Compounds > acetylcysteine

acetylcysteine and lysine

acetylcysteine has been researched along with lysine in 70 studies

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.86)18.7374
1990's11 (15.71)18.2507
2000's40 (57.14)29.6817
2010's11 (15.71)24.3611
2020's6 (8.57)2.80

Authors

AuthorsStudies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Corcoran, GB; Wong, BK1
Kägi, JH; Pande, J; Vasák, M1
Lo, TW; McLellan, AC; Selwood, T; Thornalley, PJ; Westwood, ME1
Stadtman, ER; Uchida, K1
App, EM; Coffiner, M; Fossion, J; King, M; Maes, P; Tomkiewicz, RP1
App, EM; Coffiner, M; De Sanctis, GT; King, M; Maes, P; Rubin, BK; Tomkiewicz, RP1
Dasgupta, B; King, M1
Maes, P; Nève, J; Vanderbist, F1
App, EM; Cantin, AM; Coffiner, M; Gillissen, A; Jaworska, M; Maes, P; Orth, M; Schultze-Werninghaus, G1
Gillissen, A1
Bartling, A; Gillissen, A; Schoen, S; Schultze-Werninghaus, G1
Hoover-Plow, J; Skocir, P1
Moës, AJ; Moyano-Pavon, I; Vanderbist, F; Wery, B1
Alves dos Santos, CM; Govers, R; Strous, GJ; van Kerkhof, P1
Baran, D; Moës, AJ; Schoutens, A; Van Gansbeke, B; Vanderbist, F; Wery, B1
Kamiya, H; Murata-Kamiya, N1
Betz, H; Büttner, C; Griffon, N; Laube, B; Leyendecker, A; Sadtler, S; Schmalzing, G1
Alton, EW; Colledge, WH; Evans, MJ; Farley, R; Ferrari, S; Geddes, DM; Kitson, C; Marriott, C; Parkins, DA; Scarpa, M; Steel, R; Wainwright, B1
App, EM; Baran, D; Coffiner, M; Dab, I; King, M; Malfroot, A; Vanderbist, F1
Antonicelli, F; Donaldson, K; Drost, EM; Hirani, N; MacNee, W; Parmentier, M; Rahman, I1
Hoff, HF; Hoppe, G; O'Neil, J; Salomon, RL; Wu, Z1
De Wit, D; Goldman, M; Nève, J; Verhasselt, V; Vosters, O; Willems, F1
Funk, RH; Geffarth, R; Kasper, M; Reber, F; Reichenbach, A; Schleicher, ED; Siegner, A1
Boehncke, WH; Elliott, PJ; Zollner, TM1
Liu, J; Sayre, LM; Xu, G; Yuan, Q; Zhang, WH1
Chen, L; Smith, JB; Smith, L; Wang, Z1
He, K; Hu, MR; Jin, BF; Lan, Y; Shen, BF; Wang, HX; Wang, J; Wei, KH; Yang, SC; Zhang, XM; Zhou, T1
Borm, PJ; Brown, DM; Dehnhardt, M; Donaldson, K; Gilmour, P; Jimenez, LA; Schins, RP; Stone, V1
Becker, HH; Dopp, E; Lohani, M; Poser, I; Rahman, Q; Schiffmann, D; Weiss, DG; Yadav, S1
Antonicelli, F; Brown, D; Donaldson, K; Drost, EM; Hirani, N; MacNee, W; Parmentier, M; Rahman, I1
Carter, S; Clague, MJ; Urbé, S1
Nagaraj, RH; Staniszewska, MM1
Baer, BR; Henne, KR; Rettie, AE1
Holland, SM; Kishida, KT; Klann, E; Pao, M1
Babar, S; Boudjeltia, KZ; Ducobu, J; Legssyer, I; Moguilevsky, N; Moreau, P; Nève, J; Van Antwerpen, P; Vanhaeverbeek, M1
Bartosz, G; Biliński, T; Kozioł, S; Krzepiłko, A; Zadrag, R; Zyracka, E1
Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW3
Cottalasso, D; Furfaro, AL; Marinari, UM; Menini, S; Odetti, P; Patriarca, S; Pesce, C; Pronzato, MA; Traverso, N1
Abu-El-Ardat, K; Diab-Assaf, M; Harakeh, S; Khalife, J; Niedzwiecki, A; Rath, M1
Cao, H; Hu, J; Kushwah, R; Oliver, JR1
Alipour, M; Omri, A; Smith, MG; Suntres, ZE1
Figarola, JL; Li, Y; Natarajan, R; Rahbar, S; Shanmugam, N; Swiderski, PM1
Cai, W; Chen, X; He, JC; Striker, GE; Vlassara, H; Zhu, L1
Ivanov, V; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, NW1
Beuneu, C; Goldman, M; Verhasselt, V; Vosters, O1
Annangudi, SP; Crabb, JW; Deng, Y; Gu, X; Salomon, RG; Zhang, W1
Gangapurkar, B; Jariwalla, RJ; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW1
Byfield, R; Garcia, ML; Robek, MD1
Jariwalla, RJ; Kalinovsky, T; Niedzwiecki, A; Rath, M; Roomi, MW; Roomi, N1
Lu, D; Peterson, LA; Phillips, MB; Sullivan, MM2
Bumke, MA; ElSohly, MA; Galal, AM; Gul, W; Han, B; Hollingshead, MG; Newton, DL; Slade, D; Stockwin, LH; Yu, SX1
Choudhury, M; Jackson, D; Park, PH; Shukla, SD1
Cosgarea, M; Maniu, A; Perde-Schrepler, M1
Bielefeld, EC; Chen, G; Henderson, D; Hu, B; Yang, W1
Chen, F; Ma, J; Peng, X; Wang, M; Zhang, X1
Gates, LA; Lu, D; Peterson, LA1
Barbanel, G; Billard, JM; Dutar, P; Haxaire, C; Kervern, M; Mothet, JP; Potier, B; Sinet, PM; Turpin, FR1
Alapinar, C; Debelec-Butuner, B; Erbaykent-Tepedelen, B; Gonen-Korkmaz, C; Hamid, SM; Korkmaz, KS; Varisli, L1
Gao, H; Li, C; Lin, D; Peng, Y; Zheng, J1
Bui, LC; Dairou, J; Lamouri, A; Leger, T; Mihoub, M; Richarme, G1
Yin, J; Zhang, S; Zhong, J1
Chen, W; Chen, YH; Ruan, Q; Sun, H; Tang, A; Wan, X; Wang, J; Yan, D; Yang, X; Zamani, A; Zhang, H1
Ghosh, I; Mustafa, S; Pawar, JS1
Ciesielska, K; Muńko, M; Pluskota-Karwatka, D1
Baby, SM; Bates, JN; Gaston, B; Getsy, PM; Hsieh, YH; Lewis, SJ; Lewis, THJ; May, WJ1
Cheng, Y; Cui, J; Mei, G; Peng, S; Peng, Z; Yang, L; Yang, Y1

Reviews

3 review(s) available for acetylcysteine and lysine

ArticleYear
[New perspectives of antioxidant therapy with thiols: nacystelyn].
    Pneumologie (Stuttgart, Germany), 1996, Volume: 50 Suppl 3

    Topics: Acetylcysteine; Antioxidants; Cystic Fibrosis; Expectorants; Humans; Lysine; Prodrugs

1996
Proteasome inhibition: a new anti-inflammatory strategy.
    Journal of molecular medicine (Berlin, Germany), 2003, Volume: 81, Issue:4

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Asthma; Boronic Acids; Bortezomib; Clinical Trials as Topic; Cysteine Endopeptidases; Disease Models, Animal; Humans; Inflammation; Lysine; Models, Biological; Models, Chemical; Multienzyme Complexes; Multiple Sclerosis; Neoplasms; NF-kappa B; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Psoriasis; Pyrazines; Reperfusion Injury

2003
Yeast as a biosensor for antioxidants: simple growth tests employing a Saccharomyces cerevisiae mutant defective in superoxide dismutase.
    Acta biochimica Polonica, 2005, Volume: 52, Issue:3

    Topics: Acetylcysteine; Air; Antioxidants; Atmosphere; Biosensing Techniques; Cysteine; Lysine; Methionine; Mutation; Saccharomyces cerevisiae; Superoxide Dismutase

2005

Trials

2 trial(s) available for acetylcysteine and lysine

ArticleYear
Deposition of nacystelyn from a dry powder inhaler in healthy volunteers and cystic fibrosis patients.
    Drug development and industrial pharmacy, 2001, Volume: 27, Issue:3

    Topics: Absorption; Acetylcysteine; Administration, Inhalation; Adolescent; Adult; Analysis of Variance; Child; Cystic Fibrosis; Expectorants; Female; Humans; Lung; Lysine; Male; Powders; Radionuclide Imaging; Technetium; Tissue Distribution

2001
Dose-finding and 24-h monitoring for efficacy and safety of aerosolized Nacystelyn in cystic fibrosis.
    The European respiratory journal, 2002, Volume: 19, Issue:2

    Topics: Acetylcysteine; Administration, Inhalation; Adolescent; Adult; Aerosols; Cystic Fibrosis; Dose-Response Relationship, Drug; Double-Blind Method; Expectorants; Female; Humans; Lysine; Male; Nebulizers and Vaporizers; Respiratory Mechanics; Sputum; Viscosity

2002

Other Studies

65 other study(ies) available for acetylcysteine and lysine

ArticleYear
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Effects of esterase inhibitors and buthionine sulfoximine on the prevention of acetaminophen hepatotoxicity by N-acetylcysteine.
    Research communications in chemical pathology and pharmacology, 1987, Volume: 55, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Esterases; Isoflurophate; Lysine; Male; Methionine Sulfoximine; Mice; Mice, Inbred ICR; Nitrophenols; Organophosphorus Compounds; Phenylmethylsulfonyl Fluoride

1987
Interaction of lysine residues with the metal thiolate clusters in metallothionein.
    Biochemistry, 1985, Nov-05, Volume: 24, Issue:23

    Topics: Acetylcysteine; Amino Acids; Animals; Cadmium; Circular Dichroism; Edetic Acid; Kinetics; Liver; Lysine; Metallothionein; Nitrobenzenes; Protein Conformation; Rats; Trinitrobenzenesulfonic Acid; Zinc

1985
Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.
    The Journal of biological chemistry, 1994, Dec-23, Volume: 269, Issue:51

    Topics: Acetylcysteine; Arginine; Kinetics; Lysine; Protein Binding; Pyruvaldehyde; Serum Albumin, Bovine

1994
Quantitation of 4-hydroxynonenal protein adducts.
    Methods in enzymology, 1994, Volume: 233

    Topics: Acetylcysteine; Aldehydes; Chromatography, High Pressure Liquid; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Indicators and Reagents; Lipid Peroxidation; Lysine; Protein Binding; Proteins; Radioisotope Dilution Technique; Tritium

1994
Mucolytic treatment with N-acetylcysteine L-lysinate metered dose inhaler in dogs: airway epithelial function changes.
    The European respiratory journal, 1994, Volume: 7, Issue:1

    Topics: Acetylcysteine; Animals; Bronchi; Dogs; Epithelium; In Vitro Techniques; Lysine; Mucociliary Clearance; Mucus; Nebulizers and Vaporizers; Rana pipiens; Rheology; Trachea

1994
A comparison of a new mucolytic N-acetylcysteine L-lysinate with N-acetylcysteine: airway epithelial function and mucus changes in dog.
    Pulmonary pharmacology, 1995, Volume: 8, Issue:6

    Topics: Acetylcysteine; Administration, Inhalation; Animals; Bronchi; Dogs; Expectorants; Female; Lysine; Male; Mucociliary Clearance; Mucus; Trachea; Viscosity

1995
Reduction in viscoelasticity in cystic fibrosis sputum in vitro using combined treatment with nacystelyn and rhDNase.
    Pediatric pulmonology, 1996, Volume: 22, Issue:3

    Topics: Acetylcysteine; Adolescent; Adult; Cystic Fibrosis; Deoxyribonuclease I; Elasticity; Expectorants; Humans; In Vitro Techniques; Lysine; Recombinant Proteins; Rheology; Sputum; Viscosity

1996
In vitro comparative assessment of the antioxidant activity of nacystelyn against three reactive oxygen species.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:8

    Topics: Acetylcysteine; Antioxidants; Captopril; Free Radical Scavengers; Hydrogen Peroxide; Hydroxyl Radical; Hypochlorous Acid; Kinetics; Lysine; Reactive Oxygen Species

1996
Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro.
    Respiratory medicine, 1997, Volume: 91, Issue:3

    Topics: Acetylcysteine; Antioxidants; Cell-Free System; Cells, Cultured; Depression, Chemical; Free Radical Scavengers; Glutathione; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Lysine; Neutrophils; Reactive Oxygen Species

1997
Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro.
    Lung, 1997, Volume: 175, Issue:4

    Topics: Acetylcysteine; Adult; Ambroxol; Antioxidants; Catalase; Expectorants; Female; Free Radical Scavengers; Glutathione; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Lysine; Male; Neutrophils; Reactive Oxygen Species; Superoxide Dismutase

1997
Enzymatic and chemical modifications of lipoprotein(a) selectively alter its lysine-binding functions.
    Biochimica et biophysica acta, 1998, May-20, Volume: 1392, Issue:1

    Topics: Acetylcysteine; Amidines; Binding Sites; Chromatography, Affinity; Copper Sulfate; Homocysteine; Immunoassay; Lipoprotein(a); Lysine; Oxidation-Reduction; Phospholipases A; Phospholipases A2

1998
Optimization of a dry powder inhaler formulation of nacystelyn, a new mucoactive agent.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:11

    Topics: Acetylcysteine; Administration, Inhalation; Capsules; Drug Carriers; Expectorants; Hydrogen-Ion Concentration; Lactose; Lysine; Microscopy, Electron, Scanning; Particle Size; Powders; Solubility

1999
Endocytosis and degradation of the growth hormone receptor are proteasome-dependent.
    The Journal of biological chemistry, 2000, Jan-21, Volume: 275, Issue:3

    Topics: Acetylcysteine; Animals; Blotting, Western; CHO Cells; Cricetinae; Cysteine Proteinase Inhibitors; Endocytosis; Growth Hormone; Ligands; Lysine; Mutagenesis; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Receptors, Somatotropin; Time Factors; Transferrin

2000
Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA.
    Nucleic acids research, 2001, Aug-15, Volume: 29, Issue:16

    Topics: Acetylcysteine; Base Sequence; Binding Sites; Cross-Linking Reagents; Deoxyguanosine; DNA; DNA Polymerase I; DNA Replication; Escherichia coli; Guanine; Hydrogen-Ion Concentration; Kinetics; Lysine; Pyruvaldehyde; Reducing Agents; Substrate Specificity; Templates, Genetic

2001
Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors.
    The Journal of biological chemistry, 2001, Nov-16, Volume: 276, Issue:46

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cell Membrane; Cysteine Endopeptidases; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycine; Histidine; Hydrogen-Ion Concentration; Lysine; Lysosomes; Macrolides; Models, Biological; Multienzyme Complexes; Mutagenesis, Site-Directed; Oocytes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Binding; RNA, Complementary; Ubiquitin; Xenopus

2001
Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium.
    Gene therapy, 2001, Volume: 8, Issue:18

    Topics: Acetylcysteine; Animals; Chloramphenicol O-Acetyltransferase; Cholinergic Antagonists; Cystic Fibrosis; Dose-Response Relationship, Drug; Expectorants; Gene Expression; Genetic Therapy; Genetic Vectors; Glycopyrrolate; Injections, Intramuscular; Lysine; Mice; Mice, Inbred BALB C; Mice, Inbred CFTR; Models, Animal; Nasal Mucosa; Sheep; Trachea

2001
Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells.
    Free radical biology & medicine, 2002, Mar-15, Volume: 32, Issue:6

    Topics: Acetylcysteine; Binding Sites; Cell Line; Chemotaxis; Epithelial Cells; Humans; Hydrogen Peroxide; Interleukin-8; Lysine; NF-kappa B; Oxidants; Oxidation-Reduction; Pulmonary Alveoli; RNA, Messenger; Tumor Necrosis Factor-alpha

2002
Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Feb-01, Volume: 23, Issue:2

    Topics: Acetylcysteine; Aldehydes; Animals; Arteriosclerosis; Biological Transport; Cathepsin B; Cholesterol Esters; Chromatography, Liquid; Humans; Intracellular Membranes; Lipoproteins, LDL; Lysine; Lysosomes; Macrophages, Peritoneal; Mice; Oxidation-Reduction; Phosphatidylcholines; Phospholipids; Pyrroles; Spectrometry, Mass, Electrospray Ionization

2003
Dendritic cells exposed to nacystelyn are refractory to maturation and promote the emergence of alloreactive regulatory t cells.
    Transplantation, 2003, Feb-15, Volume: 75, Issue:3

    Topics: Acetylcysteine; Cell Differentiation; Cells, Cultured; Dendritic Cells; Flow Cytometry; Humans; Immune Tolerance; Lipopolysaccharides; Lysine; T-Lymphocytes; Transplantation Immunology; Transplantation, Homologous

2003
Graded sensitiveness of the various retinal neuron populations on the glyoxal-mediated formation of advanced glycation end products and ways of protection.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2003, Volume: 241, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Dose-Response Relationship, Drug; Female; Glycation End Products, Advanced; Glyoxal; Guanidines; Immunoenzyme Techniques; In Situ Nick-End Labeling; Lysine; Male; Neurons; Niacinamide; Organ Culture Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Retina; Thioctic Acid; Vanadates

2003
Model studies on protein side chain modification by 4-oxo-2-nonenal.
    Chemical research in toxicology, 2003, Volume: 16, Issue:4

    Topics: Acetylcysteine; Aldehydes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Histidine; Imidazoles; Linoleic Acid; Lysine; Magnetic Resonance Spectroscopy; Oxygen; Proteins; Pyrroles; Ribonucleases; Stereoisomerism; Structure-Activity Relationship

2003
Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination.
    Molecular pharmacology, 2003, Volume: 64, Issue:2

    Topics: Acetylcysteine; Apoptosis; Arginine; Caspase 3; Caspases; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Precursors; HL-60 Cells; Humans; Lysine; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Subunits; Proteins; Transfection; Ubiquitin; X-Linked Inhibitor of Apoptosis Protein

2003
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.
    Oncogene, 2003, Jul-31, Volume: 22, Issue:31

    Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Diamines; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Megakaryoblastic, Acute; Leupeptins; Lysine; Multienzyme Complexes; Oligodeoxyribonucleotides, Antisense; Peptide Initiation Factors; Peptide Mapping; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteomics; RNA-Binding Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin

2003
Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:2

    Topics: Acetylcysteine; Air Pollutants; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Carbon; Chelating Agents; Egtazic Acid; Gene Expression; Lysine; Macrophages, Alveolar; Male; Particle Size; Rats; Rats, Wistar; Reactive Oxygen Species; RNA, Messenger; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Verapamil

2004
Modulation of genotoxic effects in asbestos-exposed primary human mesothelial cells by radical scavengers, metal chelators and a glutathione precursor.
    Mutation research, 2004, Apr-11, Volume: 559, Issue:1-2

    Topics: Acetylcysteine; Asbestos, Crocidolite; Asbestos, Serpentine; Chelating Agents; Deferoxamine; Epithelial Cells; Free Radical Scavengers; Humans; Kinetochores; Lysine; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenesis; Phytic Acid; Superoxide Dismutase; Thiourea

2004
Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:6

    Topics: Acetylcysteine; Animals; Antioxidants; Cells, Cultured; Chemotaxis; Cycloheximide; Enzyme Inhibitors; Gene Expression; Humans; In Vitro Techniques; Interleukin-8; Lipopolysaccharides; Lysine; Male; Monocytes; Neutrophils; Okadaic Acid; Pneumonia; Protein Synthesis Inhibitors; Rats; Rats, Wistar; RNA, Messenger; Transcription Factors

2004
The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity.
    The Journal of biological chemistry, 2004, Dec-17, Volume: 279, Issue:51

    Topics: Acetylcysteine; beta Catenin; Cell Line; Cell Line, Tumor; Cytoskeletal Proteins; Cytosol; Down-Regulation; Endosomes; Enzyme Inhibitors; Green Fluorescent Proteins; HeLa Cells; Hepatocyte Growth Factor; Humans; Lysine; Lysosomes; Phosphorylation; Point Mutation; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Recombinant Proteins; Time Factors; Trans-Activators; Transfection; Ubiquitin

2004
3-hydroxykynurenine-mediated modification of human lens proteins: structure determination of a major modification using a monoclonal antibody.
    The Journal of biological chemistry, 2005, Jun-10, Volume: 280, Issue:23

    Topics: Acetylcysteine; Antibodies, Monoclonal; Antigens; Arginine; Binding, Competitive; Blotting, Western; Cell Membrane; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Histidine; Humans; Immunohistochemistry; Kynurenine; Lens, Crystalline; Lysine; Magnetic Resonance Spectroscopy; Models, Chemical; Ninhydrin; Oxygen; Protein Conformation; Spectrophotometry; Time Factors; Tryptophan; Water

2005
Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
    Chemical research in toxicology, 2005, Volume: 18, Issue:5

    Topics: Acetylcysteine; Aldehydes; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 Enzyme System; Glutathione; Humans; Liver; Lung; Lysine; NADP; Pyrroles; Rabbits; Spectrometry, Mass, Electrospray Ionization; Terpenes

2005
NADPH oxidase is required for NMDA receptor-dependent activation of ERK in hippocampal area CA1.
    Journal of neurochemistry, 2005, Volume: 94, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcysteine; Animals; Azoles; Blotting, Western; Catalase; Catecholamines; Dopamine Agonists; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Free Radical Scavengers; Hippocampus; Imidazolines; In Vitro Techniques; Isoindoles; Lysine; Metalloporphyrins; Mice; Mice, Inbred C57BL; N-Methylaspartate; NADPH Oxidases; Neurons; NG-Nitroarginine Methyl Ester; Organoselenium Compounds; Patch-Clamp Techniques; Phosphorylation; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Superoxide Dismutase

2005
Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation.
    Biochemical and biophysical research communications, 2005, Nov-11, Volume: 337, Issue:1

    Topics: Acetylcysteine; Antioxidants; Captopril; Chlorides; Flufenamic Acid; Glutathione; Hydrogen Peroxide; Lipoproteins, LDL; Lysine; Oxidation-Reduction; Peroxidase; Sulfhydryl Compounds

2005
Anti-angiogenic effects of a nutrient mixture on human umbilical vein endothelial cells.
    Oncology reports, 2005, Volume: 14, Issue:6

    Topics: Acetylcysteine; Angiogenesis Inhibitors; Arginine; Ascorbic Acid; Capillaries; Cell Line; Cell Movement; Cell Proliferation; Copper; Culture Media; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Lysine; Manganese; Matrix Metalloproteinase 2; Plant Extracts; Proline; Selenium; Tea; Umbilical Veins

2005
HNE-dependent molecular damage in diabetic nephropathy and its possible prevention by N-acetyl-cysteine and oxerutin.
    BioFactors (Oxford, England), 2005, Volume: 24, Issue:1-4

    Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cell Division; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Hydroxyethylrutoside; Immunohistochemistry; Kidney Glomerulus; Lipid Peroxidation; Lysine; Male; Rats; Rats, Wistar; Taurine

2005
Apoptosis induction by Epican Forte in HTLV-1 positive and negative malignant T-cells.
    Leukemia research, 2006, Volume: 30, Issue:7

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arginine; Ascorbic Acid; Catechin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Copper; Dietary Supplements; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Profiling; Human T-lymphotropic virus 1; Humans; Lysine; Manganese; Proline; Reverse Transcriptase Polymerase Chain Reaction; Selenium; Sensitivity and Specificity; Structure-Activity Relationship; T-Lymphocytes; Transforming Growth Factors

2006
Nacystelyn enhances adenoviral vector-mediated gene delivery to mouse airways.
    Gene therapy, 2007, Volume: 14, Issue:16

    Topics: Acetylcysteine; Adenoviridae; Animals; Cell Line; DEAE-Dextran; Expectorants; Gene Expression; Genetic Therapy; Genetic Vectors; Lac Operon; Lung; Lysine; Mice; Mice, Inbred C57BL; Staining and Labeling; Transduction, Genetic

2007
Inhibition of glioma cell line A-172 MMP activity and cell invasion in vitro by a nutrient mixture.
    Medical oncology (Northwood, London, England), 2007, Volume: 24, Issue:2

    Topics: Acetylcysteine; Amino Acids; Antineoplastic Agents; Arginine; Ascorbic Acid; Camellia sinensis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen; Drug Combinations; Glioma; Humans; Laminin; Lysine; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Invasiveness; Plant Extracts; Proline; Proteoglycans

2007
Prophylactic effect of liposomal N-acetylcysteine against LPS-induced liver injuries.
    Journal of endotoxin research, 2007, Volume: 13, Issue:5

    Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Chloramines; Disease Models, Animal; Lipid Peroxidation; Lipopolysaccharides; Liver; Lysine; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha

2007
Proinflammatory effects of advanced lipoxidation end products in monocytes.
    Diabetes, 2008, Volume: 57, Issue:4

    Topics: Acetylcysteine; Animals; Cell Line; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Glucose; Glycation End Products, Advanced; Humans; Inflammation; Lipid Peroxidation; Lysine; Monocytes; NF-kappa B; Rats; Receptors, CCR2

2008
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.
    American journal of physiology. Cell physiology, 2008, Volume: 294, Issue:1

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Antioxidants; Cell Line; Chromones; Down-Regulation; Forkhead Box Protein O3; Forkhead Transcription Factors; Glycation End Products, Advanced; Humans; Lysine; Morpholines; Mutation; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyruvaldehyde; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, Immunologic; RNA Interference; RNA, Small Interfering; Serine; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Superoxide Dismutase; Transfection

2008
Inhibition of 7,12-dimethylbenzanthracene-induced skin tumors by a nutrient mixture.
    Medical oncology (Northwood, London, England), 2008, Volume: 25, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylcysteine; Amino Acids; Animals; Arginine; Ascorbic Acid; Camellia sinensis; Carcinogens; Copper; Diet; Female; Keratoacanthoma; Lysine; Manganese; Mice; Mice, Inbred SENCAR; Papilloma; Plant Extracts; Proline; Selenium; Skin; Skin Neoplasms

2008
N-acetylcysteine derivative inhibits CD40-dependent proinflammatory properties of human pancreatic duct cells.
    Pancreas, 2008, Volume: 36, Issue:4

    Topics: Acetylcysteine; Adenocarcinoma; CD40 Antigens; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Lysine; NF-kappa B; Pancreatic Ducts; Pancreatic Neoplasms; Transcription, Genetic

2008
Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE.
    Chemical research in toxicology, 2008, Volume: 21, Issue:7

    Topics: Acetylcysteine; Aldehydes; Cross-Linking Reagents; Histidine; Lipoproteins, LDL; Lysine; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors

2008
A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice.
    Human & experimental toxicology, 2008, Volume: 27, Issue:3

    Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Ascorbic Acid; Aspartate Aminotransferases; Blood Urea Nitrogen; Creatinine; Kidney; Liver; Lysine; Male; Mice; Mice, Inbred ICR; Organ Size; Proline; Tea

2008
Suppression of influenza A virus nuclear antigen production and neuraminidase activity by a nutrient mixture containing ascorbic acid, green tea extract and amino acids.
    BioFactors (Oxford, England), 2007, Volume: 31, Issue:1

    Topics: Acetylcysteine; Animals; Antigens, Viral; Ascorbic Acid; Cell Line; Cell Survival; Chlorocebus aethiops; Culture Media; Dogs; Flavonoids; Influenza A virus; Lysine; Neuraminidase; Nucleocapsid Proteins; Phenols; Polyphenols; Proline; RNA-Binding Proteins; Tea; Vero Cells; Viral Core Proteins

2007
Hepatitis B virus replication and release are independent of core lysine ubiquitination.
    Journal of virology, 2009, Volume: 83, Issue:10

    Topics: Acetylcysteine; Animals; Cell Line, Tumor; Cell Nucleolus; DNA, Viral; Gene Expression Regulation, Viral; Hepatitis B virus; Humans; Interferon-alpha; Lysine; Mice; Mutagenesis, Site-Directed; Mutation; Proteasome Endopeptidase Complex; Protein Transport; Ubiquitin; Ubiquitination; Viral Core Proteins; Virion; Virus Replication

2009
Inhibition of cellular invasive parameters in influenza A virus-infected MDCK and Vero cells by a nutrient mixture.
    BioFactors (Oxford, England), 2008, Volume: 33, Issue:1

    Topics: Acetylcysteine; Animals; Apoptosis; Arginine; Ascorbic Acid; Cell Line; Cell Movement; Cell Survival; Chlorocebus aethiops; Dogs; Influenza A virus; Lysine; Matrix Metalloproteinase 9; Orthomyxoviridae Infections; Plant Extracts; Tea; Vero Cells

2008
Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan.
    Chemical research in toxicology, 2009, Volume: 22, Issue:6

    Topics: Acetylcysteine; Aldehydes; Animals; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Furans; Glutathione; Hepatocytes; Humans; Lysine; Male; Rats

2009
Artemisinin dimer anticancer activity correlates with heme-catalyzed reactive oxygen species generation and endoplasmic reticulum stress induction.
    International journal of cancer, 2009, Sep-15, Volume: 125, Issue:6

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Artemisia; Artemisinins; Biomarkers; Blotting, Western; Calcium; Cell Cycle; Dimerization; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Profiling; Heme; Heme Oxygenase-1; Humans; Lysine; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin

2009
Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes.
    Alcohol (Fayetteville, N.Y.), 2010, Volume: 44, Issue:6

    Topics: Acetylation; Acetylcysteine; Alcohol Dehydrogenase; Animals; Antioxidants; Cells, Cultured; Ethanol; Free Radical Scavengers; Glutathione; Hepatocytes; Histones; Hydrogen Peroxide; Lysine; Male; Mitochondria, Liver; NADP; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger

2010
Protective effect of L-N-acetylcysteine against gentamycin ototoxicity in the organ cultures of the rat cochlea.
    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2011, Volume: 52, Issue:1

    Topics: Acetylcysteine; Animals; Cochlea; Dissection; Gentamicins; Hair Cells, Auditory; Lysine; Organ Culture Techniques; Protective Agents; Rats

2011
[L-NAC protect hair cells in the rat cochlea from injury of exposure to styrene].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2011, Volume: 25, Issue:4

    Topics: Acetylcysteine; Animals; Antioxidants; Cochlea; Evoked Potentials, Auditory, Brain Stem; Hair Cells, Auditory; Lysine; Rats; Rats, Long-Evans; Styrene

2011
Dual effects of phloretin and phloridzin on the glycation induced by methylglyoxal in model systems.
    Chemical research in toxicology, 2011, Aug-15, Volume: 24, Issue:8

    Topics: Acetylcysteine; Amino Acid Sequence; Arginine; Creatine Kinase; Lysine; Models, Molecular; Peptides; Phloretin; Phlorhizin; Protein Binding; Pyruvaldehyde; Spectrometry, Mass, Electrospray Ionization

2011
Polyamines are traps for reactive intermediates in furan metabolism.
    Chemical research in toxicology, 2011, Nov-21, Volume: 24, Issue:11

    Topics: Acetylcysteine; Aldehydes; Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Environmental Pollution; Furans; Glutamine; Glutathione; Hepatocytes; Humans; Liver; Lysine; Mass Spectrometry; Ornithine; Oxidation-Reduction; Putrescine; Pyrroles; Rats; Spermidine

2011
Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3

    Topics: Acetylcysteine; Aldehydes; Animals; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Furans; Glutathione; Humans; Lysine; Mice; Microsomes, Liver; Oxidation-Reduction; Oxidoreductases; Rats; Tandem Mass Spectrometry

2012
Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting D-serine-dependent NMDA receptor activation.
    Aging cell, 2012, Volume: 11, Issue:2

    Topics: Acetylcysteine; Aging; Animals; Hippocampus; Lysine; Male; Neuronal Plasticity; Oxidative Stress; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine

2012
Inflammation-mediated abrogation of androgen signaling: an in vitro model of prostate cell inflammation.
    Molecular carcinogenesis, 2014, Volume: 53, Issue:2

    Topics: Acetylcysteine; Androgens; Antioxidants; Apoptosis; Cell Differentiation; Cell Line, Tumor; Down-Regulation; Glutathione Peroxidase; Homeodomain Proteins; Humans; I-kappa B Proteins; Inflammation; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Kallikreins; Lysine; Macrophages; Male; Matrix Metalloproteinase 9; NF-kappa B; Phosphorylation; Prostate-Specific Antigen; Prostatic Neoplasms; Prostatitis; Proto-Oncogene Proteins c-mdm2; Reactive Oxygen Species; Receptors, Androgen; Signal Transduction; Transcription Factors; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; U937 Cells; Up-Regulation

2014
Cytochrome p450-mediated metabolic activation of diosbulbin B.
    Drug metabolism and disposition: the biological fate of chemicals, 2014, Volume: 42, Issue:10

    Topics: Acetylcysteine; Activation, Metabolic; Animals; Bile; Cytochrome P-450 CYP3A; Glutathione; Heterocyclic Compounds, 4 or More Rings; Humans; Ketoconazole; Lysine; Male; Microsomes, Liver; Rats; Urine

2014
Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues.
    The Journal of biological chemistry, 2015, Jan-16, Volume: 290, Issue:3

    Topics: Acetylcysteine; Albumins; Apoptosis; Arginine; Aspartate Aminotransferases; Catalysis; Cell Survival; Cysteine; Escherichia coli; Fructose-Bisphosphate Aldolase; Glucose; Glycolates; Glyoxal; Humans; Intracellular Signaling Peptides and Proteins; Lactates; Lysine; Mass Spectrometry; Oncogene Proteins; Oxidative Stress; Parkinsonian Disorders; Protein Deglycase DJ-1; Pyruvaldehyde

2015
Chaetocin reactivates the lytic replication of Epstein-Barr virus from latency via reactive oxygen species.
    Science China. Life sciences, 2017, Volume: 60, Issue:1

    Topics: Acetylcysteine; Animals; Antigens, Viral; B-Lymphocytes; Blotting, Western; Callithrix; Cell Line, Transformed; Dose-Response Relationship, Drug; Free Radical Scavengers; Gene Expression Regulation; Glutathione Peroxidase; Herpesvirus 4, Human; Histones; Host-Pathogen Interactions; Humans; Lysine; Methylation; NADH Dehydrogenase; Phospholipid Hydroperoxide Glutathione Peroxidase; Piperazines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Virus Activation; Virus Latency; Virus Replication

2017
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis.
    The Journal of experimental medicine, 2020, 02-03, Volume: 217, Issue:2

    Topics: Acetylcysteine; Adoptive Transfer; Animals; Carcinogenesis; Cell Polarity; Cell Transformation, Neoplastic; Female; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myeloid Cells; Myeloid-Derived Suppressor Cells; Reactive Oxygen Species; Signal Transduction; Transfection

2020
Fucoidan induces ROS-dependent epigenetic modulation in cervical cancer HeLa cell.
    International journal of biological macromolecules, 2021, Jun-30, Volume: 181

    Topics: Acetylation; Acetylcysteine; Actins; Autophagosomes; Autophagy; Beclin-1; Cell Survival; Cellular Senescence; Down-Regulation; Epigenesis, Genetic; HeLa Cells; Histone Deacetylases; Histones; Humans; Lysine; Microtubule-Associated Proteins; Mitochondria; Oxidative Stress; Polysaccharides; Reactive Oxygen Species; Superoxides; Vorinostat

2021
New insight into the molecular mechanism of protein cross-linking induced by cis-2-butene-1,4-dial, the metabolite of furan: Formation of 2-substituted pyrrole cross-links involving the cysteine and lysine residues.
    Bioorganic chemistry, 2022, Volume: 125

    Topics: Acetylcysteine; Aldehydes; Animals; Biomarkers; Carcinogens; Chromatography, High Pressure Liquid; Furans; Lysine; Pyrroles; Rats; Tandem Mass Spectrometry

2022
L-NAC reverses of the adverse effects of fentanyl infusion on ventilation and blood-gas chemistry.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 153

    Topics: Acetylcysteine; Analgesics, Opioid; Animals; Fentanyl; Humans; Lysine; Male; Pain; Rats; Rats, Sprague-Dawley

2022
Hexachlorocyclohexane impairs human sperm motility by affecting lysine glutarylation and mitochondrial functions.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2023, Volume: 179

    Topics: Acetylcysteine; Hexachlorocyclohexane; Humans; Lysine; Male; Mitochondria; Reactive Oxygen Species; Semen; Sperm Motility

2023