acetylcysteine has been researched along with transforming growth factor beta in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (18.87) | 18.2507 |
| 2000's | 26 (49.06) | 29.6817 |
| 2010's | 13 (24.53) | 24.3611 |
| 2020's | 4 (7.55) | 2.80 |
| Authors | Studies |
|---|---|
| Das, SK; Fanburg, BL; White, AC | 1 |
| Satriano, J; Schlondorff, D; Shan, Z; Silbiger, S; Tan, D | 1 |
| Kuroki, T; Nose, K; Ohba, M; Shibanuma, M | 1 |
| Bauer, G; Jürgensmeier, JM; Langer, C | 1 |
| Gupta, A; Huang, A; Ji, Z; Monroy, D; Pflugfelder, SC; Yoshino, K | 1 |
| Guerrin, M; Lafon, C; Mathieu, C; Pierre, O; Valette, A; Vidal, S | 1 |
| Craven, PA; DeRubertis, FR; Studer, RK | 1 |
| Chou, CK; Huang, YL; Hwang, KC; Luh, TY; Shen, CK; Yang, HC | 1 |
| Fanburg, BL; Lanzillo, JJ; Lee, SL; Maloney, EK; White, AC | 1 |
| De Bleser, PJ; Geerts, A; Rogiers, V; Rombouts, K; Xu, G | 1 |
| Abe, S; Kudoh, S; Sugawara, I; Takizawa, H | 1 |
| Barbieri, D; Kletsas, D; Malagoli, D; Ottaviani, E | 1 |
| Choi, HJ; Han, HJ; Kim, JH; Lee, JH; Park, SH; Woo, CH | 1 |
| Drahushuk, KM; Guo, X; Higgins, D; Horbinski, C; Kaplan, PL; Kim, IJ; Lein, P; Lin, Y; Wang, T | 1 |
| Bassus, S; Bremerich, D; Busse, R; Görlach, A; Herkert, O; Kirchmaier, CM; Kronemann, N; Schini-Kerth, VB | 1 |
| Choi, Y; Chung, WJ; Kim, HH; Kim, MS; Kim, SW; Kwack, K; Lee, SE; Lee, ZH; Park, H | 1 |
| Ayache, N; Boumediene, K; Henrotin, Y; Mathy-Hartert, M; Pujol, JP; Reginster, JY | 1 |
| Buch, D; Decup, F; Goldberg, M; Lasfargues, JJ; Salih, E; Six, N; Soheili Majd, E; Stanislawski, L | 1 |
| Fujimiya, T; Naito, K; Shiraishi, K; Yoshida, K | 1 |
| Bengtsson, T; Berg, C; Trofast, C | 1 |
| Dehnade, F; Li, WQ; Liacini, A; Qureshi, HY; Zafarullah, M | 1 |
| Higgins, D; Horbinski, C; Kim, WY; Sigurdson, W | 1 |
| Aoki, Y; Kanai, H; Kawai-Kowase, K; Kurabayashi, M; Maeno, T; Nagai, R; Ohyama, Y; Oyama, Y; Sakamoto, H; Sato, H; Sato, M; Suga, T; Tamura, J | 1 |
| Dambach, DM; Durham, SK; Laskin, DL; Laskin, JD | 1 |
| Gressner, AM; Lahme, B; Meurer, SK; Tihaa, L; Weiskirchen, R | 1 |
| Chen, Y; Fürst, D; Jesnowski, R; Kleeff, J; Kolb, A; Löhr, M; Ringel, J; Schareck, WD; Schrödel, A | 1 |
| Koch, RJ; Kunnavatana, SS; Quan, SY | 1 |
| Borkham-Kamphorst, E; Gressner, AM; Meurer, SK; Weiskirchen, R | 1 |
| Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
| Hosler, MR; Wagner, BJ; Wang-Su, ST | 1 |
| Alili, L; Brenneisen, P; Cat, B; Holtkötter, O; Sies, H; Steinbrenner, H; Stuhlmann, D | 1 |
| Li, ZH; Ma, X; Meng, H; Shu, Z; Zhang, BX; Zhang, W | 1 |
| Ahn, HJ; Huh, KH; Ju, MK; Kim, MS; Kim, SI; Kim, YS; Park, J; Song, JS | 1 |
| Ayala, A; Cadacio, C; D'Aquino-Ardalan, C; Evans, B; Ganapathy, V; Gold, LI; Lecanda, J | 1 |
| Galicia-Moreno, M; Moreno, MG; Muriel, P; Reyes-Gordillo, K; Rodríguez-Rivera, A; Segovia, J; Shibayama, M; Tsutsumi, V; Vergara, P | 1 |
| Hu, JM; Zhong, NS | 1 |
| Chernyak, BV; Domnina, LV; Dugina, VB; Ivanova, OY; Izyumov, DS; Pletjushkina, OY; Popova, EN; Skulachev, VP | 1 |
| Haller, E; Mills, GB; Nanjundan, M; Patel, S; Raffoul, F; Smith, DM | 1 |
| Hamatani, H; Hiromura, K; Kuroiwa, T; Maeshima, A; Nojima, Y; Sakairi, T; Takahashi, S; Takeuchi, S; Tomioka, M | 1 |
| Adamali, HI; Maher, TM | 1 |
| Boesch-Saadatmandi, C; Ciesla, M; Dulak, J; Jozkowicz, A; Kozakowska, M; Loboda, A; Rimbach, G; Stachurska, A; Wolffram, S | 1 |
| Kao, SC; Kau, HC; Lee, FL; Tsai, CC; Wei, YH; Wu, SB | 1 |
| Broumand, MA; Darabi, F; Jenab, Y; Khalili, H; Salarifar, M; Talasaz, AH | 1 |
| Arellanes-Robledo, J; Hernández-Nazara, Z; Inagaki, Y; Lakshman, MR; Reyes-Gordillo, K; Rincón-Sánchez, AR; Rojkind, M; Shah, R | 1 |
| Cingi, C; Dündar, R; İlknur, AE; İnan, S; Katılmış, H; Muluk, NB | 1 |
| Sun, Y; Wei, Z; Yang, F; Zhao, L | 1 |
| Fujita, T; Kajiya, M; Kurihara, H; Matsuda, S; Ouhara, K; Shiba, H; Yoshimoto, T | 1 |
| Bai, D; Gao, Y; Ge, L; Lu, X; Wang, H; Yang, G | 1 |
| Bayat, Z; Kadioglu, E; Ozatik, FY; Ozatik, O; Teksen, Y | 1 |
| Cen, X; Chen, A; Chen, W; Cheng, M; Guo, Y; He, H; Li, W; Ma, J; Mu, G; Qiu, W; Wang, B; Wang, D; Wang, X; Xiao, L; Yang, M; Yang, S; Zhang, X; Zhou, M; Zhou, Y; Zhu, C | 1 |
| Dey, AB; Kandel, R; Mitra, DK; Mohan, A; Namdeo, M; Thakur, PK | 1 |
| Awasthi, S; Garg, R; Horne, D; Salgia, R; Singhal, S; Singhal, SS | 1 |
| Chuang, HC; Hsu, YC; Kuo, CH; Lin, CL; Liu, YF; Shih, SS; Shyong, YJ; Tsai, KL; Tu, TY | 1 |
2 review(s) available for acetylcysteine and transforming growth factor beta
| Article | Year |
|---|---|
Current and novel drug therapies for idiopathic pulmonary fibrosis.
Topics: Acetylcysteine; Amino Acid Oxidoreductases; Animals; Antiviral Agents; Gastroesophageal Reflux; Humans; Idiopathic Pulmonary Fibrosis; Interleukin-13; Lung Transplantation; MicroRNAs; Protein Kinase Inhibitors; Pyridones; Transforming Growth Factor beta | 2012 |
RLIP: A necessary transporter protein for translating oxidative stress into pro-obesity and pro-carcinogenic signaling.
Topics: Acetylcysteine; Adipokines; Animals; Carcinogenesis; Carcinogens; Carrier Proteins; Clathrin; Cytokines; Epidermal Growth Factor; GTPase-Activating Proteins; Humans; Infant; Insulins; Male; Mice; Neoplasms; Obesity; Oxidative Stress; Peptide Hormones; Transforming Growth Factor beta; Tumor Suppressor Protein p53 | 2022 |
1 trial(s) available for acetylcysteine and transforming growth factor beta
| Article | Year |
|---|---|
N-Acetylcysteine effects on transforming growth factor-β and tumor necrosis factor-α serum levels as pro-fibrotic and inflammatory biomarkers in patients following ST-segment elevation myocardial infarction.
Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Aged, 80 and over; Biomarkers; Double-Blind Method; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Fibrosis; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Transforming Growth Factor beta; Treatment Outcome; Tumor Necrosis Factor-alpha | 2013 |
50 other study(ies) available for acetylcysteine and transforming growth factor beta
| Article | Year |
|---|---|
Modulation of transforming growth factor-beta 1 antiproliferative effects on endothelial cells by cysteine, cystine, and N-acetylcysteine.
Topics: Acetylcysteine; Animals; Cattle; Cell Division; Cells, Cultured; Cysteine; Cystine; Endothelium, Vascular; Glutathione; Transforming Growth Factor beta; Tumor Cells, Cultured | 1992 |
Intracellular glutathione influences collagen generation by mesangial cells.
Topics: Acetylcysteine; Animals; Antimetabolites; Buthionine Sulfoximine; Cell Transformation, Viral; Cells, Cultured; Collagen; Culture Media; Glomerular Mesangium; Glucose; Glutathione; Methionine Sulfoximine; Mice; Oxidation-Reduction; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta | 1994 |
Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.
Topics: 3T3 Cells; Acetylcysteine; Animals; Base Sequence; Catalase; Cell Line, Transformed; Cell Nucleus; Chloramphenicol O-Acetyltransferase; DNA-Binding Proteins; Early Growth Response Protein 1; Free Radical Scavengers; Gene Expression; Genes, ras; Humans; Hydrogen Peroxide; Immediate-Early Proteins; Mice; Molecular Sequence Data; Osteoblasts; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Zinc Fingers | 1994 |
Reactive oxygen species act at both TGF-beta-dependent and -independent steps during induction of apoptosis of transformed cells by normal cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Catechols; Cell Line; Cell Line, Transformed; Clone Cells; Coculture Techniques; Dimethyl Sulfoxide; Fibroblasts; Free Radical Scavengers; Glutathione; Mice; Reactive Oxygen Species; Transforming Growth Factor beta | 1996 |
Transforming growth factor beta-1 and beta-2 in human tear fluid.
Topics: Acetylcysteine; Adult; Animals; Biological Assay; Blotting, Western; Cell Line; Enzyme-Linked Immunosorbent Assay; Humans; In Vitro Techniques; Lactoferrin; Male; Mink; Neutralization Tests; Peptide Fragments; Protein Precursors; Proteins; Recombinant Proteins; Tears; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 1996 |
Transforming growth factor beta 1-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2.
Topics: Acetylcysteine; Adenocarcinoma; Apoptosis; Blotting, Northern; Blotting, Western; Cell Division; DNA Fragmentation; Female; Genes, fos; Genes, jun; Humans; Hydrogen Peroxide; Ovarian Neoplasms; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Time Factors; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 1996 |
Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcysteine; Angiotensin II; Animals; Antioxidants; Cells, Cultured; Enzyme Activation; Female; Glucose; Kidney Glomerulus; Phorbol 12,13-Dibutyrate; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Taurine; Thromboxane A2; Thromboxanes; Transforming Growth Factor beta; Vitamin E | 1997 |
Blockage of apoptotic signaling of transforming growth factor-beta in human hepatoma cells by carboxyfullerene.
Topics: Acetylcysteine; Apoptosis; Ascorbic Acid; Carbon; Carboxylic Acids; Carcinoma, Hepatocellular; Cell Survival; Flow Cytometry; Fluorescent Dyes; Free Radical Scavengers; Fullerenes; Humans; Liposomes; Molecular Structure; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Reactive Oxygen Species; Signal Transduction; Stereoisomerism; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Reduction of endothelial cell related TGFbeta activity by thiols.
Topics: Acetylcysteine; Animals; Cattle; Cells, Cultured; Culture Media, Conditioned; Cysteine; Dose-Response Relationship, Drug; Endothelium, Vascular; Glutathione; Glutathione Disulfide; Oxidation-Reduction; Pulmonary Artery; Sulfhydryl Compounds; Swine; Transforming Growth Factor beta | 1999 |
Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells.
Topics: Acetylcysteine; Animals; Blotting, Northern; Carbon Tetrachloride; Catalase; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Superoxide Dismutase; Transforming Growth Factor beta; Vitamin K | 1999 |
Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitro.
Topics: Acetylcysteine; Antioxidants; Bronchi; Cell Line, Transformed; Epithelial Cells; Free Radical Scavengers; Gene Expression; Humans; In Vitro Techniques; Interleukin-8; Pyrrolidines; RNA, Messenger; Thiocarbamates; Thymidine; Transforming Growth Factor beta; Tritium; Vehicle Emissions | 2000 |
Involvement of PI 3-kinase, PKA and PKC in PDGF- and TGF-beta-mediated prevention of 2-deoxy-D-ribose-induced apoptosis in the insect cell line, IPLB-LdFB.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Line; Cyclic AMP-Dependent Protein Kinases; Deoxyribose; Enzyme Activation; Membrane Potentials; Mitochondria; Moths; Oxidative Stress; Phosphatidylinositol 3-Kinases; Platelet-Derived Growth Factor; Protein Kinase C; Transforming Growth Factor beta | 2001 |
High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Cycle; Cell Division; Cells, Cultured; Diabetic Nephropathies; Glucose; Kidney Tubules, Proximal; Leucine; Lipid Peroxides; Oxidative Stress; Protein Kinase C; Rabbits; Taurine; Thymidine; Transforming Growth Factor beta; Vitamin E | 2001 |
Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.
Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendrites; DNA-Binding Proteins; Gene Expression; Leupeptins; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Superior Cervical Ganglion; Trans-Activators; Transcriptional Activation; Transfection; Transforming Growth Factor beta | 2001 |
Thrombin causes vascular endothelial growth factor expression in vascular smooth muscle cells: role of reactive oxygen species.
Topics: Acetylcysteine; Angioplasty, Balloon; Animals; Antioxidants; Arterial Occlusive Diseases; Ascorbic Acid; Cells, Cultured; Endothelial Growth Factors; Fibroblast Growth Factor 2; Humans; Kinetics; Lymphokines; Male; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Thrombin; Transcriptional Activation; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Stabilization of hypoxia-inducible factor-1alpha is involved in the hypoxic stimuli-induced expression of vascular endothelial growth factor in osteoblastic cells.
Topics: Acetylcysteine; Blotting, Western; Calcitriol; Cell Line; Cobalt; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Growth Factors; Free Radical Scavengers; Gene Expression; Glucocorticoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Lymphokines; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
Expression of TGF-betas and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondrocytes.
Topics: Acetylcysteine; Cartilage, Articular; Cells, Cultured; Chondrocytes; Female; Humans; Lipopolysaccharides; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Osteoarthritis, Knee; Reactive Oxygen Species; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta; Up-Regulation | 2002 |
Application of bioactive molecules in pulp-capping situations.
Topics: Acetylcysteine; Animals; Antioxidants; Biocompatible Materials; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Calcium Hydroxide; Dental Pulp; Dental Pulp Capping; Dental Pulp Cavity; Dental Pulp Exposure; Dental Restoration, Permanent; Dentin; Dentin, Secondary; Dentinogenesis; Free Radical Scavengers; Glass Ionomer Cements; Integrin-Binding Sialoprotein; Male; Pharmaceutical Vehicles; Rats; Rats, Sprague-Dawley; Sialoglycoproteins; Time Factors; Transforming Growth Factor beta; Wound Healing | 2001 |
Angiotensin II dependent testicular fibrosis and effects on spermatogenesis after vasectomy in the rat.
Topics: Acetylcysteine; Aldehydes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Enalapril; Fibrosis; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Leydig Cells; Losartan; Male; Rats; Rats, Wistar; Spermatogenesis; Testis; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vasectomy | 2003 |
Platelets induce reactive oxygen species-dependent growth of human skin fibroblasts.
Topics: Acetophenones; Acetylcysteine; Becaplermin; Blood Platelets; Cell Division; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Fluoresceins; Humans; Lysophospholipids; NADPH Oxidases; Onium Compounds; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Reactive Oxygen Species; Skin; Sphingosine; Thiocarbamates; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Azoles; Blotting, Northern; Blotting, Western; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Culture Media, Serum-Free; Cycloheximide; DNA-Binding Proteins; Down-Regulation; Free Radicals; Growth Substances; Humans; Hydrogen Peroxide; Isoindoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Oligonucleotides, Antisense; Organoselenium Compounds; Oxidation-Reduction; Phosphorylation; Reactive Oxygen Species; RNA; RNA, Messenger; Signal Transduction; Smad2 Protein; Species Specificity; Time Factors; Tissue Inhibitor of Metalloproteinase-3; Trans-Activators; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons.
Topics: Acetylcysteine; Animals; Blotting, Western; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Count; Cell Size; Cells, Cultured; Cysteine Proteinase Inhibitors; Dendrites; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Intranuclear Inclusion Bodies; Mutagenesis; Neurons; Peptides; Phthalimides; Rats; Superior Cervical Ganglion; Time Factors; Transfection; Transforming Growth Factor beta | 2004 |
c-Src and hydrogen peroxide mediate transforming growth factor-beta1-induced smooth muscle cell-gene expression in 10T1/2 cells.
Topics: Acetophenones; Acetylcysteine; Animals; Catalase; Cell Line; Ditiocarb; DNA-Binding Proteins; Fibroblasts; Flavonoids; Fluoresceins; Gene Expression Regulation; Gene Targeting; Hydrogen Peroxide; Mice; Mice, Inbred C3H; Microfilament Proteins; Muscle Proteins; NADPH Oxidases; Naphthalenes; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Recombinant Fusion Proteins; Serum Response Factor; Signal Transduction; Smad3 Protein; Smad4 Protein; Smad6 Protein; src-Family Kinases; Sulfones; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Chemokines; Gene Expression; Glutathione; Humans; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-1; Interleukin-10; Interleukin-4; Liver; Macrophage Inflammatory Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Necrosis; NF-kappa B p50 Subunit; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase; Time Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2006 |
N-acetyl-L-cysteine suppresses TGF-beta signaling at distinct molecular steps: the biochemical and biological efficacy of a multifunctional, antifibrotic drug.
Topics: Acetylcysteine; Animals; Blotting, Western; COS Cells; DNA-Binding Proteins; Liver Cirrhosis; Male; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Signal Transduction; Smad7 Protein; Trans-Activators; Transforming Growth Factor beta | 2005 |
Immortalization of pancreatic stellate cells as an in vitro model of pancreatic fibrosis: deactivation is induced by matrigel and N-acetylcysteine.
Topics: Acetylcysteine; Antigens, Polyomavirus Transforming; Biomarkers; Cell Cycle; Cell Line; Cell Proliferation; Collagen; Drug Combinations; Fibrosis; Gene Expression; Humans; Karyotyping; Laminin; Pancreas; Platelet-Derived Growth Factor; Proteoglycans; Telomerase; Transforming Growth Factor beta; Vitamin A | 2005 |
Combined effect of hyberbaric oxygen and N-acetylcysteine on fibroblast proliferation.
Topics: Acetylcysteine; Aged; Cell Line; Cell Proliferation; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Fibroblasts; Humans; Hyperbaric Oxygenation; Male; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A | 2005 |
Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells.
Topics: Acetylcysteine; Animals; Becaplermin; Disulfides; Liver; Male; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta | 2005 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
Role of the proteasome in TGF-beta signaling in lens epithelial cells.
Topics: Acetylcysteine; Actins; Annexins; Blotting, Western; Cataract; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Fibronectins; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutamate-Cysteine Ligase; Humans; Intracellular Signaling Peptides and Proteins; Lens, Crystalline; Leupeptins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transcriptional Activation; Transforming Growth Factor beta | 2006 |
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.
Topics: Acetylcysteine; Antioxidants; Cell Differentiation; Cells, Cultured; Chromans; Disease Progression; Fibroblasts; Humans; Lipid Peroxidation; Models, Biological; Muscle Fibers, Skeletal; Neoplasm Invasiveness; Protein Kinase C; Reactive Oxygen Species; Skin; Smad Proteins; Sodium Selenite; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Regulation of STIM1, store-operated Ca2+ influx, and nitric oxide generation by retinoic acid in rat mesangial cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Bradykinin; Calcium; Calcium Signaling; Cells, Cultured; Cysteine Proteinase Inhibitors; Gene Expression; Glucose; Membrane Glycoproteins; Mesangial Cells; Nitric Oxide; Nitric Oxide Synthase Type III; Proteasome Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stromal Interaction Molecule 1; Transforming Growth Factor beta; Tretinoin | 2007 |
Mycophenolic acid inhibits oleic acid-induced mesangial cell activation through both cellular reactive oxygen species and inosine monophosphate dehydrogenase 2 pathways.
Topics: Acetylcysteine; Animals; Antibodies, Blocking; Cells, Cultured; Culture Media, Conditioned; Drug Antagonism; Enzyme Inhibitors; Fibronectins; Guanosine; IMP Dehydrogenase; Mesangial Cells; Mice; Mice, Transgenic; Mycophenolic Acid; Oleic Acid; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Transforming Growth Factor beta | 2009 |
TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest.
Topics: Acetylcysteine; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; Humans; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; RNA, Small Interfering; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2009 |
N-acetylcysteine prevents carbon tetrachloride-induced liver cirrhosis: role of liver transforming growth factor-beta and oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver Cirrhosis, Experimental; Male; Oxidative Stress; Rats; Rats, Wistar; Transforming Growth Factor beta | 2009 |
[A preliminary study on the mechanisms of N-acetylcysteine in the inhibition of proliferation and collagen synthesis of human pulmonary fibroblasts.].
Topics: Acetylcysteine; Cells, Cultured; Collagen Type I; Fibroblasts; Humans; Transforming Growth Factor beta | 2009 |
Scavenging of reactive oxygen species in mitochondria induces myofibroblast differentiation.
Topics: Acetylcysteine; Actins; Antioxidants; Cell Differentiation; Chromans; Fibroblasts; Fibronectins; Humans; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Mitochondria; Muscle, Smooth; Myofibroblasts; Phosphorylation; Plastoquinone; Reactive Oxygen Species; Signal Transduction; Transforming Growth Factor beta | 2010 |
Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells.
Topics: Acetylcysteine; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Carcinoma; Cell Line, Tumor; Female; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Oxides; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta; Ubiquitin-Activating Enzymes | 2010 |
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.
Topics: Acetylcysteine; Actins; Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Kidney Diseases; Leupeptins; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Ureteral Obstruction | 2011 |
Cross-talk between microRNAs, nuclear factor E2-related factor 2, and heme oxygenase-1 in ochratoxin A-induced toxic effects in renal proximal tubular epithelial cells.
Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Deferoxamine; Epithelial Cells; Erythropoietin; Gene Expression Regulation; Heme Oxygenase-1; Kidney Tubules, Proximal; MicroRNAs; NF-E2-Related Factor 2; Ochratoxins; Reactive Oxygen Species; Signal Transduction; Swine; Transforming Growth Factor beta | 2013 |
The protective effect of antioxidants on orbital fibroblasts from patients with Graves' ophthalmopathy in response to oxidative stress.
Topics: Acetylcysteine; Adult; Antioxidants; Ascorbic Acid; Cell Proliferation; Cell Survival; Female; Fibroblasts; Graves Ophthalmopathy; Humans; Hydrogen Peroxide; Interleukin-1beta; Intracellular Space; Male; Orbit; Oxidative Stress; Protective Agents; Transforming Growth Factor beta | 2013 |
Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.
Topics: Acetaldehyde; Acetylcysteine; Animals; Cell Nucleus; Collagen Type II; Cytosol; DNA-Binding Proteins; Down-Regulation; Fibronectins; Genes, Reporter; Hepatic Stellate Cells; Humans; Mice; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Repressor Proteins; Response Elements; RNA, Messenger; Smad Proteins; Smad3 Protein; Smad4 Protein; Smad7 Protein; Transcription, Genetic; Transforming Growth Factor beta; Up-Regulation | 2014 |
Inhibitory effect of N-acetyl cysteine and ascorbic acid on the development of myringosclerosis: an experimental study.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Female; Fibrin Foam; Fibroblasts; Free Radical Scavengers; Guinea Pigs; Hemostatics; Immunohistochemistry; Inflammation; Leukocytes; Microscopy; Mucous Membrane; Myringosclerosis; Nitric Oxide Synthase; Random Allocation; Transforming Growth Factor beta; Tympanic Membrane; Vascular Endothelial Growth Factor A | 2014 |
[Transforming growth factor-β1 induced cellular proliferation and collagen synthesis was mediated by reactive oxygen species in pulmonary fibroblasts].
Topics: Acetylcysteine; Cell Proliferation; Collagen; Collagen Type I; Fibroblasts; Hydrogen Peroxide; Lung; MAP Kinase Signaling System; Phosphorylation; Reactive Oxygen Species; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2015 |
Involvement of smad2 and Erk/Akt cascade in TGF-β1-induced apoptosis in human gingival epithelial cells.
Topics: Acetylcysteine; Apoptosis; Benzamides; Caspase 3; Caspase 7; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dioxoles; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Gingiva; Humans; Inflammation; MAP Kinase Signaling System; Periodontitis; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2015 |
Cytoplasmic translocation of HuR contributes to angiotensin II induced cardiac fibrosis.
Topics: Acetylcysteine; Angiotensin II; Animals; Collagen; Cytoplasm; Dose-Response Relationship, Drug; ELAV Proteins; Heart Diseases; Male; Mice; Mice, Inbred C57BL; Protein Transport; Reactive Oxygen Species; Transforming Growth Factor beta | 2015 |
Effects of hydrogen sulfide on acetaminophen-induced acute renal toxicity in rats.
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Acute-Phase Proteins; Analgesics, Non-Narcotic; Animals; Apoptosis; Cell Adhesion Molecules; Free Radical Scavengers; Hydrogen Sulfide; Kidney Tubules; Lipocalin-2; Lipocalins; Male; Oxidative Stress; Proto-Oncogene Proteins; Rats; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2019 |
Exposure to acrylamide and reduced heart rate variability: The mediating role of transforming growth factor-β.
Topics: Acetylcysteine; Acrylamide; Adult; Heart Rate; Humans; Transforming Growth Factor beta; Transforming Growth Factors | 2020 |
Old age-associated enrichment of peripheral T regulatory cells and altered redox status in pulmonary tuberculosis patients.
Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Aged; Cytokines; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Programmed Cell Death 1 Receptor; T-Lymphocytes, Regulatory; Th1 Cells; Transforming Growth Factor beta; Tuberculosis, Pulmonary; Young Adult | 2020 |
Administration of N-Acetylcysteine to Regress the Fibrogenic and Proinflammatory Effects of Oxidative Stress in Hypertrophic Ligamentum Flavum Cells.
Topics: Acetylcysteine; Collagen Type I; Humans; Hydrogen Peroxide; Hypertrophy; Ligamentum Flavum; Oxidative Stress; Transforming Growth Factor beta; Vimentin | 2022 |