acetylleucyl-leucyl-norleucinal and atorvastatin

acetylleucyl-leucyl-norleucinal has been researched along with atorvastatin in 2 studies

Compound Research Comparison

Studies (acetylleucyl-leucyl-norleucinal)	Trials (acetylleucyl-leucyl-norleucinal)	Recent Studies (post-2010) (acetylleucyl-leucyl-norleucinal)	Studies (atorvastatin)	Trials (atorvastatin)	Recent Studies (post-2010) (atorvastatin)
321	0	53	7,420	2,058	3,782

Protein Interaction Comparison

Protein	Taxonomy	atorvastatin (IC50)
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Homo sapiens (human)	0.0064
Insulin receptor	Rattus norvegicus (Norway rat)	0.0002
Prostaglandin G/H synthase 2	Homo sapiens (human)	0.0002
3-hydroxy-3-methylglutaryl-coenzyme A reductase	Rattus norvegicus (Norway rat)	0.0054
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	4.3
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	1

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Balligand, JL; Desager, JP; Dessy, C; Feron, O	1

Other Studies

2 other study(ies) available for acetylleucyl-leucyl-norleucinal and atorvastatin

Article	Year
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation, 2001, Jan-02, Volume: 103, Issue:1 Topics: Animals; Atorvastatin; Cattle; Caveolin 1; Caveolins; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Cholesterol; Cholesterol, LDL; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Heptanoic Acids; HSP90 Heat-Shock Proteins; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leupeptins; Lipoproteins, LDL; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrroles; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Up-Regulation	2001

Article

Year

Identifying off-target effects and hidden phenotypes of drugs in human cells.

Nature chemical biology, 2006, Volume: 2, Issue:6

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006

Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance.

Circulation, 2001, Jan-02, Volume: 103, Issue:1

Topics: Animals; Atorvastatin; Cattle; Caveolin 1; Caveolins; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Cholesterol; Cholesterol, LDL; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Endothelium, Vascular; Heptanoic Acids; HSP90 Heat-Shock Proteins; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leupeptins; Lipoproteins, LDL; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pyrroles; Sterol Regulatory Element Binding Protein 1; Transcription Factors; Up-Regulation

2001