacology, 1993, Oct-19, Volume: 46, Issue:8

    Topics: Aclarubicin; Animals; Anthracyclines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance; Humans; Membrane Glycoproteins; Mice; Phenotype; Tumor Cells, Cultured; Verapamil

1993
Isolation and characterization of aclacinomycin A-non-producing Streptomyces galilaeus (ATCC 31615) mutants.
    Microbiology (Reading, England), 1994, Volume: 140 ( Pt 6)

    Topics: Acetates; Aclarubicin; Anthraquinones; Carbohydrate Sequence; Carbohydrates; Molecular Sequence Data; Molecular Structure; Mutagenesis; Naphthacenes; Propionates; Streptomyces

1994
Structure by NMR of antitumor drugs aclacinomycin A and B complexed to d(CGTACG).
    Biochemistry, 1994, May-31, Volume: 33, Issue:21

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Binding Sites; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oligodeoxyribonucleotides

1994
[Short-term intensive consolidation chemotherapy in the treatment of acute nonlymphocytic leukemia].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:2

    Topics: Aclarubicin; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Prognosis; Survival Rate; Vinblastine; Vincristine

1994
Quantitative morphological assessment of erythroblastic differentiation induced, in vitro, in human K562 leukemic cells.
    Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology, 1993, Volume: 5, Issue:3

    Topics: Aclarubicin; Alkaloids; Benzophenanthridines; Cell Differentiation; Erythroblasts; Hemin; Hemoglobins; Humans; Leukemia; Phenanthridines; Tumor Cells, Cultured

1993
Increased expression of GATA-1 and NFE-2 erythroid-specific transcription factors during aclacinomycin-mediated differentiation of human erythroleukemic cells.
    Leukemia, 1993, Volume: 7, Issue:3

    Topics: Aclarubicin; Adjuvants, Immunologic; Base Sequence; Binding Sites; Cell Differentiation; DNA Probes; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Gene Expression; Globins; HeLa Cells; Humans; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Sensitivity and Specificity; Transcription Factors

1993
Difference between the resistance mechanisms of aclacinomycin- and adriamycin-resistant P388 cell lines.
    Oncology research, 1995, Volume: 7, Issue:5

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Nucleus; DNA Topoisomerases, Type II; DNA, Neoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Humans; Immunoblotting; Leukemia P388; Tumor Cells, Cultured; Verapamil; Vincristine

1995
Evidence for distinct regulation processes in the aclacinomycin- and doxorubicin-mediated differentiation of human erythroleukemic cells.
    Biochemical pharmacology, 1996, Mar-22, Volume: 51, Issue:6

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Base Sequence; Cell Differentiation; DNA-Binding Proteins; Doxorubicin; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Gene Expression; Globins; Hemoglobins; Humans; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; NF-E2 Transcription Factor; NF-E2 Transcription Factor, p45 Subunit; Receptors, Erythropoietin; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured

1996
Activation of erythroid-specific promoters during anthracycline-induced differentiation of K562 cells.
    Blood, 1996, Apr-01, Volume: 87, Issue:7

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Base Sequence; Cell Differentiation; Doxorubicin; Erythropoiesis; Humans; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Promoter Regions, Genetic; Tumor Cells, Cultured

1996
New anthracycline metabolites produced by the aklavinone 11-hydroxylase gene in Streptomyces galilaeus ATCC 31133.
    The Journal of antibiotics, 1996, Volume: 49, Issue:4

    Topics: Aclarubicin; Anthracyclines; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Streptomyces

1996
Aclacinomycin X, a novel anthracycline antibiotic produced by Streptomyces galilaeus ATCC 31133.
    Bioscience, biotechnology, and biochemistry, 1996, Volume: 60, Issue:5

    Topics: Aclarubicin; Adjuvants, Immunologic; Antibiotics, Antineoplastic; Cell Division; Culture Media; Humans; Leukemia; Magnetic Resonance Spectroscopy; Melanoma; Streptomyces; Tumor Cells, Cultured

1996
Transcriptional and posttranscriptional regulation of erythroid gene expression in anthracycline-induced differentiation of human erythroleukemic cells.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1996, Volume: 7, Issue:8

    Topics: Aclarubicin; Anthracyclines; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Doxorubicin; Erythroid Precursor Cells; Erythroid-Specific DNA-Binding Factors; GATA1 Transcription Factor; Gene Expression; Globins; Humans; Hydroxymethylbilane Synthase; Nuclear Proteins; Protein Biosynthesis; Proteins; Receptors, Erythropoietin; RNA Processing, Post-Transcriptional; RNA, Messenger; Time Factors; Transcription Factors; Transcriptional Activation

1996
Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline.
    Chemistry & biology, 1997, Volume: 4, Issue:10

    Topics: Aclarubicin; Alcohol Oxidoreductases; Anthracyclines; Bacterial Proteins; Multienzyme Complexes; Multigene Family; Nogalamycin; Plicamycin; Protein Folding; Streptomyces

1997
Effect of topical aclacinomycin on glaucoma filtration surgery in rabbits.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1997, Volume: 13, Issue:6

    Topics: Aclarubicin; Animals; Antibiotics, Antineoplastic; Eye; Female; Filtering Surgery; Glaucoma; Intraocular Pressure; Intraoperative Care; Male; Rabbits

1997
Evidence of the role of protein kinase C during aclacinomycin induction of erythroid differentiation in K562 cells.
    FEBS letters, 1999, Jul-09, Volume: 454, Issue:3

    Topics: Aclarubicin; Adjuvants, Immunologic; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Erythroblasts; Humans; Indoles; K562 Cells; Maleimides; Protein Kinase C; Signal Transduction

1999
Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
    Biochimica et biophysica acta, 2000, Jul-14, Volume: 1480, Issue:1-2

    Topics: Aclarubicin; Base Sequence; Carboxylic Ester Hydrolases; Catalysis; DNA Primers; Mixed Function Oxygenases; Streptomyces

2000
Matrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid.
    Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2

    Topics: Aclarubicin; Antineoplastic Agents; Cell Differentiation; Cell Movement; HL-60 Cells; Humans; Leukemia; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Phenylalanine; Serine Endopeptidases; Thiophenes; Tissue Inhibitor of Metalloproteinases; Tretinoin; Tumor Cells, Cultured

2002
Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products.
    FEMS microbiology letters, 2002, Feb-19, Volume: 208, Issue:1

    Topics: Aclarubicin; Anthracyclines; Antibiotics, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Bacterial Proteins; Carboxylic Ester Hydrolases; Mixed Function Oxygenases; Mutation; Naphthacenes; Streptomyces; Substrate Specificity

2002
Induction of p16INK4a transcription and of cellular senescence by aclacinomycin-derivatives and cardiac glycosides.
    Biological & pharmaceutical bulletin, 2002, Volume: 25, Issue:4

    Topics: Aclarubicin; Cardiac Glycosides; Cells, Cultured; Cellular Senescence; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, p16; Humans; Transcription, Genetic; Tumor Cells, Cultured

2002
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
    Gene, 2002, Jun-26, Volume: 293, Issue:1-2

    Topics: Aclarubicin; Cloning, Molecular; DNA, Bacterial; Genes, Bacterial; Genetic Complementation Test; Multienzyme Complexes; Multigene Family; Mutation; Naphthacenes; Plasmids; Sequence Analysis, DNA; Streptomyces

2002
Nuclear transcription factor GATA-1 is activated during aclacinomycin-induced erythroid differentiation.
    Biology of the cell, 2002, Volume: 94, Issue:4-5

    Topics: Aclarubicin; Adjuvants, Immunologic; Antibody Specificity; Cell Compartmentation; Cell Nucleus; Cell Transformation, Neoplastic; DNA-Binding Proteins; Dose-Response Relationship, Drug; Erythrocytes; Erythroid Precursor Cells; Erythroid-Specific DNA-Binding Factors; Erythropoiesis; GATA1 Transcription Factor; Gene Expression Regulation, Leukemic; Hemoglobins; Humans; K562 Cells; Leukemia; Microscopy, Confocal; Phosphoric Monoester Hydrolases; Phosphorylation; Transcription Factors

2002
Engineering anthracycline biosynthesis toward angucyclines.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:4

    Topics: Aclarubicin; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Genetic Engineering; Multigene Family; Nogalamycin; Streptomyces

2003
Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
    The Journal of biological chemistry, 2003, Oct-03, Volume: 278, Issue:40

    Topics: Aclarubicin; Amino Acid Motifs; Amino Acid Sequence; Anthracyclines; Binding Sites; Carboxylic Ester Hydrolases; Catalysis; Crystallography, X-Ray; Electrons; Glycine; Hydrogen Bonding; Methionine; Models, Chemical; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Streptomyces

2003
[Study on the relationship between the inhibitors of apoptosis proteins and the apoptosis of myelodysplastic syndrome cell line cells induced by aclacinomycin in vitro].
    Zhongguo shi yan xue ye xue za zhi, 2004, Volume: 12, Issue:5

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Apoptosis; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Myelodysplastic Syndromes; Proteins; RNA, Messenger; Time Factors; Ubiquitin-Protein Ligases

2004
High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells.
    World journal of gastroenterology, 2005, Feb-21, Volume: 11, Issue:7

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; Hepatocytes; Humans; Lipoproteins, HDL; Liver Neoplasms

2005
[Sensitivity of survivin-positive primary leukemia cells to chemotherapy].
    Zhongguo shi yan xue ye xue za zhi, 2005, Volume: 13, Issue:2

    Topics: Aclarubicin; Acute Disease; Adolescent; Adult; Antineoplastic Agents; Cell Survival; Cytarabine; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Leukemia; Male; Microtubule-Associated Proteins; Middle Aged; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survivin; Tumor Cells, Cultured

2005
Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
    Journal of molecular biology, 2006, Mar-17, Volume: 357, Issue:1

    Topics: Aclarubicin; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Catalysis; Crystallography, X-Ray; Isomerases; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Nogalamycin; Protein Binding; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Recombinant Fusion Proteins; Streptomyces; Substrate Specificity

2006
[Studies on aclacinomycin spectral characters and the interaction between aclacinomycin and DNA by spectroscopic method].
    Guang pu xue yu guang pu fen xi = Guang pu, 2006, Volume: 26, Issue:9

    Topics: Aclarubicin; Animals; Cattle; DNA; Ethidium; Fluorescence; Hydrogen-Ion Concentration; Molecular Structure; Spectrometry, Fluorescence

2006
Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.
    Acta crystallographica. Section D, Biological crystallography, 2007, Volume: 63, Issue:Pt 2

    Topics: Aclarubicin; Bacterial Proteins; Crystallography; Molecular Structure; Oxidoreductases; Protein Conformation; Streptomyces

2007
Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Apr-10, Volume: 104, Issue:15

    Topics: Aclarubicin; Amino Acid Sequence; Catalysis; Computational Biology; Crystallography; Escherichia coli; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Molecular Structure; Monosaccharides; Mutagenesis, Site-Directed; Protein Conformation; Streptomyces

2007
The inhibitory effect of the proinflammatory cytokine TNFalpha on erythroid differentiation involves erythroid transcription factor modulation.
    International journal of oncology, 2009, Volume: 34, Issue:3

    Topics: Aclarubicin; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Doxorubicin; Erythroid Cells; GATA1 Transcription Factor; Hemin; Hemoglobins; Humans; K562 Cells; Nuclear Proteins; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha

2009
Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes.
    Molecular immunology, 2009, Volume: 47, Issue:2-3

    Topics: Aclarubicin; Animals; Biocatalysis; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; DNA Helicases; Inflammation; Interleukin-6; Kinetics; Mice; Nuclear Proteins; Nucleosomes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Transcription Factors; Vanadates

2009
Selected drugs with reported secondary cell-differentiating capacity prime latent HIV-1 infection for reactivation.
    Journal of virology, 2012, Volume: 86, Issue:17

    Topics: Aclarubicin; Anti-HIV Agents; Cell Differentiation; Cell Line; Dactinomycin; Drug Evaluation, Preclinical; HIV Infections; HIV-1; Humans; T-Lymphocytes; Virus Activation; Virus Latency

2012
CHAG priming regimen containing of cytarabine, aclacinomycin homoharringtonine and G-CSF for relapsed refractory acute myelogenous leukemia: a modified combination chemotherapeutic combination.
    Leukemia & lymphoma, 2013, Volume: 54, Issue:10

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Granulocyte Colony-Stimulating Factor; Harringtonines; Homoharringtonine; Humans; Leukemia, Myeloid, Acute; Treatment Outcome

2013
Redox-regulated pathway of tyrosine phosphorylation underlies NF-κB induction by an atypical pathway independent of the 26S proteasome.
    Biomolecules, 2015, Feb-09, Volume: 5, Issue:1

    Topics: Aclarubicin; Animals; Cell Line; Enzyme Activation; Humans; I-kappa B Kinase; Mice; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Signal Transduction; src-Family Kinases; Tyrosine; Vanadates

2015
Low-dose arsenic trioxide combined with aclacinomycin A synergistically enhances the cytotoxic effect on human acute myelogenous leukemia cell lines by induction of apoptosis.
    Leukemia & lymphoma, 2015, Volume: 56, Issue:11

    Topics: Aclarubicin; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Oxides

2015
[Cohort Study on GHA and New Combined Priming Chemotherapeutic Regimens in Treatment of Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome].
    Zhongguo shi yan xue ye xue za zhi, 2015, Volume: 23, Issue:2

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; B7-1 Antigen; Cohort Studies; Cytarabine; Doxorubicin; Granulocyte Colony-Stimulating Factor; Granulocytes; Harringtonines; Homoharringtonine; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Recurrence; Thrombocytopenia

2015
[Clinical Efficacy of Decitabine Combined with CAG Regimen for Myelodysplastic Syndrome-RAEB and Refractory Acute Myeloid Leukemia].
    Zhongguo shi yan xue ye xue za zhi, 2015, Volume: 23, Issue:4

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cytarabine; Decitabine; Granulocyte Colony-Stimulating Factor; Humans; Karyotype; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Pancytopenia; Recurrence; Remission Induction; Retrospective Studies; Survival Rate; Treatment Outcome

2015
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.
    Immunity, 2015, Sep-15, Volume: 43, Issue:3

    Topics: Aclarubicin; Animals; Cells, Cultured; Cytosol; Embryo, Mammalian; Exodeoxyribonucleases; Fibroblasts; Frameshift Mutation; HEK293 Cells; HeLa Cells; Hexosyltransferases; Humans; Immunity, Innate; Immunoblotting; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Phosphoproteins; Polysaccharides; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference

2015
[Efficacy of HAA regimen in the treatment of 64 patients with refractory/relapsed acute myeloid leukemia].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2016, Volume: 37, Issue:2

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Harringtonines; Homoharringtonine; Humans; Leukemia, Myeloid, Acute; Recurrence; Remission Induction; Retrospective Studies; Salvage Therapy; Survival Rate

2016
Decitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone.
    Journal of cancer research and clinical oncology, 2017, Volume: 143, Issue:5

    Topics: Aclarubicin; Adult; Anemia, Refractory, with Excess of Blasts; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cytarabine; Decitabine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Idarubicin; Karyotype; Male; Middle Aged; Mutation; Retrospective Studies

2017
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.
    Journal of autoimmunity, 2017, Volume: 81

    Topics: Aclarubicin; Amino Acid Substitution; Animals; Apoptosis; Autoantibodies; Autoimmunity; B-Lymphocytes; Enzyme Activation; Exodeoxyribonucleases; Frameshift Mutation; Gene Expression; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Mice; Mice, Transgenic; Phenotype; Phosphoproteins; Retina; Thymocytes; Transcriptome

2017
A retrospective study of the correlation of in vitro chemosensitivity using ATP-TCA with patient clinical outcomes in acute myeloid leukemia.
    Cancer chemotherapy and pharmacology, 2020, Volume: 85, Issue:3

    Topics: Aclarubicin; Adult; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Decitabine; Female; Humans; Idarubicin; Induction Chemotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Prognosis; Remission Induction; Retrospective Studies; Young Adult

2020
Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity.
    Organic letters, 2020, 01-03, Volume: 22, Issue:1

    Topics: Aclarubicin; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Polyketide Synthases; Streptomyces

2020
Relapsed/refractory early T-cell precursor acute lymphoblastic leukemia was salvaged by venetoclax plus HAG regimen.
    Annals of hematology, 2020, Volume: 99, Issue:2

    Topics: Aclarubicin; Adult; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Combined Modality Therapy; Cytarabine; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Homoharringtonine; Humans; Male; Mutation; Neoplasm Proteins; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Remission Induction; Salvage Therapy; Sulfonamides

2020
CAG (cytarabine, aclarubicin and granulocyte colony-stimulating factor) regimen for core binding factor acute myeloid leukaemia with measurable residual disease.
    Annals of hematology, 2023, Volume: 102, Issue:7

    Topics: Aclarubicin; Antineoplastic Combined Chemotherapy Protocols; Core Binding Factors; Cytarabine; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myeloid, Acute; Neoplasm Recurrence, Local; Neutropenia; Retrospective Studies; Treatment Outcome

2023
Aclarubicin stimulates RNA polymerase II elongation at closely spaced divergent promoters.
    Science advances, 2023, 06-16, Volume: 9, Issue:24

    Topics: Aclarubicin; Animals; Anthracyclines; Chromatin; Drosophila; Nucleosomes; Polyketides; RNA Polymerase II

2023