acetylcysteine and verapamil

acetylcysteine has been researched along with verapamil in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's4 (17.39)18.2507
2000's10 (43.48)29.6817
2010's7 (30.43)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, S; Gao, W; Gao, YX; Liao, H; Pang, T; Qiu, WW; Wang, YJ; Wang, YY; Xu, Y; Xu, YZ; Yang, LF; Yu, LG; Zhang, LY1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cho, CH; Koo, MW; Ogle, CW1
Finkel, MS; Oddis, CV; Romeo, RC; Salama, G; Shen, L1
Bowers, JL; Clouse, ME; Cook, CU; Neymark, E1
Andersson, R; Deng, XM; Haraldsen, P; Ihse, I; Wang, XD1
Allouche, M; Bailly, JD; Bordier, C; Come, MG; Duchayne, E; Laurent, G; Mansat, V; Quillet-Mary, A1
Das, M; Mukherjee, SB; Shaha, C; Sudhandiran, G1
Borm, PJ; Brown, DM; Dehnhardt, M; Donaldson, K; Gilmour, P; Jimenez, LA; Schins, RP; Stone, V1
Feril, LB; Honda, H; Kitagawa, H; Kondo, T; Zhao, QL1
Chakrabarti, SK; Lemieux, N; M'Bemba-Meka, P1
Foth, H; Glahn, F; Stehfest, E; Torky, A1
Frumin, I; Iancu, TC; Manov, I; Motanis, H1
Bernkop-Schnürch, A; Hombach, J; Hoyer, H1
Bhat, MK; Chaube, B; Pandey, V1
Nikiteas, N; Perrea, D; Tsigris, C; Yiannakopoulou, E1
Banks, WA; Erickson, MA; Hansen, K1
Dou, QP; Huang, H; Li, X; Liu, J; Liu, N; Liu, S; Yang, C1
Gu, Q; Kanungo, J; Robinson, B; Rodgers, J1

Reviews

3 review(s) available for acetylcysteine and verapamil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Hepatotoxicity of anti-inflammatory and analgesic drugs: ultrastructural aspects.
    Acta pharmacologica Sinica, 2006, Volume: 27, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Drug Overdose; Hepatocytes; Humans; Liver; Liver Diseases; Liver Neoplasms; Verapamil

2006
Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review.
    Surgical laparoscopy, endoscopy & percutaneous techniques, 2012, Volume: 22, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Erythromycin; Humans; Laparoscopy; Melatonin; Mesna; Oxidative Stress; Pentoxifylline; Pneumoperitoneum, Artificial; Rabbits; Rats; Verapamil; Zinc Compounds

2012

Other Studies

20 other study(ies) available for acetylcysteine and verapamil

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Animals; Brain Injuries; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Design; Glutamic Acid; Molecular Structure; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2015
Effects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats.
    Pharmacology, 1986, Volume: 32, Issue:6

    Topics: Acetylcysteine; Animals; Carbenoxolone; Cold Temperature; Drug Administration Schedule; Female; Gastric Mucosa; Glycyrrhetinic Acid; Mucus; Rats; Rats, Inbred Strains; Restraint, Physical; Stomach Ulcer; Stress, Physiological; Verapamil

1986
Positive inotropic effect of acetylcysteine in cardiomyopathic Syrian hamsters.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:1

    Topics: Acetylcysteine; Analysis of Variance; Animals; Cardiomyopathies; Cricetinae; Cysteine; Cystine; Male; Mesocricetus; Myocardial Contraction; Papillary Muscles; Ryanodine; Stimulation, Chemical; Verapamil

1993
31P nuclear magnetic resonance spectroscopic evaluation of liver preservation solutions.
    Transplantation, 1994, Jun-15, Volume: 57, Issue:11

    Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Antioxidants; Chromans; Glutathione; Insulin; Liver; Magnetic Resonance Spectroscopy; Male; Nucleotides; Organ Preservation; Organ Preservation Solutions; Perfusion; Raffinose; Rats; Rats, Sprague-Dawley; Verapamil

1994
Antioxidant and calcium channel blockers counteract endothelial barrier injury induced by acute pancreatitis in rats.
    Scandinavian journal of gastroenterology, 1995, Volume: 30, Issue:11

    Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Calcium; Calcium Channel Blockers; Diltiazem; Endothelium; Free Radicals; Gastrointestinal Motility; Male; Pancreatitis; Permeability; Rats; Rats, Sprague-Dawley; Serum Albumin, Radio-Iodinated; Verapamil

1995
Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.
    Leukemia, 1996, Volume: 10, Issue:3

    Topics: Acetylcysteine; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Differentiation; Daunorubicin; DNA Damage; DNA Nucleotidylexotransferase; DNA, Neoplasm; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Methionine Sulfoximine; Nucleosomes; Pyrrolidines; Thiocarbamates; Tumor Cells, Cultured; Verapamil

1996
Increase in cytosolic Ca2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes.
    The Journal of biological chemistry, 2002, Jul-05, Volume: 277, Issue:27

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Apoptosis; Cations; Cell Death; Cytosol; Egtazic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Leishmania donovani; Mitochondria; Oxidative Stress; Potassium; Reactive Oxygen Species; Ruthenium Red; Sodium; Verapamil

2002
Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:2

    Topics: Acetylcysteine; Air Pollutants; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Carbon; Chelating Agents; Egtazic Acid; Gene Expression; Lysine; Macrophages, Alveolar; Male; Particle Size; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Verapamil

2004
Role of intracellular calcium ions and reactive oxygen species in apoptosis induced by ultrasound.
    Ultrasound in medicine & biology, 2004, Volume: 30, Issue:5

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Calcium; Calcium Channel Blockers; Caspase 3; Caspases; Chelating Agents; Contrast Media; DNA, Neoplasm; Egtazic Acid; Flow Cytometry; Glutathione; Humans; Membrane Potentials; Microscopy, Electron; Mitochondria; Polysaccharides; Reactive Oxygen Species; U937 Cells; Ultrasonics; Verapamil

2004
Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: role of oxidative stress and intracellular calcium.
    Mutation research, 2005, Oct-03, Volume: 586, Issue:2

    Topics: Acetylcysteine; Analysis of Variance; Calcium; Catalase; Chromatin; Cytogenetic Analysis; Dantrolene; Deferoxamine; DNA Damage; Egtazic Acid; Humans; In Situ Nick-End Labeling; Lymphocytes; Microscopy, Electron; Mutagenicity Tests; Nickel; Oxidative Stress; Superoxide Dismutase; Thiourea; Verapamil

2005
Non-destructive micromethod for MRP1 functional assay in human lung tumor cells.
    Archives of toxicology, 2006, Volume: 80, Issue:3

    Topics: Acetylcysteine; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Buthionine Sulfoximine; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Fluorometry; Glutathione; Humans; Immunohistochemistry; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Sensitivity and Specificity; Verapamil

2006
Thiolated chitosans: development and in vitro evaluation of an oral tobramycin sulphate delivery system.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2008, Volume: 33, Issue:1

    Topics: Acetylcysteine; Administration, Oral; Animals; Biological Transport; Caco-2 Cells; Chitosan; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Epithelial Cells; Glutathione; Humans; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Tablets; Technology, Pharmaceutical; Tobramycin; Verapamil

2008
Hyperglycemia regulates MDR-1, drug accumulation and ROS levels causing increased toxicity of carboplatin and 5-fluorouracil in MCF-7 cells.
    Journal of cellular biochemistry, 2011, Volume: 112, Issue:10

    Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Female; Fluorouracil; Glucose; Humans; Hyperglycemia; Inhibitory Concentration 50; NF-kappa B; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Verapamil

2011
Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-acetylcysteine.
    Brain, behavior, and immunity, 2012, Volume: 26, Issue:7

    Topics: Acetylcysteine; Algorithms; alpha-Macroglobulins; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Calcium Channel Blockers; Cerebral Cortex; Chemokines; Cytokines; Glutathione; Hippocampus; Inflammation; Lipopolysaccharides; Low Density Lipoprotein Receptor-Related Protein-1; Male; Mice; Oxidative Stress; Protein Carbonylation; Receptors, LDL; Serum Albumin; Tumor Suppressor Proteins; Verapamil

2012
Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation.
    Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Calcium Channel Blockers; Caspases; Cell Death; Drug Synergism; Endoplasmic Reticulum Stress; Hep G2 Cells; Humans; K562 Cells; Proteasome Inhibitors; Reactive Oxygen Species; Verapamil; Xanthones

2014
N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2020, Volume: 144

    Topics: Acetylcysteine; Animals; Antioxidants; Calcium Channel Blockers; Cardiotoxicity; Cysteine; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Heart Rate; Verapamil; Zebrafish

2020