Compounds > acetylcysteine

acetylcysteine and troglitazone

acetylcysteine has been researched along with troglitazone in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (50.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Hanada, S; Harada, M; Koga, H; Kumashiro, R; Kumemura, H; Namba, M; Ohira, H; Sata, M; Sato, Y; Shishido, S; Taniguchi, E; Ueno, T1
Bharadwaj, LA; Davies, GF; Ovsenek, N; Roesler, WJ1
Alba, G; Alvarez-Maqueda, M; Bedoya, FJ; Chacón, P; El Bekay, R; Martín-Nieto, J; Monteseirín, J; Pintado, E; Sobrino, F; Vega, A1
Grönberg, G; Hansen, SH; Jurva, U; Madsen, KG; Olsen, J; Skonberg, C1
Li, C; Li, L; Liu, X; Yang, L; Yu, H1

Reviews

1 review(s) available for acetylcysteine and troglitazone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

9 other study(ies) available for acetylcysteine and troglitazone

ArticleYear
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes.
    Hepatology (Baltimore, Md.), 2003, Volume: 37, Issue:1

    Topics: Acetylcysteine; Albumins; Antioxidants; Cell Line, Transformed; Cell Polarity; Chromans; Cytochrome c Group; Free Radical Scavengers; Hepatocytes; Humans; Hydrogen Peroxide; Ligands; Microscopy, Electron; Mitochondria; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone

2003
Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism.
    Pharmacological research, 2003, Volume: 48, Issue:1

    Topics: Acetylcysteine; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gene Expression; Heat-Shock Proteins; Hepatocytes; Histones; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazolidinediones; Troglitazone; Ubiquitin

2003
15-deoxy-delta 12,14-prostaglandin J2 induces heme oxygenase-1 gene expression in a reactive oxygen species-dependent manner in human lymphocytes.
    The Journal of biological chemistry, 2004, May-21, Volume: 279, Issue:21

    Topics: Acetylcysteine; Allopurinol; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Chromans; Cyclic N-Oxides; Cyclopentanes; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Ions; Lymphocytes; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthrolines; Phosphatidylinositol 3-Kinases; Prostaglandin D2; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Temperature; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Xanthine Oxidase

2004
Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.
    Chemical research in toxicology, 2008, Volume: 21, Issue:10

    Topics: Acetylcysteine; Animals; Chromans; Electrochemistry; Humans; Magnetic Resonance Spectroscopy; Microsomes, Liver; Molecular Structure; Oxidation-Reduction; Pioglitazone; Rats; Rosiglitazone; Thiazolidinediones; Troglitazone

2008
15-Deoxy-Δ(12,14)-prostaglandin J(2) attenuates the biological activities of monocyte/macrophage cell lines.
    European journal of cell biology, 2012, Volume: 91, Issue:8

    Topics: Acetylcysteine; Anilides; Animals; Cell Line; Cell Proliferation; Chemokine CCL2; Chromans; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Monocytes; Oxidative Stress; Phagocytosis; PPAR gamma; Prostaglandin D2; Reactive Oxygen Species; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha

2012