acetylcysteine and leucine

acetylcysteine has been researched along with leucine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (29.63)18.2507
2000's16 (59.26)29.6817
2010's1 (3.70)24.3611
2020's2 (7.41)2.80

Authors

AuthorsStudies
Critchley, H; Davis, SS; Farraj, NF; Fisher, AN; Illum, L; Johansen, BR; O'Hagan, DT1
Lock, EA1
Lee, HW; Pettit, GR; Smith, JB; Smith, L; Vinitsky, A1
Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN1
Ancolio, K; Checler, F; da Costa, CA1
Hunter-Ensor, M; Naidoo, N; Sehgal, A; Song, W1
Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N1
Asuru, A; Boudjelal, M; Fisher, GJ; Kang, S; Li, XY; Peng, ZH; Voorhees, JJ; Xiao, JH1
Barbato, C; Calissano, P; Canu, N; Ciotti, MT; Dus, L; Serafino, A1
Bonvini, P; Hwang, SG; Li, Q; Mimnaugh, EG; Neckers, L; Reed, E; Trepel, J; Yunmbam, MK1
Choi, HJ; Han, HJ; Kim, JH; Lee, JH; Park, SH; Woo, CH1
Katunuma, N; Kito, M; Moriyama, T; Ogawa, T; Simoni, RD; Urade, R; Wada, M1
Hosoyama, Y; Miyata, S; Sekiguchi, T1
Andersson, R; Börjesson, A; Haraldsen, P; Lasson, A; Olanders, K; Sun, ZW1
Imai, K; Kunimatsu, M; Liu, ZQ; Manabe, T; Okamoto, T; Sasaki, M; Takeyama, H; Teranishi, F1
Jösch, C; Klotz, LO; Sies, H1
Andersson, R; Börjesson, A; Olanders, K; Sun, ZW1
Chan, P; Chen, JJ; Chen, YL; Cheng, CF; Cheng, TH; Huang, MT; Lin, H; Liu, JC; Shih, NL1
Bradbury, NA; Devor, DC; Hamilton, KL; Jones, HM; Papworth, GD; Syme, CA; Watkins, SC1
Andersen, CI; Bennett, RG; Berhanu, P; Duckworth, WC; Fawcett, J; Hamel, FG1
Ebihara, K; Fushiki, T; Hayashi, T; Hosoda, K; Inoue, G; Masuzaki, H; Miyamoto, L; Nakano, M; Nakao, K; Otaka, A; Sato, K; Tanaka, S; Toyoda, T; Yonemitsu, S1
Horta, MF; Ramalho-Pinto, FJ; Silva-Jardim, I1
Bermel, W; Chen, Z; Chevelkov, V; Reif, B1
Chen, Z; Hologne, M; Reif, B1
Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM1
Baum, SJ; Chakravarthy, MV; Chera, H; Gunn, NT; Harrison, SA; Kohli, A; Koziel, MJ; Patil, R; Younes, ZH; Zhao, J1
Mancini, L; Paolantoni, M; Ricci, M; Schoubben, A1

Trials

1 trial(s) available for acetylcysteine and leucine

ArticleYear
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease.
    The American journal of gastroenterology, 2021, 12-01, Volume: 116, Issue:12

    Topics: Acetylcysteine; Administration, Oral; Arginine; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Combinations; Drug Tolerance; Female; Glutamine; Humans; Isoleucine; Leucine; Liver; Magnetic Resonance Imaging; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Single-Blind Method; Treatment Outcome; Valine

2021

Other Studies

26 other study(ies) available for acetylcysteine and leucine

ArticleYear
Nasal absorption enhancers for biosynthetic human growth hormone in rats.
    Pharmaceutical research, 1990, Volume: 7, Issue:7

    Topics: Absorption; Acetylcysteine; Animals; Enzyme-Linked Immunosorbent Assay; Growth Hormone; Humans; Leucine; Lysophosphatidylcholines; Male; Mucus; Nasal Mucosa; Palmitoylcarnitine; Rats; Rats, Inbred Strains; Viscosity

1990
Piggy-back race.
    Human & experimental toxicology, 1995, Volume: 14, Issue:11

    Topics: Acetylcysteine; Animals; Binding, Competitive; Brain; Capillaries; Cells, Cultured; Cysteine; Endothelium, Vascular; Glutathione; Homocysteine; Leucine; Methylmercury Compounds; Penicillamine; Stereoisomerism; Sulfhydryl Compounds

1995
Ubiquitination of protein kinase C-alpha and degradation by the proteasome.
    The Journal of biological chemistry, 1996, Aug-30, Volume: 271, Issue:35

    Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Bryostatins; Cells, Cultured; Cysteine Endopeptidases; Cytosol; Down-Regulation; Hydrolysis; Isoenzymes; Lactones; Leucine; Macaca mulatta; Macrolides; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-alpha; Ubiquitins

1996
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
    Cardiovascular research, 1998, Volume: 38, Issue:3

    Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats

1998
C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
    Molecular medicine (Cambridge, Mass.), 1999, Volume: 5, Issue:3

    Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycopeptides; Humans; Leucine; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Pepstatins; Presenilin-1; Presenilin-2; Proteasome Endopeptidase Complex; Recombinant Proteins; Sulfones; Transfection

1999
A role for the proteasome in the light response of the timeless clock protein.
    Science (New York, N.Y.), 1999, Sep-10, Volume: 285, Issue:5434

    Topics: Acetylcysteine; Animals; Biological Clocks; Cells, Cultured; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Darkness; Drosophila; Drosophila Proteins; Feedback; Insect Proteins; Leucine; Leupeptins; Light; Multienzyme Complexes; Neurons; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitins

1999
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
    International journal of oncology, 1999, Volume: 15, Issue:4

    Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins

1999
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:10

    Topics: Acetylcysteine; Administration, Topical; Calcitriol; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Gene Expression Regulation; Humans; Keratinocytes; Leucine; Leupeptins; Multienzyme Complexes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Receptors, Calcitriol; Skin; Steroid Hydroxylases; Ubiquitins; Vitamin D3 24-Hydroxylase

1999
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-15, Volume: 20, Issue:2

    Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins

2000
Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors.
    Biochemical pharmacology, 2000, Nov-01, Volume: 60, Issue:9

    Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cells, Cultured; Chromatin; Cisplatin; Cysteine Endopeptidases; Cytosol; DNA; DNA Adducts; DNA Repair; DNA-Binding Proteins; Drug Interactions; Endonucleases; Enzyme Inhibitors; Female; Histones; Humans; Leucine; Multienzyme Complexes; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteins; RNA, Messenger; Ubiquitins

2000
High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.
    Kidney international, 2001, Volume: 59, Issue:5

    Topics: Acetylcysteine; Animals; Antioxidants; Cell Cycle; Cell Division; Cells, Cultured; Diabetic Nephropathies; Glucose; Kidney Tubules, Proximal; Leucine; Lipid Peroxides; Oxidative Stress; Protein Kinase C; Rabbits; Taurine; Thymidine; Transforming Growth Factor beta; Vitamin E

2001
3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.
    Archives of biochemistry and biophysics, 2001, Feb-15, Volume: 386, Issue:2

    Topics: Acetylcysteine; Animals; Cathepsin L; Cathepsins; Cell Extracts; Cell Line; Cell Membrane Permeability; Cricetinae; Cysteine Endopeptidases; Endopeptidases; Endoplasmic Reticulum; Epoxy Compounds; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Intracellular Membranes; Leucine; Lysosomes; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyridines; Sonication; Sterols

2001
Effects of proteasome inhibitor (lactacystin) and cysteine protease inhibitor (E-64-d) on processes of mitosis in Xenopus embryonic cells.
    Zoological science, 2002, Volume: 19, Issue:11

    Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Leucine; Mitosis; Signal Transduction; Xenopus

2002
Multimodal management - of value in fulminant acute pancreatitis?
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2003, Volume: 3, Issue:1

    Topics: Acetylcysteine; Acute Disease; Animals; Antibodies, Monoclonal; Capillary Permeability; Drug Therapy, Combination; Free Radical Scavengers; Imidazoles; Leucine; Male; Pancreatitis; Platelet Activating Factor; Platelet Endothelial Cell Adhesion Molecule-1; Rats; Rats, Sprague-Dawley

2003
Calpain is involved in the HIV replication from the latently infected OM10.1 cells.
    Biochemical and biophysical research communications, 2003, Apr-11, Volume: 303, Issue:3

    Topics: Acetylcysteine; Binding Sites; Calcimycin; Calcium Signaling; Calcium-Binding Proteins; Calpain; Cell Line; Glycoproteins; HIV-1; Humans; I-kappa B Proteins; In Vitro Techniques; Ionophores; Leucine; NF-kappa B; NF-KappaB Inhibitor alpha; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Virus Replication

2003
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
    Biological chemistry, 2003, Volume: 384, Issue:2

    Topics: Acetylcysteine; Animals; Antibodies; Cytosol; Dipeptides; Hydrolysis; Leucine; Leucyl Aminopeptidase; Liver; Precipitin Tests; Protease Inhibitors; Rats; Substrate Specificity; Swine

2003
Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats.
    Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:6

    Topics: Acetylcysteine; Animals; Cytoprotection; Free Radical Scavengers; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1; Intestinal Mucosa; Intestines; Ischemia; Leucine; Male; Neutrophil Infiltration; Permeability; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Reperfusion Injury

2003
Inhibitory effect of resveratrol on angiotensin II-induced cardiomyocyte hypertrophy.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 369, Issue:2

    Topics: Acetylcysteine; Angiotensin II; Animals; Animals, Newborn; Antioxidants; Cells, Cultured; Hypertrophy; Leucine; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Cardiac; Myosin Heavy Chains; Phosphorylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Resveratrol; Stilbenes; Transfection; Ventricular Myosins

2004
Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1.
    The Journal of biological chemistry, 2004, Apr-09, Volume: 279, Issue:15

    Topics: Acetylcysteine; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cell Membrane; Chloroquine; Dimerization; DNA, Complementary; Electrophysiology; Endocytosis; Epitopes; Humans; Immunoblotting; Intermediate-Conductance Calcium-Activated Potassium Channels; Leucine; Leucine Zippers; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Transport; Temperature; Time Factors

2004
Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.
    Journal of endocrinological investigation, 2003, Volume: 26, Issue:11

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Insulin; Leucine; Molecular Sequence Data; Mutation; Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Tyrosine

2003
Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle.
    American journal of physiology. Endocrinology and metabolism, 2004, Volume: 287, Issue:1

    Topics: Acetylcysteine; AMP-Activated Protein Kinases; Animals; Dose-Response Relationship, Drug; Glucose; Hydrogen Peroxide; In Vitro Techniques; Isoenzymes; Leucine; Male; Multienzyme Complexes; Muscle, Skeletal; Oxidative Stress; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley

2004
The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.
    Acta tropica, 2004, Volume: 91, Issue:2

    Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Leishmania; Leishmaniasis, Visceral; Leucine; Macrophages, Peritoneal; Male; Mice; Multienzyme Complexes; Oligopeptides; Phenylmethylsulfonyl Fluoride; Proteasome Endopeptidase Complex

2004
Resolution enhancement in MAS solid-state NMR by application of 13C homonuclear scalar decoupling during acquisition.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 2005, Volume: 172, Issue:1

    Topics: Acetylcysteine; Amino Acids; Carbon Isotopes; Leucine; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Peptides; Signal Processing, Computer-Assisted; Valine

2005
Characterization of dynamic processes using deuterium in uniformly 2H,13C,15N enriched peptides by MAS solid-state NMR.
    Journal of magnetic resonance (San Diego, Calif. : 1997), 2006, Volume: 179, Issue:1

    Topics: Acetylcysteine; Carbon Isotopes; Deuterium; Leucine; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Peptides; Signal Processing, Computer-Assisted; Valine

2006
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
    Oncogene, 2011, Feb-17, Volume: 30, Issue:7

    Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin

2011
Development of spray-dried N-acetylcysteine dry powder for inhalation.
    International journal of pharmaceutics, 2023, Jan-25, Volume: 631

    Topics: Acetylcysteine; Administration, Inhalation; Aerosols; Dry Powder Inhalers; Leucine; Mannitol; Particle Size; Powders

2023