acetylleucyl-leucyl-norleucinal has been researched along with benzyloxycarbonylleucyl-leucyl-leucine aldehyde in 36 studies
| Studies (acetylleucyl-leucyl-norleucinal) | Trials (acetylleucyl-leucyl-norleucinal) | Recent Studies (post-2010) (acetylleucyl-leucyl-norleucinal) | Studies (benzyloxycarbonylleucyl-leucyl-leucine aldehyde) | Trials (benzyloxycarbonylleucyl-leucyl-leucine aldehyde) | Recent Studies (post-2010) (benzyloxycarbonylleucyl-leucyl-leucine aldehyde) |
|---|---|---|---|---|---|
| 321 | 0 | 53 | 2,473 | 3 | 1,057 |
| Protein | Taxonomy | acetylleucyl-leucyl-norleucinal (IC50) | benzyloxycarbonylleucyl-leucyl-leucine aldehyde (IC50) |
|---|---|---|---|
| Proteasome subunit beta type-11 | Homo sapiens (human) | 1.9893 | |
| Calpain-9 | Homo sapiens (human) | 9.88 | |
| Proteasome subunit alpha type-7 | Homo sapiens (human) | 1.9893 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | 3.9 | |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | 3.8999 | |
| Aromatase | Homo sapiens (human) | 0.044 | |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | 0.5 | |
| Proteasome subunit beta type-1 | Homo sapiens (human) | 1.0853 | |
| Proteasome subunit alpha type-1 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-2 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-3 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-4 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-8 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-9 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha type-5 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-4 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-6 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-5 | Homo sapiens (human) | 0.6088 | |
| Proteasome subunit beta type-10 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-3 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-2 | Homo sapiens (human) | 2.0443 | |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit alpha-type 8 | Homo sapiens (human) | 1.9893 | |
| Proteasome subunit beta type-7 | Homo sapiens (human) | 1.9893 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (30.56) | 18.2507 |
| 2000's | 17 (47.22) | 29.6817 |
| 2010's | 4 (11.11) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Amin, SA; Banerjee, S; Gayen, S; Ghosh, K; Jha, T | 1 |
| Chen, J; Gao, K; Huang, F; Tepe, JJ; Wang, R; Wei, GW | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Collins, T; Luscinskas, FW; Maniatis, T; Neish, AS; Palombella, VJ; Read, MA | 1 |
| Goldberg, AL; Jensen, TJ; Loo, MA; Pind, S; Riordan, JR; Williams, DB | 1 |
| Goldberg, AL; Maniatis, T; Palombella, VJ; Rando, OJ | 1 |
| Goldberg, AL; Grimm, LM; Osborne, BA; Poirier, GG; Schwartz, LM | 1 |
| Bush, KT; Goldberg, AL; Nigam, SK | 1 |
| Goldberg, AL; Odessey, R; Tawa, NE | 1 |
| Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T | 1 |
| Harada, K; Yoshida, K | 1 |
| Gil, R; Miller, JR; Moon, RT; Seeling, JM; Virshup, DM; White, R | 1 |
| Dewhurst, S; Elliott, PR; Epstein, LG; Fine, SM; Gelbard, HA; Maggirwar, SB | 1 |
| Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N | 1 |
| McBride, AA; Penrose, KJ | 1 |
| Hamahata, K; Kubota, M; Lin, Y; Usami, I; Watanabe, K | 1 |
| Avner, R; Doolman, R; Harats, D; Ravid, T; Roitelman, J | 1 |
| Goldenberg, GJ; Lam, V; McPherson, JP; Salmena, L | 1 |
| Choi, YH | 1 |
| Chase, BI; Silverman, RH; Xiang, Y; Zhou, A; Zhou, Y | 1 |
| Cervello, M; D'Alessandro, N; Giannitrapani, L; La Rosa, M; Labbozzetta, M; Montalto, G; Notarbartolo, M; Poma, P | 1 |
| Chang, YC; Kwon, TK; Lim, JH; Park, JW; Park, YB | 1 |
| Kao, HY; Ko, SH; Li, X; Liu, Y; Song, S | 1 |
| Chen, DY; Fan, HY; Huo, LJ; Schatten, H; Sun, QY; Zhong, ZS | 1 |
| Baker, AH; Denby, L; Nicklin, SA | 1 |
| Londos, C; Sztalryd, C; Xu, G | 1 |
| Lubsen, NH; Marín-Vinader, L; Onnekink, C; Slingsby, C; van Genesen, ST | 1 |
| Dolcet, X; Encinas, M; Eritja, N; Llobet, D; Llombart-Cussac, A; Marti, RM; Matias-Guiu, X; Schoenenberger, JA; Sorolla, A; Yeramian, A | 1 |
| Li, XJ; Li, YH; Lin, YH; Shen, ZF; Tie, L; Wu, HL; Xu, Y; Yao, XH; Yu, HM | 1 |
| Chang, WH; Chen, TJ; Hsieh, M; Nukina, N; Tien, CL | 1 |
| Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM | 1 |
| Ann, EJ; Kim, MY; Kim, SM; Mo, JS; Park, HS; Yoon, JH | 1 |
| Chang, PA; Chen, YY; Long, DX; Mou, XL; Qin, WZ | 1 |
| Hajitou, A; O'Neill, K; Przystal, JM; Stoneham, CA; Syed, N; Umukoro, E; Yata, T | 1 |
| Fan, Y; You, G | 1 |
1 review(s) available for acetylleucyl-leucyl-norleucinal and benzyloxycarbonylleucyl-leucyl-leucine aldehyde
| Article | Year |
|---|---|
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors.
Topics: Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Cysteine Proteinase Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Molecular Docking Simulation; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; SARS-CoV-2 | 2021 |
35 other study(ies) available for acetylleucyl-leucyl-norleucinal and benzyloxycarbonylleucyl-leucyl-leucine aldehyde
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Perspectives on SARS-CoV-2 Main Protease Inhibitors.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Humans; Protease Inhibitors | 2021 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression.
Topics: Base Sequence; Calpain; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cysteine Endopeptidases; E-Selectin; Endothelium, Vascular; Gene Expression; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-8; Leukocytes; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; NF-kappa B; Oligodeoxyribonucleotides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; RNA, Messenger; Time Factors; Transcription Factor RelB; Transcription Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 1995 |
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.
Topics: Acetylcysteine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endopeptidases; Endoplasmic Reticulum; Humans; Leupeptins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ubiquitins | 1995 |
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Cells, Cultured; Cysteine Endopeptidases; DNA-Binding Proteins; Humans; I-kappa B Proteins; Leupeptins; Models, Biological; Molecular Sequence Data; Multienzyme Complexes; NF-kappa B; NF-kappa B p50 Subunit; NF-KappaB Inhibitor alpha; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Precursors; Protein Processing, Post-Translational; Ubiquitins | 1994 |
Proteasomes play an essential role in thymocyte apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; DNA Ligases; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes | 1996 |
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
Topics: Acetylcysteine; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Endoplasmic Reticulum; Fungal Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; RNA, Messenger | 1997 |
Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.
Topics: Animals; Atrophy; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diaphragm; Kinetics; Leupeptins; Male; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Rats, Inbred Strains | 1997 |
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Proteolysis of erythrocyte-type and brain-type ankyrins in rat heart after postischemic reperfusion.
Topics: Animals; Ankyrins; Brain; Calpain; Cell Fractionation; Cysteine Proteinase Inhibitors; Erythrocytes; In Vitro Techniques; Leupeptins; Male; Molecular Weight; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Down-Regulation; Genes, Reporter; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Leupeptins; Multienzyme Complexes; Mutation; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Phosphatase 2; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 1999 |
Proteasome blockers inhibit TNF-alpha release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia.
Topics: AIDS Dementia Complex; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Probes; Enzyme Activation; Fetus; Gene Expression; HIV-1; Humans; Leupeptins; Lipopolysaccharides; Macrophages; Microglia; Multienzyme Complexes; NF-kappa B; Phagocytosis; Proteasome Endopeptidase Complex; Tumor Necrosis Factor-alpha | 1999 |
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins | 1999 |
Proteasome-mediated degradation of the papillomavirus E2-TA protein is regulated by phosphorylation and can modulate viral genome copy number.
Topics: Alanine; Animals; Bovine papillomavirus 1; Cattle; Cell Line; Chlorocebus aethiops; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; DNA, Viral; Gene Dosage; Genome, Viral; Lactones; Leupeptins; Multienzyme Complexes; Mutagenesis, Site-Directed; Papilloma; Papillomavirus Infections; Phosphorylation; Proteasome Endopeptidase Complex; Serine; Viral Proteins; Warts | 2000 |
Prevention of etoposide-induced apoptosis by proteasome inhibitors in a human leukemic cell line but not in fresh acute leukemia blasts. A differential role of NF-kappab activation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Etoposide; Humans; I-kappa B Proteins; Leupeptins; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; U937 Cells | 2000 |
The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Animals; beta-Galactosidase; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cholesterol; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Leupeptins; Lovastatin; Oligopeptides; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Tricarboxylic Acids; Ubiquitins | 2000 |
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.
Topics: Acetylcysteine; Adenosine Triphosphate; Antigens, Neoplasm; Cell Cycle; Cell Extracts; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Isoenzymes; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2001 |
Proteasome-mediated degradation of BRCA1 protein in MCF-7 human breast cancer cells.
Topics: Apoptosis; Blotting, Western; BRCA1 Protein; CDC2-CDC28 Kinases; Cell Cycle; Cyclin G; Cyclin G1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Humans; Leupeptins; Multienzyme Complexes; Paclitaxel; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Up-Regulation | 2001 |
Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.
Topics: Animals; Apoptosis; Cell Line; Cell Nucleus; Cysteine Endopeptidases; Cytoplasm; Down-Regulation; Endoribonucleases; Interferon-alpha; Leupeptins; Mice; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Transport; Tetradecanoylphorbol Acetate | 2003 |
Induction of apoptosis by the proteasome inhibitor MG132 in human HCC cells: Possible correlation with specific caspase-dependent cleavage of beta-catenin and inhibition of beta-catenin-mediated transactivation.
Topics: alpha Catenin; Amino Acid Chloromethyl Ketones; Apoptosis; beta Catenin; Carcinoma, Hepatocellular; Caspase Inhibitors; Caspases; Cell Division; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Cytosol; Desmoplakins; DNA-Binding Proteins; G2 Phase; gamma Catenin; Humans; Inhibitor of Apoptosis Proteins; Leupeptins; Lymphoid Enhancer-Binding Factor 1; Microtubule-Associated Proteins; Neoplasm Proteins; Oligopeptides; Peptide Fragments; Proto-Oncogene Proteins c-myc; RNA, Messenger; Survivin; Trans-Activators; Transcription Factors; Transcriptional Activation | 2004 |
Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.
Topics: Acetylcysteine; Antioxidants; Cell Cycle Proteins; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; Glutathione; Humans; Leupeptins; Multienzyme Complexes; Osteosarcoma; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.
Topics: 14-3-3 Proteins; Cell Line; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytoplasm; Enzyme Inhibitors; Histone Deacetylases; Humans; Leupeptins; Marine Toxins; Models, Biological; Mutation; Oxazoles; Peptide Hydrolases; Phosphorylation; Plasmids; Proteasome Endopeptidase Complex; Protein Binding; Protein Biosynthesis; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine 3-Monooxygenase; Up-Regulation | 2004 |
Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation.
Topics: Animals; Antibodies; Cell Cycle Proteins; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Female; Fertilization in Vitro; Leupeptins; MAP Kinase Signaling System; Meiosis; Mice; Oocytes; Parthenogenesis; Polo-Like Kinase 1; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Subcellular Fractions; Ubiquitin | 2004 |
Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.
Topics: Animals; Aorta, Thoracic; Cell Line; Cells, Cultured; Dependovirus; DNA, Viral; Endothelial Cells; Genetic Therapy; Genetic Vectors; Humans; Leupeptins; Mice; Muscle, Smooth, Vascular; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Inbred WKY; Saphenous Vein; Serotyping; Transduction, Genetic | 2005 |
Degradation of perilipin is mediated through ubiquitination-proteasome pathway.
Topics: Animals; Carrier Proteins; CHO Cells; Cricetinae; Culture Media; Fatty Acids; Leupeptins; Oleic Acid; Perilipin-1; Phosphoproteins; Proteasome Endopeptidase Complex; Recombinant Proteins; Transfection; Triglycerides; Ubiquitin | 2006 |
In vivo heteromer formation. Expression of soluble betaA4-crystallin requires coexpression of a heteromeric partner.
Topics: Animals; beta-Crystallin A Chain; beta-Crystallin B Chain; beta-Crystallins; Cricetinae; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Heat-Shock Proteins; HeLa Cells; HSP70 Heat-Shock Proteins; Humans; Isoelectric Focusing; Leupeptins; Luciferases; Molecular Chaperones; Mutation; Protein Folding; Solubility | 2006 |
Antioxidants block proteasome inhibitor function in endometrial carcinoma cells.
Topics: Antioxidants; Antipyrine; Apoptosis; Ascorbic Acid; Blotting, Western; Boronic Acids; Bortezomib; Butylated Hydroxyanisole; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Coumarins; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Edaravone; Endometrial Neoplasms; Ergothioneine; Female; Humans; Leupeptins; Oligopeptides; Proteasome Inhibitors; Pyrazines; Ubiquitin; Vitamin E; Vitamins | 2008 |
Down-regulation of brain-pancreas relative protein in diabetic rats and by high glucose in PC12 cells: prevention by calpain inhibitors.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Dipeptides; Down-Regulation; Glucose; Half-Life; Hippocampus; Insulin; Leupeptins; Male; Nerve Tissue Proteins; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Time Factors | 2008 |
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Topics: Animals; Ataxin-3; Blotting, Western; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Gene Expression; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Leupeptins; Machado-Joseph Disease; Molecular Chaperones; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Peptides; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Physiological; Transfection | 2009 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.
Topics: Acetylcysteine; Ammonium Chloride; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Gene Knockout Techniques; HEK293 Cells; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leupeptins; Lysosomes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Presenilin-1; Presenilin-2; Proteasome Inhibitors; Proteolysis; Receptor, Notch1; Transcription, Genetic; Transcriptional Activation; Ubiquitination | 2012 |
Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.
Topics: Adenine; Animals; Autophagy; Carboxylic Ester Hydrolases; Cycloheximide; Green Fluorescent Proteins; HEK293 Cells; Humans; Leupeptins; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Structure, Tertiary; Proteolysis; Recombinant Fusion Proteins | 2012 |
Proteasome inhibition in cancer is associated with enhanced tumor targeting by the adeno-associated virus/phage.
Topics: Animals; Bacteriophages; Cell Line; Cell Line, Tumor; Dependovirus; Fluorescent Antibody Technique; Humans; Leupeptins; Mice; Proteasome Endopeptidase Complex | 2013 |
Proteasome Inhibitors Bortezomib and Carfilzomib Stimulate the Transport Activity of Human Organic Anion Transporter 1.
Topics: Antineoplastic Agents; Biological Transport, Active; Bortezomib; HEK293 Cells; Humans; Leupeptins; Oligopeptides; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ubiquitination | 2020 |