acetylcysteine has been researched along with n-acetyl-4-benzoquinoneimine in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Boobis, AR; Davies, DS; Fawthrop, DJ; Nasseri-Sina, P; Wilson, J | 1 |
| Maldonado, AL; Mitchell, MC; Speeg, KV | 1 |
| Kirsch, RE; Pillans, P; Robson, SC; Spearman, CW | 1 |
| Shichi, H; Zhao, C | 1 |
| Chua, SS; Huang, W; Moore, DD; Wei, P; Zhang, J | 1 |
| Commandeur, JN; Damsten, MC; Fidder, A; Hulst, AG; Noort, D; Touw, D; Vermeulen, NP | 1 |
| Capparelli, E; Davern, TJ; Hinson, JA; James, LP; Lee, WM; Letzig, L; Roberts, DW; Simpson, PM | 1 |
| Andersen, ME; Clewell, HJ; Harrill, AH; Howell, BA; Siler, SQ; Watkins, PB; Woodhead, JL; Yang, Y | 1 |
| Ejiri, Y; Kotake, Y; Ohta, S; Ohtsuki, Y; Sanoh, S; Santoh, M | 1 |
| Blomgren, A; Grundemar, L; Högestätt, ED; Nilsson, JLÅ; Nilsson, UJ | 1 |
| Kubo, T; Lee, SH; Oe, T; Ozawa, M | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; James, LP; McArdle, K; Pickering, JW | 1 |
| Bathaie, SZ; Hashemi, SA; Kyani, A | 1 |
| Chen, Y; Ge, W; Song, W; Yan, R | 1 |
| Buckley, NA; Chan, BSH; Chiew, AL; Isbister, GK; Isoardi, KZ; Page, C; Ress, K; Stathakis, P | 1 |
1 trial(s) available for acetylcysteine and n-acetyl-4-benzoquinoneimine
| Article | Year |
|---|---|
Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Topics: Acetaminophen; Acetylcysteine; Administration, Intravenous; Adolescent; Adult; Alanine Transaminase; Analgesics, Non-Narcotic; Australia; Benzoquinones; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Overdose; Female; Humans; Imines; Liver; Male; Middle Aged; Prospective Studies; Treatment Outcome; Young Adult | 2020 |
14 other study(ies) available for acetylcysteine and n-acetyl-4-benzoquinoneimine
| Article | Year |
|---|---|
Cytoprotection by iloprost against paracetamol-induced toxicity in hamster isolated hepatocytes.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cell Survival; Cricetinae; Glutathione; Iloprost; Imines; In Vitro Techniques; L-Lactate Dehydrogenase; Liver; Male; Mesocricetus; Prostaglandin Antagonists; Prostaglandins | 1992 |
Additive protection of cimetidine and N-acetylcysteine treatment against acetaminophen-induced hepatic necrosis in the rat.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cimetidine; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Imines; Liver; Male; Necrosis; Rats; Rats, Inbred F344 | 1985 |
Paracetamol poisoning.
Topics: Acetaminophen; Acetylcysteine; Benzoquinones; Chemical and Drug Induced Liver Injury; Clinical Protocols; Drug Overdose; Humans; Imines | 1993 |
Prevention of acetaminophen-induced cataract by a combination of diallyl disulfide and N-acetylcysteine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Allyl Compounds; Animals; Antimutagenic Agents; Benzoquinones; Cataract; Ciliary Body; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Disulfides; Drug Therapy, Combination; Garlic; Glutathione; Imines; Lens, Crystalline; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Plants, Medicinal | 1998 |
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Androstanols; Animals; Aryl Hydrocarbon Hydroxylases; Benzoquinones; Constitutive Androstane Receptor; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Imines; Isoenzymes; Liver; Mice; Mice, Knockout; Mice, Transgenic; Oxidoreductases, N-Demethylating; Phenobarbital; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors | 2002 |
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chromatography, Liquid; Cysteine; Humans; Imines; Microsomes, Liver; Models, Biological; Molecular Structure; Oligopeptides; Protein Binding; Rats; Reproducibility of Results; Serum Albumin; Tandem Mass Spectrometry | 2007 |
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Bayes Theorem; Benzoquinones; Biomarkers; Biotransformation; Databases as Topic; Drug Overdose; Female; Half-Life; Humans; Imines; Liver Failure, Acute; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nonlinear Dynamics; Young Adult | 2009 |
An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Alanine Transaminase; Benzoquinones; Chemical and Drug Induced Liver Injury; Cohort Studies; Computer Simulation; Hepatocytes; Humans; Imines; Infusions, Intravenous; Liver; Prescription Drug Misuse; Risk Factors | 2012 |
Acetaminophen analog N-acetyl-m-aminophenol, but not its reactive metabolite, N-acetyl-p-benzoquinone imine induces CYP3A activity via inhibition of protein degradation.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Gene Expression Regulation; Glutathione; Hepatocytes; Imines; Male; Primary Cell Culture; Protein Stability; Proteolysis; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2017 |
N,N'-Bis(2-mercaptoethyl)isophthalamide Binds Electrophilic Paracetamol Metabolites and Prevents Paracetamol-Induced Liver Toxicity.
Topics: Acetaminophen; Acetylcysteine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antidotes; Benzene Derivatives; Benzoquinones; Chelating Agents; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Imines; Mice; Sulfhydryl Compounds | 2018 |
LC-MS analyses of N-acetyl-p-benzoquinone imine-adducts of glutathione, cysteine, N-acetylcysteine, and albumin in a plasma sample: A case study from a patient with a rare acetaminophen-induced acute swelling rash.
Topics: Acetaminophen; Acetylcysteine; Acute Disease; Adult; Benzoquinones; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cysteine; Edema; Exanthema; Glutathione; Humans; Imines; Male; Protein Binding; Serum Albumin; Skin Diseases; Tandem Mass Spectrometry | 2019 |
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Topics: Acetaminophen; Acetylcysteine; Benzoquinones; COVID-19 Drug Treatment; Humans; Hydrogen; Imines; Vitamin K; Vitamin K Epoxide Reductases | 2022 |
Metabolic Competency of Larval Zebrafish in Drug-Induced Liver Injury: A Case Study of Acetaminophen Poisoning.
Topics: Acetaminophen; Acetylcysteine; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Glutathione; Imines; Larva; Liver; Mammals; Sulfates; Zebrafish | 2022 |
Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM-7).
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Australia; Chemical and Drug Induced Liver Injury; Drug Overdose; Humans; Liver; Retrospective Studies | 2023 |