acetylcysteine and nitroglycerin

acetylcysteine has been researched along with nitroglycerin in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (32.53)	18.7374
1990's	41 (49.40)	18.2507
2000's	10 (12.05)	29.6817
2010's	5 (6.02)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blaschke, TF; Hoffman, BB; Kongpatanakul, S; Vincent, J	1
Iversen, HK	1
de Servi, S; Eleuteri, E; Ghio, S; Montemartini, C; Perotti, R; Specchia, G	2
Horowitz, JD	2
Matsuzaki, T; Sakanashi, M	1
Auclert, L; Blin, P; Guérin, C; Guérin, F; Pellois, A; Touiza, K; Weber, S	1
Lawson, DL; Mehta, JL; Mehta, P; Nichols, WW	1
Chern, WH; Han, BJ; Lee, FW; Shaffer, JE	1
Folts, JD; Loscalzo, J; Stamler, J	1
Chong, S; Fung, HL	1
Dupuis, J; Lalonde, G; Lemieux, R; Rouleau, JL	1
Boobis, AR; Davies, DS; Newman, CM; Taylor, GW; Warren, JB	1
Henderson, AH; Hogan, JC; Lewis, MJ	3
Ignarro, LJ; Wood, KS	1
Abdollah, A; Armstrong, PW; Moffat, JA	1
Holzmann, S; Kukovetz, WR	1
Bassenge, E; Holtz, J; Münzel, T; Stewart, DJ	2
Aldershvile, J; Klarlund, K; Svendsen, JH; Waldorff, S	1
Henry, PJ; Horowitz, JD; Louis, WJ	1
Bodemann, T; Hochrein, H; Langescheid, C	1
Bassenge, E; Holtz, J; Mülsch, A; Münzel, T; Stewart, DJ	1
Drummer, OH; Henry, PJ; Horowitz, JD	1
Akatsuka, N; Hara, K; Moroi, M; Ochiai, M; Ohno, M; Tsuneyoshi, H	1
Hawlicek, J; Kalenbach, M; Kirsten, N; Kober, G; Krause, A; Satter, P; Schneider, W; von Loh, D; Weyenmeyer, T	1
Loscalzo, J	1
Ohba, Y; Sakai, K; Shiraki, Y	1
Flaherty, JT	1
Hillis, LD; Kennedy, PL; Wells, PJ; Winniford, MD	1
Gottlieb, SS; Kessler, PD; Lee, WH; Medina, N; Packer, M; Yushak, M	1
Black, WH; Hillis, LD; Lee, HR; Levine, BD; May, DC; Popma, JJ; Schaefer, S	1
Feelisch, M; Noack, E	1
Bertel, O; Marx, BE; Noll, G	1
Antman, EM; Fish, RD; Henry, CA; Horowitz, JD; Louis, WJ; Smith, TW; Syrjanen, ML	2
Chong, S; Fung, HL; Hough, K; Kakemi, M; Kowaluk, E	1
Cunningham, M; Loscalzo, J; Stamler, J	1
Antman, EM; Barry, WH; Horowitz, JD; Lorell, BH; Smith, TW	1
Castresana, MR; Jollow, DJ; McDonald, MH; Newman, WH; Zhang, LM	1
Arstall, MA; Betts, WH; Horowitz, JD; Stafford, I; Yang, J	1
Agvald, P; Gustafsson, LE; Persson, MG	2
Campana, C; Diotallevi, P; Eleuteri, E; Ferrario, M; Ghio, S; Montemartini, C; Mussini, A; Poli, A; Specchia, G	1
Aldershvile, J; Anderson, ME; Boesgaard, S; Loft, S; Meister, A; Poulsen, HE	1
Aldershvile, J; Boesgaard, S; Frandsen, H; Iversen, HK; Kastrup, J; Poulsen, HE; Wroblewski, H	1
Anggard, E; Pistelli, A; Salvemini, D	1
Mollace, V; Pistelli, A; Salvemini, D	1
Pistelli, A; Salvemini, D; Vane, J	1
Arnet, U; Lüscher, TF; Siebenmann, R; Stulz, P; Turina, M; von Segesser, LK; Yang, Z	1
Bando, T; Hirata, T; Kosaka, S; Liu, CJ; Wada, H	1
Fukuse, T; Hirata, T; Hitomi, S; Inui, K; Kosaka, S; Liu, CJ; Ueda, M; Wada, H; Yokomise, H	1
Fukuse, T; Hirata, T; Hitomi, S; Liu, CJ; Ueda, Y; Wada, H	1
Aldershvile, J; Boesgaard, S; Laursen, JB; Poulsen, HE	1
Simon, K; Szépvölgyi, A	1
Chirkov, YY; Horowitz, JD	1
Haught, WH; Lawson, DL; Mehta, JL; Mehta, P	1
Hagendorff, A; Jung, W; Lüderitz, B; Pizzulli, L; Zirbes, M	1
Boles, K; Creager, MA; Roddy, MA; Stamler, JS	1
Ardissino, D; Bertocchi, F; Demicheli, G; Falcone, C; Ghio, S; Marinoni, G; Merlini, PA; Montemartini, C; Mussini, A; Savonitto, S; Zanini, P	1
Imai, S; Ishibashi, T; Kitagawa, T	1
Kanki, H; Nishikawa, Y; Ogawa, S	1
Beltrame, JF; Brennan, RJ; Horowitz, JD; Hunt, A; Moran, JL; Unger, SA; Zeitz, CJ	1
Colombo, A; Licciardello, L; Lodola, E; Marchetti, G	1
Ikeda, U; Ishibashi, S; Kawasaki, K; Shimada, K; Tate, Y	1
Buikema, H; Crijns, HJ; de Zeeuw, D; Monnink, SH; Tio, RA; van Gilst, WH	1
Birnboim, HC; Privora, H	1
Andrews, NP; Prasad, A; Quyyumi, AA	1
Deng, HW; Jiang, JL; Li, YJ; Peng, J; Zhou, ZH	1
Anfossi, G; Massucco, P; Mattiello, L; Russo, I; Trovati, M	1
Diallo, AS; Lobysheva, I; Muller, B; Sarr, M; Schini-Kerth, VB; Stoclet, JC	1
Cordan, J; Sağ, S; Senturk, T; Serdar, A; Serdar, Z; Yesilbursa, D	1
Chen, YR; Guo, R; Jiang, DJ; Li, YJ; Nie, SD; Shan, W; Shi, RZ; Zhang, Z; Zhou, Z	1
Akcar, N; Sahin, G; Yalcin, AU	1
Bai, YP; Chen, YR; Jiang, DJ; Li, YJ; Shi, RZ; Tang, ZY; Xiao, HB; Zhang, GG	1
Doki, Y; Eguchi, H; Ito, T; Kobayashi, S; Machida, T; Marubashi, S; Mori, M; Nagano, H; Ohmura, Y; Sawa, Y; Tanemura, M; Tanida, T; Wada, H	1
Lim, GB	1
Ebi, N; Hamada, E; Kinjo, T; Kobayashi, N; Miyagi-Shiohira, C; Nakashima, Y; Noguchi, H; Saitoh, I; Tamaki, Y; Watanabe, M	1

Reviews

7 review(s) available for acetylcysteine and nitroglycerin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Role of nitrates in unstable angina pectoris. The American journal of cardiology, 1992, Sep-24, Volume: 70, Issue:8 Topics: Acetylcysteine; Angina, Unstable; Drug Therapy, Combination; Humans; Nitrates; Nitroglycerin	1992
[Evaluation of tolerance during intravenous administration of low dose of isosorbide dinitrate in the treatment of unstable angina]. Archives des maladies du coeur et des vaisseaux, 1992, Volume: 85, Issue:1 Topics: Acetylcysteine; Adult; Aged; Angina, Unstable; Blood Pressure; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Tachyphylaxis	1992
Thiol-containing agents in the management of unstable angina pectoris and acute myocardial infarction. The American journal of medicine, 1991, Sep-30, Volume: 91, Issue:3C Topics: Acetylcysteine; Angina, Unstable; Drug Therapy, Combination; Humans; Myocardial Infarction; Nitroglycerin; Platelet Aggregation; Sulfhydryl Compounds	1991
Nitrate action on epicardial coronary arteries and tolerance: new aspects based on longterm glyceryl trinitrate infusions in dogs. European heart journal, 1989, Volume: 10 Suppl F Topics: Acetylcysteine; Animals; Coronary Vessels; Dogs; Drug Administration Schedule; Drug Interactions; Drug Tolerance; Endothelium, Vascular; Hemodynamics; Infusions, Intravenous; Nitroglycerin; Vasodilation	1989
Use of N-acetylcysteine in the management of coronary artery diseases. Cardiologia (Rome, Italy), 1999, Volume: 44, Issue:7 Topics: Acetylcysteine; Angina, Unstable; Animals; Clinical Trials as Topic; Coronary Disease; Drug Evaluation, Preclinical; Drug Therapy, Combination; Free Radical Scavengers; Humans; Nitroglycerin; Vasodilator Agents	1999
Pharmacotherapy: NAC plus nitrate therapy in PCI. Nature reviews. Cardiology, 2017, Volume: 14, Issue:8 Topics: Acetylcysteine; Drug Therapy, Combination; Humans; Myocardial Infarction; Nitroglycerin; Percutaneous Coronary Intervention; Postoperative Complications; Preoperative Care; Vasodilator Agents	2017

Trials

17 trial(s) available for acetylcysteine and nitroglycerin

Article	Year
N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:2 Topics: Acetylcysteine; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Female; Forearm; Headache; Hemodynamics; Humans; Male; Nitroglycerin; Skull; Temporal Arteries; Time Factors; Vasodilation	1992
[Evaluation of tolerance during intravenous administration of low dose of isosorbide dinitrate in the treatment of unstable angina]. Archives des maladies du coeur et des vaisseaux, 1992, Volume: 85, Issue:1 Topics: Acetylcysteine; Adult; Aged; Angina, Unstable; Blood Pressure; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Tachyphylaxis	1992
Chronic administration of N-acetylcysteine fails to prevent nitrate tolerance in patients with stable angina pectoris. British journal of clinical pharmacology, 1990, Volume: 30, Issue:4 Topics: Acetylcysteine; Administration, Oral; Aged; Angina Pectoris; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin	1990
N-acetylcysteine modifies the acute effects of isosorbide-5-mononitrate in angina pectoris patients evaluated by exercise testing. Journal of cardiovascular pharmacology, 1989, Volume: 13, Issue:2 Topics: Acetylcysteine; Administration, Sublingual; Adult; Angina Pectoris; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Exercise Test; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitroglycerin; Random Allocation	1989
Glyceryl trinitrate and platelet aggregation: effects of N-acetyl-cysteine. British journal of clinical pharmacology, 1989, Volume: 27, Issue:5 Topics: Acetylcysteine; Adenosine Diphosphate; Adult; Double-Blind Method; Humans; Male; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Random Allocation	1989
N-acetylcysteine fails to attenuate haemodynamic tolerance to glyceryl trinitrate in healthy volunteers. British journal of clinical pharmacology, 1989, Volume: 28, Issue:4 Topics: Acetylcysteine; Adult; Blood Pressure; Double-Blind Method; Drug Tolerance; Heart Rate; Hemodynamics; Humans; Male; Nitroglycerin; Randomized Controlled Trials as Topic	1989
Combined use of nitroglycerin and N-acetylcysteine in the management of unstable angina pectoris. Circulation, 1988, Volume: 77, Issue:4 Topics: Acetylcysteine; Angina Pectoris; Angina, Unstable; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypotension; Male; Myocardial Infarction; Nitroglycerin; Random Allocation; Risk Factors	1988
Nitroglycerine/N-acetylcysteine in the management of unstable angina pectoris. European heart journal, 1988, Volume: 9 Suppl A Topics: Acetylcysteine; Angina Pectoris; Angina, Unstable; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypotension; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin; Random Allocation	1988
N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects. Circulation, 1995, Nov-15, Volume: 92, Issue:10 Topics: Acetylcysteine; Cardiac Catheterization; Drug Synergism; Drug Therapy, Combination; Female; Fibrinolytic Agents; Free Radical Scavengers; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion; Nitroglycerin; Oxidative Stress; Streptokinase; Time Factors; Vasodilator Agents	1995
[Different susceptibilities to the development of nitroglycerin tolerance in the human peripheral venous and arterial circulations]. Cardiology, 1994, Volume: 84 Suppl 1 Topics: Acetylcysteine; Analysis of Variance; Arteries; Blood Circulation; Coronary Disease; Drug Interactions; Drug Tolerance; Hemodynamics; Humans; Infusions, Intravenous; Nitroglycerin; Time Factors; Veins	1994
Altered peripheral vasodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine. Journal of the American College of Cardiology, 1994, Volume: 23, Issue:1 Topics: Acetylcysteine; Adult; Arteries; Blood Vessels; Double-Blind Method; Drug Synergism; Hemodynamics; Humans; Infusions, Intravenous; Male; Microcirculation; Nitroglycerin; Vasodilation; Veins	1994
N-acetylcysteine attenuates nitroglycerin tolerance in patients with angina pectoris and normal left ventricular function. The American journal of cardiology, 1997, Jan-01, Volume: 79, Issue:1 Topics: Acetylcysteine; Aged; Angina Pectoris; Blood Pressure; Blood Volume; Drug Tolerance; Female; Free Radical Scavengers; Hematocrit; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Ventricular Function, Left	1997
Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. Journal of the American College of Cardiology, 1997, Volume: 29, Issue:5 Topics: Acetylcysteine; Administration, Cutaneous; Angina, Unstable; Coronary Angiography; Double-Blind Method; Drug Tolerance; Electrocardiography; Free Radical Scavengers; Humans; Nitroglycerin; Treatment Outcome; Vasodilator Agents	1997
Differential effects of N-acetylcysteine on nitroglycerin- and nicorandil-induced vasodilation in human coronary circulation. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:1 Topics: Acetylcysteine; Coronary Circulation; Coronary Disease; Coronary Vessels; Female; Free Radical Scavengers; Hemodynamics; Humans; Male; Middle Aged; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents	1998
Nitrate therapy is an alternative to furosemide/morphine therapy in the management of acute cardiogenic pulmonary edema. Journal of cardiac failure, 1998, Volume: 4, Issue:4 Topics: Acetylcysteine; Acute Disease; Diuretics; Drug Tolerance; Female; Free Radical Scavengers; Furosemide; Humans; Male; Morphine; Nitroglycerin; Prospective Studies; Pulmonary Edema; Treatment Outcome	1998
Effect of N-acetylcysteine on oxidative stress and ventricular function in patients with myocardial infarction. Heart and vessels, 2006, Volume: 21, Issue:1 Topics: Acetylcysteine; Adult; Aged; Biomarkers; Creatine Kinase, MB Form; Drug Therapy, Combination; Echocardiography, Doppler; Female; Fibrinolytic Agents; Free Radical Scavengers; Humans; Male; Malondialdehyde; Middle Aged; Myocardial Infarction; Nitroglycerin; Oxidative Stress; Research Design; Streptokinase; Stroke Volume; Treatment Outcome; Vasodilator Agents; Ventricular Function, Left; Ventricular Remodeling	2006
Effect of N-acetylcysteine on endothelial dysfunction in dialysis patients. Blood purification, 2007, Volume: 25, Issue:4 Topics: Acetylcysteine; Adult; Antioxidants; Brachial Artery; Cardiovascular Diseases; Endothelium, Vascular; Female; Hemorheology; Humans; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Oxidative Stress; Renal Dialysis; Ultrasonography; Uremia; Vasodilation	2007

Other Studies

60 other study(ies) available for acetylcysteine and nitroglycerin

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Desensitization of nitrate-induced venodilation: reversal with oral N-acetylcysteine in humans. Journal of cardiovascular pharmacology, 1992, Volume: 20, Issue:6 Topics: Acetylcysteine; Adult; Blood Pressure Determination; Dose-Response Relationship, Drug; Drug Tolerance; Female; Hand; Humans; Isosorbide Dinitrate; Male; Nitroglycerin; Regional Blood Flow; Vasodilation	1992
Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration. Circulation, 1992, Volume: 86, Issue:3 Topics: Acetylcysteine; Arteries; Blood Pressure; Blood Volume; Drug Tolerance; Female; Heart Rate; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Male; Middle Aged; Nitroglycerin; Vascular Resistance; Veins	1992
Comparison of the development of tolerance to nitroglycerin in aortic preparations isolated from non-diabetic and diabetic rats. Heart and vessels, 1992, Volume: 7, Issue:1 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Glucose; Culture Techniques; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; Drug Tolerance; Glycated Hemoglobin; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Rats; Rats, Inbred Strains; Vasodilation; Vasodilator Agents	1992
Captopril-induced reversal of nitroglycerin tolerance: role of sulfhydryl group vs. ACE-inhibitory activity. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:3 Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Captopril; Cyclic GMP; Drug Tolerance; Enalaprilat; Nitroglycerin; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Vasodilation	1991
Lack of tolerance to a 24-hour infusion of S-nitroso N-acetylpenicillamine (SNAP) in conscious rabbits. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1 Topics: Acetylcholine; Acetylcysteine; Animals; Body Weight; Consciousness; Dose-Response Relationship, Drug; Drug Tolerance; Erythrocyte Aggregation; Hematocrit; Hemodynamics; Male; Nitroglycerin; Nitroprusside; Penicillamine; Rabbits; S-Nitroso-N-Acetylpenicillamine; Time Factors; Vasodilator Agents	1992
Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation, 1991, Volume: 83, Issue:6 Topics: Acetylcysteine; Animals; Blood Coagulation; Blood Platelets; Coronary Circulation; Dogs; Female; Infusions, Intravenous; Male; Nitroglycerin; Periodicity; Time Factors	1991
Biochemical and pharmacological interactions between nitroglycerin and thiols. Effects of thiol structure on nitric oxide generation and tolerance reversal. Biochemical pharmacology, 1991, Sep-12, Volume: 42, Issue:7 Topics: Acetylcysteine; Animals; Aorta; Benzoates; Blood; Buffers; Culture Media; Culture Techniques; Cysteine; Drug Tolerance; Hot Temperature; Humans; Nitric Oxide; Nitroglycerin; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Thimerosal	1991
Tolerance to intravenous nitroglycerin in patients with congestive heart failure: role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine. Journal of the American College of Cardiology, 1990, Volume: 16, Issue:4 Topics: Acetylcysteine; Blood Pressure; Blood Volume; Drug Tolerance; Heart Failure; Humans; Infusions, Intravenous; Male; Middle Aged; Neurotransmitter Agents; Nitroglycerin; Vascular Resistance	1990
Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-L- but not N-acetyl-D-cysteine. British journal of pharmacology, 1990, Volume: 99, Issue:4 Topics: Acetylcysteine; Animals; Blood Pressure; Drug Tolerance; Male; Nitroglycerin; Nitroprusside; Rats; Rats, Inbred Strains; Stereoisomerism	1990
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase. The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11 Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine	1987
N-acetylcysteine does not modify nitroglycerin-induced tolerance in canine vascular rings. Journal of cardiovascular pharmacology, 1987, Volume: 9, Issue:4 Topics: Acetylcysteine; Animals; Dogs; Drug Interactions; Drug Tolerance; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin	1987
Cyclic GMP in nicorandil-induced vasodilatation and tolerance development. Journal of cardiovascular pharmacology, 1987, Volume: 10 Suppl 8 Topics: Acetylcysteine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitrate; Niacinamide; Nicorandil; Nitroglycerin; Vasodilation; Vasodilator Agents	1987
Discrepancy between initial and steady-state resistance vessel responsiveness to short-term nitroglycerin exposure in the hindlimb of conscious dogs. Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:2 Topics: Acetylcysteine; Animals; Arteries; Arterioles; Blood Pressure; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Homeostasis; Leg; Male; Nitroglycerin; Prostaglandins; Sympathetic Nervous System; Vascular Resistance; Vasodilation	1988
Determinants of in vitro nitroglycerin tolerance induction and reversal: influence of dose regimen, nitrate-free period, and sulfhydryl supplementation. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:1 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcysteine; Animals; Cattle; Drug Tolerance; In Vitro Techniques; Muscle Relaxation; Nitrates; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Sulfhydryl Compounds	1989
[Nitrate tolerance and its management by N-acetylcysteine (studies of patients with severe chronic heart failure)]. Zeitschrift fur Kardiologie, 1989, Volume: 78, Issue:5 Topics: Acetylcysteine; Cardiomyopathy, Dilated; Coronary Disease; Drug Therapy, Combination; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin	1989
Failure of the sulfhydryl donor N-acetylcysteine (NAC) to reverse nitrate tolerance in large epicardial arteries and the venous capacitance system of the dog. Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 2 Topics: Acetylcysteine; Animals; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Drug Tolerance; Muscle, Smooth, Vascular; Nitroglycerin; Sulfhydryl Compounds; Vascular Resistance; Venous Pressure	1989
S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators. British journal of pharmacology, 1989, Volume: 98, Issue:3 Topics: Acetylcysteine; Animals; Ascorbic Acid; Cattle; Chromatography, High Pressure Liquid; Coronary Vessels; Cystine; Drug Tolerance; In Vitro Techniques; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Vasodilator Agents	1989
Inhibition of development of tolerance to nitroglycerin by preventive administration of N-acetylcysteine in rats. Japanese heart journal, 1989, Volume: 30, Issue:5 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; In Vitro Techniques; Male; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilation	1989
[Isolated human venous segments as a model for the study of problems of nitrate tolerance]. Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 2 Topics: Acetylcysteine; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Humans; Isosorbide Dinitrate; Muscle, Smooth, Vascular; Nitroglycerin; Saphenous Vein; Vascular Resistance; Vasodilation	1989
N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. The Journal of clinical investigation, 1985, Volume: 76, Issue:2 Topics: Acetylcysteine; Adenosine Diphosphate; Cyclic AMP; Drug Synergism; Enzyme Activation; Glutathione; Guanylate Cyclase; Humans; In Vitro Techniques; Nitroglycerin; Platelet Aggregation; Time Factors	1985
Comparative vasorelaxing profiles of nicorandil, isosorbide dinitrate and nitroglycerin in isolated coronary arteries of the dog. Japanese journal of pharmacology, 1987, Volume: 45, Issue:3 Topics: Acetylcysteine; Animals; Coronary Vessels; Dinoprost; Dogs; Endothelium; Female; In Vitro Techniques; Isosorbide Dinitrate; Male; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Chloride; Prostaglandins F; Vasodilator Agents	1987
Hemodynamic attenuation and the nitrate-free interval: alternative dosing strategies for transdermal nitroglycerin. The American journal of cardiology, 1985, Dec-27, Volume: 56, Issue:17 Topics: Acetylcysteine; Administration, Oral; Administration, Topical; Angina Pectoris; Angina, Unstable; Animals; Blood Vessels; Cheek; Cyclic GMP; Drug Administration Schedule; Drug Tolerance; Electrocardiography; Endothelium; Exercise Test; Hemodynamics; Humans; Infusions, Parenteral; Isosorbide Dinitrate; Nitroglycerin; Prostaglandins; Vascular Resistance	1985
Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine. Circulation, 1986, Volume: 73, Issue:1 Topics: Acetylcysteine; Adult; Aged; Blood Pressure; Coronary Circulation; Coronary Vessels; Drug Synergism; Female; Heart Rate; Humans; Infusions, Parenteral; Male; Middle Aged; Nitroglycerin; Vasodilation	1986
Prevention and reversal of nitrate tolerance in patients with congestive heart failure. The New England journal of medicine, 1987, Sep-24, Volume: 317, Issue:13 Topics: Acetylcysteine; Administration, Oral; Adult; Aged; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Sulfhydryl Compounds	1987
In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. The New England journal of medicine, 1987, Sep-24, Volume: 317, Issue:13 Topics: Acetylcysteine; Adult; Aged; Arteries; Coronary Circulation; Coronary Disease; Coronary Vessels; Drug Tolerance; Female; Humans; Infusions, Intravenous; Injections, Intra-Arterial; Male; Middle Aged; Nitroglycerin; Sulfhydryl Compounds	1987
Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. European journal of pharmacology, 1987, Oct-27, Volume: 142, Issue:3 Topics: Acetylcysteine; Benzoates; Biological Products; Cysteine; Hemoglobins; Iron; Luminescent Measurements; Nitric Oxide; Nitroglycerin; Nitroprusside; Sulfhydryl Compounds; Thimerosal; Vasodilator Agents	1987
Reversal of nitrate tolerance with N-acetylcysteine. The New England journal of medicine, 1988, Mar-10, Volume: 318, Issue:10 Topics: Acetylcysteine; Drug Tolerance; Humans; Nitroglycerin	1988
Mechanisms for the pharmacologic interaction of organic nitrates with thiols. Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcysteine. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:2 Topics: Acetylcysteine; Animals; Aorta; Blood Pressure; Glutathione; Humans; In Vitro Techniques; Male; Metabolic Clearance Rate; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Rats; Rats, Inbred Strains; Serine; Vasodilation	1988
Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation. The American journal of cardiology, 1988, Sep-01, Volume: 62, Issue:7 Topics: Acetylcysteine; Aged; Aged, 80 and over; Blood Platelets; Coronary Disease; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Nitroglycerin; Oxidation-Reduction; Platelet Aggregation; Sulfhydryl Compounds	1988
Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine. Circulation, 1983, Volume: 68, Issue:6 Topics: Acetylcysteine; Adult; Blood Pressure; Cardiac Catheterization; Drug Synergism; Enzyme Activation; Female; Guanylate Cyclase; Humans; Male; Middle Aged; Nitroglycerin; Oxidation-Reduction; Sulfhydryl Compounds; Vasodilator Agents	1983
Tolerance to nitroglycerin in vascular smooth muscle cells is not affected by the level of intracellular glutathione or L-cysteine. Anesthesia and analgesia, 1995, Volume: 81, Issue:6 Topics: Acetylcysteine; Animals; Cyclic GMP; Cysteine; Cytoplasm; Drug Tolerance; Free Radical Scavengers; Glutathione; Muscle, Smooth, Vascular; Nitroglycerin; Sulfhydryl Reagents; Swine; Vasodilator Agents	1995
Rapid tolerance to formation of authentic NO from nitroglycerin in vivo. Agents and actions. Supplements, 1995, Volume: 45 Topics: Acetylcysteine; Animals; Arginine; Cysteine; Drug Tolerance; Glutathione; Hemodynamics; Infusions, Intravenous; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pulmonary Circulation; Rabbits	1995
Haemodynamic effects of glyceryl trinitrate during continuous 24 hour infusion in patients with heart failure. British heart journal, 1994, Volume: 72, Issue:2 Topics: Acetylcysteine; Adult; Blood Pressure; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Nitroglycerin; Time Factors; Vascular Resistance	1994
Detection of nitric oxide in exhaled air during administration of nitroglycerin in vivo. British journal of pharmacology, 1994, Volume: 111, Issue:3 Topics: Acetylcysteine; Adenosine; Animals; Arginine; Blood Pressure; Cysteine; Glutathione; Heart Rate; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pulmonary Artery; Pulmonary Veins; Rabbits; Vascular Resistance	1994
Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circulation research, 1994, Volume: 74, Issue:1 Topics: Acetylcysteine; Animals; Arteries; Drug Tolerance; Female; Nitrates; Nitroglycerin; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Veins	1994
Vascular and anti-platelet actions of 1,2- and 1,3-glyceryl dinitrate. British journal of pharmacology, 1993, Volume: 110, Issue:3 Topics: Acetylcysteine; Animals; Benzoates; Biotransformation; Blood Platelets; Cattle; Drug Synergism; Endothelium, Vascular; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfhydryl Compounds; Thimerosal; Vasodilator Agents	1993
Release of nitric oxide from glyceryl trinitrate by captopril but not enalaprilat: in vitro and in vivo studies. British journal of pharmacology, 1993, Volume: 109, Issue:2 Topics: Acetylcysteine; Animals; Captopril; Cattle; Enalapril; Endothelium, Vascular; Glutathione; Humans; In Vitro Techniques; Isosorbide Dinitrate; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Rats; Rats, Wistar; Vasodilator Agents	1993
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non-tolerant smooth muscle and endothelial cells. British journal of pharmacology, 1993, Volume: 108, Issue:1 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Cyclic GMP; Endothelium, Vascular; Humans; In Vitro Techniques; Male; Metyrapone; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Proadifen; Rabbits; Sulfobromophthalein	1993
Development of nitrate tolerance in human arteries and veins: comparison of nitroglycerin and SPM 5185. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:3 Topics: Acetylcysteine; Arginine; Dipeptides; Drug Tolerance; Free Radical Scavengers; Humans; In Vitro Techniques; Isometric Contraction; Mammary Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Saphenous Vein; Vasodilator Agents	1995
Effective 30-hour preservation of canine lungs with modified ET-Kyoto solution. The Annals of thoracic surgery, 1996, Volume: 61, Issue:4 Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Bucladesine; Dogs; Drug Evaluation, Preclinical; Ethanol; Gluconates; Glutathione; Hydroxyethyl Starch Derivatives; Insulin; Lung; Lung Transplantation; Nitroglycerin; Organ Preservation; Organ Preservation Solutions; Phosphates; Propylene Glycol; Propylene Glycols; Raffinose; Random Allocation; Reperfusion; Solutions; Time Factors; Trehalose	1996
New ET-Kyoto solution containing N-acetylcysteine, nitroglycerin, and dibutyryl cyclic AMP provides reliable 30-hour canine lung preservation. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Acetylcysteine; Adenosine; Allopurinol; Analysis of Variance; Animals; Bucladesine; Dogs; Endothelium, Vascular; Gluconates; Glutathione; Hydroxyethyl Starch Derivatives; Insulin; Ischemia; Lung; Lung Transplantation; Microscopy, Electron, Scanning; Nitroglycerin; Organ Preservation; Organ Preservation Solutions; Oxygen; Phosphates; Raffinose; Time Factors; Trehalose	1996
Effect of new ET-Kyoto solution on 17-hour lung preservation in isolated rat lungs. Transplantation proceedings, 1996, Volume: 28, Issue:3 Topics: Acetylcysteine; Analysis of Variance; Animals; Bucladesine; Gluconates; Hydroxyethyl Starch Derivatives; Lung; Male; Nitroglycerin; Organ Preservation; Phosphates; Rats; Rats, Inbred Lew; Reperfusion; Respiratory Function Tests; Trehalose	1996
Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo. Cardiovascular research, 1996, Volume: 31, Issue:5 Topics: Acetylcholine; Acetylcysteine; Animals; Arginine; Drug Tolerance; Female; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Rats; Rats, Wistar; Vasodilation	1996
N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction: safety and biochemical effects. Circulation, 1996, Oct-01, Volume: 94, Issue:7 Topics: Acetylcysteine; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; Humans; Myocardial Infarction; Nitroglycerin; Streptokinase; Vasodilator Agents	1996
N-Acetylcysteine potentiates nitroglycerin-induced reversal of platelet aggregation. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:3 Topics: Acetylcysteine; Adult; Aged; Angina Pectoris; Aspirin; Blood Platelets; Drug Synergism; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Nitroglycerin; Platelet Aggregation Inhibitors	1996
Studies of vascular tolerance to nitroglycerin: effects of N-acetylcysteine, NG-monomethyl L-arginine, and endothelin-1. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:3 Topics: Acetylcysteine; Animals; Aorta; Cyclic GMP; Drug Tolerance; Endothelin-1; Enzyme Inhibitors; Free Radical Scavengers; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Rats; Vasodilator Agents	1996
N-acetylcysteine does not influence the activity of endothelium-derived relaxing factor in vivo. Hypertension (Dallas, Tex. : 1979), 1997, Volume: 29, Issue:2 Topics: Acetylcysteine; Adult; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Humans; Injections, Intra-Arterial; Male; Methacholine Chloride; Middle Aged; Nitric Oxide; Nitroglycerin; omega-N-Methylarginine	1997
Diverse relaxation responses of canine large and small conductive coronary arteries to glyceryl trinitrate and nitric oxide on the one hand and to 8-bromoguanosine 3':5' cyclic monophosphate on the other. Japanese journal of pharmacology, 1998, Volume: 76, Issue:1 Topics: Acetylcysteine; Animals; Biotransformation; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cysteine; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Female; Free Radical Scavengers; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Vasodilation; Vasodilator Agents	1998
Effects of N-acetylcysteine on nitroglycerin-induced relaxation and protein phosphorylation of porcine coronary arteries. Heart and vessels, 1998, Volume: 13, Issue:6 Topics: Acetylcysteine; Animals; Coronary Vessels; Desmin; Drug Synergism; Drug Tolerance; Muscle, Smooth, Vascular; Myosin Light Chains; Nitroglycerin; Phosphorylation; Swine; Vasodilator Agents	1998
Comparison of zofenopril and lisinopril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE-inhibitors in experimental heart failure. British journal of pharmacology, 2000, Volume: 130, Issue:8 Topics: Acetylcholine; Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Calcimycin; Captopril; Endothelium, Vascular; Heart Diseases; In Vitro Techniques; Lisinopril; Male; Myocardial Infarction; Nitrates; Nitrites; Nitroglycerin; omega-N-Methylarginine; Rats; Rats, Wistar; Sodium Nitrite; Sulfhydryl Compounds; Vasodilation; Vasodilator Agents	2000
Depletion of intracellular glutathione reduces mutations by nitric oxide-donating drugs. Nitric oxide : biology and chemistry, 2000, Volume: 4, Issue:5 Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Survival; Gamma Rays; Glutathione; Hypoxanthine Phosphoribosyltransferase; Mice; Mutagenesis; Mutagens; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroglycerin; Nitroprusside; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured	2000
N-acetylcysteine improves coronary and peripheral vascular function. Journal of the American College of Cardiology, 2001, Volume: 37, Issue:1 Topics: Acetylcysteine; Adult; Coronary Artery Disease; Coronary Circulation; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Female; Femoral Artery; Humans; Infusions, Intravenous; Male; Middle Aged; Nitric Oxide; Nitroglycerin; Nitroprusside; Vasodilation	2001
Reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril: a role of calcitonin gene-related peptide. European journal of pharmacology, 2002, Mar-29, Volume: 439, Issue:1-3 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Pressure; Calcitonin Gene-Related Peptide; Captopril; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Rats; Rats, Wistar; Vasodilation	2002
Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects. Thrombosis research, 2003, Apr-15, Volume: 110, Issue:1 Topics: Acetylcysteine; Adenosine Diphosphate; Adult; Amifostine; Antioxidants; Collagen; Cyclic GMP; Drug Resistance; Female; Free Radical Scavengers; Humans; Insulin Resistance; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Obesity; Platelet Aggregation; Platelet Aggregation Inhibitors; Superoxide Dismutase	2003
Formation of releasable NO stores by S-nitrosoglutathione in arteries exhibiting tolerance to glyceryl-trinitrate. European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2 Topics: Acetylcysteine; Analysis of Variance; Animals; Aorta, Thoracic; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Nitric Oxide; Nitrogen Oxides; Nitroglycerin; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thionucleotides; Vasoconstriction; Vasodilation	2005
Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. European journal of pharmacology, 2007, Sep-24, Volume: 571, Issue:1 Topics: Acetylcysteine; Aldehyde Dehydrogenase; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Calcitonin Gene-Related Peptide; Captopril; Cell Line; Chloral Hydrate; Cyanamide; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Endothelial Cells; Humans; In Vitro Techniques; Male; Nitric Oxide Donors; Nitroglycerin; Rats; Rats, Wistar; Reactive Oxygen Species; Vasodilation	2007
Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2. Life sciences, 2008, Mar-26, Volume: 82, Issue:13-14 Topics: Acetylcysteine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Amidohydrolases; Arginine; Cell Line; Cyclic GMP; Drug Tolerance; Endothelial Cells; Humans; Lipid Peroxides; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroglycerin; Oxidative Stress; Reactive Oxygen Species	2008
Significant improvement in islet yield and survival with modified ET-Kyoto solution: ET-Kyoto/Neutrophil elastase inhibitor. Cell transplantation, 2013, Volume: 22, Issue:1 Topics: Acetylcysteine; Animals; Apoptosis; Bucladesine; Cell Survival; Gluconates; Hydroxyethyl Starch Derivatives; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred C57BL; Nitroglycerin; Proteinase Inhibitory Proteins, Secretory; Random Allocation; Trehalose	2013
Comparison Between Modified Extracellular-Type Trehalose-Containing Kyoto Solution and University of Wisconsin Solution in 18-Hour Pancreas Preservation for Islet Transplantation. Pancreas, 2018, Volume: 47, Issue:7 Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Blood Glucose; Bucladesine; Diabetes Mellitus, Experimental; Female; Gluconates; Glutathione; Hydroxyethyl Starch Derivatives; Insulin; Islets of Langerhans Transplantation; Mice, Nude; Nitroglycerin; Organ Preservation; Organ Preservation Solutions; Pancreas; Raffinose; Reproducibility of Results; Swine; Transplantation, Heterologous; Trehalose	2018