Page last updated: 2024-09-02

acetylleucyl-leucyl-norleucinal and ebselen

acetylleucyl-leucyl-norleucinal has been researched along with ebselen in 4 studies

Compound Research Comparison

Studies
(acetylleucyl-leucyl-norleucinal)
Trials
(acetylleucyl-leucyl-norleucinal)
Recent Studies (post-2010)
(acetylleucyl-leucyl-norleucinal)
Studies
(ebselen)
Trials
(ebselen)
Recent Studies (post-2010) (ebselen)
3210538399366

Protein Interaction Comparison

ProteinTaxonomyacetylleucyl-leucyl-norleucinal (IC50)ebselen (IC50)
RNA polymerase beta subunit (EC 2.7.7.6), partialEscherichia coli11.6872
Arrestin, beta 1Homo sapiens (human)1.524
MPI proteinHomo sapiens (human)0.19
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium berghei15.0867
TPA: protein transporter TIM10Saccharomyces cerevisiae S288C5.29
TPA: protein transporter TIM23Saccharomyces cerevisiae S288C0.88
hexokinaseTrypanosoma brucei brucei TREU9270.9009
Spike glycoproteinBetacoronavirus England 10.67
Replicase polyprotein 1abBetacoronavirus England 10.67
neutrophil cytosol factor 1Homo sapiens (human)0.39
phosphomannomutase 2Homo sapiens (human)0.672
perilipin-5Homo sapiens (human)1.101
glucose-6-phosphate 1-dehydrogenase isoform bHomo sapiens (human)13.2
phosphoethanolamine/phosphocholine phosphatase isoform 1Homo sapiens (human)0.111
perilipin-1Homo sapiens (human)3.41
eukaryotic translation initiation factor 4 gamma 1 isoform 4Homo sapiens (human)1.15
eukaryotic translation initiation factor 4E isoform 1Mus musculus (house mouse)1.15
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)2.2555
Sulfhydryl oxidase 1Homo sapiens (human)5.4
Transmembrane protease serine 2Homo sapiens (human)0.67
Prostaglandin G/H synthase 1 Bos taurus (cattle)2.1
Gamma-butyrobetaine dioxygenaseHomo sapiens (human)0.742
Bile salt export pumpHomo sapiens (human)10
Procathepsin LHomo sapiens (human)0.67
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus0.67
Replicase polyprotein 1abHuman coronavirus 229E0.67
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus0.62
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 20.7928
Macrophage migration inhibitory factorHomo sapiens (human)2.4
Insulin-degrading enzymeHomo sapiens (human)0.028
Urease subunit alphaHelicobacter pylori 266953.745
Toxin BClostridioides difficile0.0172
Caspase-1Homo sapiens (human)4.04
Bifunctional epoxide hydrolase 2Homo sapiens (human)0.7575
Methionine aminopeptidase 2Homo sapiens (human)2.43
Spike glycoproteinSevere acute respiratory syndrome-related coronavirus0.67
Urease subunit betaHelicobacter pylori 266953.745
UDP-glucose 4-epimeraseHomo sapiens (human)0.014
Structural capsid protein Human immunodeficiency virus 10.0467
Histone-lysine N-methyltransferase EHMT2Homo sapiens (human)0.4
Angiotensin-converting enzyme 2 Homo sapiens (human)0.67
Histone-lysine N-methyltransferase EHMT1Homo sapiens (human)0.73
Histone deacetylase 6Homo sapiens (human)4.05
Histone deacetylase 9Homo sapiens (human)3.7
Histone deacetylase 5Homo sapiens (human)3.4
large T antigenBetapolyomavirus macacae13.91

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's4 (100.00)2.80

Authors

AuthorsStudies
Amin, SA; Banerjee, S; Gayen, S; Ghosh, K; Jha, T1
Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Basier, C; Beale, R; Bineva-Todd, G; Canal, B; Curran, JF; Deegan, T; Diffley, JFX; Fujisawa, R; Howell, M; Joshi, D; Labib, K; Lim, CT; Milligan, JC; Nagaraj, H; O'Reilly, N; Papageorgiou, G; Soudy, C; Tan, KW; Ulferts, R; Weissmann, F; Wu, M; Zeisner, TU1

Reviews

1 review(s) available for acetylleucyl-leucyl-norleucinal and ebselen

ArticleYear
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors.
    Bioorganic & medicinal chemistry, 2021, 01-01, Volume: 29

    Topics: Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Cysteine Proteinase Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Molecular Docking Simulation; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; SARS-CoV-2

2021

Other Studies

3 other study(ies) available for acetylleucyl-leucyl-norleucinal and ebselen

ArticleYear
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
    Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23

    Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors

2021
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
    The Biochemical journal, 2021, 07-16, Volume: 478, Issue:13

    Topics: Amino Acid Chloromethyl Ketones; Animals; Antiviral Agents; Azoles; Chlorocebus aethiops; Coronavirus 3C Proteases; Drug Evaluation, Preclinical; Enzyme Assays; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Isoindoles; Leupeptins; Organoselenium Compounds; Peptidomimetics; Reproducibility of Results; RNA-Binding Proteins; SARS-CoV-2; Small Molecule Libraries; Vero Cells; Viral Nonstructural Proteins

2021