acetylcysteine and metformin

acetylcysteine has been researched along with metformin in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (27.78)	29.6817
2010's	21 (58.33)	24.3611
2020's	5 (13.89)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Funaki, B	1
Guven, GS; Kanigur, G; Onaran, I; Ozdaş, SB; Vehid, S	1
Elnashar, A; Fahmy, M; Ibrahim, K; Mansour, A	1
Barrett, B; Benko, A; Capusten, B; Fraser-Hill, M; Magner, P; Myers, A; Owen, RJ	1
De Vriese, AS; Van Praet, JT	1
Dhawan, A; Dziechciarz, P; Horvath, A; Socha, P; Szajewska, H; Vajro, P	1
Falbo, A; Palomba, S; Zullo, F	1
Abu Hashim, H; Anwar, K; El-Fatah, RA	1
Bershteĭn, LM; Boiarkina, MP; Kovalenko, IG; Kovalevskiĭ, AIu; Poroshina, TE; Revskoĭ, SIu; Vasil'ev, DA	1
Muderris, II; Oner, G	1
Bershteĭn, LM; Boiarkina, MP; Kisel'nikov, KS; Kovalenko, IG; Poroshina, TE; Vasil'ev, DA; Zaĭtsev, AN	1
Cacciapuoti, F	1
Grdina, DJ; Miller, RC; Murley, JS	1
Cheraghi, E; Ebrahimi, Z; Esfahani, MH; Mehranjani, MS; Shariatzadeh, MA	1
Azarpira, N; Bazyari, M; Heidari, R; Jamshidzadeh, A; Najibi, A; Niknahad, H	1
Abdelhafez, A; Bakry, A; Elsawah, H; Maged, AM; Mostafa, WA	1
Javanmanesh, F; Kashanian, M; Rahimi, M; Sheikhansari, N	1
Cheng, J; Hisatome, I; Hong, L; Hu, Y; Li, Z; Luo, C; Wen, T; Yamamoto, T; Yuan, H; Zhang, X; Zhang, Y; Zhu, Y; Zhuang, W; Zou, J	1
Grdina, DJ; Miller, RC; Murley, JS; Rademaker, AW; Senlik, RR	1
Donoviel, DB; Jones, JA; McLaughlin, MF	1
Heidari, B; Nemati, M; Nemati, S; Taheri, AM	1
Heng, TYJ; Mak, A; Tan, MKX	1
Cotrim, HP; Oliveira, CP; Parise, ER; Salgado, ALA; Siqueira, ACG; Stefano, JT	1
Huang, H; Song, Y; Wang, H; Zhu, Z	1
Chapman, C; Dludla, PV; Johnson, R; Kappo, AP; Louw, J; Mabasa, L; Mabhida, SE; Mosa, RA; Muller, CJF; Riedel, S; Sangweni, NF	1
Liu, H; Lu, X; Shi, Z; Zhang, P; Zhao, S; Zhu, B	1
Gryciuk, ME; Maciejczyk, M; Mil, KM; Pawlukianiec, C; Zalewska, A; Żendzian-Piotrowska, M; Ładny, JR	1
Hamid Reza Momeni, -; Matin Ramezani, -; Niloufar Darbandi, -; Samira Moghadasi, -	1
Abbas, HA; M Shafik, S; Saleh, MM; Yousef, N	1

Reviews

8 review(s) available for acetylcysteine and metformin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Prevention of contrast-induced nephropathy: a critical review. Current opinion in nephrology and hypertension, 2007, Volume: 16, Issue:4 Topics: Acetylcysteine; Acute Kidney Injury; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Contrast Media; Creatinine; Diuretics; Evidence-Based Medicine; Fluid Therapy; Humans; Mannitol; Metformin; Osmolar Concentration; Randomized Controlled Trials as Topic; Renal Replacement Therapy; Risk Factors; Theophylline; Viscosity	2007
Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. Journal of pediatric gastroenterology and nutrition, 2009, Volume: 48, Issue:5 Topics: Acetylcysteine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Carnitine; Child; Dietary Supplements; Drug Synergism; Drug Therapy, Combination; Fatty Liver; Humans; Hypoglycemic Agents; Liver; Metformin; Pioglitazone; Probucol; Randomized Controlled Trials as Topic; Thiazolidinediones; Ursodeoxycholic Acid; Vitamin E	2009
Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance. Current opinion in obstetrics & gynecology, 2009, Volume: 21, Issue:6 Topics: Acetylcysteine; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Bromocriptine; Clomiphene; Dexamethasone; Drug Resistance; Female; Fertility Agents, Female; Free Radical Scavengers; Glucocorticoids; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; Humans; Hypoglycemic Agents; Infertility, Female; Laparoscopy; Metformin; Naltrexone; Narcotic Antagonists; Octreotide; Ovary; Ovulation Induction; Polycystic Ovary Syndrome	2009
Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight. Aerospace medicine and human performance, 2017, Jul-01, Volume: 88, Issue:7 Topics: Acetylcysteine; Adrenergic beta-Antagonists; Aerospace Medicine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Astronauts; Calcium Channel Blockers; Fingolimod Hydrochloride; Free Radical Scavengers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Immunosuppressive Agents; Metformin; Pentoxifylline; Radiation Injuries; Radiation-Protective Agents; Space Flight	2017
The Potential Use of Metformin, Dipyridamole, N-Acetylcysteine and Statins as Adjunctive Therapy for Systemic Lupus Erythematosus. Cells, 2019, 04-06, Volume: 8, Issue:4 Topics: Acetylcysteine; Chemotherapy, Adjuvant; Dipyridamole; Drug Therapy, Combination; Humans; Lupus Erythematosus, Systemic; Metformin	2019
Comparison of the efficacy between NAC and metformin in treating PCOS patients: a meta-analysis. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2020, Volume: 36, Issue:3 Topics: Acetylcysteine; Body Mass Index; Female; Follicle Stimulating Hormone; Free Radical Scavengers; Humans; Hypoglycemic Agents; Insulin; Luteinizing Hormone; Metformin; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Testosterone; Treatment Outcome	2020
Pleiotropic Properties of Valsartan: Do They Result from the Antiglycooxidant Activity? Literature Review and Oxidative medicine and cellular longevity, 2021, Volume: 2021 Topics: Acetylcysteine; Animals; Antioxidants; Captopril; Chloramines; Chromans; Fructose; Glucose; Glycosylation; Humans; Metformin; Oxidation-Reduction; Pyruvaldehyde; Serum Albumin, Bovine; Thioctic Acid; Tosyl Compounds; Valsartan	2021

Trials

9 trial(s) available for acetylcysteine and metformin

Article	Year
N-acetyl cysteine vs. metformin in treatment of clomiphene citrate-resistant polycystic ovary syndrome: a prospective randomized controlled study. Fertility and sterility, 2007, Volume: 88, Issue:2 Topics: Acetylcysteine; Adolescent; Adult; Blood Glucose; Clomiphene; Drug Resistance; Female; Humans; Insulin; Metformin; Ovulation; Polycystic Ovary Syndrome; Selective Estrogen Receptor Modulators; Testosterone; Treatment Failure	2007
N-acetyl cysteine plus clomiphene citrate versus metformin and clomiphene citrate in treatment of clomiphene-resistant polycystic ovary syndrome: a randomized controlled trial. Journal of women's health (2002), 2010, Volume: 19, Issue:11 Topics: Abortion, Spontaneous; Acetylcysteine; Adult; Clomiphene; Drug Resistance; Drug Therapy, Combination; Endometrium; Estrogens; Female; Follow-Up Studies; Humans; Metformin; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Outcome; Progesterone; Prospective Studies	2010
[Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients]. Voprosy onkologii, 2010, Volume: 56, Issue:6 Topics: Acetylcysteine; Aged; Blood Glucose; Body Mass Index; Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Endometrial Neoplasms; Estrogens; Female; Free Radical Scavengers; Glucose; Humans; Hypoglycemic Agents; Interleukin-6; Metformin; Middle Aged; Neoplasms; Postmenopause; Treatment Outcome; Tumor Necrosis Factor-alpha	2010
Clinical, endocrine and metabolic effects of metformin vs N-acetyl-cysteine in women with polycystic ovary syndrome. European journal of obstetrics, gynecology, and reproductive biology, 2011, Volume: 159, Issue:1 Topics: Acetylcysteine; Adolescent; Adult; Anticholesteremic Agents; Antioxidants; Body Mass Index; Female; Hirsutism; Humans; Hyperandrogenism; Hypercholesterolemia; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistance; Menstruation Disturbances; Metformin; Patient Dropouts; Polycystic Ovary Syndrome; Severity of Illness Index; Tumor Necrosis Factor-alpha; Young Adult	2011
N-Acetylcysteine improves oocyte and embryo quality in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection: an alternative to metformin. Reproduction, fertility, and development, 2016, Volume: 28, Issue:6 Topics: Academic Medical Centers; Acetylcysteine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Drug Therapy, Combination; Ectogenesis; Female; Follicular Fluid; Humans; Hypoglycemic Agents; Infertility, Female; Iran; Metformin; Oocyte Retrieval; Oocytes; Oogenesis; Ovulation Induction; Patient Dropouts; Pilot Projects; Polycystic Ovary Syndrome; Sperm Injections, Intracytoplasmic	2016
The adjuvant effect of metformin and N-acetylcysteine to clomiphene citrate in induction of ovulation in patients with Polycystic Ovary Syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2015, Volume: 31, Issue:8 Topics: Acetylcysteine; Adult; Clomiphene; Drug Therapy, Combination; Female; Fertility Agents, Female; Humans; Infertility, Female; Metformin; Ovulation; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate; Treatment Outcome	2015
A comparison between the effects of metformin and N-acetyl cysteine (NAC) on some metabolic and endocrine characteristics of women with polycystic ovary syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2016, Volume: 32, Issue:4 Topics: Acetylcysteine; Adult; Blood Glucose; Double-Blind Method; Female; Free Radical Scavengers; Humans; Hypoglycemic Agents; Insulin; Lipid Metabolism; Metformin; Polycystic Ovary Syndrome; Young Adult	2016
Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome. Journal of gynecology obstetrics and human reproduction, 2017, Volume: 46, Issue:7 Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Adult; Clomiphene; Drug Administration Schedule; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Fertility Agents, Female; Follow-Up Studies; Humans; Infertility, Female; Metformin; Ovulation Induction; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Rate	2017
N-ACETYLCYSTEINE AND/OR URSODEOXYCHOLIC ACID ASSOCIATED WITH METFORMIN IN NON-ALCOHOLIC STEATOHEPATITIS: AN OPEN-LABEL MULTICENTER RANDOMIZED CONTROLLED TRIAL. Arquivos de gastroenterologia, 2019, Aug-13, Volume: 56, Issue:2 Topics: Acetylcysteine; Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Male; Metformin; Middle Aged; Non-alcoholic Fatty Liver Disease; Treatment Outcome; Ursodeoxycholic Acid; Young Adult	2019

Other Studies

19 other study(ies) available for acetylcysteine and metformin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Re: Contrast media-induced nephrotoxicity: identification of patients at risk and algorithms for prevention. Journal of vascular and interventional radiology : JVIR, 2001, Volume: 12, Issue:7 Topics: Acetylcysteine; Contrast Media; Humans; Kidney Diseases; Metformin	2001
Metformin does not prevent DNA damage in lymphocytes despite its antioxidant properties against cumene hydroperoxide-induced oxidative stress. Mutation research, 2006, Dec-10, Volume: 611, Issue:1-2 Topics: Acetylcysteine; Adult; Aged; Aged, 80 and over; Antioxidants; Benzene Derivatives; Cells, Cultured; Comet Assay; DNA Damage; DNA Fragmentation; Female; Humans; Hypoglycemic Agents; Lipid Peroxidation; Lymphocytes; Male; Malondialdehyde; Metformin; Oxidative Stress	2006
Canadian Association of Radiologists: consensus guidelines for the prevention of contrast-induced nephropathy. Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 2007, Volume: 58, Issue:2 Topics: Acetylcysteine; Acute Kidney Injury; Adult; Aging; Child; Chronic Disease; Contrast Media; Drug Interactions; Fluid Therapy; Free Radical Scavengers; Glomerular Filtration Rate; Humans; Hypoglycemic Agents; Kidney Diseases; Metformin; Renal Dialysis; Risk Assessment	2007
[The influence of metformin and N-acetylcysteine on mammographic density in postmenopausal women]. Voprosy onkologii, 2012, Volume: 58, Issue:1 Topics: Acetylcysteine; Aged; Apoptosis; Breast; Breast Neoplasms; Cell Proliferation; DNA Repair; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Mammography; Metformin; Middle Aged; Neoplasms, Hormone-Dependent; Postmenopause; Risk Assessment; Risk Factors	2012
Lowering homocysteine levels may prevent cardiovascular impairments? Possible therapeutic behaviors. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2012, Volume: 23, Issue:8 Topics: Acetylcysteine; Aspirin; Blood Vessels; Cardiovascular Diseases; Clopidogrel; Diuretics; Fatty Acids, Omega-3; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Metformin; Platelet Aggregation Inhibitors; S-Adenosylmethionine; Ticlopidine; Vitamin B 12; Vitamin B 6	2012
Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiation research, 2014, Volume: 181, Issue:5 Topics: Acetylcysteine; Acute Radiation Syndrome; Amifostine; Animals; Captopril; Cell Line, Transformed; Cell Line, Tumor; Cells, Cultured; Colony-Forming Units Assay; Drug Evaluation, Preclinical; Drug Synergism; Endothelial Cells; Fibroblasts; Free Radical Scavengers; Humans; Mesna; Metformin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Radiation Injuries, Experimental; Radiation-Protective Agents; Sarcoma; Sulfhydryl Compounds	2014
Carbonyl traps as potential protective agents against methimazole-induced liver injury. Journal of biochemical and molecular toxicology, 2015, Volume: 29, Issue:4 Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnosine; Chemical and Drug Induced Liver Injury; Male; Metformin; Methimazole; Mice; Necrosis; Oxidative Stress; Protective Agents	2015
Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells. Molecular and cellular endocrinology, 2017, 03-05, Volume: 443 Topics: 4-Chloro-7-nitrobenzofurazan; Acetylcysteine; Adenylate Kinase; Animals; Antioxidants; Cell Line; Deoxyglucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Metformin; Mice; Models, Biological; Muscle Cells; Muscle, Skeletal; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Uric Acid	2017
Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions. International journal of radiation biology, 2017, Volume: 93, Issue:7 Topics: Acetylcysteine; Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Emodin; Female; Metformin; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Radiation Dosage; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Suppressor Protein p53	2017
An In Vitro Study on the Combination Effect of Metformin and N-Acetyl Cysteine against Hyperglycaemia-Induced Cardiac Damage. Nutrients, 2019, Nov-21, Volume: 11, Issue:12 Topics: Acetylcysteine; Animals; Apoptosis; Cardiotonic Agents; Cell Line; Glucose; Hyperglycemia; Lipid Peroxidation; Metformin; Models, Biological; Myocytes, Cardiac; Oxidative Stress; Rats	2019
Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway. Gene, 2020, Jun-30, Volume: 745 Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cisplatin; Colorectal Neoplasms; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Metformin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction	2020
Comparing the acute and chronic effects of metformin and antioxidant protective effects of N-acetyl cysteine on memory retrieval and oxidative stress in rats with Alzheimer's disease. Pakistan journal of pharmaceutical sciences, 2023, Volume: 36, Issue:3 Topics: Acetylcysteine; Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Maze Learning; Metformin; Oxidative Stress; Rats; Streptozocin	2023
Crippling of Klebsiella pneumoniae virulence by metformin, N-acetylcysteine and secnidazole. BMC microbiology, 2023, 08-22, Volume: 23, Issue:1 Topics: Acetylcysteine; Animals; Klebsiella pneumoniae; Metformin; Mice; Virulence; Virulence Factors	2023