acetylcysteine has been researched along with leupeptins in 254 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 63 (24.80) | 18.2507 |
2000's | 144 (56.69) | 29.6817 |
2010's | 46 (18.11) | 24.3611 |
2020's | 1 (0.39) | 2.80 |
Authors | Studies |
---|---|
Goldberg, AL; Jensen, TJ; Loo, MA; Pind, S; Riordan, JR; Williams, DB | 1 |
Howley, PM; Huibregtse, JM; Maki, CG | 1 |
Goldberg, AL; Grimm, LM; Osborne, BA; Poirier, GG; Schwartz, LM | 1 |
Becherer, JD; Fernandez, PA; Irmler, M; Maki, M; Martinou, I; Martinou, JC; Quiquerez, AL; Sadoul, R; Schröter, M; Tschopp, J | 1 |
Goldberg, AL; Lee, DH | 2 |
Darnell, JE; Haspel, RL; Salditt-Georgieff, M | 1 |
Benham, A; Braud, V; Cerundolo, V; Gould, K; Macino, B; Mukherjee, S; Neefjes, J; Townsend, A | 1 |
Fujita, K; Omura, S; Silver, J | 1 |
Cresswell, P; Hammond, C; Hughes, EA | 1 |
Bush, KT; Goldberg, AL; Nigam, SK | 1 |
Roberts, BJ | 1 |
An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L | 1 |
Mellgren, RL | 2 |
Hara, K; Koide, T; Kozuki, D; Omura, S; Shirotani, H; Tokunaga, F | 1 |
Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T | 1 |
Bai, A; Forman, J | 1 |
Folco, EJ; Koren, G | 1 |
Celis, JE; Chen, HY; Davie, JR; Mimnaugh, EG; Neckers, L | 1 |
Fischer, JE; Hasselgren, PO; Hobler, SC; Monaco, J; Tiao, G | 1 |
Biber, J; Lederer, E; Murer, H; Pfister, MF; Ruf, I; Stange, G; Ziegler, U | 1 |
Hyun, WC; Mutomba, MC; To, WY; Wang, CC | 1 |
Gabai, VL; Meriin, AB; Sherman, MY; Shifrin, VI; Yaglom, J | 1 |
Antón, LC; Bacík, I; Bennink, JR; Bour, S; Cox, JH; Orlowski, M; Schubert, U; Strebel, K; Yewdell, JW | 1 |
Arenzana-Seisdedos, F; Friguet, B; Heard, JM; Maréchal, V; Schwartz, O | 1 |
Field, MC; Nesbeth, DN; Wainwright, LJ; Wilbourn, B | 1 |
Calautti, E; Di Cunto, F; Dotto, GP; Hsiao, J; Ong, L; Seth, PK; Topley, G | 1 |
Adeli, K; Gapor, A; Theriault, A; Wang, Q | 1 |
Keller, SH; Lindstrom, J; Taylor, P | 1 |
Colella, TA; Crotzer, VL; Engelhard, VH; Hunt, DF; King, GM; Luckey, CJ; Maier, BF; Marto, JA; Shabanowitz, J; Venketeswaran, S | 1 |
Bercovich, B; Ciechanover, A; Gross-Mesilaty, S; Kahana, C; Reinstein, E; Schwartz, AL; Tobias, KE | 1 |
Fang, CH; Fischer, JE; Hasselgren, PO; Hobler, S; Li, BG; Wang, JJ | 1 |
Bentley, GV; Grisanti, MS; Murray, EJ; Murray, SS | 1 |
Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
Deeg, M; Dick, TP; Groll, M; Heinemeyer, W; Huber, R; Keilholz, W; Nussbaum, AK; Rammensee, HG; Schild, H; Schirle, M; Stevanović, S; Wolf, DH | 1 |
Chrétien, S; Gisselbrecht, S; Lacombe, C; Mayeux, P; Muller, O; Varlet, P; Verdier, F; Yoshimura, A | 1 |
Levine, L | 2 |
Di Sano, F; Oliverio, S; Piacentini, M; Spinedi, A | 1 |
Adams, J; Brand, S; Conner, EM; Destree, A; Elliott, PJ; Grisham, MB; Mazzola, LM; Palombella, VJ; Parent, L; Pien, C; Wong, HL | 1 |
Kim, D; Kim, SH; Li, GC | 1 |
Guerra, B; Lanford, RE; Wang, J; White, AL | 1 |
Dennis, AP; Lonard, DM; Nawaz, Z; O'Malley, BW; Smith, CL | 1 |
Choi, YH; Henkart, PA; Hwang, SG; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, PM; Takano, E; Trepel, JB; Wu, ML | 1 |
Chen, BD; Chen, C; Lin, H; Zhang, XM | 1 |
Mulligan-Kehoe, MJ; Russo, A | 1 |
Banks, L; Mantovani, F | 1 |
Irie, S; Katagiri, K; Katagiri, T; Kawashima, S; Kinashi, T; Tanaka, K; Yokosawa, H | 1 |
Ancolio, K; Checler, F; da Costa, CA | 1 |
Coux, O; Doo, E; Goldberg, AL; Hu, Z; Liang, TJ; Zhang, Z | 1 |
Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D | 1 |
Redman, C; Xia, H | 1 |
Nigam, SK; Tsukamoto, T | 1 |
Baldin, V; Brichese, L; Chadebech, P; Valette, A; Vidal, S | 1 |
Hunter-Ensor, M; Naidoo, N; Sehgal, A; Song, W | 1 |
Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N | 1 |
Eitel, K; Hermisson, M; Wagenknecht, B; Weller, M | 1 |
Clarke, DM; Loo, TW | 1 |
Asuru, A; Boudjelal, M; Fisher, GJ; Kang, S; Li, XY; Peng, ZH; Voorhees, JJ; Xiao, JH | 1 |
Kim, D; Li, GC | 1 |
Chi, CX; Jiang, Y; Rom, WN; Tchou-Wong, KM; Yie, TA | 1 |
Biswal, SS; Datta, K; Kehrer, JP; Robertson, JD | 1 |
Koizumi, H; Mano, K; Murata, M; Ohta, K; Yamashita, N | 1 |
Guroff, G; Hashimoto, K; Katagiri, Y | 1 |
Barbato, C; Calissano, P; Canu, N; Ciotti, MT; Dus, L; Serafino, A | 1 |
Doms, RW; Lee, VM; Pijak, DS; Skovronsky, DM | 1 |
Carpino, N; Feng, J; Ihle, JN; Marine, JC; Moriggl, R; Stravopodis, D; Teglund, S; Wang, D | 1 |
Higasa, T; Kito, M; Kusunose, M; Moriyama, T; Urade, R | 1 |
Kaneda, T; Kudo, Y; Miyauchi, M; Nikai, H; Ogawa, I; Sato, S; Takata, T; Takekoshi, T; Zhao, M | 1 |
Amsterdam, A; Dantes, A; Dekel, N; Galiani, D; Josefsberg, LB | 1 |
Bergmann, C; Del Val, M; Gil-Torregrosa, BC; López, D | 1 |
Bohrn, E; Herceg, Z; Wang, ZQ; Wesierska-Gadek, J; Wurzer, G | 1 |
Einarson, MB; Fashena, SJ; Golemis, EA; Law, SF; O'Neill, GM | 1 |
An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB | 1 |
Davie, JR; Lucktong, A; Melkoumian, ZK; Moniwa, M; Strobl, JS; Zhou, Q | 1 |
French, OG; Hahn, CS; Kang, BS; Sando, JJ | 1 |
Alving, CR; Rao, M; Rothwell, SW; Wassef, NM | 1 |
Masaki, R; Ohtani-Kaneko, R; Saito, T; Yamada, K | 1 |
Malek, TR; Yu, A | 1 |
Hauptmann, S; Leclere, A; Naujokat, C; Possinger, K; Sezer, O; Zinke, H | 1 |
Groscurth, P; Hermisson, M; Krammer, PH; Liston, P; Wagenknecht, B; Weller, M | 1 |
He, CY; Roos, DS; Shaw, MK; Tilney, LG | 1 |
Chau, V; Patnaik, A; Wills, JW | 1 |
Ostrand-Rosenberg, S; Qi, L | 1 |
Furuta, K; Hanada, S; Harada, M; Kawaguchi, T; Kim, M; Kimura, R; Koga, H; Sakisaka, S; Sata, M; Suganuma, T; Sugiyama, T; Taniguchi, E; Terada, K | 1 |
Goldenberg, GJ; Lam, V; McPherson, JP; Salmena, L | 1 |
Lemoine, NR; Marani, M; McNeish, I; Tenev, T | 1 |
Dautry-Varsat, A; Lamaze, C; Rocca, A; Subtil, A | 1 |
Bence, NF; Kopito, RR; Sampat, RM | 1 |
Drahushuk, KM; Guo, X; Higgins, D; Horbinski, C; Kaplan, PL; Kim, IJ; Lein, P; Lin, Y; Wang, T | 1 |
Mezey, E; Potter, JJ; Rennie-Tankersley, L | 1 |
Morley, SJ; Pain, VM | 1 |
Almond, JB; Cain, K; Cohen, GM; Dinsdale, D; Hunter, A; Snowden, RT | 1 |
Ikemoto, H; Kitagawa, H; Matsumoto, T; Tani, E | 1 |
Ashok, BT; Kim, E; Mittelman, A; Tiwari, RK | 1 |
Burrows, J; Hale, PD; Hidvegi, T; Perlmutter, DH; Schmidt, B; Teckman, JH | 1 |
Kimura, G; Ohtsu, M; Okuda, A | 1 |
Ageta, H; Fukazawa, Y; Inokuchi, K; Kato, A; Sugiyama, H | 1 |
Hasselgren, PO; Hershko, DD; Hungness, ES; Luo, GJ; Pritts, TA; Robb, BW | 1 |
Burton, GR; Lyle, RE; May, JS; McGehee, RE; Prince, AM | 1 |
Andreatta, C; Nahreini, P; Prasad, KN | 1 |
Blystad, FD; Johannessen, LE; Larsen, AM; Longva, KE; Madshus, IH; Stang, E | 1 |
Hui, EK; Nayak, DP | 1 |
Bernstein, A; Donoviel, D; Honjo, T; Karlström, H; Lendahl, U; Lundkvist, J; Mizutani, T; Otaka, A; Taniguchi, Y; Vestling, M | 1 |
Fischer, JE; Hasselgren, PO; Hershko, DD; Hungness, ES; Luo, GJ; Pritts, TA; Robb, BW; Sun, X; Wong, HR | 1 |
Elkon, H; Melamed, E; Offen, D | 1 |
Cavaleyra, M; Daulouede, S; Holzmuller, P; Lemesre, JL; Mangot, I; Sereno, D; Vincendeau, P | 1 |
Bofinger, D; Chen, CY; Koury, ST; Pajak, L; Tamburlin, J | 1 |
Schenkein, D | 1 |
Lin, WW; Wen, HC; Wu, HM | 1 |
Boone, AN; Vijayan, MM | 1 |
Kramer, D; Rondinone, CM | 1 |
Chi, KH; Lin, WW; Wu, HM | 1 |
Melmed, S; Ren, SG; Yu, R | 1 |
Emi, Y; Ikushiro, S; Iyanagi, T; Omura, S | 1 |
Lindquist, S; Ma, J | 1 |
Dai, W; Darzynkiewicz, Z; Jhanwar-Uniyal, M; Liu, T; Luo, L; Ruan, Q; Traganos, F; Wang, Q; Xie, S | 1 |
Bessho, Y; Harada, T; Hirata, H; Kageyama, R; Ohtsuka, T; Yoshikawa, K; Yoshiura, S | 1 |
Chaudhary, PM; Matta, H; Sun, Q | 1 |
Junn, E; Kim, YM; Lee, G; Mouradian, MM; Tanaka, M | 1 |
Hattori, M; Miki, H; Mikoshiba, K; Suetsugu, S; Takenawa, T; Tezuka, T; Yamamoto, T | 1 |
Avraham, HK; Miralem, T | 1 |
Caplan, AJ; Cardozo, CP; Fliss, AE; Hall, SJ; Michaud, C; Ost, MC; Patterson, C; Yang, E | 1 |
Day, BN; McCauley, TC; Sutovsky, M; Sutovsky, P | 1 |
Dean, RT; Rodgers, KJ | 1 |
Brody, JP; Harris, JW; Lin, F; Thompson, HG; Wold, BJ | 1 |
Moreno, MA; Paez, PM; Pasquini, JM; Pasquini, LA; Soto, EF | 1 |
Luker, GD; Luker, KE; Pica, CM; Piwnica-Worms, D; Song, J | 1 |
Calvaruso, G; D'Anneo, A; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R | 1 |
Lenschat, A; Morrison, DC; Perera, PY; Qureshi, N; Shen, J; Splitter, G; Vogel, SN; Zhang, G | 1 |
Fukuda, T; Kurosu, T; Miki, T; Miura, O | 1 |
He, K; Hu, MR; Jin, BF; Lan, Y; Shen, BF; Wang, HX; Wang, J; Wei, KH; Yang, SC; Zhang, XM; Zhou, T | 1 |
Caltagirone, A; Chahine, D; Fillebeen, C; Pantopoulos, K; Segal, P | 1 |
Aki, T; Mizukami, Y; Yoshida, K | 1 |
Barve, SS; Butt, W; Joshi-Barve, S; Klein, J; McClain, CJ | 1 |
Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H | 1 |
Delvin, E; Lambert, M; Levy, E; Seidman, E; Ziv, E; Zoltowska, M | 1 |
Khor, R; McElroy, LJ; Whittaker, GR | 1 |
Bear, MF; Colledge, M; Crozier, RA; Jin, Y; Langeberg, LK; Lu, H; Scott, JD; Snyder, EM; Soderling, JA | 1 |
Akaike, A; Ibi, M; Inden, M; Izumi, Y; Kihara, T; Kitamura, Y; Kohno, R; Nakamizo, T; Nakanishi, M; Sakka, N; Sawada, H; Shibasaki, H; Shimohama, S; Taniguchi, T; Yamakawa, K; Yamamoto, N | 1 |
Awasthi, N; Wagner, BJ | 1 |
Hanson, AJ; Kumar, B; Prasad, KN | 1 |
Evdonin, AL; Medvedeva, ND; Nikol'skiĭ, NN; Tsupkina, NV | 1 |
Bu, G; Li, Y; Lu, W; Schwartz, AL | 1 |
Han, ST; Jin, IN; Kim, OH; Kim, YH; Kwon, TK; Lim, JH; Park, JW; Woo, KJ | 1 |
Karube-Harada, A; Nakamura, Y; Sakata, A; Sugino, N; Taketani, T | 1 |
Benveniste, EN; Choi, C; Choi, K; Jeong, E; Kwon, D; Park, J | 1 |
Chang, YC; Kwon, TK; Lim, JH; Park, JW; Park, YB | 1 |
Goldbaum, O; Richter-Landsberg, C | 1 |
Liang, JN; Marques, C; Pereira, P; Reddy, VN; Shang, F; Szweda, LI; Taylor, A | 1 |
Caamaño, JN; Day, BN; Manandhar, G; McCauley, TC; Sutovsky, M; Sutovsky, P; Thompson, WE | 1 |
Bang, JH; Han, ES; Lee, CS; Lim, I | 1 |
Bakke, M; Børud, B; Cook, C; Fenne, IS; Hoang, T; Lien, EA; Mellgren, G | 1 |
Henfling, ME; Ramaekers, FC; Schutte, B | 1 |
Ballestrero, A; Barbieri, E; Belka, C; Brossart, P; Cardone, MH; Dillon, CP; Garuti, A; Hua, F; Nencioni, A; Patrone, F; Rocco, I; Scheiermann, C; Wesselborg, S; Yokoo, R | 1 |
Allaman-Pillet, N; Billestrup, N; Bonny, C; Karlsen, AE; Mandrup-Poulsen, T; Størling, J | 1 |
Adamo, AM; De Moliner, KL; Perrone Bizzozero, N; Wolfson, ML | 1 |
Baumann, G; Black, RA; Cowan, JW; Frank, SJ; Guan, R; He, K; Jiang, J; Wang, X; Wolfe, MS | 1 |
Gong, Q; Keeney, DR; Molinari, M; Zhou, Z | 1 |
Kabuta, T; Setsuie, R; Wada, K | 1 |
Itoh, K; Kobayashi, A; Kumagai, T; Kusano, Y; Osada, S; Uchida, K; Usami, H; Yamamoto, M | 1 |
Dong, Y; Liu, B; Mei, ZZ; Song, Y; Sun, GJ; Sun, ZX; Zheng, XF | 1 |
Kawatani, Y; Minegishi, N; Shimizu, R; Suzuki, N; Yamamoto, M | 1 |
Cheung, NS; Chiu, LL; Choy, MS; Halliwell, B; Kandiah, J; Koay, ES; Lee, AY; Manikandan, J; Melendez, AJ; Ng, WL; Peng, ZF; Qi, RZ; Whiteman, M; Yew, EH | 1 |
Jarosz-Wilkołazka, A; Staszczak, M | 1 |
Hiramatsu, A; Kiyotani, K; Kuwayama, M; Sakaguchi, T; Shimazu, Y; Sugahara, F; Tanaka, Y; Watanabe, H; Yoshida, T | 1 |
Michael Iuvone, P; Rosiak, J; Zawilska, JB | 1 |
Boncoeur, E; Bonvin, E; Clement, A; Fritah, A; Henrion-Caude, A; Jacquot, J; Lefait, E; Muselet, C; Redeuilh, G; Tabary, O | 1 |
Kaddour-Djebbar, I; Kumar, MV; Lakshmikanthan, V; Lewis, RW; Patel, DM; Shirley, RB | 1 |
Basile, DP; Gama, V; Gomez, JA; Haas, AL; Matsuyama, S; Mayo, LD; Yoshida, T | 1 |
Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
Alao, JP; Coombes, RC; Lam, EW; Stavropoulou, AV; Vigushin, DM | 1 |
Hosler, MR; Wagner, BJ; Wang-Su, ST | 1 |
Kulms, D; Pöppelmann, B; Schwarz, T; Strozyk, E | 1 |
Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W | 1 |
Boggaram, V; Das, A | 1 |
Jacobs, JM; Nichols, RC; Noreault-Conti, TL; Sinclair, JF; Trask, HW; Wrighton, SA | 1 |
Inomata, M; Nakamura, M; Ohno, H; Shintani-Ishida, K; Uemura, K; Yoshida, K | 1 |
Biederbick, A; Chen, G; Fillebeen, C; Lill, R; Pantopoulos, K; Wang, J | 1 |
Dubey, D; Ganesh, S; Mittal, S; Yamakawa, K | 1 |
Inayat-Hussain, SH; Ross, D; Zafar, KS | 1 |
Chellas-Géry, B; Fields, KA; Linton, CN | 1 |
Furuya, H; Harayama, Y; Imanaka, T; Kashiwayama, Y; Maeda, T; Morita, M; Sato, R; Shimozawa, N; Suzuki, Y; Takahashi, N | 1 |
Hainaut, P; Hautefeuille, A; Mion, F; Pétré, A; Roman, S; Scoazec, JY; Thépot, A | 1 |
Jiang, T; Liu, J; Shi, L; Wang, J; Wei, L | 1 |
Chiou, SK; Mandayam, S | 1 |
Kankaanranta, H; Leppänen, T; Moilanen, E; Paukkeri, EL; Sareila, O; Vuolteenaho, K | 1 |
Carlsson, T; Karlsson, JO; Petersen, A; Zetterberg, M | 1 |
Ishimi, Y; Takezawa, J; Yamada, K | 1 |
Akimaru, K; Hirota, R; Nakamura, H | 1 |
Campos, EI; Garate, M; Li, G; Wang, Y; Wong, RP | 1 |
Dorn, R; Hausott, B; Klimaschewski, L; Schlick, B; Vallant, N | 1 |
Bonham, CC; Davisson, VJ; Hindupur, J; Liu, F; Nguyen, JL; Rochet, JC; Ruf, KJ; Schieler, JL; Wood, KV; Zhu, J | 1 |
Faustman, EM; Hong, S; Yu, X | 1 |
Lim, G; Mao, J; Sung, B; Wang, S; Yang, L | 1 |
Faurschou, A; Gniadecki, R | 1 |
Ding, J; Feng, JM; Miao, ZH; Zhang, XW; Zhu, H | 1 |
Hong, HM; Song, EJ; Yoo, YS | 1 |
Fujisawa, E; Koya, D; Ohshima, S; Sasaoka, T; Tsuneki, H; Wada, T | 1 |
Hashimoto, T; Ibuki, T; Iwanaga, T; Kishibuchi, R; Kitagawa, H; Mizuguchi, H; Momota, H; Nishihara, S; Onaka, Y; Sado, M; Wada, D; Watanabe, TK; Yamasaki, Y | 1 |
Moir, RD; Myre, MA; Tanzi, RE; Tesco, G; Wasco, W; Washicosky, K | 1 |
Fu, JJ; Lin, P; Lv, XY; Tsang, BK; Wang, H; Wang, HX; Yan, XJ; Yu, XG; Zhu, C | 1 |
Chapman, D; Dhalla, NS; Elimban, V; Maddika, S | 1 |
Adeli, K; Qiu, W; Rutledge, AC; Su, Q; Zhang, J | 1 |
Chung, RS; Dickson, TC; Staal, JA; Vickers, JC | 1 |
Akamatsu, K; Hirano, T; Ichikawa, T; Ichinose, M; Koarai, A; Matsunaga, K; Minakata, Y; Sugiura, H; Yanagisawa, S | 1 |
Heikkila, JJ; Young, JT | 1 |
Kubo, M; Obata, F; Ohta, E | 1 |
Amano, T; Kameyama, N; Mochizuki, H; Nobukuni, M; Okada, S; Sakai, N; Seki, T; Tanaka, A; Yamamoto, H | 1 |
Kawakami, T; Kirita, T; Morisugi, T; Tanaka, Y | 1 |
Han, YH; Kim, SH; Kim, SZ; Park, WH | 1 |
Han, YH; Park, WH | 1 |
Han, YH; Kim, SH; Kim, SZ; Moon, HJ; Park, WH; You, BR | 1 |
Chen, TC; Ghosh, A; Joo, NE; Kapila, YL | 1 |
Han, YH; Kim, SZ; Park, WH; Yang, YM | 1 |
Kim, SY; Park, JW | 1 |
Bui, TN; Efuet, ET; Keyomarsi, K | 1 |
Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM | 1 |
Arawaka, S; Fukushima, S; Hara, S; Kato, T; Koyama, S; Machiya, Y; Sakamoto, M; Sato, H | 1 |
Gao, G; Luo, H; Wong, J; Zhang, J | 1 |
Hamatani, H; Hiromura, K; Kuroiwa, T; Maeshima, A; Nojima, Y; Sakairi, T; Takahashi, S; Takeuchi, S; Tomioka, M | 1 |
Amara, A; Arenzana-Seisdedos, F; Bonazzi, M; Cossart, P; Fernandez-Garcia, MD; Meertens, L | 1 |
Traynor, JR; Wang, Q | 1 |
Chaggar, K; Dolphin, AC; Ferron, L; Page, KM; Waithe, D | 1 |
Chodaparambil, JV; Felsher, DW; Huang, M; Kusler, B; Mitchell, BS; Pollyea, DA; Whang, P; Xu, L | 1 |
Gui, Y; Jiang, Y; Li, H; Li, J; Yin, H; Zheng, XL | 1 |
Fukaya, M; Kaneki, M; Kim, M; Kitamura, T; Mao, J; Shimizu, N; Shinozaki, S; Tamura, Y; Tanioka, T | 1 |
Alvarez-Velilla, R; Balaña-Fouce, R; Estrada, CG; Pérez-Pertejo, Y; Reguera, RM | 1 |
Fujimuro, M; Higashi, C; Niinaka, Y; Noguchi, K; Saji, C; Yamada, K | 1 |
Jitsukawa, M; Kyogoku, H; Miyano, T; Ogushi, S | 1 |
Fujita, J; Higashitsuji, H; Itoh, K; Kudo, M; Ryu, U; Sakurai, T | 1 |
Ann, EJ; Kim, MY; Kim, SM; Mo, JS; Park, HS; Yoon, JH | 1 |
Bekier, ME; Borton, MT; Date, D; Dreier, MR; Taylor, WR | 1 |
Ha, YH; Kim, YE; Kwon, HJ; Lee, Y; Park, JA | 1 |
Bhattacharya, K; Datta, K; Dutta, D; Li, J; Mandal, C; Pal, BC; Samanta, SK; Sarkar, S | 1 |
Baltrusch, S; Hofmeister-Brix, A; Lenzen, S | 1 |
Choi, HJ; Crum, TS; Gleixner, AM; Jiang, Y; Leak, RK; Pant, DB; Posimo, JM; Pulugulla, SH; Rumble, JL; Unnithan, AS | 1 |
Jeng, CJ; Liao, CK; Wang, HS; Wang, SH; Wu, JC | 1 |
Beller, M; Giese, AK; Gläser, A; Lukas, J; Pockrandt, AM; Pohlers, S; Rolfs, A; Runge, F; Seemann, S; Sharif, M; Zheng, C | 1 |
Adams, B; Essop, MF; Mapanga, RF | 1 |
Goupil, S; Lachance, C; Leclerc, P; Tremblay, RR | 1 |
Brilot, F; Fonteneau, JF; Gannagé, M; Münz, C | 1 |
Heinemann, SD; Hutchison, DF; Leak, RK; Mason, DM; Posimo, JM | 1 |
Khan, NA; Saleem, S; Siddiqui, R | 1 |
Bousquet-Dubouch, MP; Burlet-Schiltz, O; Chaoui, K; Gonzalez-de-Peredo, A; Marcellin, M; Matondo, M; Monsarrat, B | 1 |
Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS | 1 |
Lee, Y; Park, HB; Park, JA; Park, S; Yoo, H | 1 |
Bhatia, TN; Brodsky, JL; Flaherty, PT; Gleixner, AM; Hutchison, DF; Leak, LC; Leak, RK; Sannino, S; Wipf, P | 1 |
Chatterjee Bhowmick, D; Jeremic, A | 1 |
Arbiza, J; Campos, D; González-Santamaría, J; Llamas-González, YY; Pascale, JM | 1 |
Han, K; Huang, X; Li, Y; Liu, Q; Liu, Y; Yang, J; Zhang, L; Zhao, D | 1 |
Daude, N; Kang, SG; Kar, S; Mays, CE; Westaway, D; Yang, J | 1 |
Lee, BH; Nicola, AV; Schneider, SM | 1 |
3 review(s) available for acetylcysteine and leupeptins
Article | Year |
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Proteasome inhibitors: valuable new tools for cell biologists.
Topics: Acetylcysteine; Animals; Antigen Presentation; Boron Compounds; Cysteine Endopeptidases; Depression, Chemical; Endopeptidases; Heat-Shock Proteins; Humans; Leupeptins; Mammals; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteins; Sulfones; Ubiquitins; Yeasts | 1998 |
Proteasome inhibitors in the treatment of B-cell malignancies.
Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Cycle Proteins; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzymes; Gene Expression Regulation; Hodgkin Disease; Humans; Leukemia, B-Cell; Leupeptins; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Mice; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Proteins; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Substrate Specificity; Transcription Factors; Treatment Outcome | 2002 |
Viral entry and the ubiquitin-proteasome system.
Topics: Acetylcysteine; Animals; Antiviral Agents; Bortezomib; Host Microbial Interactions; Humans; Leupeptins; Nucleocapsid; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ubiquitin; Virion; Virus Internalization; Virus Physiological Phenomena; Viruses | 2021 |
251 other study(ies) available for acetylcysteine and leupeptins
Article | Year |
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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.
Topics: Acetylcysteine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endopeptidases; Endoplasmic Reticulum; Humans; Leupeptins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ubiquitins | 1995 |
In vivo ubiquitination and proteasome-mediated degradation of p53(1).
Topics: Acetylcysteine; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; RNA, Messenger; Tumor Suppressor Protein p53; Ubiquitins | 1996 |
Proteasomes play an essential role in thymocyte apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; DNA Ligases; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes | 1996 |
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 1; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Ligases; Electrophoresis, Polyacrylamide Gel; Leupeptins; Multienzyme Complexes; Nerve Growth Factors; Neurons; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Rats; Sympathetic Nervous System | 1996 |
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae.
Topics: Acetylcysteine; Animals; Kinetics; Leupeptins; Mammals; Muramidase; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Ubiquitins; Vacuoles | 1996 |
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
Topics: Acetylcysteine; Blotting, Western; Cell Nucleus; Cysteine Endopeptidases; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Humans; Interferon-gamma; Leupeptins; Multienzyme Complexes; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1996 |
The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
Topics: Acetylcysteine; Animals; Antigen-Presenting Cells; Antigens, Viral; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Epitopes; H-2 Antigens; Humans; Leupeptins; Mice; Multienzyme Complexes; Nucleocapsid Proteins; Nucleoproteins; Orthomyxoviridae; Peptides; Proteasome Endopeptidase Complex; Signal Transduction; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Core Proteins | 1997 |
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.
Topics: Acetylcysteine; Amino Acid Sequence; Brefeldin A; CD4 Antigens; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Products, env; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Signal Transduction; Viral Regulatory and Accessory Proteins | 1997 |
Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome.
Topics: Acetylcysteine; beta 2-Microglobulin; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Histocompatibility Antigens Class I; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Folding; Solubility; Transfection; Tumor Cells, Cultured | 1997 |
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
Topics: Acetylcysteine; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Endoplasmic Reticulum; Fungal Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; RNA, Messenger | 1997 |
Evidence of proteasome-mediated cytochrome P-450 degradation.
Topics: Acetylcysteine; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Leupeptins; Microsomes, Liver; Mixed Function Oxygenases; Multienzyme Complexes; Oxidoreductases, N-Demethylating; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 1997 |
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Evidence for participation of a calpain-like cysteine protease in cell cycle progression through late G1 phase.
Topics: Acetylcysteine; Calpain; Cell Cycle; Cell Line; Cysteine Proteinase Inhibitors; Diazomethane; Fibroblasts; G1 Phase; Humans; Leupeptins; Oligopeptides; S Phase | 1997 |
Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors.
Topics: Acetylcysteine; Animals; Antithrombin III; Brefeldin A; Cell Line; Cricetinae; Cyclopentanes; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Kidney; Leupeptins; Multienzyme Complexes; Mutagenesis, Site-Directed; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Transfection | 1997 |
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cysteine Endopeptidases; Endoplasmic Reticulum; Epitopes; Hexosaminidases; Histocompatibility Antigens Class I; HLA-A2 Antigen; Humans; Leupeptins; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Sorting Signals; Self Tolerance; T-Lymphocytes, Cytotoxic | 1997 |
Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Animals; Cell Line; Cyclic AMP; Cyclic AMP Response Element Modulator; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Ion Channels; Leupeptins; Multienzyme Complexes; Myocardium; Neurons; Proteasome Endopeptidase Complex; Rats; Repressor Proteins; Transcription, Genetic; Ubiquitins | 1997 |
Specificities of cell permeant peptidyl inhibitors for the proteinase activities of mu-calpain and the 20 S proteasome.
Topics: Acetylcysteine; Calcium-Binding Proteins; Calpain; Catalysis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diazomethane; Enzyme Precursors; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Muramidase; Oligopeptides; Plant Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Serine Proteinase Inhibitors; Ubiquitins | 1997 |
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.
Topics: Acetylcysteine; Breast Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; DNA Replication; Female; Histones; Hot Temperature; Humans; Leupeptins; Multienzyme Complexes; Nucleoproteins; Nucleosomes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitins | 1997 |
Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cecum; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Kinetics; Leupeptins; Male; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Transcription, Genetic; Ubiquitins | 1998 |
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters | 1998 |
Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Flow Cytometry; Interphase; Leupeptins; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; S Phase; Trypanosoma brucei brucei | 1997 |
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis.
Topics: Acetylcysteine; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Leupeptins; Lymphoma; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1998 |
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.
Topics: Acetylcysteine; Calcium-Binding Proteins; Calnexin; CD4 Antigens; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Cytosol; Enzyme Activation; Glycoproteins; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Multienzyme Complexes; Mutagenesis; Proteasome Endopeptidase Complex; Ubiquitins; Viral Regulatory and Accessory Proteins | 1998 |
Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1.
Topics: Acetylcysteine; beta-Galactosidase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Viral; Gene Products, tat; HeLa Cells; HIV Core Protein p24; HIV-1; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; tat Gene Products, Human Immunodeficiency Virus; Tumor Cells, Cultured | 1998 |
Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition.
Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylphosphatidylinositols; Human Growth Hormone; Humans; Leupeptins; Multienzyme Complexes; Mutation; Peptides; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sulfhydryl Compounds; Ubiquitins | 1998 |
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.
Topics: Acetylcysteine; Adenoviridae; Animals; Animals, Newborn; Cell Cycle; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Gene Expression Regulation; Keratinocytes; Leupeptins; Membrane Proteins; Mice; Mutation; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Succinates; Transfection | 1998 |
Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway.
Topics: Acetylcysteine; Apolipoproteins B; Biological Transport; Cell Membrane Permeability; Chromans; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leupeptins; Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Tumor Cells, Cultured; Vitamin E | 1998 |
Inhibition of glucose trimming with castanospermine reduces calnexin association and promotes proteasome degradation of the alpha-subunit of the nicotinic acetylcholine receptor.
Topics: Acetylcysteine; Biopolymers; Calcium-Binding Proteins; Calnexin; Calreticulin; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimerization; DNA, Complementary; Glucose; Heat-Shock Proteins; Humans; Hydrolysis; Indolizines; Isomerases; Leupeptins; Multienzyme Complexes; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Binding; Protein Disulfide-Isomerases; Receptors, Nicotinic; Ribonucleoproteins; Transfection; Ubiquitins | 1998 |
Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Glycine; Histocompatibility Antigens Class I; HLA-A Antigens; Humans; Leupeptins; Membrane Proteins; Mice; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Time Factors; Viral Matrix Proteins | 1998 |
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway.
Topics: Acetylcysteine; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leupeptins; Neuroblastoma; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus Infections; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Tumor Virus Infections; Ubiquitins | 1998 |
Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats.
Topics: Acetylcysteine; Animals; Burns; Culture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Lactones; Leupeptins; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tyrosine; Ubiquitins | 1998 |
The ubiquitin-proteasome system and cellular proliferation and regulation in osteoblastic cells.
Topics: Acetylcysteine; Animals; Biopolymers; Cell Division; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Proteasome Endopeptidase Complex; Second Messenger Systems; Teriparatide; Tumor Cells, Cultured; Ubiquitins | 1998 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Fluorescence; Fungal Proteins; Histocompatibility Antigens Class I; Isocoumarins; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Vertebrates | 1998 |
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Immediate-Early Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Tyrosine; Ubiquitins | 1998 |
Proteolysis negatively regulates agonist-stimulated arachidonic acid metabolism.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Carcinogens; Cell Line; Endopeptidases; Epoprostenol; Leupeptins; Lyngbya Toxins; Phenylmethylsulfonyl Fluoride; Prostaglandin-Endoperoxide Synthases; Protease Inhibitors; Rats; Signal Transduction | 1998 |
Calpain involvement in calphostin C-induced apoptosis.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Naphthalenes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; U937 Cells; Ubiquitins | 1998 |
Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome.
Topics: Acetylcysteine; Animals; Arthritis; Boronic Acids; Cell Adhesion Molecules; Cytokines; Dipeptides; Endothelium, Vascular; Female; HeLa Cells; Humans; Hypersensitivity, Delayed; Jurkat Cells; Leupeptins; NF-kappa B; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Rats, Inbred Lew; T-Lymphocytes | 1999 |
Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Fibroblasts; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Phosphorylation; Receptors, Estrogen; Transcription Factors | 1999 |
Presecretory degradation of apolipoprotein [a] is mediated by the proteasome pathway.
Topics: Acetylcysteine; Animals; Apolipoproteins A; Calnexin; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fabaceae; Hepatocytes; Hexosaminidases; Leupeptins; Mannosidases; Molecular Chaperones; Multienzyme Complexes; Papio; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Transfection; Ubiquitin | 1999 |
Proteasome-dependent degradation of the human estrogen receptor.
Topics: Acetylcysteine; Animals; Arabidopsis; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Escherichia coli; Estradiol; HeLa Cells; Humans; Kinetics; Leupeptins; Mammals; Multienzyme Complexes; Proteasome Endopeptidase Complex; Receptors, Estrogen; Receptors, Progesterone; Receptors, Thyroid Hormone; Recombinant Proteins; Substrate Specificity; Transfection; Ubiquitins | 1999 |
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Bucladesine; Calpain; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Dipeptides; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketones; Leupeptins; Lovastatin; Nuclear Proteins; Protein Processing, Post-Translational; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Tumor Cells, Cultured | 1999 |
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia; Leupeptins; Molecular Weight; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Signal Transduction; Time Factors; Tumor Cells, Cultured; Ubiquitins | 1999 |
Inhibition of cytoplasmic antigen, glucose- 6-phosphate dehydrogenase, by VH-CH1, an intracellular Fd fragment antibody derived from a semisynthetic Fd fragment phage display library.
Topics: Acetylcysteine; Animals; Cell Line; Cricetinae; Cricetulus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Inovirus; Isopropyl Thiogalactoside; Kinetics; Leupeptins; Multienzyme Complexes; Peptide Library; Proteasome Endopeptidase Complex; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 1999 |
Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Female; Fibrosarcoma; Humans; Leupeptins; Mitomycin; Oncogene Proteins, Viral; Papillomaviridae; Polymorphism, Genetic; Repressor Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 1999 |
Ubiquitin-proteasome system is involved in induction of LFA-1/ICAM-1-dependent adhesion of HL-60 cells.
Topics: Acetylcysteine; Adenosine Triphosphatases; Antibody Affinity; Cell Adhesion; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HL-60 Cells; Humans; Intercellular Adhesion Molecule-1; Leupeptins; Lymphocyte Function-Associated Antigen-1; Monocytes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tetradecanoylphorbol Acetate; Tretinoin; Ubiquitins | 1999 |
C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycopeptides; Humans; Leucine; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Pepstatins; Presenilin-1; Presenilin-2; Proteasome Endopeptidase Complex; Recombinant Proteins; Sulfones; Transfection | 1999 |
Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hepatitis B virus; Humans; Leupeptins; Multienzyme Complexes; Peptide Hydrolases; Proteasome Endopeptidase Complex; Substrate Specificity; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Ubiquitins; Viral Regulatory and Accessory Proteins | 1999 |
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins | 1999 |
The degradation of nascent fibrinogen chains is mediated by the ubiquitin proteasome pathway.
Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Immunosorbent Techniques; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Transfection; Ubiquitins | 1999 |
Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome.
Topics: Acetylcysteine; Animals; Cadherins; Cell Line; Cell Movement; Chemotaxis; Connexins; Cysteine Endopeptidases; Dogs; Epithelial Cells; Hepatocyte Growth Factor; Immunohistochemistry; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oncogene Protein pp60(v-src); Phosphoproteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Tight Junctions; Zonula Occludens-1 Protein | 1999 |
Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Leupeptins; Microtubules; Mitosis; Multienzyme Complexes; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
A role for the proteasome in the light response of the timeless clock protein.
Topics: Acetylcysteine; Animals; Biological Clocks; Cells, Cultured; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Darkness; Drosophila; Drosophila Proteins; Feedback; Insect Proteins; Leucine; Leupeptins; Light; Multienzyme Complexes; Neurons; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitins | 1999 |
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins | 1999 |
Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells.
Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glioma; Glycoproteins; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Multiple; Glycosylation; Humans; Leupeptins; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Precursors; Protein Processing, Post-Translational | 1999 |
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
Topics: Acetylcysteine; Administration, Topical; Calcitriol; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Gene Expression Regulation; Humans; Keratinocytes; Leucine; Leupeptins; Multienzyme Complexes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Receptors, Calcitriol; Skin; Steroid Hydroxylases; Ubiquitins; Vitamin D3 24-Hydroxylase | 1999 |
Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Hot Temperature; HSP70 Heat-Shock Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; Transcription Factors | 1999 |
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Carcinogenicity Tests; Cell Differentiation; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, Dominant; Genes, Tumor Suppressor; Humans; Leupeptins; Lung Neoplasms; Mice; Mice, Nude; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; B-Lymphocytes; bcl-X Protein; Canavanine; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Synergism; Enzyme Activation; Hematopoietic Stem Cells; HSP70 Heat-Shock Proteins; Interleukin-3; Leupeptins; Mice; Multienzyme Complexes; Oligonucleotides, Antisense; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2 | 1999 |
Nuclear factor kappa B mediates interleukin-8 production in eosinophils.
Topics: Acetylcysteine; Cell Nucleus; Cysteine Proteinase Inhibitors; Densitometry; Electrophoresis; Enzyme-Linked Immunosorbent Assay; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunohistochemistry; Immunosuppressive Agents; Interleukin-8; Leupeptins; NF-kappa B; Tacrolimus; Tumor Necrosis Factor-alpha | 1999 |
Delayed and sustained activation of p42/p44 mitogen-activated protein kinase induced by proteasome inhibitors through p21(ras) in PC12 cells.
Topics: Acetylcysteine; Animals; Autocrine Communication; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; ets-Domain Protein Elk-1; Leupeptins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Neurites; PC12 Cells; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Rats; Time Factors; Transcription Factors | 2000 |
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins | 2000 |
A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Binding, Competitive; Cell Compartmentation; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Endoplasmic Reticulum; Humans; Hydrolysis; Intracellular Fluid; Leupeptins; Multienzyme Complexes; Neurons; Peptide Fragments; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Tumor Cells, Cultured | 2000 |
A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Structure, Secondary; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Tyrosine | 2000 |
Accumulation and degradation in the endoplasmic reticulum of a truncated ER-60 devoid of C-terminal amino acid residues.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Carrier Proteins; Cell Membrane; COS Cells; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochalasin B; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Half-Life; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Proteins; Molecular Chaperones; Protein Disulfide-Isomerases; Recombinant Proteins; Ribonucleoproteins | 2000 |
p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; Humans; Leupeptins; Microtubule-Associated Proteins; Mouth Mucosa; Mouth Neoplasms; Multienzyme Complexes; Oligonucleotides, Antisense; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Precursors; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
The proteasome is involved in the first metaphase-to-anaphase transition of meiosis in rat oocytes.
Topics: Acetylcysteine; Anaphase; Animals; Cyclin B; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Leupeptins; Meiosis; Metaphase; Multienzyme Complexes; Oligopeptides; Oocytes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Spindle Apparatus | 2000 |
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Hepatitis B e Antigens; Histocompatibility Antigens Class I; HIV Envelope Protein gp160; HIV-1; Humans; Hydrolysis; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic | 2000 |
Differential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cell Line; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Fibroblasts; Fluorescent Dyes; Humans; Immunoblotting; Indoles; Leupeptins; Mice; Mice, Knockout; Microscopy, Fluorescence; Multienzyme Complexes; Oligopeptides; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteins; Time Factors; Tumor Suppressor Protein p53 | 2000 |
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Caspase 3; Caspase 7; Caspase Inhibitors; Caspases; Cell Death; Crk-Associated Substrate Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Mitosis; Multienzyme Complexes; Mutation; Oligopeptides; Peptide Fragments; Phosphoproteins; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Isoforms; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1.
Topics: Acetylation; Acetylcysteine; Animals; Anti-Bacterial Agents; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chickens; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeleton; Down-Regulation; Enzyme Inhibitors; Female; G1 Phase; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoblotting; Keratins; Leupeptins; Multienzyme Complexes; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Quinidine; Retinoblastoma Protein; Time Factors; Tumor Cells, Cultured | 2000 |
Activation-dependent degradation of protein kinase C eta.
Topics: Acetylcysteine; Animals; Cell Fractionation; Cell Line; Chick Embryo; Cricetinae; Cysteine Endopeptidases; Detergents; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Humans; Isoenzymes; Kidney; Leupeptins; Membrane Proteins; Mesocricetus; Mice; Multienzyme Complexes; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Conformation; Protein Kinase C; Protein Kinase C-theta; Rats; Recombinant Fusion Proteins; Sindbis Virus; Tumor Cells, Cultured; Ubiquitins | 2000 |
Proteasome inhibitors block the entry of liposome-encapsulated antigens into the classical MHC class I pathway.
Topics: Acetylcysteine; Animals; Bone Marrow Cells; Conalbumin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Golgi Apparatus; Histocompatibility Antigens Class I; Leupeptins; Liposomes; Macrophages; Mice; Models, Biological; Multienzyme Complexes; Peptides; Phagocytosis; Proteasome Endopeptidase Complex; Spleen; T-Lymphocytes, Cytotoxic | 2000 |
Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Calpain; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neurites; Neurofilament Proteins; PC12 Cells; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-jun; Rats; Ubiquitins | 2000 |
The proteasome regulates receptor-mediated endocytosis of interleukin-2.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Endocytosis; Interleukin-2; Leupeptins; Lysosomes; Macromolecular Substances; Mice; Mice, Inbred C57BL; Milk Proteins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Subunits; Receptors, Interleukin-2; Spleen; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators | 2001 |
Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells.
Topics: Acetylcysteine; Acute Disease; Adult; Antigens, CD34; Apoptosis; Caspase 3; Caspases; Cell Culture Techniques; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Hematopoietic Stem Cells; Humans; K562 Cells; Leukemia; Leupeptins; Mitosis; Multienzyme Complexes; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Glioma; Humans; Lactams; Leupeptins; Membrane Glycoproteins; Mice; Mitochondria; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Transgenes; Tumor Cells, Cultured | 2000 |
Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; DNA, Protozoan; Endoplasmic Reticulum; Humans; Leupeptins; Microscopy, Electron; Multienzyme Complexes; Proteasome Endopeptidase Complex; Toxoplasma; Toxoplasmosis; Vacuoles | 2000 |
Ubiquitin is part of the retrovirus budding machinery.
Topics: Acetylcysteine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Membrane; Cysteine Endopeptidases; Endocytosis; Gene Products, gag; Leupeptins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Quail; Recombinant Fusion Proteins; Ubiquitins; Virus Replication | 2000 |
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured | 2000 |
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.
Topics: Acetylcysteine; Adenosine Triphosphatases; Carrier Proteins; Cation Transport Proteins; Cell Line; Copper-Transporting ATPases; Cysteine Endopeptidases; Cytoskeleton; Fluorescent Antibody Technique; Humans; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; Tissue Distribution | 2001 |
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.
Topics: Acetylcysteine; Adenosine Triphosphate; Antigens, Neoplasm; Cell Cycle; Cell Extracts; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Isoenzymes; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2001 |
Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Induction; Female; Flow Cytometry; G2 Phase; Glycoproteins; Humans; Immunoblotting; Isoenzymes; Leupeptins; Ovarian Neoplasms; Transfection | 2001 |
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Impairment of the ubiquitin-proteasome system by protein aggregation.
Topics: Acetylcysteine; Amino Acid Sequence; Cell Death; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; G2 Phase; Green Fluorescent Proteins; Humans; Huntingtin Protein; Inclusion Bodies; Leupeptins; Luminescent Proteins; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Nuclear Proteins; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.
Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendrites; DNA-Binding Proteins; Gene Expression; Leupeptins; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Superior Cervical Ganglion; Trans-Activators; Transcriptional Activation; Transfection; Transforming Growth Factor beta | 2001 |
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins | 2001 |
Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
Topics: Acetylcysteine; Apoptosis; Calpain; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Eukaryotic Initiation Factor-4G; fas Receptor; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Jurkat Cells; Leupeptins; Multienzyme Complexes; Peptide Fragments; Peptide Initiation Factors; Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine; T-Lymphocytes | 2001 |
Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptotic Protease-Activating Factor 1; Blotting, Western; Caspase 9; Caspases; Cysteine Endopeptidases; Cytochrome c Group; Cytosol; Enzyme Activation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leupeptins; Microscopy, Electron; Molecular Weight; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteins; Tumor Cells, Cultured | 2001 |
Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.
Topics: Acetylcysteine; Apoptosis; Base Sequence; Brain Neoplasms; Cysteine Proteinase Inhibitors; DNA Primers; Fas Ligand Protein; fas Receptor; Glioma; Humans; Leupeptins; Membrane Glycoproteins; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured | 2001 |
Proteasome inhibitors differentially affect heat shock protein response in cancer cells.
Topics: Acetylcysteine; Antigens, Neoplasm; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Heat-Shock Proteins; HL-60 Cells; Humans; K562 Cells; Leupeptins; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2001 |
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; HeLa Cells; Hepatocytes; Humans; Lactones; Leupeptins; Liver; Mice; Multienzyme Complexes; Mutation; Oligopeptides; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Rats; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.
Topics: Acetylcysteine; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genetic Complementation Test; Hybrid Cells; Leupeptins; Multienzyme Complexes; Point Mutation; Proteasome Endopeptidase Complex; Proteins; Rats; Temperature; Ubiquitin | 2001 |
Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hippocampus; Homer Scaffolding Proteins; Immunohistochemistry; Leupeptins; Multienzyme Complexes; Neuronal Plasticity; Neurons; Neuropeptides; Proteasome Endopeptidase Complex; Synapses; Synaptophysin | 2001 |
Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells.
Topics: Acetylcysteine; Blotting, Western; Caco-2 Cells; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Dose-Response Relationship, Drug; Enterocytes; Enzyme Activation; Epithelial Cells; Heat-Shock Proteins; Hot Temperature; HSP72 Heat-Shock Proteins; Humans; Intestinal Mucosa; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Isoforms; Quercetin; Temperature; Time Factors; Transcription Factors | 2002 |
Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.
Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Nuclear Proteins; Peptide Hydrolases; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Retinoblastoma-Like Protein p130 | 2002 |
Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cyclic AMP; Cyclin B; Cyclin B1; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, myc; Green Fluorescent Proteins; Humans; Leupeptins; Luminescent Proteins; Mice; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Retroviridae; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasmic Vesicles; Endocytosis; Endopeptidases; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Intracellular Membranes; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Transforming Growth Factor alpha; Ubiquitin-Protein Ligases; Ubiquitins | 2002 |
Role of ATP in influenza virus budding.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cell Line; Cell Membrane Permeability; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Enzyme Inhibitors; Humans; Indoles; Influenza A virus; Kinetics; Leupeptins; Lysophosphatidylcholines; Multienzyme Complexes; Oligopeptides; Ouabain; Proteasome Endopeptidase Complex; Sodium-Potassium-Exchanging ATPase; Sulfones; Thapsigargin; Viscosity | 2001 |
Notch receptor cleavage depends on but is not directly executed by presenilins.
Topics: Acetylcysteine; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Extracts; Cell Line; Detergents; Endopeptidases; Fluorometry; Humans; Leupeptins; Membrane Proteins; Mice; Mutation; Presenilin-1; Presenilin-2; Protease Inhibitors; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Notch; Signal Transduction; Solubility | 2002 |
Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.
Topics: Acetylcysteine; Caco-2 Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enterocytes; Epithelial Cells; Gene Expression; Heat Shock Transcription Factors; Heat-Shock Proteins; Heat-Shock Response; HSP72 Heat-Shock Proteins; Humans; Interleukin-6; Intestinal Mucosa; Leupeptins; Multienzyme Complexes; NF-kappa B; Proteasome Endopeptidase Complex; RNA, Messenger; Transcription Factors; Transcriptional Activation | 2002 |
6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Leupeptins; Lewy Bodies; Methionine; Models, Neurological; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Oxidopamine; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Substantia Nigra; Sulfur Radioisotopes; Sympatholytics; Ubiquitins | 2001 |
Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes.
Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA, Protozoan; Female; Glycoproteins; Kinetics; Leishmania mexicana; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Donors; Proteasome Endopeptidase Complex; Sodium Nitrite; Time Factors | 2002 |
The effect of proteasome inhibitors on mammalian erythroid terminal differentiation.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Viral; Cysteine Endopeptidases; Cytoplasm; Erythroid Precursor Cells; Erythropoiesis; Friend murine leukemia virus; Leupeptins; Mice; Multienzyme Complexes; Nuclear Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Reticulocytes; Ubiquitin | 2002 |
Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation.
Topics: Acetylcysteine; Cell Line; Chemotaxis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Epithelial Cells; Genes, Reporter; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neutrophils; NF-kappa B; Proteasome Endopeptidase Complex; ras Proteins; Reactive Oxygen Species; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured | 2002 |
Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Hepatocytes; HSP70 Heat-Shock Proteins; Hydrocortisone; Leupeptins; Multienzyme Complexes; Oncorhynchus mykiss; Proteasome Endopeptidase Complex; Receptors, Glucocorticoid; Sulfur Radioisotopes | 2002 |
Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.
Topics: 3T3 Cells; Acetylcysteine; Adipocytes; Animals; Biological Transport; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glucose; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Leupeptins; Mice; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2002 |
Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.
Topics: Acetylcysteine; Antioxidants; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Genes, Reporter; Humans; Interleukin-8; Leupeptins; Luciferases; Multienzyme Complexes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Recombinant Proteins; Transcription Factor AP-1; Transfection | 2002 |
Proteasome inhibitors induce apoptosis in growth hormone- and prolactin-secreting rat pituitary tumor cells.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspases; Cells, Cultured; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Female; Growth Hormone; In Situ Nick-End Labeling; Leupeptins; Multienzyme Complexes; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactinoma; Proteasome Endopeptidase Complex; Rats; Tumor Cells, Cultured | 2002 |
Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glucuronosyltransferase; Glycoproteins; Half-Life; Hepatocytes; Leupeptins; Male; Monosaccharide Transport Proteins; Multienzyme Complexes; Mutation; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Gunn; Rats, Wistar; RNA, Messenger; Subcellular Fractions | 2002 |
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosol; Endopeptidase K; Endoplasmic Reticulum; Leupeptins; Mice; Models, Biological; Multienzyme Complexes; Neurons; Oligopeptides; Prions; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Transport; PrPSc Proteins; Solubility; Transfection; Tumor Cells, Cultured | 2002 |
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Topics: Acetylcysteine; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Doxorubicin; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oxidative Stress; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Reactive Oxygen Species | 2002 |
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Topics: Acetylcysteine; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Blood; Cell Line; Cycloheximide; Cysteine Endopeptidases; Feedback, Physiological; Gene Expression Regulation; Glycosyltransferases; Half-Life; Homeodomain Proteins; Leupeptins; Mesoderm; Mice; Multienzyme Complexes; PC12 Cells; Periodicity; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Transcription Factor HES-1; Transcription, Genetic; Transfection; Ubiquitin | 2002 |
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.
Topics: Acetylcysteine; Acute Disease; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Cell Transformation, Viral; Enzyme Activation; Gene Expression Regulation, Viral; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 8, Human; Humans; I-kappa B Proteins; Leukemia, Myeloid; Leupeptins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; NF-kappa B; Oxides; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Recombinant Proteins; Rhadinovirus; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Proteins | 2003 |
Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Blotting, Western; Carrier Proteins; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Humans; Inclusion Bodies; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Macromolecular Substances; Mice; Multienzyme Complexes; Nerve Tissue Proteins; Neuroblastoma; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Synucleins; Transfection; Ubiquitin | 2002 |
Sustained activation of N-WASP through phosphorylation is essential for neurite extension.
Topics: Acetylcysteine; Actin-Related Protein 2; Actin-Related Protein 3; Amino Acid Sequence; Animals; cdc42 GTP-Binding Protein; Cell Line; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Female; Leupeptins; Mice; Mice, Inbred ICR; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Neurites; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Spodoptera; src-Family Kinases; Wiskott-Aldrich Syndrome Protein, Neuronal | 2002 |
Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.
Topics: Acetylcysteine; Blotting, Northern; Blotting, Western; BRCA1 Protein; Cell Cycle; Cell Division; Cell Survival; Collagen; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Combinations; Enzyme Inhibitors; Extracellular Matrix; Genetic Vectors; Germ-Line Mutation; Humans; Immunoblotting; Laminin; Leupeptins; MAP Kinase Signaling System; Neuregulin-1; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Polylysine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
Topics: Acetylcysteine; Benzoquinones; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Gene Expression; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Leupeptins; Ligases; Male; Molecular Chaperones; Multienzyme Complexes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Quinones; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Early degradation of paternal mitochondria in domestic pig (Sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and MG132.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Fertilization in Vitro; Fluorescent Antibody Technique; In Vitro Techniques; Leupeptins; Male; Microscopy, Electron; Mitochondria; Mitosis; Multienzyme Complexes; Ovum; Pregnancy; Proteasome Endopeptidase Complex; Sperm Maturation; Spermatozoa; Swine; Ubiquitin; Zygote | 2003 |
Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates.
Topics: Acetylcysteine; Animals; Cell Line; Chromatography, Gel; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Mice; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Substrate Specificity; Ubiquitin | 2003 |
p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Breast; Breast Neoplasms; Carrier Proteins; Cells, Cultured; Computer Systems; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteins; Proto-Oncogene Proteins c-ets; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sequestosome-1 Protein; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation.
Topics: Acetylcysteine; Animals; Bromodeoxyuridine; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Immunohistochemistry; Leupeptins; Macromolecular Substances; Oligodendroglia; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Signal Transduction | 2003 |
Imaging 26S proteasome activity and inhibition in living mice.
Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Coleoptera; Cysteine Proteinase Inhibitors; Genes, Reporter; HeLa Cells; Humans; Kinetics; Leupeptins; Luciferases; Luminescent Measurements; Male; Mice; Mice, Nude; Molecular Biology; Peptide Hydrolases; Proteasome Endopeptidase Complex; Pyrazines; Transfection; Ubiquitin; Xenograft Model Antitumor Assays | 2003 |
Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Cytochromes c; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leupeptins; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Multienzyme Complexes; Osteosarcoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Retinoblastoma Protein; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2003 |
The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events.
Topics: Acetylcysteine; Acute-Phase Proteins; Animals; Carrier Proteins; Cell Line; Chymotrypsin; Cross-Linking Reagents; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Escherichia coli; Glutamate Synthase; Leupeptins; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Membrane Glycoproteins; Membrane Proteins; Methanosarcina; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Shock, Septic; Signal Transduction; Tritium | 2003 |
BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Doxycycline; Etoposide; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Lymphoma, B-Cell; Membrane Potentials; Mitochondria; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-6; Reactive Oxygen Species; Transcription Factors; Tumor Cells, Cultured | 2003 |
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Diamines; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Megakaryoblastic, Acute; Leupeptins; Lysine; Multienzyme Complexes; Oligodeoxyribonucleotides, Antisense; Peptide Initiation Factors; Peptide Mapping; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteomics; RNA-Binding Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin | 2003 |
A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Cell Line; Cysteine Proteinase Inhibitors; Deferoxamine; Humans; Iron; Iron Chelating Agents; Iron Regulatory Protein 1; Leupeptins; Mice; Molecular Sequence Data; Mutation; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine | 2003 |
The mechanism of alphaB-crystallin gene expression by proteasome inhibition.
Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Heat-Shock Response; Leupeptins; Multienzyme Complexes; Myocytes, Cardiac; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Rats | 2003 |
Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes.
Topics: Acetylcysteine; Apoptosis; Cell Death; Cell Line, Tumor; Chemotaxis, Leukocyte; Cysteine Proteinase Inhibitors; DNA; DNA Fragmentation; Enzyme Activation; Fetus; Hepatocytes; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Peptide Hydrolases; Proteasome Endopeptidase Complex; RNA, Messenger; Transcription Factor AP-1; Up-Regulation | 2003 |
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins | 2003 |
Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.
Topics: Acetylcysteine; Animals; Apolipoproteins B; Cells, Cultured; Cysteine Endopeptidases; Diabetes Mellitus; Disease Models, Animal; Gerbillinae; Hepatocytes; Hypercholesterolemia; Hyperinsulinism; Hypertriglyceridemia; Insulin; Insulin Resistance; Leupeptins; Lipoproteins, VLDL; Liver; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex | 2004 |
The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells.
Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Cell Line; Cell Nucleus; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Flow Cytometry; Genes, Dominant; Green Fluorescent Proteins; Hemagglutinins; Hydrogen-Ion Concentration; Leupeptins; Luminescent Proteins; Microscopy, Fluorescence; Mink; Orthomyxoviridae; Plasmids; Protein Transport; Receptor, IGF Type 2; Retroviridae; Saccharomyces cerevisiae Proteins; Time Factors; Transfection; Ubiquitin; Vesicular stomatitis Indiana virus; Virus Replication | 2003 |
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Calcium; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Disks Large Homolog 4 Protein; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Endocytosis; Epitopes; Excitatory Amino Acid Agonists; Hippocampus; Humans; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Membrane Potentials; Membrane Proteins; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Neural Inhibition; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Long-Evans; Receptors, AMPA; Synapses; Synapsins; Tacrolimus; Time Factors; Transfection; Ubiquitin | 2003 |
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; alpha-Synuclein; Animals; Brain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Herbicides; Immunoblotting; Immunohistochemistry; Ions; L-Lactate Dehydrogenase; Leupeptins; Male; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Phosphorylation; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Rotenone; Synucleins; Time Factors; Ubiquitin | 2004 |
Interferon-gamma induces apoptosis of lens alphaTN4-1 cells and proteasome inhibition has an antiapoptotic effect.
Topics: Acetylcysteine; Animals; Annexin A5; Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoprotection; DNA-Binding Proteins; Epithelial Cells; Interferon Regulatory Factor-1; Interferon Regulatory Factors; Interferon-gamma; Lens, Crystalline; Leupeptins; Mice; Multienzyme Complexes; Phosphoproteins; Proteasome Endopeptidase Complex; Recombinant Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Up-Regulation | 2004 |
Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcysteine; Adenylyl Cyclase Inhibitors; Animals; Cell Differentiation; Cell Survival; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Leupeptins; Mice; Multienzyme Complexes; Neuroblastoma; Phosphodiesterase Inhibitors; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2004 |
[Effect of EGF on ubiquitination and proteasome-dependent degradation of phospholipase C gamma1 in A431 cells].
Topics: Acetylcysteine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; Epithelial Cells; Humans; Leupeptins; Multienzyme Complexes; Phospholipase C gamma; Proteasome Endopeptidase Complex; Type C Phospholipases; Ubiquitins | 2003 |
Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.
Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Endoplasmic Reticulum; Humans; Leupeptins; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Transport; Receptors, LDL | 2004 |
Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors.
Topics: Acetylcysteine; Apoptosis; Butyrates; Caspases; Cell Division; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Therapy, Combination; G2 Phase; Humans; Leupeptins; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 2004 |
Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation.
Topics: Acetylcysteine; Adult; Antioxidants; Cells, Cultured; Cyclooxygenase 2; Cysteine Endopeptidases; Dinoprost; Endometrium; Enzyme Activation; Estradiol; Female; Free Radicals; Humans; Isoenzymes; Leupeptins; Medroxyprogesterone Acetate; Membrane Proteins; Menstruation; Multienzyme Complexes; NF-kappa B; Ovary; Oxygen; Progesterone; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Steroids; Stromal Cells; Superoxide Dismutase; Superoxides; Time Factors | 2004 |
Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells.
Topics: Acetylcysteine; Astrocytes; Biphenyl Compounds; Cells, Cultured; Chemokines; Chloroquine; Dose-Response Relationship, Drug; Encephalitis; Humans; Inflammation Mediators; Leupeptins; NF-kappa B; Onium Compounds; Reaction Time; Reactive Oxygen Species; RNA, Messenger; Tosylphenylalanyl Chloromethyl Ketone | 2004 |
Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.
Topics: Acetylcysteine; Antioxidants; Cell Cycle Proteins; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; Glutathione; Humans; Leupeptins; Multienzyme Complexes; Osteosarcoma; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture.
Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Apoptosis; Brain; Cells, Cultured; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Inclusion Bodies; Leupeptins; Microtubules; Oligodendroglia; Oxidative Stress; Phosphorylation; Proteasome Inhibitors; Rats; Rats, Wistar; RNA, Messenger; tau Proteins; Ubiquitin | 2004 |
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Aldehydes; alpha-Crystallin B Chain; Cell-Free System; Cells, Cultured; Epithelial Cells; Humans; Lens, Crystalline; Leupeptins; Lysosomes; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitin | 2004 |
Proteasomal interference prevents zona pellucida penetration and fertilization in mammals.
Topics: Acetylcysteine; Acrosome; Acrosome Reaction; Animals; Exocytosis; Female; Fertilization; Fertilization in Vitro; Immune Sera; Leupeptins; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sperm-Ovum Interactions; Spermatozoa; Swine; Ubiquitin; Zona Pellucida | 2004 |
Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Small Cell; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA Damage; Drug Interactions; Enzyme Activation; Glutathione; Humans; Leupeptins; Membrane Potentials; Mitochondria; Oxidation-Reduction; Tumor Cells, Cultured | 2004 |
Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Breast Neoplasms; Cell Line; Cell Line, Tumor; HT29 Cells; Humans; Leupeptins; Liver; Neuroglia; Oligopeptides; Proteasome Inhibitors; Rats | 2004 |
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcysteine; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Immunoprecipitation; Leupeptins; Luciferases; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Nuclear Receptor Coactivator 2; Protease Inhibitors; Proteasome Endopeptidase Complex; Temperature; Thionucleotides; Time Factors; Transcriptional Activation; Transfection; Ubiquitin | 2004 |
Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lung Neoplasms; Membrane Potentials; Mitochondria; Proteasome Endopeptidase Complex; Purines; Roscovitine; Signal Transduction; Tumor Cells, Cultured | 2004 |
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspases; Cell Survival; Complement Membrane Attack Complex; Complement System Proteins; Cysteine Proteinase Inhibitors; Cytochromes c; Gene Expression; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Leupeptins; Lymphocytes; Mitochondria; Mitochondrial Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA Interference | 2005 |
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Insulinoma; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Pancreatic Neoplasms; Proteasome Inhibitors; Rats; Signal Transduction; Tumor Suppressor Protein p53 | 2005 |
Growth-associated protein-43 is degraded via the ubiquitin-proteasome system.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; GAP-43 Protein; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Immunohistochemistry; Immunoprecipitation; Leupeptins; Male; Mice; Mutagenesis; Neurons; NIH 3T3 Cells; Pregnancy; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Transfection; Ubiquitin | 2005 |
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adenoviridae; Adipocytes; Animals; Cell Line; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytoplasm; Down-Regulation; Fibroblasts; Growth Hormone; Humans; Immunoblotting; Immunoprecipitation; Kinetics; Leupeptins; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Microscopy, Confocal; Models, Biological; Plasmids; Presenilin-1; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Structure, Tertiary; Receptors, Somatotropin; Recombinant Proteins; Signal Transduction; Time Factors | 2005 |
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Leupeptins; Long QT Syndrome; Mutation; Potassium Channels; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleases; Subcellular Fractions; Time Factors; Transfection; Ubiquitin | 2005 |
Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration?
Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Lewy Bodies; Neurotoxins; Oxidopamine; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protective Agents; Rats; Substantia Nigra | 2005 |
Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Biomarkers, Tumor; Blotting, Western; Cysteine; DNA-Binding Proteins; DNA, Complementary; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; Glutathione S-Transferase pi; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lactones; Leupeptins; Luciferases; Mice; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Time Factors; Trans-Activators; Transfection; Up-Regulation | 2005 |
[Inhibiting expression of human telomerase reverse transcriptase promotes degradation of survivin protein].
Topics: Acetylcysteine; Cell Proliferation; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Leupeptins; Microtubule-Associated Proteins; Neoplasm Proteins; Oligonucleotides, Antisense; RNA, Messenger; Survivin; Telomerase | 2005 |
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Deletion; Gene Expression Regulation; Half-Life; Humans; Leukemia, Experimental; Leupeptins; Mice; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Ubiquitins; Ultraviolet Rays | 2005 |
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Gene Expression; Gene Expression Profiling; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Molecular Chaperones; Muscle Proteins; Neurons; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Transcription, Genetic; Transfection; Up-Regulation | 2005 |
Inhibition of the proteasome strongly affects cadmium stimulated laccase activity in Trametes versicolor.
Topics: Acetylcysteine; Cadmium; Chloroquine; Dose-Response Relationship, Drug; Fungal Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Laccase; Leupeptins; Mycelium; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2005 |
Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cell Line; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; HN Protein; Influenza A virus; Leupeptins; Macaca mulatta; Macrophages; Orthomyxoviridae; Paramyxoviridae; Proteasome Inhibitors; Rhabdoviridae; Sendai virus; Vesicular stomatitis Indiana virus; Viral Fusion Proteins; Viral Matrix Proteins; Virus Assembly; Virus Replication | 2005 |
UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis.
Topics: Acetylcysteine; Animals; Arylalkylamine N-Acetyltransferase; Bucladesine; Chickens; Colforsin; Cyclic AMP; Dark Adaptation; Leupeptins; Male; Oligopeptides; Organ Culture Techniques; Pineal Gland; Proteasome Endopeptidase Complex; Time Factors; Ultraviolet Rays | 2005 |
Oxidative stress response results in increased p21WAF1/CIP1 degradation in cystic fibrosis lung epithelial cells.
Topics: Acetylcysteine; Annexin A5; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cysteine Proteinase Inhibitors; Cystic Fibrosis; Epithelial Cells; Humans; Hyperoxia; Leupeptins; Lung; Oxidative Stress; Oxygen; Reactive Oxygen Species; S Phase | 2006 |
Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; I-kappa B Kinase; Leupeptins; Male; NF-kappa B; Prostatic Neoplasms; Proteasome Inhibitors; Tumor Cells, Cultured | 2005 |
Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antigens, Nuclear; Apoptosis; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Doxorubicin; Gene Expression; HeLa Cells; Humans; Ku Autoantigen; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Signal Transduction; Staurosporine; Ubiquitin; Ubiquitin-Protein Ligase Complexes | 2006 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Cytoplasm; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Karyopherins; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA Interference; Transfection; Ubiquitin | 2006 |
Role of the proteasome in TGF-beta signaling in lens epithelial cells.
Topics: Acetylcysteine; Actins; Annexins; Blotting, Western; Cataract; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Fibronectins; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutamate-Cysteine Ligase; Humans; Intracellular Signaling Peptides and Proteins; Lens, Crystalline; Leupeptins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transcriptional Activation; Transforming Growth Factor beta | 2006 |
Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Chromosome Breakage; Cisplatin; Comet Assay; DNA Damage; Doxorubicin; Etoposide; Gamma Rays; Gene Expression Regulation; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Interleukin-6; KB Cells; Leupeptins; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Proteasome Inhibitors; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sulfones; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2006 |
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression.
Topics: Acetylcysteine; Base Sequence; Cell Line; Cysteine Proteinase Inhibitors; Dexamethasone; DNA-Binding Proteins; Epithelial Cells; Gene Expression; Humans; Leupeptins; Lung; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein C; RNA, Messenger; Transcription Factors | 2007 |
Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.
Topics: Acetylcysteine; Animals; Arsenites; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Hepatocytes; Leupeptins; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Inbred F344; RNA, Messenger | 2006 |
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.
Topics: Acetylcysteine; Calpain; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cell Death; Cell Line, Tumor; Delta Catenin; Dipeptides; Humans; Ischemia; Leupeptins; Neuroblastoma; Phosphoproteins | 2007 |
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Carbon-Sulfur Lyases; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Humans; Iron; Iron Regulatory Protein 1; Leupeptins; Metabolic Networks and Pathways; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Transcriptional Activation; Ubiquitin | 2007 |
Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Cell Line, Tumor; Centrosome; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Inclusion Bodies; Lafora Disease; Leupeptins; Microscopy, Fluorescence; Proteasome Endopeptidase Complex; Protein Binding; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Recombinant Fusion Proteins; Transfection; Tubulin; Ubiquitin; Ubiquitin-Protein Ligases | 2007 |
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132.
Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Leupeptins; Mesencephalon; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Substantia Nigra | 2007 |
Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model.
Topics: Acetylcysteine; Bacterial Proteins; Chlamydia Infections; Chlamydia trachomatis; Gene Library; HeLa Cells; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Interaction Mapping; Transcription Factors; Yersinia | 2007 |
Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.
Topics: Acetylcysteine; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; CHO Cells; Cricetinae; Cricetulus; Fibroblasts; Humans; Leupeptins; Mutation, Missense; Proteasome Inhibitors; Subcellular Fractions | 2007 |
Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.
Topics: Acetylcysteine; Apoptosis; Barrett Esophagus; Carcinoma, Squamous Cell; Cell Line, Tumor; Cells, Cultured; Chenodeoxycholic Acid; Cyclooxygenase 2; Deoxycholic Acid; DNA-Binding Proteins; Down-Regulation; Doxorubicin; Esophageal Neoplasms; Esophagus; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Leupeptins; Proteasome Inhibitors; Taurochenodeoxycholic Acid; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins | 2007 |
Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Antiviral Agents; Apoptosis; Cell Line; Chick Embryo; Chickens; Cytopathogenic Effect, Viral; Fibroblasts; Infectious bursal disease virus; Leupeptins; Proteasome Inhibitors; Protein Biosynthesis; RNA, Viral; Transcription, Genetic; Viral Proteins; Virus Internalization | 2007 |
NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Cysteine Proteinase Inhibitors; Epithelial Cells; Indomethacin; Leupeptins; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; RNA, Messenger; Stomach; Survivin; Ubiquitination | 2007 |
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
Topics: Acetylcysteine; Animals; Butyrates; Cells, Cultured; Dose-Response Relationship, Drug; Leupeptins; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenylurea Compounds; PPAR alpha; Proteasome Endopeptidase Complex; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor | 2007 |
The proteasome and intracellular redox status: implications for apoptotic regulation in lens epithelial cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; In Vitro Techniques; Intracellular Membranes; Lens, Crystalline; Leupeptins; Mice; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptide Hydrolases; Proteasome Endopeptidase Complex | 2007 |
Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.
Topics: Acetylcysteine; Boronic Acids; Caffeine; Cells, Cultured; Cisplatin; Cysteine Proteinase Inhibitors; DNA Damage; DNA Repair; DNA Replication; HeLa Cells; Humans; Leupeptins; Neoplasms; Proteasome Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays | 2008 |
In vitro toxicity evaluation of diesel exhaust particles on human eosinophilic cell.
Topics: Acetylcysteine; Cell Movement; Chemokine CCL2; Chemotaxis; Clone Cells; Eosinophils; HL-60 Cells; Humans; Interleukin-8; Leupeptins; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Up-Regulation; Vehicle Emissions | 2008 |
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
Topics: Acetylcysteine; Animals; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Leupeptins; NAD(P)H Dehydrogenase (Quinone); Nuclear Proteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine; Tumor Suppressor Proteins; Ultraviolet Rays | 2008 |
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.
Topics: Acetylcysteine; Animals; Blotting, Western; Cysteine Proteinase Inhibitors; Fibroblast Growth Factors; Ganglia, Spinal; Green Fluorescent Proteins; Leupeptins; Ligands; Lysosomes; Neurites; PC12 Cells; Pheochromocytoma; Rats; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction | 2008 |
Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Antioxidants; Blotting, Western; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Mesencephalon; Methionine Sulfoxide Reductases; Mice; Neurons; Oxidation-Reduction; Oxidoreductases; Parkinson Disease; Rats; Rotenone; Uncoupling Agents; Vitamin E | 2008 |
Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.
Topics: Acetylcysteine; Animals; Apoptosis; Cadmium Compounds; Cell Survival; Cells, Cultured; Coculture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Leupeptins; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Spermatogonia; Ubiquitins | 2008 |
Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.
Topics: Acetylcysteine; Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Chloroquine; Excitatory Amino Acid Transporter 3; Humans; Leupeptins; Male; Morphine; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitin | 2008 |
TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes.
Topics: Acetylcysteine; Androstadienes; Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Survival; Chromones; Deferoxamine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Keratinocytes; Leupeptins; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Tocopherols; Tumor Necrosis Factor-alpha; Wortmannin | 2008 |
Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Inhibitors; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Naphthalimides; Proteasome Endopeptidase Complex; Protein Kinases; Thiophenes; Time Factors; Topoisomerase II Inhibitors; Ubiquitin | 2008 |
Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cysteine Proteinase Inhibitors; Leupeptins; MAP Kinase Signaling System; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Rats; Receptor, trkA; Ubiquitination | 2009 |
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylcysteine; Adenoviridae; Aldosterone; Animals; Biological Transport; Blotting, Western; Cysteine Proteinase Inhibitors; Glucose; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Leupeptins; Mice; Phosphorylation; Reactive Oxygen Species; Receptor, Insulin; Signal Transduction | 2009 |
Protective effect against Parkinson's disease-related insults through the activation of XBP1.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dopamine; Endoplasmic Reticulum; Endoribonucleases; Humans; Leupeptins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factors; X-Box Binding Protein 1 | 2009 |
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzazepines; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclin D1; Fibroblasts; Glioma; Hexanones; Humans; Hydrocarbons, Chlorinated; Indoles; Leupeptins; Mice; Peptide Fragments; Proteasome Inhibitors; Purines; Recombinant Fusion Proteins; Roscovitine; Threonine | 2009 |
Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion.
Topics: Acetylcysteine; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Embryo Implantation; Female; Humans; Hydatidiform Mole; Immunohistochemistry; In Vitro Techniques; Interleukin-1beta; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Placentation; Pregnancy; RNA Interference; Trophoblasts; Uterine Neoplasms | 2009 |
Role of oxidative stress in ischemia-reperfusion-induced alterations in myofibrillar ATPase activities and gene expression in the heart.
Topics: Acetylcysteine; Animals; Antioxidants; Calcium-Transporting ATPases; Cardiac Myosins; Catalase; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Leupeptins; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Myofibrils; Myosin Heavy Chains; Myosin Light Chains; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Ventricular Dysfunction, Left; Ventricular Pressure; Xanthine; Xanthine Oxidase | 2009 |
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.
Topics: Acetylcysteine; Activating Transcription Factor 6; Animals; Apolipoprotein B-100; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Glucosamine; Heat-Shock Proteins; Humans; Leupeptins; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; RNA; Signal Transduction; Time Factors | 2009 |
Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.
Topics: Acetylcysteine; Animals; Axons; Axotomy; Cells, Cultured; Cysteine Proteinase Inhibitors; Immunohistochemistry; Leupeptins; Neurofilament Proteins; Neurons; Phosphorylation; Physical Stimulation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Ubiquitin; Ubiquitination | 2009 |
Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antioxidants; Cell Line; Cysteine Proteinase Inhibitors; Dexamethasone; Dose-Response Relationship, Drug; Epithelial Cells; Glucocorticoids; Humans; Hydrogen Peroxide; Interferon Regulatory Factor-3; Interleukin-8; Leupeptins; Oxidants; Oxidative Stress; Poly I-C; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Respiratory Mucosa; RNA Interference; RNA, Double-Stranded; Time Factors; Toll-Like Receptor 3; Transcription Factor RelA; Up-Regulation | 2010 |
Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Heat Shock Transcription Factors; HSP30 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Proteasome Inhibitors; Temperature; Transcription Factors; Xenopus laevis | 2010 |
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Topics: Acetylcysteine; Apoptosis; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leupeptins; Lysosomes; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Serine-Threonine Kinases | 2010 |
The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.
Topics: Acetylcysteine; Animals; Binding Sites; Brefeldin A; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylation; Leupeptins; Membrane Transport Modulators; Protein Structure, Tertiary; Protein Transport; Quinones; Sequence Deletion; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sesquiterpenes; Structure-Activity Relationship; Transfection | 2009 |
Mechanical stretch enhances NF-kappaB-dependent gene expression and poly(ADP-ribose) synthesis in synovial cells.
Topics: Acetylcysteine; Animals; Cells, Cultured; Curcumin; Cyclooxygenase 2; Free Radical Scavengers; Gene Expression Regulation; Isoquinolines; Leupeptins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Piperidines; Poly Adenosine Diphosphate Ribose; Pyrrolidines; Rabbits; Stress, Mechanical; Structure-Activity Relationship; Synovial Membrane; Thiocarbamates | 2010 |
Reactive oxygen species and glutathione level changes by a proteasome inhibitor, MG132, partially affect calf pulmonary arterial endothelial cell death.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Cattle; Cell Culture Techniques; Cell Death; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Glutathione; Humans; Leupeptins; Membrane Potential, Mitochondrial; Proteasome Inhibitors; Pulmonary Artery; Reactive Oxygen Species | 2010 |
The changes of reactive oxygen species and glutathione by MG132, a proteasome inhibitor affect As4.1 juxtaglomerular cell growth and death.
Topics: Acetylcysteine; Animals; Apoptosis; Buthionine Sulfoximine; Caspase 3; Caspase 8; Cell Line, Tumor; Ditiocarb; Enzyme Inhibitors; G1 Phase; Glutathione; Juxtaglomerular Apparatus; Leupeptins; Membrane Potential, Mitochondrial; Mice; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2010 |
The effects of N-acetyl cysteine on the MG132 proteasome inhibitor-treated lung cancer cells in relation to cell growth, reactive oxygen species and glutathione.
Topics: Acetylcysteine; Apoptosis; Buthionine Sulfoximine; Cell Line, Tumor; Cell Proliferation; Ditiocarb; Glutathione; Humans; Leupeptins; Lung Neoplasms; Membrane Potential, Mitochondrial; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Reactive Oxygen Species | 2010 |
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.
Topics: Acetylcysteine; Apoptosis; Cell Culture Techniques; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Fibronectins; Humans; Leupeptins; Mutation; Peptide Fragments; Periodontal Ligament; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53; Ubiquitin | 2010 |
Attenuation of MG132-induced HeLa cell death by N-acetyl cysteine via reducing reactive oxygen species and preventing glutathione depletion.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle; Cell Proliferation; Glutathione; HeLa Cells; Humans; Leupeptins; Membrane Potential, Mitochondrial; Proteasome Inhibitors; Reactive Oxygen Species | 2010 |
Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase.
Topics: Acetylcysteine; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Isocitrate Dehydrogenase; Leupeptins; Mitochondrial Proteins; Phosphatidylinositol 3-Kinases; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sp1 Transcription Factor | 2010 |
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.
Topics: Acetylcysteine; Animals; Biological Assay; Boronic Acids; Bortezomib; Cell Extracts; Cells, Cultured; Chymotrypsin; High-Throughput Screening Assays; Inhibitory Concentration 50; Leupeptins; Mice; Models, Biological; Oligopeptides; Ornithine Decarboxylase; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Time Factors | 2011 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Line, Tumor; Cerebral Cortex; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lewy Bodies; Neurons; Okadaic Acid; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rabbits; Ubiquitin | 2010 |
Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.
Topics: Acetylcysteine; Aminopeptidases; Blotting, Western; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dose-Response Relationship, Drug; Drug Synergism; Enterovirus B, Human; Enzyme Inhibitors; HeLa Cells; Host-Pathogen Interactions; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine Endopeptidases; Virus Replication | 2011 |
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.
Topics: Acetylcysteine; Actins; Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Kidney Diseases; Leupeptins; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Ureteral Obstruction | 2011 |
Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication.
Topics: Acetylcysteine; Dengue Virus; Gene Knockdown Techniques; HeLa Cells; Humans; Leupeptins; Listeria monocytogenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Ubiquitin; Ubiquitin-Protein Ligases; Virus Internalization; Virus Replication; West Nile virus; Yellow fever virus | 2011 |
Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.
Topics: Acetylcysteine; Analgesics, Opioid; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Leupeptins; Naloxone; Narcotic Antagonists; Pertussis Toxin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-2; Receptors, Bradykinin; Receptors, Opioid, delta; Receptors, Opioid, mu; RGS Proteins; Signal Transduction; Time Factors; Ubiquitination | 2011 |
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.
Topics: Acetylcysteine; Amino Acid Substitution; Animals; Calcium Channels, N-Type; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Gene Expression Regulation; Leupeptins; Mutation, Missense; Nerve Tissue Proteins; Neurites; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Rats | 2011 |
Reactive oxygen species regulate nucleostemin oligomerization and protein degradation.
Topics: Acetylcysteine; Animals; Blast Crisis; Carrier Proteins; Cell Proliferation; Cell Transformation, Neoplastic; Cysteine Proteinase Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Leukemic; GTP-Binding Proteins; HL-60 Cells; Humans; Hydrogen Peroxide; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leupeptins; Lymphoma; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Neoplasms, Experimental; Nuclear Proteins; Oxidants; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Multimerization; Proto-Oncogene Proteins c-myc; RNA-Binding Proteins | 2011 |
Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.
Topics: Acetylcysteine; Actins; Animals; Binding Sites; Carotid Artery Injuries; Cells, Cultured; Chromatin Immunoprecipitation; Collagen; Cysteine Proteinase Inhibitors; Disease Models, Animal; DNA Polymerase II; Gels; Gene Expression Regulation; Genotype; Humans; Leupeptins; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Phosphorylation; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Serine; Serum Response Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Vasoconstriction | 2011 |
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
Topics: Acetylcysteine; Animals; Anthracenes; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Activation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin Receptor Substrate Proteins; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2011 |
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.
Topics: Acetylcysteine; Cell Culture Techniques; Cloning, Molecular; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Gene Expression; Immunoprecipitation; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Leupeptins; Methionine Adenosyltransferase; Oligopeptides; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; S-Adenosylmethionine; Transfection; Ubiquitin | 2011 |
Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Herpesvirus 8, Human; Humans; Leupeptins; Lymphoma, Primary Effusion; NF-kappa B; Nitriles; Oligopeptides; Proteasome Inhibitors; Sulfones; Virus Replication | 2011 |
Effects of proteasome inhibitors on the nucleolar size of porcine oocytes.
Topics: Acetylcysteine; Alpha-Amanitin; Animals; Cell Nucleolus; Cysteine Proteinase Inhibitors; Dactinomycin; Female; Leupeptins; Nuclear Proteins; Oocytes; Proteasome Inhibitors; Swine | 2012 |
Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.
Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Doxorubicin; HEK293 Cells; Humans; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Proteasome Endopeptidase Complex; Ubiquitin | 2011 |
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.
Topics: Acetylcysteine; Ammonium Chloride; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Gene Knockout Techniques; HEK293 Cells; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leupeptins; Lysosomes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Presenilin-1; Presenilin-2; Proteasome Inhibitors; Proteolysis; Receptor, Notch1; Transcription, Genetic; Transcriptional Activation; Ubiquitination | 2012 |
Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation.
Topics: Acetylcysteine; Amino Acid Substitution; CDC2 Protein Kinase; Cell Cycle Proteins; Dual-Specificity Phosphatases; Gene Expression; HeLa Cells; Humans; Leupeptins; Okadaic Acid; Peptide Fragments; Phosphoric Monoester Hydrolases; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Ubiquitin | 2012 |
High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.
Topics: Acetylcysteine; Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Resistance; Embryonic Stem Cells; Gene Expression Regulation, Developmental; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Mice; Oligopeptides; Pluripotent Stem Cells; Proteasome Inhibitors | 2012 |
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
Topics: Acetylcysteine; Adenocarcinoma; Adenosine Triphosphate; Alkaloids; Animals; Antineoplastic Agents; Apoptosis; Carbazoles; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Chaperonins; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Mice; Mice, Nude; Oxidative Stress; Pancreatic Neoplasms; Reactive Oxygen Species; Sulfhydryl Compounds | 2013 |
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Glucokinase; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leupeptins; Mice; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Single-Cell Analysis; Ubiquitin; Ubiquitination | 2013 |
N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Free Radical Scavengers; High-Throughput Screening Assays; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Neurons; Neuroprotective Agents; Proteasome Endopeptidase Complex; Protein Folding | 2013 |
Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Astrocytes; Connexin 43; Down-Regulation; Gap Junctions; JNK Mitogen-Activated Protein Kinases; Leupeptins; Lipopolysaccharides; NF-kappa B; Proteasome Endopeptidase Complex; Proteolysis; Rats; Signal Transduction; Ubiquitination; Ubiquitins | 2013 |
Enzyme enhancers for the treatment of Fabry and Pompe disease.
Topics: 1-Deoxynojirimycin; Acetylcysteine; alpha-Galactosidase; alpha-Glucosidases; Ambroxol; Bezafibrate; Enzyme Activators; Fabry Disease; Gene Expression; Glycogen Storage Disease Type II; HEK293 Cells; Humans; Leupeptins; Lysosomes; Pioglitazone; Plasmids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Recombinant Proteins; Thiazolidinediones; Transfection | 2015 |
Partial inhibition of the ubiquitin-proteasome system ameliorates cardiac dysfunction following ischemia-reperfusion in the presence of high glucose.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Autophagy; Diabetic Cardiomyopathies; Hyperglycemia; Inflammation Mediators; Isolated Heart Preparation; Leupeptins; Male; Myocardial Reperfusion Injury; Myocardium; Proteasome Inhibitors; Rats, Wistar; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors | 2015 |
The immobilization of human spermatozoa by STAT3 inhibitory compound V results from an excessive intracellular amount of reactive oxygen species.
Topics: Acetylcysteine; Acrosome Reaction; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Apoptosis; Calcium; Caspase Inhibitors; Cyclic S-Oxides; Humans; Leupeptins; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Proteasome Inhibitors; Reactive Oxygen Species; Sperm Motility; Spermatozoa; STAT3 Transcription Factor | 2016 |
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Autophagy; Autophagy-Related Protein 12; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Chloroquine; Dendritic Cells; Endocytosis; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class II; Humans; Immunotherapy, Adoptive; Leupeptins; Lymphocyte Activation; Lysosomal-Associated Membrane Protein 2; Melanoma; Membrane Proteins; RNA Interference; RNA, Small Interfering; Small Ubiquitin-Related Modifier Proteins | 2016 |
Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.
Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Glutathione; Hippocampus; HSP70 Heat-Shock Proteins; Leupeptins; Microtubule-Associated Proteins; Models, Neurological; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Proteasome Endopeptidase Complex; Rats, Sprague-Dawley; Stress, Physiological | 2016 |
The effect of peptidic and non-peptidic proteasome inhibitors on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype.
Topics: Acanthamoeba castellanii; Acetylcysteine; Bortezomib; Brain; Cell Adhesion; Cells, Cultured; Chlorhexidine; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Genotype; Humans; Lactones; Leupeptins; Proteasome Inhibitors | 2016 |
Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large-scale and targeted quantitative proteomics.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Bortezomib; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Ontology; Heat-Shock Proteins; Humans; Interleukins; Leukocytes; Leupeptins; Molecular Sequence Annotation; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Signal Transduction; Transcription Factors; Tumor Suppressor Protein p53 | 2017 |
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells.
Topics: Acetylcysteine; Carrier Proteins; Caspase 10; Free Radical Scavengers; Glutathione; HCT116 Cells; HSP90 Heat-Shock Proteins; HT29 Cells; Humans; Leukemia; Leupeptins; MCF-7 Cells; Protease Inhibitors; Proteolysis; Reactive Oxygen Species | 2017 |
Topics: Acetylcysteine; Animals; Astrocytes; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Female; Glutathione; HSP70 Heat-Shock Proteins; Leupeptins; Male; Protein Folding; Rats; Rats, Sprague-Dawley | 2017 |
Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Down-Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Insulin-Secreting Cells; Insulinoma; Islet Amyloid Polypeptide; Leupeptins; Mice; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2018 |
A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses.
Topics: Acetylcysteine; Alphavirus; Animals; Antiviral Agents; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Cytoplasm; HeLa Cells; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Vero Cells; Virus Replication | 2019 |
The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Ducks; Flavivirus; Gene Knockdown Techniques; Leupeptins; Poultry Diseases; Proteasome Endopeptidase Complex; RNA, Small Interfering; Transfection; Ubiquitin; Viral Envelope Proteins; Virus Internalization; Virus Replication | 2019 |
Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus.
Topics: Acetylcysteine; Animals; Autophagy; Cell Line, Tumor; Cell Nucleus; GPI-Linked Proteins; Humans; Leupeptins; Mice, Knockout; Models, Biological; Nerve Tissue Proteins; Neuroglia; Neurons; Prions; Promoter Regions, Genetic; Proteasome Inhibitors | 2019 |