Compounds > acetylglucosamine
Page last updated: 2024-08-22

acetylglucosamine and thiazoles

acetylglucosamine has been researched along with thiazoles in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (4.65)18.2507
2000's11 (25.58)29.6817
2010's26 (60.47)24.3611
2020's4 (9.30)2.80

Authors

AuthorsStudies
Csáthy, L; Oláh, VA; Pócsi, I; Price, RG1
Aamlid, KH; Pócsi, I; Price, RG; Richardson, AC; Smith, BV; Taylor, SA1
James, MN; Knapp, S; Mark, BL; Triggs-Raine, BL; Vocadlo, DJ; Withers, SG1
Csáthy, L; Oláh, AV; Oláh, E; Országh, E; Price, RG; Varga, J1
Blackburn, NT; Clarke, AJ; Reid, CW1
Auzanneau, FI; Blackburn, NT; Clarke, AJ; Legaree, BA; Reid, CW1
Chin, D; Debowski, AW; Macauley, MS; Vocadlo, DJ; Whitworth, GE1
Cherney, MM; James, MN; Lemieux, MJ; Mahuran, DJ; Mark, BL; Withers, SG1
Black, GW; Charnock, SJ; Davies, GJ; Macauley, MS; Robinson, CE; Sheldon, WL; Taylor, EJ; Vocadlo, DJ1
Davies, GJ; Dennis, RJ; Greig, IR; Macauley, MS; Stubbs, KA; Taylor, EJ; Vocadlo, DJ; Whitworth, GE1
Bezouska, K; Charvátová-Pisvejcová, A; Hofbauerová, K; Kavan, D; Kren, V; Man, P; Novák, P; Plíhal, O; Pompach, P; Ryslavá, H; Sklenár, J; Weignerová, L1
Collyer, CA; Guss, JM; Harty, DW; Hunter, N; Jacques, NA; Langley, DB1
Alves, CN; Kanaan, N; Lameira, J; Martí, S; Moliner, V; Tuñón, I1
Macauley, MS; Vocadlo, DJ1
Abdalla, FH; Bellé, LP; Bitencourt, PE; De Bona, KS; Moretto, MB; Pigatto, AS1
Abdo, M; Darout, E; Hanover, JA; Kim, EJ; Knapp, S; Love, DC; Rablen, PR; Rempel, B; Withers, SG1
Brocks, CA; Chatham, JC; Laczy, B; Marsh, SA; Wittmann, I1
Clark, T; Macauley, MS; Shan, X; Skorobogatko, Y; Vocadlo, DJ; Vosseller, K; Yuzwa, SA1
Alves, CN; de Alencar, NA; Lameira, J; Martí, S; Moliner, V; Silva, JR; Sousa, PR1
Chatham, JC; Marchase, RB; Marsh, SA; Zhu-Mauldin, X; Zou, L1
Jin, FZ; Wu, MJ; Yang, Z; Yu, C; Zhao, DZ1
Caro, S; Lanza, C; Potnis, A; Slawson, C; Tan, EP1
Carlson, GA; Dellovade, TL; Graham, DL; Gray, AJ; Hering, H; Joyce, JA; O'Moore, J; Shearman, MS; Yu, D1
Bradley, WE; Chatham, JC; Chen, Y; Dell'Italia, LJ; Heath, JM; Litovsky, S; Sun, Y; Wu, H; Yuan, K1
Bojarová, P; Cvačka, J; Ettrich, R; Kalachova, L; Krejzová, J; Křen, V; Kulik, N; Marhol, P; Pelantová, H; Simon, P; Slámová, K1
Liu, T; Shen, X; Wang, J; Xia, M; Yang, Q; Zhang, H; Zhou, H1
Kalachova, L; Krejzová, J; Křen, V; Pelantová, H; Šimon, P; Slámová, K1
Chen, W; Dong, Y; Kong, H; Lu, H; Wang, D; Yang, Q; Zhang, J1
Banerjee, P; Hart, GW; Liu, T; Ma, J; O'Rourke, B; Wei, AC1
Krejzová, J; Křen, V; Kulik, N; Slámová, K1
Chen, W; Dong, Y; Jin, S; Kong, H; Liang, X; Liu, T; Lu, H; Yang, Q; Zhang, J1
Chien, J; de Queiroz, RM; Dias, WB; Madan, R; Slawson, C1
Davies, GJ; Goddard-Borger, ED; John, A; Petricevic, M; Roth, C; Williams, SJ1
Chen, YJ; Chiang, MF; Gao, S; Khoo, KH; Lin, CC; Lin, CH; Lin, KI; Tsai, DY; Wu, HY; Wu, JL1
Hao, J; He, Y; Li, D; Ma, X1
Jiang, M; Li, Y; Liu, S; Paschen, W; Sheng, H; Warner, DS; Yang, W; Yu, S; Yu, Z1
Asahi, M; Higuchi, K; Inoue, Y; Moriwaki, K; Takeuchi, T; Ueda, Y1
Blumberg, RS; Cheng, M; Han, X; Huang, Z; Nie, Y; Ren, K; Ruan, HB; Sahu, C; Wu, K; Xiong, X; Xu, B; Zhao, M1
Hwang, H; Rhim, H1
Baldini, S; Decourcelle, A; Dehennaut, V; Leprince, D; Loison, I1
Aunkham, A; Bulmer, DM; Kaewmaneewat, A; Kardkuntod, A; Meekrathok, P; Stubbs, KA; Suginta, W; van den Berg, B1
Cork, GK; Flax, J; Griffith, S; Miller, R; Qiang, A; Slawson, C; Swerdlow, RH; Thompson, J; Wilkins, HM1
Almanasra, A; Havranek, B; Islam, SM1

Reviews

1 review(s) available for acetylglucosamine and thiazoles

ArticleYear
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.
    Biochimica et biophysica acta, 2010, Volume: 1800, Issue:2

    Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; N-Acetylglucosaminyltransferases; Oximes; Phenylcarbamates; Pyrazoles; Pyridines; Streptozocin; Thiazoles; Uridine Diphosphate N-Acetylglucosamine

2010

Other Studies

42 other study(ies) available for acetylglucosamine and thiazoles

ArticleYear
Assay of N-acetyl-beta-D-glucosaminidase in urine from neonates: comparison of two new colorimetric methods using MNP-GlcNAc and VRA-GlcNAc as substrates.
    Annals of clinical biochemistry, 1992, Volume: 29 ( Pt 3)

    Topics: Acetylglucosamine; Acetylglucosaminidase; Female; Humans; Infant, Newborn; Male; Methods; Thiazoles

1992
"VRA-GlcNAc": novel substrate for N-acetyl-beta-D-glucosaminidase applied to assay of this enzyme in urine.
    Clinical chemistry, 1990, Volume: 36, Issue:11

    Topics: Acetylglucosamine; Acetylglucosaminidase; Diabetes Mellitus; Humans; Hydrogen-Ion Concentration; Kinetics; Substrate Specificity; Temperature; Thiazoles

1990
Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.
    The Journal of biological chemistry, 2001, Mar-30, Volume: 276, Issue:13

    Topics: Acetylglucosamine; Aspartic Acid; beta-N-Acetylhexosaminidases; Catalysis; Crystallography, X-Ray; Electrons; Escherichia coli; Gangliosidoses; Models, Chemical; Models, Molecular; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Spectroscopy, Fourier Transform Infrared; Streptomyces; Thiazoles; Tryptophan

2001
Age dependence of serum beta-N-acetylhexosaminidase (NAG) activity.
    Clinical chemistry and laboratory medicine, 2004, Volume: 42, Issue:3

    Topics: Acetylglucosamine; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; beta-N-Acetylhexosaminidases; Catalysis; Child; Child, Preschool; Clinical Enzyme Tests; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Reference Values; Spectrum Analysis; Statistical Distributions; Thiazoles

2004
The effect of NAG-thiazoline on morphology and surface hydrophobicity of Escherichia coli.
    FEMS microbiology letters, 2004, May-15, Volume: 234, Issue:2

    Topics: Acetylglucosamine; Cell Membrane; Escherichia coli; Lipopolysaccharides; Microscopy, Phase-Contrast; Thiazoles

2004
Inhibition of membrane-bound lytic transglycosylase B by NAG-thiazoline.
    FEBS letters, 2004, Sep-10, Volume: 574, Issue:1-3

    Topics: Acetylglucosamine; Base Sequence; DNA Primers; Enzyme Inhibitors; Glycoside Hydrolases; Glycosyltransferases; Membrane Proteins; Mutagenesis, Site-Directed; Thiazoles

2004
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.
    The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27

    Topics: Acetylglucosamine; Acetylglucosaminidase; Acetyltransferases; Animals; beta-N-Acetylhexosaminidases; Catalysis; Chlorocebus aethiops; COS Cells; Enzyme Activation; Glycoconjugates; Histone Acetyltransferases; Humans; Lysosomes; Multienzyme Complexes; Substrate Specificity; Thiazoles

2005
Crystallographic structure of human beta-hexosaminidase A: interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis.
    Journal of molecular biology, 2006, Jun-16, Volume: 359, Issue:4

    Topics: Acetylglucosamine; Amino Acid Substitution; Arginine; Aspartic Acid; beta-N-Acetylhexosaminidases; Binding Sites; Crystallography, X-Ray; Dimerization; Gangliosidoses, GM2; Glycine; Glycosylation; Hexosaminidase A; Humans; Hydrolysis; Models, Molecular; Mutation; Protein Conformation; Protein Subunits; Tay-Sachs Disease; Thiazoles

2006
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase.
    The Biochemical journal, 2006, Oct-15, Volume: 399, Issue:2

    Topics: Acetylglucosamine; Acetylglucosaminidase; Amino Acid Sequence; Animals; beta-N-Acetylhexosaminidases; Catalysis; Chlorocebus aethiops; COS Cells; Escherichia coli; Histone Acetyltransferases; Humans; Hyaluronoglucosaminidase; Hydrolysis; Hymecromone; Kinetics; Molecular Sequence Data; Multienzyme Complexes; Nuclear Magnetic Resonance, Biomolecular; Sequence Homology, Amino Acid; Streptococcus pyogenes; Structure-Activity Relationship; Substrate Specificity; Thiazoles

2006
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.
    Journal of the American Chemical Society, 2007, Jan-24, Volume: 129, Issue:3

    Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Catalysis; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; Glycosylation; Humans; Models, Molecular; Oximes; Phenylcarbamates; Substrate Specificity; Thermodynamics; Thiazoles

2007
Large propeptides of fungal beta-N-acetylhexosaminidases are novel enzyme regulators that must be intracellularly processed to control activity, dimerization, and secretion into the extracellular environment.
    Biochemistry, 2007, Mar-13, Volume: 46, Issue:10

    Topics: Acetylglucosamine; Amino Acid Sequence; beta-N-Acetylhexosaminidases; Biological Transport; Catalysis; Dimerization; Endoplasmic Reticulum; Enzyme Activation; Enzyme Precursors; Enzyme Stability; Fungi; Furin; Molecular Sequence Data; Sequence Homology, Amino Acid; Thiazoles; Transcription, Genetic

2007
Structure of N-acetyl-beta-D-glucosaminidase (GcnA) from the endocarditis pathogen Streptococcus gordonii and its complex with the mechanism-based inhibitor NAG-thiazoline.
    Journal of molecular biology, 2008, Mar-14, Volume: 377, Issue:1

    Topics: Acetylglucosamine; Acetylglucosaminidase; Binding Sites; Crystallography, X-Ray; Dimerization; Endocarditis, Bacterial; Ligands; Models, Molecular; Protein Structure, Tertiary; Streptococcus gordonii; Thiazoles

2008
A quantum mechanics/molecular mechanics study of the protein-ligand interaction of two potent inhibitors of human O-GlcNAcase: PUGNAc and NAG-thiazoline.
    The journal of physical chemistry. B, 2008, Nov-13, Volume: 112, Issue:45

    Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Binding Sites; Biocatalysis; Drug Design; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Molecular Conformation; Oximes; Phenylcarbamates; Protein Binding; Protons; Quantum Theory; Static Electricity; Thermodynamics; Thiazoles

2008
Allium sativum L. extract prevents methyl mercury-induced cytotoxicity in peripheral blood leukocytes (LS).
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:1

    Topics: Acetylglucosamine; Adenosine Deaminase; Allium; Antioxidants; Cell Survival; Coloring Agents; Humans; Immunity, Cellular; In Vitro Techniques; Leukocytes; Methylmercury Compounds; Oxazines; Plant Extracts; Tetrazolium Salts; Thiazoles; Xanthenes

2010
OGA inhibition by GlcNAc-selenazoline.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: 3T3-L1 Cells; Acetylglucosamine; Adipocytes; Amino Acid Sequence; Animals; beta-N-Acetylhexosaminidases; Cell Differentiation; Cell Line; Clostridium perfringens; Enzyme Inhibitors; Glucosamine; Glucose Transporter Type 4; Glycosylation; HeLa Cells; Humans; Insulin; Mice; Models, Molecular; Molecular Sequence Data; Molecular Structure; Sequence Alignment; Structure-Activity Relationship; Thiazoles

2010
Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 299, Issue:5

    Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Desmin; Enzyme Inhibitors; Male; Models, Animal; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Thiazoles

2010
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
    Nature chemical biology, 2012, Feb-26, Volume: 8, Issue:4

    Topics: Acetylglucosamine; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Animals; Carbohydrate Conformation; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Mice; Mice, Transgenic; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; Neurons; Phosphorylation; Pyrans; tau Proteins; Thiazoles

2012
Computational analysis of human OGA structure in complex with PUGNAc and NAG-thiazoline derivatives.
    Journal of chemical information and modeling, 2012, Oct-22, Volume: 52, Issue:10

    Topics: Acetylglucosamine; Bacterial Proteins; Bacteroides; beta-N-Acetylhexosaminidases; Binding Sites; Clostridium perfringens; Crystallography, X-Ray; Humans; Isoenzymes; Kinetics; Ligands; Molecular Docking Simulation; Oximes; Phenylcarbamates; Protein Binding; Protein Conformation; Structural Homology, Protein; Thermodynamics; Thiazoles

2012
Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes.
    The Journal of biological chemistry, 2012, Nov-09, Volume: 287, Issue:46

    Topics: Acetylglucosamine; Animals; Calcium; Calcium Signaling; Cell Membrane; Gene Expression Regulation; Heart; Heart Ventricles; Humans; Membrane Glycoproteins; Muscle Cells; Myocardium; Myocytes, Cardiac; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Stromal Interaction Molecule 1; Thiazoles

2012
A correlation between altered O-GlcNAcylation, migration and with changes in E-cadherin levels in ovarian cancer cells.
    Experimental cell research, 2013, Jun-10, Volume: 319, Issue:10

    Topics: Acetylglucosamine; Antigens, CD; beta Catenin; Blotting, Western; Cadherins; Catenins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Delta Catenin; Female; Gene Silencing; Glycosylation; Humans; Multiprotein Complexes; N-Acetylglucosaminyltransferases; Ovarian Neoplasms; Oximes; Phenylcarbamates; Pyrans; RNA, Messenger; RNA, Small Interfering; Thiazoles; Transfection

2013
O-linked N-acetylglucosamine cycling regulates mitotic spindle organization.
    The Journal of biological chemistry, 2013, Sep-20, Volume: 288, Issue:38

    Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Chromosomes, Human; Enzyme Inhibitors; Glucosyltransferases; HeLa Cells; Histones; Humans; Phosphorylation; Protein Processing, Post-Translational; Pyrans; Spindle Apparatus; Thiazoles

2013
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
    Neuropharmacology, 2014, Volume: 79

    Topics: Acetylglucosamine; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Models, Animal; Female; Glycosylation; Male; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Phosphorylation; Pyrans; tau Proteins; Tauopathies; Thiazoles

2014
Activation of AKT by O-linked N-acetylglucosamine induces vascular calcification in diabetes mellitus.
    Circulation research, 2014, Mar-28, Volume: 114, Issue:7

    Topics: Acetylglucosamine; Animals; Aorta; beta-N-Acetylhexosaminidases; Core Binding Factor Alpha 1 Subunit; Diabetes Mellitus, Experimental; Glycosylation; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Muscle, Smooth, Vascular; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-akt; Pyrans; Thiazoles; TOR Serine-Threonine Kinases; Vascular Calcification

2014
Inhibition of GlcNAc-processing glycosidases by C-6-azido-NAG-thiazoline and its derivatives.
    Molecules (Basel, Switzerland), 2014, Mar-20, Volume: 19, Issue:3

    Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Catalytic Domain; Drug Stability; Glycoside Hydrolases; Models, Molecular; Molecular Conformation; Protein Binding; Thiazoles

2014
Exploring NAG-thiazoline and its derivatives as inhibitors of chitinolytic β-acetylglucosaminidases.
    FEBS letters, 2015, Jan-02, Volume: 589, Issue:1

    Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Enzyme Inhibitors; Insect Proteins; Molecular Dynamics Simulation; Moths; Thiazoles

2015
Inhibition of microbial β-N-acetylhexosaminidases by 4-deoxy- and galacto-analogues of NAG-thiazoline.
    Bioorganic & medicinal chemistry letters, 2014, Nov-15, Volume: 24, Issue:22

    Topics: Acetylglucosamine; Bacterial Proteins; Bacteroides; beta-N-Acetylhexosaminidases; Fungal Proteins; Fungi; Kinetics; Protein Binding; Streptomyces; Substrate Specificity; Thiazoles

2014
Synthesis of NAG-thiazoline-derived inhibitors for β-N-acetyl-d-hexosaminidases.
    Carbohydrate research, 2015, Sep-02, Volume: 413

    Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Lepidoptera; Substrate Specificity; Thiazoles

2015
O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function.
    The Journal of biological chemistry, 2015, Dec-04, Volume: 290, Issue:49

    Topics: Acetylglucosamine; Adenosine Triphosphate; Animals; Calcium; Glycomics; Heart; Male; Mass Spectrometry; Membrane Potentials; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Mitochondrial Proteins; Myocardium; Oxidative Phosphorylation; Oxygen; Permeability; Proteome; Proteomics; Pyrans; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Thiazoles

2015
Expression of human β-N-acetylhexosaminidase B in yeast eases the search for selective inhibitors.
    Enzyme and microbial technology, 2016, Volume: 89

    Topics: Acetylglucosamine; beta-Hexosaminidase beta Chain; Catalytic Domain; Enzyme Inhibitors; Gene Expression; Humans; Kinetics; Models, Molecular; Pichia; Recombinant Proteins; Thiazoles

2016
Synthesis of NAM-thiazoline derivatives as novel O-GlcNAcase inhibitors.
    Carbohydrate research, 2016, Jun-24, Volume: 429

    Topics: Acetylglucosamine; beta-N-Acetylhexosaminidases; Catalysis; Enzyme Inhibitors; Humans; Structure-Activity Relationship; Substrate Specificity; Thiazoles

2016
Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells.
    The Journal of biological chemistry, 2016, 09-02, Volume: 291, Issue:36

    Topics: Acetylglucosamine; Active Transport, Cell Nucleus; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Nucleus; Female; Gene Silencing; Homeostasis; Humans; Mutation; N-Acetylglucosaminyltransferases; Ovarian Neoplasms; Protein Processing, Post-Translational; Protein Stability; Pyrans; RNA, Messenger; RNA, Neoplasm; Thiazoles; Tumor Suppressor Protein p53

2016
Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation.
    Chemical communications (Cambridge, England), 2016, Sep-25, Volume: 52, Issue:74

    Topics: Acetylglucosamine; Bacteroides; beta-N-Acetyl-Galactosaminidase; Binding Sites; Catalytic Domain; Crohn Disease; Humans; Molecular Dynamics Simulation; Stereoisomerism; Substrate Specificity; Thiazoles

2016
Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells.
    Nature communications, 2016, 08-24, Volume: 7

    Topics: Acetylglucosamine; Animals; Apoptosis; B-Lymphocytes; beta-N-Acetylhexosaminidases; Calcium-Binding Proteins; Enzyme Inhibitors; Glycosylation; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microfilament Proteins; Phosphorylation; Protein Kinase C beta; Pyrans; Signal Transduction; Thiazoles

2016
Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017, Volume: 37, Issue:8

    Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Biomarkers; Disease Models, Animal; Macrophages; Male; Mice, Inbred C57BL; Microglia; N-Acetylglucosaminyltransferases; Neuroprotective Agents; Pyrans; Signal Transduction; Stroke; Thiazoles; Transcription Factor RelA

2017
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.
    Stroke, 2017, Volume: 48, Issue:6

    Topics: Acetylglucosamine; Age Factors; Animals; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotection; Protein Folding; Protein Serine-Threonine Kinases; Pyrans; Stroke; Thiazoles; Unfolded Protein Response; X-Box Binding Protein 1

2017
Elevated O-GlcNAcylation stabilizes FOXM1 by its reduced degradation through GSK-3β inactivation in a human gastric carcinoma cell line, MKN45 cells.
    Biochemical and biophysical research communications, 2018, 01-08, Volume: 495, Issue:2

    Topics: Acetylglucosamine; Acylation; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Proliferation; Diabetes Complications; Enzyme Inhibitors; Forkhead Box Protein M1; Glucose; Glycogen Synthase Kinase 3 beta; Humans; Protein Processing, Post-Translational; Protein Stability; Proteolysis; Pyrans; Stomach Neoplasms; Thiazoles; Ubiquitination; Up-Regulation

2018
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.
    EMBO molecular medicine, 2018, Volume: 10, Issue:8

    Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Colitis; Dysbiosis; Epithelial Cells; Fecal Microbiota Transplantation; Female; Homeostasis; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; N-Acetylglucosaminyltransferases; Paneth Cells; Protein Processing, Post-Translational; Pyrans; STAT Transcription Factors; Thiazoles

2018
Acutely elevated O-GlcNAcylation suppresses hippocampal activity by modulating both intrinsic and synaptic excitability factors.
    Scientific reports, 2019, 05-13, Volume: 9, Issue:1

    Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; CA1 Region, Hippocampal; Cells, Cultured; Cognitive Dysfunction; Excitatory Postsynaptic Potentials; Humans; Intravital Microscopy; Male; Memory Disorders; Mice; Models, Animal; N-Acetylglucosaminyltransferases; Neurons; Optical Imaging; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Primary Cell Culture; Protein Processing, Post-Translational; Pyrans; Rats; Receptors, AMPA; Synapses; Thiazoles; Voltage-Gated Sodium Channels

2019
Evidence of a compensatory regulation of colonic O-GlcNAc transferase and O-GlcNAcase expression in response to disruption of O-GlcNAc homeostasis.
    Biochemical and biophysical research communications, 2020, 01-01, Volume: 521, Issue:1

    Topics: Acetylglucosamine; Animals; beta-N-Acetylhexosaminidases; Colon; HCT116 Cells; Homeostasis; Humans; Male; Mice; Mice, Inbred C57BL; N-Acetylglucosaminyltransferases; Pyrans; Thiazoles; Tumor Cells, Cultured

2020
NAG-thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β-N-Acetylglucosaminidase.
    The FEBS journal, 2020, Volume: 287, Issue:22

    Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Bacterial Infections; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Humans; Inhibitory Concentration 50; Kinetics; Models, Molecular; Oligosaccharides; Protein Domains; Substrate Specificity; Thermodynamics; Thiazoles; Vibrio

2020
OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer's Disease Cytoplasmic Hybrids.
    Journal of Alzheimer's disease : JAD, 2020, Volume: 78, Issue:4

    Topics: Acetylation; Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Respiration; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Hybrid Cells; In Vitro Techniques; Male; Mitochondria; Neurons; Pyrans; Sirtuin 3; Stress, Physiological; Thiazoles

2020
In-silico screening and microsecond molecular dynamics simulations to identify single point mutations that destabilize β-hexosaminidase A causing Tay-Sachs disease.
    Proteins, 2021, Volume: 89, Issue:11

    Topics: Acetylglucosamine; beta-Hexosaminidase alpha Chain; Binding Sites; Central Nervous System; G(M2) Ganglioside; Gene Expression; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Neurons; Peripheral Nervous System; Point Mutation; Polymorphism, Single Nucleotide; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Tay-Sachs Disease; Thermodynamics; Thiazoles

2021