acetylcysteine and s-1,2-dichlorovinyl-n-acetylcysteine

acetylcysteine has been researched along with s-1,2-dichlorovinyl-n-acetylcysteine in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19904 (23.53)18.7374
1990's5 (29.41)18.2507
2000's2 (11.76)29.6817
2010's4 (23.53)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Boogaard, PJ; Commandeur, JN; Mulder, GJ; Vermeulen, NP1
Dekant, W; Henschler, D; Koob, M1
Stevens, JL; Zhang, GH1
Anders, MW; Dekant, W; Elfarra, AA; Henschler, D; Vamvakas, S1
Berthold, K; Dekant, W; Henschler, D; Schmidt, S; Vamvakas, S; Wild, D1
Dekant, W; Henschler, D; Metzler, M1
Dantzler, WH; Evans, KK; Wright, SH1
Birner, G; Dekant, W; Henschler, D; Vamvakas, S1
Dekant, W; Rosner, E1
Chilakapati, J; Korrapati, MC; Latendresse, JR; Lock, EA; Mehendale, HM; Warbritton, A1
Dnyanmote, AV; Latendresse, JR; Lock, EA; Mehendale, HM; Sawant, SP; Warbritton, AA1
Abuladze, N; Avliyakulov, NK; Bondar, G; Dekant, W; Faull, K; Koag, MC; Kurtz, I; Newman, D; Pushkin, A; Scholz, K; Tsirulnikov, K; Zhu, Q1
Elfarra, AA; Irving, RM1
Elfarra, AA; Irving, RM; Pinkerton, ME1
Chiu, W; Furuya, S; Luo, YS; Rusyn, I1
Cao, S; Han, B; Ling, X; Wang, H; Xu, J; Zhang, B; Zhang, X; Zhong, H; Zhong, R1
Bartos, P; Bartunkova, J; Chovanec, J; Cibula, D; Fucikova, J; Hraska, M; Hrnciarova, T; Kieszko, D; Klat, J; Knapp, P; Korolkiewicz, RP; Mallmann, P; Melichar, B; Minar, L; Novotny, Z; Pluta, M; Rob, L; Spacek, J; Spisek, R; Valha, P1

Reviews

1 review(s) available for acetylcysteine and s-1,2-dichlorovinyl-n-acetylcysteine

ArticleYear
Role of reactive metabolites in the circulation in extrahepatic toxicity.
    Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:9

    Topics: Acetylcysteine; Cysteine; Humans; Kidney; Liver; Trichloroethylene

2012

Trials

2 trial(s) available for acetylcysteine and s-1,2-dichlorovinyl-n-acetylcysteine

ArticleYear
Safety and efficacy of dendritic cell-based immunotherapy (DCVAC/LuCa) combined with carboplatin/pemetrexed for patients with advanced non-squamous non-small-cell lung cancer without oncogenic drivers.
    ESMO open, 2022, Volume: 7, Issue:1

    Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Dendritic Cells; Humans; Immunotherapy; Lung Neoplasms; Pemetrexed; Prospective Studies

2022
Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial.
    Journal for immunotherapy of cancer, 2022, Volume: 10, Issue:1

    Topics: Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Ovarian Epithelial; Dendritic Cells; Female; Humans; Immunotherapy; Mice; Middle Aged; Paclitaxel; Young Adult

2022

Other Studies

14 other study(ies) available for acetylcysteine and s-1,2-dichlorovinyl-n-acetylcysteine

ArticleYear
Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene.
    Archives of toxicology, 1991, Volume: 65, Issue:5

    Topics: Acetylcysteine; Animals; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Male; Mutagenicity Tests; Mutagens; Rats; Rats, Inbred Strains; Salmonella typhimurium; Stereoisomerism; Trichloroethylene

1991
Metabolism of trichloroethene--in vivo and in vitro evidence for activation by glutathione conjugation.
    Chemico-biological interactions, 1990, Volume: 73, Issue:1

    Topics: Acetylcysteine; Animals; Bile; Biotransformation; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glutathione; Homocysteine; Male; Microsomes, Liver; Molecular Structure; Rats; Rats, Inbred Strains; Trichloroethylene

1990
Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules.
    Toxicology and applied pharmacology, 1989, Volume: 100, Issue:1

    Topics: Acetylcysteine; Animals; Biological Transport; Biotransformation; Cysteine; Drug Interactions; In Vitro Techniques; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes

1989
Mutagenicity of amino acid and glutathione S-conjugates in the Ames test.
    Mutation research, 1988, Volume: 206, Issue:1

    Topics: Acetylcysteine; Animals; Carbon-Sulfur Lyases; Cysteine; gamma-Glutamyltransferase; Glutathione; Homocysteine; Kidney; Liver; Lyases; Rats; Salmonella typhimurium; Structure-Activity Relationship

1988
Enzymatic transformation of mercapturic acids derived from halogenated alkenes to reactive and mutagenic intermediates.
    Biochemical pharmacology, 1987, Sep-01, Volume: 36, Issue:17

    Topics: Acetylation; Acetylcysteine; Alkenes; Animals; Bacterial Proteins; Biotransformation; Butadienes; Carbon-Sulfur Lyases; Cytosol; Kidney; Liver; Lyases; Male; Mutagenicity Tests; Rats; Salmonella typhimurium; Subcellular Fractions

1987
Identification of S-1,2-dichlorovinyl-N-acetyl-cysteine as a urinary metabolite of trichloroethylene: a possible explanation for its nephrocarcinogenicity in male rats.
    Biochemical pharmacology, 1986, Aug-01, Volume: 35, Issue:15

    Topics: Acetylcysteine; Animals; Biotransformation; Kidney Neoplasms; Male; Rats; Rats, Inbred Strains; Trichloroethylene

1986
Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:2

    Topics: Acetylcysteine; Animals; Anion Transport Proteins; Carrier Proteins; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Mercuric Chloride; p-Aminohippuric Acid; Probenecid; Rabbits

1995
Nephrotoxic and genotoxic N-acetyl-S-dichlorovinyl-L-cysteine is a urinary metabolite after occupational 1,1,2-trichloroethene exposure in humans: implications for the risk of trichloroethene exposure.
    Environmental health perspectives, 1993, Volume: 99

    Topics: Acetylcysteine; Animals; Female; Humans; In Vitro Techniques; Kidney; Male; Mice; Mutagens; Occupational Exposure; Rats; Rats, Wistar; Risk Factors; Trichloroethylene

1993
Stereoselective formation of glutathione S-conjugates from halovinylmercapturate sulphoxides.
    Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:4

    Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Glutathione; Humans; Kidney; Kinetics; Liver; Male; Rats; Rats, Inbred F344; Sulfoxides; Time Factors

1999
Preplaced cell division: a critical mechanism of autoprotection against S-1,2-dichlorovinyl-L-cysteine-induced acute renal failure and death in mice.
    American journal of physiology. Renal physiology, 2006, Volume: 291, Issue:2

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antimitotic Agents; Blood Urea Nitrogen; Cell Division; Colchicine; Creatinine; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; G1 Phase; Kidney; Male; Mice; Phosphoprotein Phosphatases; Protein Phosphatase 1; S Phase; Signal Transduction; Time Factors

2006
Calpastatin overexpression prevents progression of S-1,2-dichlorovinyl-l-cysteine (DCVC)-initiated acute renal injury and renal failure (ARF) in diabetes.
    Toxicology and applied pharmacology, 2006, Sep-01, Volume: 215, Issue:2

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antimitotic Agents; Calcium-Binding Proteins; Calpain; Colchicine; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Kidney Function Tests; Kidney Tubules, Proximal; Longevity; Male; Mice; Regeneration

2006
Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2).
    Toxicology and applied pharmacology, 2010, Apr-15, Volume: 244, Issue:2

    Topics: Acetylcysteine; Animals; Biological Transport; Cells, Cultured; Kidney Tubules, Proximal; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Rabbits; RNA, Messenger; Transport Vesicles; Trichloroethylene; Vesicle-Associated Membrane Protein 2

2010
Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene.
    Toxicology and applied pharmacology, 2013, Feb-15, Volume: 267, Issue:1

    Topics: Acetylcysteine; Animals; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Trichloroethylene

2013
Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse.
    Journal of toxicology and environmental health. Part A, 2018, Volume: 81, Issue:1-3

    Topics: Acetylcysteine; Animals; Cysteine; Glutathione; Liver; Male; Mice; Mice, Inbred Strains; Signal-To-Noise Ratio; Tissue Distribution; Trichloroethylene

2018