acetylcysteine has been researched along with sb 203580 in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.16) | 18.2507 |
| 2000's | 33 (38.37) | 29.6817 |
| 2010's | 51 (59.30) | 24.3611 |
| 2020's | 1 (1.16) | 2.80 |
| Authors | Studies |
|---|---|
| Joe, E; Jou, I; Jung, S; Lee, SH; Pyo, H | 1 |
| Gon, Y; Hashimoto, S; Horie, T; Jibiki, I; Kudoh, S; Matsumoto, K; Takeshita, I; Takizawa, H | 1 |
| Chen, KD; Chen, LY; Cho, JH; Lai, MT; Lai, YK | 1 |
| Horwitz, KB; Lange, CA; Shen, T | 1 |
| Gon, Y; Hashimoto, S; Horie, T; Kujime, K; Shimizu, K | 1 |
| Cohen, GM; Dickens, M; MacFarlane, M | 1 |
| Asai, Y; Gon, Y; Hashimoto, S; Horie, T; Machino, T; Matsumoto, K; Takeshita, I | 1 |
| Joe, E; Jou, I; Pyo, H; Ryu, J | 1 |
| Ahn, HJ; Fujiwara, H; Hamaoka, T; Kurimoto, M; Nakahira, M; Ohta, T; Park, CS; Park, WR; Sugimoto, N | 1 |
| Grant, S; Vrana, JA | 1 |
| Desaki, M; Kasama, T; Kawasaki, S; Kobayashi, K; Nakahara, K; Ohtoshi, T; Okazaki, H; Sagai, M; Takami, K; Takizawa, H; Tanaka, M; Yamamoto, K | 1 |
| Ho, YS; Lee, HM; Lin, CH; Thum, WY; Wu, CH | 1 |
| Abe, S; Hasegawa, T; Kirima, K; Kyaw, M; Suzaki, Y; Tamaki, T; Tsuchiya, K; Yoshizumi, M | 1 |
| Dobashi, K; Ishizuka, T; Kawata, T; Mori, M; Shimizu, Y; Tsukagoshi, H | 1 |
| Griendling, KK; Rocic, P; Seshiah, P | 1 |
| Guo, ZJ; Hou, FF; Liang, M; Liu, ZQ; Wang, L; Zhang, X | 1 |
| Hebert, C; Nikitakis, NG; Norris, K; Sauk, JJ; Siavash, H; Stewart, J | 1 |
| Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H | 1 |
| He, D; Natarajan, V; Parinandi, NL; Usatyuk, PV; Vepa, S; Watkins, T | 1 |
| Cho, D; Hahm, E; Hur, D; Hwang, YI; Kang, JS; Kim, D; Kim, S; Kim, YI; Kim, YS; Lee, WJ; Pang, S; Park, H; Park, JH; Yang, Y | 1 |
| Martín, ME; O'Loghlen, A; Pérez-Morgado, MI; Salinas, M | 1 |
| Allshire, A; Anoopkumar-Dukie, S; Carey, JB; Conere, T | 1 |
| Kim, IS; Park, SJ | 1 |
| Becker, TC; Cao, W; Collins, QF; Collins, S; Daniel, KW; Floering, L; Lupo, EG; Robidoux, J; Xiong, Y | 1 |
| Bark, H; Choi, CH; Chung, JM; Kim, SH; Park, EK | 1 |
| Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N | 1 |
| Borowitz, JL; Isom, GE; Li, L; Liu, H; Prabhakaran, K; Zhang, L; Zhang, X | 1 |
| Kim, JA; Kim, JY; Kwak, MK; Lee, YS; Park, BC; Park, HJ; Yoo, BK | 1 |
| Fanjul-Moles, ML; Gonsebatt, ME; Hernández, NA; Limón-Pacheco, JH | 1 |
| Arai, F; Gomei, Y; Hosokawa, K; Ito, K; Iwasaki, H; Miyamoto, K; Nakamura, Y; Shima, H; Suda, T; Yoshihara, H | 1 |
| Chilian, WM; Dick, GM; Kiyooka, T; Park, Y; Rocic, P; Rogers, PA; Saitoh, S; Swafford, A; Viswanathan, C; Zhang, C | 1 |
| Carreira, RS; Glembotski, CC; Gottlieb, RA; Huang, C; Iwai-Kanai, E; Perry, CN; Yuan, H | 1 |
| Banerjee Mustafi, S; Chakraborty, PK; Dey, RS; Raha, S | 1 |
| Lee, WY; Liu, KW; Yeung, JH | 1 |
| Breysse, PN; Chiang, ET; Chillrud, SN; Garcia, JG; Geyh, AS; Lang, GD; Moreno-Vinasco, L; Natarajan, V; Pendyala, S; Samet, JM; Wang, T | 1 |
| Aiba, S; Hirota, M; Itagaki, H; Kagatani, S; Mizuashi, M; Ohtani, T; Sasaki, Y; Suzuki, M | 1 |
| Chang, JW; Han, NJ; Kim, YJ; Lee, JM; Park, SK; Yang, WS | 1 |
| Cheng, ML; Cheng, TH; Chiu, DT; Ho, HY; Lin, CJ; You, TH; Yu, JS | 1 |
| Agrawal, M; Bala Bhaskar, AS; Gupta, N; Lakshmana Rao, PV; Ravindran, J | 1 |
| Li, J; Liu, XT; Shang, FJ; Wang, JP; Xue, YS; Zhao, LY; Zheng, QS | 1 |
| Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C | 1 |
| Han, C; Li, M; Liu, J; Mao, J; Pang, X; Wang, B | 1 |
| Haddad, JJ | 1 |
| Bedolla, RG; Gao, SJ; Guadalupe, M; Jones, T; Kang, T; Lei, X; Ye, F; Zhou, F | 1 |
| Baumann, S; Böhme, A; Kohajda, T; Lehmann, I; Mögel, I; Simon, JC; von Bergen, M | 1 |
| Liu, L; Lou, Y; Wang, J; Xiao, Y; Zou, J; Zou, P | 1 |
| Capasso, A; D'Acunto, CW; Festa, M; Masullo, M; Piacente, S; Pizza, C; Rossi, AG | 1 |
| Sun, HX; Yu, DJ; Yu, M; Zheng, Y | 1 |
| Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC | 1 |
| Cha, JH; Cha, SH; Cho, WH; Choi, CH; Choi, YJ | 1 |
| Dahmer, MK; Park, SK; Quasney, MW | 1 |
| Grune, T; Kästle, M; Woschee, E | 1 |
| Radhika, A; Sudhakaran, PR | 1 |
| Furtak, T; Gauthier, ER; Guerin, PJ; Harnett, CC | 1 |
| Chang, YC; Huang, FM; Kuan, YH; Lee, SS; Tsai, CH | 1 |
| Hwangbo, C; Kim, N; Lee, JH; Lee, S | 1 |
| Feng, J; Guo, R; Lin, J; Mo, L; Shen, N; Xu, W; Zhang, C | 1 |
| Chenyang, J; Jiajing, W; Jianchun, B; Jianhong, G; Xuezhong, L; Yan, Y; Yiran, Z; Zongping, L | 1 |
| Handa, K; Ishida, H; Katsuta, H; Kitahara, A; Miyokawa-Gorin, K; Moriya, R; Nishida, S; Ohno, H; Onuma, H; Sumitani, Y; Takahashi, K; Tanaka, T; Yoshimoto, K | 1 |
| Kim, SJ; Yu, SM | 1 |
| Li, Q; Liu, X; Wang, H; Wang, J; Xiao, S; Xie, Y; Ye, S | 1 |
| Hsu, A; Kumar, AP; Sethi, G; Tan, KH; Woo, CC | 1 |
| Chen, J; Guo, R; Huang, R; Li, S; Tian, L; Wu, K; Yan, H; You, Q | 1 |
| Kayama, T; Kitanaka, C; Narita, Y; Okada, M; Sato, A; Seino, S; Shibui, S; Shibuya, K; Watanabe, E | 1 |
| Kim, GT; Kim, JI; Kim, YM; Lee, SH | 1 |
| Chen, Q; Song, J; Wei, Y; Xing, D | 1 |
| Bao, JF; Hao, J; Hong, FY; Liu, J; Yu, Q | 1 |
| Huang, YX; Jian, D; Li, J; Li, WZ; Shi, W; Wang, B; Xie, HF | 1 |
| Beccafico, S; Donato, R; Marchetti, MC; Morozzi, G; Riccardi, C; Sidoni, A; Sorci, G | 1 |
| Yang, ML; Ye, ZM | 1 |
| Lu, M; Zhang, Q; Zhao, W | 1 |
| Cao, L; Chen, X; Li, W; Ma, Q; Xiao, X | 1 |
| Gao, HW; He, YY; Khan, M; Li, YM; Ma, TH; Yang, JB; Yao, M | 1 |
| Eder, C; Miralles, F; Schilling, T; Spencer, NG | 1 |
| Li, BW; Li, Z; Tang, J; Tao, JQ; Wang, JW; Wang, LJ; Wang, WZ; Wei, S; Xie, KL; Xu, H; Xu, ZK; Yang, L; Zhang, DC; Zhang, Q; Zhi, XF; Zhu, Y | 1 |
| Chen, J; Cheng, F; Feng, J; Lan, J; Lei, Y; Mei, W; Xu, Q; Zeng, B; Zhai, Y; Zhang, W; Zhen, Y; Zheng, D | 1 |
| Huang, D; Lin, B; Liu, S; Liu, Y; Wang, K; Wu, W; Yu, C; Zhang, H | 1 |
| Chen, JX; Ding, KF; Du, CJ; Gao, F; Hu, SM; Li, SJ; Li, Y; Mao, XW; Miyamoto, H; Wen, JM; Zhang, N; Zhang, SG | 1 |
| Al Mamun Bhuyan, A; Bissinger, R; Cao, H; Lang, F | 1 |
| Hong, L; Huang, Z; Li, H; Miao, B; Na, N; Zhang, J; Zhao, D | 1 |
| Lee, CS; Nam, YJ | 1 |
| Liu, C; Yang, M; Zeng, L; Zhang, P | 1 |
| Feng, B; Jin, X; Lu, X; Qin, H; Shi, L; Wang, H; Wang, R; Yang, X; Yu, D | 1 |
| Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D | 1 |
| Li, X; Liu, F; Luo, J; Yang, H; Yang, Y; Zhao, Q | 1 |
| Katome, T; Kobayashi, T; Kojima, M; Matsumoto, T; Taguchi, K; Takayanagi, K | 1 |
86 other study(ies) available for acetylcysteine and sb 203580
| Article | Year |
|---|---|
Gangliosides activate cultured rat brain microglia.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Brain; Culture Techniques; Cyclooxygenase 2; Enzyme Inhibitors; Flavonoids; Gangliosides; Imidazoles; Isoenzymes; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; Mitogen-Activated Protein Kinases; Neuraminidase; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 1999 |
Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation.
Topics: Acetylcysteine; Blotting, Western; Bronchi; Cells, Cultured; Chemokine CCL5; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Humans; Imidazoles; Interleukin-8; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Threonine; Tyrosine; Vehicle Emissions | 2000 |
Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A.
Topics: Acetylcysteine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Egtazic Acid; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Heat-Shock Proteins; Imidazoles; Marine Toxins; Mitochondria; Mitogen-Activated Protein Kinases; Molecular Chaperones; Okadaic Acid; Oxazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Proline; Promoter Regions, Genetic; Pyridines; Rats; RNA, Messenger; Ruthenium Red; Thiocarbamates; Transcriptional Activation; Tumor Cells, Cultured | 2000 |
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins | 2000 |
p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells.
Topics: Acetylcysteine; Bronchi; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; Chemokine CCL5; Cytokines; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Indoles; Influenza A virus; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2000 |
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; T-Lymphocytes; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2000 |
Regulation by intracellular glutathione of TNF-alpha-induced p38 MAP kinase activation and RANTES production by human pulmonary vascular endothelial cells.
Topics: Acetylcysteine; Buthionine Sulfoximine; Cells, Cultured; Chemokine CCL5; Endothelium, Vascular; Glutathione; Humans; Imidazoles; Immunoblotting; Lung; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Pyridines; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B.
Topics: Acetylcysteine; Animals; Carbazoles; Cells, Cultured; Cerebral Cortex; Enzyme Induction; Flavonoids; Imidazoles; Indoles; Maleimides; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thrombin | 2000 |
Differential effects of N-acetyl-l-cysteine on IL-2- vs IL-12-driven proliferation of a T cell clone: implications for distinct signalling pathways.
Topics: Acetylcysteine; Animals; Cell Division; Cell Line; Dexamethasone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Imidazoles; Interleukin-12; Interleukin-2; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Precipitin Tests; Pyridines; Recombinant Proteins; Signal Transduction; T-Lymphocytes | 2000 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells.
Topics: Acetylcysteine; Antioxidants; Benzene; Bronchi; Cell Line; Chemokine CCL5; Enzyme Inhibitors; Epithelial Cells; Free Radical Scavengers; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; In Vitro Techniques; Interleukin-8; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrrolidines; RNA, Messenger; T-Lymphocytes; Thiocarbamates; Vehicle Emissions | 2001 |
Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Glycation End Products, Advanced; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Polylysine; Polymyxin B; Prostaglandin-Endoperoxide Synthases; Pyridines; Reactive Oxygen Species | 2002 |
Antioxidants inhibit endothelin-1 (1-31)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1).
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Cell Division; Cyclic N-Oxides; DNA; Dose-Response Relationship, Drug; Endothelin-1; Endothelins; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Transcription Factor AP-1 | 2002 |
4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.
Topics: Acetylcysteine; Aldehydes; Cell Line; Culture Media, Conditioned; ErbB Receptors; Fibroblasts; Fibronectins; Humans; Imidazoles; Lipid Peroxidation; Lung; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pyridines; Quinazolines; Signal Transduction; Tyrphostins | 2002 |
Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.
Topics: Acetylcysteine; Angiotensin II; Animals; Aorta; Azoles; Blotting, Western; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Genes, Dominant; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Muscle, Smooth, Vascular; Okadaic Acid; Onium Compounds; Organoselenium Compounds; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Pyridines; Rats; Reactive Oxygen Species; Serine; Threonine; Time Factors | 2003 |
[Advanced glycation end products stimulate human endothelial cells to produce monocyte chemoattractant protein-1].
Topics: Acetylcysteine; Cells, Cultured; Chemokine CCL2; Endothelial Cells; Glycation End Products, Advanced; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Serum Albumin; Serum Albumin, Bovine; Serum Albumin, Human | 2003 |
Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells.
Topics: Acetylcysteine; Androstadienes; Antimutagenic Agents; Biomarkers; Cell Hypoxia; Cell Line, Tumor; Cobalt; Collagen Type XVIII; Enzyme Inhibitors; Head and Neck Neoplasms; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Humans; Imidazoles; MAP Kinase Signaling System; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Vascular Endothelial Growth Factor A; Wortmannin | 2003 |
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins | 2003 |
Redox regulation of reactive oxygen species-induced p38 MAP kinase activation and barrier dysfunction in lung microvascular endothelial cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutathione; Hydrogen Peroxide; Imidazoles; Lung; MAP Kinase Signaling System; Microcirculation; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Permeability; Pyridines; Reactive Oxygen Species; Time Factors | 2003 |
Vitamin C downregulates interleukin-18 production by increasing reactive oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine melanoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Cell Line, Tumor; Densitometry; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; Imidazoles; Immunoprecipitation; Interleukin-18; MAP Kinase Signaling System; Melanoma; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skin Neoplasms; Time Factors | 2003 |
N-acetyl-cysteine abolishes hydrogen peroxide-induced modification of eukaryotic initiation factor 4F activity via distinct signalling pathways.
Topics: Acetylcysteine; Animals; Carrier Proteins; Eukaryotic Initiation Factor-4F; Eukaryotic Initiation Factor-4G; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; Okadaic Acid; PC12 Cells; Phosphoproteins; Pyridines; Rats; Signal Transduction; Sirolimus | 2006 |
Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines.
Topics: Acetylcysteine; Anthracenes; Antioxidants; Apoptosis; Ascorbic Acid; Butadienes; Cell Line, Tumor; Cell Proliferation; DNA Damage; Enzyme Inhibitors; Fluoresceins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Melatonin; Mitochondria; Nitriles; Nitrites; Oxazines; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Radiation Tolerance; Rhodamines; Spectrometry, Fluorescence; Xanthenes | 2005 |
The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells.
Topics: Acetylcysteine; Antioxidants; Antirheumatic Agents; Apoptosis; Auranofin; Caspases; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Time Factors | 2005 |
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
Topics: Acetylcysteine; Adenoviridae; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 1; Disease Models, Animal; Enzyme Inhibitors; Gene Silencing; Glucagon; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Promoter Regions, Genetic; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Streptozocin; Trans-Activators; Transcription Factors; Transfection | 2005 |
Elevated reactive oxygen species but not glutathione regulate mercury resistance to AML-2/DX100 cells.
Topics: Acetylcysteine; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Hydrogen Peroxide; Imidazoles; Mercuric Chloride; Multidrug Resistance-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Probenecid; Pyridines; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Thiocarbamates | 2006 |
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adrenergic Agents; Animals; Cell Nucleus; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Glutathione; Hydrogen Peroxide; Imidazoles; Models, Biological; NF-E2 Transcription Factor; Oxidants; Oxidative Stress; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Ubiquitin | 2007 |
HIF-1alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death.
Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cyanides; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mitochondria; Oxidation-Reduction; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Pyridines; Rats; Reactive Oxygen Species; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic; Up-Regulation | 2007 |
Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death.
Topics: Acetylcysteine; Apoptosis; Calcium; Caspase 3; Cell Death; Cell Line, Tumor; Cytoprotection; Egtazic Acid; Enzyme Activation; Flavonoids; Humans; Imidazoles; Neurons; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Rhus; Signal Transduction | 2007 |
Glutathione depletion activates mitogen-activated protein kinase (MAPK) pathways that display organ-specific responses and brain protection in mice.
Topics: Acetylcysteine; Activating Transcription Factor 2; Animals; Antioxidants; Brain; Butadienes; Buthionine Sulfoximine; Glutathione; Imidazoles; Kidney; Liver; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; NF-kappa B; Nitriles; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pyridines; Reactive Oxygen Species; Sulfhydryl Compounds | 2007 |
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction.
Topics: Acetylcysteine; Animals; Bone Marrow Cells; Cadherins; Cell Count; Cells, Cultured; Enzyme Inhibitors; Flow Cytometry; Fluorouracil; Free Radical Scavengers; Gene Expression; Hematopoietic Stem Cells; Imidazoles; Immunohistochemistry; Mice; Mice, Inbred C57BL; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
Redox-dependent coronary metabolic dilation.
Topics: Acetylcysteine; Animals; Antioxidants; Coronary Vessels; Culture Media, Conditioned; Dithiothreitol; Enzyme Activation; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; Microscopy, Fluorescence; Myocytes, Cardiac; Nitroprusside; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Reducing Agents; Sulfhydryl Compounds; Vasodilation; Vasodilator Agents | 2007 |
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Autophagy; Cells, Cultured; Cytoprotection; Enzyme Inhibitors; Glutathione; Hydrogen Peroxide; Imidazoles; Lipopolysaccharides; Mice; Mice, Transgenic; Mitochondria, Heart; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Tyrphostins | 2009 |
Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt.
Topics: Acetylcysteine; Animals; Cell Line; Cricetinae; Cricetulus; DNA-Binding Proteins; Fibroblasts; Free Radical Scavengers; Heat Shock Transcription Factors; Heat-Shock Response; HSP70 Heat-Shock Proteins; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase; Transcription Factors; Up-Regulation | 2009 |
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors | 2009 |
Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways.
Topics: Acetylcysteine; Air Pollutants; Antioxidants; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Lung; Lung Diseases; Molecular Chaperones; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Particulate Matter; Phosphorylation; Pyridines; Reactive Oxygen Species | 2010 |
Oxidation of cell surface thiol groups by contact sensitizers triggers the maturation of dendritic cells.
Topics: Acetylcysteine; Animals; Cells, Cultured; Dendritic Cells; Drug Interactions; Enzyme Inhibitors; Epidermal Cells; Epidermis; Female; Flow Cytometry; Free Radical Scavengers; Haptens; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Monocytes; Oxidants; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phenanthrolines; Phosphorylation; Pyridines; Sulfhydryl Compounds | 2010 |
Mycophenolic acid attenuates tumor necrosis factor-alpha-induced endothelin-1 production in human aortic endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mycophenolic Acid; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2010 |
Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Dual Specificity Phosphatase 1; Flavonoids; Gene Knockdown Techniques; Glucosephosphate Dehydrogenase; Hep G2 Cells; Humans; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Pyridines | 2010 |
Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase 7; Caspase 9; Cell Line, Tumor; Cyclosporins; Cytochromes c; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Reactive Oxygen Species; U937 Cells | 2011 |
[The relationship between reactive oxygen species-dependent activation of p38 MAPK and the expression of tumor necrosis factor-α in cultured cardiomyocytes].
Topics: Acetylcysteine; Animals; Female; Imidazoles; Lipopolysaccharides; Male; Myocytes, Cardiac; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species | 2011 |
Angiotensin II induces the expression of c-reactive protein via MAPK-dependent signal pathway in U937 macrophages.
Topics: Acetylcysteine; Angiotensin II; Antihypertensive Agents; C-Reactive Protein; Flavonoids; Humans; Imidazoles; Losartan; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proline; Pyridines; Thiocarbamates; U937 Cells | 2011 |
A redox microenvironment is essential for MAPK-dependent secretion of pro-inflammatory cytokines: modulation by glutathione (GSH/GSSG) biosynthesis and equilibrium in the alveolar epithelium.
Topics: Acetylcysteine; Alveolar Epithelial Cells; Buthionine Sulfoximine; Cells, Cultured; Enzyme Activation; Glutamate-Cysteine Ligase; Glutathione Disulfide; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; MAP Kinase Signaling System; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pulmonary Alveoli; Pyridines; Tumor Necrosis Factor-alpha | 2011 |
Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency.
Topics: Acetylcysteine; Animals; Blotting, Western; Butadienes; Catalase; Cell Line; Fluorescent Antibody Technique; Glutathione; HEK293 Cells; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma, Kaposi; Signal Transduction; Virus Activation; Virus Latency; Virus Replication | 2011 |
The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation.
Topics: Acetylcysteine; Air Pollutants; Benzene Derivatives; Blotting, Western; Cell Line; Cyclooxygenase 2; Dinoprost; Dinoprostone; Enzyme Activation; Enzyme Induction; Epithelial Cells; Glutathione; Humans; Imidazoles; Lung; MAP Kinase Kinase Kinases; Oxidative Stress; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines | 2011 |
The cross-talk between ROS and p38MAPKα in the Ex Vivo expanded human umbilical cord blood CD133(+) cells.
Topics: AC133 Antigen; Acetylcysteine; Antigens, CD; Cell Division; Cells, Cultured; Culture Media; Fetal Blood; Glycoproteins; Hematopoietic Stem Cells; Humans; Imidazoles; Mitogen-Activated Protein Kinase 14; Peptides; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species | 2011 |
Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cyclohexenes; Cytochromes c; Dose-Response Relationship, Drug; Flavonoids; Glioblastoma; Humans; Imidazoles; Italy; Mitogen-Activated Protein Kinases; Molecular Structure; Poly(ADP-ribose) Polymerases; Propiophenones; Pyridines; Reactive Oxygen Species; Terpenes | 2011 |
Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS/P38MAPK/TGF-β1 signaling pathway.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Enalaprilat; Fibroblasts; Gene Expression; Imidazoles; MAP Kinase Signaling System; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Plant Extracts; Pyridines; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Transforming Growth Factor beta1 | 2012 |
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxygenase 2 Inhibitors; Down-Regulation; Female; Flavonoids; Gene Expression; Gene Expression Regulation, Neoplastic; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mouth Neoplasms; Nitrobenzenes; Pyridines; Quercetin; Sulfonamides | 2012 |
Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Butadienes; Caspases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Disulfides; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Imidazoles; MAP Kinase Signaling System; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridines; Sulfinic Acids | 2012 |
MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes.
Topics: Acetylcysteine; Antioxidants; ATP-Binding Cassette Transporters; Butadienes; Cell Line, Tumor; DNA-Binding Proteins; Humans; Hydrogen Peroxide; Imidazoles; Janus Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein D; Pyridines; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Transcription Factors; Tyrphostins | 2012 |
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
Topics: Acetylcysteine; Cell Survival; Cells, Cultured; Enzyme Induction; Gene Expression; Gene Knockdown Techniques; Heme Oxygenase-1; Histone Deacetylase 6; Histone Deacetylases; Homeostasis; HSP70 Heat-Shock Proteins; Humans; Imidazoles; MAP Kinase Signaling System; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyridines; RNA, Small Interfering; Ubiquitin-Activating Enzymes | 2012 |
Upregulation of macrophage-specific functions by oxidized LDL: lysosomal degradation-dependent and -independent pathways.
Topics: Acetylcysteine; Cell Differentiation; Cells, Cultured; Chloroquine; Chromones; Copper Sulfate; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression; Humans; Imidazoles; Leukocytes, Mononuclear; Lipoproteins, LDL; Lysosomes; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Naphthalenes; NF-kappa B; Oxidation-Reduction; PPAR gamma; Proteolysis; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation | 2013 |
Control of late apoptotic events by the p38 stress kinase in L-glutamine-deprived mouse hybridoma cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-X Protein; Caspase Inhibitors; Enzyme Activation; Gene Expression Regulation; Glutamine; Hybridomas; Imidazoles; Mice; Mitochondria; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction | 2013 |
The upregulation of transglutaminase-2 by cyclosporin a in human gingival fibroblasts is augmented by oxidative stress.
Topics: Acetylcysteine; Adult; Antioxidants; Catechin; Cell Culture Techniques; Cells, Cultured; Chromones; Curcumin; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Free Radical Scavengers; Gingiva; GTP-Binding Proteins; Humans; Imidazoles; Immunosuppressive Agents; Male; Morpholines; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protease Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyridines; Reactive Oxygen Species; Transglutaminases; Up-Regulation | 2013 |
Eupatolide inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through ROS-dependent heme oxygenase-1 induction.
Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Imidazoles; Inula; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Nitriles; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2013 |
Hydrogen sulfide attenuates doxorubicin-induced cardiotoxicity by inhibition of the p38 MAPK pathway in H9c2 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cardiotoxins; Cell Line; Cell Survival; Doxorubicin; Hydrogen Sulfide; Imidazoles; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Myocytes, Cardiac; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Reactive Oxygen Species | 2013 |
Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cadmium; Cell Line; Extracellular Signal-Regulated MAP Kinases; Glutathione Peroxidase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Malondialdehyde; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2013 |
Endogenous oxidative stress, but not ER stress, induces hypoxia-independent VEGF120 release through PI3K-dependent pathways in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Animals; Cell Hypoxia; Chemokine CCL2; Chromones; Endoplasmic Reticulum Stress; Imidazoles; Mice; Morpholines; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Palmitates; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Vascular Endothelial Growth Factor A | 2013 |
Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcysteine; Animals; Anions; Anthracenes; Apoptosis; Benzoquinones; Cartilage, Articular; Cell Proliferation; Cell Survival; Chondrocytes; Enzyme Activation; Free Radical Scavengers; Imidazoles; Intracellular Space; Ion Channels; Mitochondria; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Rabbits; Reactive Oxygen Species; Signal Transduction | 2013 |
Induction of apoptosis and inhibition of invasion in choriocarcinoma JEG-3 cells by α-calendic acid and β-calendic acid.
Topics: Acetylcysteine; alpha-Tocopherol; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cell Movement; Fatty Acids, Unsaturated; Female; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Imidazoles; Lipid Peroxidation; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Signal Transduction; Stereoisomerism | 2013 |
Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Silencing; Humans; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2013 |
Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Flavanones; Fruit; Glucose; Hyperglycemia; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rats; Reactive Oxygen Species | 2014 |
Pivotal role for ROS activation of p38 MAPK in the control of differentiation and tumor-initiating capacity of glioma-initiating cells.
Topics: Acetylcysteine; Animals; Brain Neoplasms; Buthionine Sulfoximine; Cell Differentiation; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Glioma; Humans; Hydrogen Peroxide; Imidazoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 7; Neoplastic Stem Cells; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; RNA Interference; Transplantation, Heterologous | 2014 |
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
Topics: Acetylcysteine; AMP-Activated Protein Kinases; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Humans; Imidazoles; Intracellular Space; MAP Kinase Signaling System; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Quercetin; Reactive Oxygen Species; RNA, Small Interfering; Toluene; Transfection; Tumor Suppressor Protein p53 | 2014 |
Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Female; Humans; Imidazoles; Interleukin-1beta; Light; MCF-7 Cells; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Pyridines; Reactive Oxygen Species; Signal Transduction; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2014 |
Methylglyoxal and advanced glycation end-products promote cytokines expression in peritoneal mesothelial cells via MAPK signaling.
Topics: Acetylcysteine; Cell Line; Cell Proliferation; Chemokine CCL2; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation; Glucose; Glycation End Products, Advanced; Humans; Imidazoles; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Peritoneal Dialysis; Peritoneum; Pyridines; Pyruvaldehyde; Real-Time Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2015 |
Asymmetrical dimethylarginine promotes the senescence of human skin fibroblasts via the activation of a reactive oxygen species-p38 MAPK-microRNA-138 pathway.
Topics: Acetylcysteine; Arginine; Back; Cells, Cultured; Cellular Senescence; Child; Enzyme Inhibitors; Face; Fibroblasts; Free Radical Scavengers; Humans; Imidazoles; MAP Kinase Signaling System; MicroRNAs; Middle Aged; Pyridines; Reactive Oxygen Species; Skin; Skin Aging; Ultraviolet Rays | 2015 |
Artesunate induces ROS- and p38 MAPK-mediated apoptosis and counteracts tumor growth in vivo in embryonal rhabdomyosarcoma cells.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Artemisinins; Artesunate; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; DNA Damage; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Integrin beta1; Mice; MicroRNAs; Neoplasm Invasiveness; Neoplasm Transplantation; Neural Cell Adhesion Molecules; p38 Mitogen-Activated Protein Kinases; PAX7 Transcription Factor; Pyridines; Reactive Oxygen Species; Rhabdomyosarcoma, Embryonal; Transplantation, Heterologous | 2015 |
[Extremely low frequency electromagnetic field induces apoptosis of osteosarcoma cells via oxidative stress].
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cell Proliferation; Electromagnetic Fields; Humans; Imidazoles; Osteosarcoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species | 2015 |
Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Movement; Chloride Channels; Down-Regulation; Glycolates; Humans; Imidazoles; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms | 2015 |
Resveratrol inhibits hyperglycemia-driven ROS-induced invasion and migration of pancreatic cancer cells via suppression of the ERK and p38 MAPK signaling pathways.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Movement; Diabetes Complications; Flavonoids; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Glucose; Humans; Hyperglycemia; Imidazoles; MAP Kinase Signaling System; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Pyridines; Reactive Oxygen Species; Resveratrol; Stilbenes | 2016 |
Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cinnamates; Cyclin E; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; G1 Phase; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinase 5; Membrane Potential, Mitochondrial; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Resting Phase, Cell Cycle; Saponins; Thiourea; Triterpenes | 2016 |
Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Glycoproteins; Imidazoles; Interferon-gamma; Membrane Glycoproteins; Mice; Microglia; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phenanthrolines; Potassium Channels, Inwardly Rectifying; Pyridines; Reactive Oxygen Species; Signal Transduction | 2016 |
Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death.
Topics: Acetylcysteine; Adenine; Animals; Anthracenes; Atrial Natriuretic Factor; Autophagy; Cell Line, Tumor; Cell Proliferation; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Neoplasm Staging; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Receptors, Atrial Natriuretic Factor; RNA, Small Interfering; Stomach Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Angiotensin-(1-7) protects cardiomyocytes against high glucose-induced injuries through inhibiting reactive oxygen species-activated leptin-p38 mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1/2 pathways, but not the leptin
Topics: Acetylcysteine; Angiotensin I; Animals; Anthracenes; Apoptosis; Cell Line; Glucose; Imidazoles; Leptin; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Peptide Fragments; Pyridines; Rats; Reactive Oxygen Species | 2017 |
Advanced oxidation protein products induce apoptosis, and upregulate sclerostin and RANKL expression, in osteocytic MLO-Y4 cells via JNK/p38 MAPK activation.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Advanced Oxidation Protein Products; Animals; Anthracenes; Apoptosis; Cell Line; Glycoproteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; Reactive Oxygen Species; Signal Transduction; Up-Regulation | 2017 |
Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Epithelial Cells; Free Radical Scavengers; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Thymol; Urothelium | 2017 |
Triggering of Suicidal Erythrocyte Death by Exemestane.
Topics: Acetylcysteine; Androstadienes; Aniline Compounds; Calcium; Cell Size; Cells, Cultured; Ceramides; Eryptosis; Erythrocytes; Flow Cytometry; Humans; Imidazoles; Immunoassay; Oxidative Stress; Phosphatidylserines; Pyridines; Reactive Oxygen Species; Xanthenes | 2017 |
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Erythropoietin; Gene Expression Regulation; Humans; Imidazoles; Interferon-gamma; Kidney; Kidney Transplantation; Lentivirus; MAP Kinase Kinase 4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Rats; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; STAT6 Transcription Factor | 2018 |
Protocatechuic acid inhibits Toll-like receptor-4-dependent activation of NF-κB by suppressing activation of the Akt, mTOR, JNK and p38-MAPK.
Topics: Acetylcysteine; Anthracenes; Anti-Inflammatory Agents; Cell Line, Transformed; Cytokines; Humans; Hydroxybenzoates; Imidazoles; Keratinocytes; Lipopolysaccharides; MAP Kinase Kinase 4; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Sulfones; TOR Serine-Threonine Kinases | 2018 |
P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Hypothyroidism; Imidazoles; Iodide Peroxidase; Liver; Male; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Thyrotropin-Releasing Hormone; RNA Interference; Signal Transduction; Thyroid Gland; Thyroid Hormones; Thyroxine; Triclosan; Triiodothyronine; Up-Regulation | 2018 |
The natural phenolic peperobtusin A induces apoptosis of lymphoma U937 cells via the Caspase dependent and p38 MAPK signaling pathways.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Chromans; Humans; Imidazoles; Lymphoma; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; U937 Cells | 2018 |
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.
Topics: Acetylcysteine; Animals; Antibodies; Cells, Cultured; Clodronic Acid; Coculture Techniques; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Imidazoles; Macrophages; Male; Membrane Proteins; Mice; Minocycline; Neurons; p300-CBP Transcription Factors; Paclitaxel; Peripheral Nervous System Diseases; Phosphoproteins; Phosphorylation; Proline; Pyridines; Pyruvates; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Recombinant Proteins; Sciatic Nerve; Thiocarbamates; Thrombomodulin; Up-Regulation | 2018 |
Naringenin Exerts Cardiovascular Protective Effect in a Palmitate-Induced Human Umbilical Vein Endothelial Cell Injury Model via Autophagy Flux Improvement.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Autophagy; Cardiotonic Agents; Chloroquine; Endothelium, Vascular; Flavanones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Palmitates; Pyridines; Reactive Oxygen Species | 2019 |
Methylglyoxal augments uridine diphosphate-induced contraction via activation of p38 mitogen-activated protein kinase in rat carotid artery.
Topics: Acetylcysteine; Animals; Carotid Arteries; Free Radical Scavengers; Imidazoles; Male; Muscle Contraction; Muscle, Skeletal; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Pyruvaldehyde; Rats, Wistar; Serotonin; Uridine Diphosphate | 2021 |