acetylcysteine and pyrazines

acetylcysteine has been researched along with pyrazines in 40 studies

Research

Studies (40)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (7.50)	18.2507
2000's	23 (57.50)	29.6817
2010's	14 (35.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lunn, WH; Shadle, JK	1
Bagnasco, M; Bennicelli, C; Camoirano, A; De Flora, S; Kensler, TW; Qian, GS; van Zandwijk, N; Wigbout, G; Zhu, YR	1
Egner, PA; Groopman, JD; He, X; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Muñoz, A; Qian, GS; Shen, X; Wang, JB; Wang, JS; Zarba, A; Zhang, BC; Zhu, YR	1
Adams, J; Chau, V; Elliott, PJ; Lightcap, ES; McCormack, TA; Pien, CS	1
An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB	1
Balansky, RM; Bennicelli, C; Dagostini, F; De Flora, S; Grubbs, CJ; Izzotti, A; Kelloff, GJ; Lubet, RA; Myers, SR	1
Bolanowska-Higdon, W; Creaven, PJ; Hitt, S; Lawrence, D; Murphy, M; Pendyala, L; Schwartz, G; Zdanowicz, J	1
Camoirano, A; Cartiglia, C; De Flora, S; Izzotti, A; Tampa, E	1
Elliott, PJ; Ross, JS	1
Schenkein, D	1
Pastorino, U; van Zandwijk, N	1
Boehncke, WH; Elliott, PJ; Zollner, TM	1
Luker, GD; Luker, KE; Pica, CM; Piwnica-Worms, D; Song, J	1
Dai, Y; Grant, S; Pei, XY	1
Daniel, KG; Dou, QP; Kazi, A; Kuhn, DJ	1
Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W	1
Bhat, GJ; Niture, SK; Smith, QR; Srivenugopal, KS; Velu, CS	1
Berges, C; Daniel, V; Fuchs, D; Höh, A; Miltz, M; Naujokat, C; Opelz, G; Ovens, J; Sadeghi, M; Wieczorek, H	1
Anselmino, A; Atzori, C; Cargnel, A; Mazza, F; Piccinini, M; Rinaudo, MT; Tronconi, E; Valerio, A	1
Blau, IW; Busse, A; Driessen, C; Keilholz, U; Kraus, M; Na, IK; Rietz, A; Scheibenbogen, C; Thiel, E	1
Berges, C; Daniel, V; Fuchs, D; Haberstock, H; Miltz, M; Naujokat, C; Opelz, G; Sadeghi, M	1
Caligaris-Cappio, F; Cozza, S; Ferrarini, M; Nerini-Molteni, S; Sitia, R	1
Chen, D; Dou, QP; Landis-Piwowar, KR; Milacic, V; Yang, H	1
Al-Husseini, I; Al-Salam, S; Ali, BH; Nemmar, A	1
Tsukamoto, S; Yokosawa, H	1
Böll, B; Chalaris, A; Eichenauer, DA; Engert, A; Hansen, HP; Krell, HW; Reiners, KS; Rose-John, S; Simhadri, VL; Simhadri, VR; Vahdat, AM; von Strandmann, EP; Wiegmann, K	1
Calin, GA; Cartiglia, C; Croce, CM; De Flora, S; Izzotti, A; Longobardi, M; Steele, VE	1
Alden, CL; Cardoza, K; Csizmadia, E; Csizmadia, V; Fedyk, ER; Gallacher, M; Kadambi, VJ; O'Brien, L; Raczynski, A; Silverman, L; Simpson, C	1
David, CS; Patel, R; Rajagopalan, G; Theuer, JE; Tilahun, AY	1
Bui, TN; Efuet, ET; Keyomarsi, K	1
Li, J; Wu, XM; Zhang, DY	1
Abe, M; Amou, H; Fujii, S; Harada, T; Hiasa, M; Kagawa, K; Matsumoto, T; Miki, H; Nakamura, S; Nakano, A; Oda, A; Ozaki, S; Takeuchi, K; Watanabe, T	1
Azakir, BA; Di Fulvio, S; Kinter, J; Sinnreich, M	1
Al-Husein, B; Al-Shabrawey, M; Bollag, WB; Choudhary, V; Davis, M; Dong, Z; El Gaish, M; Kaddour-Djebbar, I; Kumar, MV; Lakshmikanthan, V; Shirley, R; Zhong, R	1
Andreu, AL; Barreiro, E; de Kier Joffé, ED; Fermoselle, C; García-Arumí, E; Puente-Maestu, L; Puig-Vilanova, E; Tejedor, A; Urtreger, AJ	1
Chan, SM; Feng, W; Huang, M; Li, MX; Majeti, R; Mitchell, BS; Thomas, D	1
Bader, M; Grassner, L; Knight, AM; Loprinzi, CL; Paz, J; Podratz, JL; Staff, NP; Trushina, E; Windebank, AJ	1
Nageswara Rao, R; Padiya, R; Ramakrishna, K; Saida, S; Sravan, B	1
Han, J; Heo, HJ; Jeong, SH; Jeong, YJ; Kim, HK; Kim, N; Ko, KS; Ko, TH; Lee, SR; Rhee, BD; Song, IS; Youm, JB	1
Chai, C; Dong, B; Kang, A; Li, W; Shan, CX; Shen, F; Wen, HM; Zhang, JY; Zhang, Q	1

Reviews

8 review(s) available for acetylcysteine and pyrazines

Article	Year
The proteasome: a new target for novel drug therapies. American journal of clinical pathology, 2001, Volume: 116, Issue:5 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Carcinoma, Lewis Lung; Clinical Trials, Phase I as Topic; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Pyrazines	2001
Proteasome inhibitors in the treatment of B-cell malignancies. Clinical lymphoma, 2002, Volume: 3, Issue:1 Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Cycle Proteins; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzymes; Gene Expression Regulation; Hodgkin Disease; Humans; Leukemia, B-Cell; Leupeptins; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Mice; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Proteins; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Substrate Specificity; Transcription Factors; Treatment Outcome	2002
Chemoprevention of lung cancer: soon daily practice? Expert review of anticancer therapy, 2003, Volume: 3, Issue:1 Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Carotenoids; Clinical Trials as Topic; Diet; Humans; Lung Neoplasms; Pyrazines; Retinoids; Selenium; Smoking; Vitamin E	2003
Proteasome inhibition: a new anti-inflammatory strategy. Journal of molecular medicine (Berlin, Germany), 2003, Volume: 81, Issue:4 Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury	2003
Anti-angiogenic and anti-tumor properties of proteasome inhibitors. Current cancer drug targets, 2005, Volume: 5, Issue:7 Topics: Acetylcysteine; Angiogenesis Inhibitors; Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Neoplasms; Neovascularization, Pathologic; Protease Inhibitors; Proteasome Inhibitors; Pyrazines	2005
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment. Current protein & peptide science, 2008, Volume: 9, Issue:3 Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Clinical Trials as Topic; Curcumin; Humans; Neoplasms; Pentacyclic Triterpenes; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Triterpenes; Ubiquitin	2008
Targeting the proteasome pathway. Expert opinion on therapeutic targets, 2009, Volume: 13, Issue:5 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Biological Products; Boronic Acids; Bortezomib; Drug Delivery Systems; Drug Discovery; Humans; Lactones; Neoplasms; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Structure-Activity Relationship; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitins	2009
[Classification and synthesis of ubiquitin-proteasome inhibitor]. Yao xue xue bao = Acta pharmaceutica Sinica, 2009, Volume: 44, Issue:12 Topics: Acetylcysteine; Antineoplastic Agents; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Multiple Myeloma; Peptides, Cyclic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Ubiquitin	2009

Trials

2 trial(s) available for acetylcysteine and pyrazines

Article	Year
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. Journal of the National Cancer Institute, 1999, Feb-17, Volume: 91, Issue:4 Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome	1999
Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:3 Topics: Acetylcysteine; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Pyrazines; Reference Values; Risk Assessment; Smoking; Thiones; Thiophenes	2001

Article

Year

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.

Journal of the National Cancer Institute, 1999, Feb-17, Volume: 91, Issue:4

Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome

1999

Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:3

Topics: Acetylcysteine; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Pyrazines; Reference Values; Risk Assessment; Smoking; Thiones; Thiophenes

2001

Other Studies

30 other study(ies) available for acetylcysteine and pyrazines

Article	Year
Mercapturic acid formation from 2-aminopyrazine in rats. Xenobiotica; the fate of foreign compounds in biological systems, 1992, Volume: 22, Issue:11 Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Mass Spectrometry; Pyrazines; Rats; Rats, Zucker	1992
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials. Journal of cellular biochemistry. Supplement, 1996, Volume: 25 Topics: Acetylcysteine; Adult; Anticarcinogenic Agents; Biomarkers, Tumor; Chemoprevention; China; Clinical Trials, Phase II as Topic; Cohort Studies; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenicity Tests; Mutagens; Netherlands; Pyrazines; Research Design; Smoking; Thiones; Thiophenes	1996
Proteasome inhibition measurements: clinical application. Clinical chemistry, 2000, Volume: 46, Issue:5 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cysteine Endopeptidases; Humans; In Vitro Techniques; Kinetics; Male; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2000
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia, 2000, Volume: 14, Issue:7 Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells	2000
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer research, 2001, Mar-15, Volume: 61, Issue:6 Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Biomarkers; DNA Adducts; DNA Damage; Eating; Hemoglobins; Inhalation Exposure; Lung; Male; Micronuclei, Chromosome-Defective; Nicotiana; Oxidation-Reduction; Plants, Toxic; Pyrazines; Rats; Rats, Sprague-Dawley; Smoke; Smoking; Thiones; Thiophenes; Tobacco Smoke Pollution; Weight Gain	2001
Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents. Mutation research, 2001, Jul-25, Volume: 494, Issue:1-2 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Chemoprevention; DNA Adducts; Eating; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Smoking; Thiones; Thiophenes; Weight Gain	2001
Imaging 26S proteasome activity and inhibition in living mice. Nature medicine, 2003, Volume: 9, Issue:7 Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Coleoptera; Cysteine Proteinase Inhibitors; Genes, Reporter; HeLa Cells; Humans; Kinetics; Leupeptins; Luciferases; Luminescent Measurements; Male; Mice; Mice, Nude; Molecular Biology; Peptide Hydrolases; Proteasome Endopeptidase Complex; Pyrazines; Transfection; Ubiquitin; Xenograft Model Antitumor Assays	2003
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jun-01, Volume: 10, Issue:11 Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intracellular Membranes; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oxidative Stress; Oxygen; Protease Inhibitors; Proteins; Proteoglycans; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Reactive Oxygen Species; Sodium Oxybate; Syndecan-1; Syndecans; Tumor Suppressor Proteins; Vorinostat; X-Linked Inhibitor of Apoptosis Protein	2004
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3 Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation	2006
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis, 2007, Volume: 28, Issue:2 Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Base Sequence; Biological Products; Blotting, Western; Cell Line, Tumor; Curcumin; Cysteine; DNA Modification Methylases; DNA Primers; DNA Repair Enzymes; Dose-Response Relationship, Drug; Fenretinide; Glutathione; Glutathione S-Transferase pi; Humans; Lymphocytes; Prodrugs; Pyrazines; RNA, Messenger; Silymarin; Thiones; Thiophenes; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins	2007
Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells. Immunology, 2007, Volume: 120, Issue:1 Topics: Acetylcysteine; Apoptosis; Boronic Acids; Bortezomib; Cell Differentiation; Chymases; Cysteine Proteinase Inhibitors; Dendritic Cells; Endocytosis; Humans; Interleukin-12; Lymphocyte Activation; Monocytes; Oligopeptides; Pinocytosis; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Receptors, Cell Surface	2007
Detection of a proteasome in Pneumocystis carinii and its modulation by specific proteasome inhibitors. The Journal of eukaryotic microbiology, 2006, Volume: 53 Suppl 1 Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Line; Coumarins; Genes, Fungal; HIV Protease Inhibitors; Humans; Lopinavir; Models, Animal; Oligopeptides; Pneumocystis carinii; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrimidinones; Rats	2006
Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits. Cancer, 2008, Feb-01, Volume: 112, Issue:3 Topics: Acetylcysteine; Apoptosis; B-Lymphocytes; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Endopeptidases; Drug Screening Assays, Antitumor; Humans; Interferon-gamma; Lymphoma; Multienzyme Complexes; Multiple Myeloma; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Subunits; Pyrazines	2008
Proteasome inhibition suppresses essential immune functions of human CD4+ T cells. Immunology, 2008, Volume: 124, Issue:2 Topics: Acetylcysteine; Antigens, CD; Apoptosis; Boronic Acids; Bortezomib; CD4-Positive T-Lymphocytes; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cytokines; Dose-Response Relationship, Immunologic; Humans; Immunosuppressive Agents; Lymphocyte Activation; NFATC Transcription Factors; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Translocation, Genetic; Tumor Suppressor Protein p53	2008
Redox homeostasis modulates the sensitivity of myeloma cells to bortezomib. British journal of haematology, 2008, Volume: 141, Issue:4 Topics: Acetylcysteine; Activating Transcription Factor 4; Antineoplastic Agents; Antioxidants; Boronic Acids; Bortezomib; Cell Death; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glutathione; Homeostasis; Humans; Multiple Myeloma; Neoplasm Proteins; Oxidation-Reduction; Protease Inhibitors; Pyrazines; Transcription Factor CHOP; Tumor Cells, Cultured	2008
Comparative protective effect of N-acetyl cysteine and tetramethylpyrazine in rats with gentamicin nephrotoxicity. Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Animals; Antioxidants; Body Weight; Creatinine; Gentamicins; Kidney Cortex; Male; Protective Agents; Protein Synthesis Inhibitors; Pyrazines; Rats; Rats, Wistar; Urea; Urodynamics	2009
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species. Leukemia, 2010, Volume: 24, Issue:1 Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Antibodies, Monoclonal; Boronic Acids; Bortezomib; Cell Line, Tumor; Humans; Hydroxamic Acids; Ki-1 Antigen; Proteasome Inhibitors; Pyrazines; Reactive Oxygen Species; Sulfonamides; Syndecan-1	2010
Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:1 Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; beta-Naphthoflavone; Chemoprevention; Cluster Analysis; Enzyme Inhibitors; Gene Expression; Indoles; Isothiocyanates; Lung; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes; Tobacco Smoke Pollution	2010
Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasome system in vitro. Veterinary pathology, 2010, Volume: 47, Issue:2 Topics: Acetylcysteine; Animals; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Immunohistochemistry; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Oligopeptides; PC12 Cells; Peripheral Nervous System Diseases; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Ubiquitin	2010
Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation. Molecular therapy : the journal of the American Society of Gene Therapy, 2010, Volume: 18, Issue:6 Topics: Acetylcysteine; Animals; Apoptosis; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Cytokines; HLA-DR3 Antigen; Lipopolysaccharides; Liver; Mice; Mice, Transgenic; NF-kappa B; Proteasome Inhibitors; Pyrazines; Superantigens; Systemic Inflammatory Response Syndrome	2010
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells. Cell biology and toxicology, 2011, Volume: 27, Issue:2 Topics: Acetylcysteine; Animals; Biological Assay; Boronic Acids; Bortezomib; Cell Extracts; Cells, Cultured; Chymotrypsin; High-Throughput Screening Assays; Inhibitory Concentration 50; Leupeptins; Mice; Models, Biological; Oligopeptides; Ornithine Decarboxylase; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Time Factors	2011
Delayed treatment with vitamin C and N-acetyl-L-cysteine protects Schwann cells without compromising the anti-myeloma activity of bortezomib. International journal of hematology, 2011, Volume: 93, Issue:6 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Autophagy; Boronic Acids; Bortezomib; Cell Line; Endoplasmic Reticulum; Free Radical Scavengers; Multiple Myeloma; Neuroprotective Agents; Peripheral Nervous System Diseases; Pyrazines; Rats; Schwann Cells	2011
Proteasomal inhibition restores biological function of mis-sense mutated dysferlin in patient-derived muscle cells. The Journal of biological chemistry, 2012, Mar-23, Volume: 287, Issue:13 Topics: Acetylcysteine; Alleles; Amino Acid Substitution; Antineoplastic Agents; Boronic Acids; Bortezomib; Cells, Cultured; Cysteine Proteinase Inhibitors; Distal Myopathies; Dysferlin; Humans; Membrane Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy; Muscular Dystrophies, Limb-Girdle; Mutation, Missense; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; RNA, Messenger	2012
Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:3 Topics: Acetylcysteine; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Calcium; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Humans; Male; Prostatic Neoplasms; Protease Inhibitors; Pyrazines; Transfection; Tumor Cells, Cultured	2012
Mitochondrial dysfunction and therapeutic approaches in respiratory and limb muscles of cancer cachectic mice. Experimental physiology, 2013, Volume: 98, Issue:9 Topics: Acetylcysteine; Animals; Antioxidants; Boronic Acids; Bortezomib; Cachexia; Diaphragm; Electron Transport Chain Complex Proteins; Female; Lung Neoplasms; MAP Kinase Signaling System; Mice; Mitochondria; Mitochondrial Diseases; Mitogen-Activated Protein Kinases; Muscle Strength; Muscle, Skeletal; NF-kappa B; Oxidative Stress; Pyrazines	2013
Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib. Leukemia, 2013, Volume: 27, Issue:10 Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Boronic Acids; Bortezomib; Cell Nucleolus; Cell Proliferation; Cysteine; Cytosol; Drug Resistance, Neoplasm; Flow Cytometry; Free Radical Scavengers; Humans; Leukemia, Myeloid, Acute; Mutation; Nuclear Proteins; Nucleophosmin; Oxides; Pyrazines; Reactive Oxygen Species; Tryptophan; Tumor Cells, Cultured	2013
Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons. Neurotoxicology, 2013, Volume: 39 Topics: Acetylcysteine; Animals; Antineoplastic Agents; Axonal Transport; Boronic Acids; Bortezomib; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Mammalian; Ganglia, Spinal; Microscopy, Electron, Transmission; Microtubules; Neurons; Organ Culture Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors	2013
Precolumn o-phthalaldehyde-N-acetyl-L-cysteine derivatization followed by RP-HPLC separation and fluorescence detection of sitagliptin enantiomers in rat plasma. Chirality, 2013, Volume: 25, Issue:12 Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Drug Stability; Fluorescent Dyes; Limit of Detection; Molecular Structure; o-Phthalaldehyde; Pyrazines; Rats; Sitagliptin Phosphate; Spectrometry, Fluorescence; Time Factors; Triazoles	2013
Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells. Experimental & molecular medicine, 2013, Oct-25, Volume: 45 Topics: 2-Methoxyestradiol; Acetylcysteine; Apoptosis; Boronic Acids; Bortezomib; Calcium; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Humans; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Pyrazines; Reactive Oxygen Species	2013
Sulfotransferase-catalyzed biotransformation of liguzinediol and comparison of its metabolism in different species using UFLC-QTOF-MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Jul-01, Volume: 1089 Topics: Acetylcysteine; Animals; Biotransformation; Catalysis; Cell Culture Techniques; Chromatography, High Pressure Liquid; Dogs; Haplorhini; Humans; Liver; Metabolome; Metabolomics; Molecular Structure; Pyrazines; Rats; Signal Transduction; Sulfotransferases; Tandem Mass Spectrometry	2018