acid-phosphatase has been researched along with tyrosyl-isoleucyl-glycyl-seryl-arginine* in 1 studies
1 other study(ies) available for acid-phosphatase and tyrosyl-isoleucyl-glycyl-seryl-arginine
| Article | Year |
|---|---|
Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis.
Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis. Topics: Acid Phosphatase; Animals; Blood Vessels; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Giant Cells; Isoenzymes; Laminin; Mice; Oligopeptides; Osteoclasts; Osteogenesis; Rats; Rats, Sprague-Dawley; Tartrate-Resistant Acid Phosphatase; Tibia | 1998 |