acetylcysteine has been researched along with pyrazolanthrone in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (23.33) | 29.6817 |
| 2010's | 43 (71.67) | 24.3611 |
| 2020's | 3 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H | 1 |
| Jhon, DY; Kim, YS; Lee, KY | 1 |
| Lee, YJ; Shukla, SD | 1 |
| Allshire, A; Anoopkumar-Dukie, S; Carey, JB; Conere, T | 1 |
| Han, ST; Kim, YH; Kwon, TK; Park, EJ; Park, JW | 1 |
| Cheng, YW; Kang, JJ; Lee, CC | 1 |
| Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
| Huang, W; Li, L; Min, T; Xu, J | 1 |
| Chen, YC; Lin, CW; Shen, SC; Yang, LY | 1 |
| Du, W; Li, P; Miao, YX; Wang, CB; Xing, YX | 1 |
| Daskal, I; Kwok, SC | 1 |
| Ai, L; Beebe, T; Cui, J; Hsiai, T; Khalsa, B; Li, R; Majumdar, R; Ning, Z; Sioutas, C; Takabe, W | 1 |
| Higaki, J; Higashiyama, S; Inoue, H; Nakayama, H; Okayama, H; Okura, T; Uetani, T | 1 |
| Chang, WY; Choi, YH; Hyun, JW; Kim, GY; Kim, MO; Moon, DO | 1 |
| Chang, JW; Han, NJ; Kim, YJ; Lee, JM; Park, SK; Yang, WS | 1 |
| Cheng, ML; Cheng, TH; Chiu, DT; Ho, HY; Lin, CJ; You, TH; Yu, JS | 1 |
| Fang, F; Fu, YQ; Kuang, FW; Lu, ZY; Xu, F | 1 |
| Cho, DH; Hur, DY; Kim, YS; Lee, HK; Lee, WJ; Park, GB; Song, H | 1 |
| Agrawal, M; Bala Bhaskar, AS; Gupta, N; Lakshmana Rao, PV; Ravindran, J | 1 |
| Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C | 1 |
| Hu, Y; Shi, Y; Song, Y; Wang, Y; Yang, K; Yu, H | 1 |
| Chen, YC; Cheng, MC; Chien, CC; Huang, GC; Lin, CT; Shen, SC; Wu, J; Yang, LY | 1 |
| Fukaya, M; Kaneki, M; Kim, M; Kitamura, T; Mao, J; Shimizu, N; Shinozaki, S; Tamura, Y; Tanioka, T | 1 |
| Balazs, L; Bezawada, L; Ghosh, MC; Gorantla, VK; Luellen, C; Makena, PS; Parthasarathi, K; Sinclair, SE; Waters, CM | 1 |
| Chen, CH; Chou, MH; Chuang, JH; Hsiao, CC; Lee, JJ; Wei, YC; Wu, CL; Yang, IH | 1 |
| Ehrlich, M; Pinkas-Kramarski, R; Schmukler, E; Shai, B | 1 |
| Hwangbo, C; Kim, N; Lee, JH; Lee, S | 1 |
| Chenyang, J; Jiajing, W; Jianchun, B; Jianhong, G; Xuezhong, L; Yan, Y; Yiran, Z; Zongping, L | 1 |
| Han, HJ; Jeon, JH; Oh, KB; Park, JK; Park, SS; Ryu, JM; Seo, BN; Yun, SP | 1 |
| Damdindorj, L; Hosokawa, Y; Hossain, E; Karnan, S; Konishi, H; Konishi, Y; Ota, A; Takahashi, M | 1 |
| Jeong, SJ; Jung, JH; Kim, B; Kim, JH; Kim, SH; Lee, HJ; Sohn, EJ; Sook, SH | 1 |
| Phelan, S; Taparra, K; Tehan, L | 1 |
| Kim, SJ; Yu, SM | 1 |
| Chen, J; Guo, R; Huang, R; Li, S; Tian, L; Wu, K; Yan, H; You, Q | 1 |
| Jeng, CJ; Liao, CK; Wang, HS; Wang, SH; Wu, JC | 1 |
| Abe, N; Aritomi, K; Irie, T; Irikura, M; Ishitsuka, Y; Kai, H; Shimizu, D; Shuto, T; Tomishima, Y | 1 |
| Chauvin, MA; Croze, ML; Géloën, A; Guichardant, M; Koppe, L; Pesenti, S; Pillon, NJ; Rieusset, J; Soulage, CO; Vella, RE; Zarrouki, B | 1 |
| Castoldi, M; Häussinger, D; Paluschinski, M; Santosa, D; Sommerfeld, A | 1 |
| Barzegar, M; Chen, X; Gu, Y; Huang, S; Jiang, S; Mahdavian, E; Salvatore, BA; Shang, C; Wu, Y | 1 |
| Deng, YT; Hsieh, YP; Ko, HH; Kuo, MY; Wu, KJ; Yeh, CC | 1 |
| Du, X; Huang, Q; Li, K; Ou, Y; Tao, Y; Tu, P; Yin, H | 1 |
| Gao, HW; He, YY; Khan, M; Li, YM; Ma, TH; Yang, JB; Yao, M | 1 |
| Li, BW; Li, Z; Tang, J; Tao, JQ; Wang, JW; Wang, LJ; Wang, WZ; Wei, S; Xie, KL; Xu, H; Xu, ZK; Yang, L; Zhang, DC; Zhang, Q; Zhi, XF; Zhu, Y | 1 |
| Blank, V; Fink, D; Gutsche, K; Leo, C; Randi, EB; Scholz, CC; Wenger, RH | 1 |
| Chen, J; Cheng, F; Feng, J; Lan, J; Lei, Y; Mei, W; Xu, Q; Zeng, B; Zhai, Y; Zhang, W; Zhen, Y; Zheng, D | 1 |
| Guo, M; Shao, J; Zhang, Z; Zhao, S; Zheng, S | 1 |
| Huang, D; Lin, B; Liu, S; Liu, Y; Wang, K; Wu, W; Yu, C; Zhang, H | 1 |
| Chen, JX; Ding, KF; Du, CJ; Gao, F; Hu, SM; Li, SJ; Li, Y; Mao, XW; Miyamoto, H; Wen, JM; Zhang, N; Zhang, SG | 1 |
| Chen, S; Guo, L; Guo, X; Liu, F; Mei, N; Ren, Z; Zhang, Z | 1 |
| Hong, L; Huang, Z; Li, H; Miao, B; Na, N; Zhang, J; Zhao, D | 1 |
| Bai, B; Dong, A; Jing, X; Liu, H; Wang, H | 1 |
| Lee, CS; Nam, YJ | 1 |
| Bao, YQ; Gu, LL; Li, YL; Lu, H; Shen, ZL | 1 |
| Chen, B; Fang, D; Li, D; Luo, J; Ni, F; Xiang, Y; Xu, X; Zhou, M; Zhu, X | 1 |
| Li, X; Liu, F; Luo, J; Yang, H; Yang, Y; Zhao, Q | 1 |
| Ji, Z; Liu, Z; Xia, Z; Xu, H; Xu, R; Xu, S; Zhao, W | 1 |
| Jing, GC; Liu, D; Liu, YQ; Zhang, MR | 1 |
| Chen, A; Chen, L; Chen, S; Dai, X; He, F; Huang, C; Jiang, Y; Li, S; Li, T; Lian, J; Sun, L; Xiang, L; Xiao, H; Yan, X; Yang, M; Zhang, Y | 1 |
60 other study(ies) available for acetylcysteine and pyrazolanthrone
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins | 2003 |
Involvement of ROS and JNK1 in selenite-induced apoptosis in Chang liver cells.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Catechin; Cell Line; DNA Fragmentation; Free Radical Scavengers; Humans; Liver; Mitogen-Activated Protein Kinase 8; Phosphorylation; Reactive Oxygen Species; Selenium; Signal Transduction | 2004 |
Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes.
Topics: Acetaldehyde; Acetylcysteine; Animals; Anthracenes; Apoptosis; Blotting, Western; Butadienes; Buthionine Sulfoximine; Caspase 3; Caspases; Cell Nucleus; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ethanol; Genistein; Hepatocytes; Hydrogen Peroxide; Indoles; JNK Mitogen-Activated Protein Kinases; Male; Maleates; Maleimides; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors | 2005 |
Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines.
Topics: Acetylcysteine; Anthracenes; Antioxidants; Apoptosis; Ascorbic Acid; Butadienes; Cell Line, Tumor; Cell Proliferation; DNA Damage; Enzyme Inhibitors; Fluoresceins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Melatonin; Mitochondria; Nitriles; Nitrites; Oxazines; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Radiation Tolerance; Rhodamines; Spectrometry, Fluorescence; Xanthenes | 2005 |
Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells.
Topics: Acetylcysteine; Anthracenes; Arsenic Trioxide; Arsenicals; Blotting, Western; Cells, Cultured; DNA Primers; DNA-Binding Proteins; Gene Expression Regulation; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; Luciferases; MAP Kinase Kinase 4; Oxides; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factors | 2005 |
Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells.
Topics: Acetylcysteine; Anthracenes; Cell Line, Tumor; Cell Survival; Epithelial Cells; Flavonoids; Gene Expression Regulation; Humans; Interleukin-8; Motorcycles; NF-kappa B; Proline; RNA, Messenger; Thiocarbamates; Vehicle Emissions | 2005 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
Up-regulation of P-glycoprotein expression by catalase via JNK activation in HepG2 cells.
Topics: Acetylcysteine; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Catalase; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression; Humans; JNK Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Rhodamines; RNA, Messenger; Time Factors; Up-Regulation | 2006 |
IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Anthracenes; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Flavanones; Flavonoids; Glycosides; Humans; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Molecular Structure; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Quercetin; Reactive Oxygen Species; Signal Transduction; Structure-Activity Relationship; Transfection | 2007 |
Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri.
Topics: Acetylcysteine; Animals; Anthracenes; Antioxidants; Apoptosis; Cell Line; Desipramine; Dose-Response Relationship, Drug; Enzyme Activation; Free Radical Scavengers; Humans; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Pectinidae; Peptides; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species; Signal Transduction; Sphingomyelin Phosphodiesterase; Ultraviolet Rays | 2008 |
Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Brefeldin A; Buthionine Sulfoximine; DNA-Binding Proteins; Enzyme Inhibitors; Free Radical Scavengers; Humans; JNK Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Regulatory Factor X Transcription Factors; Response Elements; Transcription Factor CHOP; Transcription Factors; Up-Regulation; X-Box Binding Protein 1 | 2008 |
Ultrafine particles from diesel engines induce vascular oxidative stress via JNK activation.
Topics: Acetylcysteine; Anthracenes; Aorta; Cells, Cultured; Endothelial Cells; Enzyme Activation; Gasoline; Gene Expression Regulation; Heme Oxygenase-1; Humans; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Nanoparticles; Oxidative Stress; Particulate Matter; RNA, Small Interfering; Superoxides; Thromboplastin | 2009 |
Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Anthracenes; Apoptosis; Caspase 3; Cell Hypoxia; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Disintegrins; Free Radical Scavengers; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mutation; Myoblasts, Cardiac; Rats; Reactive Oxygen Species | 2009 |
Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cell Proliferation; Cell Survival; Chalcones; Dose-Response Relationship, Drug; Enzyme Activation; G2 Phase; Glutathione; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Reactive Oxygen Species | 2010 |
Mycophenolic acid attenuates tumor necrosis factor-alpha-induced endothelin-1 production in human aortic endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mycophenolic Acid; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2010 |
Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Dual Specificity Phosphatase 1; Flavonoids; Gene Knockdown Techniques; Glucosephosphate Dehydrogenase; Hep G2 Cells; Humans; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Pyridines | 2010 |
N-acetylcysteine protects alveolar epithelial cells from hydrogen peroxide-induced apoptosis through scavenging reactive oxygen species and suppressing c-Jun N-terminal kinase.
Topics: Acetylcysteine; Alveolar Epithelial Cells; Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Down-Regulation; Free Radical Scavengers; Glutathione; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Male; Oxidants; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Tumor Suppressor Protein p53 | 2010 |
Endoplasmic reticulum stress-mediated apoptosis of EBV-transformed B cells by cross-linking of CD70 is dependent upon generation of reactive oxygen species and activation of p38 MAPK and JNK pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Antibodies, Monoclonal; Apoptosis; B-Lymphocytes; Callithrix; CD27 Ligand; Cell Line, Transformed; Chelating Agents; Cinnamates; Egtazic Acid; Endoplasmic Reticulum; Epstein-Barr Virus Infections; Free Radical Scavengers; Herpesvirus 4, Human; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Thiourea; Unfolded Protein Response | 2010 |
Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase 7; Caspase 9; Cell Line, Tumor; Cyclosporins; Cytochromes c; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Reactive Oxygen Species; U937 Cells | 2011 |
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species | 2011 |
p,p'-Dichlorodiphenoxydichloroethylene induced apoptosis of Sertoli cells through oxidative stress-mediated p38 MAPK and mitochondrial pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Survival; Cytochromes c; Dichlorodiphenyl Dichloroethylene; Gene Expression; Imidazoles; Insecticides; Male; Mitochondria; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells | 2011 |
Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Chromatin; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioma; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Vitamin K 3 | 2011 |
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
Topics: Acetylcysteine; Animals; Anthracenes; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Activation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin Receptor Substrate Proteins; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2011 |
Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Line; Cytochromes c; Epithelial Cells; Hyperoxia; JNK Mitogen-Activated Protein Kinases; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidants; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Respiration, Artificial; Tidal Volume | 2011 |
High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5.
Topics: Acetylcysteine; Animals; Anthracenes; Cattle; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Glycation End Products, Advanced; Glycyrrhizic Acid; HMGB1 Protein; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Rats; Reactive Oxygen Species; Retinal Ganglion Cells; RNA, Messenger; Serum Albumin, Bovine; Signal Transduction; Vascular Endothelial Growth Factor A | 2012 |
Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition.
Topics: Acetylcysteine; Adenine; Anthracenes; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Death; Cell Line, Tumor; Humans; Male; MAP Kinase Signaling System; Membrane Proteins; Neoplasms, Hormone-Dependent; Neuregulins; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Recombinant Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Eupatolide inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through ROS-dependent heme oxygenase-1 induction.
Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Imidazoles; Inula; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Nitriles; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2013 |
Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cadmium; Cell Line; Extracellular Signal-Regulated MAP Kinases; Glutathione Peroxidase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Malondialdehyde; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2013 |
Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-κB, and Akt inhibition.
Topics: Acetylcysteine; Animals; Anthocyanins; Anthracenes; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Hypoxia; Cell Line; Embryonic Stem Cells; Gene Expression Regulation; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Mice; Mitochondria; NF-kappa B; Oxygen; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction | 2013 |
Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells.
Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Arsenites; Cardiovascular Diseases; Cell Line; Cell Proliferation; Endothelium, Vascular; Environmental Pollutants; Enzyme Inhibitors; Free Radical Scavengers; Mice; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Sodium Compounds; Up-Regulation | 2013 |
Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.
Topics: Acetyl-CoA Carboxylase; Acetylcysteine; AMP-Activated Protein Kinases; Anthracenes; Apoptosis; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclooxygenase 2; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Multiple Myeloma; Phosphorylation; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Sitosterols | 2014 |
Peroxiredoxin overexpression in MCF-7 breast cancer cells and regulation by cell proliferation and oxidative stress.
Topics: Acetylcysteine; Anthracenes; Antioxidants; Breast Neoplasms; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Oxidative Stress; Peroxiredoxins; Reactive Oxygen Species; RNA, Messenger; Up-Regulation | 2013 |
Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcysteine; Animals; Anions; Anthracenes; Apoptosis; Benzoquinones; Cartilage, Articular; Cell Proliferation; Cell Survival; Chondrocytes; Enzyme Activation; Free Radical Scavengers; Imidazoles; Intracellular Space; Ion Channels; Mitochondria; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Rabbits; Reactive Oxygen Species; Signal Transduction | 2013 |
Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Flavanones; Fruit; Glucose; Hyperglycemia; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rats; Reactive Oxygen Species | 2014 |
Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Astrocytes; Connexin 43; Down-Regulation; Gap Junctions; JNK Mitogen-Activated Protein Kinases; Leupeptins; Lipopolysaccharides; NF-kappa B; Proteasome Endopeptidase Complex; Proteolysis; Rats; Signal Transduction; Ubiquitination; Ubiquitins | 2013 |
Evaluation of three-dimensional cultured HepG2 cells in a nano culture plate system: an in vitro human model of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Anthracenes; Cells, Cultured; Cyclosporine; Cytochrome P-450 CYP2E1; Drug Evaluation, Preclinical; Glutathione; Hep G2 Cells; Humans; Liver; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Nanotechnology; Toxicity Tests | 2014 |
Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation.
Topics: Acetylcysteine; Animals; Anthracenes; Bronchoalveolar Lavage Fluid; Cell Line; Enzyme Activation; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Mice; Ozone; Phenylbutyrates; Rats | 2015 |
Hyperosmotic stress activates the expression of members of the miR-15/107 family and induces downregulation of anti-apoptotic genes in rat liver.
Topics: Acetophenones; Acetylcysteine; Animals; Anthracenes; Apoptosis; Benzylamines; Down-Regulation; Early Growth Response Protein 1; fas Receptor; Forkhead Box Protein O3; Forkhead Transcription Factors; JNK Mitogen-Activated Protein Kinases; Liver; MicroRNAs; Oligonucleotide Array Sequence Analysis; Osmolar Concentration; Osmoregulation; Osmosis; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Reproducibility of Results; RNA, Messenger; Stress, Physiological; Transcriptome; Up-Regulation | 2015 |
Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5.
Topics: Acetylcysteine; Animals; Anthracenes; Blotting, Western; Cell Death; Cell Survival; Chlorocebus aethiops; Chromones; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Free Radical Scavengers; HEK293 Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Nuclear Proteins; Phosphoprotein Phosphatases; Protein Phosphatase 2; Reactive Oxygen Species | 2015 |
Phenethyl isothiocyanate enhances TRAIL-induced apoptosis in oral cancer cells and xenografts.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Heterografts; Humans; In Situ Nick-End Labeling; Isothiocyanates; Mice; Mouth Neoplasms; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2016 |
Aloe-emodin-mediated photodynamic therapy induces autophagy and apoptosis in human osteosarcoma cell line MG‑63 through the ROS/JNK signaling pathway.
Topics: Acetylcysteine; Anthracenes; Anthraquinones; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Osteosarcoma; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species | 2016 |
Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cinnamates; Cyclin E; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; G1 Phase; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinase 5; Membrane Potential, Mitochondrial; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Resting Phase, Cell Cycle; Saponins; Thiourea; Triterpenes | 2016 |
Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death.
Topics: Acetylcysteine; Adenine; Animals; Anthracenes; Atrial Natriuretic Factor; Autophagy; Cell Line, Tumor; Cell Proliferation; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Neoplasm Staging; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Receptors, Atrial Natriuretic Factor; RNA, Small Interfering; Stomach Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells.
Topics: Acetylcysteine; Anthracenes; Cell Hypoxia; Cell Line, Tumor; Cyclooxygenase 2; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Mammary Glands, Human; Matrix Metalloproteinase 9; Neoplasm Metastasis; NF-E2-Related Factor 2; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Oxidative Stress; Oxygen; Phosphorylation; Proto-Oncogene Proteins c-jun; Signal Transduction; Sulfones; Tenascin | 2016 |
Angiotensin-(1-7) protects cardiomyocytes against high glucose-induced injuries through inhibiting reactive oxygen species-activated leptin-p38 mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1/2 pathways, but not the leptin
Topics: Acetylcysteine; Angiotensin I; Animals; Anthracenes; Apoptosis; Cell Line; Glucose; Imidazoles; Leptin; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Peptide Fragments; Pyridines; Rats; Reactive Oxygen Species | 2017 |
ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis.
Topics: Acetylcysteine; Animals; Anthracenes; Anti-Inflammatory Agents; Antioxidants; Artemisinins; Autophagy; Carbon Tetrachloride; Gene Expression Regulation; Glutathione; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Small Interfering | 2016 |
Advanced oxidation protein products induce apoptosis, and upregulate sclerostin and RANKL expression, in osteocytic MLO-Y4 cells via JNK/p38 MAPK activation.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Advanced Oxidation Protein Products; Animals; Anthracenes; Apoptosis; Cell Line; Glycoproteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; Reactive Oxygen Species; Signal Transduction; Up-Regulation | 2017 |
Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Epithelial Cells; Free Radical Scavengers; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Thymol; Urothelium | 2017 |
ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells.
Topics: Acetylcysteine; Anthracenes; Autophagy; Comet Assay; Cyclic N-Oxides; DNA Damage; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Oxidative Stress; Reactive Oxygen Species | 2018 |
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Erythropoietin; Gene Expression Regulation; Humans; Imidazoles; Interferon-gamma; Kidney; Kidney Transplantation; Lentivirus; MAP Kinase Kinase 4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Rats; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; STAT6 Transcription Factor | 2018 |
Overexpression of TIMP3 Protects Against Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Apoptosis Through ROS/Mapks Pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cells, Cultured; Cyclic N-Oxides; Doxorubicin; Echocardiography; Heart; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Spin Labels; Tissue Inhibitor of Metalloproteinase-3 | 2017 |
Protocatechuic acid inhibits Toll-like receptor-4-dependent activation of NF-κB by suppressing activation of the Akt, mTOR, JNK and p38-MAPK.
Topics: Acetylcysteine; Anthracenes; Anti-Inflammatory Agents; Cell Line, Transformed; Cytokines; Humans; Hydroxybenzoates; Imidazoles; Keratinocytes; Lipopolysaccharides; MAP Kinase Kinase 4; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Sulfones; TOR Serine-Threonine Kinases | 2018 |
Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells.
Topics: Acetylcysteine; Alkaloids; Amino Acid Chloromethyl Ketones; Anthracenes; Antioxidants; Antiviral Agents; Apoptosis; Butylamines; Cell Line; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Free Radical Scavengers; Gene Expression Regulation; Hepatocytes; Humans; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Quinolizines; Reactive Oxygen Species | 2018 |
High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Glucose; Humans; JNK Mitogen-Activated Protein Kinases; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species | 2018 |
Naringenin Exerts Cardiovascular Protective Effect in a Palmitate-Induced Human Umbilical Vein Endothelial Cell Injury Model via Autophagy Flux Improvement.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Autophagy; Cardiotonic Agents; Chloroquine; Endothelium, Vascular; Flavanones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Palmitates; Pyridines; Reactive Oxygen Species | 2019 |
Mechanistic study of mtROS-JNK-SOD2 signaling in bupivacaine-induced neuron oxidative stress.
Topics: Acetylcysteine; Animals; Anthracenes; Antioxidants; Bupivacaine; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Gene Knockdown Techniques; Humans; Injections, Spinal; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitochondria; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Rats; Reactive Oxygen Species; RNA, Small Interfering; Superoxide Dismutase; Transcriptional Activation | 2020 |
Nao-Fu-Cong ameliorates diabetic cognitive dysfunction by inhibition of JNK/CHOP/Bcl2-mediated apoptosis in vivo and in vitro.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Transcription Factor CHOP | 2020 |
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.
Topics: Acetylcysteine; Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Liver Neoplasms; Male; MAP Kinase Kinase 4; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Sorafenib; Tumor Burden; Xenograft Model Antitumor Assays | 2021 |