acetylcysteine and tiopronin

acetylcysteine has been researched along with tiopronin in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199012 (32.43)18.7374
1990's9 (24.32)18.2507
2000's6 (16.22)29.6817
2010's9 (24.32)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Brimacombe, KR; Dulcey, AE; Goldsborough, AS; Gottesman, MM; Griffiths, G; Hall, MD; Handley, MD; Kannan, P; Pluchino, KM1
Cuesta-Bernal, J; El-Delik, J; Frank, D; Göttig, S; Klingler, FM; Koenigs, A; Müller, HF; Pogoryelov, D; Pos, KM; Proschak, E; Sjuts, H; Wichelhaus, TA2
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Pomarelli, P1
Rice-Evans, C; Udupi, V1
Goldschmidt, JE; Tallarida, RJ1
Davies, MJ; Newman, ES; Rice-Evans, CA; Turner, JJ1
Denneberg, T; Lindell, A; Mårtensson, J; Textorius, O1
Delecoeuillerie, G; Paul, JL; Raichvarg, D; Rommain, M1
Brien, G; de Temple, R; Hellmann, C; Otting, U; Schönberger, B; Schöpke, W1
Kachru, DN; Khandelwal, S; Tandon, SK1
Harman, AW; Self, G1
Becker, FF; Chan, JY; Stout, DL1
Fantini, L; Frova, C; Mondani, P; Scuri, R1
Anfossi, DG; Fusi, L; Orsi, R1
Massey, TE; McElligott, TF; Racz, WJ; Walker, RM1
Cavrini, V; Di Pietra, AM; Raggi, MA1
Lallier, R1
Davis, M; Smith, HM; Tredger, JM; Williams, R1
Beyersbergen van Henegouwen, GM; van den Broeke, LT1
Lopez Garcia, I; Martinez Gil, JA; Viñas, P1
Hoener, B; Shen, W1
Czyzyk-Krzeska, MF; Kroll, SL1
Aono, H; Horiuchi, M; Matsuoka, H; Mita, S; Nishimura, K; Takai, M; Tsuji, F1
Natarajan, V; Parinandi, NL; Scribner, WM; Shi, S; Vepa, S1
Atmaca, G1
Korge, P; Weiss, JN1
Brennan, JP; Davidson, SM; Duchen, MR; Medina, RA; Shattock, MJ; Southworth, R1
Dhalla, NS; Saini-Chohan, HK1
Sajewicz, W1
Abdallah, Y; Erdogan, A; Gündüz, D; Iraqi, W; Kasseckert, SA; Ladilov, Y; Neuhof, C; Piper, HM; Reusch, HP; Said, M; Schlüter, KD; Shahzad, T; Tillmanns, H1
Buck, LT; Dukoff, DJ; Hawrysh, PJ; Hogg, DW1
Barancik, M; Bartekova, M; Dhalla, NS; Ferenczyova, K1
Gottesman, MM; Hall, MD; Horibata, S; Huff, LM; Robey, RW1

Reviews

3 review(s) available for acetylcysteine and tiopronin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Antioxidant effects of sulfur-containing amino acids.
    Yonsei medical journal, 2004, Oct-31, Volume: 45, Issue:5

    Topics: Acetylcysteine; Amino Acids, Sulfur; Antioxidants; Cysteine; Glutathione; Methionine; Structure-Activity Relationship; Taurine; Thioctic Acid; Tiopronin

2004
Beneficial Effects of N-acetylcysteine and N-mercaptopropionylglycine on Ischemia Reperfusion Injury in the Heart.
    Current medicinal chemistry, 2018, Jan-30, Volume: 25, Issue:3

    Topics: Acetylcysteine; Animals; Antioxidants; Heart; Humans; Myocardial Reperfusion Injury; Oxidative Stress; Tiopronin

2018

Other Studies

34 other study(ies) available for acetylcysteine and tiopronin

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Collateral sensitivity of multidrug-resistant cells to the orphan drug tiopronin.
    Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Multidrug Resistance-Associated Proteins; Orphan Drug Production; Paclitaxel; RNA Stability; RNA, Messenger; Structure-Activity Relationship; Tiopronin

2011
Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.
    Journal of medicinal chemistry, 2015, Apr-23, Volume: 58, Issue:8

    Topics: Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Crystallography, X-Ray; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Humans; Imipenem; Klebsiella Infections; Klebsiella pneumoniae; Models, Molecular; Pseudomonas aeruginosa; Pseudomonas Infections; Sulfhydryl Compounds

2015
Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.
    Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15

    Topics:

2015
[Pharmacological study of an antibiotic-mucolytic combination].
    Il Farmaco; edizione pratica, 1978, Volume: 33, Issue:9

    Topics: Acetylcysteine; Amino Acids, Sulfur; Animals; Bacteria; Bronchi; Cats; Dogs; Drug Combinations; Erythromycin; Expectorants; Female; Fetus; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Mice; Rabbits; Rats; Respiration; Tiopronin

1978
Thiol compounds as protective agents in erythrocytes under oxidative stress.
    Free radical research communications, 1992, Volume: 16, Issue:5

    Topics: Acetylcysteine; Anemia, Sickle Cell; Antioxidants; Erythrocytes; Humans; Oxidation-Reduction; Thiomalates; Tiopronin

1992
Pharmacological evidence that captopril possesses an endothelium-mediated component of vasodilation: effect of sulfhydryl groups on endothelium-derived relaxing factor.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:3

    Topics: Acetylcholine; Acetylcysteine; Animals; Captopril; Cyclic GMP; Enalaprilat; Endothelium, Vascular; Glutathione; In Vitro Techniques; Nitric Oxide; Norepinephrine; Pyrogallol; Rabbits; Structure-Activity Relationship; Sulfhydryl Compounds; Superoxide Dismutase; Tiopronin; Vasodilation

1991
The formation of free radicals by cardiac myocytes under oxidative stress and the effects of electron-donating drugs.
    The Biochemical journal, 1991, Aug-01, Volume: 277 ( Pt 3)

    Topics: Acetylcysteine; Animals; Deferoxamine; Electron Spin Resonance Spectroscopy; Free Radicals; In Vitro Techniques; Lipid Peroxides; Metmyoglobin; Myocardium; Oxidation-Reduction; Peroxides; Rabbits; Reperfusion Injury; Tiopronin

1991
Sulfur amino acid metabolism in cystinuria: a biochemical and clinical study of patients.
    Kidney international, 1990, Volume: 37, Issue:1

    Topics: Acetylcysteine; Adult; Amino Acids, Sulfur; Cysteine; Cystinuria; Female; Homozygote; Humans; Male; Penicillamine; Tiopronin

1990
[Inhibitory action of tiopronin on free radicals].
    Revue du rhumatisme et des maladies osteo-articulaires, 1989, Apr-30, Volume: 56, Issue:5 Pt 2

    Topics: Acetylcysteine; Animals; Dose-Response Relationship, Drug; Female; Free Radicals; Luminescent Measurements; Macrophages; Male; Mice; Neutrophils; Oxygen; Rats; Rats, Inbred Strains; Tiopronin

1989
[Treatment and metaphylaxis of cystine urolithiasis in children].
    Kinderarztliche Praxis, 1989, Volume: 57, Issue:9

    Topics: Acetylcysteine; Administration, Oral; Adolescent; Cystinuria; Female; Humans; Kidney Calculi; Nephrostomy, Percutaneous; Recurrence; Therapeutic Irrigation; Tiopronin

1989
Chelation in metal intoxication. XXVIII: Effect of thiochelators on mercury (II) toxicity: pre- and post treatment.
    Biochemistry international, 1988, Volume: 16, Issue:5

    Topics: Acetylcysteine; Acrylates; Animals; Chelating Agents; Male; Mercury; Mercury Poisoning; Mercury Radioisotopes; Rats; Rats, Inbred Strains; Spironolactone; Tiopronin

1988
Comparison of the protective effects of N-acetylcysteine, 2-mercaptopropionylglycine and dithiothreitol against acetaminophen toxicity in mouse hepatocytes.
    Toxicology, 1986, Volume: 41, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Amino Acids, Sulfur; Animals; Cells, Cultured; Dithiothreitol; Glutathione; Liver; Male; Mice; Tiopronin

1986
Protective role of thiols in carcinogen-induced DNA damage in rat liver.
    Carcinogenesis, 1986, Volume: 7, Issue:10

    Topics: Acetylcysteine; Animals; Carcinogens; Diethylnitrosamine; DNA; DNA Damage; Female; Glutathione; Liver; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tiopronin

1986
Nesosteine: a new mucoregulatory agent.
    Drugs under experimental and clinical research, 1986, Volume: 12, Issue:8

    Topics: Acetylcysteine; Animals; Bronchi; Expectorants; Male; Mucus; Rabbits; Terpenes; Thiazoles; Tiopronin; Trachea; Viscosity

1986
[Histological evaluation in an experimental model (swine retina) of drugs solubilizing the vitreous body].
    Bollettino della Societa italiana di biologia sperimentale, 1985, Aug-30, Volume: 61, Issue:8

    Topics: Acetylcysteine; Amino Acids, Sulfur; Animals; Swine; Tiopronin; Vitreous Body

1985
Ultrastructural effects of acetaminophen in isolated mouse hepatocytes.
    Experimental and molecular pathology, 1983, Volume: 39, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Cell Survival; Cytoplasm; Liver; Male; Mice; Microscopy, Electron; Microvilli; Tiopronin

1983
Colorimetric determination of acetylcysteine, penicillamine, and mercaptopropionylglycine in pharmaceutical dosage forms.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:12

    Topics: Acetylcysteine; Amino Acids, Sulfur; Capsules; Colorimetry; Penicillamine; Solutions; Spectrophotometry; Tablets; Tiopronin

1982
Biological properties of cis- and trans- dichlorodiammineplatinum.
    Cell biology international reports, 1980, Volume: 4, Issue:7

    Topics: Acetylcysteine; Animals; Blastocyst; Cisplatin; Female; Gastrula; Glutathione; Sea Urchins; Stereoisomerism; Tiopronin; Zygote

1980
Effects of sulphur-containing compounds on paracetamol activation and covalent binding in a mouse hepatic microsomal system.
    Toxicology letters, 1980, Volume: 5, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteamine; In Vitro Techniques; Male; Methionine; Mice; Microsomes, Liver; Mixed Function Oxygenases; Sulfur; Tiopronin

1980
UV-radiation protecting efficacy of thiols, studied with UVA-induced binding of 8-MOP and CPZ to rat epidermal biomacromolecules in vivo.
    International journal of radiation biology, 1993, Volume: 63, Issue:4

    Topics: Acetylcysteine; Animals; Captopril; Chlorpromazine; Cysteamine; Epidermis; Ergothioneine; Female; Mesna; Methoxsalen; Penicillamine; Radiation-Protective Agents; Rats; Rats, Wistar; Sulfhydryl Compounds; Tiopronin; Ultraviolet Rays

1993
Determination of thiol-containing drugs by chemiluminescence-flow injection analysis.
    Journal of pharmaceutical and biomedical analysis, 1993, Volume: 11, Issue:1

    Topics: Acetylcysteine; Catalysis; Copper; Cysteine; Flow Injection Analysis; Hydrogen Peroxide; Hydrogen-Ion Concentration; Luminescent Measurements; Luminol; Penicillamine; Sulfhydryl Compounds; Tiopronin

1993
Mitigation of nitrofurantoin-induced toxicity in the perfused rat liver.
    Human & experimental toxicology, 1996, Volume: 15, Issue:5

    Topics: Acetylcysteine; Adenosine Monophosphate; Animals; Anti-Infective Agents, Urinary; Antidotes; Cell Death; Chelating Agents; Dithiothreitol; Egtazic Acid; Free Radical Scavengers; Free Radicals; Glutathione; L-Lactate Dehydrogenase; Liver; Male; Nitrofurantoin; Oxidation-Reduction; Oxidative Stress; Penicillamine; Perfusion; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Sulfobromophthalein; Tiopronin

1996
Role of H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Acetylcysteine; Actins; Amitrole; Animals; Antioxidants; Biosensing Techniques; Catalase; Cell Hypoxia; Deferoxamine; Gene Expression Regulation, Enzymologic; Heme; Hydrogen Peroxide; Kinetics; Oxygen; PC12 Cells; Rats; RNA, Messenger; Tiopronin; Transcription, Genetic; Tyrosine 3-Monooxygenase

1998
Effects of sulfhydryl compounds on interleukin-1-induced vascular endothelial growth factor production in human synovial stromal cells.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:5

    Topics: Acetylcysteine; Cells, Cultured; Cysteine; Endothelial Growth Factors; Humans; Interleukin-1; Lymphokines; Penicillamine; Stromal Cells; Sulfhydryl Compounds; Synovial Membrane; Tiopronin; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Phospholipase D activation in endothelial cells is redox sensitive.
    Antioxidants & redox signaling, 1999,Summer, Volume: 1, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Cattle; Cell Line; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Intracellular Fluid; Oxidation-Reduction; Phospholipase D; Phosphorylation; Phosphotyrosine; Pulmonary Artery; Reactive Oxygen Species; Sulfhydryl Compounds; Sulfhydryl Reagents; Thiourea; Tiopronin

1999
Redox regulation of endogenous substrate oxidation by cardiac mitochondria.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:3

    Topics: 3-Mercaptopropionic Acid; Acetylcysteine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Catalase; Cell Respiration; Electron Transport; Enzyme Inhibitors; Fatty Acids; Hydrogen Peroxide; Mitochondria, Heart; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen Consumption; Phosphorylation; Rabbits; Reactive Oxygen Species; Tiopronin

2006
Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.
    Cardiovascular research, 2006, Nov-01, Volume: 72, Issue:2

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Decanoic Acids; Dose-Response Relationship, Drug; Free Radical Scavengers; Glyburide; Hydroxy Acids; Ischemic Preconditioning, Myocardial; Magnetic Resonance Spectroscopy; Male; Microscopy, Fluorescence; Mitochondria, Heart; Myocardial Ischemia; Perfusion; Potassium Channels; Rats; Rats, Wistar; Reactive Oxygen Species; Tiopronin; Uncoupling Agents

2006
Attenuation of ischemia-reperfusion-induced alterations in intracellular Ca2+ in cardiomyocytes from hearts treated with N-acetylcysteine and N-mercaptopropionylglycine.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:12

    Topics: Acetylcysteine; Animals; Caffeine; Calcium; Cardiotonic Agents; Cell Survival; Dose-Response Relationship, Drug; Free Radical Scavengers; Heart; Male; Myocytes, Cardiac; Ouabain; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Tiopronin

2009
Effect of thiol drugs on tert-butyl hydroperoxide induced luminol chemiluminescence in human erythrocytes, erythrocyte lysate, and erythrocyte membranes.
    Chemico-biological interactions, 2010, Jul-30, Volume: 186, Issue:2

    Topics: Acetylcysteine; Erythrocyte Membrane; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Luminescence; Luminol; Mesna; Models, Biological; Oxidative Stress; Penicillamine; Sulfhydryl Compounds; tert-Butylhydroperoxide; Tiopronin

2010
Interplay between Ca2+ cycling and mitochondrial permeability transition pores promotes reperfusion-induced injury of cardiac myocytes.
    Journal of cellular and molecular medicine, 2011, Volume: 15, Issue:11

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Cyclosporine; Fluoresceins; Male; Membrane Potential, Mitochondrial; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Reperfusion Injury; Myocytes, Cardiac; Necrosis; Rats; Rats, Wistar; Reactive Oxygen Species; Ruthenium Compounds; Ryanodine; Thapsigargin; Tiopronin

2011
Scavenging ROS dramatically increase NMDA receptor whole-cell currents in painted turtle cortical neurons.
    The Journal of experimental biology, 2014, Sep-15, Volume: 217, Issue:Pt 18

    Topics: Acetylcysteine; Animals; Calcium; Cerebral Cortex; Female; Free Radical Scavengers; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Neurons; Oxygen; Patch-Clamp Techniques; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Rotenone; Tiopronin; Turtles

2014
Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale.
    Journal of medicinal chemistry, 2020, 02-13, Volume: 63, Issue:3

    Topics: Acetylcysteine; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mycoplasma fermentans; Mycoplasma Infections; Tiopronin

2020