acetylisoniazid has been researched along with isoniazid in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (49.02) | 18.7374 |
| 1990's | 10 (19.61) | 18.2507 |
| 2000's | 5 (9.80) | 29.6817 |
| 2010's | 11 (21.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Latino, DA; Martins, F; Ventura, C | 1 |
| Aires-de-Sousa, J; Correia, HF; Elvas-Leitão, R; Kovalishyn, V; Latino, DA; Martins, F; Miranda, V; Ramos, J; Reis, M; Santos, L; Santos, S; Ventura, C; Vitorino, S; Viveiros, M | 1 |
| Aiub, CAF; Araujo-Lima, CF; Boechat, N; Castelo-Branco, FS; Costa, TEMM; Costa-Lima, MM; de Lima, EC; Domingos, JLO; Felzenszwalb, I; Gomes, KM; Henriques, MG; Lourenço, MCS; Penido, C; Pinto, AC | 1 |
| Cheng, WB; Li, D; Wang, ZY; Zhang, RL | 1 |
| Breda, M; Carpentieri, M; Efthymiopoulos, C; Pianezzola, E; Rimoldi, R; Sassella, D; Strolin Benedetti, M | 1 |
| Bleyer, H; Franke, G; Siegmund, W; Walter, R; Zeruesenay, D; Zschiesche, M | 1 |
| el-Yazigi, A; Raines, DA | 1 |
| Ashtekar, DR; Farhi, DC; Gangadharam, PR; Wise, DL | 1 |
| Lütjohann, D; Musch, E; Peter, MG; Schwabe, HK | 1 |
| Ellard, GA; Jenner, PJ | 1 |
| el-Sayed, YM; Islam, SI | 1 |
| Leneveu, A; Miscoria, G; Roux, A; Walle, C | 1 |
| Hutchings, A; Routledge, PA; Spragg, BP | 1 |
| Hutchings, AD; Monie, RD; Routledge, PA; Spragg, BP | 1 |
| Ioannou, PC | 1 |
| Thomas, BH; Whitehouse, LW; Zeitz, W | 2 |
| Arias, TD; Inaba, T | 1 |
| Hutchings, A; Routledge, PA | 1 |
| Castro-Parra, M; Eichelbaum, M; Musch, E; von Sassen, W | 1 |
| Ericsson, O; Muchtar, A; Svensson, JO | 1 |
| Acocella, G; Conti, R; Grassi, C; Luisetti, M; Pozzi, E | 1 |
| Lauterburg, BH; Mitchell, JR; Smith, CV; Todd, EL | 1 |
| Timbrell, JA; Wright, JM | 1 |
| Yan, DX | 1 |
| Hutchings, A; Monie, RD; Routledge, PA; Spragg, B | 2 |
| Goulle, JP; Lacroix, C; Laine, G; Nouveau, J | 1 |
| Frobert, Y; Guillaumont, M; Guise, B; Harf, R; Leclercq, M | 1 |
| Horai, Y; Iguchi, S; Ishizaki, T; Koya, G; Matsuyama, K | 1 |
| Albessard, F; Camsonne, R; Lacotte, J; Moulin, MA | 1 |
| Downs, PA; Ellard, GA; Jenner, PJ | 1 |
| Cha, YN; Han, JS; Jang, IJ; Kim, S; Kim, YG; Lee, JS; Shin, JG; Shin, SG | 1 |
| Katayama, T; Kohno, H; Mori, M | 1 |
| Hanaoka, T; Hashida, C; Ishizu, S; Maeda, K; Ohishi, Y | 1 |
| Eto, S; Jitsufuchi, N; Noda, A; Noda, H; Ono, Y; Zaima, Y | 1 |
| Aït Moussa, L; Bégaud, B; Hüe, B; Jana, M; Khassouani, CE; Soulaymani, R | 1 |
| MCKENNIS, H; YARD, AS | 1 |
| KAERKELAE, A; MIETTINEN, P; TUOVINEN, E | 1 |
| Cao, XM; Chen, B; Li, JH; Wang, J; Xu, YM | 1 |
| Christians, U; Hybertson, B; Ng, KY; Randolph, T; Zhang, YL; Zhou, H | 1 |
| Jun, SH; Kim, JQ; Lee, JH; Park, KU; Song, J; Song, SH; Yoon, Y | 1 |
| Kwon, SY; Lee, CT; Lee, JH; Lee, SW; Park, KU; Song, J; Um, SW; Yoon, HI | 1 |
| Jiang, JM; Liu, P; Zhou, ZF | 1 |
| Amini, M; Dashti-Khavidaki, S; Hajiabdolbaghi, M; Khalili, H; Mahjub, R | 1 |
| Chen, L; Liu, P; Shen, M; Zhou, Z; Zou, F | 1 |
| Bing, C; Jinhenga, L; Xiaomeia, C | 1 |
| Aarnoutse, RE; Coenen, MJ; de Waard, JH; García, JF; Hermans, PW; López, D; Schijvenaars, MM; Verhagen, LM | 1 |
| Amlabu, V; Evans, A; Gray, D; Jele, N; McIlleron, H; Mulligan, C; Smith, P; Zar, HJ | 1 |
| Hee, KH; Lee, LS; Seo, JJ | 1 |
| Chew, N; Hee, KH; Khoo, SH; Lee, LS; Seng, KY; Soon, GH | 1 |
3 trial(s) available for acetylisoniazid and isoniazid
| Article | Year |
|---|---|
Decreased acetylation of isoniazid in chronic renal failure.
Topics: Acetylation; Adolescent; Adult; Evaluation Studies as Topic; Female; Humans; Isoniazid; Kidney Failure, Chronic; Kidney Transplantation; Liver; Male; Middle Aged | 1993 |
Low serum concentrations of anti-tuberculosis drugs and determinants of their serum levels.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antitubercular Agents; Chromatography, Liquid; Drug Monitoring; Ethambutol; Female; Humans; Isoniazid; Linear Models; Male; Mass Spectrometry; Middle Aged; Pyrazinamide; Rifampin; Tuberculosis | 2007 |
Isoniazid/acetylisoniazid urine concentrations: markers of adherence to isoniazid preventive therapy in children.
Topics: Age Factors; Antitubercular Agents; Biomarkers; Biotransformation; Child; Chromatography, High Pressure Liquid; Coinfection; Colorimetry; Drug Monitoring; HIV Infections; Humans; Isoniazid; Medication Adherence; Predictive Value of Tests; Primary Prevention; Reproducibility of Results; South Africa; Tandem Mass Spectrometry; Tuberculosis | 2014 |
48 other study(ies) available for acetylisoniazid and isoniazid
| Article | Year |
|---|---|
Comparison of Multiple Linear Regressions and Neural Networks based QSAR models for the design of new antitubercular compounds.
Topics: Antitubercular Agents; Dose-Response Relationship, Drug; Drug Design; Linear Models; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Neural Networks, Computer; Quantitative Structure-Activity Relationship | 2013 |
Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity.
Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Isoniazid; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship; Vero Cells | 2014 |
New hydrazides derivatives of isoniazid against Mycobacterium tuberculosis: Higher potency and lower hepatocytotoxicity.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Hydrazines; Isoniazid; Macrophages; Mice; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship | 2018 |
Effects of rifampicin on pharmacokinetics of isoniazid and its metabolite acetylhydrazine in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Interactions; Hydrazines; Isoniazid; Male; Rats; Rats, Wistar; Rifampin | 1992 |
A study of the effects of rifabutin on isoniazid pharmacokinetics and metabolism in healthy volunteers.
Topics: Acetylation; Adult; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Half-Life; Humans; Isoniazid; Male; Phenotype; Rifabutin; Rifamycins; Spectrophotometry, Ultraviolet | 1992 |
Pharmacokinetic interactions between isoniazid and theophylline in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Interactions; Half-Life; Isoniazid; Male; Rats; Rats, Wistar; Theophylline | 1992 |
Simultaneous microdetermination of rifampin, deacetylrifampin, isoniazid, and acetylisoniazid in plasma by liquid chromatography with dual electrochemical and spectrophotometric detection.
Topics: Chromatography, Liquid; Electrochemistry; Isoniazid; Microchemistry; Rifampin; Spectrophotometry | 1992 |
Sustained release of isoniazid in vivo from a single implant of a biodegradable polymer.
Topics: Biocompatible Materials; Delayed-Action Preparations; Drug Implants; Humans; Isoniazid; Lactic Acid; Liver; Lung; Mycobacterium tuberculosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Tuberculosis | 1991 |
[A high pressure liquid chromatography method for detecting the isoniazid derivative isonicotinoyl-hydrazine sodium glucuronide, free isoniazid and acetylisoniazid and its use in pharmacologic studies].
Topics: Acetylation; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Humans; Isoniazid; Phenotype; Tuberculosis, Pulmonary | 1990 |
Isoniazid-related hepatotoxicity: a study of the effect of rifampicin administration on the metabolism of acetylisoniazid in man.
Topics: Acetylation; Adult; Carcinogens; Humans; Hydrazines; Isoniazid; Liver; Male; Rifampin | 1989 |
Acetylation phenotyping of isoniazid using a simple and accurate high-performance liquid chromatography.
Topics: Acetylation; Adolescent; Adult; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Isoniazid; Male; Middle Aged; Phenotype; Regression Analysis | 1989 |
[Application of a method of analysis using high performance liquid chromatography of isoniazid and acetylisoniazid to determine the phenotype of acetylation].
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, High Pressure Liquid; Half-Life; Humans; Infant; Isoniazid; Middle Aged; Phenotype; Spectrophotometry, Ultraviolet; Time Factors | 1988 |
Stability of isoniazid and acetylisoniazid in saliva.
Topics: Drug Stability; Humans; Isoniazid; Saliva; Temperature | 1988 |
Saliva and plasma concentrations of isoniazid and acetylisoniazid in man.
Topics: Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Injections, Intravenous; Isoniazid; Male; Middle Aged; Protein Binding; Saliva | 1988 |
A more simple, rapid and sensitive fluorimetric method for the determination of isoniazid and acetylisoniazid in serum. Application for acetylator phenotyping.
Topics: Acetonitriles; Acetylation; Blood Proteins; Humans; Isoniazid; Phenotype; Spectrometry, Fluorescence; Tuberculosis | 1988 |
Effect of rifampin, phenobarbital pretreatment, and acetylator phenotype on acetylisoniazid metabolism in the rabbit.
Topics: Acetylation; Animals; Isoniazid; Kinetics; Liver; Male; Phenobarbital; Phenotype; Protein Binding; Rabbits; Rifampin; Tissue Distribution | 1987 |
On phenotyping with isoniazid: the use of urinary acetylation ratio and the uniqueness of antimodes. Study of two Amerindian populations.
Topics: Acetylation; Acetyltransferases; Adolescent; Adult; Female; Humans; Indians, Central American; Isoniazid; Liver; Male; Methods; Middle Aged; Panama; Phenotype; Time Factors | 1987 |
A simple method for determining acetylator phenotype using isoniazid.
Topics: Acetylation; Half-Life; Humans; Isoniazid; Phenotype | 1986 |
Determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine in biological fluids by high-performance liquid chromatography.
Topics: Body Fluids; Chromatography, High Pressure Liquid; Humans; Hydrazines; Hydrolysis; Isoniazid; Kinetics; Spectrophotometry, Ultraviolet | 1985 |
Ion-pair high-performance liquid chromatographic determination of isoniazid and acetylisoniazid in plasma and urine. Application for acetylator phenotyping.
Topics: Acetylation; Chromatography, High Pressure Liquid; Half-Life; Humans; Isoniazid; Kidney Diseases; Phenotype; Spectrophotometry, Ultraviolet; Ultrafiltration | 1985 |
Pharmacokinetic studies on antituberculosis regimens in humans. I. Absorption and metabolism of the compounds used in the initial intensive phase of the short-course regimens: single administration study.
Topics: Absorption; Antitubercular Agents; Humans; Isoniazid; Kinetics; Male; Pyrazinamide; Rifampin; Streptomycin | 1985 |
Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.
Topics: Acetylation; Adult; Female; Half-Life; Humans; Hydrazines; Isoniazid; Kinetics; Liver; Male | 1985 |
Metabolism of [14C]acetylisoniazid and [14C]acetylhydrazine by the rat and rabbit.
Topics: Animals; Biotransformation; Carbon Radioisotopes; Hydrazines; Isoniazid; Kinetics; Male; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Tissue Distribution | 1984 |
Urinary metabolic profile of isoniazid in patients who develop isoniazid-related liver damage.
Topics: Acetylation; Adult; Aged; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; Humans; Hydrazines; Isoniazid; Kinetics; Male; Middle Aged; Phenotype | 1984 |
[Determination of isoniazid and acetylisoniazid in the urine for phenotyping isoniazid inactivators].
Topics: Acetylation; Adult; Female; Humans; Inactivation, Metabolic; Isoniazid; Male; Phenotype | 1983 |
High-performance liquid chromatographic analysis of isoniazid and acetylisoniazid in biological fluids.
Topics: Chromatography, High Pressure Liquid; Humans; Isoniazid; Kinetics | 1983 |
[Microanalysis of plasma isoniazid and acetylisoniazid by high performance liquid chromatography].
Topics: Acrolein; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Densitometry; Humans; Isoniazid; Spectrometry, Fluorescence | 1984 |
A method to prevent the loss of isoniazid and acetylisoniazid in human plasma.
Topics: Humans; Isoniazid; Specimen Handling; Temperature | 1983 |
Determination of rifampicin, desacetylrifampicin, isoniazid and acetylisoniazid by high-performance liquid chromatography: application to human serum extracts, polymorphonucleocytes and alveolar macrophages.
Topics: Chromatography, High Pressure Liquid; Humans; Isoniazid; Macrophages; Neutrophils; Rifampin; Tuberculosis, Pulmonary | 1982 |
Acetylator phenotype and metabolic disposition of isoniazid in Japanese patients with systemic lupus erythematosus.
Topics: Acetylation; Adolescent; Adult; Asian People; Female; Humans; Hydrazines; Isoniazid; Japan; Lupus Erythematosus, Systemic; Male; Middle Aged; Phenotype | 1981 |
Hydrophilic ion-pair reversed-phase high-performance liquid chromatography for the simultaneous assay of isoniazid and acetylisoniazid in serum: a microscale procedure.
Topics: Chromatography, High Pressure Liquid; Half-Life; Humans; Isoniazid | 1981 |
An evaluation of the potential use of isoniazid, acetylisoniazid and isonicotinic acid for monitoring the self-administration of drugs.
Topics: Glycine; Half-Life; Humans; Intestinal Absorption; Isoniazid; Isonicotinic Acids; Male; Patient Compliance; Riboflavin; Self Administration; Time Factors | 1980 |
[Testing for heterogeneity in genetic polymorphism of N-acetylation using isoniazid by metameters--probit, logit, and arcsine transformation].
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Data Interpretation, Statistical; Female; Humans; Isoniazid; Japan; Logistic Models; Male; Middle Aged; Nitrogen; Polymorphism, Genetic; Tuberculosis, Pulmonary | 1993 |
N-acetyltransferase activity in the urine in Japanese subjects: comparison in healthy persons and bladder cancer patients.
Topics: Acetylation; Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase; Asian People; Disease Susceptibility; Female; Genetic Predisposition to Disease; Humans; Isoniazid; Japan; Male; Middle Aged; Neoplasm Proteins; Occupational Diseases; Occupational Exposure; Phenotype; Smoking; Urinary Bladder Neoplasms | 1995 |
Determination of isonicotinic acid in the presence of isoniazid and acetylisoniazid. Studies on isonicotinic acid formation from isoniazid in isolated rat hepatocytes.
Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Isoniazid; Isonicotinic Acids; Liver; Rats; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1996 |
Determination of the acetylator phenotype in Moroccan tuberculosis patients using isoniazid as metabolic probe.
Topics: Acetylation; Adolescent; Adult; Aged; Antitubercular Agents; Arylamine N-Acetyltransferase; Female; Humans; Isoniazid; Male; Metabolic Clearance Rate; Middle Aged; Phenotype; Polymorphism, Genetic; Tuberculosis, Pulmonary | 2002 |
ASPECTS OF THE METABOLISM OF ISONIAZID AND ACETYLISONIAZID IN THE HUMAN AND THE DOG.
Topics: Dogs; Humans; Isoniazid; Metabolism; Research | 1962 |
COMPARATIVE STUDIES IN ISONIAZID AND ACETYLISONIAZID CONCENTRATIONS IN AQUEOUS HUMOUR AND SERUM.
Topics: Aqueous Humor; Blood Chemical Analysis; Chorioretinitis; Chromatography; Eye; Glaucoma; Humans; Isoniazid; Retinitis; Sclera; Tuberculosis; Tuberculosis, Ocular; Uveitis | 1963 |
The influence of NAT2 genotypes on the plasma concentration of isoniazid and acetylisoniazid in Chinese pulmonary tuberculosis patients.
Topics: Antitubercular Agents; Arylamine N-Acetyltransferase; China; Chromatography, High Pressure Liquid; Genotype; Heterozygote; Homozygote; Humans; Isoniazid; Tuberculosis, Pulmonary | 2006 |
Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Isoniazid; Macrophages, Alveolar; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |
Simultaneous determination of first-line anti-tuberculosis drugs and their major metabolic ratios by liquid chromatography/tandem mass spectrometry.
Topics: Antitubercular Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Complex Mixtures; Humans; Isoniazid; Rifampin; Spectrometry, Mass, Electrospray Ionization | 2007 |
[High-performance liquid chromatography for detecting the concentrations of isoniazid and acetylisoniazid in spinal tuberculosis].
Topics: Adult; Aged; Antitubercular Agents; Chromatography, High Pressure Liquid; Female; Humans; Isoniazid; Lumbar Vertebrae; Male; Middle Aged; Tuberculosis, Spinal; Young Adult | 2010 |
Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects?
Topics: Acetylation; Adolescent; Adult; Antitubercular Agents; Biotransformation; Case-Control Studies; Female; Humans; Iran; Isoniazid; Male; Middle Aged; Phenotype; Tuberculosis; Young Adult | 2010 |
Simultaneous determination of isoniazid, pyrazinamide, rifampicin and acetylisoniazid in human plasma by high-performance liquid chromatography.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Isoniazid; Pyrazinamide; Rifampin; Sensitivity and Specificity | 2010 |
Gene dose effect of NAT2 variants on the pharmacokinetics of isoniazid and acetylisoniazid in healthy Chinese subjects.
Topics: Adult; Antitubercular Agents; Arylamine N-Acetyltransferase; Asian People; Gene Dosage; Humans; Isoniazid; Male; Mutation; Young Adult | 2011 |
Full-gene sequencing analysis of NAT2 and its relationship with isoniazid pharmacokinetics in Venezuelan children with tuberculosis.
Topics: Adolescent; Arylamine N-Acetyltransferase; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Genotype; Humans; Infant; Isoniazid; Male; Phenotype; Polymorphism, Single Nucleotide; Tuberculosis; Venezuela | 2014 |
Development and validation of liquid chromatography tandem mass spectrometry method for simultaneous quantification of first line tuberculosis drugs and metabolites in human plasma and its application in clinical study.
Topics: Antitubercular Agents; Chromatography, High Pressure Liquid; Humans; Isoniazid; Rifampin; Solid Phase Extraction; Tandem Mass Spectrometry | 2015 |
Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers.
Topics: Arylamine N-Acetyltransferase; Chromatography, Liquid; Cross-Over Studies; Genotype; Healthy Volunteers; Humans; Isoniazid; Isonicotinic Acids; Polymorphism, Single Nucleotide; Prospective Studies; Tandem Mass Spectrometry | 2015 |