acetylgalactosamine has been researched along with oligonucleotides in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 9 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Ishihara, K; Kato, S; Nakanishi, Y; Suzuki, S; Tomiya, N; Tsuji, M | 1 |
| Martin, PT; Porter, BE; Sanes, JR; Scott, LJ | 1 |
| Dowdy, SF; Hamil, AS | 1 |
| Beuers, U; Blem, J; de Vree, JM; Gibson, NW; Grint, P; Grundy, J; Hadi, S; Harbers, M; Huang, M; Kootstra, NA; Liu, K; Molenkamp, R; Neben, S; Patick, AK; Pavlicek, A; Reesink, HW; Rietdijk, S; Schinkel, J; Stelma, F; van der Ree, MH; van der Valk, M; van der Veer, E; van Nuenen, AC; Willemse, S | 1 |
| Brink, A; Husser, C; Koller, E; Müller, MB; Schadt, S; Zell, M | 1 |
| Aparin, IO; Brylev, VA; Farzan, VM; Korshun, VA; Kvach, MV; Majouga, AG; Maklakova, SY; Martynenko-Makaev, YV; Prikazchikova, TA; Shipulin, GA; Shmanai, VV; Ulashchik, EA; Ustinov, AV; Zatsepin, TS | 1 |
| Akinc, A; Brown, CR; Castoreno, A; Degaonkar, R; Gupta, S; Jadhav, V; Maier, MA; Manoharan, M; Matsuda, S; Qin, J; Rajeev, KG; Schlegel, MK; Shulga-Morskaya, S; Waldron, S; Xu, H; Zlatev, I | 1 |
| Becker, G; Graeser, KA; Hoernschemeyer, J; Poecheim, J; Printz, M; Storch, K | 1 |
| Armstrong, J; Butora, G; Copeland, G; Davies, IW; Gouker, J; Jadhav, V; Li, Z; Sherer, EC; Sidler, DR; Tellers, DM; Zewge, D | 1 |
| Jackson, M; Kinberger, GA; Low, A; Prakash, TP; Rigo, F; Seth, PP; Swayze, EE; Yu, J | 1 |
| Aluri, K; Chong, S; Clausen, V; Dennin, S; Gu, Y; Iqbal, S; Jiang, J; Kim, J; Ramsden, D; Wu, JT; Zerler, B | 1 |
| Harada-Shiba, M; Kashiwada, K; Obika, S; Terada, C; Yamamoto, T; Yamayoshi, A | 1 |
| Banyai, T; Campbell, F; Chen, S; Dalekos, GN; Deeg, M; Deng, Y; Goulis, I; Hamatake, R; Han, K; Horvath, G; Huang, M; Jilma, B; Lahiri, S; Leivers, M; Manolakopoulos, S; Papatheodoridis, G; Theodore, D | 1 |
| Blakey, D; Catley, M; Debacker, AJ; Habib, N; Voutila, J | 1 |
| Buatois, S; Chan, HL; Cheng, W; Das, S; Gane, E; Grippo, JF; Hu, TH; Kazma, R; Kim, DJ; Kim, HJ; Kim, W; Krippendorff, BF; Leerapun, A; Lemenuel-Diot, A; Lim, TH; Lim, YS; Mueller, H; Pavlovic, V; Surujbally, B; Tanwandee, T; Triyatni, M; Wat, C; Yuen, MF; Zhang, Y | 1 |
| Chen, S; Cullis, PR; Kulkarni, JA; Leavitt, BR; Thomson, SB; van der Meel, R; Witzigmann, D | 1 |
| Braendli-Baiocco, A; Brink, A; Dzygiel, P; Festag, M; Fischer, G; Hetzel, U; Husser, C; Kipar, A; Koller, E; Lenz, B; Mihatsch, MJ; Romero-Palomo, F; Schadt, S; Sewing, S; Steinhuber, B; Tessier, Y; Winter, M | 1 |
| Biessen, EAL; Van Berkel, TJC | 1 |
| Barnhart, W; Kazarian, AA; Long, J; Murray, JK; Sham, K; Wu, B | 1 |
| Clua, A; Erande, N; Eritja, R; Gargallo, R; Grijalvo, S; Gupta, S; Manoharan, M; Mazzini, S; Yucius, K | 1 |
| Dahlén, A; Elebring, M; Li, XQ; Weidolf, L | 1 |
3 review(s) available for acetylgalactosamine and oligonucleotides
| Article | Year |
|---|---|
Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug.
Topics: Acetylgalactosamine; Animals; Drug Carriers; Drug Delivery Systems; Drug Development; Drug Evaluation, Preclinical; Gene Transfer Techniques; Genetic Therapy; Hepatocytes; Humans; Liver; Oligonucleotides; Research; RNA, Messenger; RNA, Small Interfering; Translational Research, Biomedical | 2020 |
The current landscape of nucleic acid therapeutics.
Topics: Acetylgalactosamine; Gene Editing; Gene Expression Regulation; Genetic Vectors; Humans; Lipids; Nanoparticles; Nucleic Acids; Oligonucleotides; Oligonucleotides, Antisense; Pyrrolidines; RNA, Small Interfering | 2021 |
N-Acetyl Galactosamine Targeting: Paving the Way for Clinical Application of Nucleotide Medicines in Cardiovascular Diseases.
Topics: Acetylgalactosamine; Cardiovascular Diseases; Drug Delivery Systems; Genetic Therapy; Hepatocytes; Humans; Liver; Oligonucleotides; RNAi Therapeutics | 2021 |
3 trial(s) available for acetylgalactosamine and oligonucleotides
| Article | Year |
|---|---|
Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial.
Topics: Acetylgalactosamine; Cohort Studies; Double-Blind Method; Female; Hepatitis C, Chronic; Humans; Injections, Subcutaneous; Male; MicroRNAs; Middle Aged; Oligonucleotides; Viral Load | 2017 |
Randomized clinical trials towards a single-visit cure for chronic hepatitis C: Oral GSK2878175 and injectable RG-101 in chronic hepatitis C patients and long-acting injectable GSK2878175 in healthy participants.
Topics: Acetylgalactosamine; Adult; Antiviral Agents; Benzofurans; Double-Blind Method; Healthy Volunteers; Hepatitis C, Chronic; Humans; Male; Oligonucleotides; Treatment Outcome | 2020 |
Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B.
Topics: Acetylgalactosamine; Adult; Asialoglycoprotein Receptor; Female; Healthy Volunteers; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Oligonucleotides; Oligonucleotides, Antisense; RNA, Viral; Sustained Virologic Response | 2021 |
15 other study(ies) available for acetylgalactosamine and oligonucleotides
| Article | Year |
|---|---|
Hydrolysis of sugar nucleotides in chicken egg white in response to embryonic development.
Topics: Acetylgalactosamine; Animals; Blastoderm; Chick Embryo; Chickens; Egg White; Female; Fertilization; Guanosine Diphosphate Mannose; Nucleoside Diphosphate Sugars; Oligonucleotides; Pyrophosphatases; Uridine Diphosphate N-Acetylgalactosamine | 1978 |
Distinct structures and functions of related pre- and postsynaptic carbohydrates at the mammalian neuromuscular junction.
Topics: Acetylgalactosamine; Animals; Antibodies, Monoclonal; Cell Adhesion; Cells, Cultured; Epitopes; Glycolipids; Glycoproteins; Laminin; Lectins; Motor Endplate; Motor Neurons; Muscle Development; Muscle Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Oligonucleotides; Rats; Receptors, Presynaptic; Structure-Activity Relationship | 1999 |
Synthesis and Conjugation of Small Interfering Ribonucleic Neutral SiRNNs.
Topics: Acetylgalactosamine; Animals; Chemistry Techniques, Synthetic; Gene Knockdown Techniques; Mice; Oligonucleotides; Prodrugs; RNA, Small Interfering | 2016 |
Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry.
Topics: Acetylgalactosamine; Animals; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Hepatocytes; Male; Mass Spectrometry; Oligonucleotides; Oligonucleotides, Antisense; Rats; Rats, Wistar; Solid Phase Extraction | 2017 |
Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters.
Topics: Acetylgalactosamine; Alkynes; Automation; Azides; Click Chemistry; Cycloaddition Reaction; Oligonucleotides; Solid-Phase Synthesis Techniques | 2017 |
Reversal of siRNA-mediated gene silencing in vivo.
Topics: Acetylgalactosamine; Animals; Base Sequence; Biotechnology; Cells, Cultured; Female; Gene Silencing; Hepatocytes; Humans; Ligands; Mice; Mice, Inbred C57BL; Oligonucleotides; RNA Interference; RNA, Small Interfering | 2018 |
Development of stable liquid formulations for oligonucleotides.
Topics: Acetylgalactosamine; Drug Carriers; Drug Compounding; Drug Stability; Excipients; Gamma Rays; Hydrogen-Ion Concentration; Oligonucleotides; Solutions; Sterilization | 2018 |
Post-Synthetic Modification of Oligonucleotides via Orthogonal Amidation and Copper Catalyzed Cycloaddition Reactions.
Topics: Acetylgalactosamine; Amides; Azides; Catalysis; Click Chemistry; Copper; Cycloaddition Reaction; Esterification; HeLa Cells; Humans; Models, Molecular; Oligonucleotides; RNA, Small Interfering; Triazoles | 2018 |
Evaluation of the effect of 2'-O-methyl, fluoro hexitol, bicyclo and Morpholino nucleic acid modifications on potency of GalNAc conjugated antisense oligonucleotides in mice.
Topics: Acetylgalactosamine; Animals; Asialoglycoprotein Receptor; Halogenation; Hepatocytes; Methylation; Mice; Mice, Inbred C57BL; Models, Molecular; Morpholinos; Oligonucleotides; Oligonucleotides, Antisense; Sugar Alcohols; Survival of Motor Neuron 2 Protein | 2018 |
In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.
Topics: Acetylgalactosamine; Cells, Cultured; Computer Simulation; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Assays; Hepatocytes; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Models, Biological; Oligonucleotides; Recombinant Proteins; RNA, Small Interfering | 2019 |
Synthesis of Monovalent N-Acetylgalactosamine Phosphoramidite for Liver-Targeting Oligonucleotides.
Topics: Acetylgalactosamine; Drug Delivery Systems; Ligands; Liver; Oligonucleotides; Organophosphorus Compounds | 2019 |
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.
Topics: Acetylgalactosamine; Animals; Male; Oligonucleotides; Oligonucleotides, Antisense; Rats; Tissue Distribution | 2021 |
Purification of N-acetylgalactosamine-modified-oligonucleotides using orthogonal anion-exchange and mixed-mode chromatography approaches.
Topics: Acetylgalactosamine; Anions; Chromatography, Ion Exchange; Oligonucleotides | 2022 |
Properties of Parallel Tetramolecular G-Quadruplex Carrying
Topics: Acetylgalactosamine; Asialoglycoprotein Receptor; G-Quadruplexes; HeLa Cells; Hepatocytes; Humans; Oligonucleotides | 2022 |
In Vivo Metabolite Profiles of an
Topics: Acetylgalactosamine; Animals; Chromatography, Liquid; Humans; Mass Spectrometry; Mice; Oligonucleotides; Oligonucleotides, Antisense; Rabbits; Rats | 2023 |