acetylcysteine has been researched along with rotenone in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 24 (55.81) | 29.6817 |
| 2010's | 17 (39.53) | 24.3611 |
| 2020's | 2 (4.65) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chandel, NS; Schumacker, PT; Thompson, CB; Vander Heiden, MG | 1 |
| Felts, N; Floyd, RA; Hensley, K; Pye, QN; Salsman, S | 1 |
| Aksenov, ND; Gamaleĭ, IA; Kirpichnikova, KM; Polozov, IuS; Pospelova, TV; Tararova, ND | 1 |
| Baroni, SS; Dusi, S; Gabrielli, A; Luchetti, M; Orlandini, G; Paroncini, P; Sambo, P | 1 |
| Lehmensiek, V; Schwarz, J; Storch, A; Tan, EM | 1 |
| Benedi, J; Molina-Jimenez, MF; Sanchez-Reus, MI | 1 |
| Champy, P; Darios, F; Gleye, C; Hirsch, EC; Hocquemiller, R; Höglinger, GU; Jousset, A; Lannuzel, A; Laurens, A; Lombès, A; Medja, F; Michel, PP; Ruberg, M | 1 |
| Akaike, A; Ibi, M; Inden, M; Izumi, Y; Kihara, T; Kitamura, Y; Kohno, R; Nakamizo, T; Nakanishi, M; Sakka, N; Sawada, H; Shibasaki, H; Shimohama, S; Taniguchi, T; Yamakawa, K; Yamamoto, N | 1 |
| Andres, D; Benedi, J; Cascales, M; Molina-Jiménez, MF; Sánchez-Reus, MI | 2 |
| Bailey, SR; Flavahan, NA; Flavahan, S; Mitra, S | 1 |
| Briggs, JP; Hoidal, JR; Honeggar, M; Kohan, DE; Mizel, D; Sanders, K; Schnermann, JB; Yang, T; Zhang, A | 1 |
| Evangelinos, N; Kaloyianni, M; Koliakos, G; Koutsogiannaki, S | 1 |
| Buttigieg, J; Nurse, CA; Thompson, RJ; Zhang, M | 1 |
| Nakaki, T; Watabe, M | 1 |
| Jin, S; Johnson, LR; Ray, RM | 1 |
| Duan, S; Ge, J; He, Y; Jiang, RZ; Leung, KW; Peng, Z; Tombran-Tink, J; Zhang, YH; Zhong, XF | 1 |
| Bonham, CC; Davisson, VJ; Hindupur, J; Liu, F; Nguyen, JL; Rochet, JC; Ruf, KJ; Schieler, JL; Wood, KV; Zhu, J | 1 |
| Chang, LS; Chen, KC; Lin, SR | 1 |
| Hazra, B; Kumar, A; Kumar, B; Mishra, KP; Pandey, BN | 1 |
| Das, D; Fox, PL; Mukhopadhyay, C; Mukhopadhyay, CK; Tapryal, N | 1 |
| Antonopoulou, E; Papaefthimiou, C; Theophilidis, G | 1 |
| Jackson, T; Jengelley, TA; Jnobaptiste, R; McNaught, KS | 1 |
| Corkey, BE; Corkey, RF; Deeney, JT; Guo, W; Hu, L; Schultz, V; Shirihai, OS; Si, H; Si, Y; Wang, T | 1 |
| Hsieh, CC; Papaconstantinou, J | 1 |
| Ascoli, M; Tai, P | 1 |
| Dubé, A; Harrisson, JF; Saint-Gelais, G; Séguin, C | 1 |
| Jantas, D; Konieczny, J; Kuśmierczyk, J; Lasoń, W; Lenda, T; Lorenc-Koci, E; Roman, A | 1 |
| Aggarwal, K; Agrawal, A; Ahmad, T; Ghosh, B; Kumar, M; Mabalirajan, U; Micheal, A; Mukherjee, S; Pattnaik, B; Sethi, T; Sinha Roy, S; Tiwari, BK | 1 |
| Buck, LT; Dukoff, DJ; Hawrysh, PJ; Hogg, DW | 1 |
| Hassanzadeh, K; Izadpanah, E; Khosrobakhsh, F; Moloudi, MR; Rahimmi, A | 1 |
| Albers, DS; Alkholifi, FK | 1 |
| Beart, PM; Cater, MA; Cheung, NS; La Fontaine, S; Llanos, RM; Yap, YW | 1 |
| Durante, W; Durante, ZE; Liu, XM; Peyton, KJ | 1 |
| Bazzan, AJ; Bowen, B; Cai, J; Iacovitti, L; Intenzo, CM; Kremens, D; Liang, TW; Monti, DA; Newberg, AB; Wei, X; Wintering, NA; Zabrecky, G; Zhong, L | 1 |
| Durante, W; Liu, XM; Peyton, KJ | 1 |
| Blokland, KEC; Burgess, JK; Grainge, C; Hogaboam, CM; Jaffar, J; Khalil, N; Knight, DA; Mutsaers, SE; Pechkovsky, DV; Prêle, CM; Read, J; Reid, AT; Schuliga, M; Waters, DW; Westall, G | 1 |
| Li, D; Li, Z; Shi, L; Tian, X; Zhang, C; Zhang, J | 1 |
| Andreazza, AC; Kwak, HA; Kwok, WT | 1 |
| Fay-Karmon, T; Gutman-Sharabi, N; Halperin, R; Khashab, R; Landau, R; Leibowitz, A; Shabtai, Z; Sharabi, Y | 1 |
1 review(s) available for acetylcysteine and rotenone
| Article | Year |
|---|---|
Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway.
Topics: Acetylcysteine; Animals; Autophagy; Calcium Signaling; Humans; Lysosomes; Microarray Analysis; Neurodegenerative Diseases; Neurons; Oxidative Stress; Pesticides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, N-Methyl-D-Aspartate; Rotenone; Ubiquitin | 2016 |
1 trial(s) available for acetylcysteine and rotenone
| Article | Year |
|---|---|
N-Acetyl Cysteine May Support Dopamine Neurons in Parkinson's Disease: Preliminary Clinical and Cell Line Data.
Topics: Acetylcysteine; Aged; Antioxidants; Caudate Nucleus; Cell Differentiation; Cell Survival; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Female; Human Embryonic Stem Cells; Humans; Male; Mesencephalon; Middle Aged; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Pilot Projects; Putamen; Rotenone; Single Photon Emission Computed Tomography Computed Tomography; Tissue Culture Techniques | 2016 |
41 other study(ies) available for acetylcysteine and rotenone
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Redox regulation of p53 during hypoxia.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcysteine; Animals; Antioxidants; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Death; Cell Division; Cell Hypoxia; Cells, Cultured; Chick Embryo; Cobalt; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Ditiocarb; Fibroblasts; Fluoresceins; Humans; Hydrogen Peroxide; Mice; Mitochondria; Myocardium; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uncoupling Agents | 2000 |
Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN.
Topics: Acetylcysteine; Androstadienes; Animals; Antimycin A; Astrocytes; Blotting, Western; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Hydrogen Peroxide; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rotenone; Signal Transduction; Tumor Suppressor Proteins; Uncoupling Agents; Wortmannin | 2001 |
[Distribution of rat embryonal fibroblasts through cell cycle phases in the presence of inhibitors of active oxygen species formation and N-acetylcysteine].
Topics: 3T3 Cells; Acetylcysteine; Animals; Cell Cycle; Cells, Cultured; Culture Media; Embryo, Mammalian; Flow Cytometry; Mice; Onium Compounds; Rats; Reactive Oxygen Species; Receptors, Growth Factor; Rotenone; Signal Transduction | 2001 |
Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway.
Topics: Acetylcysteine; Allopurinol; alpha-Tocopherol; Biphenyl Compounds; Cell Division; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Fibroblasts; Growth Substances; Humans; Hydrogen Peroxide; Microscopy, Confocal; NADPH Oxidases; Onium Compounds; Oxidative Stress; Phenotype; Phosphoproteins; Protein Transport; Reactive Oxygen Species; Rotenone; Scleroderma, Localized; Scleroderma, Systemic; Skin; Up-Regulation | 2001 |
Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; alpha-Synuclein; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Herbicides; Humans; In Vitro Techniques; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Multienzyme Complexes; Mutagenesis; Nerve Tissue Proteins; Proteasome Endopeptidase Complex; Rotenone; Synucleins; Transfection; Uncoupling Agents | 2002 |
Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Coumarins; Flavonoids; Humans; L-Lactate Dehydrogenase; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rotenone | 2003 |
The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Adenosine Triphosphate; Animals; Antioxidants; Benzodiazepines; Cell Survival; Cells, Cultured; Chromans; Deoxyglucose; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Energy Metabolism; Excitatory Amino Acid Antagonists; Female; Furans; Glucose; Herbicides; Hexoses; Insecticides; Intracellular Space; Lactones; Male; Mannose; Mesencephalon; Microtubule-Associated Proteins; Mitochondria; Neurons; Neurotoxins; Plant Extracts; Pregnancy; Rats; Rats, Wistar; Reactive Oxygen Species; Rotenone; Tritium; Tyrosine 3-Monooxygenase | 2003 |
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; alpha-Synuclein; Animals; Brain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Herbicides; Immunoblotting; Immunohistochemistry; Ions; L-Lactate Dehydrogenase; Leupeptins; Male; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Phosphorylation; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Rotenone; Synucleins; Time Factors; Ubiquitin | 2004 |
Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.
Topics: Acetylcysteine; Analysis of Variance; Apoptosis; Blotting, Southern; Cell Line, Tumor; Cell Survival; Coumarins; DNA; Dose-Response Relationship, Drug; Ethidium; Flavonoids; Fluoresceins; Glutathione; Humans; Lipid Peroxidation; Microscopy, Confocal; Neuroblastoma; Neuroprotective Agents; Reactive Oxygen Species; Rotenone; Time Factors | 2004 |
Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries.
Topics: Acetylcysteine; Animals; Antioxidants; Arteries; Biological Transport; Cell Line; Cells, Cultured; Cold Temperature; Electron Transport Complex I; Humans; In Vitro Techniques; Mice; Mitochondria, Muscle; Muscle, Smooth; Myocytes, Smooth Muscle; Protein Isoforms; Reactive Oxygen Species; Receptors, Adrenergic, alpha-2; rhoA GTP-Binding Protein; Rotenone; Skin; Vasoconstriction | 2005 |
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.
Topics: Acetylcysteine; Antioxidants; Blotting, Northern; Blotting, Western; Catalase; Coumarins; Cytosol; Dose-Response Relationship, Drug; Flavonoids; Flow Cytometry; Fluorescence; Glutathione Peroxidase; Glutathione Reductase; HSP70 Heat-Shock Proteins; Humans; Immunoblotting; Luminescent Measurements; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Superoxide Dismutase; Tumor Cells, Cultured | 2005 |
Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin.
Topics: Acetylcysteine; Animals; Antioxidants; Blotting, Western; Cells, Cultured; Cyclic N-Oxides; Cyclooxygenase 2; Cytochromes c; Dinoprostone; Fluoresceins; Genes, Dominant; Hydrazones; Kidney; Kidney Tubules, Collecting; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidase 2; NADPH Oxidases; Onium Compounds; Osmosis; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Reactive Oxygen Species; Rotenone; Thenoyltrifluoroacetone; Time Factors; Xanthine; Xanthine Oxidase | 2005 |
Cytotoxic mechanisms of Zn2+ and Cd2+ involve Na+/H+ exchanger (NHE) activation by ROS.
Topics: Acetylcysteine; Amiloride; Animals; Antimycin A; Antioxidants; Cadmium; Cadmium Poisoning; Cell Survival; Gills; Hydrogen-Ion Concentration; Mytilus; Naphthalenes; Oxidants; PPAR gamma; Protein Kinase Inhibitors; Pyruvic Acid; Reactive Oxygen Species; Receptors, Adrenergic; Rosiglitazone; Rotenone; Sodium-Hydrogen Exchangers; Thiazolidinediones; Water Pollutants, Chemical; Zinc | 2006 |
A rotenone-sensitive site and H2O2 are key components of hypoxia-sensing in neonatal rat adrenomedullary chromaffin cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Adrenal Medulla; Age Factors; Animals; Animals, Newborn; Antioxidants; Cell Hypoxia; Cells, Cultured; Chromaffin Cells; Electric Stimulation; Hydrogen Peroxide; Luminescent Measurements; Membrane Potentials; Oxidants; Patch-Clamp Techniques; Potassium; Rats; Reactive Oxygen Species; Rotenone | 2007 |
Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells.
Topics: Acetylcysteine; Apoptosis; Cell Line; Cytosol; Dopamine; Dose-Response Relationship, Drug; Electron Transport Complex I; Humans; Piperazines; Reactive Oxygen Species; Rotenone; Synaptic Vesicles; Vesicular Monoamine Transport Proteins | 2007 |
TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species.
Topics: Acetylcysteine; Aminoquinolines; Animals; Antioxidants; Apoptosis; Caspase 3; Cell Line; Cycloheximide; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Hydrogen Peroxide; Intestinal Mucosa; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; NADPH Oxidases; Onium Compounds; Oxidants; Oxidative Stress; Pyrimidines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Rotenone; Signal Transduction; Tumor Necrosis Factor-alpha; Uncoupling Agents | 2008 |
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
Topics: Acetylcysteine; Adenosine Triphosphate; Adolescent; Adult; Annexin A5; Antioxidants; Apoptosis; Cells, Cultured; Cyclosporine; Cytochromes c; Electron Transport Complex I; Glaucoma, Open-Angle; Humans; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Middle Aged; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Reactive Oxygen Species; Rotenone; Trabecular Meshwork; Uncoupling Agents; Vitamin E | 2008 |
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Antioxidants; Blotting, Western; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Mesencephalon; Methionine Sulfoxide Reductases; Mice; Neurons; Oxidation-Reduction; Oxidoreductases; Parkinson Disease; Rats; Rotenone; Uncoupling Agents; Vitamin E | 2008 |
Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.
Topics: Acetylcysteine; Apoptosis; Caspases; Cell Line, Tumor; Cobra Cardiotoxin Proteins; Cyclosporine; Cytochromes c; Elapid Venoms; Enzyme Activation; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Uncoupling Agents | 2008 |
Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells.
Topics: Acetylcysteine; Allopurinol; Animals; Antimycin A; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cardiolipins; Cell Line, Tumor; Cyclosporine; Cytochromes c; Female; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rotenone; Uncoupling Agents; Vitamin K 3 | 2009 |
Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases.
Topics: 3' Untranslated Regions; Acetylcysteine; Animals; Antifungal Agents; Antimycin A; Cell Line, Tumor; Ceruloplasmin; Free Radical Scavengers; Humans; Hydrogen Peroxide; Iron Overload; Mice; Mice, Knockout; Neurodegenerative Diseases; Organ Specificity; Oxidants; Oxidation-Reduction; Oxidative Stress; RNA Stability; RNA-Binding Proteins; Rotenone; Uncoupling Agents | 2009 |
Inhibitory vs. protective effects of N-acetyl-l-cysteine (NAC) on the electromechanical properties of the spontaneously beating atria of the frog (Rana ridibunda): an ex vivo study.
Topics: Acetylcysteine; Action Potentials; Animals; Atrial Function; Cadmium; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Female; Free Radical Scavengers; Heart Atria; In Vitro Techniques; Male; Myocytes, Cardiac; No-Observed-Adverse-Effect Level; Rana ridibunda; Rotenone | 2009 |
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.
Topics: Acetylcysteine; Animals; Blotting, Western; Canavanine; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Immunohistochemistry; Locus Coeruleus; Male; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Folding; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Uncoupling Agents | 2010 |
Respiration in adipocytes is inhibited by reactive oxygen species.
Topics: Acetylcysteine; Adenosine Diphosphate; Adenosine Triphosphate; Adipocytes; Adipose Tissue; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Respiration; Dietary Fats; Electron Transport Complex I; Free Radical Scavengers; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidative Phosphorylation; Oxidative Stress; Oxygen Consumption; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone | 2010 |
Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS).
Topics: Acetylcysteine; Activating Transcription Factor 2; Aging; Animals; Antimycin A; Cell Proliferation; Electron Transport Chain Complex Proteins; Enzyme Inhibitors; Fibroblasts; Hydrogen Peroxide; Longevity; Male; MAP Kinase Kinase Kinase 5; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Mitochondria; Nitro Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propionates; Protein Binding; Reactive Oxygen Species; Rotenone; Skin; Thioredoxins | 2009 |
Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1/2 in Leydig cells.
Topics: Acetylcysteine; Animals; Antimycin A; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Chorionic Gonadotropin; Cyclic AMP; Cyclic CMP; Enzyme Activation; Glutathione; Leydig Cells; Male; Mice; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligomycins; Phosphorylation; Progesterone; ras Proteins; Reactive Oxygen Species; Rotenone; Uncoupling Agents | 2011 |
Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1).
Topics: Acetylcysteine; Animals; Blotting, Northern; Cell Hypoxia; Chlorides; Chromosome Mapping; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Genes, Reporter; HEK293 Cells; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Luciferases; Metallothionein; Methacrylates; Mice; Mutagenesis, Site-Directed; NIH 3T3 Cells; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Stability; Rotenone; Signal Transduction; Thiazoles; Transcription Factor MTF-1; Transcription Factors; Transcriptional Activation; Transfection; Zinc Compounds | 2011 |
The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
Topics: Acetylcysteine; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Humans; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Time Factors; Tretinoin; Triterpenes | 2013 |
Computational classification of mitochondrial shapes reflects stress and redox state.
Topics: Acetylcysteine; Algorithms; Anti-Bacterial Agents; Antimycin A; Antioxidants; Calcium; Cell Line; Flow Cytometry; Humans; Mitochondria; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Rotenone | 2013 |
Scavenging ROS dramatically increase NMDA receptor whole-cell currents in painted turtle cortical neurons.
Topics: Acetylcysteine; Animals; Calcium; Cerebral Cortex; Female; Free Radical Scavengers; Hydrogen Peroxide; Membrane Potentials; Mitochondria; Neurons; Oxygen; Patch-Clamp Techniques; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Rotenone; Tiopronin; Turtles | 2014 |
N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins.
Topics: Acetylcysteine; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Drug Interactions; Dynamins; Male; Oxidative Stress; Parkinsonian Disorders; Protein Binding; Random Allocation; Rats; Rats, Wistar; Rotarod Performance Test; Rotenone; Substantia Nigra; Ubiquitin-Protein Ligases | 2015 |
Attenuation of rotenone toxicity in SY5Y cells by taurine and N-acetyl cysteine alone or in combination.
Topics: Acetylcysteine; Aconitate Hydratase; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; L-Lactate Dehydrogenase; Neuroprotective Agents; Rotenone; Taurine | 2015 |
Heme oxygenase-1-derived bilirubin counteracts HIV protease inhibitor-mediated endothelial cell dysfunction.
Topics: Acetylcysteine; Atazanavir Sulfate; Bilirubin; Cardiovascular Diseases; Cell Proliferation; Endothelial Cells; Gene Expression Regulation; Heme Oxygenase-1; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; NF-E2-Related Factor 2; Promoter Regions, Genetic; Reactive Oxygen Species; Ritonavir; Rotenone | 2016 |
Ammonia promotes endothelial cell survival via the heme oxygenase-1-mediated release of carbon monoxide.
Topics: Acetylcysteine; Ammonia; Ammonium Chloride; Animals; Arteries; Carbon Monoxide; Cell Survival; Endothelial Cells; Gene Expression Regulation; Heme Oxygenase-1; Humans; Mice; NF-E2-Related Factor 2; Promoter Regions, Genetic; Reactive Oxygen Species; Rotenone; Signal Transduction; Tumor Necrosis Factor-alpha | 2017 |
Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts.
Topics: Acetylcysteine; Biomarkers; Cellular Senescence; Cyclic N-Oxides; Down-Regulation; Etoposide; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Lung; Mitochondria; Myofibroblasts; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rotenone; Sirolimus | 2018 |
Near-infrared fluorescence probe for hydrogen peroxide detection: design, synthesis, and application in living systems.
Topics: Acetylcysteine; Animals; Antioxidants; Boronic Acids; Fluorescence; Fluorescent Dyes; Hep G2 Cells; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Indoles; Limit of Detection; Mice, Inbred BALB C; Microscopy, Confocal; Microscopy, Fluorescence; Oxidation-Reduction; Rotenone; Temperature | 2019 |
N-acetylcysteine modulates rotenone-induced mitochondrial Complex I dysfunction in THP-1 cells.
Topics: Acetylcysteine; DNA, Mitochondrial; Electron Transport Complex I; Humans; Oxidative Stress; Reactive Oxygen Species; Rotenone; Superoxides; THP-1 Cells | 2023 |
Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson's Disease.
Topics: Acetylcysteine; Aldehyde Dehydrogenase; Animals; Dopamine; Monoamine Oxidase Inhibitors; Parkinson Disease; Rats; Rotenone; Selegiline | 2023 |