acetylcysteine has been researched along with probenecid in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (21.74) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 9 (39.13) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Ignarro, LJ; Wood, KS | 1 |
| Boogaard, PJ; Commandeur, JN; Mulder, GJ; Nagelkerke, JF; Vermeulen, NP | 1 |
| Stevens, JL; Zhang, GH | 1 |
| Francis, JE; Smith, AG | 1 |
| Inoue, M; Morino, Y; Okajima, K | 1 |
| Dantzler, WH; Evans, KK; Wright, SH | 1 |
| Ishmael, J; Lock, EA | 1 |
| Ahmad, S; Zalups, RK | 1 |
| Bark, H; Choi, CH; Chung, JM; Kim, SH; Park, EK | 1 |
| Bayır, H; Chao, H; Clark, RS; Du, L; Empey, PE; Ji, J; Kochanek, PM | 1 |
| Bayir, H; Clark, RS; Daood, MJ; Empey, PE; Hagos, FT; Kochanek, PM; Nolin, TD; Ocque, JA; Poloyac, SM | 1 |
| Au, AK; Bayır, H; Bell, MJ; Clark, RSB; Empey, PE; Horvat, CM; Kochanek, PM; Nolin, TD; Poloyac, SM; Rosario, BL; Wisniewski, SR | 1 |
| Bayir, H; Bell, MJ; Clark, RSB; Empey, PE; Hagos, FT; Kochanek, PM; Ma, X; Poloyac, SM; Wang, P | 1 |
| Bell, MJ; Clark, RSB; Empey, PE; Kochanek, PM | 1 |
2 review(s) available for acetylcysteine and probenecid
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury.
Topics: Acetylcysteine; Blood-Brain Barrier; Brain; Brain Injuries, Traumatic; Child; Humans; Pilot Projects; Probenecid | 2023 |
2 trial(s) available for acetylcysteine and probenecid
| Article | Year |
|---|---|
Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adolescent; Antioxidants; Biomarkers; Body Temperature; Brain Injuries, Traumatic; Child; Child, Preschool; Double-Blind Method; Drug Administration Schedule; Female; Glasgow Coma Scale; Glasgow Outcome Scale; Humans; Intracranial Pressure; Intubation, Gastrointestinal; Male; Probenecid; Survival Analysis | 2017 |
Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.
Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adolescent; Brain Injuries, Traumatic; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Humans; Injury Severity Score; Metabolomics; Probenecid | 2018 |
19 other study(ies) available for acetylcysteine and probenecid
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites.
Topics: Acetylation; Acetylcysteine; Animals; Biological Transport; Chromatography, High Pressure Liquid; Cysteine; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Fluorinated; Inactivation, Metabolic; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred Strains; Subcellular Fractions | 1989 |
Transport and activation of S-(1,2-dichlorovinyl)-L-cysteine and N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine in rat kidney proximal tubules.
Topics: Acetylcysteine; Animals; Biological Transport; Biotransformation; Cysteine; Drug Interactions; In Vitro Techniques; Kidney Tubules, Proximal; Male; Probenecid; Rats; Rats, Inbred Strains; Sulfur Radioisotopes | 1989 |
Evidence for the active renal secretion of S-pentachlorophenyl-N-acetyl-L-cysteine by female rats.
Topics: Acetylcysteine; Animals; Bile; Feces; Female; Isoxazoles; Kidney; Male; Nitrobenzenes; Probenecid; Rats; Rats, Inbred F344; Sex Factors | 1983 |
Renal transtubular transport of mercapturic acid in vivo.
Topics: Acetylcysteine; Animals; Biological Transport; Kidney Tubules; Kinetics; Liver; Male; Probenecid; Rats | 1981 |
Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules.
Topics: Acetylcysteine; Animals; Anion Transport Proteins; Carrier Proteins; Cysteine; In Vitro Techniques; Kidney Tubules, Proximal; Mercuric Chloride; p-Aminohippuric Acid; Probenecid; Rabbits | 1995 |
The nephrotoxicity and hepatotoxicity of 1,1,2,2-tetrafluoroethyl-L-cysteine in the rat.
Topics: Acetylcysteine; Aminooxyacetic Acid; Animals; Butadienes; Cysteine; Dose-Response Relationship, Drug; Female; Hydrocarbons, Fluorinated; Ion Transport; Kidney Diseases; Male; Probenecid; Rats; Renal Agents | 1998 |
Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1.
Topics: Acetylcysteine; Amino Acids; Animals; Biological Transport; Cell Line; Cell Survival; Dogs; Dose-Response Relationship, Drug; Humans; Kidney; Methylmercury Compounds; Organic Anion Transport Protein 1; p-Aminohippuric Acid; Probenecid; Temperature; Transfection | 2005 |
Elevated reactive oxygen species but not glutathione regulate mercury resistance to AML-2/DX100 cells.
Topics: Acetylcysteine; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Hydrogen Peroxide; Imidazoles; Mercuric Chloride; Multidrug Resistance-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Probenecid; Pyridines; Pyrrolidines; Reactive Oxygen Species; Signal Transduction; Thiocarbamates | 2006 |
Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro.
Topics: Acetylcysteine; Animals; Brain Injuries, Traumatic; Cell Death; Cells, Cultured; Female; Glutathione; Male; Neurons; Neuroprotective Agents; Probenecid; Rats; Rats, Sprague-Dawley; Stress, Mechanical | 2016 |
Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine.
Topics: Acetylcysteine; Animals; Biological Transport; Brain; Drug Interactions; Organic Anion Transporters; Plasma; Probenecid; Rats; Rats, Sprague-Dawley | 2017 |