acetylcysteine and sirolimus

acetylcysteine has been researched along with sirolimus in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (33.33)29.6817
2010's21 (58.33)24.3611
2020's3 (8.33)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Egawa, K; Haruta, T; Kawahara, J; Kobayashi, M; Olefsky, JM; Sharma, PM; Takano, A; Uno, T1
Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Takano, A; Uno, T; Usui, I1
Martín, ME; O'Loghlen, A; Pérez-Morgado, MI; Salinas, M1
Nukiwa, T1
Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W1
Carrero, JC; Montfort, I; Nequiz, M; Olivos-García, A; Pérez-Tamayo, R; Ramos, E; Tello, E1
De Felici, M; Farini, D; Klinger, FG; Lobascio, AM; Scaldaferri, ML1
Borkin, MS; Boyd, SL; Koepke, JI; Terlecky, LJ; Terlecky, SR; Young, CN1
Jankovic, J; Kondo, S; Le, W; Pan, T; Xie, W; Zhu, W1
Bieri, M; Farkas, A; Koestner, SC; Ligeti, N; Meier, B; Mohacsi, PJ; Oroszlán, M1
Carreira, RS; Glembotski, CC; Gottlieb, RA; Huang, C; Iwai-Kanai, E; Perry, CN; Yuan, H1
Du, Y; Fan, X; Le, W; Li, L; Li, T; Luo, G; Wang, Q; Wang, Y; Yang, D; Zhang, X1
Chung, TY; Hyon, JY; Koh, JW; Shin, YJ; Wee, WR; Yi, K1
Arsikin, K; Bumbasirevic, V; Harhaji-Trajkovic, L; Jovanovic, M; Kravic-Stevovic, T; Ristic, B; Tovilovic, G; Trajkovic, V; Zogovic, N1
Chen, X; Ding, G; Ma, T; Singhal, PC; Zha, D; Zhu, J1
Benetti, F; de Carvalho Myskiw, J; Furini, CR; Izquierdo, I1
Chen, J; Hill, K; Lemasters, J; Sha, SH; Wang, X; Yang, SM; Yuan, H1
Beaupere, C; Capeau, J; Fève, B; Garcia, M; Lagathu, C; Larghero, J1
Aleksiejuk, P; Banki, K; Bonilla, E; Francis, L; Landas, SK; Liu, Y; Marchena-Mendez, I; Oaks, Z; Patel, J; Perl, A; Yu, J1
Ding, WX; Dobrowsky, RT; Ferguson-Smith, AC; Guo, F; Haug, JS; He, XC; Kono, T; Li, H; Li, L; Li, Z; Parmely, T; Paulson, A; Perry, JM; Qian, P; Tao, F; Venkatraman, A; Zhao, M; Zhi, L1
Bu, L; Mao, C; Mou, X; Wang, S; Wang, X; Wu, F; Xiao, Y; Xu, C; Yuan, G; Zheng, T; Zhou, Y1
Banki, K; Huang, N; Oaks, Z; Perl, A; Winans, T1
Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS1
Bai, Y; Jiang, L; Liu, N; Liu, X; Sun, X; Wang, S; Wu, X; Yang, G; Yao, X; Zhai, X1
Koleti, M; Tu, C; Xu, R; Zoldan, J1
Chai, R; Ding, X; Fang, Q; Gao, X; Guo, L; He, Z; Kong, W; Li, H; Liu, D; Liu, Y; Lu, L; Sha, S; Shu, Y; Tang, M; Zhang, X; Zhou, H1
Blokland, KEC; Burgess, JK; Grainge, C; Hogaboam, CM; Jaffar, J; Khalil, N; Knight, DA; Mutsaers, SE; Pechkovsky, DV; Prêle, CM; Read, J; Reid, AT; Schuliga, M; Waters, DW; Westall, G1
Chen, FP; Feng, G; Fu, YF; Liu, X; Mu, GF; Wang, X; Xiong, D1
Ma, J; Ran, Z; Wen, X; Zhang, Y1
Koh, HC; Park, A1
Alizadeh, S; Meshkani, R; Sadeghi, A; Shabani, M1
Haapasalo, A; Hiltunen, M; Huber, N; Leskelä, S; Natunen, T; Remes, AM; Rostalski, H; Takalo, M1
Bar-Klein, G; Friedman, A; Hameed, MQ; Jozwiak, S; Kaminski, RM; Klein, P; Klitgaard, H; Koepp, M; Löscher, W; Prince, DA; Rotenberg, A; Twyman, R; Vezzani, A; Wong, M1
Chen, J; Liu, M; Ma, B; Wang, J; Yang, S; Zeng, L; Zhang, M1

Reviews

3 review(s) available for acetylcysteine and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years.
    Current rheumatology reports, 2016, Volume: 18, Issue:12

    Topics: Acetylcysteine; B-Lymphocytes; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Sirolimus; T-Lymphocytes; TOR Serine-Threonine Kinases

2016
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
    Epilepsia, 2020, Volume: 61, Issue:3

    Topics: Acetylcysteine; Animals; Anticonvulsants; Antioxidants; Atorvastatin; Brain Injuries, Traumatic; Ceftriaxone; Dibenzazepines; Drug Repositioning; Epilepsy; Epilepsy, Post-Traumatic; Erythropoietin; Fingolimod Hydrochloride; GABA Agents; Gabapentin; Humans; Immunologic Factors; Inflammation; Interleukin 1 Receptor Antagonist Protein; Isoflurane; Levetiracetam; Losartan; Neuroprotective Agents; Oxidative Stress; Pregabalin; Pyrrolidinones; Sirolimus; Stroke; Topiramate; Translational Research, Biomedical; Vigabatrin

2020

Other Studies

33 other study(ies) available for acetylcysteine and sirolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:6

    Topics: 3T3 Cells; Acetylcysteine; Adenoviridae; Adipocytes; Animals; Cell Line; Cysteine Endopeptidases; Deoxyglucose; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression; Humans; Insulin; Insulin Receptor Substrate Proteins; Kidney; Mice; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; Sirolimus; Transfection

2000
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
    Molecular and cellular biology, 2001, Volume: 21, Issue:15

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cytosol; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Glucose; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tyrosine

2001
N-acetyl-cysteine abolishes hydrogen peroxide-induced modification of eukaryotic initiation factor 4F activity via distinct signalling pathways.
    Cellular signalling, 2006, Volume: 18, Issue:1

    Topics: Acetylcysteine; Animals; Carrier Proteins; Eukaryotic Initiation Factor-4F; Eukaryotic Initiation Factor-4G; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; Okadaic Acid; PC12 Cells; Phosphoproteins; Pyridines; Rats; Signal Transduction; Sirolimus

2006
[Diffuse lung diseases].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2006, Jun-10, Volume: 95, Issue:6

    Topics: Acetylcysteine; Autoantibodies; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Lithiasis; Lung Diseases, Interstitial; Pulmonary Alveolar Proteinosis; Pulmonary Alveoli; Sirolimus

2006
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:9

    Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2006
Late experimental amebic liver abscess in hamster is inhibited by cyclosporine and N-acetylcysteine.
    Experimental and molecular pathology, 2007, Volume: 82, Issue:3

    Topics: Acetylcysteine; Animals; Antiviral Agents; Cricetinae; Cyclosporine; Entamoeba histolytica; Immunosuppression Therapy; Immunosuppressive Agents; Liver Abscess, Amebic; Sirolimus; Tacrolimus

2007
Analysis of programmed cell death in mouse fetal oocytes.
    Reproduction (Cambridge, England), 2007, Volume: 134, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Autophagy; Caspase Inhibitors; Cell Culture Techniques; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA Fragmentation; Female; Fetus; Glycoproteins; Immunosuppressive Agents; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Meiotic Prophase I; Mice; Mice, Inbred Strains; Microscopy, Electron, Transmission; Necrosis; Oligopeptides; Oocytes; Ovary; Sirolimus; Stem Cell Factor

2007
Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:11

    Topics: Acetylcysteine; Antioxidants; Catalase; Cells, Cultured; Free Radical Scavengers; Humans; Hydrogen Peroxide; I-kappa B Proteins; Interleukin-6; Interleukin-8; Keratinocytes; Male; Protein Kinases; Psoriasis; Reactive Oxygen Species; Signal Transduction; Sirolimus; Skin Diseases; Taurine; TOR Serine-Threonine Kinases; Transcription Factor RelA; Tumor Necrosis Factor-alpha

2008
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement.
    Neurobiology of disease, 2008, Volume: 32, Issue:1

    Topics: Acetylcysteine; Animals; Autophagy; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Protein Folding; Rats; Sirolimus

2008
Proliferation signal inhibitor-induced decrease of vascular endothelial cadherin expression and increase of endothelial permeability in vitro are prevented by an anti-oxidant.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2008, Volume: 27, Issue:12

    Topics: Acetylcysteine; Cadherins; Cell Division; Cell Membrane Permeability; Endothelium, Vascular; Everolimus; Free Radical Scavengers; Humans; Oxidative Stress; Permeability; Signal Transduction; Sirolimus; Umbilical Veins

2008
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:2

    Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Autophagy; Cells, Cultured; Cytoprotection; Enzyme Inhibitors; Glutathione; Hydrogen Peroxide; Imidazoles; Lipopolysaccharides; Mice; Mice, Transgenic; Mitochondria, Heart; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Tyrphostins

2009
An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity.
    Autophagy, 2009, Volume: 5, Issue:5

    Topics: Acetylcysteine; Apoptosis; Autophagy; Cell Line, Tumor; Cytoprotection; Dopamine; Enzyme Inhibitors; Humans; Mitochondria; Nerve Degeneration; Neurons; Phagosomes; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Sirolimus; Time Factors; Tumor Suppressor Protein p53

2009
Combined treatment with antioxidants and immunosuppressants on cytokine release by human peripheral blood mononuclear cells - chemically injured keratocyte reaction.
    Molecular vision, 2011, Volume: 17

    Topics: Acetylcysteine; Antioxidants; Burns, Chemical; Cells, Cultured; Coculture Techniques; Cornea; Corneal Injuries; Corneal Keratocytes; Dexamethasone; Drug Combinations; Humans; Immunosuppressive Agents; Interleukin-6; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Macrophage Migration-Inhibitory Factors; Matrix Metalloproteinase 9; Mycophenolic Acid; Sirolimus; Sodium Hydroxide; Thioctic Acid; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2011
Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells.
    Biochimica et biophysica acta, 2012, Volume: 1822, Issue:11

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; AMP-Activated Protein Kinases; Apoptosis; Autophagy; Cell Line; Gene Expression Regulation; Humans; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neuroblastoma; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; Sequestosome-1 Protein; Sirolimus; TOR Serine-Threonine Kinases

2012
High glucose induces autophagy in podocytes.
    Experimental cell research, 2013, Apr-01, Volume: 319, Issue:6

    Topics: Acetylcysteine; Adenine; Animals; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blood Glucose; Catalase; Culture Media; Diabetes Mellitus, Experimental; Glucose; Male; Microscopy, Electron; Microtubule-Associated Proteins; Podocytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Streptozocin; Superoxide Dismutase; Tumor Cells, Cultured

2013
Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty.
    Proceedings of the National Academy of Sciences of the United States of America, 2014, Mar-25, Volume: 111, Issue:12

    Topics: Acetylcysteine; Animals; Anisomycin; Behavior, Animal; Calcium Channel Blockers; Conditioning, Classical; Excitatory Amino Acid Antagonists; Fear; Hippocampus; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Rats; Sirolimus; Ubiquitin

2014
Autophagy attenuates noise-induced hearing loss by reducing oxidative stress.
    Antioxidants & redox signaling, 2015, May-20, Volume: 22, Issue:15

    Topics: Acetylcysteine; Aldehydes; Animals; Antioxidants; Autophagy; Hair Cells, Auditory, Outer; Hearing Loss, Noise-Induced; Male; Mice; Microtubule-Associated Proteins; Oxidative Stress; Sirolimus; Tyrosine

2015
The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation.
    Aging cell, 2015, Volume: 14, Issue:4

    Topics: Acetylcysteine; Antioxidants; Autophagy; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cellular Senescence; Gene Expression Regulation; Humans; Interleukin-6; Interleukin-8; Mesenchymal Stem Cells; Mitochondria; nef Gene Products, Human Immunodeficiency Virus; NF-kappa B; Osteoblasts; Osteocalcin; Oxidative Stress; Primary Cell Culture; Recombinant Proteins; Sesquiterpenes; Signal Transduction; Sirolimus; tat Gene Products, Human Immunodeficiency Virus

2015
Liver injury correlates with biomarkers of autoimmunity and disease activity and represents an organ system involvement in patients with systemic lupus erythematosus.
    Clinical immunology (Orlando, Fla.), 2015, Volume: 160, Issue:2

    Topics: Acetylcysteine; Adult; Alanine Transaminase; Antibodies, Antinuclear; Aspartate Aminotransferases; Azathioprine; Biomarkers; Cohort Studies; Complement System Proteins; Cyclosporine; Diabetes Mellitus; Female; Free Radical Scavengers; Humans; Immunosuppressive Agents; Liver Diseases; Longitudinal Studies; Lupus Erythematosus, Systemic; Male; Middle Aged; Mycophenolic Acid; Prednisone; Prevalence; Retrospective Studies; Severity of Illness Index; Sex Distribution; Sirolimus

2015
The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism.
    Cell stem cell, 2016, Feb-04, Volume: 18, Issue:2

    Topics: Acetylcysteine; Animals; Antigens, CD; Calcium-Binding Proteins; Fetus; Genetic Loci; Genomic Imprinting; HEK293 Cells; Hematopoietic Stem Cells; Humans; Intercellular Signaling Peptides and Proteins; Liver; Mice, Inbred C57BL; MicroRNAs; Mitochondria; Mutation; Organelle Biogenesis; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; RNA, Long Noncoding; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2016
Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease.
    Journal of autoimmunity, 2016, Volume: 75

    Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Autophagy-Related Proteins; Caspase 3; Cell Line; Epithelial Cells; Hashimoto Disease; Humans; Immunoblotting; Immunohistochemistry; Iodine; Reactive Oxygen Species; Sirolimus; Thyroid Gland; Transforming Growth Factor beta1

2016
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
    Cell death and differentiation, 2017, Volume: 24, Issue:2

    Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases

2017
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 44

    Topics: Acetylcysteine; Adenine; Autophagy; Cell Line; Cell Survival; Diethylhexyl Phthalate; Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Sirolimus

2017
Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis.
    Stem cell research, 2017, Volume: 23

    Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Line; Glycogen Synthase Kinase 3; Humans; Induced Pluripotent Stem Cells; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Sirolimus; Sulfhydryl Compounds; TOR Serine-Threonine Kinases

2017
Autophagy protects auditory hair cells against neomycin-induced damage.
    Autophagy, 2017, Volume: 13, Issue:11

    Topics: Acetylcysteine; Adenine; Animals; Anti-Bacterial Agents; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Line; Hair Cells, Auditory; Mice; Mitochondria; Neomycin; Reactive Oxygen Species; Sirolimus

2017
Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:12

    Topics: Acetylcysteine; Biomarkers; Cellular Senescence; Cyclic N-Oxides; Down-Regulation; Etoposide; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Lung; Mitochondria; Myofibroblasts; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rotenone; Sirolimus

2018
ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 50, Issue:5

    Topics: Acetylcysteine; Adenine; Autophagy; Beclin-1; Blood Platelets; Cell Adhesion; Humans; Lipoproteins, LDL; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2018
Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway.
    Molecular medicine reports, 2019, Volume: 19, Issue:2

    Topics: Acetylcysteine; Anti-Inflammatory Agents; Antioxidants; Cell Line; Chromones; Curcumin; Diabetic Retinopathy; Drug Synergism; Epithelial Cells; Gene Expression Regulation; Glucose; Humans; Interleukin-1beta; Interleukin-6; Models, Biological; Morpholines; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Retinal Pigment Epithelium; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2019
NF-κB/mTOR-mediated autophagy can regulate diquat-induced apoptosis.
    Archives of toxicology, 2019, Volume: 93, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Autophagy; Cell Survival; Diquat; Dose-Response Relationship, Drug; Herbicides; Neurotoxicity Syndromes; NF-kappa B; PC12 Cells; Rats; Reactive Oxygen Species; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases

2019
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
    Cytokine, 2020, Volume: 125

    Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scavengers; Inflammation; Interleukin-6; Mice; Microtubule-Associated Proteins; Muscle, Skeletal; Oxidative Stress; Palmitates; Reactive Oxygen Species; Sequestosome-1 Protein; Sirolimus; Tumor Necrosis Factor-alpha

2020
C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner.
    Cells, 2019, 10-10, Volume: 8, Issue:10

    Topics: Acetylcysteine; Animals; Autophagosomes; Autophagy; C9orf72 Protein; Cell Line; Gene Expression Regulation; Gene Knockout Techniques; Macrolides; Mice; Neurons; Organ Specificity; Proteasome Endopeptidase Complex; Proteolysis; Sirolimus

2019
Role of autophagy in lysophosphatidylcholine-induced apoptosis in mouse Leydig cells.
    Environmental toxicology, 2022, Volume: 37, Issue:11

    Topics: Acetylcysteine; Animals; Apoptosis; Autophagy; Glycerophospholipids; Leydig Cells; Lysophosphatidylcholines; Male; Mice; Oxidative Stress; Sirolimus

2022