acid-phosphatase and dienogest

acid-phosphatase has been researched along with dienogest* in 2 studies

Other Studies

2 other study(ies) available for acid-phosphatase and dienogest

Article	Year
Contraceptive potentiality of STS-557--a feasibility study in male bonnet monkey (Macaca radiata). Contraception, 1990, Volume: 41, Issue:6 STS-557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9(10)-diene-3-one) was administered (i.m.) to two groups (4 in each group) of adult male bonnet monkeys at a daily dose of 10 mg/monkey for 12 weeks (first group) and 5 mg/monkey for 14 weeks (second group). Treatment with the 10 mg dose resulted in a significant decline in the count, motility, acrosin and hyaluronidase activities and the fertilizing ability (zona-free hamster egg penetration assay) of spermatozoa by the 6th week of initiation of treatment. The circulating level of STS-557 was low after one week and increased from the 2nd week of treatment when the serum level of testosterone was significantly reduced. Complete recovery was observed by the 11th week after withdrawal of treatment. The treatment with the 5 mg dose had minor and inconsistent effect on the motility, hyaluronidase and acrosin activity, and the fertilizing ability of spermatozoa in addition to the blood level of testosterone. STS-557 may have the potentiality to be used as a chemical contraceptive in the male but compensation for the reduced level of blood testosterone may be necessary. Topics: Acid Phosphatase; Acrosin; Animals; Contraceptives, Oral; Dose-Response Relationship, Drug; Female; Fertility; Fructose; Glycerylphosphorylcholine; Hyaluronoglucosaminidase; Injections, Intramuscular; Male; Nandrolone; Progestins; Rabbits; Semen; Sperm Count; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa; Testosterone	1990
Effects of STS 557 on semen and sperm functions in bonnet monkey (Macaca radiata)--a preliminary report. Contraception, 1988, Volume: 37, Issue:6 Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm motility was reduced from the 3rd week of treatment. Complete recovery was observed by the 14th week after withdrawal of treatment. STS 557 may have the potentiality to be used as a chemical contraceptive in the male. Topics: Acid Phosphatase; Animals; Contraceptive Agents, Male; Macaca radiata; Male; Nandrolone; Semen; Sperm Motility; Spermatozoa; Testosterone	1988

Article

Year

Contraceptive potentiality of STS-557--a feasibility study in male bonnet monkey (Macaca radiata).

Contraception, 1990, Volume: 41, Issue:6

STS-557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9(10)-diene-3-one) was administered (i.m.) to two groups (4 in each group) of adult male bonnet monkeys at a daily dose of 10 mg/monkey for 12 weeks (first group) and 5 mg/monkey for 14 weeks (second group). Treatment with the 10 mg dose resulted in a significant decline in the count, motility, acrosin and hyaluronidase activities and the fertilizing ability (zona-free hamster egg penetration assay) of spermatozoa by the 6th week of initiation of treatment. The circulating level of STS-557 was low after one week and increased from the 2nd week of treatment when the serum level of testosterone was significantly reduced. Complete recovery was observed by the 11th week after withdrawal of treatment. The treatment with the 5 mg dose had minor and inconsistent effect on the motility, hyaluronidase and acrosin activity, and the fertilizing ability of spermatozoa in addition to the blood level of testosterone. STS-557 may have the potentiality to be used as a chemical contraceptive in the male but compensation for the reduced level of blood testosterone may be necessary.

Topics: Acid Phosphatase; Acrosin; Animals; Contraceptives, Oral; Dose-Response Relationship, Drug; Female; Fertility; Fructose; Glycerylphosphorylcholine; Hyaluronoglucosaminidase; Injections, Intramuscular; Male; Nandrolone; Progestins; Rabbits; Semen; Sperm Count; Sperm Motility; Sperm-Ovum Interactions; Spermatozoa; Testosterone

1990

Effects of STS 557 on semen and sperm functions in bonnet monkey (Macaca radiata)--a preliminary report.

Contraception, 1988, Volume: 37, Issue:6

Intramuscular administration of STS 557 (17 alpha C-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one) at a daily dose of 12 mg/monkey for 8 weeks induced severe oligospermia to complete azoospermia by the 9th week of initiation of treatment with concomitant decrease in the serum level of testosterone. The sperm motility was reduced from the 3rd week of treatment. Complete recovery was observed by the 14th week after withdrawal of treatment. STS 557 may have the potentiality to be used as a chemical contraceptive in the male.

Topics: Acid Phosphatase; Animals; Contraceptive Agents, Male; Macaca radiata; Male; Nandrolone; Semen; Sperm Motility; Spermatozoa; Testosterone

1988