Compounds > acetylcysteine

acetylcysteine and thiophenes

acetylcysteine has been researched along with thiophenes in 35 studies

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.57)18.7374
1990's6 (17.14)18.2507
2000's14 (40.00)29.6817
2010's11 (31.43)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Christie, BJ; Guy, RW; Hickman, RJ; White, TJ1
Dansette, PM; el Amri, H; Mansuy, D; Thang, DC1
Barrett-Bee, K; Cox, A; Davis, SS; Marriott, C; Readman, AS1
Edwards, K; Jones, AR1
Bray, HG; Carpanini, FM; Waters, BD1
Fisher, PL; Fliesler, SJ; Keller, PK; Pittler, SJ; Rapp, LM1
Bagnasco, M; Bennicelli, C; Camoirano, A; De Flora, S; Kensler, TW; Qian, GS; van Zandwijk, N; Wigbout, G; Zhu, YR1
Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ1
Egner, PA; Groopman, JD; He, X; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Muñoz, A; Qian, GS; Shen, X; Wang, JB; Wang, JS; Zarba, A; Zhang, BC; Zhu, YR1
Balansky, RM; Bennicelli, C; Dagostini, F; De Flora, S; Grubbs, CJ; Izzotti, A; Kelloff, GJ; Lubet, RA; Myers, SR1
Bolanowska-Higdon, W; Creaven, PJ; Hitt, S; Lawrence, D; Murphy, M; Pendyala, L; Schwartz, G; Zdanowicz, J1
Briehl, MM; Dorr, RT; Dvorakova, K; Payne, CM; Tome, ME; Waltmire, CN1
Camoirano, A; Cartiglia, C; De Flora, S; Izzotti, A; Tampa, E1
Hosoe, H; Kaise, T; Ohmori, K1
Armutcu, F; Iraz, M; Kotuk, M; Kuku, I; Ozen, S; Ulu, R; Yildirim, Z1
Demiralay, R; Erdem, H; Gürsan, N3
Erdogan, H; Fadillioglu, E; Irmak, MK; Uçar, M; Yagmurca, M1
Bhat, GJ; Niture, SK; Smith, QR; Srivenugopal, KS; Velu, CS1
Alkan, A; Alsancak, G; Cerçi, C; Ergin, C; Eroğlu, E; Eroğlu, F1
Ding, J; Feng, JM; Miao, ZH; Zhang, XW; Zhu, H1
Güven, A; Korkmaz, A; Kul, M; Ongürü, O; Oter, S; Sarici, U; Topal, T; Tunc, T1
Calin, GA; Cartiglia, C; Croce, CM; De Flora, S; Izzotti, A; Longobardi, M; Steele, VE1
Erbaş, M; Erkan, ME; Gezer, S; Güneş, H; Kandiş, H; Kara, IH; Yildirim, HA; Yildirim, U1
Islam, KN; Koch, WJ1
Baltaci, D; Colakoglu, S; Kandis, H; Kara, IH; Karakus, A; Kaya, H; Memisogullari, R; Saritas, A; Yildirim, U1
Ireland, DJ; Keelan, JA; Kemp, MW; Newnham, JP; Payne, MS; Stinson, LF; Stock, SJ1
Bonewald, L; Brotto, M; Igwe, O; Mo, C; Vallejo, J; Wetmore, L; Zhao, R1
Feng, Y; Jin, W; Li, H; Pan, H; Zhao, T; Zhao, Y1
Choi, JH; Jang, DS; Kim, NJ; Lee, JY; Lee, KT; Preya, UH1
Calzetta, L; Cazzola, M; Hanania, NA; Matera, MG; Rogliani, P1
Avdonin, PP; Avdonin, PV; Goncharov, NV; Mironova, GY; Nadeev, AD; Zharkikh, IL1
Calzetta, L; Cazzola, M; Matera, MG; Page, C; Puxeddu, E; Rogliani, P1
Adir, Y; Avdeev, S; Calverley, PMA; Cordeiro, CR; Jesenak, M; Koblížek, V; Papi, A; Petkova, D; Rogliani, P; Tarraf, H; Tzanakis, N; Ulmeanu, R; Uzaslan, E1

Reviews

2 review(s) available for acetylcysteine and thiophenes

ArticleYear
Impact of Mucolytic Agents on COPD Exacerbations: A Pair-wise and Network Meta-analysis.
    COPD, 2017, Volume: 14, Issue:5

    Topics: Acetylcysteine; Ambroxol; Carbocysteine; Disease Progression; Expectorants; Humans; Network Meta-Analysis; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Thioglycolates; Thiophenes

2017
Efficacy and safety profile of mucolytic/antioxidant agents in chronic obstructive pulmonary disease: a comparative analysis across erdosteine, carbocysteine, and N-acetylcysteine.
    Respiratory research, 2019, May-27, Volume: 20, Issue:1

    Topics: Acetylcysteine; Antioxidants; Carbocysteine; Expectorants; Humans; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Thioglycolates; Thiophenes; Treatment Outcome

2019

Trials

2 trial(s) available for acetylcysteine and thiophenes

ArticleYear
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
    Journal of the National Cancer Institute, 1999, Feb-17, Volume: 91, Issue:4

    Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome

1999
Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:3

    Topics: Acetylcysteine; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Pyrazines; Reference Values; Risk Assessment; Smoking; Thiones; Thiophenes

2001

Other Studies

31 other study(ies) available for acetylcysteine and thiophenes

ArticleYear
Thioethers as urinary metabolites of thiophene and monobromothiophenes.
    Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:8

    Topics: Acetylcysteine; Animals; Bromine; Glutathione; Male; Rats; Rats, Wistar; Sulfides; Thiophenes

1992
Evidence for thiophene-S-oxide as a primary reactive metabolite of thiophene in vivo: formation of a dihydrothiophene sulfoxide mercapturic acid.
    Biochemical and biophysical research communications, 1992, Aug-14, Volume: 186, Issue:3

    Topics: Acetylcysteine; Animals; Biotransformation; Carbon Isotopes; Hydrogen; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains; Thiophenes; Tritium

1992
A new mucotropic agent--in vitro and in vivo evaluation of 2-alpha-thenoylthiopropionylglycine (bronchoplus).
    European journal of respiratory diseases, 1985, Volume: 67, Issue:2

    Topics: Acetylcysteine; Animals; Dithiothreitol; Expectorants; Glycine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Models, Biological; Mucus; Rheology; Sulfides; Swine; Swine, Miniature; Thiophenes; Time Factors; Viscosity

1985
Studies with alkylating esters. IV. The metabolism of propane-1,3-dimethanesulphonate and its relevance to the mode of action of Myleran.
    Biochemical pharmacology, 1971, Volume: 20, Issue:8

    Topics: 1-Propanol; Acetylcysteine; Animals; Biotransformation; Busulfan; Carbon Isotopes; Chemosterilants; Chromatography, Paper; Esters; In Vitro Techniques; Male; Methane; Mice; Propylene Glycols; Rabbits; Rats; Spermatozoa; Sulfonic Acids; Sulfur; Sulfur Isotopes; Thiophenes

1971
The metabolism of thiophen in the rabbit and the rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1971, Volume: 1, Issue:2

    Topics: Acetylcysteine; Animals; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Cysteine; Feces; Female; Mass Spectrometry; Rabbits; Rats; Spectrophotometry, Infrared; Sulfates; Sulfur Radioisotopes; Thiophenes

1971
In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.
    The Journal of cell biology, 1995, Volume: 130, Issue:2

    Topics: Acetates; Acetylcysteine; Animals; Benzylamines; Cell Nucleus; Cholesterol; Female; Lipids; Lovastatin; Photoreceptor Cells; Protein Prenylation; Rats; Retina; Squalene; Sterols; Thiophenes

1995
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials.
    Journal of cellular biochemistry. Supplement, 1996, Volume: 25

    Topics: Acetylcysteine; Adult; Anticarcinogenic Agents; Biomarkers, Tumor; Chemoprevention; China; Clinical Trials, Phase II as Topic; Cohort Studies; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenicity Tests; Mutagens; Netherlands; Pyrazines; Research Design; Smoking; Thiones; Thiophenes

1996
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 40, Issue:1

    Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays

1997
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
    Cancer research, 2001, Mar-15, Volume: 61, Issue:6

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Biomarkers; DNA Adducts; DNA Damage; Eating; Hemoglobins; Inhalation Exposure; Lung; Male; Micronuclei, Chromosome-Defective; Nicotiana; Oxidation-Reduction; Plants, Toxic; Pyrazines; Rats; Rats, Sprague-Dawley; Smoke; Smoking; Thiones; Thiophenes; Tobacco Smoke Pollution; Weight Gain

2001
Induction of mitochondrial changes in myeloma cells by imexon.
    Blood, 2001, Jun-01, Volume: 97, Issue:11

    Topics: Acetone; Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Cytochrome c Group; DNA Damage; DNA, Mitochondrial; Electron Transport Complex II; Flow Cytometry; Hexanones; Humans; Leukemia, Promyelocytic, Acute; Lymphocytes; Membrane Potentials; Microscopy, Electron; Mitochondria; Multienzyme Complexes; Multiple Myeloma; Oxidative Stress; Oxidoreductases; Polymerase Chain Reaction; Reactive Oxygen Species; Succinate Dehydrogenase; Thiophenes; Tumor Cells, Cultured

2001
Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.
    Mutation research, 2001, Jul-25, Volume: 494, Issue:1-2

    Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Chemoprevention; DNA Adducts; Eating; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Smoking; Thiones; Thiophenes; Weight Gain

2001
Effects on the reactive oxygen species of erdosteine and its metabolite in vitro.
    Arzneimittel-Forschung, 2002, Volume: 52, Issue:6

    Topics: Acetylcysteine; Antioxidants; Glutathione; Hydrogen Peroxide; Hypochlorous Acid; Kinetics; Reactive Oxygen Species; Superoxides; Thioglycolates; Thiophenes

2002
Attenuation of bleomycin-induced lung fibrosis by oral sulfhydryl containing antioxidants in rats: erdosteine and N-acetylcysteine.
    Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Bleomycin; Disease Models, Animal; Drug Interactions; Male; Pulmonary Fibrosis; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Thioglycolates; Thiophenes

2005
The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of pulmonary cells.
    Toxicology, 2006, Feb-15, Volume: 219, Issue:1-3

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Bronchoalveolar Lavage Fluid; Epithelial Cells; Expectorants; Lung; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peroxidase; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Tumor Necrosis Factor-alpha; Vitamin E

2006
Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: protective effects of erdosteine and N-acetylcysteine.
    Urological research, 2006, Volume: 34, Issue:1

    Topics: Acetylcysteine; Animals; Free Radical Scavengers; Kidney Diseases; Kidney Tubules; Lipid Peroxidation; Male; Oxidation-Reduction; Oxidative Stress; Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioglycolates; Thiophenes

2006
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
    Carcinogenesis, 2007, Volume: 28, Issue:2

    Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Base Sequence; Biological Products; Blotting, Western; Cell Line, Tumor; Curcumin; Cysteine; DNA Modification Methylases; DNA Primers; DNA Repair Enzymes; Dose-Response Relationship, Drug; Fenretinide; Glutathione; Glutathione S-Transferase pi; Humans; Lymphocytes; Prodrugs; Pyrazines; RNA, Messenger; Silymarin; Thiones; Thiophenes; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins

2007
Protective effects of N-acetylcysteine and erdosteine on hemorrhagic shock-induced acute lung injury.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2006, Volume: 13, Issue:5

    Topics: Acetylcysteine; Animals; Blood Pressure; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Free Radical Scavengers; Glutathione; Lung; Macrophages, Alveolar; Male; Malondialdehyde; Neutrophils; Premedication; Random Allocation; Rats; Rats, Wistar; Respiratory Distress Syndrome; Shock, Hemorrhagic; Thioglycolates; Thiophenes

2006
Regulation of sepsis-induced apoptosis of pulmonary cells by posttreatment of erdosteine and N-aceylcysteine.
    Toxicology, 2006, Dec-07, Volume: 228, Issue:2-3

    Topics: Acetylcysteine; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Epithelial Cells; Free Radical Scavengers; Immunohistochemistry; In Situ Nick-End Labeling; Lipopolysaccharides; Lung; Peroxidase; Pneumonia; Rats; Rats, Wistar; Sepsis; Thioglycolates; Thiophenes; Tissue Embedding; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A

2006
The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells.
    Journal of cellular biochemistry, 2008, Aug-01, Volume: 104, Issue:5

    Topics: Acetylcysteine; Animals; Apoptosis; Hippocampus; Neurons; Nicotine; Peroxidase; Rats; Rats, Wistar; Thioglycolates; Thiophenes; Tocopherols; Tumor Necrosis Factor-alpha

2008
Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.
    Cancer biology & therapy, 2008, Volume: 7, Issue:11

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Inhibitors; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Naphthalimides; Proteasome Endopeptidase Complex; Protein Kinases; Thiophenes; Time Factors; Topoisomerase II Inhibitors; Ubiquitin

2008
Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.
    Journal of gastroenterology and hepatology, 2009, Volume: 24, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Constriction; Disease Models, Animal; Glutathione Peroxidase; Ileum; Lipid Peroxidation; Male; Malondialdehyde; Mesenteric Artery, Superior; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sexual Development; Sulfhydryl Compounds; Superoxide Dismutase; Thioctic Acid; Thioglycolates; Thiophenes

2009
Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.
    Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:1

    Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; beta-Naphthoflavone; Chemoprevention; Cluster Analysis; Enzyme Inhibitors; Gene Expression; Indoles; Isothiocyanates; Lung; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes; Tobacco Smoke Pollution

2010
Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication.
    Human & experimental toxicology, 2011, Volume: 30, Issue:9

    Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Data Interpretation, Statistical; Female; Kidney; Kidney Function Tests; Radionuclide Imaging; Rats; Rats, Wistar; Thioglycolates; Thiophenes

2011
Involvement of nuclear factor κB (NF-κB) signaling pathway in regulation of cardiac G protein-coupled receptor kinase 5 (GRK5) expression.
    The Journal of biological chemistry, 2012, Apr-13, Volume: 287, Issue:16

    Topics: Acetylcysteine; Animals; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation, Enzymologic; Heart Diseases; Myocytes, Cardiac; NF-kappa B p50 Subunit; Primary Cell Culture; Promoter Regions, Genetic; Rats; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor RelA

2012
N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage.
    Toxicology and industrial health, 2014, Volume: 30, Issue:7

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Antidotes; Antipyretics; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; International Normalized Ratio; Oxidants; Prothrombin Time; Rats; Rats, Wistar; Thioglycolates; Thiophenes

2014
Effects of cytokine-suppressive anti-inflammatory drugs on inflammatory activation in ex vivo human and ovine fetal membranes.
    Reproduction (Cambridge, England), 2014, Volume: 147, Issue:3

    Topics: Acetylcysteine; Amides; Animals; Anti-Inflammatory Agents; Cell-Penetrating Peptides; Cells, Cultured; Cytokines; Dinoprostone; Extraembryonic Membranes; Female; Humans; Imidazoles; Inflammation; Pregnancy; Pyrimidines; Sheep; Thiophenes

2014
Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation.
    Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:10

    Topics: Acetylcysteine; Alprostadil; Animals; Cell Proliferation; Cells, Cultured; Dinoprostone; G1 Phase Cell Cycle Checkpoints; Immunohistochemistry; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts; Reactive Oxygen Species; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Thiophenes; Triazoles

2015
Rosbin, a synthetic small molecule, induces A549 cells apoptosis through a ROS-mediated pathway.
    Cell biology international, 2017, Volume: 41, Issue:2

    Topics: A549 Cells; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Caspase 9; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Mitochondria; Piperidines; Reactive Oxygen Species; Thiophenes

2017
The natural terthiophene α-terthienylmethanol induces S phase cell cycle arrest of human ovarian cancer cells via the generation of ROS stress.
    Chemico-biological interactions, 2017, Jun-25, Volume: 272

    Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cyclin A; Cyclin-Dependent Kinase 2; DNA Damage; Eclipta; Female; Histones; Humans; Ovarian Neoplasms; Phosphorylation; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Thiophenes

2017
Enhancement by Hydrogen Peroxide of Calcium Signals in Endothelial Cells Induced by 5-HT1B and 5-HT2B Receptor Agonists.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Acetylcysteine; Benzoxazoles; Calcium; Calcium Signaling; Fluorescence; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Indoles; Quinoxalines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2B; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Thiophenes; Triazoles; Vanadates

2019
Use of mucolytics in COPD: A Delphi consensus study.
    Respiratory medicine, 2020, Volume: 175

    Topics: Acetylcysteine; Carbocysteine; Consensus; Drug Therapy, Combination; Expectorants; Female; Health Status; Humans; Internationality; Male; Practice Guidelines as Topic; Pulmonary Disease, Chronic Obstructive; Surveys and Questionnaires; Symptom Flare Up; Thioglycolates; Thiophenes; Treatment Outcome

2020