acetylcysteine has been researched along with thiazoles in 99 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (11.11) | 18.7374 |
| 1990's | 22 (22.22) | 18.2507 |
| 2000's | 46 (46.46) | 29.6817 |
| 2010's | 17 (17.17) | 24.3611 |
| 2020's | 3 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Ledl, F | 1 |
| Khoury, MD; Pereira, MA | 1 |
| Brodeur, J; Goyal, R; Tardif, R | 1 |
| Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Robert, A | 1 |
| Abney, NL; Maatta, EA; Perchellet, EM; Perchellet, JP | 1 |
| Davis, BB; Rice, JR; Spry, LA; Zenser, TV | 1 |
| Hayes, MA; Kim, HL; Merrill, JC; Murray, CA; Safe, S | 1 |
| Brodeur, J; Goyal, R | 1 |
| Fantini, L; Frova, C; Mondani, P; Scuri, R | 1 |
| Hazelton, GA; Hjelle, JJ; Klaassen, CD | 1 |
| Bakke, JE; Gustafsson, BE; Gustafsson, JA; Rafter, JJ | 1 |
| Brunet, C; Cazin, JC; Cazin, M; Dine, T; Gressier, B; Lebegue, N; Luyckx, M | 1 |
| Herzenberg, LA; Raju, PA; Roederer, M | 1 |
| Banks, MF; Stipanuk, MH | 1 |
| Moog, C; Obert, G; Simon, G | 1 |
| Aldershvile, J; Anderson, ME; Boesgaard, S; Loft, S; Meister, A; Poulsen, HE | 1 |
| Breborowicz, A; Martis, L; Oreopoulos, DG; Patrikarea, A | 1 |
| Ida, N; Maeda, K; Miyazaki, T; Murata, Y; Nagaya, T; Sato, M; Seo, H | 1 |
| Baba, M; Kira, T; Matsuyama, M; Merin, JP; Okamoto, T | 1 |
| Bauer, G; Chen, P; Factor, R; Markham, R; Mitchell, J; Schwartz, DH | 1 |
| Greene, JJ; Hutter, DE; Till, BG | 1 |
| Arons, MM; Bernard, GR; Morris, PE; Paz, HL; Russell, JA; Wheeler, AP; Wright, PE | 1 |
| Arstrand, K; Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Beani, JC; Emonet, N; Favier, A; Leccia, MT; Richard, MJ | 1 |
| Brash, DE; Chu, E; Ju, J; Liu, M; Pelling, JC | 1 |
| Funato, H; Kohsaka, S; Mochizuki, H; Shimojo, M; Takasugi, K; Yamamoto, I | 1 |
| Dringen, R; Hamprecht, B | 1 |
| Averill, DA; Lord-Fontaine, S | 1 |
| Correa, R; De la Fuente, M; Del Rio, M; Ferrández, MD | 1 |
| Grzybowski, AE | 1 |
| Blanco, B; Correa, R; De la Fuente, M; Del Rio, M; Ferrández, MD; Guaza, C; Hernanz, A | 1 |
| Dizdar, N; Kågedal, B; Kullman, A | 1 |
| Hammarqvist, F; Wernerman, J | 1 |
| Abas, L; Bogoyevitch, MA; Court, NW; Dhillon, A; Draper, KA; Ng, DC | 1 |
| Birnboim, HC; Privora, H | 1 |
| Herman, TS; Martinez, BR; Meltz, ML; Mohan, S; Natarajan, M | 1 |
| Baysang, G; Brack, C; Brockhaus, M; Meier, F; Müller-Spahn, F; Olivieri, G; Stähelin, HB | 1 |
| Brown, MK; Fraley, TS; Kaetzel, RS; Reed, DJ; Will, Y | 1 |
| Catalán, MP; De La Fuente, M; Guayerbas, N; Miquel, J; Víctor, VM | 1 |
| Bruggisser, R; Jundt, G; Schaffner, W; Tullberg-Reinert, H; von Daeniken, K | 1 |
| De La Fuente, M; Ferrández, MD; Guayerbas, N; Puerto, M | 1 |
| Simkeviciene, V; Straukas, J; Uleckiene, S | 1 |
| de Groene, EM; Fink-Gremmels, J; Maas, RF; Schaaf, GJ | 1 |
| Hanada, S; Harada, M; Koga, H; Kumashiro, R; Kumemura, H; Namba, M; Ohira, H; Sata, M; Sato, Y; Shishido, S; Taniguchi, E; Ueno, T | 1 |
| Aksenov, ND; Efremova, TN; Gamaleĭ, IA; Kirpichnikova, KM | 1 |
| Bryła, J; Drozak, J; Jagielski, AK; Wegrzynowicz, M; Winiarska, K | 1 |
| Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E | 1 |
| Bodo, CC; Cabilla, JP; Duvilanski, BH; Poliandri, AH; Velardez, MO | 1 |
| Beretta, S; Carrì, MT; Casciati, A; Ceresa, C; Ferrarese, C; Ferri, A; Mattavelli, L; Sala, G | 1 |
| Broaddus, WC; Dent, P; Fisher, PB; Gopalkrishnan, RV; Grant, S; Lebedeva, IV; Lister, A; McKinstry, R; Mitchell, C; Qiao, L; Ramakrishnan, V; Sarkar, D; Sigmon, C; Su, ZZ; Yacoub, A | 1 |
| BUYSKE, DA; COLUCCI, DF | 1 |
| Santangelo, F | 1 |
| Baek, SY; Chung, BS; Kang, CD; Kim, JY; Kim, SD; Kim, SH; Park, KH; Park, SW | 1 |
| Arriaza, E; Cara, C; Di Paola, M; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Lorusso, M; Menor, C; Olleros, T; Román, ID | 1 |
| Chung, HY; Je, JH; Jung, KJ; Lee, JY; Yu, BP | 1 |
| Andreoni, S; Appollonio, I; Begni, B; Beretta, S; Brighina, L; Ferrarese, C; Fumagalli, L; Isella, V; Malaplate-Armand, C; Oster, T; Sirtori, E | 1 |
| Dauer, WT; Dietrich, P; Rideout, HJ; Stefanis, L; Wang, Q | 1 |
| Efremova, TN; Gamaleĭ, IA; Khaĭtlina, SIu; Kirpichnikova, KM | 1 |
| De Martino, L; Florio, S; Gabellini, C; Giordano, A; Iovane, G; Marsili, S; Montagnaro, S; Pacelli, F; Pacilio, M; Pagnini, U; Rocco, D | 1 |
| Alvarez, P; de la Fuente, M; Guayerbas, N; Puerto, M | 1 |
| Gabryel, B; Małecki, A; Toborek, T | 1 |
| Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N | 1 |
| Deutsch, M; Herman, S; Zurgil, N | 1 |
| Atlas, D; Bartov, O; Butterfield, DA; Sultana, R | 1 |
| Lee, YC; Park, SJ | 1 |
| Aschner, M; Kaur, P; Syversen, T | 1 |
| Di Monte, DA; Johnston, LC; Langston, WJ; Reaney, SH | 1 |
| Hong, H; Ji, ZN; Liu, GQ; Lu, Y | 1 |
| Gean, PW; Huang, LJ; Kuo, SC; Lin, CH | 1 |
| Liu, M; Luo, T; McNeill, JH; Ouyang, J; Sharma, V; Wu, Y; Xia, Z | 1 |
| Cai, T; Chen, J; Chen, Y; Du, K; Li, Y; Luo, W; Yao, T | 1 |
| Cheng, X; Li, D; Meng, Q; Shen, C | 1 |
| Cabilla, JP; Duvilanski, BH; Machiavelli, LI; Miler, EA; Quinteros, FA | 1 |
| Aschner, M; Au, C; Batoréu, MC; Marreilha dos Santos, AP; Milatovic, D; Santos, D | 1 |
| Du, Y; Fan, X; Le, W; Li, X; Luo, G; Yang, D | 1 |
| Ahmed, K; Kondo, T; Matsuya, Y; Nemoto, H; Shimizu, T; Sugiyama, T; Yoshihisa, Y; Zaidi, SF | 1 |
| Kerk, SY; Lim, TM; Xiong, GG; Zhou, ZD | 1 |
| Anantharam, V; Bravosanpedro, JM; Fuentes, JM; González-Polo, RA; Kanthasamy, AG; Morán, JM; Niso-Santano, M; Ortiz-Ortiz, MA; Soler, G | 1 |
| Chan, WH; Choi, MM; Li, HW; Xiao, L; Zhao, D | 1 |
| Galindo, MF; Jordán, J; Manzanares, J; Perez-Alvarez, S; Solesio, ME | 1 |
| Biswas, S; Dutta, AK; Le, W; Li, C; Li, X | 1 |
| Ambrosio, L; D'Antò, V; Martina, R; Rengo, S; Schweikl, H; Spagnuolo, G; Valletta, R | 1 |
| Dubé, A; Harrisson, JF; Saint-Gelais, G; Séguin, C | 1 |
| Abdul-Razzak, KK; Aldaher, AN; Alkofahi, AS; Alsarhan, AM; Mhaidat, NM; Thorne, RF | 1 |
| Arai, M; Hikita, E; Hirano, T; Onda, K; Tanaka, S; Toyoda, H; Utsumi, H; Yuan, B | 1 |
| Gai, R; He, Q; Luo, P; Wu, H; Wu, Y; Xue, T; Yang, B; Yang, X; Zhao, Y; Zhu, H | 1 |
| Suo, YR; Zhang, C; Zhao, YF | 1 |
| Hadano, S; Hirayama, N; Ikeda, JE; Kanno, T; Tanaka, K; Yanagisawa, Y; Yasutake, K; Yoshii, F | 1 |
| Amato, M; D'Antò, V; Desiderio, C; Lupi, A; Nocca, G; Rengo, S; Rivieccio, V; Rossetti, DV; Schweikl, H; Spagnuolo, G | 1 |
| Hiraishi, N; Kasugai, S; Nassar, M; Ohya, K; Otsuki, M; Shimokawa, H; Tagami, J; Tamura, Y | 1 |
| Avalos, A; Haza, AI; Mateo, D; Morales, P | 2 |
| Cheng, B; Li, J; Liu, D; Pan, H; Wu, Q | 1 |
| Cheng, B; Li, J; Liu, D; Pan, W; Tan, G | 1 |
| Beane, WS; Tseng, AS; Van Huizen, AV | 1 |
| Choi, SE; Koh, HC; Park, YS | 1 |
| Chen, L; Chen, X; Cheng, H; Dai, X; Gao, T; Huang, X; Li, H; Lin, M; Shao, B; Shen, C; Wang, Y; Yang, S; Yu, J; Zhao, D; Zheng, B; Zhong, X; Zhou, Q | 1 |
| Bae, ON; Choi, S; Kim, D; Kim, EH; Lim, KM; Majid, A; Tie, L | 1 |
| Bertram, J; Kraus, T; Schettgen, T | 1 |
3 review(s) available for acetylcysteine and thiazoles
| Article | Year |
|---|---|
Modulation of endogenous glutathione availability.
Topics: Acetylcysteine; Animals; Cysteine; Glutamine; Glutathione; Humans; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
Intracellular thiol concentration modulating inflammatory response: influence on the regulation of cell functions through cysteine prodrug approach.
Topics: Acetylcysteine; Acute-Phase Proteins; Animals; Cell Cycle; Cysteine; Cytokines; Glutathione; Humans; Inflammation; Prodrugs; Sulfhydryl Compounds; Thiazoles | 2003 |
Antioxidants as novel agents for asthma.
Topics: Acetylcysteine; Anti-Asthmatic Agents; Antioxidants; Asthma; Cysteine; Glutathione; Humans; Oxidative Stress; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2006 |
1 trial(s) available for acetylcysteine and thiazoles
| Article | Year |
|---|---|
A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group.
Topics: Acetylcysteine; Adult; Antioxidants; Bilirubin; Bronchoalveolar Lavage Fluid; Cardiac Output; Cysteine; Double-Blind Method; Free Radical Scavengers; Glutathione; Humans; Middle Aged; Prospective Studies; Pyrrolidonecarboxylic Acid; Respiration, Artificial; Respiratory Distress Syndrome; Thiazoles; Thiazolidines; Time Factors | 1997 |
95 other study(ies) available for acetylcysteine and thiazoles
| Article | Year |
|---|---|
[Thermal decomposition of cysteine, cystine, N-acetylcysteine, 4-thiazolidinecarboxylic acid and cysteine methyl ester in soy bean oil (authors transl)].
Topics: Acetylcysteine; Antioxidants; Carboxylic Acids; Cysteine; Cystine; Drug Stability; Esters; Glycine max; Hot Temperature; Oils; Thiazoles | 1976 |
Prevention by chemopreventive agents of azoxymethane-induced foci of aberrant crypts in rat colon.
Topics: Acetylcysteine; Allyl Compounds; Animals; Anticarcinogenic Agents; Azoxymethane; Colon; Colonic Neoplasms; Dehydroepiandrosterone; Eflornithine; Ellagic Acid; Isothiocyanates; Male; Precancerous Conditions; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Sulfides; Thiazoles; Thiazolidines; Thiocyanates | 1991 |
Influence of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid, on the urinary elimination of mercapturic acids of ethylene oxide, dibromoethane, and acrylonitrile: a dose-effect study.
Topics: Acetylcysteine; Acrylonitrile; Animals; Ethylene Dibromide; Ethylene Oxide; Glutathione; Hydrocarbons, Brominated; Kidney; Liver; Male; Nitriles; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Time Factors | 1989 |
Role of glutathione status in protection against ethanol-induced gastric lesions.
Topics: Acetylcysteine; Animals; Cysteamine; Ethanol; Gastric Mucosa; Glutathione; Male; Maleates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Stomach Ulcer; Thiazoles; Thiazolidines | 1989 |
Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate
Topics: Acetylcysteine; Animals; Cells, Cultured; Ditiocarb; Epidermis; Female; Glutathione; Glutathione Peroxidase; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 1987 |
Effect of peroxidase inhibitors on an in vivo metabolite of the urinary bladder carcinogen N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats.
Topics: Acetylcysteine; Animals; Carcinogens; FANFT; Glutathione; Male; Methimazole; Peroxidases; Propylthiouracil; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Thiazoles; Urinary Bladder Neoplasms | 1988 |
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.
Topics: Acetylcysteine; Animals; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1988 |
Effect of a cysteine prodrug (L-2-oxothiazolidine-4-carboxylic acid) on the metabolism and toxicity of bromobenzene: a repeated exposure study.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromobenzenes; Glutathione; Inactivation, Metabolic; Male; Metabolic Clearance Rate; Mice; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1987 |
Nesosteine: a new mucoregulatory agent.
Topics: Acetylcysteine; Animals; Bronchi; Expectorants; Male; Mucus; Rabbits; Terpenes; Thiazoles; Tiopronin; Trachea; Viscosity | 1986 |
Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Biotransformation; Cysteine; Glucuronates; Glucuronic Acid; Glutathione; Kinetics; Liver; Liver Glycogen; Male; Mice; Phosphoadenosine Phosphosulfate; Protein Binding; Pyrrolidonecarboxylic Acid; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1986 |
The effect of intestinal microflora on the enterohepatic circulation of mercapturic acid pathway metabolites.
Topics: Acetanilides; Acetylcysteine; Animals; Anti-Inflammatory Agents; Chlorobenzenes; Enterohepatic Circulation; Germ-Free Life; Inactivation, Metabolic; Intestines; Male; Models, Biological; Polychlorinated Biphenyls; Rats; Rats, Inbred Strains; Thiazoles | 1981 |
Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs.
Topics: Acetylcysteine; Antioxidants; Dose-Response Relationship, Drug; Drug Interactions; Expectorants; Free Radical Scavengers; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxyl Radical; Hypochlorous Acid; Mesna; Reactive Oxygen Species; Respiratory Burst; Superoxides; Thiazoles; Thiazolidines | 1995 |
Glutathione precursor and antioxidant activities of N-acetylcysteine and oxothiazolidine carboxylate compared in in vitro studies of HIV replication.
Topics: Acetylcysteine; Antimetabolites; Antioxidants; Antiviral Agents; Buthionine Sulfoximine; Cells, Cultured; Free Radical Scavengers; Gene Expression Regulation, Viral; Genes, Reporter; Glutathione; HIV Long Terminal Repeat; HIV-1; Humans; Leukocytes, Mononuclear; Methionine Sulfoximine; Monocytes; Prodrugs; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha; Virus Replication | 1994 |
The utilization of N-acetylcysteine and 2-oxothiazolidine-4-carboxylate by rat hepatocytes is limited by their rate of uptake and conversion to cysteine.
Topics: Acetylcysteine; Animals; Cells, Cultured; Culture Media; Cysteine; Glutathione; Liver; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Selenium Radioisotopes; Thiazoles; Thiazolidines | 1994 |
Effects of glutathione precursors on human immunodeficiency virus replication.
Topics: Acetylcysteine; beta-Galactosidase; Cell Line; Colorimetry; Gene Expression Regulation, Viral; Glutathione; Granulocyte-Macrophage Colony-Stimulating Factor; HIV; HIV Long Terminal Repeat; Homocysteine; Humans; Interleukin-6; Prodrugs; Pyrrolidonecarboxylic Acid; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Virus Replication | 1994 |
Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.
Topics: Acetylcysteine; Animals; Arteries; Drug Tolerance; Female; Nitrates; Nitroglycerin; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Veins | 1994 |
L-2-Oxothiazolidine-4-carboxylate and N-acetylcysteine as precursors of intracellular glutathione in human peritoneal mesothelial cells.
Topics: Acetylcysteine; Cells, Cultured; Epithelial Cells; Epithelium; Free Radical Scavengers; Free Radicals; Glutathione; Humans; Peritoneum; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1996 |
Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8, monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells.
Topics: Acetylcysteine; Antioxidants; Arthritis, Rheumatoid; Cells, Cultured; Chemokine CCL2; Collagenases; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Interleukin-8; NF-kappa B; Pyrrolidonecarboxylic Acid; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidines; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1996 |
Alpha-lipoic acid blocks HIV-1 LTR-dependent expression of hygromycin resistance in THP-1 stable transformants.
Topics: Acetylcysteine; Antioxidants; Cell Line; Drug Resistance; Gene Expression Regulation, Viral; HIV Core Protein p24; HIV Long Terminal Repeat; HIV-1; Humans; Hygromycin B; Macrophages; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Plasmids; Promoter Regions, Genetic; Tetrazolium Salts; Thiazoles; Thioctic Acid; Transfection; Tumor Necrosis Factor-alpha | 1996 |
N-acetyl-cysteine and L-2-oxothiazolidine-4-carboxylic acid enhance contact-dependent growth of HIV in resting peripheral blood mononuclear cells (PBMC) in vitro and increase recovery of HIV from human-PBMC SCID mice.
Topics: Acetylcysteine; Animals; Anti-HIV Agents; CD2 Antigens; Cell Division; Cells, Cultured; Coculture Techniques; Down-Regulation; Female; HIV-1; Humans; Intercellular Adhesion Molecule-1; Leukocytes, Mononuclear; Male; Mice; Mice, SCID; Monocytes; Peritoneal Cavity; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Virus Replication; Zidovudine | 1997 |
Redox state changes in density-dependent regulation of proliferation.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cell Division; Cell Line; Contact Inhibition; Fibroblasts; Fibrosarcoma; Glutathione; Humans; Male; Neoplasm Proteins; Oxidation-Reduction; Protein Binding; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transcription Factors; Tumor Cells, Cultured | 1997 |
Effects on interstitial glutathione, cysteine and 5-S-cysteinyldopa of buthionine sulphoximine in human melanoma transplants.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Drug Interactions; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microdialysis; Neoplasm Transplantation; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1997 |
Thiols and selenium: protective effect on human skin fibroblasts exposed to UVA radiation.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Cysteine; Dose-Response Relationship, Radiation; Female; Fibroblasts; Glutathione; Humans; Pyrrolidonecarboxylic Acid; Radiation-Protective Agents; Skin; Sodium Selenite; Surgery, Plastic; Thiazoles; Thiazolidines; Thiophenes; Ultraviolet Rays | 1997 |
Antioxidant action via p53-mediated apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Buthionine Sulfoximine; Cells, Cultured; Dimercaprol; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Glutathione; Mice; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Vitamin E | 1998 |
Neuroprotective action of a novel compound--M50463--in primary cultured neurons.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Batrachotoxins; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Neurons; Neuroprotective Agents; Neurotoxins; Nicardipine; Nitroprusside; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Thiazoles; Veratrine; Vitamin E | 1999 |
N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain.
Topics: Acetylcysteine; Animals; Brain; Cells, Cultured; Cysteine; Female; Glutathione; Methionine; Neurons; Pregnancy; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Thiazoles; Thiazolidines | 1999 |
Enhancement of cytotoxicity of hydrogen peroxide by hyperthermia in chinese hamster ovary cells: role of antioxidant defenses.
Topics: Acetylcysteine; Amitrole; Animals; Antioxidants; Buthionine Sulfoximine; Catalase; Cell Survival; CHO Cells; Cricetinae; Enzyme Inhibitors; Glutathione; Hot Temperature; Hydrogen Peroxide; Intracellular Fluid; Mesna; Oxidation-Reduction; Protective Agents; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines | 1999 |
Effects in vitro of several antioxidants on the natural killer function of aging mice.
Topics: Acetylcysteine; Aging; Animals; Antioxidants; Ascorbic Acid; Killer Cells, Natural; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Peritoneum; Spleen; Thiazoles; Thiazolidines; Thymus Gland; Vitamin E | 1999 |
In vitro effect of glutathione precursors on cytotoxicity of amino acids to human mesothelial cells.
Topics: Acetylcysteine; Amino Acids; Biological Transport; Cell Membrane; Cells, Cultured; Epithelial Cells; Glutathione; Growth Inhibitors; Humans; Intracellular Fluid; Peritoneum; Potassium; Protein Precursors; Pyrrolidonecarboxylic Acid; Rubidium Radioisotopes; Thiazoles; Thiazolidines | 1999 |
Changes in several functions of murine peritoneal macrophages by N-acetylcysteine and thioproline ingestion. Comparative effect between two strains of mice.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Adhesion; Chemotaxis; Dietary Supplements; Female; In Vitro Techniques; Interleukin-1; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Phagocytosis; Species Specificity; Superoxides; Thiazoles; Thiazolidines | 1999 |
Comparison of N-acetylcysteine and l-2-oxothiazolidine-4-carboxylate as cysteine deliverers and glutathione precursors in human malignant melanoma transplants in mice.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cysteine; Cysteinyldopa; Enzyme Inhibitors; Glutathione; Humans; Melanoma; Melanoma, Experimental; Mice; Mice, Nude; Microdialysis; Neoplasm Transplantation; Protein Precursors; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Intact mitochondrial electron transport function is essential for signalling by hydrogen peroxide in cardiac myocytes.
Topics: Acetylcysteine; Animals; Animals, Newborn; Antifungal Agents; Cells, Cultured; Dose-Response Relationship, Drug; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Free Radicals; Glutathione Transferase; Heart Ventricles; Hydrogen Peroxide; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Methacrylates; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardium; Osmotic Pressure; Oxidative Stress; Phenylephrine; Phosphorylation; Protein Kinases; Rats; Signal Transduction; Thiazoles; Time Factors; Tyrosine; Uncoupling Agents | 2000 |
Depletion of intracellular glutathione reduces mutations by nitric oxide-donating drugs.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Gamma Rays; Glutathione; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenesis; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 2000 |
Antioxidant compounds interfere with the 3.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Colorimetry; Coloring Agents; Culture Media; Dithiothreitol; Kinetics; Melatonin; Mercaptoethanol; Oxidation-Reduction; Pyrrolidines; Pyrrolidonecarboxylic Acid; Reagent Kits, Diagnostic; Sulfhydryl Compounds; Tetrazolium Salts; Thiazoles; Thiazolidines; Thiocarbamates; Vitamin E | 2000 |
N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation.
Topics: Acetylcysteine; Amyloid beta-Peptides; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutathione; Glutathione Reductase; Humans; Hydrogen Peroxide; Neuroblastoma; Oxidative Stress; Peptide Fragments; Phosphorylation; tau Proteins; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Ultraviolet Rays | 2001 |
In vivo reversal of glutathione deficiency and susceptibility to in vivo dexamethasone-induced apoptosis by N-acetylcysteine and L-2-oxothiazolidine-4-carboxylic acid, but not ascorbic acid, in thymocytes from gamma-glutamyltranspeptidase-deficient knocko
Topics: Acetylcysteine; Animals; Apoptosis; Ascorbic Acid; Dexamethasone; gamma-Glutamyltransferase; Glutathione; Mice; Mice, Knockout; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Thymus Gland | 2002 |
The amount of thiolic antioxidant ingestion needed to improve several immune functions is higher in aged than in adult mice.
Topics: Acetylcysteine; Aging; Animals; Antioxidants; Cell Adhesion; Chemotaxis, Leukocyte; Diet; Dose-Response Relationship, Drug; Female; Leukocytes; Lymphocytes; Mice; Phagocytosis; Sulfhydryl Compounds; Superoxides; Thiazoles; Thiazolidines | 2002 |
Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Breast Neoplasms; Cell Division; Cell Survival; Drug Interactions; Estrogens, Non-Steroidal; Flavonoids; Humans; Isoflavones; Kaempferols; Phytoestrogens; Plant Extracts; Plant Preparations; Plants; Quercetin; Resveratrol; Stilbenes; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vitamin E | 2002 |
A diet supplemented with thiolic anti-oxidants improves leucocyte function in two strains of prematurely ageing mice.
Topics: Acetylcysteine; Aging, Premature; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Female; Leukocytes; Mice; Mice, Inbred BALB C; Species Specificity; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 2002 |
N-acetil-l-cysteine and 2-amino-2-thiiazoline N-acetyl-l-cysteinate as a possible cancer chemopreventive agents in murine models.
Topics: Acetylcysteine; Adenoma; Animals; Anticarcinogenic Agents; Dose-Response Relationship, Drug; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Models, Animal; Thiazoles | 2002 |
Management of oxidative stress by heme oxygenase-1 in cisplatin-induced toxicity in renal tubular cells.
Topics: Acetylcysteine; alpha-Tocopherol; Animals; Antioxidants; Blotting, Western; Cell Line; Cell Survival; Cisplatin; Coloring Agents; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Kidney Tubules; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Oxygen Species; Swine; Tetrazolium Salts; Thiazoles; Time Factors | 2002 |
Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes.
Topics: Acetylcysteine; Albumins; Antioxidants; Cell Line, Transformed; Cell Polarity; Chromans; Cytochrome c Group; Free Radical Scavengers; Hepatocytes; Humans; Hydrogen Peroxide; Ligands; Microscopy, Electron; Mitochondria; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
[Effect of agents changing the intracellular level of reactive oxygen species on the cell cycle phase distribution in 3T3 and 3T3SV40 cell lines].
Topics: 3T3 Cells; Acetylcysteine; Animals; Antioxidants; Apoptosis; Buthionine Sulfoximine; Cell Cycle; Cell Line, Transformed; Dose-Response Relationship, Drug; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2003 |
Relationship between gluconeogenesis and glutathione redox state in rabbit kidney-cortex tubules.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Enzyme Inhibitors; Gluconeogenesis; Glutathione; Intracellular Membranes; Kidney Cortex; Kidney Tubules; Male; Oxidation-Reduction; Pyrrolidonecarboxylic Acid; Rabbits; Thiazoles; Thiazolidines | 2003 |
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.
Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Cadmium; Caspases; Cell Survival; Chromans; DNA Fragmentation; Free Radical Scavengers; Hormones; Immunohistochemistry; Male; Oxidative Stress; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles; Vitamin E | 2003 |
Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine.
Topics: Acetylcysteine; Adenosine Triphosphate; Amyotrophic Lateral Sclerosis; Blotting, Western; Caspase 3; Caspases; Cell Death; DNA Fragmentation; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; L-Lactate Dehydrogenase; Mitochondria; Mutation; Neuroblastoma; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2003 |
Melanoma differentiation-associated 7 (interleukin 24) inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo.
Topics: Acetylcysteine; Adenoviridae; Animals; Astrocytes; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Brain Neoplasms; Cell Division; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Down-Regulation; Gene Transfer Techniques; Genes, Tumor Suppressor; Glioblastoma; Glioma; Glutathione Transferase; Humans; Interleukins; Necrosis; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
THE BIOTRANSFORMATION OF A SULFONAMIDE TO A MERCAPTAN AND TO MERCAPTURIC ACID AND GLUCURONIDE CONJUGATES.
Topics: Acetylcysteine; Animals; Biotransformation; Chromatography; Dogs; Glucuronates; Glucuronides; Liver; Metabolism; Rabbits; Rats; Research; Spectrophotometry; Sulfhydryl Compounds; Sulfonamides; Thiazoles; Ultraviolet Rays | 1965 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; MPTP Poisoning; PC12 Cells; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Apoptosis; Azathioprine; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA; DNA Fragmentation; Glutathione; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mitochondria, Liver; Mitogen-Activated Protein Kinase 3; Necrosis; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Stress, Physiological; Superoxides; Tetrazolium Salts; Thiazoles; Thymidine; Tritium | 2004 |
Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation.
Topics: Acetylcysteine; Aging; Aldehydes; Animals; Apoptosis; Blotting, Western; Cell Nucleus; Cell Survival; Coloring Agents; Culture Media, Serum-Free; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Free Radicals; Gene Expression Regulation; Lipid Peroxidation; Luciferases; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitriles; Oxidation-Reduction; Oxidative Stress; Prostate; Rats; Sulfones; Tetrazolium Salts; Thiazoles; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2004 |
Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease.
Topics: Acetylcysteine; Adenosine Triphosphate; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Glutamic Acid; Glutathione; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Cytoplasm; Genotype; Lewy Bodies; Mice; Mice, Knockout; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Protease Inhibitors; Proteasome Inhibitors; Rats; Synucleins; Thiazoles; Time Factors; Ubiquitin | 2004 |
[Antioxidants-induced rearrangements of actin cytoskeleton in 3T3 and 3T3-SV40 fibroblasts].
Topics: 3T3 Cells; Acetylcysteine; Actin Cytoskeleton; Actins; Animals; Antioxidants; Cell Line, Transformed; Glutathione; Mice; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Simian virus 40; Stress Fibers; Thiazoles; Thiazolidines; Time Factors | 2004 |
The involvement of oxidative stress in bovine herpesvirus type 4-mediated apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Azoles; Butylated Hydroxyanisole; Cattle; Cell Line; Cell Proliferation; Coloring Agents; DNA Fragmentation; Herpesvirus 4, Bovine; Isoindoles; Kidney; Models, Statistical; Organoselenium Compounds; Oxidation-Reduction; Oxidative Stress; Oxygen; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2004 |
Improvement of the macrophage functions in prematurely ageing mice by a diet supplemented with thiolic antioxidants.
Topics: Acetylcysteine; Aging, Premature; Animals; Antioxidants; Chemotaxis; Diet; Female; Macrophages, Peritoneal; Maze Learning; Mice; Mice, Inbred ICR; Phagocytosis; Sulfhydryl Compounds; Superoxides; Thiazoles; Thiazolidines; Tumor Necrosis Factor-alpha | 2004 |
Immunosuppressive immunophilin ligands attenuate damage in cultured rat astrocytes depleted of glutathione and exposed to simulated ischemia in vitro. Comparison with N-acetylcysteine.
Topics: Acetylcysteine; Animals; Apoptosis; Astrocytes; Benzimidazoles; Brain Ischemia; Cell Separation; Cells, Cultured; Cyclosporine; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Immunophilins; Immunosuppressive Agents; Ligands; Mitochondria; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Tacrolimus; Tetrazolium Salts; Thiazoles | 2005 |
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells.
Topics: Acetylcysteine; Analysis of Variance; Area Under Curve; Buthionine Sulfoximine; Catalase; Cell Death; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cystine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Indolequinones; Iron; Melanins; Models, Biological; Neuroblastoma; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines.
Topics: Acetylcysteine; Annexin A5; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Arthritis, Rheumatoid; Biological Assay; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Immunosuppressive Agents; Jurkat Cells; Leukocytes; Methotrexate; Monocytes; Oxidative Stress; Propidium; Reactive Oxygen Species; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Time Factors; U937 Cells | 2005 |
Low molecular weight thiol amides attenuate MAPK activity and protect primary neurons from Abeta(1-42) toxicity.
Topics: Acetylcysteine; Amides; Amyloid beta-Peptides; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Cerebral Cortex; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Free Radical Scavengers; Glutathione; Lipid Peroxidation; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Weight; Neurons; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Tyrosine | 2006 |
Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes.
Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Cell Count; Cells, Cultured; Cerebellum; Drug Interactions; Enzyme Inhibitors; Ethylmaleimide; Glutathione; Mercury Poisoning, Nervous System; Methylmercury Compounds; Mice; Mitochondria; Neurons; Oxidoreductases; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2006 |
Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures.
Topics: Acetylcysteine; Analysis of Variance; Animals; Cell Count; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Immunohistochemistry; Mesencephalon; Neurons; Neurotoxins; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Tritium | 2006 |
Up-regulation of P-glycoprotein expression by glutathione depletion-induced oxidative stress in rat brain microvessel endothelial cells.
Topics: Acetylcysteine; Animals; Animals, Newborn; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brain; Buthionine Sulfoximine; Cell Death; Dose-Response Relationship, Drug; Drug Interactions; Endothelial Cells; Enzyme Inhibitors; Free Radical Scavengers; Glutathione; L-Lactate Dehydrogenase; Oxidative Stress; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2006 |
Neuroprotective effect of N-acetylcysteine on neuronal apoptosis induced by a synthetic gingerdione compound: involvement of ERK and p38 phosphorylation.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cell Count; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Guaiacol; In Situ Nick-End Labeling; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles | 2006 |
N-acetylcysteine attenuates TNF-alpha-induced human vascular endothelial cell apoptosis and restores eNOS expression.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Flow Cytometry; Glutathione; Glutathione Peroxidase; Humans; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2006 |
Proteasome inhibition is associated with manganese-induced oxidative injury in PC12 cells.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Apoptosis; Cell Count; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; In Situ Nick-End Labeling; Manganese Compounds; Oxidative Stress; PC12 Cells; Proteasome Endopeptidase Complex; Protein Carbonylation; Rats; Tetrazolium Salts; Thiazoles; Trace Elements | 2007 |
Investigation of rifampicin-induced hepatotoxicity in rat hepatocytes maintained in gel entrapment culture.
Topics: Acetylcysteine; Albumins; Animals; Antitubercular Agents; Cell Culture Techniques; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Drug Antagonism; Enzyme Inhibitors; Glutathione; Glycyrrhizic Acid; Hepatocytes; Lipid Metabolism; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rifampin; Tetrazolium Salts; Thiazoles | 2009 |
Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspases; Catalase; Cells, Cultured; Chromium; DNA Primers; Male; Oxidative Stress; Pituitary Gland, Anterior; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2008 |
Antioxidants prevent the cytotoxicity of manganese in RBE4 cells.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Cell Line, Transformed; Cell Survival; Chlorides; Chromans; Dose-Response Relationship, Drug; Endothelial Cells; Glutathione; L-Lactate Dehydrogenase; Manganese Compounds; Rats; Sulfates; Tetrazolium Salts; Thiazoles | 2008 |
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Cytochromes c; Dopamine; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; Tetrazolium Salts; Thiazoles | 2008 |
Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain.
Topics: Acetylcysteine; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Calcium; Caspase 3; Caspase 8; Cell Division; Cytochromes c; Heterocyclic Compounds; Humans; MAP Kinase Kinase 4; Protein Kinase Inhibitors; Reactive Oxygen Species; Thiazoles; U937 Cells | 2009 |
Dopamine auto-oxidation aggravates non-apoptotic cell death induced by over-expression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Benzimidazoles; Cell Death; Chromatography, High Pressure Liquid; Cysteine; Dopamine; Enzyme Inhibitors; Flow Cytometry; Fluorescent Dyes; Free Radical Scavengers; Glutathione; Humans; Monophenol Monooxygenase; Mutation; Nerve Growth Factor; Oxidation-Reduction; PC12 Cells; Rats; Tetrazolium Salts; Thiazoles; Transfection | 2009 |
Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Cell Line, Transformed; Curcumin; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Gene Expression Regulation; Herbicides; Hydrogen Peroxide; Mesencephalon; Neurons; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Paraquat; Rats; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Tyrosine; Vitamin E | 2009 |
Inhibition of beta 1-40 amyloid fibrillation with N-acetyl-L-cysteine capped quantum dots.
Topics: Acetylcysteine; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Peptide Fragments; Quantum Dots; Thiazoles | 2010 |
Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria, Liver; Neuroblastoma; Reactive Oxygen Species; Recombinant Fusion Proteins; Tetrazolium Salts; Thiazoles | 2009 |
Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin.
Topics: Acetylcysteine; Animals; Benzothiazoles; Biphenyl Compounds; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cysteine Proteinase Inhibitors; Dopamine Agonists; Dopamine Antagonists; Enzyme-Linked Immunosorbent Assay; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Indans; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neostriatum; Neuroprotective Agents; Parkinson Disease, Secondary; Piperazines; Postural Balance; Proteasome Endopeptidase Complex; Receptors, Dopamine D3; Thiazoles | 2010 |
Effect of N-acetyl cysteine on orthodontic primers cytotoxicity.
Topics: Acetylcysteine; Antioxidants; Cell Death; Cell Survival; Cells, Cultured; Coloring Agents; Dentin-Bonding Agents; Dose-Response Relationship, Drug; Ethanol; Fibroblasts; Flow Cytometry; Fluoresceins; Fluorescent Dyes; Gingiva; Humans; Hydrophobic and Hydrophilic Interactions; Methacrylates; Propidium; Reactive Oxygen Species; Resin Cements; Tetrazolium Salts; Thiazoles | 2011 |
Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1).
Topics: Acetylcysteine; Animals; Blotting, Northern; Cell Hypoxia; Chlorides; Chromosome Mapping; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Genes, Reporter; HEK293 Cells; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Luciferases; Metallothionein; Methacrylates; Mice; Mutagenesis, Site-Directed; NIH 3T3 Cells; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Stability; Rotenone; Signal Transduction; Thiazoles; Transcription Factor MTF-1; Transcription Factors; Transcriptional Activation; Transfection; Zinc Compounds | 2011 |
Altholactone induces apoptotic cell death in human colorectal cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase Inhibitors; Caspases, Initiator; Cell Death; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Enzyme Activation; Fibroblasts; Furans; Goniothalamus; HCT116 Cells; HT29 Cells; Humans; Oxidative Stress; Propidium; Pyrones; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2012 |
Effects of inorganic and organic arsenic compounds on growth and apoptosis of human T-lymphoblastoid leukemia cells.
Topics: Acetylcysteine; Apoptosis; Arsenic; Ascorbic Acid; Benzimidazoles; Buthionine Sulfoximine; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Female; Humans; Inhibitory Concentration 50; Leukemia, T-Cell; Leukocytes, Mononuclear; Models, Chemical; Organic Chemicals; T-Lymphocytes; Tetrazolium Salts; Thiazoles | 2011 |
Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Antioxidants; Apoptosis; Blotting, Western; Cell Separation; Dasatinib; DNA; Electrophoresis, Gel, Pulsed-Field; Fluorescent Dyes; Hepatocytes; In Situ Nick-End Labeling; Indoles; L-Lactate Dehydrogenase; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiazoles | 2012 |
MMPT as a reactive oxygen species generator induces apoptosis via the depletion of intracellular GSH contents in A549 cells.
Topics: Acetylcysteine; Aniline Compounds; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Cell Survival; G2 Phase Cell Cycle Checkpoints; Glutathione; Humans; Intracellular Space; M Phase Cell Cycle Checkpoints; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Thiazoles | 2012 |
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
Topics: Acetamides; Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidant Response Elements; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Female; Free Radical Scavengers; Gene Expression Regulation; Glutamate-Cysteine Ligase; HeLa Cells; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipid Peroxidation; Male; Metabolic Detoxication, Phase II; Mice; Mice, Transgenic; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Thiazoles | 2012 |
In vitro cellular detoxification of triethylene glycol dimethacrylate by adduct formation with N-acetylcysteine.
Topics: Acetylcysteine; Animals; Cell Culture Techniques; Cell Survival; Chromatography, High Pressure Liquid; Coloring Agents; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Capillary; Extracellular Space; Fibroblasts; Methacrylates; Mice; Polyethylene Glycols; Polymethacrylic Acids; Protective Agents; Swiss 3T3 Cells; Tandem Mass Spectrometry; Tetrazolium Salts; Thiazoles; Time Factors; Ultraviolet Rays | 2013 |
The inhibition effect of non-protein thiols on dentinal matrix metalloproteinase activity and HEMA cytotoxicity.
Topics: Acetylcysteine; Animals; Anti-Infective Agents, Local; Cell Line; Cell Survival; Chlorhexidine; Coloring Agents; Dental Materials; Dental Pulp; Dentin; Glutathione; Humans; Materials Testing; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Methacrylates; Phosphoric Acids; Rats; Tetrazolium Salts; Thiazoles | 2014 |
Interactions of manufactured silver nanoparticles of different sizes with normal human dermal fibroblasts.
Topics: Acetylcysteine; Antioxidants; Cell Survival; Cells, Cultured; Coloring Agents; Fibroblasts; Glutathione; Humans; L-Lactate Dehydrogenase; Metal Nanoparticles; Oxidative Stress; Particle Size; Reactive Oxygen Species; Silver Compounds; Skin; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2016 |
Effects of silver and gold nanoparticles of different sizes in human pulmonary fibroblasts.
Topics: Acetylcysteine; Antioxidants; Cardiotonic Agents; Cells, Cultured; Fibroblasts; Gold; Humans; Lung; Metal Nanoparticles; Oxidative Stress; Particle Size; Reactive Oxygen Species; Silver; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2015 |
Ex Vivo and in Vivo Evaluation of the Effect of Coating a Coumarin-6-Labeled Nanostructured Lipid Carrier with Chitosan-N-acetylcysteine on Rabbit Ocular Distribution.
Topics: Acetylcysteine; Animals; Chitosan; Cornea; Coumarins; Drug Carriers; Eye; Lipids; Nanoparticles; Nanostructures; Rabbits; Thiazoles | 2017 |
Transport mechanism of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin-6 loaded nanostructured lipid carriers across the rabbit ocular.
Topics: Acetylcysteine; Administration, Ophthalmic; Animals; Chitosan; Cornea; Coumarins; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Drug Liberation; Excipients; Lipids; Male; Nanostructures; Oligosaccharides; Ophthalmic Solutions; Particle Size; Permeability; Rabbits; Thiazoles | 2017 |
Methylisothiazolinone toxicity and inhibition of wound healing and regeneration in planaria.
Topics: Acetylcysteine; Animals; Antioxidants; Glutathione; Head; Planarians; Regeneration; Tail; Thiazoles; Water Pollutants, Chemical; Wound Healing | 2017 |
NF-κB/p53-activated inflammatory response involves in diquat-induced mitochondrial dysfunction and apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Caspase 3; Cyclooxygenase 2 Inhibitors; Diquat; Herbicides; Inflammation; Meloxicam; Mitochondria; NF-kappa B; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Signal Transduction; Thiazines; Thiazoles; Tumor Suppressor Protein p53 | 2018 |
BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p19; Heterocyclic Compounds, 2-Ring; Homeostasis; Leydig Cells; Male; Mice; Models, Biological; Oxidation-Reduction; Oxidative Stress; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Reactive Oxygen Species; Signal Transduction; Steroids; Testis; Testosterone; Thiazoles | 2020 |
A Commonly Used Biocide 2-N-octyl-4-isothiazolin-3-oneInduces Blood-Brain Barrier Dysfunction via Cellular Thiol Modification and Mitochondrial Damage.
Topics: Acetylcysteine; Animals; Antioxidants; Blood-Brain Barrier; Brain; Cell Death; Cell Line; Disinfectants; Endothelial Cells; Energy Metabolism; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Proteolysis; Reactive Oxygen Species; Sulfhydryl Compounds; Thiazoles; Tight Junction Proteins | 2021 |
New data on the metabolism of chloromethylisothiazolinone and methylisothiazolinone in human volunteers after oral dosage: excretion kinetics of a urinary mercapturic acid metabolite ("M-12").
Topics: Acetylcysteine; Administration, Oral; Adult; Disinfectants; Female; Half-Life; Humans; Male; Thiazoles; Young Adult | 2021 |