Compounds > acetylcysteine

acetylcysteine and nitrates

acetylcysteine has been researched along with nitrates in 70 studies

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-19907 (10.00)18.7374
1990's19 (27.14)18.2507
2000's24 (34.29)29.6817
2010's15 (21.43)24.3611
2020's5 (7.14)2.80

Authors

AuthorsStudies
Horowitz, JD1
Aldershvile, J; Boesgaard, S; Grande, P; Madsen, JK; Pedersen, F; Pietersen, A1
Henry, PJ; Horowitz, JD; Louis, WJ1
Bassenge, E; Holtz, J; Mülsch, A; Münzel, T; Stewart, DJ1
Berkenboom, G; Bethume, P; Degré, S; Unger, P1
Noack, E; Schröder, H1
Chong, S; Fung, HL; Hough, K; Kakemi, M; Kowaluk, E1
Farrell, B; Lahey, KA; Parker, JO; Rose, BF1
Kaye, CM1
Di Bello, MG; Gambassi, F; Lupini, M; Mannaioni, PF; Masini, E; Mugnai, L; Pistelli, A; Raspanti, S1
De Wit, N; Gillet, R; Huyghens, L; Spapen, H; Zhang, H1
Aldershvile, J; Anderson, ME; Boesgaard, S; Loft, S; Meister, A; Poulsen, HE1
Derossi, D; Greene, LA; Prochiantz, A; Shelanski, ML; Troy, CM1
Abeles, AJ; Block, ER; Patel, JM1
Aldershvile, J; Boesgaard, S; Laursen, JB; Poulsen, HE1
Clark, JE; Foresti, R; Green, CJ; Motterlini, R1
Kondo, H; Niki, E; Takahashi, M1
Gow, AJ; Ischiropoulos, H; Thom, SR1
Anand, R; Fernando, B; Hamilton, G; Harry, D; Holt, S; Marley, R; Moore, K; Sanderson, P; Smith, R1
Caputi, AP; Costantino, G; Cuzzocrea, S1
Paine, AJ; Rodriguez-Ariza, A1
Frölich, JC; Rossa, S; Sandmann, J; Tsikas, D1
Clark, JE; Foresti, R; Green, CJ; Motterlini, R; Sarathchandra, P1
Caputi, AP; Costantino, G; Cuzzocrea, S; Mazzon, E1
Lin, KT; Wong, PY; Xue, JY1
Besner, JG; Bouchard, JF; Cabassi, A; de Champlain, J; Dumont, EC; Girouard, H; Lamontagne, D; Le Jossec, M2
Chen, Q; Gole, M; Gow, AJ; Ischiropoulos, H; Lee, VM; Themistocleous, M1
Ford, CA; Gadag, V; Longerich, L; Parai, S; Vasdev, S; Wadhawan, S1
Buikema, H; Crijns, HJ; de Zeeuw, D; Monnink, SH; Tio, RA; van Gilst, WH1
Caputi, AP; Costantino, G; Cuzzocrea, S; De Sarro, A; Mazzon, E; Serraino, I1
Caputi, AP; Centorrino, T; Ciccolo, A; Cuzzocrea, S; De Sarro, A; Dugo, L; Mazzon, E; Serraino, I1
Arregui, B; Conesa, EL; Fenoy, FJ; López, B; Nadal, JC; Salom, MG; Valero, F1
Bergamini, S; Daneri, F; Iannone, A; Rota, C; Tomasi, A; Virgili, F1
Blanchard, D; Girgenti, E; Mahy, JP; Ricoux, R; Sauriat-Dorizon, H1
Avlan, D; Cinel, I; Cinel, L; Dikmengil, M; Koksel, O; Okcu, H; Oral, U; Ozdulger, A; Unlu, A1
Halliwell, B; Hyun, DH; Jenner, P; Lee, M1
Aydin, A; Balkan, M; Buyukdogan, V; Gul, H; Onguru, O; Sen, D; Simsek, A; Yagci, G; Yildiz, O; Zeybek, N1
Atis, S; Bagdatoglu, O; Comelekoglu, U; Gunes, S; Nayci, A; Ozge, A1
Guo, Z; McNeill, JH; Nagareddy, PR; Xia, Z; Zhang, W1
Ippolito, S; Mani, AR; Moore, KP; Ollosson, R1
Abdalla, DS; Alves, VA; Carrilho, FJ; de Lima, VM; de Oliveira, CP; de Oliveira, MG; Laurindo, FR; Lopasso, FP; Simplicio, FI; Yuahasi, K1
MacLeod, KM; McNeill, JH; Nagareddy, PR; Xia, Z1
Kasielski, M; Luczynski, R; Nowak, D; Rysz, J; Sarniak, A; Stolarek, RA; Wlodarczyk, A1
Blasig, IE; Christen, S; Frese-Schaper, M; Mühlemann, MK; Schulthess, FT; Shaw, SG; Sury, MD; Täuber, MG1
Davidson, BR; Glantzounis, GK; Knight, I; Rocks, SA; Salacinski, HJ; Seifalian, AM; Sheth, H; Winyard, PG1
Birdane, YO; Buyukokuroglu, ME; Cemek, M; Yavuz, Y; Yurumez, Y1
Celedón, G; González, G; Lissi, EA; Pino, J1
Tchounwou, PB; Yedjou, CG1
Dias, AS; Garcia, E; Marroni, CA; Marroni, NP; Meurer, L; Picada, JN; Tieppo, J; Vercelino, R1
Björnsson, B; Bojmar, L; Gullstrand, P; Sandström, P; Sundqvist, T; Trulsson, L; Winbladh, A1
Jo, YH; Kim, K; Kwon, WY; Lee, JH; Rhee, JE; Rim, KP; Suh, GJ1
Blackwell, JR; Damsgaard, R; Hellsten, Y; Jones, AM; Mortensen, SP; Nyberg, M1
Abdelmegeed, MA; Banerjee, A; Hardwick, JP; Jang, S; Song, BJ1
Akyol, A; Besler, HT; Buyuktuncer, Z; Kuyumcu, A; Ozmen, MM1
de Oliveira, MG; de Souza, GF; Taladriz-Blanco, P; Velloso, LA1
Brooks, AD; Ercan, UK; Ji, HF; Joshi, SG; Smith, J1
Arstall, M; Beltrame, JF; Du, YT; Grover, S; Heresztyn, T; Holmes, A; Horowitz, JD; Mahadavan, G; Pasupathy, S; Procter, NEK; Raman, B; Selvanayagam, J; Stafford, I; Tavella, R; Zeitz, C1
Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F1
Boyle, AJ; Khan, AA1
Auffret, V; Le Breton, H; Mansour, A1
Li, L; Su, Q; Ye, Z1
Beltrame, JF; Pasupathy, S; Tavella, R1
Chang, YL; Chen, CH; Chen, CJ; Chen, WY; Chian, CY; Ho, YC; Huang-Liu, R; Kuan, YH; Lee, CY; Lee, SS; Lin, ML; Su, CH; Tsai, PK; Yang, ML1
Coitinho, AS; de Coelho, DM; Deon, M; Guerreiro, GB; Jacques, CE; Jardim, LB; Marchetti, DP; Mescka, CP; Moura, DJ; Poletto, F; Steffens, L; Vargas, CR; Viario, AG1
Tsikas, D1
Lee, H; Li, Y; Song, K; Tang, T1
Cumaoğlu, B; Günay, N; Oğuz Cumaoğlu, M; Tekin, Y1
Hwan Shin, D; Jie, G; Kang, JH; Kim, DW; Kim, JY; Kim, S; Kim, YJ; Kwan Kwon, T; Na, SB; Oh, DW; Park, CW; Shin, MS; Sung Kang, K1
Black, M; Blackwell, J; Clark, I; Home, J; Jones, AM; Tan, R; Vanhatalo, A; Wylie, L1

Reviews

3 review(s) available for acetylcysteine and nitrates

ArticleYear
Role of nitrates in unstable angina pectoris.
    The American journal of cardiology, 1992, Sep-24, Volume: 70, Issue:8

    Topics: Acetylcysteine; Angina, Unstable; Drug Therapy, Combination; Humans; Nitrates; Nitroglycerin

1992
[Tolerance of nitrate derivatives: pharmacologic and clinical aspects].
    Revue medicale de Bruxelles, 1989, Volume: 10, Issue:3

    Topics: Acetylcysteine; Drug Tolerance; Humans; Muscle, Smooth, Vascular; Nitrates; Sulfhydryl Compounds

1989
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders].
    Nederlands tijdschrift voor geneeskunde, 1994, Apr-02, Volume: 138, Issue:14

    Topics: Acetaminophen; Acetylcysteine; Acquired Immunodeficiency Syndrome; Antioxidants; Chemical and Drug Induced Liver Injury; Humans; Myocardial Reperfusion Injury; Nitrates; Reactive Oxygen Species; Respiratory Distress Syndrome

1994

Trials

6 trial(s) available for acetylcysteine and nitrates

ArticleYear
Continuous oral N-acetylcysteine treatment and development of nitrate tolerance in patients with stable angina pectoris.
    Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:6

    Topics: Acetylcysteine; Administration, Oral; Aged; Angina Pectoris; Double-Blind Method; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nitrates; Time Factors

1991
Nitrate tolerance: the lack of effect of N-acetylcysteine.
    Circulation, 1987, Volume: 76, Issue:3

    Topics: Acetylcysteine; Administration, Oral; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Drug Tolerance; Exercise Test; Hemodynamics; Humans; Infusions, Intravenous; Isosorbide Dinitrate; Nitrates; Random Allocation; Time Factors

1987
Increased hydrogen peroxide concentration in the exhaled breath condensate of stable COPD patients after nebulized N-acetylcysteine.
    Pulmonary pharmacology & therapeutics, 2007, Volume: 20, Issue:3

    Topics: Acetylcysteine; Aged; Analysis of Variance; Breath Tests; Cross-Over Studies; Double-Blind Method; Exhalation; Expectorants; Expiratory Reserve Volume; Female; Forced Expiratory Flow Rates; Forced Expiratory Volume; Humans; Hydrogen Peroxide; Male; Middle Aged; Nebulizers and Vaporizers; Nitrates; Nitrites; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Sulfhydryl Compounds

2007
Lifelong physical activity prevents an age-related reduction in arterial and skeletal muscle nitric oxide bioavailability in humans.
    The Journal of physiology, 2012, Nov-01, Volume: 590, Issue:21

    Topics: Acetylcholine; Acetylcysteine; Adult; Aged; Aging; Antioxidants; Femoral Artery; Humans; Leg; Male; Middle Aged; Motor Activity; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitrites; Norepinephrine; Regional Blood Flow; Young Adult

2012
Improved oxidative status in major abdominal surgery patients after N-acetyl cystein supplementation.
    Nutrition journal, 2015, Jan-06, Volume: 14

    Topics: Abdomen; Acetylcysteine; Aged; Antioxidants; Colonic Neoplasms; Female; Glutathione; Humans; Male; Malondialdehyde; Middle Aged; Nitrates; Oxidative Stress; Pancreatic Neoplasms; Preoperative Care; Reactive Oxygen Species; Rectal Neoplasms; Stomach Neoplasms

2015
Early Use of N-acetylcysteine With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction Reduces Myocardial Infarct Size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Inf
    Circulation, 2017, Sep-05, Volume: 136, Issue:10

    Topics: Acetylcysteine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nitrates; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction; Treatment Outcome

2017

Other Studies

61 other study(ies) available for acetylcysteine and nitrates

ArticleYear
Determinants of in vitro nitroglycerin tolerance induction and reversal: influence of dose regimen, nitrate-free period, and sulfhydryl supplementation.
    Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcysteine; Animals; Cattle; Drug Tolerance; In Vitro Techniques; Muscle Relaxation; Nitrates; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Sulfhydryl Compounds

1989
Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist.
    Circulation, 1989, Volume: 79, Issue:1

    Topics: Acetylcysteine; Animals; Coronary Vessels; Dogs; Drug Interactions; Drug Tolerance; Enzyme Activation; Female; Guanylate Cyclase; Male; Nitrates; Pericardium; Vasodilation; Veins

1989
[Thiol-dependent activation of guanylate cyclase by organic nitrates].
    Zeitschrift fur Kardiologie, 1986, Volume: 75 Suppl 3

    Topics: Acetylcysteine; Animals; Cysteine; Enzyme Activation; Glutathione; Guanylate Cyclase; In Vitro Techniques; Liver; Nitrates; Rats; Structure-Activity Relationship; Sulfhydryl Compounds

1986
Mechanisms for the pharmacologic interaction of organic nitrates with thiols. Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcysteine.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:2

    Topics: Acetylcysteine; Animals; Aorta; Blood Pressure; Glutathione; Humans; In Vitro Techniques; Male; Metabolic Clearance Rate; Muscle, Smooth, Vascular; Nitrates; Nitroglycerin; Rats; Rats, Inbred Strains; Serine; Vasodilation

1988
Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein.
    The Biochemical journal, 1973, Volume: 134, Issue:4

    Topics: Acetylcysteine; Acrolein; Alcohols; Aldehydes; Allyl Compounds; Animals; Bile; Chromatography, Paper; Esters; Formates; Injections, Subcutaneous; Male; Nitrates; Phosphates; Propionates; Rats; Sulfoxides; Sulfur Isotopes

1973
Generation of nitric oxide from nitrovasodilators modulates the release of histamine from mast cells.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1994, Volume: 45, Issue:1

    Topics: Acetylcysteine; Animals; Calcimycin; Cell Survival; Histamine Release; Male; Mast Cells; Nitrates; Nitric Oxide; Oxyhemoglobins; p-Methoxy-N-methylphenethylamine; Rats; Rats, Wistar; Vasodilator Agents

1994
Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels.
    Circulation research, 1994, Volume: 74, Issue:1

    Topics: Acetylcysteine; Animals; Arteries; Drug Tolerance; Female; Nitrates; Nitroglycerin; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Reference Values; Sulfhydryl Compounds; Thiazoles; Thiazolidines; Veins

1994
Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Volume: 16, Issue:1

    Topics: Acetylcysteine; Animals; Cell Death; Chelating Agents; Cyclic AMP; Down-Regulation; Free Radicals; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oligonucleotides, Antisense; PC12 Cells; Peptides; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Superoxide Dismutase

1996
Nitric oxide exposure and sulfhydryl modulation alter L-arginine transport in cultured pulmonary artery endothelial cells.
    Free radical biology & medicine, 1996, Volume: 20, Issue:5

    Topics: Acetylcysteine; Acrolein; Animals; Arginine; Biological Transport; Cells, Cultured; Dithiothreitol; Endothelium, Vascular; Ethylmaleimide; L-Lactate Dehydrogenase; Lipid Peroxidation; Nitrates; Nitric Oxide; Nitrites; Penicillamine; Pulmonary Artery; S-Nitroso-N-Acetylpenicillamine; Sulfhydryl Compounds; Swine

1996
Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo.
    Cardiovascular research, 1996, Volume: 31, Issue:5

    Topics: Acetylcholine; Acetylcysteine; Animals; Arginine; Drug Tolerance; Female; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Rats; Rats, Wistar; Vasodilation

1996
Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions.
    The Journal of biological chemistry, 1997, Jul-18, Volume: 272, Issue:29

    Topics: Acetylcysteine; Animals; Aorta; Buthionine Sulfoximine; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Glutathione; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Kinetics; Membrane Proteins; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sulfhydryl Compounds; Superoxides; Umbilical Veins

1997
Peroxynitrite-induced hemolysis of human erythrocytes and its inhibition by antioxidants.
    FEBS letters, 1997, Aug-18, Volume: 413, Issue:2

    Topics: Acetylcysteine; Albumins; Amidines; Antioxidants; Azoles; Catalase; Chromans; Erythrocytes; Glutathione; Hematocrit; Hemolysis; Humans; Isoindoles; Molsidomine; Nitrates; Organoselenium Compounds; Uric Acid; Vitamin E

1997
Nitric oxide and peroxynitrite-mediated pulmonary cell death.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Acetylcysteine; Animals; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Epithelial Cells; Kinetics; Lung; Male; Molsidomine; Nitrates; Nitric Oxide; Nitrogen Oxides; Oxidants; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Spermine

1998
N-acetylcysteine prevents development of the hyperdynamic circulation in the portal hypertensive rat.
    Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:3

    Topics: Acetylcysteine; Animals; Dinoprost; Hemodynamics; Hypertension, Portal; Male; Nitrates; Nitric Oxide; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

1998
Protective effect of N-acetylcysteine on cellular energy depletion in a non-septic shock model induced by zymosan in the rat.
    Shock (Augusta, Ga.), 1999, Volume: 11, Issue:2

    Topics: Acetylcysteine; Animals; Cell Membrane Permeability; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Macrophages, Peritoneal; Male; NAD; Nitrates; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sepsis; Shock; Tyrosine; Zymosan

1999
Rapid induction of NF-kappaB binding during liver cell isolation and culture: inhibition by L-NAME indicates a role for nitric oxide synthase.
    Biochemical and biophysical research communications, 1999, Apr-02, Volume: 257, Issue:1

    Topics: Acetylcysteine; Animals; Antioxidants; Binding, Competitive; Cell Culture Techniques; Cell Separation; Cell Survival; Cells, Cultured; Chromans; Dithiothreitol; Enzyme Inhibitors; Liver; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Oligonucleotides; Protein Binding; Rats; Rats, Sprague-Dawley; Response Elements; Time Factors

1999
High-performance liquid chromatographic analysis of nitrite and nitrate in human plasma as S-nitroso-N-acetylcysteine with ultraviolet absorbance detection.
    Journal of chromatography. B, Biomedical sciences and applications, 1999, Mar-05, Volume: 724, Issue:1

    Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Humans; Nitrates; Nitrites; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

1999
Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis.
    The Biochemical journal, 1999, May-01, Volume: 339 ( Pt 3)

    Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Apoptosis; Bilirubin; Cattle; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Induction; Free Radical Scavengers; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Metalloporphyrins; Nitrates; Protoporphyrins; Thiourea; Time Factors; Uric Acid

1999
Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat.
    Critical care medicine, 1999, Volume: 27, Issue:8

    Topics: Acetylcysteine; Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Free Radical Scavengers; Leukocyte Count; Male; Multiple Organ Failure; Nitrates; Nitric Oxide; Peritonitis; Random Allocation; Rats; Rats, Sprague-Dawley; Shock, Septic; Survival Analysis; Time Factors; Zymosan

1999
Mechanisms of peroxynitrite-induced apoptosis in HL-60 cells.
    Advances in experimental medicine and biology, 1999, Volume: 469

    Topics: Acetylcysteine; Acridines; Apoptosis; Caspase 3; Caspases; Catalase; DNA Fragmentation; Enzyme Activation; Free Radical Scavengers; HL-60 Cells; Humans; L-Lactate Dehydrogenase; Luminescent Measurements; Nitrates; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Superoxides

1999
Effect of antioxidant treatments on nitrate tolerance development in normotensive and hypertensive rats.
    Journal of hypertension, 2000, Volume: 18, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Coronary Vessels; Drug Tolerance; Endothelium, Vascular; Hypertension; In Vitro Techniques; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Nitrates; Nitroprusside; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Vasodilation

2000
Two distinct mechanisms of nitric oxide-mediated neuronal cell death show thiol dependency.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:6

    Topics: Acetylcysteine; Animals; Cell Death; Cell Differentiation; Cell Line; Cell Survival; Cyclic GMP; Hydrazines; Molsidomine; Necrosis; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxidants; Sulfhydryl Compounds

2000
Aldehyde induced hypertension in rats: prevention by N-acetyl cysteine.
    Artery, 1998, Volume: 23, Issue:1

    Topics: Acetylcysteine; Aldehydes; Animals; Arterioles; Blood Platelets; Blood Pressure; Body Weight; Calcium; Carbohydrate Metabolism; Diet; Drinking; Eating; Energy Intake; Hyperplasia; Hypertension; Insulin Resistance; Kidney; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Organ Size; Pyruvaldehyde; Rats; Rats, Inbred WKY; Renal Artery; Viscera

1998
Comparison of zofenopril and lisinopril to study the role of the sulfhydryl-group in improvement of endothelial dysfunction with ACE-inhibitors in experimental heart failure.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: Acetylcholine; Acetylcysteine; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Calcimycin; Captopril; Endothelium, Vascular; Heart Diseases; In Vitro Techniques; Lisinopril; Male; Myocardial Infarction; Nitrates; Nitrites; Nitroglycerin; omega-N-Methylarginine; Rats; Rats, Wistar; Sodium Nitrite; Sulfhydryl Compounds; Vasodilation; Vasodilator Agents

2000
Effects of n-acetylcysteine in a rat model of ischemia and reperfusion injury.
    Cardiovascular research, 2000, Aug-18, Volume: 47, Issue:3

    Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Aorta; Fluorescent Antibody Technique, Indirect; Free Radical Scavengers; Ileum; In Vitro Techniques; Intercellular Adhesion Molecule-1; Leukocyte Count; Lipid Peroxidation; Male; Malondialdehyde; Nitrates; Nitrites; P-Selectin; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Splenic Artery; Tyrosine; Vasodilation

2000
Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:7

    Topics: Acetylcysteine; Animals; Blotting, Western; Carrageenan; Disease Models, Animal; DNA Damage; DNA-Binding Proteins; Erythrocytes; Free Radical Scavengers; I-kappa B Proteins; Immunohistochemistry; Intercellular Adhesion Molecule-1; Lung; Macrophages; Male; Malondialdehyde; Neutrophils; NF-KappaB Inhibitor alpha; Nitrates; Nitric Oxide; P-Selectin; Peroxidase; Pleurisy; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Tyrosine

2001
Effects of chronic N-acetylcysteine treatment on the actions of peroxynitrite on aortic vascular reactivity in hypertensive rats.
    Journal of hypertension, 2001, Volume: 19, Issue:7

    Topics: Acetylcholine; Acetylcysteine; Animals; Aorta; Drug Synergism; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Hypertension; In Vitro Techniques; Isoproterenol; Male; Malondialdehyde; Nitrates; Nitroprusside; Peroxynitrous Acid; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Tyrosine; Vasodilation; Vasodilator Agents; Vasomotor System

2001
N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 281, Issue:3

    Topics: Acetylcysteine; Acute Kidney Injury; Animals; Blood Flow Velocity; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Glomerular Filtration Rate; Kidney Medulla; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Rats; Rats, Wistar; Regional Blood Flow; Reperfusion; Reperfusion Injury; Vena Cava, Inferior

2001
N-Acetylcysteine negatively modulates nitric oxide production in endotoxin-treated rats through inhibition of NF-kappaB activation.
    Antioxidants & redox signaling, 2002, Volume: 4, Issue:1

    Topics: Acetylcysteine; Animals; Citrulline; DNA; Endotoxins; Enzyme Activation; Free Radical Scavengers; Lipopolysaccharides; Male; NF-kappa B; Nitrates; Nitric Oxide; Nitrites; Protein Binding; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha

2002
Regioselective nitration of phenol induced by catalytic antibodies.
    Journal of protein chemistry, 2002, Volume: 21, Issue:7

    Topics: Acetylcysteine; Animals; Antibodies, Catalytic; Antibodies, Monoclonal; Catalysis; Cyanides; Enzyme Inhibitors; Female; Free Radical Scavengers; Free Radicals; Glutathione; Horses; Hydrogen Peroxide; Iron; Kinetics; Mice; Mice, Inbred BALB C; Nitrates; Peroxidases; Phenol; Sodium Nitrite; Stereoisomerism

2002
The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model.
    Shock (Augusta, Ga.), 2003, Volume: 19, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Cecum; Disease Models, Animal; Intestinal Perforation; Ligation; Lipid Peroxidation; Lung; Lung Diseases; Male; Malondialdehyde; Nitrates; Nitrites; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Resuscitation; Systemic Inflammatory Response Syndrome

2003
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins.
    Journal of neurochemistry, 2003, Volume: 86, Issue:2

    Topics: Acetylcysteine; alpha-Synuclein; Cell Line; Cell Survival; Cysteine Endopeptidases; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Ligases; Macromolecular Substances; Multienzyme Complexes; Nerve Tissue Proteins; Neurofilament Proteins; Nitrates; Nitric Oxide Synthase; Proteasome Endopeptidase Complex; Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tubulin; Ubiquitin; Ubiquitin-Protein Ligases

2003
Beneficial effects of N-acetylcysteine on sodium taurocholate-induced pancreatitis in rats.
    Journal of gastroenterology, 2004, Volume: 39, Issue:3

    Topics: Acetylcysteine; Acute Disease; Amylases; Animals; Antioxidants; Cholagogues and Choleretics; Glutathione Peroxidase; Lipase; Male; Malondialdehyde; Nitrates; Nitrites; Pancreatitis; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Taurocholic Acid; Time Factors

2004
N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis.
    Shock (Augusta, Ga.), 2006, Volume: 25, Issue:1

    Topics: Acetylcysteine; Animals; Catalase; Electromyography; Malondialdehyde; Nitrates; Nitrites; Oxidation-Reduction; Oxidative Stress; Peroxidase; Phrenic Nerve; Rats; Rats, Wistar; Sepsis

2006
Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats.
    Free radical research, 2006, Volume: 40, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Arteries; Blood Pressure; Diabetes Mellitus, Experimental; Dinoprost; Free Radicals; Heart Rate; Lipid Peroxidation; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Rats; Rats, Wistar; Streptozocin; Vasoconstrictor Agents

2006
Nitration of cardiac proteins is associated with abnormal cardiac chronotropic responses in rats with biliary cirrhosis.
    Hepatology (Baltimore, Md.), 2006, Volume: 43, Issue:4

    Topics: Acetylcysteine; Animals; Enzyme Inhibitors; Heart Rate; Immunohistochemistry; Liver Cirrhosis, Biliary; Male; Microscopy, Electron; Muscle Proteins; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Osmolar Concentration; Phenylethyl Alcohol; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Tyrosine

2006
Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats.
    World journal of gastroenterology, 2006, Mar-28, Volume: 12, Issue:12

    Topics: Acetylcysteine; Administration, Oral; Animals; Disease Models, Animal; Fatty Liver; Lipid Peroxidation; Liver; Male; Necrosis; Nitrates; Rats; Rats, Wistar; Transaminases

2006
N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:4

    Topics: Acetylcysteine; Animals; Blood Glucose; Blood Pressure; Blotting, Western; Cholesterol; Diabetes Mellitus, Experimental; Free Radical Scavengers; Heart Rate; Immunohistochemistry; Insulin; Isoprostanes; Male; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Stress, Physiological; Triglycerides; Tyrosine

2006
Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase.
    Free radical biology & medicine, 2006, Nov-01, Volume: 41, Issue:9

    Topics: Acetylcysteine; Animals; Brain; Cell Line; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; MAP Kinase Signaling System; NF-kappa B; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Phosphorylation; Protein Transport; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Tumor Necrosis Factor-alpha; Up-Regulation

2006
Formation and role of plasma S-nitrosothiols in liver ischemia-reperfusion injury.
    Free radical biology & medicine, 2007, Mar-15, Volume: 42, Issue:6

    Topics: Acetylcysteine; Animals; Electron Spin Resonance Spectroscopy; Electron Transport Complex IV; Electrophoresis, Capillary; Liver; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Rabbits; Reactive Nitrogen Species; Reperfusion Injury; RNA, Messenger; S-Nitrosothiols

2007
Beneficial effect of N-acetylcysteine against organophosphate toxicity in mice.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3

    Topics: Acetylcysteine; Animals; Atropine; Cholinesterase Inhibitors; Drug Therapy, Combination; Fenthion; Free Radical Scavengers; Glutathione; Injections, Intraperitoneal; Injections, Subcutaneous; Insecticides; Kaplan-Meier Estimate; Male; Malondialdehyde; Mice; Nitrates; Nitrites; Oxidative Stress; Time Factors

2007
Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity.
    Free radical research, 2007, Volume: 41, Issue:3

    Topics: Acetylcysteine; Anion Exchange Protein 1, Erythrocyte; Anions; Catechin; Erythrocytes; Hemoglobins; Humans; Ion Transport; Nitrates; Oxidants; Oxidation-Reduction; Peroxynitrous Acid; Tyrosine

2007
N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells.
    International journal of environmental research and public health, 2007, Volume: 4, Issue:2

    Topics: Acetylcysteine; Cell Proliferation; Cell Survival; Chelating Agents; Free Radicals; Humans; Lead; Lipid Peroxidation; Liver Neoplasms; Mutation; Nitrates; Oxidative Stress; Thiobarbiturates

2007
N-acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome.
    Basic & clinical pharmacology & toxicology, 2008, Volume: 102, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Comet Assay; Common Bile Duct; DNA Damage; Hepatopulmonary Syndrome; Ligation; Lipid Peroxidation; Liver; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Lung; Male; Micronuclei, Chromosome-Defective; Micronucleus Tests; Nitrates; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors

2008
N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs.
    Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:2

    Topics: Acetylcysteine; Adenosine Triphosphate; Analysis of Variance; Animals; Apoptosis; Aspartate Aminotransferases; Free Radical Scavengers; Glutathione; Glycogen; Lactic Acid; Leukocyte Count; Liver; Male; Microdialysis; Neutrophils; Nitrates; Nitrites; Reperfusion Injury; Swine

2012
Effect of N-acetylcysteine (NAC) on acute lung injury and acute kidney injury in hemorrhagic shock.
    Resuscitation, 2013, Volume: 84, Issue:1

    Topics: Acetylcysteine; Acute Kidney Injury; Acute Lung Injury; Animals; Arterial Pressure; Glucose; I-kappa B Proteins; Interleukin-6; Male; Malondialdehyde; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrates; Nitrites; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic

2013
Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury.
    Free radical biology & medicine, 2013, Volume: 60

    Topics: Acetaminophen; Acetanilides; Acetylcysteine; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Mice; Mitochondria, Liver; Nitrates; Oxidative Stress; Proteins; Superoxide Dismutase

2013
Nitric oxide released from luminal s-nitroso-N-acetylcysteine increases gastric mucosal blood flow.
    Molecules (Basel, Switzerland), 2015, Mar-04, Volume: 20, Issue:3

    Topics: Acetylcysteine; Animals; Gastric Mucosa; Laser-Doppler Flowmetry; Luminescent Measurements; Male; Nitrates; Nitric Oxide; Nitrogen; Rats; Rats, Sprague-Dawley; Regional Blood Flow

2015
Chemical Changes in Nonthermal Plasma-Treated N-Acetylcysteine (NAC) Solution and Their Contribution to Bacterial Inactivation.
    Scientific reports, 2016, Feb-02, Volume: 6

    Topics: Acetylcysteine; Anti-Bacterial Agents; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Microbial Viability; Nitrates; Nitrites; Pharmaceutical Solutions; Plasma Gases; Reactive Nitrogen Species; Reactive Oxygen Species; Spectroscopy, Fourier Transform Infrared

2016
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:2

    Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-6; Ischemia; Lactic Acid; Male; Muscle, Skeletal; Nitrates; Nitrites; Oxidative Stress; Oxygen; Oxygen Consumption; Peroxidase; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Vascular Endothelial Growth Factor A

2018
Letter by Khan and Boyle Regarding Article, "Early Use of N-Acetylcysteine (NAC) With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Reduces Myocardial Infarct Size (The NAC
    Circulation, 2018, 03-27, Volume: 137, Issue:13

    Topics: Acetylcysteine; Humans; Myocardial Infarction; Nitrates; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction

2018
Letter by Mansour et al Regarding Article, "Early Use of N-Acetylcysteine With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction Reduces Myocardial Infarct Size (the NACIAM Tri
    Circulation, 2018, 03-27, Volume: 137, Issue:13

    Topics: Acetylcysteine; Humans; Myocardial Infarction; Nitrates; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction

2018
Letter by Ye et al Regarding Article, "Early Use of
    Circulation, 2018, 03-27, Volume: 137, Issue:13

    Topics: Acetylcysteine; Humans; Myocardial Infarction; Nitrates; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction

2018
Response by Pasupathy et al to Letters Regarding Article, "Early Use of N-acetylcysteine (NAC) With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction Reduces Myocardial Infarct
    Circulation, 2018, 03-27, Volume: 137, Issue:13

    Topics: Acetylcysteine; Humans; Myocardial Infarction; Nitrates; Percutaneous Coronary Intervention; ST Elevation Myocardial Infarction

2018
Cadmium nitrate-induced neuronal apoptosis is protected by N-acetyl-l-cysteine via reducing reactive oxygen species generation and mitochondria dysfunction.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 108

    Topics: Acetylcysteine; Animals; Apoptosis; Cadmium Compounds; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Membrane Potential, Mitochondrial; Mice; Mitochondria; Necrosis; Neurons; Nitrates; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction

2018
Oxidative Imbalance, Nitrative Stress, and Inflammation in C6 Glial Cells Exposed to Hexacosanoic Acid: Protective Effect of N-acetyl-L-cysteine, Trolox, and Rosuvastatin.
    Cellular and molecular neurobiology, 2018, Volume: 38, Issue:8

    Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Cell Survival; Chromans; Cytoplasmic Vesicles; DNA Damage; Fatty Acids; Inflammation; Interleukin-1beta; Isoprostanes; Neuroglia; Neuroprotective Agents; Nitrates; Nitrites; Nitrosative Stress; Oxidative Stress; Rats; Rosuvastatin Calcium

2018
GC-MS approach revealing hidden nitrite reactions in hemolysate using
    Analytical biochemistry, 2021, 01-15, Volume: 613

    Topics: Acetylcysteine; Cysteine; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Nitrates; Nitrites; Oxygen Isotopes; Sulfhydryl Compounds

2021
Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate.
    International journal of molecular sciences, 2021, May-24, Volume: 22, Issue:11

    Topics: Acetylcysteine; Aluminum; Antineoplastic Agents; Atmospheric Pressure; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Free Radicals; Humans; Hydrogen Peroxide; Liver Neoplasms; Neoplastic Stem Cells; Nitrates; Nitric Oxide; Nitrites; Plasma Gases; Reactive Nitrogen Species; Reactive Oxygen Species; Singlet Oxygen

2021
Therapeutic effect of 6-shogaol on acetaminophen-induced hepatotoxicity in mice: an experimental study.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:20

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Liver Diseases; Mice; Nitrates; Nitrites

2022
Preparation of inhalable N-acetylcysteine-loaded magnetite chitosan microparticles for nitrate adsorption in particulate matter.
    International journal of pharmaceutics, 2023, Jan-05, Volume: 630

    Topics: Acetylcysteine; Adsorption; Air Pollutants; Chitosan; Ferrosoferric Oxide; Nitrates; Particulate Matter

2023
Physiological and performance effects of dietary nitrate and N-acetylcysteine supplementation during prolonged heavy-intensity cycling.
    Journal of sports sciences, 2022, Volume: 40, Issue:23

    Topics: Acetylcysteine; Adult; Antioxidants; Cross-Over Studies; Dietary Supplements; Endurance Training; Exercise; Fruit and Vegetable Juices; Humans; Male; Nitrates; Nitrites; Oxygen Consumption; Plant Extracts; Plant Roots; Reactive Oxygen Species

2022