acetylcysteine has been researched along with paclitaxel in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.33) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 16 (53.33) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Baldin, V; Brichese, L; Chadebech, P; Valette, A; Vidal, S | 1 |
| Buchsbaum, D; Kimberly, R; Makhija, S; Ohtsuka, T; Oliver, P; Zhou, T | 1 |
| Bernhard, D; Csordas, A; Henderson, B; Kind, M; Rossmann, A; Wick, G | 1 |
| Alexandre, J; Batteux, F; Chéreau, C; Goldwasser, F; Guillevin, L; Laurent, A; Nicco, C; Weill, B | 1 |
| Al-Humadi, NH; Hu, S; Ma, JK; Yin, XJ; Zhao, H | 1 |
| Haikel, Y; Hassan, M; Hengge, UR; Selimovic, D | 1 |
| Hsu, PC; Hung, HC; Liao, YF; Liu, CC; Liu, GY; Tsay, GJ | 1 |
| Barton, D; Grothey, A; Kottschade, L; Loprinzi, C; Wolf, S | 1 |
| Meshkini, A; Yazdanparast, R | 1 |
| Abdulkadir, SA; Roh, M; van der Meer, R | 1 |
| Lyle, PA; Mitsopoulos, P; Suntres, ZE | 1 |
| Benbow, JH; DeGray, B; Ehrlich, BE | 1 |
| Barrière, DA; Busserolles, J; Chanteranne, D; Chapuis, L; Chauvin, MA; Dubray, C; Morio, B; Rieusset, J; Salles, J | 1 |
| Ai, X; Ding, W; Han, X; He, Z; Kou, L; Li, L; Lian, H; Liu, X; Ren, G; Sun, J; Sun, Y; Wang, S; Wang, Y; Wu, C; Zhang, T; Zhang, Y | 1 |
| Chen, XX; Gong, LH; Jiang, QW; Mei, XL; Pan, SS; Qin, WM; Qiu, JG; Shi, Z; Wang, H; Xue, YQ; Yan, XJ; Zheng, FY | 1 |
| Lee, C | 1 |
| Aller, P; Alvarez, L; Barasoain, I; Díaz, JF; González-Maya, L; Lastres, P; Redondo-Horcajo, M; Romero-Estrada, A; Sánchez-Carranza, JN | 1 |
| Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D | 1 |
| Asghar, S; Chen, Z; Huang, L; Jin, X; Ping, Q; Xiao, Y; Zhang, M | 1 |
| Asghar, S; Chen, Z; Hu, Z; Jin, X; Ping, Q; Shao, F; Xiao, Y; Zhang, M | 1 |
| Aboelhassan, R; El Wakeel, LM; Khalefa, HG; Shawki, MA | 1 |
| Bartos, P; Bartunkova, J; Chovanec, J; Cibula, D; Fucikova, J; Hraska, M; Hrnciarova, T; Kieszko, D; Klat, J; Knapp, P; Korolkiewicz, RP; Mallmann, P; Melichar, B; Minar, L; Novotny, Z; Pluta, M; Rob, L; Spacek, J; Spisek, R; Valha, P | 1 |
2 review(s) available for acetylcysteine and paclitaxel
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies.
Topics: Acetylcarnitine; Acetylcysteine; Anticonvulsants; Antidepressive Agents, Tricyclic; Antineoplastic Agents; Baclofen; Calcium; Glutamine; Humans; Infusions, Intravenous; Ketamine; Magnesium; Naphthalenes; Nootropic Agents; Paclitaxel; Peripheral Nervous System Diseases; Pyridines; Randomized Controlled Trials as Topic; Vitamin E | 2008 |
2 trial(s) available for acetylcysteine and paclitaxel
| Article | Year |
|---|---|
Evaluation of the effect of N-acetylcysteine on the prevention and amelioration of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled study.
Topics: Acetylcysteine; Adult; Aged; Antineoplastic Agents, Phytogenic; Biomarkers; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Lipid Peroxidation; Malondialdehyde; Middle Aged; Nerve Growth Factor; Paclitaxel; Peripheral Nervous System Diseases; Prospective Studies; Quality of Life | 2020 |
Safety and efficacy of dendritic cell-based immunotherapy DCVAC/OvCa added to first-line chemotherapy (carboplatin plus paclitaxel) for epithelial ovarian cancer: a phase 2, open-label, multicenter, randomized trial.
Topics: Acetylcysteine; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Ovarian Epithelial; Dendritic Cells; Female; Humans; Immunotherapy; Mice; Middle Aged; Paclitaxel; Young Adult | 2022 |
26 other study(ies) available for acetylcysteine and paclitaxel
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Leupeptins; Microtubules; Mitosis; Multienzyme Complexes; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway.
Topics: Acetylcysteine; Adenocarcinoma; Antibodies, Monoclonal; Antibody Specificity; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carrier Proteins; Caspases; Cisplatin; Cytochrome c Group; DNA Fragmentation; Doxorubicin; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Tumor Cells, Cultured | 2003 |
Cigarette smoke metal-catalyzed protein oxidation leads to vascular endothelial cell contraction by depolymerization of microtubules.
Topics: Acetylcysteine; Antioxidants; Atherosclerosis; Calcium; Catalysis; Cells, Cultured; Endothelial Cells; Humans; Interleukin-6; Interleukin-8; Metals; Microtubules; Nicotiana; Oxidative Stress; P-Selectin; Paclitaxel; Platelet Endothelial Cell Adhesion Molecule-1; Proteins; Smoke; Tubulin; Vasoconstriction | 2005 |
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Lung Neoplasms; Paclitaxel; Reactive Oxygen Species; Spectrometry, Fluorescence | 2006 |
Silica-induced apoptosis in alveolar macrophages: evidence of in vivo thiol depletion and the activation of mitochondrial pathway.
Topics: Acetylcysteine; Alkaloids; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzylisoquinolines; Caspase 3; Caspases; Cysteine; Cytochromes c; Disease Models, Animal; Glutathione; Inflammation Mediators; Macrophages, Alveolar; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria; Oxidative Stress; Paclitaxel; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Silicon Dioxide; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha | 2006 |
Taxol-induced mitochondrial stress in melanoma cells is mediated by activation of c-Jun N-terminal kinase (JNK) and p38 pathways via uncoupling protein 2.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Free Radical Scavengers; Humans; Ion Channels; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Melanoma; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Models, Biological; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Reactive Oxygen Species; Uncoupling Protein 2 | 2008 |
Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle; Cisplatin; Etoposide; Glutathione; HL-60 Cells; Humans; Leukemia; Membrane Potential, Mitochondrial; Ornithine Decarboxylase; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; Putrescine; Reactive Oxygen Species | 2008 |
Involvement of oxidative stress in taxol-induced apoptosis in chronic myelogenous leukemia K562 cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Antagonism; Drug Screening Assays, Antitumor; Flow Cytometry; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Reactive Oxygen Species; Superoxides | 2012 |
Tumorigenic polyploid cells contain elevated ROS and ARE selectively targeted by antioxidant treatment.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Cell Line; Drug Resistance, Neoplasm; Epithelial Cells; Female; Humans; Hydrogen Peroxide; Male; Mammary Glands, Human; Mitochondria; Mitosis; Paclitaxel; Polyploidy; Prostate; Reactive Oxygen Species | 2012 |
N-acetylcysteine modulates the cytotoxic effects of Paclitaxel.
Topics: Acetylcysteine; Adenocarcinoma; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Caspase 10; Caspase 3; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Humans; Paclitaxel; Reactive Oxygen Species | 2011 |
Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.
Topics: Acetylcysteine; Calcium Signaling; Calpain; Cell Line, Tumor; Humans; Mutation; Neuroblastoma; Neuronal Calcium-Sensor Proteins; Neurons; Neuropeptides; Paclitaxel; Point Mutation; Protease Inhibitors; Protein Isoforms; Signal Transduction; Thermodynamics | 2011 |
Paclitaxel therapy potentiates cold hyperalgesia in streptozotocin-induced diabetic rats through enhanced mitochondrial reactive oxygen species production and TRPA1 sensitization.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antineoplastic Agents, Phytogenic; Cold Temperature; Diabetes Mellitus, Experimental; Disease Models, Animal; Ganglia, Spinal; Glucose Tolerance Test; Glutathione Peroxidase; Hydrogen Peroxide; Hyperalgesia; Hypoxanthine Phosphoribosyltransferase; Male; Microscopy, Electron, Transmission; Mitochondria; Paclitaxel; Pain Measurement; Pain Threshold; Phospholipid Hydroperoxide Glutathione Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sciatic Nerve; Sensory Receptor Cells; Streptozocin; Time Factors; TRPA1 Cation Channel; TRPC Cation Channels | 2012 |
Enhanced oral delivery of paclitaxel using acetylcysteine functionalized chitosan-vitamin E succinate nanomicelles based on a mucus bioadhesion and penetration mechanism.
Topics: Acetylcysteine; Animals; Chitosan; Drug Carriers; Micelles; Mucus; Paclitaxel; Rats; Rats, Sprague-Dawley; Spectrometry, X-Ray Emission; Thermogravimetry; Vitamin E | 2013 |
Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cisplatin; Dioxolanes; Drug Synergism; Female; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Ovarian Neoplasms; Paclitaxel; Reactive Oxygen Species | 2014 |
Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.
Topics: Acetylcysteine; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Oncogene Protein v-akt; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction | 2015 |
Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; G2 Phase Cell Cycle Checkpoints; Gallic Acid; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Paclitaxel; Reactive Oxygen Species | 2018 |
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.
Topics: Acetylcysteine; Animals; Antibodies; Cells, Cultured; Clodronic Acid; Coculture Techniques; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Imidazoles; Macrophages; Male; Membrane Proteins; Mice; Minocycline; Neurons; p300-CBP Transcription Factors; Paclitaxel; Peripheral Nervous System Diseases; Phosphoproteins; Phosphorylation; Proline; Pyridines; Pyruvates; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Recombinant Proteins; Sciatic Nerve; Thiocarbamates; Thrombomodulin; Up-Regulation | 2018 |
N-acetylcysteine modified hyaluronic acid-paclitaxel conjugate for efficient oral chemotherapy through mucosal bioadhesion ability.
Topics: Acetylcysteine; Adhesiveness; Administration, Oral; Animals; Drug Liberation; Gastrointestinal Tract; Humans; Hyaluronic Acid; Male; MCF-7 Cells; Micelles; Mucins; Mucous Membrane; Oxidation-Reduction; Paclitaxel; Particle Size; Rats, Sprague-Dawley; Static Electricity; Sulfhydryl Compounds; Tissue Distribution | 2018 |
The enhancing effect of N-acetylcysteine modified hyaluronic acid-octadecylamine micelles on the oral absorption of paclitaxel.
Topics: Acetylcysteine; Administration, Oral; Amines; Animals; Cell Line, Tumor; Drug Carriers; Drug Delivery Systems; Humans; Hyaluronic Acid; Male; Micelles; Paclitaxel; Rats; Tissue Distribution | 2019 |