acetylleucyl-leucyl-norleucinal has been researched along with calpain in 87 studies
| Studies (acetylleucyl-leucyl-norleucinal) | Trials (acetylleucyl-leucyl-norleucinal) | Recent Studies (post-2010) (acetylleucyl-leucyl-norleucinal) | Studies (calpain) | Trials (calpain) | Recent Studies (post-2010) (calpain) |
|---|---|---|---|---|---|
| 321 | 0 | 53 | 7,019 | 25 | 2,422 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 29 (33.33) | 18.2507 |
| 2000's | 34 (39.08) | 29.6817 |
| 2010's | 22 (25.29) | 24.3611 |
| 2020's | 2 (2.30) | 2.80 |
| Authors | Studies |
|---|---|
| Ceccarini, M; Di Stasi, AM; Gallo, V; Petrucci, TC | 1 |
| Beermann, ML; Nixon, RA; Shea, TB | 1 |
| Collins, T; Luscinskas, FW; Maniatis, T; Neish, AS; Palombella, VJ; Read, MA | 1 |
| Liu, L; Wang, M; Zimmerman, UJ | 1 |
| Lee, DB; Murray, EJ; Murray, SS; Tram, KK | 1 |
| Banik, N; Figueiredo-Pereira, ME; Wilk, S | 1 |
| Dixon, JL; Ginsberg, HN; Sakata, N; Wu, X | 1 |
| Lederkremer, GZ; Lodish, HF; Neumann, D; Yuk, MH | 1 |
| Cobb, RR; Felts, KA; Mackman, N; Parry, GC | 1 |
| Clifton, GL; Dixon, CE; Hayes, RL; Kampfl, A; Posmantur, R; Whitson, JS; Yang, K; Zhao, X | 1 |
| Assfalg-Machleidt, I; Machleidt, W; Moroder, L; Musiol, HJ; Rudolph-Böhner, S; Schaschke, N | 1 |
| Lu, Q; Mellgren, RL | 1 |
| Bartsch, T; Dietrich, C; Oesch, F; Schanz, F; Wieser, RJ | 1 |
| Bush, KT; Goldberg, AL; Nigam, SK | 1 |
| Harada, K; Yoshida, K | 1 |
| Baldin, V; Cans, C; Ducommun, B; Knibiehler, M | 1 |
| Anyane-Yeboa, K; Chan, SO; Chiu, FC; Ko, L; Runko, E | 1 |
| Brown, SB; Knepper-Nicolai, B; Savill, J | 1 |
| Di Sano, F; Oliverio, S; Piacentini, M; Spinedi, A | 1 |
| Imanaka, T; Kawabe, Y; Kodama, T; Sato, R; Takano, T | 1 |
| Lane, MD; Patel, YM | 2 |
| Hori, S; Nakagaki, I; Saido, TC; Tani, E; Tsubuki, S; Yamaura, I; Yokota, M | 1 |
| Parker, EM; Song, L; Zhang, L | 1 |
| Choi, YH; Henkart, PA; Hwang, SG; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, PM; Takano, E; Trepel, JB; Wu, ML | 1 |
| Buku, A; Efthimiopoulos, S; Figueiredo-Pereira, ME; Ghiso, J; Mehta, P; Robakis, NK; Tezapsidis, N | 1 |
| Asano, M; Kunimatsu, M; Manabe, T; Mishima, A; Saito, T; Sasaki, M; Ukai, T; Yamamoto, S | 1 |
| Droin, N; Eymin, B; Haugg, M; Munsch, B; Solary, E; Sordet, O; Van de Craen, M; Vandenabeele, P | 1 |
| Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N | 1 |
| An, WG; Blagosklonny, MV; Melillo, G; Neckers, LM; Nguyen, P; Trepel, JB | 1 |
| Imajoh-Ohmi, S; Kato, M; Kikuchi, H; Maki, M; Nonaka, T | 1 |
| Apostolopoulos, V; Gordon, S; Martinez-Pomares, L; McKenzie, IF; Pietersz, GA | 1 |
| An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB | 1 |
| Gautier, F; Grégoire, M; Harb, J; Irminger-Finger, I; Meflah, K | 1 |
| Enrich, C; Grewal, T; Jäckle, S; Pons, M; Rius, E; Schnitgerhans, T | 1 |
| Clevers, HC; Staal, FJ; Strous, GJ; van Noort, M | 1 |
| Burton, GR; Lyle, RE; May, JS; McGehee, RE; Prince, AM | 1 |
| Bryington, M; Cui, D; Datta, I; Fisher, AB; Hu, X; Liang, X; Zhang, X; Zuckerman, KS | 1 |
| Befus, AD; Forsythe, P | 1 |
| Akaike, A; Banno, Y; Fushimi, K; Kodama, H; Osawa, Y; Oshita, H; Shimizu, K | 1 |
| Banerjee, R; Francis, SE; Goldberg, DE | 1 |
| Chan, L; Chang, BH; Liao, W; Mancini, M | 1 |
| Harmon, AW; Patel, YM; Paul, DS; Winston, CP | 1 |
| Baadsgaard, O; Bang, B; Jäättelä, M; Skov, L | 1 |
| Brundage, K; Cuff, CF; Cunningham, CA; Kaetzel, CS; Pal, K | 1 |
| Cotter, TG; Donovan, M; Doonan, F | 1 |
| Akao, Y; Nozawa, Y; Ohguchi, K | 1 |
| Fujita, T; Inagi, R; Ingelfinger, JR; Kojima, I; Miyata, T; Nangaku, M; Ogawa, S; Ohse, T; Ota, T; Tanaka, T | 1 |
| Barberà, A; Fernández-Novell, JM; Guinovart, JJ; Rodríguez-Gil, JE | 1 |
| Chau, GY; Chau, YP; Chien, CL; Don, MJ; Kung, HN; Lu, KS | 1 |
| Inomata, M; Nakamura, M; Ohno, H; Shintani-Ishida, K; Uemura, K; Yoshida, K | 1 |
| Li, JJ; Xie, D | 1 |
| Brown, CS; Dean, WL | 1 |
| Chae, HJ; Chae, SU; Chae, SW; Ha, KC; Piao, CS | 1 |
| Li, XJ; Li, YH; Lin, YH; Shen, ZF; Tie, L; Wu, HL; Xu, Y; Yao, XH; Yu, HM | 1 |
| Aggeli, IK; Beis, I; Gaitanaki, C | 1 |
| Lee, S; Price, P; Roberts, S; Temple, S | 1 |
| Eletto, D; Passiatore, G; Peruzzi, F; Rom, S | 1 |
| Cai, H; Wang, T; Youn, JY | 1 |
| Endo, S; Kondo, M; Mourin, R; Nakazawa, T; Nishida, K; Saido, TC; Shimura, M; Yokokura, S | 1 |
| Minchin, RF; Mitchell, DJ | 1 |
| Choi, YY; Jung, SY; Kim, SY; Park, H; Park, KI; Soh, BY; Zheng, B | 1 |
| Hirotsune, S; Kengaku, M; Miyakawa, T; Mori, D; Sato, M; Sorimachi, H; Takao, K; Takitoh, T; Umeshima, H; Wynshaw-Boris, A; Yamada, M; Yoshida, Y | 1 |
| Ishiguro, S; Metoki, T; Mizukoshi, S; Nakazawa, M; Ozaki, T; Sato, K | 1 |
| Abrenica, B; Cook, T; Gilchrist, JS; Pierce, GN; Rashidkhani, B | 1 |
| Bastián, Y; Hernández-González, EO; Mújica, A; Roa-Espitia, AL | 1 |
| Cui, M; Kim, HS; Li, DY; Mallik, SK; Park, H; Song, HO | 1 |
| Ali, MA; Fan, X; Holt, A; Schulz, R; Stepanko, A | 1 |
| Broome, HJ; Hebert, MD; Velma, V | 1 |
| Baraban, SC; Bershteyn, M; Hirotsune, S; Sebe, JY; Wynshaw-Boris, A | 1 |
| Iskratsch, T; Lazar, AM; Lynch, CD; Sheetz, MP; Zhang, X | 1 |
| Duregotti, E; Montecucco, C; Rigoni, M; Tedesco, E | 1 |
| Ostergaard, HL; St-Pierre, J | 1 |
| Endo-Umeda, K; Imai, T; Ishige, K; Ito, Y; Kosuge, Y; Makishima, M; Miyagishi, H | 1 |
| Kiyoura, Y; Tamai, R | 1 |
| Burukoğlu, D; Kanbak, G; Kartkaya, K; Oğlakçı, A; Ozer, MC | 1 |
| Bagnaresi, P; Budu, A; Carmona, AK; Cotrin, SS; Cunha, RL; Gazarini, ML; Gomes, MM; Juliano, L; Ventura, PD | 1 |
| Raghupathi, R; Sang, N; Saunders, A; Tanzi, RE; Wang, H; Zhang, C | 1 |
| Barker, PA; Danelon, V; Mascó, DH; Montroull, LE; Unsain, N | 1 |
| Lee, DG; Lee, DS; Lee, HS; Lee, SR; Park, J | 1 |
| Chen, D; Chen, S; Deng, HX; Hu, YJ; Huang, JF; Long, LL; Shang, L; Wang, M; Xiong, K; Yan, J | 1 |
| Campos, EC; Celes, MR; Figueiredo, MJ; Freitas, AC; Ramos, SG; Soave, DF; Tanowitz, HB | 1 |
| Chen, C; Feng, D; Wang, X; Ye, J; Yin, R; Zhang, S; Zhang, Z; Zhao, X; Zhou, G | 1 |
| Bai, XH; Keshavjee, S; Kim, H; Liu, M; Lu, C; Zamel, R | 1 |
| Ahmed, M; Hwang, JS; Kim, DR; Lai, TH; Nguyen, HQ; Pham, TM; Zada, S | 1 |
| Baburuna, Y; Krestinina, O; Sotnikova, L | 1 |
| Chai, E; Liu, J; Tang, F; Wang, Q; Wei, Y; Zhang, S | 1 |
87 other study(ies) available for acetylleucyl-leucyl-norleucinal and calpain
| Article | Year |
|---|---|
Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity.
Topics: Animals; Blotting, Northern; Calcium; Calcium Channels; Calpain; Carrier Proteins; Cattle; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Kainic Acid; Leupeptins; Microfilament Proteins; N-Methylaspartate; Neurons; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Time Factors | 1991 |
Multiple proteases regulate neurite outgrowth in NB2a/dl neuroblastoma cells.
Topics: Animals; Axons; Blood; Calpain; Endopeptidases; Hirudins; Leupeptins; Neuroblastoma; Osmolar Concentration; Protease Inhibitors; Thrombin; Tumor Cells, Cultured | 1991 |
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression.
Topics: Base Sequence; Calpain; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cysteine Endopeptidases; E-Selectin; Endothelium, Vascular; Gene Expression; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-8; Leukocytes; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; NF-kappa B; Oligodeoxyribonucleotides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; RNA, Messenger; Time Factors; Transcription Factor RelB; Transcription Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1995 |
Inhibition of secretion from isolated rat alveolar epithelial type II cells by the cell permeant calpain inhibitor II (N-acetyl-leucyl-leucyl-methioninal).
Topics: Amino Acid Sequence; Animals; Calcium; Calpain; Cell Membrane Permeability; Epithelial Cells; Epithelium; In Vitro Techniques; Leupeptins; Molecular Sequence Data; Oligopeptides; Phosphatidylcholines; Protease Inhibitors; Pulmonary Alveoli; Rats | 1995 |
Parathyroid hormone-induced retraction of MC3T3-E1 osteoblastic cells is attenuated by the calpain inhibitor N-Ac-Leu-Leu-norleucinal.
Topics: Animals; Calpain; Cell Adhesion; Cell Size; Cells, Cultured; Glycoproteins; Leupeptins; Mice; Osteoblasts; Parathyroid Hormone | 1995 |
Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.
Topics: Amino Acid Sequence; Animals; Calpain; Cattle; Cysteine Endopeptidases; Dipeptides; Kinetics; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Pituitary Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Substrate Specificity | 1994 |
Proteolysis and lipid-facilitated translocation are distinct but competitive processes that regulate secretion of apolipoprotein B in Hep G2 cells.
Topics: Apolipoproteins B; Biological Transport; Calpain; Humans; In Vitro Techniques; Leupeptins; Liver; Oleic Acid; Oleic Acids; Protein Processing, Post-Translational; Secretory Rate; Tumor Cells, Cultured | 1993 |
Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms.
Topics: 3T3 Cells; Animals; Asialoglycoprotein Receptor; Asialoglycoproteins; Calpain; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Hydrolysis; Leupeptins; Mice; Receptors, Cell Surface; Receptors, Erythropoietin | 1996 |
Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-kappa B.
Topics: Base Sequence; Biological Transport; Calpain; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Endothelium, Vascular; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; NF-kappa B; Plasminogen Activator Inhibitor 1; Protease Inhibitors; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; RNA, Messenger; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Transfection; Vascular Cell Adhesion Molecule-1 | 1996 |
Calpain inhibitors protect against depolarization-induced neurofilament protein loss of septo-hippocampal neurons in culture.
Topics: Animals; Calcium Chloride; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Hippocampus; Leupeptins; Membrane Potentials; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; Potassium Chloride; Rats; Septum Pellucidum; Spectrin | 1996 |
Cyclodextrins as templates for the presentation of protease inhibitors.
Topics: beta-Cyclodextrins; Calpain; Carbohydrate Sequence; Circular Dichroism; Cyclodextrins; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Molecular Sequence Data | 1996 |
Calpain inhibitors and serine protease inhibitors can produce apoptosis in HL-60 cells.
Topics: Apoptosis; Calpain; Coumarins; Cycloheximide; Cysteine Proteinase Inhibitors; Diazomethane; HL-60 Cells; Humans; Isocoumarins; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Serine Proteinase Inhibitors | 1996 |
p53-dependent cell cycle arrest induced by N-acetyl-L-leucinyl-L-leucinyl-L-norleucinal in platelet-derived growth factor-stimulated human fibroblasts.
Topics: Calpain; Cathepsins; Cell Cycle; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Leupeptins; Lung; Multienzyme Complexes; Platelet-Derived Growth Factor; Proteasome Endopeptidase Complex; Tumor Suppressor Protein p53 | 1996 |
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
Topics: Acetylcysteine; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Endoplasmic Reticulum; Fungal Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; RNA, Messenger | 1997 |
Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion.
Topics: Animals; Ankyrins; Brain; Calpain; Cell Fractionation; Cysteine Proteinase Inhibitors; Erythrocytes; In Vitro Techniques; Leupeptins; Male; Molecular Weight; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation.
Topics: Calpain; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cyclin A; Cysteine Endopeptidases; HeLa Cells; Humans; Leupeptins; Multienzyme Complexes; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Threonine; Tyrosine | 1997 |
Calcium ionophore-induced degradation of neurofilament and cell death in MSN neuroblastoma cells.
Topics: Calcimycin; Calpain; Carrier Proteins; Cell Death; HSC70 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Intermediate Filament Proteins; Leupeptins; Nerve Tissue Proteins; Neuroblastoma; Neurofibrils; Oligopeptides; Tumor Cells, Cultured | 1998 |
Constitutive apoptosis in human neutrophils requires synergy between calpains and the proteasome downstream of caspases.
Topics: Actinin; Actins; Apoptosis; Calpain; Caspases; Cell Communication; Cells, Cultured; Cellular Senescence; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dipeptides; Drug Synergism; Humans; Leupeptins; Multienzyme Complexes; Neutrophils; Phosphoproteins; Proteasome Endopeptidase Complex | 1998 |
Calpain involvement in calphostin C-induced apoptosis.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Naphthalenes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; U937 Cells; Ubiquitins | 1998 |
Characterization of two Chinese hamster ovary cell lines expressing the COOH-terminal domains of sterol regulatory element-binding protein (SREBP)-1.
Topics: Animals; Calpain; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; CHO Cells; Cricetinae; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Gene Deletion; Hydroxymethylglutaryl-CoA Synthase; Leupeptins; Microsomes; Molecular Weight; Nuclear Proteins; Peptide Fragments; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Transfection | 1998 |
Role of calpain in adipocyte differentiation.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Adipocytes; Animals; Calcium-Binding Proteins; Calpain; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Dexamethasone; DNA-Binding Proteins; Insulin; Leupeptins; Mice; Nuclear Proteins; Recombinant Proteins; Transcription Factors; Transfection | 1999 |
Calpain inhibitor entrapped in liposome rescues ischemic neuronal damage.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Calpain; Carrier Proteins; Cell Death; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Carriers; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Gerbillinae; Hippocampus; Immunohistochemistry; Injections, Intravenous; Ischemic Attack, Transient; Leupeptins; Liposomes; Microfilament Proteins; Microscopy, Confocal; Neurons; Prosencephalon | 1999 |
Calpain inhibitor I increases beta-amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. Evidence that substrate availability limits beta-amyloid peptide production.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Calpain; Cell Line; Endopeptidases; Gene Expression Regulation; Humans; Leupeptins; Membrane Proteins; Molecular Sequence Data; Mutation; Peptide Fragments; Presenilin-1; Protease Inhibitors; Transfection | 1999 |
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Bucladesine; Calpain; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Dipeptides; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketones; Leupeptins; Lovastatin; Nuclear Proteins; Protein Processing, Post-Translational; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Tumor Cells, Cultured | 1999 |
Distinct secretases, a cysteine protease and a serine protease, generate the C termini of amyloid beta-proteins Abeta1-40 and Abeta1-42, respectively.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Calpain; CHO Cells; Cricetinae; Cysteine Endopeptidases; Dipeptides; Endopeptidases; Enzyme Inhibitors; Leupeptins; Peptide Fragments; Serine Endopeptidases | 1999 |
Protective effects of calpain inhibitor for prolonged hypothermic cardiac preservation.
Topics: Adenosine; Allopurinol; Animals; Antibodies; Calpain; Enzyme Precursors; Glutathione; Heart; Heart Transplantation; Hypothermia, Induced; Insulin; Leupeptins; Male; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Wistar; Time Factors | 1999 |
Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Base Sequence; Calpain; Caspase 3; Caspase 6; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Etoposide; Humans; Leukemia; Leupeptins; Microtubule-Associated Proteins; Molecular Sequence Data; Mutation; Nucleic Acid Synthesis Inhibitors; Oligopeptides; Protein Serine-Threonine Kinases; Thimerosal; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 1999 |
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins | 1999 |
Regulation of BRCA1 by protein degradation.
Topics: BRCA1 Protein; Calpain; Carrier Proteins; Cell Nucleus; Cysteine Endopeptidases; Dactinomycin; Down-Regulation; Endopeptidases; Exportin 1 Protein; Gene Expression Regulation; Half-Life; Humans; Hydrolysis; Karyopherins; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Tumor Cells, Cultured | 1999 |
Caspases cleave the amino-terminal calpain inhibitory unit of calpastatin during apoptosis in human Jurkat T cells.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; Aspartic Acid; Calcium-Binding Proteins; Calpain; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; fas Receptor; Humans; Jurkat Cells; Leupeptins; Oligopeptides; Poly(ADP-ribose) Polymerases; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2000 |
Mitotic clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27.
Topics: 3T3 Cells; Adipocytes; Animals; Calpain; Cell Cycle Proteins; Cell Differentiation; Clone Cells; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Cytoplasm; Gene Expression Regulation; Genes, Immediate-Early; Kinetics; Leupeptins; Mice; Microtubule-Associated Proteins; Mitosis; Recombinant Proteins; Time Factors; Transfection; Triglycerides; Tumor Suppressor Proteins | 2000 |
Aldehyde-mannan antigen complexes target the MHC class I antigen-presentation pathway.
Topics: Aldehydes; Animals; Antigen Presentation; Calpain; Cathepsin B; Cells, Cultured; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endosomes; Histocompatibility Antigens Class I; Humans; Lectins, C-Type; Leupeptins; Lysosomes; Macrophages, Peritoneal; Mannans; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mucin-1; Multienzyme Complexes; Oxidation-Reduction; Peptide Fragments; Proteasome Endopeptidase Complex; Receptors, Cell Surface; Schiff Bases | 2000 |
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Apoptosis; Autoantigens; Blotting, Western; BRCA1 Protein; Breast Neoplasms; Calpain; Carrier Proteins; Cell Cycle; Cell Fractionation; Cloning, Molecular; Colonic Neoplasms; Cysteine Proteinase Inhibitors; DNA, Complementary; Egtazic Acid; Enzyme Inhibitors; Gene Library; Humans; Leupeptins; Mammary Neoplasms, Animal; Mice; Molecular Sequence Data; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2000 |
Evidence for the Involvement of annexin 6 in the trafficking between the endocytic compartment and lysosomes.
Topics: Animals; Annexin A6; Calpain; Carbocyanines; Cell Compartmentation; CHO Cells; Cricetinae; Endocytosis; Fluorescent Antibody Technique; Fluorescent Dyes; Genetic Vectors; Iodine Radioisotopes; Leupeptins; Lipoproteins, LDL; Lysosomes; Protein Transport; Spectrin; Subcellular Fractions; Transport Vesicles | 2001 |
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin.
Topics: Animals; beta Catenin; Calpain; CHO Cells; Cricetinae; Cytoskeletal Proteins; DNA-Binding Proteins; Leupeptins; Lymphoid Enhancer-Binding Factor 1; Phosphorylation; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcription Factors; Transcription, Genetic; Wnt Proteins; Zebrafish Proteins | 2002 |
Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.
Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Nuclear Proteins; Peptide Hydrolases; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Retinoblastoma-Like Protein p130 | 2002 |
Ubiquitin/proteasome-dependent degradation of D-type cyclins is linked to tumor necrosis factor-induced cell cycle arrest.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Blotting, Western; Calpain; Caspase 3; Caspases; Cell Cycle; Cell Line; Cyclin D; Cyclin D3; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; G1 Phase; Humans; I-kappa B Proteins; Leupeptins; Multienzyme Complexes; NF-KappaB Inhibitor alpha; Peptide Hydrolases; Plasmids; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Biosynthesis; Ribonucleases; RNA; RNA, Messenger; Spectrometry, Fluorescence; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ubiquitin | 2002 |
Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion.
Topics: Calpain; Cell Adhesion; Cyclic GMP; Dipeptides; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Humans; Leupeptins; Mast Cells; Nitric Oxide; Nitric Oxide Donors; Peroxynitrous Acid; Protein Binding; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Tumor Cells, Cultured | 2003 |
Synergistic induction of apoptosis of rheumatoid arthritis synovial cells by H(2)O(2) and N-acetyl-leucyl-leucyl-norleucinal.
Topics: Apoptosis; Arthritis, Rheumatoid; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; Hydrogen Peroxide; Leupeptins; Synovial Membrane | 2003 |
Food vacuole plasmepsins are processed at a conserved site by an acidic convertase activity in Plasmodium falciparum.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Calpain; Cell-Free System; Endopeptidases; Hydrogen-Ion Concentration; Kinetics; Leupeptins; Molecular Sequence Data; Plasmodium falciparum; Protease Inhibitors; Protein Processing, Post-Translational; Protozoan Proteins; Vacuoles | 2003 |
Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells.
Topics: Apolipoprotein B-100; Apolipoproteins B; Biological Transport; Calpain; Carcinoma, Hepatocellular; Cell Compartmentation; Cysteine Endopeptidases; Cytosol; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Leupeptins; Microsomes, Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Ubiquitin | 2003 |
Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes.
Topics: Actin Cytoskeleton; Adipocytes; Animals; Biological Transport; Calpain; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Leupeptins; Monosaccharide Transport Proteins; Muscle Proteins; Phosphorylation; Protein Transport; Signal Transduction; Transport Vesicles | 2003 |
Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Calpain; Caspase Inhibitors; Cathepsins; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; HeLa Cells; Humans; Keratinocytes; Ketones; Leupeptins; Phospholipases A; Ultraviolet Rays | 2004 |
Regulation of polymeric immunoglobulin receptor expression by reovirus.
Topics: Calpain; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Intestinal Mucosa; Leupeptins; Mammalian orthoreovirus 3; Receptors, Polymeric Immunoglobulin; Ultraviolet Rays; Up-Regulation | 2005 |
Activation of multiple pathways during photoreceptor apoptosis in the rd mouse.
Topics: Animals; Apoptosis; Blotting, Western; Calcium; Calpain; Cathepsin D; Cell-Free System; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Immunoenzyme Techniques; In Situ Nick-End Labeling; Leupeptins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Organ Culture Techniques; Photoreceptor Cells, Vertebrate; Reactive Oxygen Species; Retinal Degeneration; Signal Transduction | 2005 |
Involvement of calpain in melanogenesis of mouse B16 melanoma cells.
Topics: alpha-MSH; Animals; Blotting, Western; Calcium-Binding Proteins; Calpain; Cell Differentiation; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Hormones; Indolequinones; Leupeptins; Melanins; Melanocytes; Melanoma, Experimental; Mice; Monophenol Monooxygenase; RNA, Messenger; Tumor Cells, Cultured | 2005 |
Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.
Topics: Acrylates; Animals; Apoptosis; Calpain; Caspase 12; Caspase 3; Caspase Inhibitors; Caspases; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Gene Expression Regulation; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Kidney Tubules, Proximal; Leupeptins; Molecular Chaperones; Oligopeptides; Proteins; Proteinuria; Rats; Serum Albumin, Bovine; Stress, Physiological | 2006 |
Lithium ions increase hepatic glycogen synthase stability through a proteasome-related mechanism.
Topics: Animals; Calpain; Cations, Monovalent; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Glycogen Synthase; Glycogen Synthase Kinase 3; Hepatocytes; Leupeptins; Lithium Chloride; Liver Glycogen; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2007 |
Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.
Topics: Angiogenesis Inhibitors; Apoptosis; Arginine; Calcium; Calpain; Caspases; Cell Line; Cell Survival; Chelating Agents; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Leupeptins; Membrane Potential, Mitochondrial; Naphthoquinones; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oligopeptides; Signal Transduction; Time Factors | 2007 |
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.
Topics: Acetylcysteine; Calpain; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cell Death; Cell Line, Tumor; Delta Catenin; Dipeptides; Humans; Ischemia; Leupeptins; Neuroblastoma; Phosphoproteins | 2007 |
Cleavage of focal adhesion kinase (FAK) is essential in adipocyte differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Blotting, Western; Calcimycin; Calpain; Cell Differentiation; Cell Nucleus; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Ionophores; Leupeptins; Mice; Microscopy, Confocal; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Signal Transduction; Time Factors | 2007 |
Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain.
Topics: Blood Platelets; Calcium; Calcium-Transporting ATPases; Calpain; Cell Membrane; Collagen; Dipeptides; Enzyme Activation; Humans; Leupeptins; Platelet Activation; Thrombin | 2007 |
Estrogen attenuates cardiac ischemia-reperfusion injury via inhibition of calpain-mediated bid cleavage.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Calpain; Caspase Inhibitors; Caspases; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Enzyme Activation; Estradiol; Female; Hydrogen Peroxide; Leupeptins; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Ovariectomy; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Severity of Illness Index | 2007 |
Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Dipeptides; Down-Regulation; Glucose; Half-Life; Hippocampus; Insulin; Leupeptins; Male; Nerve Tissue Proteins; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells.
Topics: alpha-Crystallin B Chain; Animals; Apoptosis; Calcium Signaling; Calpain; Caspase 3; Cell Line; Cell Nucleus; Cytochromes c; Egtazic Acid; Hydrogen Peroxide; Leupeptins; Myocytes, Cardiac; Oligopeptides; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Poly(ADP-ribose) Polymerases; Protein Transport; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Time Factors; Tubulin | 2008 |
Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein.
Topics: Acrylates; Calpain; Cells, Cultured; Dipeptides; Glycoproteins; Humans; Interleukin-1alpha; Leupeptins; Polymorphism, Genetic; RNA, Messenger | 2008 |
HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity.
Topics: Amino Acid Sequence; Animals; Calpain; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Intracellular Space; Leupeptins; Molecular Sequence Data; Neurons; Protein Processing, Post-Translational; Protein Stability; Protein Transport; Rats; Stem Cells; Subcellular Fractions; tat Gene Products, Human Immunodeficiency Virus | 2009 |
An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.
Topics: AMP-Activated Protein Kinases; Animals; Aorta; Calpain; Cattle; Cells, Cultured; Cytoskeletal Proteins; Dipeptides; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Hydrogen Peroxide; Leupeptins; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Interaction Mapping; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Vascular Endothelial Growth Factor A | 2009 |
Calpain-mediated degradation of G-substrate plays a critical role in retinal excitotoxicity for amacrine cells.
Topics: Amacrine Cells; Analysis of Variance; Animals; Blotting, Western; Calpain; Cell Death; Cysteine Proteinase Inhibitors; Dipeptides; Immunohistochemistry; In Situ Nick-End Labeling; Leupeptins; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Nerve Tissue Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Retina | 2009 |
Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Calpain; Cysteine Proteinase Inhibitors; Cytosol; Escherichia coli; Escherichia coli Proteins; Glutathione Transferase; Half-Life; HeLa Cells; Humans; Leupeptins; Molecular Sequence Data; NIMA-Interacting Peptidylprolyl Isomerase; Okadaic Acid; Peptidylprolyl Isomerase; Phosphorylation; Proline; Protein Binding; Recombinant Proteins; Serine; Sulfotransferases; Threonine; Transfection; Two-Hybrid System Techniques | 2009 |
Antimalarial effect of N-acetyl-L-Leucyl-L-leucyl-L-norleucinal by the inhibition of Plasmodium falciparum Calpain.
Topics: Animals; Antimalarials; Calpain; Drug Evaluation, Preclinical; Erythrocytes; HeLa Cells; Humans; Leupeptins; Parasitemia; Plasmodium falciparum; Protozoan Proteins; Schizonts; Trophozoites | 2009 |
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Calpain; Cell Movement; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dyneins; Embryo, Mammalian; Female; Fibroblasts; Gene Expression Regulation, Developmental; Leucine; Leupeptins; Lissencephaly; Mice; Mice, Knockout; Microtubule-Associated Proteins; Models, Neurological; Neurons; Phenotype; Pregnancy | 2009 |
Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration.
Topics: Acrylates; Animals; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; Cytosol; Electrophoresis, Polyacrylamide Gel; Immunoenzyme Techniques; In Situ Nick-End Labeling; Leupeptins; Mitochondria; Photoreceptor Cells, Vertebrate; Rats; Rats, Mutant Strains; Retinal Degeneration | 2010 |
Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusion.
Topics: Animals; Autolysis; Blotting, Western; Calpain; Cell Fractionation; Cytosol; Disease Models, Animal; Dogs; Electrophoresis, Polyacrylamide Gel; Intracellular Membranes; Leupeptins; Male; Muscle, Skeletal; Myocardial Reperfusion Injury; Myocardium; Oligopeptides; Rabbits; Rats; Rats, Sprague-Dawley | 2010 |
Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton.
Topics: Acrosome Reaction; Animals; Blotting, Western; Calcium-Binding Proteins; Calpain; Cytoskeleton; Dipeptides; Guinea Pigs; Leupeptins; Male; Microscopy, Electron; Spectrin; Sperm Capacitation; Spermatozoa | 2010 |
Synthesis and evaluation of peptidyl α,β-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors.
Topics: Antimalarials; Calpain; Cell Proliferation; Chromatography; Cysteine Proteinase Inhibitors; Flow Cytometry; HeLa Cells; Humans; Leupeptins; Magnetic Resonance Spectroscopy; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship | 2012 |
Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity.
Topics: Acrylates; Calpain; Catalysis; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Gelatin; Humans; Inhibitory Concentration 50; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Oligopeptides; Phenyl Ethers; Troponin I | 2012 |
Regulated specific proteolysis of the Cajal body marker protein coilin.
Topics: Calpain; Cell Cycle; Cell Nucleolus; Coiled Bodies; HeLa Cells; Humans; Leupeptins; Nuclear Proteins; Proteolysis | 2012 |
ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice.
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Animals; Calpain; Cysteine Proteinase Inhibitors; Excitatory Postsynaptic Potentials; Gene Expression; Heterozygote; Leupeptins; Lissencephaly; Mice; Mice, Mutant Strains; Microtubule-Associated Proteins; Miniature Postsynaptic Potentials; Mutation; Proteolysis; Pyramidal Cells; Spectrin | 2013 |
Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions.
Topics: Animals; Calpain; Cell Movement; Cells, Cultured; Contractile Proteins; Cysteine Proteinase Inhibitors; Cytoskeleton; Embryo, Mammalian; Fibroblasts; Filamins; Focal Adhesions; Immunohistochemistry; Leupeptins; Luminescent Proteins; Mice; Mice, Knockout; Microfilament Proteins; Microscopy, Fluorescence; Microtubules; Models, Biological; Myosin Type II; RNA Interference; Talin; Vimentin | 2013 |
Calpains participate in nerve terminal degeneration induced by spider and snake presynaptic neurotoxins.
Topics: Acrylates; Animals; Animals, Newborn; Calcium Signaling; Calpain; Cell Membrane Permeability; Cells, Cultured; Cytoskeleton; Dipeptides; Leupeptins; Nerve Degeneration; Neurofilament Proteins; Neurons; Neurotoxins; Phospholipases A2; Presynaptic Terminals; Rats; Rats, Wistar; Snake Venoms; Spectrin; Spider Venoms | 2013 |
A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation.
Topics: Animals; Blotting, Western; Calpain; Cell Adhesion; Cell Movement; Cell Shape; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytoskeleton; Focal Adhesion Kinase 1; Focal Adhesion Kinase 2; Leukocyte Common Antigens; Leupeptins; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Paxillin; Phosphorylation; Proteolysis; src-Family Kinases; Time-Lapse Imaging | 2013 |
Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain.
Topics: Animals; Apoptosis; Calcium-Binding Proteins; Calpain; Cell Survival; Cells, Cultured; Cysteine; Dipeptides; Endoplasmic Reticulum Stress; Hippocampus; Leupeptins; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Spectrin | 2014 |
Candida albicans and Candida parapsilosis rapidly up-regulate galectin-3 secretion by human gingival epithelial cells.
Topics: Actins; Blood Proteins; Calpain; Candida albicans; Cell Line; Chromones; Cytochalasin D; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Fibroblasts; Galectin 3; Galectins; Gingiva; Humans; Leupeptins; Morpholines; Phosphoinositide-3 Kinase Inhibitors | 2014 |
Protective effect of calpain inhibitor N-acetyl-L-leucyl-L-leucyl-L-norleucinal on acute alcohol consumption related cardiomyopathy.
Topics: Animals; Binge Drinking; Calpain; Cardiomyopathies; Caspase 3; Cathepsin B; Cathepsin L; Creatine Kinase, MB Form; Cysteine Proteinase Inhibitors; Cytochromes c; Disease Models, Animal; Humans; Immunohistochemistry; Leupeptins; Male; Myocardium; Nerve Tissue Proteins | 2014 |
Specific calpain activity evaluation in Plasmodium parasites.
Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Leupeptins; Male; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Plasmodium chabaudi; Plasmodium falciparum; Protozoan Proteins; Spectrometry, Fluorescence | 2015 |
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Calpain; Cathepsin L; Cattle; Cell Line, Tumor; Cells, Cultured; Humans; L-Lactate Dehydrogenase; Leupeptins; Peptide Fragments; Proteolysis; Rats; Ubiquitination | 2015 |
Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes.
Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Hippocampus; Leupeptins; Neurons; Protease Inhibitors; Proteolysis; Rats; Rats, Wistar; Receptor, trkB; Status Epilepticus | 2016 |
Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells.
Topics: Animals; Calcineurin; Calcium; Calcium Signaling; Calmodulin; Calpain; Cell Death; Cell Line; Cell Survival; Dynamins; Ferric Compounds; Hippocampus; Iron; Iron Overload; Leupeptins; Mice; Mitochondria; Neurons; Quaternary Ammonium Compounds; Sulfonamides | 2016 |
Inhibition of calpain on oxygen glucose deprivation-induced RGC-5 necroptosis.
Topics: Animals; Apoptosis Inducing Factor; Calpain; Gene Expression Regulation; Glucose; Humans; Leupeptins; Mice; Oxygen; Retinal Ganglion Cells; Retinal Necrosis Syndrome, Acute | 2016 |
Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition.
Topics: Actins; Animals; Calpain; Cardiomyopathies; Disease Models, Animal; Dystrophin; Gene Expression; Leupeptins; Male; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Myocardium; Myosins; Proteasome Endopeptidase Complex; Proteolysis; Sepsis; TOR Serine-Threonine Kinases; Ubiquitin | 2016 |
Sepia Ink Oligopeptide Induces Apoptosis of Lung Cancer Cells via Mitochondrial Pathway.
Topics: A549 Cells; Animals; Apoptosis; bcl-2-Associated X Protein; Calpain; Caspase 12; Caspase 8; Caspase 9; Cell Proliferation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; fas Receptor; Humans; Ink; Leupeptins; Lung Neoplasms; Mitochondria; Oligopeptides; Proline; Proto-Oncogene Proteins c-bcl-2; Sepia; Thiocarbamates; Transcription Factor CHOP | 2018 |
Ischemia-reperfusion induces death receptor-independent necroptosis via calpain-STAT3 activation in a lung transplant setting.
Topics: Apoptosis; Calpain; Cells, Cultured; Humans; Imidazoles; Indoles; Leupeptins; Lung Transplantation; Necrosis; Phosphorylation; Primary Graft Dysfunction; Receptor-Interacting Protein Serine-Threonine Kinases; Receptors, Death Domain; Reperfusion Injury; Signal Transduction; STAT3 Transcription Factor | 2018 |
Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions.
Topics: Animals; Apoptosis; Beclin-1; Calpain; Caspases; Cell Line; Cell Survival; Cellular Senescence; Glutamic Acid; HeLa Cells; Hippocampus; Humans; Leupeptins; Mice; Neurons; NIH 3T3 Cells; Oxidative Stress; Reactive Oxygen Species | 2019 |
Identification of Phosphorylated Calpain 3 in Rat Brain Mitochondria under mPTP Opening.
Topics: Animals; Apoptosis; Brain; Calcium; Calcium Signaling; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Isoenzymes; Leupeptins; Male; Mitochondria; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Molecular Weight; Muscle Proteins; Phosphorylation; Protein Transport; Rats | 2021 |
Calpain inhibitor prevents atherosclerosis in apolipoprotein E knockout mice by regulating mRNA expression of genes related to cholesterol uptake and efflux.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Aorta; Aortic Diseases; Atherosclerosis; ATP Binding Cassette Transporter 1; Calpain; Cholesterol; Cysteine Proteinase Inhibitors; Disease Models, Animal; Gene Expression Regulation; Leupeptins; Lipid Metabolism; Liver X Receptors; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mice, Knockout, ApoE; Plaque, Atherosclerotic; PPAR gamma; RNA, Messenger; Scavenger Receptors, Class A | 2022 |