acetylcysteine has been researched along with methotrexate in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 10 (37.04) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Berenbaum, MC | 1 |
| Kline, I | 1 |
| Lei, S; Ogiso, Y; Omura, S; Tomida, A; Tsuruo, T | 1 |
| Courteau, J; Kocsis-Bédard, S; Niyonsenga, T; Paquette, B; Thibodeau, PA | 1 |
| Desaki, M; Kawasaki, S; Kohyama, T; Okazaki, H; Takizawa, H; Yamamoto, K; Yamauchi, Y | 1 |
| Gao, F; Horie, T; Miyazono, Y | 1 |
| Deutsch, M; Herman, S; Zurgil, N | 1 |
| Bulbuloglu, E; Cetinkaya, A; Kantarceken, B; Kurutas, EB | 2 |
| Bulbuloglu, E; Celik, M; Cetinkaya, A; Ciralik, H; Kurutas, EB; Polat, A | 1 |
| Hamada, K; Horie, T; Ito, K; Maeda, T; Miyazono, Y; Sekine, S | 1 |
| Çağlar, Y; Gönlüşen, G; Matur, I; Özgür, H; Polat, S; Tuli, A; Yenilmez, ED | 1 |
| Akbulut, S; Dogan, Z; Elbe, H; Erdemli, E; Eris, C; Otan, E; Toprak, G; Turkoz, Y | 1 |
| Devaraja, S; Girish, KS; Hemshekhar, M; Kemparaju, K; Nagaraju, G; Naveen, S; NaveenKumar, SK; Nayaka, SC; Paul, M; Rangappa, KS; Somyajit, K; Sundaram, MS; Thushara, RM; West, R; Zakai, UI | 1 |
| Boris, SP; Popruzhenko, ТV | 1 |
| Bakr, AG; Khalifa, MMA; Osman, AT | 1 |
| Abedi, M; Esmaeili, A; Rahgozar, S | 1 |
| Abo-Youssef, AM; Hassan, MIA; Hemeida, RAM; Osman, AT; Sharkawi, SMZ | 1 |
| Aslanlar, DA; Nurullahoglu Atalik, KE; Oz, M; Vişneci, EF | 1 |
1 review(s) available for acetylcysteine and methotrexate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for acetylcysteine and methotrexate
| Article | Year |
|---|---|
[Salivation in children during anticancer chemotherapy].
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Child; Cross-Sectional Studies; Dose-Response Relationship, Drug; Expectorants; Humans; Leukemia; Methotrexate; Saliva; Salivation; Viscosity | 2016 |
25 other study(ies) available for acetylcysteine and methotrexate
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Direct search methods in the optimisation of cancer chemotherapy regimens.
Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Evaluation; Female; Ifosfamide; Leucovorin; Leukemia L1210; Methotrexate; Mice; Time Factors | 1990 |
Potentially useful combinations of chemotherapy detected in mouse tumor systems.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Azauridine; Bleomycin; Camptothecin; Cyclic P-Oxides; Cyclophosphamide; Cytarabine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethylamines; Fluorouracil; Imidazoles; Leukemia L1210; Lung Neoplasms; Methotrexate; Mice; Neoplasms, Experimental; Oxazines; Piperazines; Procarbazine; Propane; Triazenes | 1974 |
Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.
Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Northern; Cell Cycle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Glucose; Humans; Hypoxia; Immunoblotting; Isoenzymes; Methotrexate; Mice; Mice, Nude; Multienzyme Complexes; Neoplasm Transplantation; Nucleic Acid Synthesis Inhibitors; Proteasome Endopeptidase Complex; Time Factors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Vincristine | 2000 |
Thiols can either enhance or suppress DNA damage induction by catecholestrogens.
Topics: Acetylcysteine; Antioxidants; Copper; Dithiothreitol; DNA Damage; Drug Resistance, Neoplasm; Estradiol; Estrogens, Catechol; Glutathione; Hydrogen Peroxide; Kinetics; Methotrexate; NAD; Oxidation-Reduction; Reactive Oxygen Species; Sulfhydryl Compounds; Thioctic Acid | 2001 |
Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.
Topics: Acetylcysteine; Bronchi; Cell Line; Cycloheximide; Epithelial Cells; Folic Acid Antagonists; Free Radical Scavengers; Glucose; Humans; Hypoglycemia; Interleukin-1; Interleukin-8; Lipopolysaccharides; Methotrexate; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Pulmonary Alveoli; Threonine; Tumor Necrosis Factor-alpha; Tyrosine | 2004 |
Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Catalase; Intestinal Mucosa; Intestine, Small; Luminescent Measurements; Male; Methotrexate; Neutrophil Infiltration; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Tungsten Compounds; Xanthine Dehydrogenase | 2004 |
Low dose methotrexate induces apoptosis with reactive oxygen species involvement in T lymphocytic cell lines to a greater extent than in monocytic lines.
Topics: Acetylcysteine; Annexin A5; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Arthritis, Rheumatoid; Biological Assay; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Immunosuppressive Agents; Jurkat Cells; Leukocytes; Methotrexate; Monocytes; Oxidative Stress; Propidium; Reactive Oxygen Species; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Time Factors; U937 Cells | 2005 |
N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats.
Topics: Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Methotrexate; Oxidants; Oxidative Stress; Rats; Rats, Wistar | 2006 |
The effects of N-acetylcysteine on methotrexate-induced oxidative renal damage in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Glutathione; Humans; Kidney; Kidney Diseases; Methotrexate; Oxidants; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Wistar | 2007 |
Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Models, Animal; Oxidative Stress; Rats; Rats, Wistar | 2006 |
Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Body Weight; Dextrans; Fluorescein-5-isothiocyanate; Free Radical Scavengers; Glutathione; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Oxidative Stress; Permeability; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances; Time Factors | 2010 |
Ultrastructural evaluation of the effect of N-acetylcysteine on methotrexate nephrotoxicity in rats.
Topics: Acetylcysteine; Animals; Blood Urea Nitrogen; Creatinine; Glutathione Peroxidase; Immunohistochemistry; Ki-67 Antigen; Kidney; Kidney Glomerulus; Male; Malondialdehyde; Methotrexate; Rats; Rats, Wistar; Renal Insufficiency; Superoxide Dismutase | 2013 |
Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats.
Topics: Acetylcysteine; Amifostine; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Chemical and Drug Induced Liver Injury; Cytoprotection; Disease Models, Animal; Liver; Male; Methotrexate; Oxidative Stress; Rats, Sprague-Dawley; Time Factors | 2014 |
Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide.
Topics: Acetylcysteine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; BH3 Interacting Domain Death Agonist Protein; Blood Platelets; Gene Expression Regulation; Humans; MAP Kinase Kinase 4; Membrane Potential, Mitochondrial; Methotrexate; Mitochondria; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Primary Cell Culture; Signal Transduction | 2015 |
Protective effects of phloridzin against methotrexate-induced liver toxicity in rats.
Topics: Acetylcysteine; Animals; Biomarkers; Caspase 3; Inflammation; Liver; Male; Methotrexate; Oxidative Stress; Phlorhizin; Protective Agents; Rats; Survival Analysis | 2017 |
Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity.
Topics: Acetylcysteine; Bone Marrow; Cell Line, Tumor; Cell Survival; Child; Child, Preschool; Deferasirox; Drug Resistance, Neoplasm; Female; Ferric Compounds; Free Radical Scavengers; Humans; Infant; Inhibitory Concentration 50; Iron; Iron Chelating Agents; Male; Methotrexate; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-bcl-2; Quaternary Ammonium Compounds; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Transcriptome; Up-Regulation | 2020 |
Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats.
Topics: Acetylcysteine; Animals; Benzhydryl Compounds; Glucosides; Hesperidin; Inflammation; Kidney; Kidney Diseases; Male; Methotrexate; Oxidative Stress; Protective Agents; Rats; Signal Transduction | 2021 |
N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Antineoplastic Agents; Antioxidants; Anxiety; Brain-Derived Neurotrophic Factor; Cholinergic Agents; Depression; Humans; Inflammation; Male; Methotrexate; Oxidative Stress; Rats; Rats, Wistar | 2024 |