Page last updated: 2024-09-02

acetylleucyl-leucyl-norleucinal and cycloheximide

acetylleucyl-leucyl-norleucinal has been researched along with cycloheximide in 12 studies

Compound Research Comparison

Studies
(acetylleucyl-leucyl-norleucinal)
Trials
(acetylleucyl-leucyl-norleucinal)
Recent Studies (post-2010)
(acetylleucyl-leucyl-norleucinal)
Studies
(cycloheximide)
Trials
(cycloheximide)
Recent Studies (post-2010) (cycloheximide)
32105319,1096861

Protein Interaction Comparison

ProteinTaxonomyacetylleucyl-leucyl-norleucinal (IC50)cycloheximide (IC50)
COUP transcription factor 2 isoform aHomo sapiens (human)1.315
Glucose transporterLeishmania mexicana0.242
Hexose transporter 1 Plasmodium falciparum (malaria parasite P. falciparum)0.31
Solute carrier family 2, facilitated glucose transporter member 1Homo sapiens (human)0.228
Eukaryotic initiation factor 4A-IHomo sapiens (human)0.139
Peptidyl-prolyl cis-trans isomerase FKBP1AHomo sapiens (human)3.6
Hypoxia-inducible factor 1-alphaHomo sapiens (human)0.036
Endothelial PAS domain-containing protein 1Homo sapiens (human)0.036

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (50.00)18.2507
2000's4 (33.33)29.6817
2010's1 (8.33)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Beatini, N; Maxfield, FR; Schissel, SL; Tabas, I; Zha, X1
Davis, EC; Mecham, RP1
Lu, Q; Mellgren, RL1
An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L1
Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T1
Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D1
Avner, R; Doolman, R; Harats, D; Ravid, T; Roitelman, J1
Peng, A; Sun, QY; Tan, X; Wang, Y; Wang, YC1
Barberà, A; Fernández-Novell, JM; Guinovart, JJ; Rodríguez-Gil, JE1
Harada, M; Omary, MB; Strnad, P; Toivola, DM1
Chang, PA; Chen, YY; Long, DX; Mou, XL; Qin, WZ1

Other Studies

12 other study(ies) available for acetylleucyl-leucyl-norleucinal and cycloheximide

ArticleYear
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells.
    Biochemistry, 1995, Aug-22, Volume: 34, Issue:33

    Topics: Animals; CHO Cells; Cholesterol Esters; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Esterification; Female; Hydroxycholesterols; Leucine; Leupeptins; Lipoproteins, VLDL; Macrophages, Peritoneal; Mice; Mice, Inbred ICR; Microscopy, Fluorescence; Sphingomyelin Phosphodiesterase

1995
Selective degradation of accumulated secretory proteins in the endoplasmic reticulum. A possible clearance pathway for abnormal tropoelastin.
    The Journal of biological chemistry, 1996, Feb-16, Volume: 271, Issue:7

    Topics: Ammonium Chloride; Animals; Blotting, Northern; Brefeldin A; Cattle; Cells, Cultured; Cycloheximide; Cyclopentanes; Endoplasmic Reticulum; Leucine; Leupeptins; Ligaments; Microscopy, Electron; Nocodazole; Organelles; Protein Synthesis Inhibitors; RNA, Messenger; Serine Proteinase Inhibitors; Transcription, Genetic; Tropoelastin

1996
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells.
    Archives of biochemistry and biophysics, 1996, Oct-01, Volume: 334, Issue:1

    Topics: Apoptosis; Calpain; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; Diazomethane; HL-60 Cells; Humans; Isocoumarins; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors

1996
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
    Oncogene, 1997, Jun-12, Volume: 14, Issue:23

    Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins

1997
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
    Oncogene, 1997, Aug-14, Volume: 15, Issue:7

    Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins

1997
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
    Oncogene, 1999, Jul-29, Volume: 18, Issue:30

    Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins

1999
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    The Journal of biological chemistry, 2000, Nov-17, Volume: 275, Issue:46

    Topics: Animals; beta-Galactosidase; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cholesterol; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Leupeptins; Lovastatin; Oligopeptides; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Tricarboxylic Acids; Ubiquitins

2000
Participation of the ubiquitin-proteasome pathway in rat oocyte activation.
    Zygote (Cambridge, England), 2005, Volume: 13, Issue:1

    Topics: Animals; Cell Nucleus Structures; Cells, Cultured; Colchicine; Cycloheximide; Cysteine Proteinase Inhibitors; Cytochalasin B; Female; Leupeptins; Meiosis; Oocytes; Parthenogenesis; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Ubiquitin

2005
Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism.
    Archives of biochemistry and biophysics, 2007, Jan-01, Volume: 457, Issue:1

    Topics: Animals; Calpain; Cations, Monovalent; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Glycogen Synthase; Glycogen Synthase Kinase 3; Hepatocytes; Leupeptins; Lithium Chloride; Liver Glycogen; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger

2007
Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.
    Experimental cell research, 2008, May-01, Volume: 314, Issue:8

    Topics: Apoptosis; Autophagy; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inclusion Bodies; Keratins; Leupeptins; Organelles; Proteasome Inhibitors; Protein Synthesis Inhibitors

2008
Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.
    Molecular biology reports, 2012, Volume: 39, Issue:6

    Topics: Adenine; Animals; Autophagy; Carboxylic Ester Hydrolases; Cycloheximide; Green Fluorescent Proteins; HEK293 Cells; Humans; Leupeptins; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Structure, Tertiary; Proteolysis; Recombinant Fusion Proteins

2012