acetylcysteine and leupeptins

acetylcysteine has been researched along with leupeptins in 254 studies

Research

Studies (254)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's63 (24.80)18.2507
2000's144 (56.69)29.6817
2010's46 (18.11)24.3611
2020's1 (0.39)2.80

Authors

AuthorsStudies
Goldberg, AL; Jensen, TJ; Loo, MA; Pind, S; Riordan, JR; Williams, DB1
Howley, PM; Huibregtse, JM; Maki, CG1
Goldberg, AL; Grimm, LM; Osborne, BA; Poirier, GG; Schwartz, LM1
Becherer, JD; Fernandez, PA; Irmler, M; Maki, M; Martinou, I; Martinou, JC; Quiquerez, AL; Sadoul, R; Schröter, M; Tschopp, J1
Goldberg, AL; Lee, DH2
Darnell, JE; Haspel, RL; Salditt-Georgieff, M1
Benham, A; Braud, V; Cerundolo, V; Gould, K; Macino, B; Mukherjee, S; Neefjes, J; Townsend, A1
Fujita, K; Omura, S; Silver, J1
Cresswell, P; Hammond, C; Hughes, EA1
Bush, KT; Goldberg, AL; Nigam, SK1
Roberts, BJ1
An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L1
Mellgren, RL2
Hara, K; Koide, T; Kozuki, D; Omura, S; Shirotani, H; Tokunaga, F1
Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T1
Bai, A; Forman, J1
Folco, EJ; Koren, G1
Celis, JE; Chen, HY; Davie, JR; Mimnaugh, EG; Neckers, L1
Fischer, JE; Hasselgren, PO; Hobler, SC; Monaco, J; Tiao, G1
Biber, J; Lederer, E; Murer, H; Pfister, MF; Ruf, I; Stange, G; Ziegler, U1
Hyun, WC; Mutomba, MC; To, WY; Wang, CC1
Gabai, VL; Meriin, AB; Sherman, MY; Shifrin, VI; Yaglom, J1
Antón, LC; Bacík, I; Bennink, JR; Bour, S; Cox, JH; Orlowski, M; Schubert, U; Strebel, K; Yewdell, JW1
Arenzana-Seisdedos, F; Friguet, B; Heard, JM; Maréchal, V; Schwartz, O1
Field, MC; Nesbeth, DN; Wainwright, LJ; Wilbourn, B1
Calautti, E; Di Cunto, F; Dotto, GP; Hsiao, J; Ong, L; Seth, PK; Topley, G1
Adeli, K; Gapor, A; Theriault, A; Wang, Q1
Keller, SH; Lindstrom, J; Taylor, P1
Colella, TA; Crotzer, VL; Engelhard, VH; Hunt, DF; King, GM; Luckey, CJ; Maier, BF; Marto, JA; Shabanowitz, J; Venketeswaran, S1
Bercovich, B; Ciechanover, A; Gross-Mesilaty, S; Kahana, C; Reinstein, E; Schwartz, AL; Tobias, KE1
Fang, CH; Fischer, JE; Hasselgren, PO; Hobler, S; Li, BG; Wang, JJ1
Bentley, GV; Grisanti, MS; Murray, EJ; Murray, SS1
Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN1
Deeg, M; Dick, TP; Groll, M; Heinemeyer, W; Huber, R; Keilholz, W; Nussbaum, AK; Rammensee, HG; Schild, H; Schirle, M; Stevanović, S; Wolf, DH1
Chrétien, S; Gisselbrecht, S; Lacombe, C; Mayeux, P; Muller, O; Varlet, P; Verdier, F; Yoshimura, A1
Levine, L2
Di Sano, F; Oliverio, S; Piacentini, M; Spinedi, A1
Adams, J; Brand, S; Conner, EM; Destree, A; Elliott, PJ; Grisham, MB; Mazzola, LM; Palombella, VJ; Parent, L; Pien, C; Wong, HL1
Kim, D; Kim, SH; Li, GC1
Guerra, B; Lanford, RE; Wang, J; White, AL1
Dennis, AP; Lonard, DM; Nawaz, Z; O'Malley, BW; Smith, CL1
Choi, YH; Henkart, PA; Hwang, SG; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, PM; Takano, E; Trepel, JB; Wu, ML1
Chen, BD; Chen, C; Lin, H; Zhang, XM1
Mulligan-Kehoe, MJ; Russo, A1
Banks, L; Mantovani, F1
Irie, S; Katagiri, K; Katagiri, T; Kawashima, S; Kinashi, T; Tanaka, K; Yokosawa, H1
Ancolio, K; Checler, F; da Costa, CA1
Coux, O; Doo, E; Goldberg, AL; Hu, Z; Liang, TJ; Zhang, Z1
Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D1
Redman, C; Xia, H1
Nigam, SK; Tsukamoto, T1
Baldin, V; Brichese, L; Chadebech, P; Valette, A; Vidal, S1
Hunter-Ensor, M; Naidoo, N; Sehgal, A; Song, W1
Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N1
Eitel, K; Hermisson, M; Wagenknecht, B; Weller, M1
Clarke, DM; Loo, TW1
Asuru, A; Boudjelal, M; Fisher, GJ; Kang, S; Li, XY; Peng, ZH; Voorhees, JJ; Xiao, JH1
Kim, D; Li, GC1
Chi, CX; Jiang, Y; Rom, WN; Tchou-Wong, KM; Yie, TA1
Biswal, SS; Datta, K; Kehrer, JP; Robertson, JD1
Koizumi, H; Mano, K; Murata, M; Ohta, K; Yamashita, N1
Guroff, G; Hashimoto, K; Katagiri, Y1
Barbato, C; Calissano, P; Canu, N; Ciotti, MT; Dus, L; Serafino, A1
Doms, RW; Lee, VM; Pijak, DS; Skovronsky, DM1
Carpino, N; Feng, J; Ihle, JN; Marine, JC; Moriggl, R; Stravopodis, D; Teglund, S; Wang, D1
Higasa, T; Kito, M; Kusunose, M; Moriyama, T; Urade, R1
Kaneda, T; Kudo, Y; Miyauchi, M; Nikai, H; Ogawa, I; Sato, S; Takata, T; Takekoshi, T; Zhao, M1
Amsterdam, A; Dantes, A; Dekel, N; Galiani, D; Josefsberg, LB1
Bergmann, C; Del Val, M; Gil-Torregrosa, BC; López, D1
Bohrn, E; Herceg, Z; Wang, ZQ; Wesierska-Gadek, J; Wurzer, G1
Einarson, MB; Fashena, SJ; Golemis, EA; Law, SF; O'Neill, GM1
An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB1
Davie, JR; Lucktong, A; Melkoumian, ZK; Moniwa, M; Strobl, JS; Zhou, Q1
French, OG; Hahn, CS; Kang, BS; Sando, JJ1
Alving, CR; Rao, M; Rothwell, SW; Wassef, NM1
Masaki, R; Ohtani-Kaneko, R; Saito, T; Yamada, K1
Malek, TR; Yu, A1
Hauptmann, S; Leclere, A; Naujokat, C; Possinger, K; Sezer, O; Zinke, H1
Groscurth, P; Hermisson, M; Krammer, PH; Liston, P; Wagenknecht, B; Weller, M1
He, CY; Roos, DS; Shaw, MK; Tilney, LG1
Chau, V; Patnaik, A; Wills, JW1
Ostrand-Rosenberg, S; Qi, L1
Furuta, K; Hanada, S; Harada, M; Kawaguchi, T; Kim, M; Kimura, R; Koga, H; Sakisaka, S; Sata, M; Suganuma, T; Sugiyama, T; Taniguchi, E; Terada, K1
Goldenberg, GJ; Lam, V; McPherson, JP; Salmena, L1
Lemoine, NR; Marani, M; McNeish, I; Tenev, T1
Dautry-Varsat, A; Lamaze, C; Rocca, A; Subtil, A1
Bence, NF; Kopito, RR; Sampat, RM1
Drahushuk, KM; Guo, X; Higgins, D; Horbinski, C; Kaplan, PL; Kim, IJ; Lein, P; Lin, Y; Wang, T1
Mezey, E; Potter, JJ; Rennie-Tankersley, L1
Morley, SJ; Pain, VM1
Almond, JB; Cain, K; Cohen, GM; Dinsdale, D; Hunter, A; Snowden, RT1
Ikemoto, H; Kitagawa, H; Matsumoto, T; Tani, E1
Ashok, BT; Kim, E; Mittelman, A; Tiwari, RK1
Burrows, J; Hale, PD; Hidvegi, T; Perlmutter, DH; Schmidt, B; Teckman, JH1
Kimura, G; Ohtsu, M; Okuda, A1
Ageta, H; Fukazawa, Y; Inokuchi, K; Kato, A; Sugiyama, H1
Hasselgren, PO; Hershko, DD; Hungness, ES; Luo, GJ; Pritts, TA; Robb, BW1
Burton, GR; Lyle, RE; May, JS; McGehee, RE; Prince, AM1
Andreatta, C; Nahreini, P; Prasad, KN1
Blystad, FD; Johannessen, LE; Larsen, AM; Longva, KE; Madshus, IH; Stang, E1
Hui, EK; Nayak, DP1
Bernstein, A; Donoviel, D; Honjo, T; Karlström, H; Lendahl, U; Lundkvist, J; Mizutani, T; Otaka, A; Taniguchi, Y; Vestling, M1
Fischer, JE; Hasselgren, PO; Hershko, DD; Hungness, ES; Luo, GJ; Pritts, TA; Robb, BW; Sun, X; Wong, HR1
Elkon, H; Melamed, E; Offen, D1
Cavaleyra, M; Daulouede, S; Holzmuller, P; Lemesre, JL; Mangot, I; Sereno, D; Vincendeau, P1
Bofinger, D; Chen, CY; Koury, ST; Pajak, L; Tamburlin, J1
Schenkein, D1
Lin, WW; Wen, HC; Wu, HM1
Boone, AN; Vijayan, MM1
Kramer, D; Rondinone, CM1
Chi, KH; Lin, WW; Wu, HM1
Melmed, S; Ren, SG; Yu, R1
Emi, Y; Ikushiro, S; Iyanagi, T; Omura, S1
Lindquist, S; Ma, J1
Dai, W; Darzynkiewicz, Z; Jhanwar-Uniyal, M; Liu, T; Luo, L; Ruan, Q; Traganos, F; Wang, Q; Xie, S1
Bessho, Y; Harada, T; Hirata, H; Kageyama, R; Ohtsuka, T; Yoshikawa, K; Yoshiura, S1
Chaudhary, PM; Matta, H; Sun, Q1
Junn, E; Kim, YM; Lee, G; Mouradian, MM; Tanaka, M1
Hattori, M; Miki, H; Mikoshiba, K; Suetsugu, S; Takenawa, T; Tezuka, T; Yamamoto, T1
Avraham, HK; Miralem, T1
Caplan, AJ; Cardozo, CP; Fliss, AE; Hall, SJ; Michaud, C; Ost, MC; Patterson, C; Yang, E1
Day, BN; McCauley, TC; Sutovsky, M; Sutovsky, P1
Dean, RT; Rodgers, KJ1
Brody, JP; Harris, JW; Lin, F; Thompson, HG; Wold, BJ1
Moreno, MA; Paez, PM; Pasquini, JM; Pasquini, LA; Soto, EF1
Luker, GD; Luker, KE; Pica, CM; Piwnica-Worms, D; Song, J1
Calvaruso, G; D'Anneo, A; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R1
Lenschat, A; Morrison, DC; Perera, PY; Qureshi, N; Shen, J; Splitter, G; Vogel, SN; Zhang, G1
Fukuda, T; Kurosu, T; Miki, T; Miura, O1
He, K; Hu, MR; Jin, BF; Lan, Y; Shen, BF; Wang, HX; Wang, J; Wei, KH; Yang, SC; Zhang, XM; Zhou, T1
Caltagirone, A; Chahine, D; Fillebeen, C; Pantopoulos, K; Segal, P1
Aki, T; Mizukami, Y; Yoshida, K1
Barve, SS; Butt, W; Joshi-Barve, S; Klein, J; McClain, CJ1
Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H1
Delvin, E; Lambert, M; Levy, E; Seidman, E; Ziv, E; Zoltowska, M1
Khor, R; McElroy, LJ; Whittaker, GR1
Bear, MF; Colledge, M; Crozier, RA; Jin, Y; Langeberg, LK; Lu, H; Scott, JD; Snyder, EM; Soderling, JA1
Akaike, A; Ibi, M; Inden, M; Izumi, Y; Kihara, T; Kitamura, Y; Kohno, R; Nakamizo, T; Nakanishi, M; Sakka, N; Sawada, H; Shibasaki, H; Shimohama, S; Taniguchi, T; Yamakawa, K; Yamamoto, N1
Awasthi, N; Wagner, BJ1
Hanson, AJ; Kumar, B; Prasad, KN1
Evdonin, AL; Medvedeva, ND; Nikol'skiĭ, NN; Tsupkina, NV1
Bu, G; Li, Y; Lu, W; Schwartz, AL1
Han, ST; Jin, IN; Kim, OH; Kim, YH; Kwon, TK; Lim, JH; Park, JW; Woo, KJ1
Karube-Harada, A; Nakamura, Y; Sakata, A; Sugino, N; Taketani, T1
Benveniste, EN; Choi, C; Choi, K; Jeong, E; Kwon, D; Park, J1
Chang, YC; Kwon, TK; Lim, JH; Park, JW; Park, YB1
Goldbaum, O; Richter-Landsberg, C1
Liang, JN; Marques, C; Pereira, P; Reddy, VN; Shang, F; Szweda, LI; Taylor, A1
Caamaño, JN; Day, BN; Manandhar, G; McCauley, TC; Sutovsky, M; Sutovsky, P; Thompson, WE1
Bang, JH; Han, ES; Lee, CS; Lim, I1
Bakke, M; Børud, B; Cook, C; Fenne, IS; Hoang, T; Lien, EA; Mellgren, G1
Henfling, ME; Ramaekers, FC; Schutte, B1
Ballestrero, A; Barbieri, E; Belka, C; Brossart, P; Cardone, MH; Dillon, CP; Garuti, A; Hua, F; Nencioni, A; Patrone, F; Rocco, I; Scheiermann, C; Wesselborg, S; Yokoo, R1
Allaman-Pillet, N; Billestrup, N; Bonny, C; Karlsen, AE; Mandrup-Poulsen, T; Størling, J1
Adamo, AM; De Moliner, KL; Perrone Bizzozero, N; Wolfson, ML1
Baumann, G; Black, RA; Cowan, JW; Frank, SJ; Guan, R; He, K; Jiang, J; Wang, X; Wolfe, MS1
Gong, Q; Keeney, DR; Molinari, M; Zhou, Z1
Kabuta, T; Setsuie, R; Wada, K1
Itoh, K; Kobayashi, A; Kumagai, T; Kusano, Y; Osada, S; Uchida, K; Usami, H; Yamamoto, M1
Dong, Y; Liu, B; Mei, ZZ; Song, Y; Sun, GJ; Sun, ZX; Zheng, XF1
Kawatani, Y; Minegishi, N; Shimizu, R; Suzuki, N; Yamamoto, M1
Cheung, NS; Chiu, LL; Choy, MS; Halliwell, B; Kandiah, J; Koay, ES; Lee, AY; Manikandan, J; Melendez, AJ; Ng, WL; Peng, ZF; Qi, RZ; Whiteman, M; Yew, EH1
Jarosz-Wilkołazka, A; Staszczak, M1
Hiramatsu, A; Kiyotani, K; Kuwayama, M; Sakaguchi, T; Shimazu, Y; Sugahara, F; Tanaka, Y; Watanabe, H; Yoshida, T1
Michael Iuvone, P; Rosiak, J; Zawilska, JB1
Boncoeur, E; Bonvin, E; Clement, A; Fritah, A; Henrion-Caude, A; Jacquot, J; Lefait, E; Muselet, C; Redeuilh, G; Tabary, O1
Kaddour-Djebbar, I; Kumar, MV; Lakshmikanthan, V; Lewis, RW; Patel, DM; Shirley, RB1
Basile, DP; Gama, V; Gomez, JA; Haas, AL; Matsuyama, S; Mayo, LD; Yoshida, T1
Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W1
Alao, JP; Coombes, RC; Lam, EW; Stavropoulou, AV; Vigushin, DM1
Hosler, MR; Wagner, BJ; Wang-Su, ST1
Kulms, D; Pöppelmann, B; Schwarz, T; Strozyk, E1
Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W1
Boggaram, V; Das, A1
Jacobs, JM; Nichols, RC; Noreault-Conti, TL; Sinclair, JF; Trask, HW; Wrighton, SA1
Inomata, M; Nakamura, M; Ohno, H; Shintani-Ishida, K; Uemura, K; Yoshida, K1
Biederbick, A; Chen, G; Fillebeen, C; Lill, R; Pantopoulos, K; Wang, J1
Dubey, D; Ganesh, S; Mittal, S; Yamakawa, K1
Inayat-Hussain, SH; Ross, D; Zafar, KS1
Chellas-Géry, B; Fields, KA; Linton, CN1
Furuya, H; Harayama, Y; Imanaka, T; Kashiwayama, Y; Maeda, T; Morita, M; Sato, R; Shimozawa, N; Suzuki, Y; Takahashi, N1
Hainaut, P; Hautefeuille, A; Mion, F; Pétré, A; Roman, S; Scoazec, JY; Thépot, A1
Jiang, T; Liu, J; Shi, L; Wang, J; Wei, L1
Chiou, SK; Mandayam, S1
Kankaanranta, H; Leppänen, T; Moilanen, E; Paukkeri, EL; Sareila, O; Vuolteenaho, K1
Carlsson, T; Karlsson, JO; Petersen, A; Zetterberg, M1
Ishimi, Y; Takezawa, J; Yamada, K1
Akimaru, K; Hirota, R; Nakamura, H1
Campos, EI; Garate, M; Li, G; Wang, Y; Wong, RP1
Dorn, R; Hausott, B; Klimaschewski, L; Schlick, B; Vallant, N1
Bonham, CC; Davisson, VJ; Hindupur, J; Liu, F; Nguyen, JL; Rochet, JC; Ruf, KJ; Schieler, JL; Wood, KV; Zhu, J1
Faustman, EM; Hong, S; Yu, X1
Lim, G; Mao, J; Sung, B; Wang, S; Yang, L1
Faurschou, A; Gniadecki, R1
Ding, J; Feng, JM; Miao, ZH; Zhang, XW; Zhu, H1
Hong, HM; Song, EJ; Yoo, YS1
Fujisawa, E; Koya, D; Ohshima, S; Sasaoka, T; Tsuneki, H; Wada, T1
Hashimoto, T; Ibuki, T; Iwanaga, T; Kishibuchi, R; Kitagawa, H; Mizuguchi, H; Momota, H; Nishihara, S; Onaka, Y; Sado, M; Wada, D; Watanabe, TK; Yamasaki, Y1
Moir, RD; Myre, MA; Tanzi, RE; Tesco, G; Wasco, W; Washicosky, K1
Fu, JJ; Lin, P; Lv, XY; Tsang, BK; Wang, H; Wang, HX; Yan, XJ; Yu, XG; Zhu, C1
Chapman, D; Dhalla, NS; Elimban, V; Maddika, S1
Adeli, K; Qiu, W; Rutledge, AC; Su, Q; Zhang, J1
Chung, RS; Dickson, TC; Staal, JA; Vickers, JC1
Akamatsu, K; Hirano, T; Ichikawa, T; Ichinose, M; Koarai, A; Matsunaga, K; Minakata, Y; Sugiura, H; Yanagisawa, S1
Heikkila, JJ; Young, JT1
Kubo, M; Obata, F; Ohta, E1
Amano, T; Kameyama, N; Mochizuki, H; Nobukuni, M; Okada, S; Sakai, N; Seki, T; Tanaka, A; Yamamoto, H1
Kawakami, T; Kirita, T; Morisugi, T; Tanaka, Y1
Han, YH; Kim, SH; Kim, SZ; Park, WH1
Han, YH; Park, WH1
Han, YH; Kim, SH; Kim, SZ; Moon, HJ; Park, WH; You, BR1
Chen, TC; Ghosh, A; Joo, NE; Kapila, YL1
Han, YH; Kim, SZ; Park, WH; Yang, YM1
Kim, SY; Park, JW1
Bui, TN; Efuet, ET; Keyomarsi, K1
Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM1
Arawaka, S; Fukushima, S; Hara, S; Kato, T; Koyama, S; Machiya, Y; Sakamoto, M; Sato, H1
Gao, G; Luo, H; Wong, J; Zhang, J1
Hamatani, H; Hiromura, K; Kuroiwa, T; Maeshima, A; Nojima, Y; Sakairi, T; Takahashi, S; Takeuchi, S; Tomioka, M1
Amara, A; Arenzana-Seisdedos, F; Bonazzi, M; Cossart, P; Fernandez-Garcia, MD; Meertens, L1
Traynor, JR; Wang, Q1
Chaggar, K; Dolphin, AC; Ferron, L; Page, KM; Waithe, D1
Chodaparambil, JV; Felsher, DW; Huang, M; Kusler, B; Mitchell, BS; Pollyea, DA; Whang, P; Xu, L1
Gui, Y; Jiang, Y; Li, H; Li, J; Yin, H; Zheng, XL1
Fukaya, M; Kaneki, M; Kim, M; Kitamura, T; Mao, J; Shimizu, N; Shinozaki, S; Tamura, Y; Tanioka, T1
Alvarez-Velilla, R; Balaña-Fouce, R; Estrada, CG; Pérez-Pertejo, Y; Reguera, RM1
Fujimuro, M; Higashi, C; Niinaka, Y; Noguchi, K; Saji, C; Yamada, K1
Jitsukawa, M; Kyogoku, H; Miyano, T; Ogushi, S1
Fujita, J; Higashitsuji, H; Itoh, K; Kudo, M; Ryu, U; Sakurai, T1
Ann, EJ; Kim, MY; Kim, SM; Mo, JS; Park, HS; Yoon, JH1
Bekier, ME; Borton, MT; Date, D; Dreier, MR; Taylor, WR1
Ha, YH; Kim, YE; Kwon, HJ; Lee, Y; Park, JA1
Bhattacharya, K; Datta, K; Dutta, D; Li, J; Mandal, C; Pal, BC; Samanta, SK; Sarkar, S1
Baltrusch, S; Hofmeister-Brix, A; Lenzen, S1
Choi, HJ; Crum, TS; Gleixner, AM; Jiang, Y; Leak, RK; Pant, DB; Posimo, JM; Pulugulla, SH; Rumble, JL; Unnithan, AS1
Jeng, CJ; Liao, CK; Wang, HS; Wang, SH; Wu, JC1
Beller, M; Giese, AK; Gläser, A; Lukas, J; Pockrandt, AM; Pohlers, S; Rolfs, A; Runge, F; Seemann, S; Sharif, M; Zheng, C1
Adams, B; Essop, MF; Mapanga, RF1
Goupil, S; Lachance, C; Leclerc, P; Tremblay, RR1
Brilot, F; Fonteneau, JF; Gannagé, M; Münz, C1
Heinemann, SD; Hutchison, DF; Leak, RK; Mason, DM; Posimo, JM1
Khan, NA; Saleem, S; Siddiqui, R1
Bousquet-Dubouch, MP; Burlet-Schiltz, O; Chaoui, K; Gonzalez-de-Peredo, A; Marcellin, M; Matondo, M; Monsarrat, B1
Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS1
Lee, Y; Park, HB; Park, JA; Park, S; Yoo, H1
Bhatia, TN; Brodsky, JL; Flaherty, PT; Gleixner, AM; Hutchison, DF; Leak, LC; Leak, RK; Sannino, S; Wipf, P1
Chatterjee Bhowmick, D; Jeremic, A1
Arbiza, J; Campos, D; González-Santamaría, J; Llamas-González, YY; Pascale, JM1
Han, K; Huang, X; Li, Y; Liu, Q; Liu, Y; Yang, J; Zhang, L; Zhao, D1
Daude, N; Kang, SG; Kar, S; Mays, CE; Westaway, D; Yang, J1
Lee, BH; Nicola, AV; Schneider, SM1

Reviews

3 review(s) available for acetylcysteine and leupeptins

ArticleYear
Proteasome inhibitors: valuable new tools for cell biologists.
    Trends in cell biology, 1998, Volume: 8, Issue:10

    Topics: Acetylcysteine; Animals; Antigen Presentation; Boron Compounds; Cysteine Endopeptidases; Depression, Chemical; Endopeptidases; Heat-Shock Proteins; Humans; Leupeptins; Mammals; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteins; Sulfones; Ubiquitins; Yeasts

1998
Proteasome inhibitors in the treatment of B-cell malignancies.
    Clinical lymphoma, 2002, Volume: 3, Issue:1

    Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Cycle Proteins; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzymes; Gene Expression Regulation; Hodgkin Disease; Humans; Leukemia, B-Cell; Leupeptins; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Mice; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Proteins; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Substrate Specificity; Transcription Factors; Treatment Outcome

2002
Viral entry and the ubiquitin-proteasome system.
    Cellular microbiology, 2021, Volume: 23, Issue:2

    Topics: Acetylcysteine; Animals; Antiviral Agents; Bortezomib; Host Microbial Interactions; Humans; Leupeptins; Nucleocapsid; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ubiquitin; Virion; Virus Internalization; Virus Physiological Phenomena; Viruses

2021

Other Studies

251 other study(ies) available for acetylcysteine and leupeptins

ArticleYear
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.
    Cell, 1995, Oct-06, Volume: 83, Issue:1

    Topics: Acetylcysteine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endopeptidases; Endoplasmic Reticulum; Humans; Leupeptins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ubiquitins

1995
In vivo ubiquitination and proteasome-mediated degradation of p53(1).
    Cancer research, 1996, Jun-01, Volume: 56, Issue:11

    Topics: Acetylcysteine; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; RNA, Messenger; Tumor Suppressor Protein p53; Ubiquitins

1996
Proteasomes play an essential role in thymocyte apoptosis.
    The EMBO journal, 1996, Aug-01, Volume: 15, Issue:15

    Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; DNA Ligases; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes

1996
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
    The EMBO journal, 1996, Aug-01, Volume: 15, Issue:15

    Topics: Acetylcysteine; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 1; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Ligases; Electrophoresis, Polyacrylamide Gel; Leupeptins; Multienzyme Complexes; Nerve Growth Factors; Neurons; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Rats; Sympathetic Nervous System

1996
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae.
    The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44

    Topics: Acetylcysteine; Animals; Kinetics; Leupeptins; Mammals; Muramidase; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Ubiquitins; Vacuoles

1996
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
    The EMBO journal, 1996, Nov-15, Volume: 15, Issue:22

    Topics: Acetylcysteine; Blotting, Western; Cell Nucleus; Cysteine Endopeptidases; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Humans; Interferon-gamma; Leupeptins; Multienzyme Complexes; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor; Staurosporine; Trans-Activators; Vanadates

1996
The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
    European journal of immunology, 1997, Volume: 27, Issue:1

    Topics: Acetylcysteine; Animals; Antigen-Presenting Cells; Antigens, Viral; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Epitopes; H-2 Antigens; Humans; Leupeptins; Mice; Multienzyme Complexes; Nucleocapsid Proteins; Nucleoproteins; Orthomyxoviridae; Peptides; Proteasome Endopeptidase Complex; Signal Transduction; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Core Proteins

1997
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.
    The Journal of general virology, 1997, Volume: 78 ( Pt 3)

    Topics: Acetylcysteine; Amino Acid Sequence; Brefeldin A; CD4 Antigens; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Products, env; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Signal Transduction; Viral Regulatory and Accessory Proteins

1997
Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Mar-04, Volume: 94, Issue:5

    Topics: Acetylcysteine; beta 2-Microglobulin; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Histocompatibility Antigens Class I; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Folding; Solubility; Transfection; Tumor Cells, Cultured

1997
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
    The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14

    Topics: Acetylcysteine; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Endoplasmic Reticulum; Fungal Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; RNA, Messenger

1997
Evidence of proteasome-mediated cytochrome P-450 degradation.
    The Journal of biological chemistry, 1997, Apr-11, Volume: 272, Issue:15

    Topics: Acetylcysteine; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Leupeptins; Microsomes, Liver; Mixed Function Oxygenases; Multienzyme Complexes; Oxidoreductases, N-Demethylating; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley

1997
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
    Oncogene, 1997, Jun-12, Volume: 14, Issue:23

    Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins

1997
Evidence for participation of a calpain-like cysteine protease in cell cycle progression through late G1 phase.
    Biochemical and biophysical research communications, 1997, Jul-30, Volume: 236, Issue:3

    Topics: Acetylcysteine; Calpain; Cell Cycle; Cell Line; Cysteine Proteinase Inhibitors; Diazomethane; Fibroblasts; G1 Phase; Humans; Leupeptins; Oligopeptides; S Phase

1997
Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors.
    FEBS letters, 1997, Jul-21, Volume: 412, Issue:1

    Topics: Acetylcysteine; Animals; Antithrombin III; Brefeldin A; Cell Line; Cricetinae; Cyclopentanes; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Kidney; Leupeptins; Multienzyme Complexes; Mutagenesis, Site-Directed; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Transfection

1997
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
    Oncogene, 1997, Aug-14, Volume: 15, Issue:7

    Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins

1997
The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.
    Journal of immunology (Baltimore, Md. : 1950), 1997, Sep-01, Volume: 159, Issue:5

    Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cysteine Endopeptidases; Endoplasmic Reticulum; Epitopes; Hexosaminidases; Histocompatibility Antigens Class I; HLA-A2 Antigen; Humans; Leupeptins; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Sorting Signals; Self Tolerance; T-Lymphocytes, Cytotoxic

1997
Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin-proteasome pathway.
    The Biochemical journal, 1997, Nov-15, Volume: 328 ( Pt 1)

    Topics: Acetylcysteine; Animals; Cell Line; Cyclic AMP; Cyclic AMP Response Element Modulator; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Ion Channels; Leupeptins; Multienzyme Complexes; Myocardium; Neurons; Proteasome Endopeptidase Complex; Rats; Repressor Proteins; Transcription, Genetic; Ubiquitins

1997
Specificities of cell permeant peptidyl inhibitors for the proteinase activities of mu-calpain and the 20 S proteasome.
    The Journal of biological chemistry, 1997, Nov-21, Volume: 272, Issue:47

    Topics: Acetylcysteine; Calcium-Binding Proteins; Calpain; Catalysis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diazomethane; Enzyme Precursors; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Muramidase; Oligopeptides; Plant Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Serine Proteinase Inhibitors; Ubiquitins

1997
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.
    Biochemistry, 1997, Nov-25, Volume: 36, Issue:47

    Topics: Acetylcysteine; Breast Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; DNA Replication; Female; Histones; Hot Temperature; Humans; Leupeptins; Multienzyme Complexes; Nucleoproteins; Nucleosomes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitins

1997
Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors.
    The American journal of physiology, 1998, Volume: 274, Issue:1

    Topics: Acetylcysteine; Animals; Cecum; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Kinetics; Leupeptins; Male; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Transcription, Genetic; Ubiquitins

1998
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Feb-17, Volume: 95, Issue:4

    Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters

1998
Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes.
    Molecular and biochemical parasitology, 1997, Dec-15, Volume: 90, Issue:2

    Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Flow Cytometry; Interphase; Leupeptins; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; S Phase; Trypanosoma brucei brucei

1997
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis.
    The Journal of biological chemistry, 1998, Mar-13, Volume: 273, Issue:11

    Topics: Acetylcysteine; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Leupeptins; Lymphoma; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Tumor Cells, Cultured

1998
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.
    Journal of virology, 1998, Volume: 72, Issue:3

    Topics: Acetylcysteine; Calcium-Binding Proteins; Calnexin; CD4 Antigens; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Cytosol; Enzyme Activation; Glycoproteins; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Multienzyme Complexes; Mutagenesis; Proteasome Endopeptidase Complex; Ubiquitins; Viral Regulatory and Accessory Proteins

1998
Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1.
    Journal of virology, 1998, Volume: 72, Issue:5

    Topics: Acetylcysteine; beta-Galactosidase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Viral; Gene Products, tat; HeLa Cells; HIV Core Protein p24; HIV-1; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; tat Gene Products, Human Immunodeficiency Virus; Tumor Cells, Cultured

1998
Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition.
    The Biochemical journal, 1998, May-15, Volume: 332 ( Pt 1)

    Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylphosphatidylinositols; Human Growth Hormone; Humans; Leupeptins; Multienzyme Complexes; Mutation; Peptides; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sulfhydryl Compounds; Ubiquitins

1998
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.
    Science (New York, N.Y.), 1998, May-15, Volume: 280, Issue:5366

    Topics: Acetylcysteine; Adenoviridae; Animals; Animals, Newborn; Cell Cycle; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Gene Expression Regulation; Keratinocytes; Leupeptins; Membrane Proteins; Mice; Mutation; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Succinates; Transfection

1998
Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway.
    Biochemical and biophysical research communications, 1998, May-29, Volume: 246, Issue:3

    Topics: Acetylcysteine; Apolipoproteins B; Biological Transport; Cell Membrane Permeability; Chromans; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leupeptins; Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Tumor Cells, Cultured; Vitamin E

1998
Inhibition of glucose trimming with castanospermine reduces calnexin association and promotes proteasome degradation of the alpha-subunit of the nicotinic acetylcholine receptor.
    The Journal of biological chemistry, 1998, Jul-03, Volume: 273, Issue:27

    Topics: Acetylcysteine; Biopolymers; Calcium-Binding Proteins; Calnexin; Calreticulin; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimerization; DNA, Complementary; Glucose; Heat-Shock Proteins; Humans; Hydrolysis; Indolizines; Isomerases; Leupeptins; Multienzyme Complexes; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Binding; Protein Disulfide-Isomerases; Receptors, Nicotinic; Ribonucleoproteins; Transfection; Ubiquitins

1998
Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Jul-01, Volume: 161, Issue:1

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Glycine; Histocompatibility Antigens Class I; HLA-A Antigens; Humans; Leupeptins; Membrane Proteins; Mice; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Time Factors; Viral Matrix Proteins

1998
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, Jul-07, Volume: 95, Issue:14

    Topics: Acetylcysteine; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leupeptins; Neuroblastoma; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus Infections; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Tumor Virus Infections; Ubiquitins

1998
Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats.
    Clinical science (London, England : 1979), 1998, Volume: 95, Issue:2

    Topics: Acetylcysteine; Animals; Burns; Culture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Lactones; Leupeptins; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tyrosine; Ubiquitins

1998
The ubiquitin-proteasome system and cellular proliferation and regulation in osteoblastic cells.
    Experimental cell research, 1998, Aug-01, Volume: 242, Issue:2

    Topics: Acetylcysteine; Animals; Biopolymers; Cell Division; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Proteasome Endopeptidase Complex; Second Messenger Systems; Teriparatide; Tumor Cells, Cultured; Ubiquitins

1998
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
    Cardiovascular research, 1998, Volume: 38, Issue:3

    Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats

1998
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants.
    The Journal of biological chemistry, 1998, Oct-02, Volume: 273, Issue:40

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Fluorescence; Fungal Proteins; Histocompatibility Antigens Class I; Isocoumarins; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Vertebrates

1998
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
    The Journal of biological chemistry, 1998, Oct-23, Volume: 273, Issue:43

    Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Immediate-Early Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Tyrosine; Ubiquitins

1998
Proteolysis negatively regulates agonist-stimulated arachidonic acid metabolism.
    Cellular signalling, 1998, Volume: 10, Issue:9

    Topics: Acetylcysteine; Animals; Arachidonic Acid; Carcinogens; Cell Line; Endopeptidases; Epoprostenol; Leupeptins; Lyngbya Toxins; Phenylmethylsulfonyl Fluoride; Prostaglandin-Endoperoxide Synthases; Protease Inhibitors; Rats; Signal Transduction

1998
Calpain involvement in calphostin C-induced apoptosis.
    Biochemical pharmacology, 1998, Dec-01, Volume: 56, Issue:11

    Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Naphthalenes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; U937 Cells; Ubiquitins

1998
Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome.
    Methods in enzymology, 1999, Volume: 300

    Topics: Acetylcysteine; Animals; Arthritis; Boronic Acids; Cell Adhesion Molecules; Cytokines; Dipeptides; Endothelium, Vascular; Female; HeLa Cells; Humans; Hypersensitivity, Delayed; Jurkat Cells; Leupeptins; NF-kappa B; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Rats, Inbred Lew; T-Lymphocytes

1999
Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression.
    Biochemical and biophysical research communications, 1999, Jan-08, Volume: 254, Issue:1

    Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Fibroblasts; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Phosphorylation; Receptors, Estrogen; Transcription Factors

1999
Presecretory degradation of apolipoprotein [a] is mediated by the proteasome pathway.
    Journal of lipid research, 1999, Volume: 40, Issue:2

    Topics: Acetylcysteine; Animals; Apolipoproteins A; Calnexin; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fabaceae; Hepatocytes; Hexosaminidases; Leupeptins; Mannosidases; Molecular Chaperones; Multienzyme Complexes; Papio; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Transfection; Ubiquitin

1999
Proteasome-dependent degradation of the human estrogen receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-02, Volume: 96, Issue:5

    Topics: Acetylcysteine; Animals; Arabidopsis; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Escherichia coli; Estradiol; HeLa Cells; Humans; Kinetics; Leupeptins; Mammals; Multienzyme Complexes; Proteasome Endopeptidase Complex; Receptors, Estrogen; Receptors, Progesterone; Receptors, Thyroid Hormone; Recombinant Proteins; Substrate Specificity; Transfection; Ubiquitins

1999
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
    Oncogene, 1999, Mar-11, Volume: 18, Issue:10

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Bucladesine; Calpain; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Dipeptides; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketones; Leupeptins; Lovastatin; Nuclear Proteins; Protein Processing, Post-Translational; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Tumor Cells, Cultured

1999
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells.
    The Biochemical journal, 1999, May-15, Volume: 340 ( Pt 1)

    Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia; Leupeptins; Molecular Weight; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Signal Transduction; Time Factors; Tumor Cells, Cultured; Ubiquitins

1999
Inhibition of cytoplasmic antigen, glucose- 6-phosphate dehydrogenase, by VH-CH1, an intracellular Fd fragment antibody derived from a semisynthetic Fd fragment phage display library.
    Journal of molecular biology, 1999, May-28, Volume: 289, Issue:1

    Topics: Acetylcysteine; Animals; Cell Line; Cricetinae; Cricetulus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Inovirus; Isopropyl Thiogalactoside; Kinetics; Leupeptins; Multienzyme Complexes; Peptide Library; Proteasome Endopeptidase Complex; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection

1999
Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines.
    Oncogene, 1999, Jun-03, Volume: 18, Issue:22

    Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Female; Fibrosarcoma; Humans; Leupeptins; Mitomycin; Oncogene Proteins, Viral; Papillomaviridae; Polymorphism, Genetic; Repressor Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms

1999
Ubiquitin-proteasome system is involved in induction of LFA-1/ICAM-1-dependent adhesion of HL-60 cells.
    Journal of leukocyte biology, 1999, Volume: 65, Issue:6

    Topics: Acetylcysteine; Adenosine Triphosphatases; Antibody Affinity; Cell Adhesion; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HL-60 Cells; Humans; Intercellular Adhesion Molecule-1; Leupeptins; Lymphocyte Function-Associated Antigen-1; Monocytes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tetradecanoylphorbol Acetate; Tretinoin; Ubiquitins

1999
C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
    Molecular medicine (Cambridge, Mass.), 1999, Volume: 5, Issue:3

    Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycopeptides; Humans; Leucine; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Pepstatins; Presenilin-1; Presenilin-2; Proteasome Endopeptidase Complex; Recombinant Proteins; Sulfones; Transfection

1999
Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex.
    Journal of virology, 1999, Volume: 73, Issue:9

    Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hepatitis B virus; Humans; Leupeptins; Multienzyme Complexes; Peptide Hydrolases; Proteasome Endopeptidase Complex; Substrate Specificity; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Ubiquitins; Viral Regulatory and Accessory Proteins

1999
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
    Oncogene, 1999, Jul-29, Volume: 18, Issue:30

    Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins

1999
The degradation of nascent fibrinogen chains is mediated by the ubiquitin proteasome pathway.
    Biochemical and biophysical research communications, 1999, Aug-11, Volume: 261, Issue:3

    Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Immunosorbent Techniques; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Transfection; Ubiquitins

1999
Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome.
    The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35

    Topics: Acetylcysteine; Animals; Cadherins; Cell Line; Cell Movement; Chemotaxis; Connexins; Cysteine Endopeptidases; Dogs; Epithelial Cells; Hepatocyte Growth Factor; Immunohistochemistry; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oncogene Protein pp60(v-src); Phosphoproteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Tight Junctions; Zonula Occludens-1 Protein

1999
Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage.
    Biochemical and biophysical research communications, 1999, Sep-07, Volume: 262, Issue:3

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Leupeptins; Microtubules; Mitosis; Multienzyme Complexes; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Virulence Factors, Bordetella

1999
A role for the proteasome in the light response of the timeless clock protein.
    Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434

    Topics: Acetylcysteine; Animals; Biological Clocks; Cells, Cultured; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Darkness; Drosophila; Drosophila Proteins; Feedback; Insect Proteins; Leucine; Leupeptins; Light; Multienzyme Complexes; Neurons; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitins

1999
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
    International journal of oncology, 1999, Volume: 15, Issue:4

    Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins

1999
Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 1999, Volume: 9, Issue:3

    Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glioma; Glycoproteins; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1999
The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:13

    Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Multiple; Glycosylation; Humans; Leupeptins; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Precursors; Protein Processing, Post-Translational

1999
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:10

    Topics: Acetylcysteine; Administration, Topical; Calcitriol; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Gene Expression Regulation; Humans; Keratinocytes; Leucine; Leupeptins; Multienzyme Complexes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Receptors, Calcitriol; Skin; Steroid Hydroxylases; Ubiquitins; Vitamin D3 24-Hydroxylase

1999
Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression.
    Biochemical and biophysical research communications, 1999, Oct-22, Volume: 264, Issue:2

    Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Hot Temperature; HSP70 Heat-Shock Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; Transcription Factors

1999
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor.
    Oncogene, 1999, Oct-28, Volume: 18, Issue:44

    Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Carcinogenicity Tests; Cell Differentiation; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, Dominant; Genes, Tumor Suppressor; Humans; Leupeptins; Lung Neoplasms; Mice; Mice, Nude; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tumor Cells, Cultured; Ultraviolet Rays

1999
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.
    The Biochemical journal, 1999, Dec-01, Volume: 344 Pt 2

    Topics: Acetylcysteine; Animals; Apoptosis; B-Lymphocytes; bcl-X Protein; Canavanine; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Synergism; Enzyme Activation; Hematopoietic Stem Cells; HSP70 Heat-Shock Proteins; Interleukin-3; Leupeptins; Mice; Multienzyme Complexes; Oligonucleotides, Antisense; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2

1999
Nuclear factor kappa B mediates interleukin-8 production in eosinophils.
    International archives of allergy and immunology, 1999, Volume: 120, Issue:3

    Topics: Acetylcysteine; Cell Nucleus; Cysteine Proteinase Inhibitors; Densitometry; Electrophoresis; Enzyme-Linked Immunosorbent Assay; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunohistochemistry; Immunosuppressive Agents; Interleukin-8; Leupeptins; NF-kappa B; Tacrolimus; Tumor Necrosis Factor-alpha

1999
Delayed and sustained activation of p42/p44 mitogen-activated protein kinase induced by proteasome inhibitors through p21(ras) in PC12 cells.
    Journal of neurochemistry, 2000, Volume: 74, Issue:1

    Topics: Acetylcysteine; Animals; Autocrine Communication; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; ets-Domain Protein Elk-1; Leupeptins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Neurites; PC12 Cells; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Rats; Time Factors; Transcription Factors

2000
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-15, Volume: 20, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins

2000
A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
    Biochemistry, 2000, Feb-01, Volume: 39, Issue:4

    Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Binding, Competitive; Cell Compartmentation; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Endoplasmic Reticulum; Humans; Hydrolysis; Intracellular Fluid; Leupeptins; Multienzyme Complexes; Neurons; Peptide Fragments; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Tumor Cells, Cultured

2000
A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.
    The EMBO journal, 2000, Feb-01, Volume: 19, Issue:3

    Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Structure, Secondary; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Tyrosine

2000
Accumulation and degradation in the endoplasmic reticulum of a truncated ER-60 devoid of C-terminal amino acid residues.
    Journal of biochemistry, 2000, Volume: 127, Issue:2

    Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Carrier Proteins; Cell Membrane; COS Cells; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochalasin B; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Half-Life; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Proteins; Molecular Chaperones; Protein Disulfide-Isomerases; Recombinant Proteins; Ribonucleoproteins

2000
p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:3

    Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; Humans; Leupeptins; Microtubule-Associated Proteins; Mouth Mucosa; Mouth Neoplasms; Multienzyme Complexes; Oligonucleotides, Antisense; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Precursors; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Proteins

2000
The proteasome is involved in the first metaphase-to-anaphase transition of meiosis in rat oocytes.
    Biology of reproduction, 2000, Volume: 62, Issue:5

    Topics: Acetylcysteine; Anaphase; Animals; Cyclin B; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Leupeptins; Meiosis; Metaphase; Multienzyme Complexes; Oligopeptides; Oocytes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Spindle Apparatus

2000
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.
    Journal of immunology (Baltimore, Md. : 1950), 2000, May-15, Volume: 164, Issue:10

    Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Hepatitis B e Antigens; Histocompatibility Antigens Class I; HIV Envelope Protein gp160; HIV-1; Humans; Hydrolysis; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic

2000
Differential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors.
    Journal of cellular biochemistry, 2000, Jun-12, Volume: 78, Issue:4

    Topics: Acetylcysteine; Animals; Cell Line; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Fibroblasts; Fluorescent Dyes; Humans; Immunoblotting; Indoles; Leupeptins; Mice; Mice, Knockout; Microscopy, Fluorescence; Multienzyme Complexes; Oligopeptides; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteins; Time Factors; Tumor Suppressor Protein p53

2000
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.
    Molecular and cellular biology, 2000, Volume: 20, Issue:14

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Caspase 3; Caspase 7; Caspase Inhibitors; Caspases; Cell Death; Crk-Associated Substrate Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Mitosis; Multienzyme Complexes; Mutation; Oligopeptides; Peptide Fragments; Phosphoproteins; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Isoforms; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2000
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
    Leukemia, 2000, Volume: 14, Issue:7

    Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells

2000
Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1.
    The Journal of biological chemistry, 2000, Nov-10, Volume: 275, Issue:45

    Topics: Acetylation; Acetylcysteine; Animals; Anti-Bacterial Agents; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chickens; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeleton; Down-Regulation; Enzyme Inhibitors; Female; G1 Phase; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoblotting; Keratins; Leupeptins; Multienzyme Complexes; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Quinidine; Retinoblastoma Protein; Time Factors; Tumor Cells, Cultured

2000
Activation-dependent degradation of protein kinase C eta.
    Oncogene, 2000, Aug-31, Volume: 19, Issue:37

    Topics: Acetylcysteine; Animals; Cell Fractionation; Cell Line; Chick Embryo; Cricetinae; Cysteine Endopeptidases; Detergents; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Humans; Isoenzymes; Kidney; Leupeptins; Membrane Proteins; Mesocricetus; Mice; Multienzyme Complexes; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Conformation; Protein Kinase C; Protein Kinase C-theta; Rats; Recombinant Fusion Proteins; Sindbis Virus; Tumor Cells, Cultured; Ubiquitins

2000
Proteasome inhibitors block the entry of liposome-encapsulated antigens into the classical MHC class I pathway.
    Immunology letters, 2000, Oct-03, Volume: 74, Issue:2

    Topics: Acetylcysteine; Animals; Bone Marrow Cells; Conalbumin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Golgi Apparatus; Histocompatibility Antigens Class I; Leupeptins; Liposomes; Macrophages; Mice; Models, Biological; Multienzyme Complexes; Peptides; Phagocytosis; Proteasome Endopeptidase Complex; Spleen; T-Lymphocytes, Cytotoxic

2000
Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors.
    Journal of neuroscience research, 2000, Oct-01, Volume: 62, Issue:1

    Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Calpain; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neurites; Neurofilament Proteins; PC12 Cells; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-jun; Rats; Ubiquitins

2000
The proteasome regulates receptor-mediated endocytosis of interleukin-2.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Endocytosis; Interleukin-2; Leupeptins; Lysosomes; Macromolecular Substances; Mice; Mice, Inbred C57BL; Milk Proteins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Subunits; Receptors, Interleukin-2; Spleen; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators

2001
Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells.
    European journal of haematology, 2000, Volume: 65, Issue:4

    Topics: Acetylcysteine; Acute Disease; Adult; Antigens, CD34; Apoptosis; Caspase 3; Caspases; Cell Culture Techniques; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Hematopoietic Stem Cells; Humans; K562 Cells; Leukemia; Leupeptins; Mitosis; Multienzyme Complexes; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells

2000
Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
    Journal of neurochemistry, 2000, Volume: 75, Issue:6

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Glioma; Humans; Lactams; Leupeptins; Membrane Glycoproteins; Mice; Mitochondria; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Transgenes; Tumor Cells, Cultured

2000
Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii.
    Parasitology, 2000, Volume: 121 ( Pt 1)

    Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; DNA, Protozoan; Endoplasmic Reticulum; Humans; Leupeptins; Microscopy, Electron; Multienzyme Complexes; Proteasome Endopeptidase Complex; Toxoplasma; Toxoplasmosis; Vacuoles

2000
Ubiquitin is part of the retrovirus budding machinery.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Nov-21, Volume: 97, Issue:24

    Topics: Acetylcysteine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Membrane; Cysteine Endopeptidases; Endocytosis; Gene Products, gag; Leupeptins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Quail; Recombinant Fusion Proteins; Ubiquitins; Virus Replication

2000
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
    Traffic (Copenhagen, Denmark), 2000, Volume: 1, Issue:2

    Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured

2000
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.
    Gastroenterology, 2001, Volume: 120, Issue:4

    Topics: Acetylcysteine; Adenosine Triphosphatases; Carrier Proteins; Cation Transport Proteins; Cell Line; Copper-Transporting ATPases; Cysteine Endopeptidases; Cytoskeleton; Fluorescent Antibody Technique; Humans; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; Tissue Distribution

2001
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.
    Biochemical pharmacology, 2001, Apr-01, Volume: 61, Issue:7

    Topics: Acetylcysteine; Adenosine Triphosphate; Antigens, Neoplasm; Cell Cycle; Cell Extracts; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Isoenzymes; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured

2001
Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.
    Cell death and differentiation, 2001, Volume: 8, Issue:3

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Induction; Female; Flow Cytometry; G2 Phase; Glycoproteins; Humans; Immunoblotting; Isoenzymes; Leupeptins; Ovarian Neoplasms; Transfection

2001
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
    Molecular biology of the cell, 2001, Volume: 12, Issue:5

    Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins

2001
Impairment of the ubiquitin-proteasome system by protein aggregation.
    Science (New York, N.Y.), 2001, May-25, Volume: 292, Issue:5521

    Topics: Acetylcysteine; Amino Acid Sequence; Cell Death; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; G2 Phase; Green Fluorescent Proteins; Humans; Huntingtin Protein; Inclusion Bodies; Leupeptins; Luminescent Proteins; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Nuclear Proteins; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Transfection; Ubiquitins

2001
Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.
    Journal of neurobiology, 2001, Volume: 48, Issue:2

    Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendrites; DNA-Binding Proteins; Gene Expression; Leupeptins; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Superior Cervical Ganglion; Trans-Activators; Transcriptional Activation; Transfection; Transforming Growth Factor beta

2001
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.
    Biochemical and biophysical research communications, 2001, Jul-20, Volume: 285, Issue:3

    Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins

2001
Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
    FEBS letters, 2001, Aug-17, Volume: 503, Issue:2-3

    Topics: Acetylcysteine; Apoptosis; Calpain; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Eukaryotic Initiation Factor-4G; fas Receptor; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Jurkat Cells; Leupeptins; Multienzyme Complexes; Peptide Fragments; Peptide Initiation Factors; Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine; T-Lymphocytes

2001
Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.
    Leukemia, 2001, Volume: 15, Issue:9

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptotic Protease-Activating Factor 1; Blotting, Western; Caspase 9; Caspases; Cysteine Endopeptidases; Cytochrome c Group; Cytosol; Enzyme Activation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leupeptins; Microscopy, Electron; Molecular Weight; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteins; Tumor Cells, Cultured

2001
Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.
    FEBS letters, 2001, Aug-24, Volume: 504, Issue:1-2

    Topics: Acetylcysteine; Apoptosis; Base Sequence; Brain Neoplasms; Cysteine Proteinase Inhibitors; DNA Primers; Fas Ligand Protein; fas Receptor; Glioma; Humans; Leupeptins; Membrane Glycoproteins; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured

2001
Proteasome inhibitors differentially affect heat shock protein response in cancer cells.
    International journal of molecular medicine, 2001, Volume: 8, Issue:4

    Topics: Acetylcysteine; Antigens, Neoplasm; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Heat-Shock Proteins; HL-60 Cells; Humans; K562 Cells; Leupeptins; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Tumor Cells, Cultured

2001
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; HeLa Cells; Hepatocytes; Humans; Lactones; Leupeptins; Liver; Mice; Multienzyme Complexes; Mutation; Oligopeptides; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Rats; Time Factors; Transfection; Tumor Cells, Cultured

2001
Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.
    Cell structure and function, 2001, Volume: 26, Issue:4

    Topics: Acetylcysteine; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genetic Complementation Test; Hybrid Cells; Leupeptins; Multienzyme Complexes; Point Mutation; Proteasome Endopeptidase Complex; Proteins; Rats; Temperature; Ubiquitin

2001
Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins.
    Brain research. Molecular brain research, 2001, Dec-30, Volume: 97, Issue:2

    Topics: Acetylcysteine; Animals; Carrier Proteins; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hippocampus; Homer Scaffolding Proteins; Immunohistochemistry; Leupeptins; Multienzyme Complexes; Neuronal Plasticity; Neurons; Neuropeptides; Proteasome Endopeptidase Complex; Synapses; Synaptophysin

2001
Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells.
    Biochemical and biophysical research communications, 2002, Jan-11, Volume: 290, Issue:1

    Topics: Acetylcysteine; Blotting, Western; Caco-2 Cells; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Dose-Response Relationship, Drug; Enterocytes; Enzyme Activation; Epithelial Cells; Heat-Shock Proteins; Hot Temperature; HSP72 Heat-Shock Proteins; Humans; Intestinal Mucosa; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Isoforms; Quercetin; Temperature; Time Factors; Transcription Factors

2002
Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.
    Biochemical and biophysical research communications, 2002, Jan-25, Volume: 290, Issue:3

    Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Nuclear Proteins; Peptide Hydrolases; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Retinoblastoma-Like Protein p130

2002
Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.
    Cellular and molecular neurobiology, 2001, Volume: 21, Issue:5

    Topics: Acetylcysteine; Animals; Cell Differentiation; Cyclic AMP; Cyclin B; Cyclin B1; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, myc; Green Fluorescent Proteins; Humans; Leupeptins; Luminescent Proteins; Mice; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Retroviridae; Transcription, Genetic; Transfection; Tumor Cells, Cultured

2001
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies.
    The Journal of cell biology, 2002, Mar-04, Volume: 156, Issue:5

    Topics: Acetylcysteine; Ammonium Chloride; Animals; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasmic Vesicles; Endocytosis; Endopeptidases; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Intracellular Membranes; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Transforming Growth Factor alpha; Ubiquitin-Protein Ligases; Ubiquitins

2002
Role of ATP in influenza virus budding.
    Virology, 2001, Nov-25, Volume: 290, Issue:2

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cell Line; Cell Membrane Permeability; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Enzyme Inhibitors; Humans; Indoles; Influenza A virus; Kinetics; Leupeptins; Lysophosphatidylcholines; Multienzyme Complexes; Oligopeptides; Ouabain; Proteasome Endopeptidase Complex; Sodium-Potassium-Exchanging ATPase; Sulfones; Thapsigargin; Viscosity

2001
Notch receptor cleavage depends on but is not directly executed by presenilins.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Mar-19, Volume: 99, Issue:6

    Topics: Acetylcysteine; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Extracts; Cell Line; Detergents; Endopeptidases; Fluorometry; Humans; Leupeptins; Membrane Proteins; Mice; Mutation; Presenilin-1; Presenilin-2; Protease Inhibitors; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Notch; Signal Transduction; Solubility

2002
Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:4

    Topics: Acetylcysteine; Caco-2 Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enterocytes; Epithelial Cells; Gene Expression; Heat Shock Transcription Factors; Heat-Shock Proteins; Heat-Shock Response; HSP72 Heat-Shock Proteins; Humans; Interleukin-6; Intestinal Mucosa; Leupeptins; Multienzyme Complexes; NF-kappa B; Proteasome Endopeptidase Complex; RNA, Messenger; Transcription Factors; Transcriptional Activation

2002
6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease.
    Cellular and molecular neurobiology, 2001, Volume: 21, Issue:6

    Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Leupeptins; Lewy Bodies; Methionine; Models, Neurological; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Substantia Nigra; Sulfur Radioisotopes; Sympatholytics; Ubiquitins

2001
Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes.
    Infection and immunity, 2002, Volume: 70, Issue:7

    Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA, Protozoan; Female; Glycoproteins; Kinetics; Leishmania mexicana; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Donors; Proteasome Endopeptidase Complex; Sodium Nitrite; Time Factors

2002
The effect of proteasome inhibitors on mammalian erythroid terminal differentiation.
    Experimental hematology, 2002, Volume: 30, Issue:7

    Topics: Acetylcysteine; Animals; Blotting, Western; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Viral; Cysteine Endopeptidases; Cytoplasm; Erythroid Precursor Cells; Erythropoiesis; Friend murine leukemia virus; Leupeptins; Mice; Multienzyme Complexes; Nuclear Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Reticulocytes; Ubiquitin

2002
Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation.
    American journal of respiratory cell and molecular biology, 2002, Volume: 27, Issue:2

    Topics: Acetylcysteine; Cell Line; Chemotaxis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Epithelial Cells; Genes, Reporter; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neutrophils; NF-kappa B; Proteasome Endopeptidase Complex; ras Proteins; Reactive Oxygen Species; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured

2002
Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 283, Issue:3

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Hepatocytes; HSP70 Heat-Shock Proteins; Hydrocortisone; Leupeptins; Multienzyme Complexes; Oncorhynchus mykiss; Proteasome Endopeptidase Complex; Receptors, Glucocorticoid; Sulfur Radioisotopes

2002
Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.
    Biochemical and biophysical research communications, 2002, Sep-06, Volume: 296, Issue:5

    Topics: 3T3 Cells; Acetylcysteine; Adipocytes; Animals; Biological Transport; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glucose; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Leupeptins; Mice; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction

2002
Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.
    FEBS letters, 2002, Aug-28, Volume: 526, Issue:1-3

    Topics: Acetylcysteine; Antioxidants; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Genes, Reporter; Humans; Interleukin-8; Leupeptins; Luciferases; Multienzyme Complexes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Recombinant Proteins; Transcription Factor AP-1; Transfection

2002
Proteasome inhibitors induce apoptosis in growth hormone- and prolactin-secreting rat pituitary tumor cells.
    The Journal of endocrinology, 2002, Volume: 174, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspases; Cells, Cultured; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Female; Growth Hormone; In Situ Nick-End Labeling; Leupeptins; Multienzyme Complexes; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactinoma; Proteasome Endopeptidase Complex; Rats; Tumor Cells, Cultured

2002
Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.
    Archives of biochemistry and biophysics, 2002, Sep-15, Volume: 405, Issue:2

    Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glucuronosyltransferase; Glycoproteins; Half-Life; Hepatocytes; Leupeptins; Male; Monosaccharide Transport Proteins; Multienzyme Complexes; Mutation; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Gunn; Rats, Wistar; RNA, Messenger; Subcellular Fractions

2002
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
    Science (New York, N.Y.), 2002, Nov-29, Volume: 298, Issue:5599

    Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosol; Endopeptidase K; Endoplasmic Reticulum; Leupeptins; Mice; Models, Biological; Multienzyme Complexes; Neurons; Oligopeptides; Prions; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Transport; PrPSc Proteins; Solubility; Transfection; Tumor Cells, Cultured

2002
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2002, Volume: 22, Issue:9

    Topics: Acetylcysteine; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Doxorubicin; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oxidative Stress; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Reactive Oxygen Species

2002
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
    Science (New York, N.Y.), 2002, Oct-25, Volume: 298, Issue:5594

    Topics: Acetylcysteine; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Blood; Cell Line; Cycloheximide; Cysteine Endopeptidases; Feedback, Physiological; Gene Expression Regulation; Glycosyltransferases; Half-Life; Homeodomain Proteins; Leupeptins; Mesoderm; Mice; Multienzyme Complexes; PC12 Cells; Periodicity; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Transcription Factor HES-1; Transcription, Genetic; Transfection; Ubiquitin

2002
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.
    Blood, 2003, Mar-01, Volume: 101, Issue:5

    Topics: Acetylcysteine; Acute Disease; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Cell Transformation, Viral; Enzyme Activation; Gene Expression Regulation, Viral; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 8, Human; Humans; I-kappa B Proteins; Leukemia, Myeloid; Leupeptins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; NF-kappa B; Oxides; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Recombinant Proteins; Rhadinovirus; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Proteins

2003
Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.
    Journal of neurochemistry, 2002, Volume: 83, Issue:2

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Blotting, Western; Carrier Proteins; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Humans; Inclusion Bodies; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Macromolecular Substances; Mice; Multienzyme Complexes; Nerve Tissue Proteins; Neuroblastoma; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Synucleins; Transfection; Ubiquitin

2002
Sustained activation of N-WASP through phosphorylation is essential for neurite extension.
    Developmental cell, 2002, Volume: 3, Issue:5

    Topics: Acetylcysteine; Actin-Related Protein 2; Actin-Related Protein 3; Amino Acid Sequence; Animals; cdc42 GTP-Binding Protein; Cell Line; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Female; Leupeptins; Mice; Mice, Inbred ICR; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Neurites; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Spodoptera; src-Family Kinases; Wiskott-Aldrich Syndrome Protein, Neuronal

2002
Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.
    Molecular and cellular biology, 2003, Volume: 23, Issue:2

    Topics: Acetylcysteine; Blotting, Northern; Blotting, Western; BRCA1 Protein; Cell Cycle; Cell Division; Cell Survival; Collagen; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Combinations; Enzyme Inhibitors; Extracellular Matrix; Genetic Vectors; Germ-Line Mutation; Humans; Immunoblotting; Laminin; Leupeptins; MAP Kinase Signaling System; Neuregulin-1; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Polylysine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured

2003
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
    Archives of biochemistry and biophysics, 2003, Feb-01, Volume: 410, Issue:1

    Topics: Acetylcysteine; Benzoquinones; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Gene Expression; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Leupeptins; Ligases; Male; Molecular Chaperones; Multienzyme Complexes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Quinones; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases

2003
Early degradation of paternal mitochondria in domestic pig (Sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and MG132.
    Biology of reproduction, 2003, Volume: 68, Issue:5

    Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Fertilization in Vitro; Fluorescent Antibody Technique; In Vitro Techniques; Leupeptins; Male; Microscopy, Electron; Mitochondria; Mitosis; Multienzyme Complexes; Ovum; Pregnancy; Proteasome Endopeptidase Complex; Sperm Maturation; Spermatozoa; Swine; Ubiquitin; Zygote

2003
Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates.
    The international journal of biochemistry & cell biology, 2003, Volume: 35, Issue:5

    Topics: Acetylcysteine; Animals; Cell Line; Chromatography, Gel; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Mice; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Substrate Specificity; Ubiquitin

2003
p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.
    Oncogene, 2003, Apr-17, Volume: 22, Issue:15

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Breast; Breast Neoplasms; Carrier Proteins; Cells, Cultured; Computer Systems; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteins; Proto-Oncogene Proteins c-ets; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sequestosome-1 Protein; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Ubiquitin

2003
Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jun-01, Volume: 23, Issue:11

    Topics: Acetylcysteine; Animals; Bromodeoxyuridine; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Immunohistochemistry; Leupeptins; Macromolecular Substances; Oligodendroglia; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Signal Transduction

2003
Imaging 26S proteasome activity and inhibition in living mice.
    Nature medicine, 2003, Volume: 9, Issue:7

    Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Coleoptera; Cysteine Proteinase Inhibitors; Genes, Reporter; HeLa Cells; Humans; Kinetics; Leupeptins; Luciferases; Luminescent Measurements; Male; Mice; Mice, Nude; Molecular Biology; Peptide Hydrolases; Proteasome Endopeptidase Complex; Pyrazines; Transfection; Ubiquitin; Xenograft Model Antitumor Assays

2003
Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb.
    Cell death and differentiation, 2003, Volume: 10, Issue:8

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Cytochromes c; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leupeptins; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Multienzyme Complexes; Osteosarcoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Retinoblastoma Protein; Time Factors; Transfection; Tumor Suppressor Protein p53

2003
The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Aug-01, Volume: 171, Issue:3

    Topics: Acetylcysteine; Acute-Phase Proteins; Animals; Carrier Proteins; Cell Line; Chymotrypsin; Cross-Linking Reagents; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Escherichia coli; Glutamate Synthase; Leupeptins; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Membrane Glycoproteins; Membrane Proteins; Methanosarcina; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Shock, Septic; Signal Transduction; Tritium

2003
BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells.
    Oncogene, 2003, Jul-17, Volume: 22, Issue:29

    Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Doxycycline; Etoposide; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Lymphoma, B-Cell; Membrane Potentials; Mitochondria; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-6; Reactive Oxygen Species; Transcription Factors; Tumor Cells, Cultured

2003
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.
    Oncogene, 2003, Jul-31, Volume: 22, Issue:31

    Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Diamines; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Megakaryoblastic, Acute; Leupeptins; Lysine; Multienzyme Complexes; Oligodeoxyribonucleotides, Antisense; Peptide Initiation Factors; Peptide Mapping; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteomics; RNA-Binding Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin

2003
A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.
    Molecular and cellular biology, 2003, Volume: 23, Issue:19

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; Cell Line; Cysteine Proteinase Inhibitors; Deferoxamine; Humans; Iron; Iron Chelating Agents; Iron Regulatory Protein 1; Leupeptins; Mice; Molecular Sequence Data; Mutation; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine

2003
The mechanism of alphaB-crystallin gene expression by proteasome inhibition.
    Biochemical and biophysical research communications, 2003, Nov-07, Volume: 311, Issue:1

    Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Heat-Shock Response; Leupeptins; Multienzyme Complexes; Myocytes, Cardiac; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Rats

2003
Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes.
    Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:5

    Topics: Acetylcysteine; Apoptosis; Cell Death; Cell Line, Tumor; Chemotaxis, Leukocyte; Cysteine Proteinase Inhibitors; DNA; DNA Fragmentation; Enzyme Activation; Fetus; Hepatocytes; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Peptide Hydrolases; Proteasome Endopeptidase Complex; RNA, Messenger; Transcription Factor AP-1; Up-Regulation

2003
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
    Cytokine, 2003, Nov-07, Volume: 24, Issue:3

    Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins

2003
Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.
    Arteriosclerosis, thrombosis, and vascular biology, 2004, Volume: 24, Issue:1

    Topics: Acetylcysteine; Animals; Apolipoproteins B; Cells, Cultured; Cysteine Endopeptidases; Diabetes Mellitus; Disease Models, Animal; Gerbillinae; Hepatocytes; Hypercholesterolemia; Hyperinsulinism; Hypertriglyceridemia; Insulin; Insulin Resistance; Leupeptins; Lipoproteins, VLDL; Liver; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex

2004
The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells.
    Traffic (Copenhagen, Denmark), 2003, Volume: 4, Issue:12

    Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Cell Line; Cell Nucleus; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Flow Cytometry; Genes, Dominant; Green Fluorescent Proteins; Hemagglutinins; Hydrogen-Ion Concentration; Leupeptins; Luminescent Proteins; Microscopy, Fluorescence; Mink; Orthomyxoviridae; Plasmids; Protein Transport; Receptor, IGF Type 2; Retroviridae; Saccharomyces cerevisiae Proteins; Time Factors; Transfection; Ubiquitin; Vesicular stomatitis Indiana virus; Virus Replication

2003
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
    Neuron, 2003, Oct-30, Volume: 40, Issue:3

    Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Calcium; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Disks Large Homolog 4 Protein; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Endocytosis; Epitopes; Excitatory Amino Acid Agonists; Hippocampus; Humans; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Membrane Potentials; Membrane Proteins; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Neural Inhibition; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Long-Evans; Receptors, AMPA; Synapses; Synapsins; Tacrolimus; Time Factors; Transfection; Ubiquitin

2003
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
    The Journal of biological chemistry, 2004, Mar-12, Volume: 279, Issue:11

    Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; alpha-Synuclein; Animals; Brain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Herbicides; Immunoblotting; Immunohistochemistry; Ions; L-Lactate Dehydrogenase; Leupeptins; Male; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Phosphorylation; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Rotenone; Synucleins; Time Factors; Ubiquitin

2004
Interferon-gamma induces apoptosis of lens alphaTN4-1 cells and proteasome inhibition has an antiapoptotic effect.
    Investigative ophthalmology & visual science, 2004, Volume: 45, Issue:1

    Topics: Acetylcysteine; Animals; Annexin A5; Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoprotection; DNA-Binding Proteins; Epithelial Cells; Interferon Regulatory Factor-1; Interferon Regulatory Factors; Interferon-gamma; Lens, Crystalline; Leupeptins; Mice; Multienzyme Complexes; Phosphoproteins; Proteasome Endopeptidase Complex; Recombinant Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Up-Regulation

2004
Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.
    Cancer letters, 2004, Feb-10, Volume: 204, Issue:1

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcysteine; Adenylyl Cyclase Inhibitors; Animals; Cell Differentiation; Cell Survival; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Leupeptins; Mice; Multienzyme Complexes; Neuroblastoma; Phosphodiesterase Inhibitors; Proteasome Endopeptidase Complex; Tumor Cells, Cultured

2004
[Effect of EGF on ubiquitination and proteasome-dependent degradation of phospholipase C gamma1 in A431 cells].
    Tsitologiia, 2003, Volume: 45, Issue:10

    Topics: Acetylcysteine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; Epithelial Cells; Humans; Leupeptins; Multienzyme Complexes; Phospholipase C gamma; Proteasome Endopeptidase Complex; Type C Phospholipases; Ubiquitins

2003
Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.
    Journal of lipid research, 2004, Volume: 45, Issue:6

    Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Endoplasmic Reticulum; Humans; Leupeptins; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Transport; Receptors, LDL

2004
Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors.
    International journal of oncology, 2004, Volume: 24, Issue:4

    Topics: Acetylcysteine; Apoptosis; Butyrates; Caspases; Cell Division; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Therapy, Combination; G2 Phase; Humans; Leupeptins; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins

2004
Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation.
    The Journal of reproduction and development, 2004, Volume: 50, Issue:2

    Topics: Acetylcysteine; Adult; Antioxidants; Cells, Cultured; Cyclooxygenase 2; Cysteine Endopeptidases; Dinoprost; Endometrium; Enzyme Activation; Estradiol; Female; Free Radicals; Humans; Isoenzymes; Leupeptins; Medroxyprogesterone Acetate; Membrane Proteins; Menstruation; Multienzyme Complexes; NF-kappa B; Ovary; Oxygen; Progesterone; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Steroids; Stromal Cells; Superoxide Dismutase; Superoxides; Time Factors

2004
Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells.
    Glia, 2004, Volume: 47, Issue:1

    Topics: Acetylcysteine; Astrocytes; Biphenyl Compounds; Cells, Cultured; Chemokines; Chloroquine; Dose-Response Relationship, Drug; Encephalitis; Humans; Inflammation Mediators; Leupeptins; NF-kappa B; Onium Compounds; Reaction Time; Reactive Oxygen Species; RNA, Messenger; Tosylphenylalanyl Chloromethyl Ketone

2004
Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.
    Biochemical and biophysical research communications, 2004, Jun-11, Volume: 318, Issue:4

    Topics: Acetylcysteine; Antioxidants; Cell Cycle Proteins; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; Glutathione; Humans; Leupeptins; Multienzyme Complexes; Osteosarcoma; Transcription Factors; Transcription, Genetic; Transfection

2004
Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-23, Volume: 24, Issue:25

    Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Apoptosis; Brain; Cells, Cultured; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Inclusion Bodies; Leupeptins; Microtubules; Oligodendroglia; Oxidative Stress; Phosphorylation; Proteasome Inhibitors; Rats; Rats, Wistar; RNA, Messenger; tau Proteins; Ubiquitin

2004
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:12

    Topics: Acetylcysteine; Adenosine Triphosphate; Aldehydes; alpha-Crystallin B Chain; Cell-Free System; Cells, Cultured; Epithelial Cells; Humans; Lens, Crystalline; Leupeptins; Lysosomes; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitin

2004
Proteasomal interference prevents zona pellucida penetration and fertilization in mammals.
    Biology of reproduction, 2004, Volume: 71, Issue:5

    Topics: Acetylcysteine; Acrosome; Acrosome Reaction; Animals; Exocytosis; Female; Fertilization; Fertilization in Vitro; Immune Sera; Leupeptins; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sperm-Ovum Interactions; Spermatozoa; Swine; Ubiquitin; Zona Pellucida

2004
Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents.
    Biochemical pharmacology, 2004, Aug-15, Volume: 68, Issue:4

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Small Cell; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA Damage; Drug Interactions; Enzyme Activation; Glutathione; Humans; Leupeptins; Membrane Potentials; Mitochondria; Oxidation-Reduction; Tumor Cells, Cultured

2004
Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.
    BMC pharmacology, 2004, Aug-05, Volume: 4

    Topics: Acetylcysteine; Animals; Arachidonic Acid; Breast Neoplasms; Cell Line; Cell Line, Tumor; HT29 Cells; Humans; Leupeptins; Liver; Neuroglia; Oligopeptides; Proteasome Inhibitors; Rats

2004
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.
    The Journal of biological chemistry, 2004, Nov-19, Volume: 279, Issue:47

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcysteine; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Immunoprecipitation; Leupeptins; Luciferases; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Nuclear Receptor Coactivator 2; Protease Inhibitors; Proteasome Endopeptidase Complex; Temperature; Thionucleotides; Time Factors; Transcriptional Activation; Transfection; Ubiquitin

2004
Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
    International journal of oncology, 2004, Volume: 25, Issue:5

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lung Neoplasms; Membrane Potentials; Mitochondria; Proteasome Endopeptidase Complex; Purines; Roscovitine; Signal Transduction; Tumor Cells, Cultured

2004
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
    Blood, 2005, Apr-15, Volume: 105, Issue:8

    Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspases; Cell Survival; Complement Membrane Attack Complex; Complement System Proteins; Cysteine Proteinase Inhibitors; Cytochromes c; Gene Expression; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Leupeptins; Lymphocytes; Mitochondria; Mitochondrial Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA Interference

2005
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
    Endocrinology, 2005, Volume: 146, Issue:4

    Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Insulinoma; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Pancreatic Neoplasms; Proteasome Inhibitors; Rats; Signal Transduction; Tumor Suppressor Protein p53

2005
Growth-associated protein-43 is degraded via the ubiquitin-proteasome system.
    Journal of neuroscience research, 2005, Mar-01, Volume: 79, Issue:5

    Topics: Acetylcysteine; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; GAP-43 Protein; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Immunohistochemistry; Immunoprecipitation; Leupeptins; Male; Mice; Mutagenesis; Neurons; NIH 3T3 Cells; Pregnancy; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Transfection; Ubiquitin

2005
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
    The Journal of biological chemistry, 2005, May-13, Volume: 280, Issue:19

    Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adenoviridae; Adipocytes; Animals; Cell Line; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytoplasm; Down-Regulation; Fibroblasts; Growth Hormone; Humans; Immunoblotting; Immunoprecipitation; Kinetics; Leupeptins; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Microscopy, Confocal; Models, Biological; Plasmids; Presenilin-1; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Structure, Tertiary; Receptors, Somatotropin; Recombinant Proteins; Signal Transduction; Time Factors

2005
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.
    The Journal of biological chemistry, 2005, May-13, Volume: 280, Issue:19

    Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Leupeptins; Long QT Syndrome; Mutation; Potassium Channels; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleases; Subcellular Fractions; Time Factors; Transfection; Ubiquitin

2005
Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration?
    Journal of pharmacological sciences, 2005, Volume: 97, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Lewy Bodies; Neurotoxins; Oxidopamine; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protective Agents; Rats; Substantia Nigra

2005
Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.
    The Journal of biological chemistry, 2005, Jul-01, Volume: 280, Issue:26

    Topics: Acetylcysteine; Animals; Biomarkers, Tumor; Blotting, Western; Cysteine; DNA-Binding Proteins; DNA, Complementary; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; Glutathione S-Transferase pi; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lactones; Leupeptins; Luciferases; Mice; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Time Factors; Trans-Activators; Transfection; Up-Regulation

2005
[Inhibiting expression of human telomerase reverse transcriptase promotes degradation of survivin protein].
    Ai zheng = Aizheng = Chinese journal of cancer, 2005, Volume: 24, Issue:5

    Topics: Acetylcysteine; Cell Proliferation; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Leupeptins; Microtubule-Associated Proteins; Neoplasm Proteins; Oligonucleotides, Antisense; RNA, Messenger; Survivin; Telomerase

2005
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
    Genes to cells : devoted to molecular & cellular mechanisms, 2005, Volume: 10, Issue:7

    Topics: Acetylcysteine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Deletion; Gene Expression Regulation; Half-Life; Humans; Leukemia, Experimental; Leupeptins; Mice; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Ubiquitins; Ultraviolet Rays

2005
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.
    Journal of neurochemistry, 2005, Volume: 94, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Gene Expression; Gene Expression Profiling; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Molecular Chaperones; Muscle Proteins; Neurons; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Transcription, Genetic; Transfection; Up-Regulation

2005
Inhibition of the proteasome strongly affects cadmium stimulated laccase activity in Trametes versicolor.
    Biochimie, 2005, Volume: 87, Issue:8

    Topics: Acetylcysteine; Cadmium; Chloroquine; Dose-Response Relationship, Drug; Fungal Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Laccase; Leupeptins; Mycelium; Proteasome Endopeptidase Complex; Proteasome Inhibitors

2005
Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors.
    Microbiology and immunology, 2005, Volume: 49, Issue:9

    Topics: Acetylcysteine; Animals; Cell Line; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; HN Protein; Influenza A virus; Leupeptins; Macaca mulatta; Macrophages; Orthomyxoviridae; Paramyxoviridae; Proteasome Inhibitors; Rhabdoviridae; Sendai virus; Vesicular stomatitis Indiana virus; Viral Fusion Proteins; Viral Matrix Proteins; Virus Assembly; Virus Replication

2005
UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis.
    Journal of pineal research, 2005, Volume: 39, Issue:4

    Topics: Acetylcysteine; Animals; Arylalkylamine N-Acetyltransferase; Bucladesine; Chickens; Colforsin; Cyclic AMP; Dark Adaptation; Leupeptins; Male; Oligopeptides; Organ Culture Techniques; Pineal Gland; Proteasome Endopeptidase Complex; Time Factors; Ultraviolet Rays

2005
Oxidative stress response results in increased p21WAF1/CIP1 degradation in cystic fibrosis lung epithelial cells.
    Free radical biology & medicine, 2006, Jan-01, Volume: 40, Issue:1

    Topics: Acetylcysteine; Annexin A5; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cysteine Proteinase Inhibitors; Cystic Fibrosis; Epithelial Cells; Humans; Hyperoxia; Leupeptins; Lung; Oxidative Stress; Oxygen; Reactive Oxygen Species; S Phase

2006
Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.
    Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:12

    Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; I-kappa B Kinase; Leupeptins; Male; NF-kappa B; Prostatic Neoplasms; Proteasome Inhibitors; Tumor Cells, Cultured

2005
Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.
    Experimental cell research, 2006, Feb-15, Volume: 312, Issue:4

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antigens, Nuclear; Apoptosis; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Doxorubicin; Gene Expression; HeLa Cells; Humans; Ku Autoantigen; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Signal Transduction; Staurosporine; Ubiquitin; Ubiquitin-Protein Ligase Complexes

2006
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation

2006
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.
    Molecular cancer, 2006, Feb-20, Volume: 5

    Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Cytoplasm; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Karyopherins; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA Interference; Transfection; Ubiquitin

2006
Role of the proteasome in TGF-beta signaling in lens epithelial cells.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:5

    Topics: Acetylcysteine; Actins; Annexins; Blotting, Western; Cataract; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Fibronectins; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutamate-Cysteine Ligase; Humans; Intracellular Signaling Peptides and Proteins; Lens, Crystalline; Leupeptins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transcriptional Activation; Transforming Growth Factor beta

2006
Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.
    Oncogene, 2006, Oct-12, Volume: 25, Issue:47

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Chromosome Breakage; Cisplatin; Comet Assay; DNA Damage; Doxorubicin; Etoposide; Gamma Rays; Gene Expression Regulation; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Interleukin-6; KB Cells; Leupeptins; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Proteasome Inhibitors; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sulfones; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ultraviolet Rays

2006
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:9

    Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2006
Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:1

    Topics: Acetylcysteine; Base Sequence; Cell Line; Cysteine Proteinase Inhibitors; Dexamethasone; DNA-Binding Proteins; Epithelial Cells; Gene Expression; Humans; Leupeptins; Lung; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein C; RNA, Messenger; Transcription Factors

2007
Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.
    Toxicology and applied pharmacology, 2006, Dec-15, Volume: 217, Issue:3

    Topics: Acetylcysteine; Animals; Arsenites; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Hepatocytes; Leupeptins; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Inbred F344; RNA, Messenger

2006
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.
    Biochemical and biophysical research communications, 2007, Feb-16, Volume: 353, Issue:3

    Topics: Acetylcysteine; Calpain; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cell Death; Cell Line, Tumor; Delta Catenin; Dipeptides; Humans; Ischemia; Leupeptins; Neuroblastoma; Phosphoproteins

2007
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.
    Molecular and cellular biology, 2007, Volume: 27, Issue:7

    Topics: Acetylcysteine; Carbon-Sulfur Lyases; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Humans; Iron; Iron Regulatory Protein 1; Leupeptins; Metabolic Networks and Pathways; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Transcriptional Activation; Ubiquitin

2007
Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.
    Human molecular genetics, 2007, Apr-01, Volume: 16, Issue:7

    Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Cell Line, Tumor; Centrosome; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Inclusion Bodies; Lafora Disease; Leupeptins; Microscopy, Fluorescence; Proteasome Endopeptidase Complex; Protein Binding; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Recombinant Fusion Proteins; Transfection; Tubulin; Ubiquitin; Ubiquitin-Protein Ligases

2007
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132.
    Journal of neurochemistry, 2007, Volume: 102, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Leupeptins; Mesencephalon; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Substantia Nigra

2007
Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model.
    Cellular microbiology, 2007, Volume: 9, Issue:10

    Topics: Acetylcysteine; Bacterial Proteins; Chlamydia Infections; Chlamydia trachomatis; Gene Library; HeLa Cells; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Interaction Mapping; Transcription Factors; Yersinia

2007
Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.
    Journal of neurochemistry, 2007, Volume: 101, Issue:6

    Topics: Acetylcysteine; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; CHO Cells; Cricetinae; Cricetulus; Fibroblasts; Humans; Leupeptins; Mutation, Missense; Proteasome Inhibitors; Subcellular Fractions

2007
Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:1

    Topics: Acetylcysteine; Apoptosis; Barrett Esophagus; Carcinoma, Squamous Cell; Cell Line, Tumor; Cells, Cultured; Chenodeoxycholic Acid; Cyclooxygenase 2; Deoxycholic Acid; DNA-Binding Proteins; Down-Regulation; Doxorubicin; Esophageal Neoplasms; Esophagus; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Leupeptins; Proteasome Inhibitors; Taurochenodeoxycholic Acid; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins

2007
Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors.
    Virus genes, 2007, Volume: 35, Issue:3

    Topics: Acetylcysteine; Animals; Antiviral Agents; Apoptosis; Cell Line; Chick Embryo; Chickens; Cytopathogenic Effect, Viral; Fibroblasts; Infectious bursal disease virus; Leupeptins; Proteasome Inhibitors; Protein Biosynthesis; RNA, Viral; Transcription, Genetic; Viral Proteins; Virus Internalization

2007
NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis.
    Biochemical pharmacology, 2007, Nov-15, Volume: 74, Issue:10

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Cysteine Proteinase Inhibitors; Epithelial Cells; Indomethacin; Leupeptins; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; RNA, Messenger; Stomach; Survivin; Ubiquitination

2007
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
    British journal of pharmacology, 2007, Volume: 152, Issue:7

    Topics: Acetylcysteine; Animals; Butyrates; Cells, Cultured; Dose-Response Relationship, Drug; Leupeptins; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenylurea Compounds; PPAR alpha; Proteasome Endopeptidase Complex; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor

2007
The proteasome and intracellular redox status: implications for apoptotic regulation in lens epithelial cells.
    Current eye research, 2007, Volume: 32, Issue:10

    Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; In Vitro Techniques; Intracellular Membranes; Lens, Crystalline; Leupeptins; Mice; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptide Hydrolases; Proteasome Endopeptidase Complex

2007
Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.
    Cancer science, 2008, Volume: 99, Issue:5

    Topics: Acetylcysteine; Boronic Acids; Caffeine; Cells, Cultured; Cisplatin; Cysteine Proteinase Inhibitors; DNA Damage; DNA Repair; DNA Replication; HeLa Cells; Humans; Leupeptins; Neoplasms; Proteasome Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays

2008
In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell.
    Toxicology in vitro : an international journal published in association with BIBRA, 2008, Volume: 22, Issue:4

    Topics: Acetylcysteine; Cell Movement; Chemokine CCL2; Chemotaxis; Clone Cells; Eosinophils; HL-60 Cells; Humans; Interleukin-8; Leupeptins; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Up-Regulation; Vehicle Emissions

2008
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
    EMBO reports, 2008, Volume: 9, Issue:6

    Topics: Acetylcysteine; Animals; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Leupeptins; NAD(P)H Dehydrogenase (Quinone); Nuclear Proteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine; Tumor Suppressor Proteins; Ultraviolet Rays

2008
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.
    Neuroscience, 2008, May-02, Volume: 153, Issue:2

    Topics: Acetylcysteine; Animals; Blotting, Western; Cysteine Proteinase Inhibitors; Fibroblast Growth Factors; Ganglia, Spinal; Green Fluorescent Proteins; Leupeptins; Ligands; Lysosomes; Neurites; PC12 Cells; Pheochromocytoma; Rats; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction

2008
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.
    Free radical biology & medicine, 2008, Aug-01, Volume: 45, Issue:3

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Antioxidants; Blotting, Western; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Mesencephalon; Methionine Sulfoxide Reductases; Mice; Neurons; Oxidation-Reduction; Oxidoreductases; Parkinson Disease; Rats; Rotenone; Uncoupling Agents; Vitamin E

2008
Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.
    Toxicological sciences : an official journal of the Society of Toxicology, 2008, Volume: 104, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Cadmium Compounds; Cell Survival; Cells, Cultured; Coculture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Leupeptins; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Spermatogonia; Ubiquitins

2008
Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.
    The Journal of biological chemistry, 2008, Aug-01, Volume: 283, Issue:31

    Topics: Acetylcysteine; Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Chloroquine; Excitatory Amino Acid Transporter 3; Humans; Leupeptins; Male; Morphine; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitin

2008
TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes.
    Experimental dermatology, 2008, Volume: 17, Issue:12

    Topics: Acetylcysteine; Androstadienes; Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Survival; Chromones; Deferoxamine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Keratinocytes; Leupeptins; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Tocopherols; Tumor Necrosis Factor-alpha; Wortmannin

2008
Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.
    Cancer biology & therapy, 2008, Volume: 7, Issue:11

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Inhibitors; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Naphthalimides; Proteasome Endopeptidase Complex; Protein Kinases; Thiophenes; Time Factors; Topoisomerase II Inhibitors; Ubiquitin

2008
Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.
    The international journal of biochemistry & cell biology, 2009, Volume: 41, Issue:3

    Topics: Acetylcysteine; Animals; Cell Differentiation; Cysteine Proteinase Inhibitors; Leupeptins; MAP Kinase Signaling System; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Rats; Receptor, trkA; Ubiquitination

2009
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.
    Endocrinology, 2009, Volume: 150, Issue:4

    Topics: 3T3-L1 Cells; Acetylcysteine; Adenoviridae; Aldosterone; Animals; Biological Transport; Blotting, Western; Cysteine Proteinase Inhibitors; Glucose; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Leupeptins; Mice; Phosphorylation; Reactive Oxygen Species; Receptor, Insulin; Signal Transduction

2009
Protective effect against Parkinson's disease-related insults through the activation of XBP1.
    Brain research, 2009, Feb-27, Volume: 1257

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dopamine; Endoplasmic Reticulum; Endoribonucleases; Humans; Leupeptins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factors; X-Box Binding Protein 1

2009
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
    Cellular signalling, 2009, Volume: 21, Issue:4

    Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzazepines; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclin D1; Fibroblasts; Glioma; Hexanones; Humans; Hydrocarbons, Chlorinated; Indoles; Leupeptins; Mice; Peptide Fragments; Proteasome Inhibitors; Purines; Recombinant Fusion Proteins; Roscovitine; Threonine

2009
Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion.
    Placenta, 2009, Volume: 30, Issue:4

    Topics: Acetylcysteine; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Embryo Implantation; Female; Humans; Hydatidiform Mole; Immunohistochemistry; In Vitro Techniques; Interleukin-1beta; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Placentation; Pregnancy; RNA Interference; Trophoblasts; Uterine Neoplasms

2009
Role of oxidative stress in ischemia-reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:2

    Topics: Acetylcysteine; Animals; Antioxidants; Calcium-Transporting ATPases; Cardiac Myosins; Catalase; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Leupeptins; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Myofibrils; Myosin Heavy Chains; Myosin Light Chains; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Ventricular Dysfunction, Left; Ventricular Pressure; Xanthine; Xanthine Oxidase

2009
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.
    Journal of lipid research, 2009, Volume: 50, Issue:9

    Topics: Acetylcysteine; Activating Transcription Factor 6; Animals; Apolipoprotein B-100; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Glucosamine; Heat-Shock Proteins; Humans; Leupeptins; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; RNA; Signal Transduction; Time Factors

2009
Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.
    Journal of neurotrauma, 2009, Volume: 26, Issue:5

    Topics: Acetylcysteine; Animals; Axons; Axotomy; Cells, Cultured; Cysteine Proteinase Inhibitors; Immunohistochemistry; Leupeptins; Neurofilament Proteins; Neurons; Phosphorylation; Physical Stimulation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Ubiquitin; Ubiquitination

2009
Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells.
    American journal of respiratory cell and molecular biology, 2010, Volume: 42, Issue:6

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Cell Line; Cysteine Proteinase Inhibitors; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Glucocorticoids; Humans; Hydrogen Peroxide; Interferon Regulatory Factor-3; Interleukin-8; Leupeptins; Oxidants; Oxidative Stress; Poly I-C; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Respiratory Mucosa; RNA Interference; RNA, Double-Stranded; Time Factors; Toll-Like Receptor 3; Transcription Factor RelA; Up-Regulation

2010
Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.
    Cell stress & chaperones, 2010, Volume: 15, Issue:3

    Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Heat Shock Transcription Factors; HSP30 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Proteasome Inhibitors; Temperature; Transcription Factors; Xenopus laevis

2010
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
    Biochemical and biophysical research communications, 2010, Jan-01, Volume: 391, Issue:1

    Topics: Acetylcysteine; Apoptosis; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leupeptins; Lysosomes; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Serine-Threonine Kinases

2010
The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.
    Journal of pharmacological sciences, 2009, Volume: 111, Issue:4

    Topics: Acetylcysteine; Animals; Binding Sites; Brefeldin A; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylation; Leupeptins; Membrane Transport Modulators; Protein Structure, Tertiary; Protein Transport; Quinones; Sequence Deletion; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sesquiterpenes; Structure-Activity Relationship; Transfection

2009
Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells.
    Journal of biochemistry, 2010, Volume: 147, Issue:5

    Topics: Acetylcysteine; Animals; Cells, Cultured; Curcumin; Cyclooxygenase 2; Free Radical Scavengers; Gene Expression Regulation; Isoquinolines; Leupeptins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Piperidines; Poly Adenosine Diphosphate Ribose; Pyrrolidines; Rabbits; Stress, Mechanical; Structure-Activity Relationship; Synovial Membrane; Thiocarbamates

2010
Reactive oxygen species and glutathione level changes by a proteasome inhibitor, MG132, partially affect calf pulmonary arterial endothelial cell death.
    Drug and chemical toxicology, 2010, Volume: 33, Issue:4

    Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cattle; Cell Culture Techniques; Cell Death; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Glutathione; Humans; Leupeptins; Membrane Potential, Mitochondrial; Proteasome Inhibitors; Pulmonary Artery; Reactive Oxygen Species

2010
The changes of reactive oxygen species and glutathione by MG132, a proteasome inhibitor affect As4.1 juxtaglomerular cell growth and death.
    Chemico-biological interactions, 2010, Mar-30, Volume: 184, Issue:3

    Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspase 8; Cell Line, Tumor; Ditiocarb; Enzyme Inhibitors; G1 Phase; Glutathione; Juxtaglomerular Apparatus; Leupeptins; Membrane Potential, Mitochondrial; Mice; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species

2010
The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.
    International journal of molecular medicine, 2010, Volume: 25, Issue:4

    Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Leupeptins; Lung Neoplasms; Membrane Potential, Mitochondrial; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species

2010
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.
    Journal of periodontal research, 2010, Volume: 45, Issue:4

    Topics: Acetylcysteine; Apoptosis; Cell Culture Techniques; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Fibronectins; Humans; Leupeptins; Mutation; Peptide Fragments; Periodontal Ligament; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53; Ubiquitin

2010
Attenuation of MG132-induced HeLa cell death by N-acetyl cysteine via reducing reactive oxygen species and preventing glutathione depletion.
    Anticancer research, 2010, Volume: 30, Issue:6

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; Glutathione; HeLa Cells; Humans; Leupeptins; Membrane Potential, Mitochondrial; Proteasome Inhibitors; Reactive Oxygen Species

2010
Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase.
    Biochimie, 2010, Volume: 92, Issue:12

    Topics: Acetylcysteine; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Isocitrate Dehydrogenase; Leupeptins; Mitochondrial Proteins; Phosphatidylinositol 3-Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sp1 Transcription Factor

2010
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.
    Cell biology and toxicology, 2011, Volume: 27, Issue:2

    Topics: Acetylcysteine; Animals; Biological Assay; Boronic Acids; Bortezomib; Cell Extracts; Cells, Cultured; Chymotrypsin; High-Throughput Screening Assays; Inhibitory Concentration 50; Leupeptins; Mice; Models, Biological; Oligopeptides; Ornithine Decarboxylase; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Time Factors

2011
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
    Oncogene, 2011, Feb-17, Volume: 30, Issue:7

    Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin

2011
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.
    The Journal of biological chemistry, 2010, Dec-24, Volume: 285, Issue:52

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Line, Tumor; Cerebral Cortex; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lewy Bodies; Neurons; Okadaic Acid; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rabbits; Ubiquitin

2010
Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.
    FEBS letters, 2011, Jan-03, Volume: 585, Issue:1

    Topics: Acetylcysteine; Aminopeptidases; Blotting, Western; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dose-Response Relationship, Drug; Drug Synergism; Enterovirus B, Human; Enzyme Inhibitors; HeLa Cells; Host-Pathogen Interactions; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine Endopeptidases; Virus Replication

2011
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.
    Nephrology (Carlton, Vic.), 2011, Volume: 16, Issue:1

    Topics: Acetylcysteine; Actins; Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Kidney Diseases; Leupeptins; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Ureteral Obstruction

2011
Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication.
    Journal of virology, 2011, Volume: 85, Issue:6

    Topics: Acetylcysteine; Dengue Virus; Gene Knockdown Techniques; HeLa Cells; Humans; Leupeptins; Listeria monocytogenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Ubiquitin; Ubiquitin-Protein Ligases; Virus Internalization; Virus Replication; West Nile virus; Yellow fever virus

2011
Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.
    The Journal of biological chemistry, 2011, Mar-11, Volume: 286, Issue:10

    Topics: Acetylcysteine; Analgesics, Opioid; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Leupeptins; Naloxone; Narcotic Antagonists; Pertussis Toxin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-2; Receptors, Bradykinin; Receptors, Opioid, delta; Receptors, Opioid, mu; RGS Proteins; Signal Transduction; Time Factors; Ubiquitination

2011
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.
    The Journal of biological chemistry, 2011, Mar-18, Volume: 286, Issue:11

    Topics: Acetylcysteine; Amino Acid Substitution; Animals; Calcium Channels, N-Type; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Gene Expression Regulation; Leupeptins; Mutation, Missense; Nerve Tissue Proteins; Neurites; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Rats

2011
Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
    The Journal of biological chemistry, 2011, Apr-01, Volume: 286, Issue:13

    Topics: Acetylcysteine; Animals; Blast Crisis; Carrier Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine Proteinase Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Leukemic; GTP-Binding Proteins; HL-60 Cells; Humans; Hydrogen Peroxide; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Lymphoma; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Neoplasms, Experimental; Nuclear Proteins; Oxidants; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Multimerization; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins

2011
Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.
    Journal of cellular physiology, 2011, Volume: 226, Issue:7

    Topics: Acetylcysteine; Actins; Animals; Binding Sites; Carotid Artery Injuries; Cells, Cultured; Chromatin Immunoprecipitation; Collagen; Cysteine Proteinase Inhibitors; Disease Models, Animal; DNA Polymerase II; Gels; Gene Expression Regulation; Genotype; Humans; Leupeptins; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Phosphorylation; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Serine; Serum Response Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Vasoconstriction

2011
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
    The Journal of biological chemistry, 2011, Aug-19, Volume: 286, Issue:33

    Topics: Acetylcysteine; Animals; Anthracenes; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Activation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin Receptor Substrate Proteins; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats

2011
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.
    Parasitology, 2011, Volume: 138, Issue:9

    Topics: Acetylcysteine; Cell Culture Techniques; Cloning, Molecular; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Gene Expression; Immunoprecipitation; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Leupeptins; Methionine Adenosyltransferase; Oligopeptides; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; S-Adenosylmethionine; Transfection; Ubiquitin

2011
Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.
    Biochemical and biophysical research communications, 2011, Dec-02, Volume: 415, Issue:4

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Herpesvirus 8, Human; Humans; Leupeptins; Lymphoma, Primary Effusion; NF-kappa B; Nitriles; Oligopeptides; Proteasome Inhibitors; Sulfones; Virus Replication

2011
Effects of proteasome inhibitors on the nucleolar size of porcine oocytes.
    The Journal of reproduction and development, 2012, Volume: 58, Issue:1

    Topics: Acetylcysteine; Alpha-Amanitin; Animals; Cell Nucleolus; Cysteine Proteinase Inhibitors; Dactinomycin; Female; Leupeptins; Nuclear Proteins; Oocytes; Proteasome Inhibitors; Swine

2012
Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.
    Oncology, 2011, Volume: 81 Suppl 1

    Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Doxorubicin; HEK293 Cells; Humans; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Proteasome Endopeptidase Complex; Ubiquitin

2011
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.
    Journal of cell science, 2012, Mar-01, Volume: 125, Issue:Pt 5

    Topics: Acetylcysteine; Ammonium Chloride; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Gene Knockout Techniques; HEK293 Cells; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leupeptins; Lysosomes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Presenilin-1; Presenilin-2; Proteasome Inhibitors; Proteolysis; Receptor, Notch1; Transcription, Genetic; Transcriptional Activation; Ubiquitination

2012
Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation.
    Journal of biochemistry, 2012, Volume: 151, Issue:4

    Topics: Acetylcysteine; Amino Acid Substitution; CDC2 Protein Kinase; Cell Cycle Proteins; Dual-Specificity Phosphatases; Gene Expression; HeLa Cells; Humans; Leupeptins; Okadaic Acid; Peptide Fragments; Phosphoric Monoester Hydrolases; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Ubiquitin

2012
High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.
    BMB reports, 2012, Volume: 45, Issue:5

    Topics: Acetylcysteine; Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Resistance; Embryonic Stem Cells; Gene Expression Regulation, Developmental; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Mice; Oligopeptides; Pluripotent Stem Cells; Proteasome Inhibitors

2012
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
    International journal of cancer, 2013, Feb-01, Volume: 132, Issue:3

    Topics: Acetylcysteine; Adenocarcinoma; Adenosine Triphosphate; Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chaperonins; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Mice; Mice, Nude; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Sulfhydryl Compounds

2013
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
    The Biochemical journal, 2013, Dec-01, Volume: 456, Issue:2

    Topics: Acetylcysteine; Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Glucokinase; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leupeptins; Mice; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Single-Cell Analysis; Ubiquitin; Ubiquitination

2013
N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner.
    Neuroscience, 2013, Volume: 255

    Topics: Acetylcysteine; Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Free Radical Scavengers; High-Throughput Screening Assays; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Neurons; Neuroprotective Agents; Proteasome Endopeptidase Complex; Protein Folding

2013
Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Acetylcysteine; Animals; Anthracenes; Astrocytes; Connexin 43; Down-Regulation; Gap Junctions; JNK Mitogen-Activated Protein Kinases; Leupeptins; Lipopolysaccharides; NF-kappa B; Proteasome Endopeptidase Complex; Proteolysis; Rats; Signal Transduction; Ubiquitination; Ubiquitins

2013
Enzyme enhancers for the treatment of Fabry and Pompe disease.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2015, Volume: 23, Issue:3

    Topics: 1-Deoxynojirimycin; Acetylcysteine; alpha-Galactosidase; alpha-Glucosidases; Ambroxol; Bezafibrate; Enzyme Activators; Fabry Disease; Gene Expression; Glycogen Storage Disease Type II; HEK293 Cells; Humans; Leupeptins; Lysosomes; Pioglitazone; Plasmids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Recombinant Proteins; Thiazolidinediones; Transfection

2015
Partial inhibition of the ubiquitin-proteasome system ameliorates cardiac dysfunction following ischemia-reperfusion in the presence of high glucose.
    Cardiovascular diabetology, 2015, Jul-28, Volume: 14

    Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Autophagy; Diabetic Cardiomyopathies; Hyperglycemia; Inflammation Mediators; Isolated Heart Preparation; Leupeptins; Male; Myocardial Reperfusion Injury; Myocardium; Proteasome Inhibitors; Rats, Wistar; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors

2015
The immobilization of human spermatozoa by STAT3 inhibitory compound V results from an excessive intracellular amount of reactive oxygen species.
    Andrology, 2016, Volume: 4, Issue:1

    Topics: Acetylcysteine; Acrosome Reaction; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Apoptosis; Calcium; Caspase Inhibitors; Cyclic S-Oxides; Humans; Leupeptins; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Proteasome Inhibitors; Reactive Oxygen Species; Sperm Motility; Spermatozoa; STAT3 Transcription Factor

2016
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
    Journal of immunology (Baltimore, Md. : 1950), 2016, Jan-01, Volume: 196, Issue:1

    Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Autophagy; Autophagy-Related Protein 12; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Chloroquine; Dendritic Cells; Endocytosis; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class II; Humans; Immunotherapy, Adoptive; Leupeptins; Lymphocyte Activation; Lysosomal-Associated Membrane Protein 2; Melanoma; Membrane Proteins; RNA Interference; RNA, Small Interfering; Small Ubiquitin-Related Modifier Proteins

2016
Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.
    Hippocampus, 2016, Volume: 26, Issue:8

    Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Glutathione; Hippocampus; HSP70 Heat-Shock Proteins; Leupeptins; Microtubule-Associated Proteins; Models, Neurological; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Proteasome Endopeptidase Complex; Rats, Sprague-Dawley; Stress, Physiological

2016
The effect of peptidic and non-peptidic proteasome inhibitors on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype.
    Experimental parasitology, 2016, Volume: 168

    Topics: Acanthamoeba castellanii; Acetylcysteine; Bortezomib; Brain; Cell Adhesion; Cells, Cultured; Chlorhexidine; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Genotype; Humans; Lactones; Leupeptins; Proteasome Inhibitors

2016
Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large-scale and targeted quantitative proteomics.
    Proteomics, 2017, Volume: 17, Issue:7

    Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Bortezomib; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Ontology; Heat-Shock Proteins; Humans; Interleukins; Leukocytes; Leupeptins; Molecular Sequence Annotation; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Signal Transduction; Transcription Factors; Tumor Suppressor Protein p53

2017
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
    Cell death and differentiation, 2017, Volume: 24, Issue:2

    Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases

2017
Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells.
    Redox biology, 2017, Volume: 13

    Topics: Acetylcysteine; Carrier Proteins; Caspase 10; Free Radical Scavengers; Glutathione; HCT116 Cells; HSP90 Heat-Shock Proteins; HT29 Cells; Humans; Leukemia; Leupeptins; MCF-7 Cells; Protease Inhibitors; Proteolysis; Reactive Oxygen Species

2017
    Molecular pharmacology, 2017, Volume: 92, Issue:5

    Topics: Acetylcysteine; Animals; Astrocytes; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Female; Glutathione; HSP70 Heat-Shock Proteins; Leupeptins; Male; Protein Folding; Rats; Rats, Sprague-Dawley

2017
Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells.
    The Journal of biological chemistry, 2018, 09-14, Volume: 293, Issue:37

    Topics: Acetylcysteine; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Down-Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Insulin-Secreting Cells; Insulinoma; Islet Amyloid Polypeptide; Leupeptins; Mice; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats

2018
A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses.
    Viruses, 2019, 04-23, Volume: 11, Issue:4

    Topics: Acetylcysteine; Alphavirus; Animals; Antiviral Agents; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Cytoplasm; HeLa Cells; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Vero Cells; Virus Replication

2019
The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus.
    Microbial pathogenesis, 2019, Volume: 132

    Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Ducks; Flavivirus; Gene Knockdown Techniques; Leupeptins; Poultry Diseases; Proteasome Endopeptidase Complex; RNA, Small Interfering; Transfection; Ubiquitin; Viral Envelope Proteins; Virus Internalization; Virus Replication

2019
Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus.
    Molecular neurobiology, 2019, Volume: 56, Issue:11

    Topics: Acetylcysteine; Animals; Autophagy; Cell Line, Tumor; Cell Nucleus; GPI-Linked Proteins; Humans; Leupeptins; Mice, Knockout; Models, Biological; Nerve Tissue Proteins; Neuroglia; Neurons; Prions; Promoter Regions, Genetic; Proteasome Inhibitors

2019