acetylcysteine has been researched along with lactacystin in 886 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 178 (20.09) | 18.2507 |
| 2000's | 536 (60.50) | 29.6817 |
| 2010's | 168 (18.96) | 24.3611 |
| 2020's | 4 (0.45) | 2.80 |
| Authors | Studies |
|---|---|
| Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N | 1 |
| Fujimoto, T; Matsuzaki, K; Moriguchi, R; Omura, S; Otoguro, K; Sasaki, Y; Tanaka, H | 1 |
| Fujimoto, T; Fujita, S; Furuya, T; Kosuge, K; Matsuzaki, K; Nakagawa, A; Omura, S | 1 |
| Arima, S; Inokoshi, J; Katagiri, M; Matsuzaki, K; Omura, S; Tanaka, H | 1 |
| Mori, S; Omura, S; Saito, Y; Tanaka, K | 1 |
| Goldberg, AL; Jensen, TJ; Loo, MA; Pind, S; Riordan, JR; Williams, DB | 1 |
| Kainosho, M; Matsuzaki, K; Miyake, Y; Nakagawa, A; Omura, S; Takahashi, S; Uchida, K | 1 |
| Arima, S; Matsuzaki, K; Nagamitsu, T; Obata, R; Omura, S; Stump, H; Sunazuka, T; Tanaka, H | 1 |
| Choi, S; Corey, EJ; Fenteany, G; Lane, WS; Schreiber, SL; Standaert, RF | 1 |
| Hayashi, M; Katagiri, M; Matsuzaki, K; Omura, S; Tanaka, H | 1 |
| Corey, EJ; Fenteany, G; Reichard, GA; Schreiber, SL; Standaert, RF | 1 |
| Osda, H | 1 |
| Kanaki, H; Mori, S; Morisaki, N; Saito, Y; Tanaka, K | 1 |
| Imajoh-Ohmi, S; Kawaguchi, T; Kikuchi, H; Omura, S; Sugiyama, S; Tanaka, K | 1 |
| Cruikshank, AA; Dick, LR; Grenier, L; Melandri, FD; Nunes, SL; Stein, RL | 1 |
| Ikehara, Y; Oda, K; Omura, S | 1 |
| Howley, PM; Huibregtse, JM; Maki, CG | 1 |
| Goldberg, AL; Grimm, LM; Osborne, BA; Poirier, GG; Schwartz, LM | 1 |
| Becherer, JD; Fernandez, PA; Irmler, M; Maki, M; Martinou, I; Martinou, JC; Quiquerez, AL; Sadoul, R; Schröter, M; Tschopp, J | 1 |
| Hachiya, T; Kitamura, K; Miyazaki, T; Naoe, T; Ohno, R; Omura, S; Tanaka, K; Yoshida, H | 1 |
| Hayashi, S; Murakami, Y; Omura, S; Tanahashi, N; Tanaka, K | 1 |
| Lee, HW; Pettit, GR; Smith, JB; Smith, L; Vinitsky, A | 1 |
| Omura, S; Takeshima, H | 1 |
| Omura, S; Perlmutter, DH; Qu, D; Teckman, JH | 1 |
| Chavany, C; Mimnaugh, EG; Neckers, L | 1 |
| Cheng, HH; Kumagai, H; McGee, TP; Omura, S; Simoni, RD | 1 |
| Blagosklonny, MV; el-Deiry, WS; Omura, S; Wu, GS | 1 |
| Miura, H; Miura, K; Omura, S; Takishima, K; Tomoda, H | 1 |
| Goldberg, AL; Lee, DH | 2 |
| Corey, EJ; Frevert, U; Ghiso, J; González, J; Nussenzweig, V; Ramalho-Pinto, FJ; Scharfstein, J; Tomlinson, S | 1 |
| Fenteany, G; Schreiber, SL | 2 |
| Brodsky, JL; McCracken, AA; Werner, ED | 1 |
| Darnell, JE; Haspel, RL; Salditt-Georgieff, M | 1 |
| Cruikshank, AA; Destree, AT; Dick, LR; Grenier, L; McCormack, TA; Melandri, FD; Nunes, SL; Palombella, VJ; Parent, LA; Plamondon, L; Stein, RL | 1 |
| Jeffers, M; Omura, S; Taylor, GA; Vande Woude, GF; Weidner, KM | 1 |
| Benham, A; Braud, V; Cerundolo, V; Gould, K; Macino, B; Mukherjee, S; Neefjes, J; Townsend, A | 1 |
| Fujita, K; Omura, S; Silver, J | 1 |
| Cresswell, P; Hammond, C; Hughes, EA | 1 |
| Lee, HW; Pettit, GR; Smith, JB; Smith, L | 1 |
| Bush, KT; Goldberg, AL; Nigam, SK | 1 |
| Bartunik, HD; Bochtler, M; Ditzel, L; Groll, M; Huber, R; Löwe, J; Stock, D | 1 |
| Roberts, BJ | 1 |
| Bokkala, S; Joseph, SK | 1 |
| Akopian, T; Craiu, A; Fenteany, G; Gaczynska, M; Goldberg, AL; Gramm, CF; Rock, KL | 1 |
| Jones, SN; Kubbutat, MH; Vousden, KH | 1 |
| Omura, S; Ostrowska, H; Wojcik, C; Worowski, K | 1 |
| An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L | 1 |
| Haass, C; Ihara, Y; Omura, S; Saido, TC; Yamazaki, T | 1 |
| Cui, H; Ju, ST; Matsui, K; Matulka, RA; Omura, S; Schauer, SL; Sonenshein, GE | 1 |
| Baumeister, W; Eichmann, K; Gartmann, C; Geier, E; Grimm, R; Maurer, M; Niedermann, G; Omura, S; Realini, C; Rechsteiner, MC; Soll, J | 1 |
| Ghosh, S; Phillips, RJ | 1 |
| Mellgren, RL | 2 |
| Huppa, JB; Ploegh, HL | 1 |
| Allport, JR; Collins, T; Ding, H; Gerritsen, ME; Luscinskas, FW | 1 |
| Hara, K; Koide, T; Kozuki, D; Omura, S; Shirotani, H; Tokunaga, F | 1 |
| Chang, YC; Heintz, NH; Illenye, S; Magae, J; Mitsui, Y; Omura, S; Tanaka, K; Tejima, T | 1 |
| Kakiuchi, T; Kominami, E; Mizuochi, T; Muno, D; Ogasawara, K; Okada, Y; Omura, S; Takatsuki, A; Yee, ST | 1 |
| Bai, A; Forman, J | 1 |
| Dritschilo, A; Soldatenkov, VA | 1 |
| Bellas, RE; Fausto, N; FitzGerald, MJ; Sonenshein, GE | 1 |
| Cui, H; Ju, ST; Matsui, K; Omura, S; Schauer, SL; Sonenshein, GE | 1 |
| Arora, N; Berzofsky, JA; Goletz, TJ; Keith, JM; Klimpel, KR; Leppla, SH | 1 |
| Breitschopf, K; Ciechanover, A; Gautschi, I; Ishikawa, T; Rotin, D; Schild, L; Staub, O | 1 |
| Choi, YH; Henkart, PA; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, P; Takano, E; Trepel, JB; Wu, ML | 1 |
| Folco, EJ; Koren, G | 1 |
| Ozols, J | 1 |
| Checler, F; Lopez-Perez, E; Marambaud, P; Wilk, S | 1 |
| Celis, JE; Chen, HY; Davie, JR; Mimnaugh, EG; Neckers, L | 1 |
| Bagchi, S; Berezutskaya, E; Morozov, A; Raychaudhuri, P; Yu, B | 1 |
| Fischer, JE; Hasselgren, PO; Hobler, SC; Monaco, J; Tiao, G | 1 |
| Biber, J; Lederer, E; Murer, H; Pfister, MF; Ruf, I; Stange, G; Ziegler, U | 1 |
| Hyun, WC; Mutomba, MC; To, WY; Wang, CC | 1 |
| Gabai, VL; Meriin, AB; Sherman, MY; Shifrin, VI; Yaglom, J | 1 |
| Antón, LC; Bacík, I; Bennink, JR; Bour, S; Cox, JH; Orlowski, M; Schubert, U; Strebel, K; Yewdell, JW | 1 |
| Bonvini, P; Neckers, LM; Nguyen, P; Trepel, J | 1 |
| Cai, H; Singh, I; Wagner, BJ | 1 |
| Del Val, M; López, D | 1 |
| Chen, H; Duguid, W; Luo, H; Wang, X; Wu, J | 1 |
| Arenzana-Seisdedos, F; Friguet, B; Heard, JM; Maréchal, V; Schwartz, O | 1 |
| Ancolio, K; Checler, F; Lopez-Perez, E; Marambaud, P | 1 |
| Binet, JL; Cosset, JM; Delic, J; Dumont, J; Magdelénat, H; Masdehors, P; Omura, S | 1 |
| Field, MC; Nesbeth, DN; Wainwright, LJ; Wilbourn, B | 1 |
| Alkon, DL; Favit, A; Grimaldi, M; Nelson, TJ | 1 |
| Calautti, E; Di Cunto, F; Dotto, GP; Hsiao, J; Ong, L; Seth, PK; Topley, G | 1 |
| Alderson, MR; Briden, AL; Grabstein, KH; Lewinsohn, DM; Reed, SG; Riddell, SR | 1 |
| Antón, LC; Bennink, JR; Orlowski, M; Porgador, A; Snyder, HL; Vinitsky, A; Yewdell, JW | 1 |
| Fernandez, PA; Martinou, I; Martinou, JC; Missotten, M; Sadoul, R | 1 |
| Nakamura, M; Oikawa, T; Omura, S; Sasaki, T; Shimamura, M; Tanahashi, N; Tanaka, K | 1 |
| Adeli, K; Gapor, A; Theriault, A; Wang, Q | 1 |
| Keller, SH; Lindstrom, J; Taylor, P | 1 |
| Colella, TA; Crotzer, VL; Engelhard, VH; Hunt, DF; King, GM; Luckey, CJ; Maier, BF; Marto, JA; Shabanowitz, J; Venketeswaran, S | 1 |
| Bercovich, B; Ciechanover, A; Gross-Mesilaty, S; Kahana, C; Reinstein, E; Schwartz, AL; Tobias, KE | 1 |
| Mutomba, MC; Wang, CC | 1 |
| Calafat, J; Dusseljee, S; Janssen, H; Neefjes, J; Tulp, A; Verwoerd, D; Wubbolts, R | 1 |
| Fang, CH; Fischer, JE; Hasselgren, PO; Hobler, S; Li, BG; Wang, JJ | 1 |
| Bentley, GV; Grisanti, MS; Murray, EJ; Murray, SS | 1 |
| Goltzman, D; Meerovitch, K; Wing, S | 1 |
| Elce, J; Forsberg, NE; Huang, J; Ichihara, A; Ou, BR; Tanaka, K; Ueda, Y; Wang, MC | 1 |
| McGee, TP; Moriyama, T; Sather, SK; Simoni, RD | 1 |
| Bennett, MJ; Kearse, KP; Van Leeuwen, JE | 1 |
| de Moissac, D; Greenberg, AH; Kirshenbaum, LA; Mustapha, S | 1 |
| Howley, PM; Kwon, YT; Patrick, GN; Tsai, LH; Zhou, P | 1 |
| Fisher, EA; Ginsberg, HN; Zhou, M | 1 |
| Chung, CH; Kang, MS; Kim, HS; Kim, JH; Kim, SS; Lee, KH; Rhee, S | 1 |
| Fukuchi, K; Gomi, K; Nakamaki, T; Tomoyasu, S; Tsuruoka, N | 1 |
| Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
| Deeg, M; Dick, TP; Groll, M; Heinemeyer, W; Huber, R; Keilholz, W; Nussbaum, AK; Rammensee, HG; Schild, H; Schirle, M; Stevanović, S; Wolf, DH | 1 |
| Briones, MR; Corey, EJ; Gantt, SM; Li, WD; Myung, JM; Nussenzweig, V; Omura, S; Sinnis, P | 1 |
| Chan, L; Liao, W; Yeung, SC | 1 |
| Baumeister, W; De Mot, R; Nagy, I; Tamura, T; Vanderleyden, J | 1 |
| Bai, A; Broen, J; Forman, J | 1 |
| Chrétien, S; Gisselbrecht, S; Lacombe, C; Mayeux, P; Muller, O; Varlet, P; Verdier, F; Yoshimura, A | 1 |
| Levine, L | 4 |
| Gallimore, A; Groettrup, M; Hengartner, H; Schwarz, K; van den Broek, M | 1 |
| Di Sano, F; Oliverio, S; Piacentini, M; Spinedi, A | 1 |
| Braulke, T; Breuer, P | 1 |
| Deeg, M; Dick, TP; Pömmerl, B; Rammensee, HG; Schild, H; Stoltze, L | 1 |
| Grune, T; Merker, K; Sitte, N | 1 |
| Ivanov, VN; Nikolić-Zugić, J | 1 |
| Honda, T; Mercken, M; Murayama, M; Murayama, O; Nihonmatsu, N; Omori, A; Saido, TC; Sato, K; Takahashi, H; Takashima, A; Tsubuki, S; Yasutake, K | 1 |
| Andersson, M; Karlsson, JO; Kling-Petersen, A; Sjöstrand, J | 1 |
| Giermasz, A; Gołab, J; Stokłosa, T; Wilk, S; Wójcik, C | 1 |
| Orrenius, S; Pörn-Ares, MI; Samali, A | 1 |
| Fujiwara, T; Honda, Y; Mugita, N; Nakamura, H; Nakao, M; Ogawa, M; Omura, S; Saya, H; Shimbara, N; Tanaka, K | 1 |
| Adams, J; Brand, S; Conner, EM; Destree, A; Elliott, PJ; Grisham, MB; Mazzola, LM; Palombella, VJ; Parent, L; Pien, C; Wong, HL | 1 |
| Kim, D; Kim, SH; Li, GC | 1 |
| Guerra, B; Lanford, RE; Wang, J; White, AL | 1 |
| Baumeister, W; Eichmann, K; Geier, E; Lucchiari-Hartz, M; Niedermann, G; Pfeifer, G; Wilm, M | 1 |
| Corey, EJ; Li, WD | 1 |
| Dennis, AP; Lonard, DM; Nawaz, Z; O'Malley, BW; Smith, CL | 1 |
| Chai, Y; Koppenhafer, SL; Paulson, HL; Perez, MK; Shoesmith, SJ | 1 |
| Cerottini, JC; Cerundolo, V; Dunbar, PR; Gileadi, U; Lévy, F; Romero, P; Servis, C; Valmori, D | 1 |
| Nakagawa, K; Tamai, K; Taya, Y; Yamaizumi, M | 1 |
| Choi, YH; Henkart, PA; Hwang, SG; Jang, JS; Lee, J; Lee, SJ; Maki, M; Nguyen, PM; Takano, E; Trepel, JB; Wu, ML | 1 |
| Alexander, JS; Cockrell, A; Grisham, MB; Ichikawa, H; Kalogeris, TJ; Laroux, FS; Okayama, N; Phifer, TJ | 1 |
| Chen, BD; Chen, C; Lin, H; Zhang, XM | 1 |
| Mulligan-Kehoe, MJ; Russo, A | 1 |
| Mahaffey, D; Rechsteiner, M | 1 |
| Cosset, JM; Delic, J; Dumont, J; Magdelénat, H; Masdehors, P; Mentz, F; Merle-Béral, H; Omura, S | 1 |
| Booth, BL; Cerundolo, V; Flavin, FM; Gileadi, U; Phillips, RE; Price, DA; Sewell, AK; Teisserenc, H; Trowsdale, J | 1 |
| Banks, L; Mantovani, F | 1 |
| Eble, DM; Ferguson, AG; Samarel, AM; Spragia, ML | 1 |
| Andersson, M; Karlsson, JO; Sjöstrand, J | 1 |
| Irie, S; Katagiri, K; Katagiri, T; Kawashima, S; Kinashi, T; Tanaka, K; Yokosawa, H | 1 |
| Affaitati, A; Avvedimento, EV; Cariello, L; de Cristofaro, T; Varrone, S | 1 |
| Friedberg, EC; Huang, W; Johnston, SA; Reed, SH; Russell, SJ | 1 |
| Ancolio, K; Checler, F; da Costa, CA | 1 |
| Hojo, K; Nishida, K; Omi, K; Omura, S; Sonoda, H; Sugita, K | 1 |
| Cardozo, C; Michaud, C; Orlowski, M | 1 |
| Adeli, K; Cavallo, D; Macri, J; Mohammadi, A; Rudy, D | 1 |
| Coux, O; Doo, E; Goldberg, AL; Hu, Z; Liang, TJ; Zhang, Z | 1 |
| Boulaire, J; Cannella, D; Fitzgerald, P; Fotedar, A; Fotedar, R; Rousseau, D | 1 |
| Redman, C; Xia, H | 1 |
| Fukuchi, K; Gomi, K; Maruyama, H; Takagi, Y | 1 |
| Nigam, SK; Tsukamoto, T | 1 |
| Baldin, V; Brichese, L; Chadebech, P; Valette, A; Vidal, S | 1 |
| Hunter-Ensor, M; Naidoo, N; Sehgal, A; Song, W | 1 |
| Gnegy, ME; McGinnis, KM; Mukerjee, N; Park, YH; Wang, KK | 1 |
| Bai, G; Corey, EJ; Eichinger, D; Frevert, U; Gonzalez, J | 1 |
| Asakura, T; Hashizume, Y; Ohkawa, K; Okawa, Y; Sawai, T; Takada, K; Yanaihara, N | 1 |
| Eitel, K; Hermisson, M; Wagenknecht, B; Weller, M | 1 |
| Clarke, DM; Loo, TW | 1 |
| Cederbaum, AI; Goasduff, T | 1 |
| Darnell, BF; Grammer, AC; Heaney, J; Lipsky, PE; McFarland, RD | 1 |
| Robertson, CD | 1 |
| Asuru, A; Boudjelal, M; Fisher, GJ; Kang, S; Li, XY; Peng, ZH; Voorhees, JJ; Xiao, JH | 1 |
| Abrahem, A; Certad, G; Georges, E | 1 |
| Kim, D; Li, GC | 1 |
| Choi, YH; Jang, JS | 1 |
| Banerjee, P; Ettenberg, SA; Keane, MM; Lipkowitz, S; Nau, MM; Rubinstein, YR | 1 |
| Chi, CX; Jiang, Y; Rom, WN; Tchou-Wong, KM; Yie, TA | 1 |
| Biswal, SS; Datta, K; Kehrer, JP; Robertson, JD | 1 |
| Olsnes, S; Rapak, A; Wesche, J | 1 |
| Mertz, K; Morgan, JI; Schmidt, J | 1 |
| Amara, SG; Daniels, GM | 1 |
| Guroff, G; Hashimoto, K; Katagiri, Y | 1 |
| Barbato, C; Calissano, P; Canu, N; Ciotti, MT; Dus, L; Serafino, A | 1 |
| Alves dos Santos, CM; Govers, R; Strous, GJ; van Kerkhof, P | 1 |
| Eichmann, K; Lauvau, G; Lucchiari-Hartz, M; Maier, R; Mann, D; Meyerhans, A; Niedermann, G; van Endert, PM | 1 |
| Chillarón, J; Haas, IG | 1 |
| Al-Katib, AM; Mohammad, RM; Reddy, KB; Wall, NR | 1 |
| Doms, RW; Lee, VM; Pijak, DS; Skovronsky, DM | 1 |
| Kanaan, N; Luo, H; Wu, J; Wu, Y | 1 |
| Carpino, N; Feng, J; Ihle, JN; Marine, JC; Moriggl, R; Stravopodis, D; Teglund, S; Wang, D | 1 |
| Horwitz, KB; Lange, CA; Shen, T | 1 |
| Hudson, E; Resau, JH; Taylor, GA; Vande Woude, GF | 1 |
| Accavitti-Loper, MA; Bingham Smith, J; Chen, L; Omura, S; Smith, L | 1 |
| Ambudkar, SV; Dey, S; Gribar, JJ; Hrycyna, CA; Ramachandra, M | 1 |
| Kaufman, RJ; Tagliavacca, L; Wang, Q | 1 |
| Adamo, AM; Besio Moreno, M; Pasquini, JM; Pasquini, LA; Soto, EF | 1 |
| Carmichael, J; Furlong, RA; Narain, Y; Rankin, J; Rubinsztein, DC; Swartz, J; Wyttenbach, A | 1 |
| Higasa, T; Kito, M; Kusunose, M; Moriyama, T; Urade, R | 1 |
| Borrelli, MJ; Domann, FE; Freeman, ML; Meredith, MJ; Sekhar, KR; Soltaninassab, SR; Xu, ZQ | 1 |
| Kaneda, T; Kudo, Y; Miyauchi, M; Nikai, H; Ogawa, I; Sato, S; Takata, T; Takekoshi, T; Zhao, M | 1 |
| Fayadat, L; Franc, JL; Lanet, J; Siffroi-Fernandez, S | 1 |
| Amsterdam, A; Dantes, A; Dekel, N; Galiani, D; Josefsberg, LB | 1 |
| Grune, T; Reinheckel, T; Sitte, N; Ullrich, O | 1 |
| Chen, HJ; Hwang, J; Hwong, CL; Wang, CH | 1 |
| Androlewicz, MJ; Wang, Y | 1 |
| Grommé, M; Neefjes, J; Reits, EA; Vos, JC | 1 |
| Goldberg, AL; Lecker, S; O'Connor, CM; Szymanska, G; Tarcsa, E | 1 |
| Cohen, GM; Dickens, M; MacFarlane, M | 1 |
| Adams, J; Chau, V; Elliott, PJ; Lightcap, ES; McCormack, TA; Pien, CS | 1 |
| Bergmann, C; Del Val, M; Gil-Torregrosa, BC; López, D | 1 |
| Lei, S; Ogiso, Y; Omura, S; Tomida, A; Tsuruo, T | 1 |
| Karlsson, JO; Lundquist, J; Nilsson, M; Skoglund, I | 1 |
| Feinstein, DL; Gavrilyuk, V; Horvath, P; Selmaj, K; Sharp, A; Stasiolek, M | 1 |
| Masse, CE; Morgan, AJ; Panek, JS | 1 |
| Crews, CM; de Giuli, R; Groettrup, M; Kim, KB; Kostka, S; Kraft, R; Schmidtke, G; Schwarz, K; van den Broek, M | 1 |
| Chang, D; Chen, F; Goh, M; Klibanov, SA; Ljungman, M | 1 |
| Egawa, K; Haruta, T; Kawahara, J; Kobayashi, M; Olefsky, JM; Sharma, PM; Takano, A; Uno, T | 1 |
| Kozlowski, L; Omura, S; Ostrowska, H; Radziwon, P; Stoklosa, T; Wilk, S; Wójcik, C; Worowski, K | 1 |
| Huang, FF; Keller, JN; Markesbery, WR | 1 |
| Burri, L; Heberer, M; Lévy, F; Lüscher, U; Noppen, C; Remmel, E; Schaefer, C; Spagnoli, GC; Zajac, P | 1 |
| Bohrn, E; Herceg, Z; Wang, ZQ; Wesierska-Gadek, J; Wurzer, G | 1 |
| Hata, T; Hayashibara, T; Honda, M; Joh, T; Kamihira, S; Maeda, T; Miyazaki, Y; Mori, N; Nohda, K; Sugahara, K; Tawara, M; Tomonaga, M; Tsuruda, K; Yamada, Y | 1 |
| Einarson, MB; Fashena, SJ; Golemis, EA; Law, SF; O'Neill, GM | 1 |
| Bamford, R; Hanover, JA; Kurys, G; Tagaya, Y; Waldmann, TA | 1 |
| Delic, J; Magdelénat, H; Maloum, K; Masdehors, P; Merle-Béral, H; Omura, S | 1 |
| Quievryn, G; Zhitkovich, A | 1 |
| An, WG; Blagosklonny, MV; Hwang, SG; Trepel, JB | 1 |
| Alkon, DL; Favit, A; Grimaldi, M | 1 |
| Andersson, M; Honarvar, AK; Karlsson, JO; Petersen, A; Sjöstrand, J | 1 |
| Davie, JR; Lucktong, A; Melkoumian, ZK; Moniwa, M; Strobl, JS; Zhou, Q | 1 |
| Aksenov, ND; Kislyakova, TV; Malashicheva, AB; Osipov, KA; Pospelov, VA | 1 |
| Camps, M; Kloetzel, PM; Melief, C; Offringa, R; Ossendorp, F; Sijts, A | 1 |
| Delic, J; Magdelénat, H; Masdehors, P; Merle-Béral, H | 1 |
| Adotevi, O; Amigorena, S; Bismuth, E; Bosset, S; Desaymard, C; Fridman, WH; Goud, B; Haicheur, N; Johannes, L; Lacabanne, V; Regnault, A; Ricciardi-Castagnoli, P; Tartour, E; Warnier, G | 1 |
| French, OG; Hahn, CS; Kang, BS; Sando, JJ | 1 |
| Hilbi, H; Puro, RJ; Zychlinsky, A | 1 |
| Alving, CR; Rao, M; Rothwell, SW; Wassef, NM | 1 |
| Masaki, R; Ohtani-Kaneko, R; Saito, T; Yamada, K | 1 |
| Bonvini, P; Hwang, SG; Li, Q; Mimnaugh, EG; Neckers, L; Reed, E; Trepel, J; Yunmbam, MK | 1 |
| Bartolazzi, A; Brodin, B; Dricu, A; Girnita, A; Girnita, L; Larsson, O; Lundeberg, J; Nilsson, G; Wejde, J; Wiman, KG; Xie, Y | 1 |
| Malek, TR; Yu, A | 1 |
| Klein, DC; Korf, HW; Laedtke, E; Schomerus, C; Weller, JL | 1 |
| Chang, KA; Choi, SH; Geum, DH; Jeong, SJ; Kim, HS; Kim, K; Lee, JH; Lee, SG; Park, CH; Rah, JC; Seo, JH; Suh, YH | 1 |
| Das, KC | 1 |
| Hauptmann, S; Leclere, A; Naujokat, C; Possinger, K; Sezer, O; Zinke, H | 1 |
| Cowan, M; Gladwin, MT; Grant, LR; Huang, XL; Logun, C; Schneider, R; Shelhamer, JH; Yao, XL | 1 |
| Groscurth, P; Hermisson, M; Krammer, PH; Liston, P; Wagenknecht, B; Weller, M | 1 |
| Omura, S; Tomoda, H | 1 |
| He, CY; Roos, DS; Shaw, MK; Tilney, LG | 1 |
| Chau, V; Patnaik, A; Wills, JW | 1 |
| Kayano, T; Kubota, H; Kurimoto, M; Ohta, T; Yanagi, H; Yokota, S; Yura, T | 1 |
| Jenner, P; McNaught, KS | 1 |
| Demura, T; Endo, S; Fukuda, H | 1 |
| Chang, C; Derynck, R; Gehling, DJ; Hemmati-Brivanlou, A; Zhang, Y | 1 |
| Mori, M; Sergeev, I; Terada, K; Wright, G; Yano, M | 1 |
| de Diego, JL; González, J; Gutiérrez, B; Katz, JM; Manning, JE; Marshall, P; Nussenzweig, V | 1 |
| Chan, L; Liao, W | 1 |
| Bertrand, R; Chinnadurai, G; Duguid, W; Kanaan, N; Luo, H; Marshansky, V; Vu, MD; Wang, X; Wu, J | 1 |
| Ostrand-Rosenberg, S; Qi, L | 1 |
| Furuta, K; Hanada, S; Harada, M; Kawaguchi, T; Kim, M; Kimura, R; Koga, H; Sakisaka, S; Sata, M; Suganuma, T; Sugiyama, T; Taniguchi, E; Terada, K | 1 |
| Kanaan, N; Luo, H; Wu, J | 1 |
| AbdulKarim, B; Bourhis, J; Deutsch, E; Dugray, A; Eschwege, F; M'Kacher, R; Maggiorella, L; Marangoni, E; Rasy, SD; Turhan, AG; Vaganay, S; Vainchenker, W | 1 |
| Grant, S; Vrana, JA | 1 |
| Baumann, CT; Hager, GL; Lim, C; Ma, H; Maruvada, P; Reyes, JC; Stallcup, MR; Wolford, R; Yen, PM | 1 |
| Goldenberg, GJ; Lam, V; McPherson, JP; Salmena, L | 1 |
| Hsueh, CT; Schwartz, GK; Wu, YC | 1 |
| Dawson, TM; Engelender, S; Igarashi, S; L Dawson, V; Rao, RK; Ross, CA; Sawa, A; Tanaka, Y; Tanzi, RE; Wanner, T | 1 |
| Eissa, NT; Musial, A | 1 |
| Lemoine, NR; Marani, M; McNeish, I; Tenev, T | 1 |
| Davies, KJ; Demasi, M; Shringarpure, R | 1 |
| Corey, EJ; Crane, SN | 1 |
| Kawamura, Y; Kikuchi, A; Komano, H; Shibamoto, S; Sudoh, S; Takada, R; Takada, S; Yanagisawa, K | 1 |
| Edidin, M; Pentcheva, T | 1 |
| Dautry-Varsat, A; Lamaze, C; Rocca, A; Subtil, A | 1 |
| Boeddrich, A; Lehrach, H; Lueder, G; Lurz, R; Scherzinger, E; Waelter, S; Wanker, EE | 1 |
| Joseph, SK; Khan, MT | 1 |
| Katunuma, N; Kito, M; Moriyama, T; Ogawa, T; Simoni, RD; Urade, R; Wada, M | 1 |
| Gieche, J; Grune, T; Klotz, LO; Rudeck, M; Sies, H | 1 |
| Bence, NF; Kopito, RR; Sampat, RM | 1 |
| Allen, PL; Benses, EN; Hammond, TG; Kaysen, JH; Saban, R; Wang, XC | 1 |
| Adler, G; Böhm, BO; Dralle, H; Hoang-Vu, C; Kessler, H; Ludwig, L; Schmid, RM; Wagner, M | 1 |
| Grdina, DJ; Hallahan, DE; Kataoka, Y; Murley, JS; Roberts, JC | 1 |
| Broker, TR; Chien, WM; Chow, LT; Noya, F | 1 |
| Akahane, K; Minami, M; Ramesh, M; Sharma, VM; Venkateswarlu, A | 1 |
| Cullen, P; Engel, T; Lorkowski, S; Wenner, C | 1 |
| Béchet, DM; Ferrara, M; Obled, A; Omura, S; Roux, MP; Tournu, C | 1 |
| Clague, MJ; Hammond, DE; Urbé, S; Vande Woude, GF | 1 |
| Baqui, MM; Bianco, AC; Curcio, C; Harney, JW; Larsen, PR; Mohr, S; Rihn, BH; Salvatore, D | 1 |
| Khanna, R; Lainé, M; Myers, MP; Papazian, DM | 1 |
| Carbonetti, NH; Lewis, GK; Tuskan, RG | 1 |
| Halliwell, B; Hyun, DH; Jenner, P; Lee, MH | 1 |
| Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Takano, A; Uno, T; Usui, I | 1 |
| Drahushuk, KM; Guo, X; Higgins, D; Horbinski, C; Kaplan, PL; Kim, IJ; Lein, P; Lin, Y; Wang, T | 1 |
| Hattori, N; Imai, Y; Inoue, H; Mizuno, Y; Soda, M; Takahashi, R | 1 |
| Mezey, E; Potter, JJ; Rennie-Tankersley, L | 1 |
| Ito, N; Kamada, H; Mitsuhara, I; Ohashi, Y; Seo, S; Yamakawa, H | 1 |
| Berra, E; Pouysségur, J; Richard, DE; Roux, D | 1 |
| Itoh, M; Matsumura, Y; Ohkita, M; Shibata, A; Takaoka, M | 1 |
| Fujii, Y; Fujimoto, K; Fujita, J; Fujita, T; Masunaga, Y; Mayumi, T; Mori, K; Nakagawa, S; Nakanishi, T; Okada, N; Saito, T; Tanaka, K; Yamamoto, A | 1 |
| Bal, V; Bhatia, S; Dani, A; George, A; Mayor, S; Mukherjee, P; Rath, S; Rudensky, AY; Singh, N | 1 |
| Morley, SJ; Pain, VM | 1 |
| de Jong, APJM; Herberts, CA; Melief, CJM; Poelen, MCM; Roholl, PJM; Stittelaar, KJ; van Alphen, LJW; van der Heeft, E; van Els, CACM; van Gaans-van den Brink, J | 1 |
| Almond, JB; Cain, K; Cohen, GM; Dinsdale, D; Hunter, A; Snowden, RT | 1 |
| Larsen, KE; Rideout, HJ; Stefanis, L; Sulzer, D | 1 |
| Ahlemeyer, B; Becker, A; Klumpp, S; Krieglstein, J; Ravati, A | 1 |
| Ikemoto, H; Kitagawa, H; Matsumoto, T; Tani, E | 1 |
| Dirnagl, U; Gieche, J; Grune, T; Harms, C; Ruscher, K; Schmitt, M; Weih, M | 1 |
| Fouchier, RA; Nieuwkoop, NJ; Osterhaus, AD; Rimmelzwaan, GF; Voeten, JT | 1 |
| Betz, H; Büttner, C; Griffon, N; Laube, B; Leyendecker, A; Sadtler, S; Schmalzing, G | 1 |
| Ashok, BT; Kim, E; Mittelman, A; Tiwari, RK | 1 |
| Altun, M; Fiebiger, E; Hekking, BG; Kessler, BM; Kisselev, AF; Overkleeft, HS; Ploegh, HL; Tortorella, D | 1 |
| Burrows, J; Hale, PD; Hidvegi, T; Perlmutter, DH; Schmidt, B; Teckman, JH | 1 |
| Grune, T; Ullrich, O | 1 |
| Green, MP; Hayes, CJ; Prodger, JC; Sherlock, AE | 1 |
| Pham, N; Rotin, D | 1 |
| Hara, T; Hatakeyama, S; Kamura, T; Nakayama, K; Oshikawa, K | 1 |
| Braun, U; Camacho, F; Diaz-Meco, MT; Duran, A; García, JF; Leitges, M; Martin, P; Moscat, J; Rennert, PD; Sanz, L | 1 |
| Buck, M; Chojkier, M; Hunter, T; Poli, V | 1 |
| Avila, J; Hen, R; Hernández, F; Lucas, JJ; Martín-Aparicio, E; Yamamoto, A | 1 |
| Kimura, G; Ohtsu, M; Okuda, A | 1 |
| Bubeck, A; Kloetzel, PM; Koszinowski, UH; Muranyi, W; Reusch, U; Ruppert, T; Wagner, M | 1 |
| Botion, LM; Brasier, AR; Green, A; Tian, B; Udupi, V | 1 |
| Dirden, JC; Fukuhara, C; Tosini, G | 1 |
| Gafni, M; Keren, O; Sarne, Y; Shapira, M | 1 |
| Chen, LY; Chou, JY; Hiraiwa, H; Marsh, J; Pan, CJ; Shieh, JJ; Terzioglu, M | 1 |
| Ageta, H; Fukazawa, Y; Inokuchi, K; Kato, A; Sugiyama, H | 1 |
| Albanese, C; D'Amico, M; Hawcroft, G; Hull, MA; Markham, AF; Pestell, RG | 1 |
| Kanaji, S; Kanaji, T; Kuroiwa, M; Mihara, K; Niho, Y; Okamura, T; Osaki, K; Sakaguchi, M | 1 |
| Hasselgren, PO; Hershko, DD; Hungness, ES; Luo, GJ; Pritts, TA; Robb, BW | 1 |
| Bens, M; Bianchi, M; Cluzeaud, F; Feraille, E; Hasler, U; Martin, PY; Mordasini, D; Rousselot, M; Vandewalle, A | 1 |
| Bond, JS; Hengst, JA; Kadowaki, T; Tsukuba, T | 1 |
| Burton, GR; Lyle, RE; May, JS; McGehee, RE; Prince, AM | 1 |
| Brown, AD; Chaurasia, SS; Haque, R; Iuvone, PM; Klein, DC; Ma, M; Weller, J; Zawilska, JB | 1 |
| Cross, AS; Farrance, IK; Hall, G; Hasday, JD; Rogers, TB; Singh, IS; Wright, G | 1 |
| Bower, J; Castranova, V; Chen, F; Ding, M; Leonard, SS; Lu, Y; Piwnica-Worms, H; Shi, X; Zhang, Z | 1 |
| Bangham, CRM; Gould, KG; Hanon, E; Lomas, M; Tanaka, Y | 1 |
| Andreatta, C; Nahreini, P; Prasad, KN | 1 |
| Blystad, FD; Johannessen, LE; Larsen, AM; Longva, KE; Madshus, IH; Stang, E | 1 |
| Andriola, IF; Bailey, CK; Kampinga, HH; Merry, DE | 1 |
| Haggie, PM; Stanton, BA; Verkman, AS | 1 |
| Hui, EK; Nayak, DP | 1 |
| Engström, A; Larsson, M; Rask, L; Sakwe, AM | 1 |
| Bullock, TN; Eisenlohr, LC; Golovina, TN; Wherry, EJ | 1 |
| Bernstein, A; Donoviel, D; Honjo, T; Karlström, H; Lendahl, U; Lundkvist, J; Mizutani, T; Otaka, A; Taniguchi, Y; Vestling, M | 1 |
| Fischer, JE; Hasselgren, PO; Hershko, DD; Hungness, ES; Luo, GJ; Pritts, TA; Robb, BW; Sun, X; Wong, HR | 1 |
| Reboud-Ravaux, M | 1 |
| Asp, L; Borén, J; Claesson, C; Gustafsson, M; Li, L; Lindberg, K; Lindén, D; Olofsson, SO; Oscarsson, J | 1 |
| Li, QQ; Mimnaugh, EG; Neckers, L; Reed, E; Yu, JJ; Yunmbam, MK; Zhong, X | 1 |
| Ashworth, A; Theodosiou, A | 1 |
| Halliwell, B; Hattori, N; Hyun, DH; Jenner, P; Kubo, S; Lee, M; Mizuno, Y | 1 |
| Bao, W; Onischenko, A; Strömblad, S; Thullberg, M; Zhang, H | 1 |
| Jennert, P; Jnobaptiste, R; McNaught, KS; Mytilineou, C; Olanow, CW; Shashidharan, P; Yabut, J | 1 |
| Cavaleyra, M; Daulouede, S; Holzmuller, P; Lemesre, JL; Mangot, I; Sereno, D; Vincendeau, P | 1 |
| Bogyo, M; Wang, EW | 1 |
| Aktories, K; Fritz, G; Lerm, M; Pop, M; Schmidt, G | 1 |
| Kikuchi, S; Niino, M; Shinpo, K; Takeuchi, M; Tashiro, K; Tsuji, S; Yabe, I | 1 |
| Notterpek, L; Ryan, MC; Shooter, EM | 1 |
| Bofinger, D; Chen, CY; Koury, ST; Pajak, L; Tamburlin, J | 1 |
| Schenkein, D | 1 |
| Lin, WW; Wen, HC; Wu, HM | 1 |
| Lehmensiek, V; Schwarz, J; Storch, A; Tan, EM | 1 |
| Belizaire, R; Björklund, LM; Isacson, O; Jenner, P; McNaught, KS; Olanow, CW | 1 |
| Boone, AN; Vijayan, MM | 1 |
| Ali-Osman, F; Srivenugopal, KS | 1 |
| Kramer, D; Rondinone, CM | 1 |
| Chi, KH; Lin, WW; Wu, HM | 1 |
| Melmed, S; Ren, SG; Yu, R | 1 |
| Arscott, PL; Baker, JR; Bretz, JD; Gauger, PG; Mezosi, E; Thompson, NW; Utsugi, S; Wang, SH; Yamazaki, H | 1 |
| Emi, Y; Ikushiro, S; Iyanagi, T; Omura, S | 1 |
| Barrett, PH; Borradaile, NM; de Dreu, LE; Huff, MW | 1 |
| David, DC; Goedert, M; Layfield, R; Narain, Y; Serpell, L; Spillantini, MG | 1 |
| Bachi, A; Burri, L; Hellman, U; Lévy, F; Lévy, N; Morel, S; Peitrequin, AL; Servis, C; Van den Eynde, BJ | 1 |
| Bescos, PB; Davies, KJ; Grune, T; Li, R; North, JA; Reinheckel, T; Shringarpure, R | 1 |
| Lindquist, S; Ma, J | 1 |
| Duckles, SP; Krause, DN; Stirone, C | 1 |
| Chen, M; Hemmerich, P; Risch, J; Rockel, T; Steinweger, G; von Mikecz, A | 1 |
| Benjamin, IJ; Christians, E; Connell, P; Forster, M; McMillan, DR; Morgan, S; Plumier, JC; Richardson, J; Xiao, X; Zuo, X | 1 |
| Kerokoski, P; Pirttilä, T; Salminen, A; Soininen, H; Suuronen, T | 1 |
| Barret, A; Corvol, P; Etienne, E; Meidan, R; Muller, L; Tougard, C; Valdenaire, O | 1 |
| Dai, W; Darzynkiewicz, Z; Jhanwar-Uniyal, M; Liu, T; Luo, L; Ruan, Q; Traganos, F; Wang, Q; Xie, S | 1 |
| Bessho, Y; Harada, T; Hirata, H; Kageyama, R; Ohtsuka, T; Yoshikawa, K; Yoshiura, S | 1 |
| Backlund, PS; Bourdon, E; Drake, SK; Levine, RL; Rouault, TA; Wehr, NB; Yergey, AL | 1 |
| Chaudhary, PM; Matta, H; Sun, Q | 1 |
| Baek, SJ; Jeong, MH; Jeong, SJ; Kim, KH; Lee, SW; Park, BS; Seo, SY; Song, KH; Yoo, KS; Yoo, YH | 1 |
| Junn, E; Kim, YM; Lee, G; Mouradian, MM; Tanaka, M | 1 |
| Dash, BC; Dicker, DT; El-Deiry, WS; Hong, R; Sax, JK | 1 |
| Hattori, M; Miki, H; Mikoshiba, K; Suetsugu, S; Takenawa, T; Tezuka, T; Yamamoto, T | 1 |
| Bückig, A; Herzog, V; Schmitz, A; Tikkanen, R | 1 |
| Chen, LY; Chou, JY; Pan, CJ; Shieh, JJ | 1 |
| Kisliakova, TV; Malashicheva, AB; Pospelov, VA; Savatier, P | 1 |
| Blat, Y; Bradley, JD; Meredith, JE; Olson, RE; Seiffert, D; Stern, AM; Thompson, LA; Wang, Q | 1 |
| Davis, AE; Liu, D; Prada, AE; Scafidi, J; Zahedi, K | 1 |
| Jenner, P; McNaught, KS; Olanow, CW; Perl, DP; Shashidharan, P | 1 |
| Ahmed, R; Ansari, AA; Bostik, P; Jensen, PE; Mayne, AE; Mori, K; Villinger, F | 1 |
| Adachi, H; Doyu, M; Du, J; Katsumo, M; Kobayashi, Y; Sang, C; Sobue, G | 1 |
| Franzen, R; Huwiler, A; Pfeilschifter, J | 1 |
| Aggarwal, BB; Banerjee, S; Liu, M; Mukhopadhyay, A; Stafford, LJ; Xia, C | 1 |
| Kashiwagi, A; Kishi, A; Maegawa, H; Nakamura, T; Nishio, Y | 1 |
| Golding, H; King, LR; Lapham, CK; Manischewitz, J; Petricoin, E; Romantseva, T; Zaitseva, MB | 1 |
| Hosoyama, Y; Miyata, S; Sekiguchi, T | 1 |
| Avraham, HK; Miralem, T | 1 |
| Aravamudan, B; Broadie, K | 1 |
| Faivre, E; Horwitz, KB; Lange, CA; Olsen, A; Qiu, M | 1 |
| Allin, SM; Andrews, DM; Bulman Page, PC; Hamzah, AS; Leach, DC; Rassias, GA | 1 |
| De Ridder, M; Monsaert, C; Storme, GA; Van den Berge, DL; Verovski, VN; Wauters, N | 1 |
| Caplan, AJ; Cardozo, CP; Fliss, AE; Hall, SJ; Michaud, C; Ost, MC; Patterson, C; Yang, E | 1 |
| Beckermann, B; Deres, K; Goldmann, S; Graef, E; Gross, R; Hacker, HJ; Haebich, D; Jaeger, R; Koletzki, D; Krämer, T; Masantschek, RN; Niewöhner, U; Paessens, A; Pleiss, U; Reimann, A; Rübsamen-Waigmann, H; Schlemmer, KH; Schröder, CH; Stoltefuss, J; Weber, O | 1 |
| Park, DS; Rideout, HJ; Stefanis, L; Wang, Q | 1 |
| Day, BN; McCauley, TC; Sutovsky, M; Sutovsky, P | 1 |
| Ahn, HB; Bae, HR; Kim, JM; Lee, JM; Park, BS; Park, WC; Rho, JH; Rho, SH; Yoo, KW; Yoo, YH; Yoon, HS | 1 |
| Denmat-Ouisse, LA; Faye, L; Gomord, V; Pagny, S | 1 |
| Hosokawa, N; Nagata, K; Oda, Y; Wada, I | 1 |
| Rothstein, TL; Schram, BR | 1 |
| Halban, PA; Irminger, JC | 1 |
| Jun, EJ; Jung, SM; Kim, JK; Kim, KH; Kim, ND; Lee, S; Lim, YJ; Park, BS; Seo, SY; Suh, H; Yoo, YH | 1 |
| Bogner, C; Decker, T; Hipp, S; Peschel, C; Ringshausen, I; Schneller, F | 1 |
| Imai, K; Kunimatsu, M; Liu, ZQ; Manabe, T; Okamoto, T; Sasaki, M; Takeyama, H; Teranishi, F | 1 |
| Dean, RT; Rodgers, KJ | 1 |
| Besio Moreno, M; Lopez Salon, M; Pasquini, JM; Pasquini, L; Soto, E | 1 |
| Carter, S; Clague, MJ; Hammond, DE; McCullough, J; Urbé, S; Vande Woude, G | 1 |
| Dryden, SC; Goustin, AS; Nahhas, FA; Nowak, JE; Tainsky, MA | 1 |
| Brody, JP; Harris, JW; Lin, F; Thompson, HG; Wold, BJ | 1 |
| Sunazuka, T | 1 |
| Dietrich, W; Huber, JC; Kolbus, A; Stonek, F; Tschugguel, W; Zhegu, Z | 1 |
| Davies, KJ; Demasi, M | 1 |
| Herscovics, A; Hosokawa, N; Nagata, K; Tremblay, LO; Wada, I; You, Z | 1 |
| Doong, H; Fang, S; Kohn, EC; Kulpa, V; Rizzo, K; Weissman, AM | 1 |
| Silver, DL; Vogel, S; Wang, N | 1 |
| Berger, K; Cookson, MR; Eberhardt, O; Engelender, S; Farrer, MJ; Gerhardt, E; Hernandez, D; Holzmann, C; Kachergus, J; Krüger, R; Li, L; Marx, FP; Riess, O; Ross, CA; Schöls, L; Schulz, JB; Strauss, KM | 1 |
| Choi, HJ; Huh, GY; Jeong, JH; Kim, HH; Kim, JM; Lee, HS; Seo, SY; Yoo, YH | 1 |
| Alaoui-Jamali, MA; Igdoura, SA; Laird, DW; Qin, H; Shao, Q | 1 |
| Bharadwaj, LA; Davies, GF; Ovsenek, N; Roesler, WJ | 1 |
| Bagutti, C; Chiquet-Ehrismann, R; Ferralli, J; Forro, G; Rubin, B | 1 |
| Dagia, NM; Goetz, DJ | 1 |
| Moreno, MA; Paez, PM; Pasquini, JM; Pasquini, LA; Soto, EF | 1 |
| Moremen, KW; Sifers, RN; Swulius, MT; Wu, Y | 1 |
| Luker, GD; Luker, KE; Pica, CM; Piwnica-Worms, D; Song, J | 1 |
| Bland, FA; Braud, VM; Lemberg, MK; Martoglio, B; McMichael, AJ | 1 |
| Akimitsu, N; Hossain, MS; Kurokawa, K; Sekimizu, K | 1 |
| Bogner, C; Decker, T; Fend, F; Goetze, K; Häcker, G; Oostendorp, R; Peschel, C; Quintanilla-Martinez, L; Ringshausen, I; Schneller, F | 1 |
| Ostrowska, H; Ostrowska, JK; Radziwon, P; Worowski, K | 1 |
| Bhattacharya, S; Calbó, J; Garriga, J; Graña, X; Haines, DS; Marshall, RM; Truongcao, M | 1 |
| Calvaruso, G; D'Anneo, A; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R | 1 |
| Chen, L; Smith, JB; Smith, L; Wang, Z | 1 |
| Halliwell, B; Hyun, DH; Jenner, P; Lee, M | 2 |
| Lenschat, A; Morrison, DC; Perera, PY; Qureshi, N; Shen, J; Splitter, G; Vogel, SN; Zhang, G | 1 |
| Cemerski, S; Romagnoli, P; van Meerwijk, JP | 1 |
| He, K; Hu, MR; Jin, BF; Lan, Y; Shen, BF; Wang, HX; Wang, J; Wei, KH; Yang, SC; Zhang, XM; Zhou, T | 1 |
| Biocca, S; Cardinale, A; Filesi, I; Mattei, S | 1 |
| Feng, J; Jiang, Q; Ren, Y; Zhao, J | 1 |
| Ansari, AA; Coppel, RL; Gershwin, ME; He, XS; Imawari, M; Inamori, H; Isoda, N; Kaplan, M; Kita, H; Lian, ZX; Luketic, V; Sugano, K; Van de Water, J | 1 |
| Abu-Baker, A; Brais, B; Gaspar, C; Laganiere, J; Messaed, C; Rouleau, GA | 1 |
| Caltagirone, A; Chahine, D; Fillebeen, C; Pantopoulos, K; Segal, P | 1 |
| Bauer, TM; Daniel, V; Naujokat, C; Opelz, G; Sadeghi, M | 1 |
| Alessandri, MG; Busceti, CL; Ferrucci, M; Fornai, F; Gesi, M; Lazzeri, G; Lenzi, P; Paparelli, A; Ruffoli, R; Ruggieri, S; Soldani, P | 1 |
| Kawamura, Y; Kokame, K; Komano, H; Miyata, T; Sai, X; Shiraishi, H; Yanagisawa, K | 1 |
| Li, QL; Lin, HY; Liu, DL; Liu, GY; Qian, D; Wang, HM; Yu, XD; Zhang, X; Zhu, C | 1 |
| Aki, T; Mizukami, Y; Yoshida, K | 1 |
| Barve, SS; Butt, W; Joshi-Barve, S; Klein, J; McClain, CJ | 1 |
| Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H | 1 |
| Bridge, E; Corbin-Lickfett, KA | 1 |
| Harris, RC; Singh, AB | 1 |
| Delvin, E; Lambert, M; Levy, E; Seidman, E; Ziv, E; Zoltowska, M | 1 |
| Khor, R; McElroy, LJ; Whittaker, GR | 1 |
| Bear, MF; Colledge, M; Crozier, RA; Jin, Y; Langeberg, LK; Lu, H; Scott, JD; Snyder, EM; Soderling, JA | 1 |
| Coleman, MP; Laser, H; Mack, TG; Wagner, D | 1 |
| Akaike, A; Ibi, M; Inden, M; Izumi, Y; Kihara, T; Kitamura, Y; Kohno, R; Nakamizo, T; Nakanishi, M; Sakka, N; Sawada, H; Shibasaki, H; Shimohama, S; Taniguchi, T; Yamakawa, K; Yamamoto, N | 1 |
| Awasthi, N; Wagner, BJ | 1 |
| Husbyn, M; Kavlie, A; Prydz, H; Stormorken, H; Wiiger, MT | 1 |
| Akinaga, S; Asai, A; Funakoshi, M; Kobayashi, H; Mizukami, T; Sharma, SV; Tsujita, T; Yamashita, Y | 1 |
| Hanson, AJ; Kumar, B; Prasad, KN | 1 |
| Bradbury, NA; Devor, DC; Hamilton, KL; Jones, HM; Papworth, GD; Syme, CA; Watkins, SC | 1 |
| Song, PH; Wu, J; Xie, HY; Zheng, SS | 1 |
| Bisceglio, G; Farrer, MJ; Hulihan, M; Kachergus, J; Lincoln, S; Lockhart, PJ; Mash, DC; Wilkes, K | 1 |
| Evdonin, AL; Medvedeva, ND; Nikol'skiĭ, NN; Tsupkina, NV | 1 |
| Bu, G; Li, Y; Lu, W; Schwartz, AL | 1 |
| Cullen, DA; Gallo, JM; Leigh, PN | 1 |
| Hughson, FM; Krieger, M; Oka, T; Ungar, D | 1 |
| Akhouayri, O; Prud'homme, J; Quélo, I; St-Arnaud, R | 1 |
| Andersen, CI; Bennett, RG; Berhanu, P; Duckworth, WC; Fawcett, J; Hamel, FG | 1 |
| Han, ST; Jin, IN; Kim, OH; Kim, YH; Kwon, TK; Lim, JH; Park, JW; Woo, KJ | 1 |
| Cheema, SS; Lopes, EC; Turner, BJ | 1 |
| Chou, JY; Mansfield, BC; Pan, CJ; Shieh, JJ | 1 |
| Chen, L; Jondal, M | 1 |
| Gairin, JE; Girbal-Neuhauser, E; Monsarrat, B; Xu, B | 1 |
| Fujii, H; Kono, K; Mimura, K; Naganuma, H; Nukui, H; Sato, E; Takahashi, A | 1 |
| Donohoe, TJ; Harling, JD; Sintim, HO; Sisangia, L | 1 |
| Johnson, CS; Singh, SV; Trump, DL; Xiao, D | 1 |
| Chang, YC; Kwon, TK; Lim, JH; Park, JW; Park, YB | 1 |
| Basta, S; Bennink, JR; Berglund, P; Donohue, KB; Gibbs, J; Norbury, CC; Princiotta, MF; Tscharke, DC; Yewdell, JW | 1 |
| Chang, T; Hayes, EC; Mitra, SW; Peekhaus, NT; Rohrer, SP; Schaeffer, JM; Wilkinson, HA | 1 |
| Jaarsma, D; Vlug, AS | 1 |
| Goldbaum, O; Richter-Landsberg, C | 1 |
| Eyfjord, JE; Mikaelsdottir, EK; Rafnar, T; Valgeirsdottir, S | 1 |
| Horta, MF; Ramalho-Pinto, FJ; Silva-Jardim, I | 1 |
| Hodges, H; Lendahl, U; Mellodew, K; Price, J; Reuter, I; Suhr, R; Uwanogho, DA | 1 |
| Caamaño, JN; Day, BN; Manandhar, G; McCauley, TC; Sutovsky, M; Sutovsky, P; Thompson, WE | 1 |
| Andersson, T; Ares, MP; Grethe, S; Pörn-Ares, MI | 1 |
| Christensen, MA; Qing, H; Song, W; Sun, X; Tong, Y; Zhou, W | 1 |
| Bay, BH; Beart, PM; Cheng, HC; Cheung, NS; Chiu, LL; Choy, MS; Halliwell, B; Koay, ES; Koh, VH; Lee, AY; Qi, RZ; Teo, TS; Whiteman, M; Wong, KP; Zhu, HJ | 1 |
| Dauer, WT; Dietrich, P; Rideout, HJ; Stefanis, L; Wang, Q | 1 |
| Fishman, PH; Liang, W | 1 |
| Lang-Rollin, I; Rideout, HJ; Stefanis, L; Vekrellis, K; Wang, Q | 1 |
| Bakke, M; Børud, B; Cook, C; Fenne, IS; Hoang, T; Lien, EA; Mellgren, G | 1 |
| Conn, KJ; Eisenhauer, PB; Fine, RE; Gao, W; Lan, MS; McKee, A; Ullman, MD; Wells, JM | 1 |
| Hitomi, Y; Izawa, T; Kizaki, T; Ogasawara, J; Ohno, H; Rahman, N; Sakurai, T | 1 |
| Huang, J; Hupfeld, CJ; Imamura, T; Lefkowitz, RJ; Olefsky, JM; Satoh, H; Shenoy, SK; Usui, I | 1 |
| Ando, K; Hayakawa, M; Kikugawa, K; Kiuchi, Y; Shimizu, K | 1 |
| Dunbar, AY; Jenkins, GJ; Lau, M; Morishima, Y; Osawa, Y; Patterson, C; Peng, HM; Pratt, WB | 1 |
| Carter, S; Clague, MJ; Urbé, S | 1 |
| Cowburn, RF; Flood, F; Johnston, JA; Lannfelt, L; Murphy, S; Walker, B | 1 |
| Baptiste, RJ; McNaught, KS; Mytilineou, C; Olanow, CW; Parnandi, A; Shashidharan, P; Yabut, J | 1 |
| Kobayashi, M; Maeshima, Y; Makino, H; Onoda, T; Sugiyama, H; Sunami, R; Tsukinoki, T; Yamasaki, Y | 1 |
| Christianson, JC; Green, WN | 1 |
| Henfling, ME; Ramaekers, FC; Schutte, B | 1 |
| Hatakeyama, S; Ishibashi, N; Ishihara, J; Iwabuchi, Y; Ooi, H | 1 |
| Chang, EB; De Simone, C; Kojima, K; Musch, MW; Petrof, EO; Ropeleski, MJ; Tao, Y | 1 |
| Kimura, T; Koyama, M; Koyama, S; Murata, Y; Nakamura, H; Ogita, K; Shimoya, K; Tomiie, M; Tsutsui, T; Yoshida, S | 1 |
| Tang, FL; Yu, MX; Zeng, XF; Zhang, FC; Zhang, W; Zhang, X | 1 |
| Higgins, D; Horbinski, C; Kim, WY; Sigurdson, W | 1 |
| D'Alessio, A; De Cesaris, P; Filippini, A; Galli, R; Giampietri, C; Petrungaro, S; Riccioli, A; Starace, D; Ziparo, E | 1 |
| Ballestrero, A; Barbieri, E; Belka, C; Brossart, P; Cardone, MH; Dillon, CP; Garuti, A; Hua, F; Nencioni, A; Patrone, F; Rocco, I; Scheiermann, C; Wesselborg, S; Yokoo, R | 1 |
| Allaman-Pillet, N; Billestrup, N; Bonny, C; Karlsen, AE; Mandrup-Poulsen, T; Størling, J | 1 |
| Feng, S; Kroll, MH; Lu, X | 1 |
| Carreras, I; Conn, KJ; Eisenhauer, PB; Fine, RE; Garrett-Young, R; Ullman, MD; Wells, JM | 1 |
| Adamo, AM; De Moliner, KL; Perrone Bizzozero, N; Wolfson, ML | 1 |
| Qing, H; Song, W; Tong, Y; Zhou, W | 1 |
| Gaskins, HR; Kitiphongspattana, K; Leiter, EH; Mathews, CE | 1 |
| Kutty, BC; Mishra, KP; Pasupathy, K | 1 |
| Bouvard, D; Didelot, N; Guenou, H; Kaabeche, K; Listrat, A; Marie, PJ | 1 |
| Baumann, G; Black, RA; Cowan, JW; Frank, SJ; Guan, R; He, K; Jiang, J; Wang, X; Wolfe, MS | 1 |
| Gong, Q; Keeney, DR; Molinari, M; Zhou, Z | 1 |
| Kabuta, T; Setsuie, R; Wada, K | 1 |
| Ahmad, R; Blackinton, J; Canet-Avilés, RM; Cookson, MR; Hague, SM; Kaleem, M; Miller, DW; van der Brug, MP | 1 |
| Itoh, K; Kobayashi, A; Kumagai, T; Kusano, Y; Osada, S; Uchida, K; Usami, H; Yamamoto, M | 1 |
| Ahn, MT; Kalbe, L; Kruhoffer, M; Leunda, A; Meulemans, C; Nerup, J; Orntoft, T; Remacle, C; Reusens, B; Sparre, T | 1 |
| Morrison, DC; Papasian, CJ; Qureshi, AA; Qureshi, N; Van Way, C; Vogel, SN | 1 |
| Dong, Y; Liu, B; Mei, ZZ; Song, Y; Sun, GJ; Sun, ZX; Zheng, XF | 1 |
| Aatsinki, JT; Apaja, PM; Hakalahti, AE; Petäjä-Repo, UE; Pietilä, EM; Rajaniemi, HJ; Tuusa, JT | 1 |
| Berhane, B; Chernushevich, IV; Kaddis, CS; Kaufman, SL; Loo, JA; Wooding, KM; Xie, Y | 1 |
| Holland, RC; Ness, GC | 1 |
| Lang-Rollin, IC; Rideout, HJ; Savalle, M; Stefanis, L | 1 |
| Le, W; Pan, T; Qu, S; Wang, X; Xie, W; Zhang, X | 1 |
| Kawatani, Y; Minegishi, N; Shimizu, R; Suzuki, N; Yamamoto, M | 1 |
| Cheung, NS; Chiu, LL; Choy, MS; Halliwell, B; Kandiah, J; Koay, ES; Lee, AY; Manikandan, J; Melendez, AJ; Ng, WL; Peng, ZF; Qi, RZ; Whiteman, M; Yew, EH | 1 |
| Gallimore, PH; Grand, RJ; Hussain, R; Mymryk, JS; Turnell, AS; Zhang, X | 1 |
| Bockmühl, U; Fuchs, J; Gross, J; Jahnke, V; Kietzmann, T; Machulik, A | 1 |
| Peng, A; Tan, X; Tang, Z; Wang, Y | 1 |
| Barnes, S; Grizzle, WE; Kimberly, RP; Koopman, WJ; Liu, C; Mountz, JD; Wang, J; Yang, X; Yu, S; Zhang, HG; Zhang, S | 1 |
| Jabado, O; Lang-Rollin, I; Maniati, M; Papantonis, S; Rideout, HJ; Stefanis, L; Vekrellis, K | 1 |
| Brandner, S; Collinge, J; Klöhn, PC; Kristiansen, M; Messenger, MJ; Tabrizi, SJ; Wadsworth, JD | 1 |
| Hiramatsu, A; Kiyotani, K; Kuwayama, M; Sakaguchi, T; Shimazu, Y; Sugahara, F; Tanaka, Y; Watanabe, H; Yoshida, T | 1 |
| Block, T; Dwek, RA; Mehta, A; Simsek, E; Zhou, T | 1 |
| Michael Iuvone, P; Rosiak, J; Zawilska, JB | 1 |
| Bowen, EG; Wardrop, DJ | 1 |
| Kikuchi, S; Kishimoto, R; Sasaki, H; Shinpo, K; Takeuchi, M; Tashiro, J; Tsuji, S; Yabe, I; Yamagishi, S | 1 |
| Daniel, KG; Dou, QP; Kazi, A; Kuhn, DJ | 1 |
| Chen, SD; Li, B; Liang, L; Lu, GQ; Xu, JY; Yang, H | 1 |
| Hollenberg, PF; Lin, HL; Morishima, Y; Osawa, Y; Peng, HM; Pratt, WB; Sunahara, RK | 1 |
| Boncoeur, E; Bonvin, E; Clement, A; Fritah, A; Henrion-Caude, A; Jacquot, J; Lefait, E; Muselet, C; Redeuilh, G; Tabary, O | 1 |
| Divald, A; Powell, SR | 1 |
| Grandal, M; Hommelgaard, AM; Lerdrup, M; van Deurs, B | 1 |
| Kaddour-Djebbar, I; Kumar, MV; Lakshmikanthan, V; Lewis, RW; Patel, DM; Shirley, RB | 1 |
| Basile, DP; Gama, V; Gomez, JA; Haas, AL; Matsuyama, S; Mayo, LD; Yoshida, T | 1 |
| Cho, HR; Choi, DH; Chung, DK; Kim, JS; Kim, SB; Ko, MS; Kwon, BS; Lee, BJ; Lee, DS; Lee, HW; Lee, JH; Park, JW; Yoon, WJ | 1 |
| Chizzolini, C; Dayer, JM; Fineschi, S; Guerne, PA; Reith, W | 1 |
| Clark, AF; Yorio, T; Zhang, X | 1 |
| Fukuda, N; Kanai, M; Sasaki, K; Sastry, TV; Shibasaki, M | 1 |
| Bole-Feysot, C; Coëffier, M; Déchelotte, P; Ducrotté, P; Hubert-Buron, A; Leblond, J | 1 |
| Apaja, PM; Petäjä-Repo, UE; Pietilä, EM; Rajaniemi, HJ; Tuusa, JT | 1 |
| Alao, JP; Coombes, RC; Lam, EW; Stavropoulou, AV; Vigushin, DM | 1 |
| Andreu, EJ; Armengod, ME; Chaves, FJ; Fuertes, G; Knecht, E; Martín de Llano, JJ; Puig, O; Soutar, AK | 1 |
| Hausott, B; Ingorokva, S; Klimaschewski, L; Pfaller, K | 1 |
| Cosse, JP; Demazy, C; Michiels, C; Minet, E; Raes, M | 1 |
| Kalejta, RF; Saffert, RT | 1 |
| Brem, H; DiMeco, F; Fiorindi, A; Gaini, SM; Legnani, FG; Olivi, A; Pradilla, G; Recinos, PF; Thai, QA; Tyler, BM | 1 |
| Bosari, S; Carelli, S; Di Giulio, AM; Gorio, A; Paratore, S | 1 |
| Griffiths, HR; Luan, Y | 1 |
| Ahn, TB; Jeon, BS | 1 |
| Liao, XM; Qu, ZS; Ren, QG; Wang, JZ; Wang, ZF | 1 |
| Hosler, MR; Wagner, BJ; Wang-Su, ST | 1 |
| Kolbert, C; Morrison, DC; Papasian, C; Qureshi, AA; Qureshi, N; Raghavakaimal, S; Reis, J; Shen, J; Vogel, SN | 1 |
| Kulms, D; Pöppelmann, B; Schwarz, T; Strozyk, E | 1 |
| Balskus, EP; Jacobsen, EN | 1 |
| Gao, JJ; Morrison, DC; Papasian, C; Qureshi, N; Shen, J; Tan, X; Vogel, SN; Zhang, G | 1 |
| Couillaud-Battaglia, S; Fortun, Y; Heymann, D; Padrines, M; Redini, F; Tat, SK; Theoleyre, S | 1 |
| Bauer, NN; Erickson, PF; Fankell, D; Garat, CV; Klemm, DJ; McMurtry, IF; Reusch, JE | 1 |
| Konishi, Y; Tominaga, A | 1 |
| Bay, BH; Cheng, HC; Cheung, NS; Choy, MS | 1 |
| Lim, HS; Lu, XY; Paz, J; Yao, H; Zhang, W | 1 |
| Kobayashi, H; Maruta, T; Nemoto, T; Satoh, S; Sugano, T; Wada, A; Yanagita, T; Yokoo, H; Yoshikawa, N | 1 |
| Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W | 1 |
| Boggaram, V; Das, A | 1 |
| Di Monte, DA; Johnston, LC; Langston, WJ; Reaney, SH | 1 |
| Courtoy, PJ; de Diesbach, P; Feyt, C; Huysseune, S; Kienlen-Campard, P; N'Kuli, F; Octave, JN | 1 |
| Chen, JG; He, Q; Huang, HY; Jiang, L; Li, X; Liu, DG; Liu, HL; Ma, CG; Ma, D; Song, HY; Song, TJ; Tang, QQ | 1 |
| Fujii, N; Hamamoto, T; Kagawa, Y; Kinouchi, T; Nishio, H; Nishiuchi, Y; Takada, K; Tsunemi, M | 1 |
| Bourlier, V; De Barros, S; Galitzky, J; Lafontan, M; Zakaroff-Girard, A | 1 |
| Humphreys, I; Loganathan, S; Srivastava, SK; Zhang, R | 1 |
| Bernstein, A; Cai, F; He, G; Kwok, C; Qing, H; Song, W; Xu, H; Yu, G | 1 |
| Berges, C; Daniel, V; Fuchs, D; Höh, A; Miltz, M; Naujokat, C; Opelz, G; Ovens, J; Sadeghi, M; Wieczorek, H | 1 |
| Jacobs, JM; Nichols, RC; Noreault-Conti, TL; Sinclair, JF; Trask, HW; Wrighton, SA | 1 |
| Aguilar, F; Antón, LC; Del Val, M; Guil, S; Rodríguez-Castro, M; Villasevil, EM | 1 |
| Li, ZH; Ma, X; Meng, H; Shu, Z; Zhang, BX; Zhang, W | 1 |
| Al-Hendy, A; Garfield, RE; Jamaluddin, M; Wentz, MJ | 1 |
| Anselmino, A; Atzori, C; Cargnel, A; Mazza, F; Piccinini, M; Rinaudo, MT; Tronconi, E; Valerio, A | 1 |
| Inomata, M; Nakamura, M; Ohno, H; Shintani-Ishida, K; Uemura, K; Yoshida, K | 1 |
| Rockel, TD; Scharf, A; von Mikecz, A | 1 |
| Biederbick, A; Chen, G; Fillebeen, C; Lill, R; Pantopoulos, K; Wang, J | 1 |
| Bacon, KB; Benet-Buchholz, J; Bitzer, J; Gantner, F; Mayer-Bartschmid, A; Müller, H; Reinemer, P; Stadler, M; Tichy, HV | 1 |
| Rosen, JM; Schwertfeger, KL; Xian, W | 1 |
| Courtois, G; Falvo, JV; Goldfeld, AE; Schmidt-Supprian, M; Thanos, D; Tsytsykova, AV | 1 |
| Cai, F; He, G; Ishiura, S; Qing, H; Song, W; Tong, Y | 1 |
| Dubey, D; Ganesh, S; Mittal, S; Yamakawa, K | 1 |
| Chen, XQ; Liao, XM; Liu, GP; Ren, QG; Wang, JZ | 1 |
| Fadeel, B; Ottosson, A; Pervaiz, S; Sun, Y | 1 |
| Bredesen, DE; Egger, L; Madden, DT; Rao, RV; Rhême, C | 1 |
| Fukuda, N; Kanai, M; Shibasaki, M | 1 |
| Bottoni, A; Luchin, A; Piccin, D; Tagliati, F; Uberti, EC; Vignali, C; Zatelli, MC | 1 |
| Pollenz, RS | 1 |
| Deng, L; Frank, SJ; Fuchs, SY; He, K; Jiang, J; Thangavel, C; Wang, X; Yang, N | 1 |
| Bulbarelli, A; Cassetti, A; Cazzaniga, E; Lonati, E; Masserini, M; Mutoh, T; Palestini, P; Re, F | 1 |
| Chellas-Géry, B; Fields, KA; Linton, CN | 1 |
| Furuya, H; Harayama, Y; Imanaka, T; Kashiwayama, Y; Maeda, T; Morita, M; Sato, R; Shimozawa, N; Suzuki, Y; Takahashi, N | 1 |
| Chen, S; Le, W; Li, L; Li, X; Peng, C; Yang, D | 1 |
| Chen, Y; Jiang, YP; Su, YR; Wang, J; Wu, JJ | 1 |
| Hainaut, P; Hautefeuille, A; Mion, F; Pétré, A; Roman, S; Scoazec, JY; Thépot, A | 1 |
| Fukui, K; Kawataki, T; Koike, T; Yang, Y | 1 |
| Armentero, MT; Bazzini, E; Blandini, F; Granelli, M; Levandis, G; Nappi, G; Samuele, A | 1 |
| Lingwood, CA; Tam, PJ | 1 |
| Jiang, T; Liu, J; Shi, L; Wang, J; Wei, L | 1 |
| Fridkin, M; Jankovic, J; Le, W; Pan, T; Xie, W; Xu, P; Youdim, MB; Zheng, H; Zhu, W | 1 |
| Chiou, SK; Mandayam, S | 1 |
| Li, YH; Liu, KX; Tian, XF; Wang, YZ; Wang, ZZ; Yao, JH; Yuan, JC; Zhang, XS; Zhou, Q | 1 |
| Kankaanranta, H; Leppänen, T; Moilanen, E; Paukkeri, EL; Sareila, O; Vuolteenaho, K | 1 |
| Le, W; Li, L; Li, X; Ming, M; Peng, C; Yang, D | 1 |
| Arakawa, H; Bortolin-Cavaillé, ML; Buerstedde, JM; Cavaillé, J; Hainaut, P; Kinomura, A; Messaoudi, L; Stavreva, DA; Takata, M; Van Dyck, E; Yan, G; Yang, YG | 1 |
| Aburatani, H; Fukayama, M; Goto, A; Ishikawa, S; Matsubara, D; Miyazawa, K; Nakamura, Y; Niki, T; Ota, S; Sachiko, O | 1 |
| Carlsson, T; Karlsson, JO; Petersen, A; Zetterberg, M | 1 |
| Cerretti, DP; Fasen, K; Huynh-Do, U | 1 |
| Chen, SD; Li, B; Niu, GZ; Yang, H; Zhou, HY | 1 |
| Das, DK; Goswami, S; Gurusamy, N; Malik, G | 1 |
| Gerelchuluun, T; Han, K; Im, SA; Kim, K; Lee, CK; Lee, YH; Lee, YR; Park, JS; Song, S | 1 |
| Callegari, F; Rossini, GP | 1 |
| Alden, CL; Csizmadia, E; Csizmadia, V; Fedyk, ER; Raczynski, A; Rottman, J | 1 |
| Blau, IW; Busse, A; Driessen, C; Keilholz, U; Kraus, M; Na, IK; Rietz, A; Scheibenbogen, C; Thiel, E | 1 |
| Hirose, T; Omura, S; Sunazuka, T | 1 |
| Berges, C; Daniel, V; Fuchs, D; Haberstock, H; Miltz, M; Naujokat, C; Opelz, G; Sadeghi, M | 1 |
| Blake, AJ; Green, MP; Hayes, CJ; Prodger, JC; Selby, MD; Sherlock, AE; Wilson, C | 1 |
| Ishimi, Y; Takezawa, J; Yamada, K | 1 |
| Hahn, JS; Kim, HY; Kim, M; Lee, IH; Paik, SR | 1 |
| Gorospe, M; Kawai, T; Otto, K; Rinker-Schaeffer, CW; Robinson, VL; Shalhav, O | 1 |
| Long, X; Schafer, AI | 1 |
| Ahn, TB; Jeon, BS; Kwon, SJ; Yoon, MY | 1 |
| Campos, EI; Garate, M; Li, G; Wang, Y; Wong, RP | 1 |
| Donachie, AM; Mowat, AM; Robson, NC | 1 |
| Jankovic, J; Le, W; Li, J; Pan, T; Xie, W; Youdim, MB; Zhu, W | 1 |
| Dorn, R; Hausott, B; Klimaschewski, L; Schlick, B; Vallant, N | 1 |
| Ballard, C; Iravani, MM; Jenner, P; MacInnes, N; Perry, E; Perry, R; Piggott, M | 1 |
| Cao, FY; Liu, GP; Liu, YH; Wang, JZ; Wang, Q; Wei, W; Yin, J | 1 |
| Chen, S; Du, Y; Huang, K; Le, W; Li, X; Yang, D; Zhang, X | 1 |
| Hoshino, A; Kawashima, E; Mitome, H; Miyaoka, H; Yamanishi, M | 1 |
| Faustman, EM; Hong, S; Yu, X | 1 |
| Biemesderfer, D; Cong, R; Li, Y | 1 |
| Chen, D; Dou, QP; Landis-Piwowar, KR; Milacic, V; Yang, H | 1 |
| Lim, G; Mao, J; Sung, B; Wang, S; Yang, L | 1 |
| Baek, SJ; Eling, TE; Hara, Y; Lee, SH; McEntee, MF; Sukhthankar, M; Yamaguchi, K | 1 |
| Imamura, K; Ito, S; Nakashima, K; Nakaso, K; Takeshima, T | 1 |
| Harashima, H; Kogure, K; Moriguchi, R; Nakamura, T; Shastri, N | 1 |
| Deng, H; Jankovic, J; Le, W; Pan, T; Xie, W; Zhao, H; Zhu, W | 1 |
| Cardoso, J; Goldenberg, S; Krieger, MA; Le Bloas, R; Menna-Barreto, RF; Soares, MJ; Sotomaior, V | 1 |
| De Caterina, R; Madonna, R; Massaro, M | 1 |
| Artinian, J; De Jaeger, X; Frances, B; McGauran, AM; Mouledous, L; Roullet, P | 1 |
| Jankovic, J; Kondo, S; Le, W; Pan, T; Xie, W; Zhu, W | 1 |
| Choesmel, V; Crétien, A; Da Costa, L; Delaunay, J; Gleizes, PE; Hurtaud, C; Leblanc, T; Marie, I; Mohandas, N; Moniz, H; Proust, A; Tchernia, G; Wagner-Ballon, O | 1 |
| Luo, X; Pan, DJ; Ren, QG; Wang, W; Wang, XZ; Yu, Y | 1 |
| Ding, J; Feng, JM; Miao, ZH; Zhang, XW; Zhu, H | 1 |
| Ekberg, J; Persson, JL | 1 |
| Du, Y; Fan, X; Le, W; Li, X; Luo, G; Yang, D | 1 |
| Pattenden, G; Rescourio, G | 1 |
| Byrne, JH; Fioravante, D; Liu, RY | 1 |
| Fujikake, N; Hamada, M; Hatano, O; Ikeuchi, T; Isosaki, M; Nagai, Y; Nakayama, H; Shimoke, K; Yoshizumi, M; Zhao, J | 1 |
| Hong, HM; Song, EJ; Yoo, YS | 1 |
| Gonzalez-Alegre, P; Gordon, KL | 1 |
| Chai, J; Chen, D; Feng, Y; Gu, L; Huang, N; Huang, S; Huang, Z; Li, W; Wang, X; Wu, X; Xiao, X; Zhong, G | 1 |
| Jie, XM; Luo, X; Pan, DJ; Ren, QG; Wang, W; Yu, Y | 1 |
| Fujisawa, E; Koya, D; Ohshima, S; Sasaoka, T; Tsuneki, H; Wada, T | 1 |
| Hashimoto, T; Ibuki, T; Iwanaga, T; Kishibuchi, R; Kitagawa, H; Mizuguchi, H; Momota, H; Nishihara, S; Onaka, Y; Sado, M; Wada, D; Watanabe, TK; Yamasaki, Y | 1 |
| Li, L; Li, Q; Xu, PF; Yang, SB; Zhang, Z | 1 |
| Moir, RD; Myre, MA; Tanzi, RE; Tesco, G; Wasco, W; Washicosky, K | 1 |
| Fu, JJ; Lin, P; Lv, XY; Tsang, BK; Wang, H; Wang, HX; Yan, XJ; Yu, XG; Zhu, C | 1 |
| Ayala, A; Cadacio, C; D'Aquino-Ardalan, C; Evans, B; Ganapathy, V; Gold, LI; Lecanda, J | 1 |
| Fu, X; Mei, J; Niu, C; Pan, Q | 1 |
| Byfield, R; Garcia, ML; Robek, MD | 1 |
| Millet, V; Moiola, CP; Pasquini, JM; Pasquini, LA; Soto, EF | 1 |
| Du, Y; Fan, X; Le, W; Li, L; Li, T; Luo, G; Wang, Q; Wang, Y; Yang, D; Zhang, X | 1 |
| Harashima, H; Homhuan, A; Kogure, K; Nakamura, T; Shastri, N | 1 |
| Kang, DY; Kim, SH; Kim, TH; Park, KJ; Park, MK; Suh, H; Yoo, YH | 1 |
| Budunova, IV; Chebotaev, DV; Gasparian, AV; Guryanova, OA; Shishkin, AA; Yemelyanov, AY | 1 |
| Adeli, K; Qiu, W; Rutledge, AC; Su, Q; Zhang, J | 1 |
| Tsukamoto, S; Yokosawa, H | 1 |
| Green, MR; Santra, MK; Wajapeyee, N | 1 |
| Chung, RS; Dickson, TC; Staal, JA; Vickers, JC | 1 |
| Qiao, L; Zhang, J | 1 |
| Hou, JC; Pessin, JE; Vicogne, J; Williams, D | 1 |
| Olsnes, S; Wesche, J; Wiedlocha, A; Zakrzewska, M; Zhen, Y | 1 |
| Chen, B; Xu, SL; Zhou, M | 1 |
| Becker, CM; Melzer, N; Oertel, J; Villmann, C | 1 |
| Castaño, A; Gavilán, E; Gavilán, MP; Jiménez, S; Pintado, C; Ríos, RM; Ruano, D; Vitorica, J | 1 |
| Galindo, MF; Jordán, J; Manzanares, J; Perez-Alvarez, S; Solesio, ME | 1 |
| Bamba, H; Hisa, Y; Sato, T; Tooyama, I; Urushitani, M | 1 |
| Andersen, JK; Jankovic, J; Kaur, D; Le, W; Li, X; Luo, F; Xie, W; Zhu, W | 1 |
| Heikkila, JJ; Young, JT | 1 |
| Maeda, Y; Makino, M; Matsuoka, M; Mukai, T; Tamura, T; Tsukamoto, Y | 1 |
| Chen, Y; Ding, Z; Jiang, Y; Ren, H; Su, Y; Wang, J; Wu, J; Yu, W | 1 |
| Kubo, M; Obata, F; Ohta, E | 1 |
| Jackson, T; Jengelley, TA; Jnobaptiste, R; McNaught, KS | 1 |
| Atanasiu, R; Hantouche, C; Shrier, A; Walker, VE; Wong, MJ; Young, JC | 1 |
| Amano, T; Kameyama, N; Mochizuki, H; Nobukuni, M; Okada, S; Sakai, N; Seki, T; Tanaka, A; Yamamoto, H | 1 |
| Braulke, T; Galliciotti, G; Heine, C; Kurze, AK; Mole, SE; Quitsch, A | 1 |
| Endo, T; Hayakawa, M; Hisanaga, S; Miura, Y; Sakurai, Y; Sato, Y; Shimada, Y; Zempel, H | 1 |
| Johansson, SM; Modo, MM; Vernon, AC | 1 |
| Alden, CL; Cardoza, K; Csizmadia, E; Csizmadia, V; Fedyk, ER; Gallacher, M; Kadambi, VJ; O'Brien, L; Raczynski, A; Silverman, L; Simpson, C | 1 |
| Fischer, DF; Hobo, B; van Leeuwen, FW; van Tijn, P; Verhage, MC | 1 |
| Chen, TC; Ghosh, A; Joo, NE; Kapila, YL | 1 |
| David, CS; Patel, R; Rajagopalan, G; Theuer, JE; Tilahun, AY | 1 |
| Qureshi, N; Rockwell, CE | 1 |
| Castellanos, E; Gómez, V; Martínez, JD; Paciucci, R; Santamaría, A; Sesé, M; Soler, M; Thomson, TM | 1 |
| Chen, SD; Lu, GQ; Tan, YY; Wang, G; Wang, ZQ; Zhou, HY | 1 |
| Bengtén, E; Kountikov, E; Miller, NW; Nayak, D; Wilson, M | 1 |
| Biswas, S; Dutta, AK; Le, W; Li, C; Li, X | 1 |
| Guo, Y; Janokovic, J; Le, W; Li, C; Li, X; Xie, W | 1 |
| Crown, D; Leppla, SH; Moayeri, M; Newman, ZL | 1 |
| Inoue, H; Ito, H; Matsui, H; Takahashi, R; Takeda, S; Taniguchi, Y | 1 |
| Jankovic, J; Le, W; Li, C; Li, X; Xie, W; Zhu, W | 1 |
| Cao, X; Qin, K; Wang, T; Xu, Y; Zhang, Z | 1 |
| Chen, MJ; Cheung, NS; Choy, MS; Jenner, AM; Manikandan, J; Melendez, AJ; Peng, ZF | 1 |
| Adachi, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Minamitani, C; Natsume, H; Otsuka, T; Tokuda, H | 1 |
| Barta, A; Janega, P; Parohova, J; Pechanova, O; Simko, F; Vrankova, S | 1 |
| Chen, MJ; Cheung, NS; Chong, KW; Koay, ES; Lee, AY; Russo-Marie, F; Wong, BS | 1 |
| Bui, TN; Efuet, ET; Keyomarsi, K | 1 |
| Amit, T; Bar-Am, O; Prosolovich, K; Weinreb, O; Youdim, MB | 1 |
| Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM | 1 |
| Arawaka, S; Fukushima, S; Hara, S; Kato, T; Koyama, S; Machiya, Y; Sakamoto, M; Sato, H | 1 |
| Endo, A; Endo, M; Gejima, S; Misumi, S; Shoji, S; Takamune, N | 1 |
| Brady, RO; Chen, M; Chiang, J; Hodes, RJ; Iyer, RR; Kaneski, CR; Lonser, RR; Lu, J; Thompson, E; Xu, DS; Yang, C; Zhuang, Z | 1 |
| Gao, G; Luo, H; Wong, J; Zhang, J | 1 |
| Ahn, T; Bae, N; Chung, S; Ko, H; Oh, H; Oh, MS; Park, G; Yang, HO | 1 |
| Hamatani, H; Hiromura, K; Kuroiwa, T; Maeshima, A; Nojima, Y; Sakairi, T; Takahashi, S; Takeuchi, S; Tomioka, M | 1 |
| Amara, A; Arenzana-Seisdedos, F; Bonazzi, M; Cossart, P; Fernandez-Garcia, MD; Meertens, L | 1 |
| Balderas, I; Bermudez-Rattoni, F; Cruz-Castañeda, P; Rodriguez-Ortiz, CJ; Saucedo-Alquicira, F | 1 |
| Traynor, JR; Wang, Q | 1 |
| Ito, H; Matsui, H; Takahashi, R; Takeda, S; Taniguchi, Y | 1 |
| Chaggar, K; Dolphin, AC; Ferron, L; Page, KM; Waithe, D | 1 |
| Li, J; Wu, XM; Zhang, DY | 1 |
| Crum, WR; Johansson, SM; Modo, M; Vernon, AC | 1 |
| Fukushima, H; Hirata, S; Hosokawa, R; Ito, Y; Jimi, E; Katagiri, T; Seo, Y; Zhang, M | 1 |
| Antkiewicz-Michaluk, L; Domin, H; Konieczny, J; Lenda, T; Lorenc-Koci, E; Smiałowska, M; Wardas, J | 1 |
| Cho, SJ; Jo, C; Jo, SA | 1 |
| Guan, XQ; Kisselev, AF; Morrison, DC; Papasian, CJ; Qureshi, AA; Qureshi, N; Reis, J; Van Way, CW; Vogel, SN | 1 |
| Chesnokova, AIu; Ekimova, IV; Iakimchuk, AA; Khudik, KA; Pastukhov, IuF; Romanova, IV | 1 |
| Gui, Y; Jiang, Y; Li, H; Li, J; Yin, H; Zheng, XL | 1 |
| Goodman, SR; Kakhniashvili, DG; Levene, SD; Neelam, S; Wilkens, S | 1 |
| Jantas, D; Kubera, M; Lason, W; Lorenc-Koci, E | 1 |
| Fukaya, M; Kaneki, M; Kim, M; Kitamura, T; Mao, J; Shimizu, N; Shinozaki, S; Tamura, Y; Tanioka, T | 1 |
| Benbow, JH; DeGray, B; Ehrlich, BE | 1 |
| Dai, MF; Hu, D; Zhao, D | 1 |
| Alvarez-Velilla, R; Balaña-Fouce, R; Estrada, CG; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Gu, W; Silverman, RB | 1 |
| Artiukhina, ZE; Ekimova, IV; Guzhova, IV; Pastukhov, IuF; Romanova, IV | 1 |
| Ai, G; Han, Y; Hou, J; Meng, X; Shao, Y; Shi, J; Tao, Y; Wei, R; Wu, X; Zhan, F; Zheng, J | 1 |
| Fujimuro, M; Higashi, C; Niinaka, Y; Noguchi, K; Saji, C; Yamada, K | 1 |
| Jitsukawa, M; Kyogoku, H; Miyano, T; Ogushi, S | 1 |
| Han, HJ; Kim, MO; Suh, HN | 1 |
| Fujita, J; Higashitsuji, H; Itoh, K; Kudo, M; Ryu, U; Sakurai, T | 1 |
| Carroll, CB; Hanemann, CO; Zajicek, JP; Zeissler, ML | 1 |
| Jankovic, J; Kansara, S; Le, WD; Li, XP; Xie, WJ; Zhang, Z | 1 |
| Ann, EJ; Kim, MY; Kim, SM; Mo, JS; Park, HS; Yoon, JH | 1 |
| Azakir, BA; Di Fulvio, S; Kinter, J; Sinnreich, M | 1 |
| Bekier, ME; Borton, MT; Date, D; Dreier, MR; Taylor, WR | 1 |
| Al-Husein, B; Al-Shabrawey, M; Bollag, WB; Choudhary, V; Davis, M; Dong, Z; El Gaish, M; Kaddour-Djebbar, I; Kumar, MV; Lakshmikanthan, V; Shirley, R; Zhong, R | 1 |
| Berger, F; Büchsler, I; Munz, B | 1 |
| Hintermann, S; Jankovic, J; Le, W; Li, X; Tuo, H; Xie, WJ; Zhang, Z | 1 |
| Castaño, A; García-Cuervo, L; Gavilán, E; Gavilán, MP; Gutiérrez, A; Pintado, C; Ríos, RM; Ruano, D; Vitorica, J | 1 |
| Christie, KJ; Martinez, JA; Zochodne, DW | 1 |
| Bajic, N; Ballard, CG; Francis, PT; Jenner, P | 1 |
| Ha, YH; Kim, YE; Kwon, HJ; Lee, Y; Park, JA | 1 |
| Grune, T; Kästle, M; Reeg, S; Rogowska-Wrzesinska, A | 1 |
| Davidge, ST; Lalu, MM; Sankaralingam, S; Xu, H | 1 |
| Grune, T; Kästle, M; Woschee, E | 1 |
| Akatsuka, Y; Demachi-Okamura, A; Kuzushima, K; Miyoshi, H; Torikai, H; Yoshimori, T | 1 |
| Abaturova, SB; Beljelarskaya, SN; Erokhov, PA; Lyupina, YV; Mikhailov, VS; Orlova, OV | 1 |
| Chesnokova, AIu; Mikhrina, AL; Romanova, IV | 1 |
| Jantas, D; Konieczny, J; Kuśmierczyk, J; Lasoń, W; Lenda, T; Lorenc-Koci, E; Roman, A | 1 |
| Berger, H; Hain, T; Schild, H; Tenzer, S | 1 |
| Czyzyk-Krzeska, M; Gozal, D; Kawedia, JD; Menon, AG; Sartor, MA; Yang, F | 1 |
| Huang, KX; Le, WD; Shen, YF; Tang, Y; Zhang, XJ | 1 |
| Fang, B; Guida, WC; Kazi, A; Koomen, J; Lawrence, HR; Marsilio, F; Ozcan, S; Sebti, SM | 1 |
| Dinelle, K; Doudet, DJ; Flores, J; Jing, Y; Mackey, S | 1 |
| Luo, Y; Pengfei, G; Wang, H; Zhang, J; Zhang, S; Zhong, J | 1 |
| Fu, LF; Guan, CP; Hong, WS; Lin, FQ; Liu, JF; Xu, AE; Xu, W; Zhou, MN | 1 |
| Li, A; Lu, Z; Pang, Y; Wu, C; Yin, H; Ying, Z; Yuan, M | 1 |
| Chen, BY; Chen, LW; Duan, L; Gao, GD; Sun, XL; Wang, JJ; Xia, Y; Yung, KK | 1 |
| Abe, A; Ariga, H; Iguchi-Ariga, SM; Kitaura, H; Maita, H; Shimizu, T; Takahashi-Niki, K; Takekoshi, Y | 1 |
| Izumi, Y | 1 |
| Baltrusch, S; Hofmeister-Brix, A; Lenzen, S | 1 |
| Bader, M; Grassner, L; Knight, AM; Loprinzi, CL; Paz, J; Podratz, JL; Staff, NP; Trushina, E; Windebank, AJ | 1 |
| Ishigaki, Y; Matsunaga, T; Nakagawa, H; Nogawa, A; Takegami, T; Zhao, X | 1 |
| Jeng, CJ; Liao, CK; Wang, HS; Wang, SH; Wu, JC | 1 |
| Bury, A; Dexter, DT; Elson, JL; Harrison, IF; Pienaar, IS; Simon, AK; Woll, P | 1 |
| Czarnecka, A; Kamińska, K; Konieczny, J; Lenda, T; Lorenc-Koci, E | 1 |
| Ertürk, A; Sheng, M; Wang, Y | 1 |
| Amoscato, A; Celis, E; Condamine, T; Gabrilovich, DI; Johnson, JJ; Kagan, VE; Klein-Seetharaman, J; Mohammadyani, D; Ramakrishnan, R; Tuyrin, VA; Tyurin, VA; Veglia, F; Zhang, LM | 1 |
| Benetti, F; de Carvalho Myskiw, J; Furini, CR; Izquierdo, I | 1 |
| Arellanes-Robledo, J; Hernández-Nazara, Z; Inagaki, Y; Lakshman, MR; Reyes-Gordillo, K; Rincón-Sánchez, AR; Rojkind, M; Shah, R | 1 |
| Czarnecka, A; Domin, H; Jantas, D; Konieczny, J; Kuter, K; Lasoń, W; Lenda, T; Lorenc-Koci, E; Śmiałowska, M | 1 |
| Bai, L; Chen, Q; Hu, X; Wu, J; Zhang, H; Zhang, L; Zhang, Y | 1 |
| Kirk, CJ; Miller, EJ; Powell, SR | 1 |
| Arellano-Garcia, ME; Hu, S; Misuno, K; Tran, SD | 1 |
| Ekimova, IV; Guzhova, IV; Lapshina, KV; Pastukhov, YF; Plaksina, DV | 1 |
| Cai, Y; Wang, Y; Xu, J; Xu, Y; Zuo, X | 1 |
| Anand, S; Banerjee, P; Bir, A; Cappai, R; Chakrabarti, S; Khemka, VK; Sahoo, A; Sen, O | 1 |
| Li, D; Li, Z; Liu, S; Wang, C; Wang, Y; Xu, Y; Yu, Y; Zeng, L; Zhang, L | 1 |
| Beller, M; Giese, AK; Gläser, A; Lukas, J; Pockrandt, AM; Pohlers, S; Rolfs, A; Runge, F; Seemann, S; Sharif, M; Zheng, C | 1 |
| Matsumoto, A; Ōmura, S; Takahashi, Y; Také, A | 1 |
| Inoue, M; Nagatomo, M; Yoshioka, S | 1 |
| Dai, C; Gao, H; Li, Y; Wang, Y | 1 |
| Czarnecka, A; Kamińska, K; Konieczny, J; Lenda, T; Nowak, P | 1 |
| Aguzzoli, C; Dargél, VA; Dornelles, AS; Falavigna, L; Figueiredo, LS; Köbe, LM; Petry, FS; Roesler, R; Schröder, N | 1 |
| Carbajosa, NA; Congo Carbajosa, NA; Corradi, G; Gironacci, MM; Guil, MJ; Vatta, MS; Verrilli, MA | 1 |
| Cao, W; Kan, Y; Koumbadinga, GA; Lei, L; Lobo, VG; Mahmood, N; Xie, J; Yao, X; Zhang, S | 1 |
| Elson, JL; Pienaar, IS; Yates, A | 1 |
| Crum, WR; Dexter, DT; Harrison, IF; Vernon, AC | 1 |
| Benchimol, M; Gonzaga, L; Menna-Barreto, RF; Pereira-Neves, A | 1 |
| Furini, CR; Izquierdo, I; Myskiw, Jde C; Peixoto, PB; Pereira, LD; Schmidt, BE; Zinn, CG | 1 |
| Adams, B; Essop, MF; Mapanga, RF | 1 |
| Le, W; Xiao, Q; Yang, S | 1 |
| Beart, PM; Cater, MA; Cheung, NS; La Fontaine, S; Llanos, RM; Yap, YW | 1 |
| Campanella, V; Ciaccio, C; Coletta, M; Cozza, P; De Pascali, S; Fanizzi, FP; Marini, S; Sbardella, D; Tarantino, U; Tundo, GR | 1 |
| Huseby, NE; Moens, U; Ravuri, C | 1 |
| Brilot, F; Fonteneau, JF; Gannagé, M; Münz, C | 1 |
| Andressoo, JO; Härma, MA; Jakobson, M; Karalija, N; Kopra, J; Kumar, A; Kuure, S; Lilleväli, K; Lindahl, M; Marshall, P; Mijatovic, J; Ola, R; Palm, E; Panhelainen, A; Piepponen, TP; Porokuokka, LL; Pulkkinen, N; Saarma, M; Strömberg, I; Tekko, T; Varendi, K; Vilenius, C; Võikar, V | 1 |
| Anis, HK; Dexter, DT; Harrison, IF | 1 |
| Dieterich, DC; Elkobi, A; Rosenberg, T; Rosenblum, K | 1 |
| Cott, C; Eierhoff, T; Imberty, A; Juillot, S; Kühn, K; Landi, A; Madl, J; Römer, W; Thuenauer, R | 1 |
| Czarnecka, A; Konieczny, J; Lenda, T | 1 |
| Biebermann, H; Braun, D; Fischer, J; Fuehrer, D; Kleinau, G; Moeller, LC; Schmidt, M; Schweizer, U; Zwanziger, D | 1 |
| Khan, NA; Saleem, S; Siddiqui, R | 1 |
| Cohen, LD; Hakim, V; Ziv, NE; Ziv, T; Zuchman, R | 1 |
| Bousquet-Dubouch, MP; Burlet-Schiltz, O; Chaoui, K; Gonzalez-de-Peredo, A; Marcellin, M; Matondo, M; Monsarrat, B | 1 |
| Myöhänen, TT; Norrbacka, S; Savolainen, MH | 1 |
| Antkiewicz-Michaluk, L; Czarnecka, A; Kamińska, K; Konieczny, J; Lenda, T | 1 |
| Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS | 1 |
| Bentea, E; Churchill, MJ; Deneyer, L; Hood, RL; Massie, A; Meshul, CK; Moore, C; Verbruggen, L | 1 |
| Albertini, G; Andrews, ZB; Aourz, N; Bayliss, JA; Bentea, E; Coppens, J; De Bundel, D; Demuyser, T; Deneyer, L; Massie, A; Portelli, J; Smolders, I; Van Eeckhaut, A; Van Liefferinge, J; Walrave, L | 1 |
| Airavaara, M; Albert, K; Myöhänen, TT; Savolainen, MH | 1 |
| Chen, ZA; Hsiao, IT; Hsu, CH; Huang, SL; Kung, MP; Lin, KJ; Weng, CC; Wey, SP; Yen, TC | 1 |
| Adamcova, M; Aziriova, S; Balazova, L; Celec, P; Krajcirovicova, K; Pechanova, O; Repova, K; Simko, F; Tothova, L; Vrankova, S; Zorad, S | 1 |
| Almeida, MF; Bahr, BA; Farizatto, KLG; Ferrari, MFR; Ikonne, US | 1 |
| Fuchs, PF; Gerwins, P; Heldin, J; Hernández Vera, R; Kreuger, J; O'Callaghan, P | 1 |
| Abdurasulova, IN; Ekimova, IV; Gazizova, AR; Klimenko, VM; Matsulevich, AV; Pastukhov, YF | 1 |
| Almarza, O; Álvarez, A; Antonelli, M; Canales, J; Cerda, O; Peña, MA; Romero, C; Soza, A; Toledo, H; Uribe, F | 1 |
| Hong, L; Huang, Z; Li, H; Miao, B; Na, N; Zhang, J; Zhao, D | 1 |
| Elson, JL; Kochaj, R; Pienaar, IS; Reynolds, R | 1 |
| Basrur, V; Day, SM; Gestwicki, JE; Glazier, AA; Hafeez, N; Helms, AS; Lee, LM; Mellacheruvu, D; Nesvizhskii, AI; Shao, H; Tang, V; Yob, JM | 1 |
| Chatterjee Bhowmick, D; Jeremic, A | 1 |
| Antkiewicz-Michaluk, L; Nalepa, I; Romańska, I; Wąsik, A; Zelek-Molik, A | 1 |
| Ekimova, IV; Plaksina, DV | 1 |
| Bharadwaj, AG; Cohen, AM; Holloway, RW; Marcato, P; Marignani, PA; Rahman, M; Thomas, ML; Waisman, DM | 1 |
| Dexter, DT; Harrison, IF; Powell, NM | 1 |
| Alstrup, AKO; Doudet, DJ; Glud, AN; Kirik, D; Landau, AM; Landeck, N; Lillethorup, TP; Nielsen, EHT; Noer, O; Orlowski, D; Schacht, AC; Sørensen, JCH | 1 |
| Crump, A; Ōmura, S | 1 |
| Hou, Y; Ji, X; Jiang, H; Leng, X; Settlage, R | 1 |
| Arbiza, J; Campos, D; González-Santamaría, J; Llamas-González, YY; Pascale, JM | 1 |
| Han, K; Huang, X; Li, Y; Liu, Q; Liu, Y; Yang, J; Zhang, L; Zhao, D | 1 |
| Nagatomo, M | 1 |
| Daude, N; Kang, SG; Kar, S; Mays, CE; Westaway, D; Yang, J | 1 |
| Bonet-Costa, V; Davies, KJA; Sun, PY | 1 |
| Lindholm, D; Myöhänen, TT; Norrbacka, S | 1 |
| Albertini, G; Bentea, E; Deneyer, L; Massie, A | 1 |
| Haapasalo, A; Hiltunen, M; Huber, N; Leskelä, S; Natunen, T; Remes, AM; Rostalski, H; Takalo, M | 1 |
| Brandel, J; Dexter, DT; Elson, JL; Fairooz, S; Hubscher-Bruder, V; Lewis, FW; Pienaar, IS; Smith, D; Soundararajan, M; Tétard, D | 1 |
| Lee, BH; Nicola, AV; Schneider, SM | 1 |
| Du, Y; Guan, Y; Hao, Y; Le, W; Li, Z; Song, Y; Wang, F; Yang, X | 1 |
| Audard, V; Fan, Q; Henique, C; Moktefi, A; Ollero, M; Ory, V; Pawlak, A; Sahali, D; Zhang, SY | 1 |
21 review(s) available for acetylcysteine and lactacystin
| Article | Year |
|---|---|
[Differentiation inducing compounds].
Topics: Acetylcysteine; Alkaloids; Animals; Anthraquinones; Blood Cells; Cell Differentiation; Cells, Cultured; Humans; Leukemia, Experimental; Neuroblastoma; Purine Nucleosides; Ribonucleosides; Sesquiterpenes; Staurosporine | 1993 |
[Lactacystin: a tool for elucidation of proteasome functions].
Topics: Acetylcysteine; Animals; Binding Sites; Cell Cycle; Cell Differentiation; Cysteine Endopeptidases; Dendrites; Humans; Multienzyme Complexes; Neurons; Proteasome Endopeptidase Complex; Protein Binding | 1996 |
Lactacystin, proteasome function, and cell fate.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Cycle; Cell Line; Cell Physiological Phenomena; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Mice; Multienzyme Complexes; Neurites; Neuroblastoma; Proteasome Endopeptidase Complex | 1998 |
Proteasome inhibitors: valuable new tools for cell biologists.
Topics: Acetylcysteine; Animals; Antigen Presentation; Boron Compounds; Cysteine Endopeptidases; Depression, Chemical; Endopeptidases; Heat-Shock Proteins; Humans; Leupeptins; Mammals; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteins; Sulfones; Ubiquitins; Yeasts | 1998 |
Ubiquitin-proteasome system and increased sensitivity of B-CLL lymphocytes to apoptotic death activation.
Topics: Acetylcysteine; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Multienzyme Complexes; Proteasome Endopeptidase Complex; Signal Transduction; Ubiquitins | 2000 |
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology.
Topics: Acetylcysteine; Animals; Antigen Presentation; Cell Cycle Proteins; Cell Differentiation; Cell Physiological Phenomena; Circadian Rhythm; Cysteine Endopeptidases; Endoplasmic Reticulum; Lactones; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Structure-Activity Relationship; Ubiquitins | 2000 |
Proteasome inhibitors.
Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Humans; Hydrolysis; Inflammation; Isocoumarins; Macromolecular Substances; Molecular Weight; Multienzyme Complexes; Neoplasms; Peptides; Proteasome Endopeptidase Complex; Substrate Specificity | 2002 |
Proteasome inhibitors: complex tools for a complex enzyme.
Topics: Acetylcysteine; Affinity Labels; Animals; Catalysis; Cysteine Endopeptidases; Drug Design; Humans; Molecular Structure; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Structure-Activity Relationship; Substrate Specificity | 2002 |
Proteasome inhibitors in the treatment of B-cell malignancies.
Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Cycle Proteins; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Enzymes; Gene Expression Regulation; Hodgkin Disease; Humans; Leukemia, B-Cell; Leupeptins; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Mice; Multiple Myeloma; Neoplasm Proteins; NF-kappa B; Oncogene Proteins; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Substrate Specificity; Transcription Factors; Treatment Outcome | 2002 |
[Synthetic studies of microbial natural products from microorganisms].
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Drug Design; Gastrointestinal Agents; Heterocyclic Compounds; Humans; Indoles; Macrolides; Motilin; Peristalsis; Pyrans; Pyridines; Sesquiterpenes; Sterol O-Acyltransferase; Structure-Activity Relationship | 2003 |
The proteasome: a central regulator of inflammation and macrophage function.
Topics: Acetylcysteine; Aging; Animals; Atherosclerosis; Cholesterol; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Shock, Hemorrhagic; Signal Transduction; Toll-Like Receptor 2 | 2005 |
Anti-angiogenic and anti-tumor properties of proteasome inhibitors.
Topics: Acetylcysteine; Angiogenesis Inhibitors; Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Neoplasms; Neovascularization, Pathologic; Protease Inhibitors; Proteasome Inhibitors; Pyrazines | 2005 |
Total synthesis of lactacystin and salinosporamide A.
Topics: Acetylcysteine; Enzyme Inhibitors; Lactones; Molecular Structure; Proteasome Inhibitors; Pyrroles; Stereoisomerism | 2007 |
Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Boronic Acids; Bortezomib; Clinical Trials as Topic; Curcumin; Humans; Neoplasms; Pentacyclic Triterpenes; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Triterpenes; Ubiquitin | 2008 |
Targeting the proteasome pathway.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Biological Products; Boronic Acids; Bortezomib; Drug Delivery Systems; Drug Discovery; Humans; Lactones; Neoplasms; Peptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrroles; Structure-Activity Relationship; Ubiquitin; Ubiquitin-Activating Enzymes; Ubiquitins | 2009 |
[Classification and synthesis of ubiquitin-proteasome inhibitor].
Topics: Acetylcysteine; Antineoplastic Agents; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Multiple Myeloma; Peptides, Cyclic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Ubiquitin | 2009 |
[Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves].
Topics: Acetylcysteine; Animals; Antioxidant Response Elements; Cell Death; Chalcones; Dopaminergic Neurons; NF-E2-Related Factor 2; Oxidative Stress; Oxidopamine; Parkinson Disease; Perilla; Proteasome Endopeptidase Complex; Rats | 2013 |
Comparative Microarray Analysis Identifies Commonalities in Neuronal Injury: Evidence for Oxidative Stress, Dysfunction of Calcium Signalling, and Inhibition of Autophagy-Lysosomal Pathway.
Topics: Acetylcysteine; Animals; Autophagy; Calcium Signaling; Humans; Lysosomes; Microarray Analysis; Neurodegenerative Diseases; Neurons; Oxidative Stress; Pesticides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, N-Methyl-D-Aspartate; Rotenone; Ubiquitin | 2016 |
Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Biological Products; Dementia; Drug Discovery; Humans; Neoplasms; Neuroprotective Agents; Proteasome Inhibitors | 2019 |
[Development of Synthetic Strategies for Densely Oxygenated Natural Products: Total Synthesis of Lactacystin and Zaragozic Acid C Using Photochemical C(sp
Topics: Acetylcysteine; Acylation; Alkylation; Biological Products; Bridged Bicyclo Compounds, Heterocyclic; Carbon; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Free Radicals; Gluconates; Lactones; Oxidation-Reduction; Oxygen; Photochemical Processes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Stereoisomerism | 2019 |
Viral entry and the ubiquitin-proteasome system.
Topics: Acetylcysteine; Animals; Antiviral Agents; Bortezomib; Host Microbial Interactions; Humans; Leupeptins; Nucleocapsid; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ubiquitin; Virion; Virus Internalization; Virus Physiological Phenomena; Viruses | 2021 |
865 other study(ies) available for acetylcysteine and lactacystin
| Article | Year |
|---|---|
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adrenergic Agents; Animals; Cell Nucleus; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Glutathione; Hydrogen Peroxide; Imidazoles; Models, Biological; NF-E2 Transcription Factor; Oxidants; Oxidative Stress; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Ubiquitin | 2007 |
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cyclic AMP; Microscopy, Electron; Molecular Conformation; Molecular Structure; Neuroblastoma; Neurons; Streptomyces; Tumor Cells, Cultured | 1991 |
Structure of lactacystin, a new microbial metabolite which induces differentiation of neuroblastoma cells.
Topics: Acetylcysteine; Anti-Bacterial Agents; Cell Differentiation; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Neuroblastoma; Neurons; Streptomyces; Tumor Cells, Cultured; X-Ray Diffraction | 1991 |
Neuronal differentiation of Neuro 2a cells by lactacystin and its partial inhibition by the protein phosphatase inhibitors calyculin A and okadaic acid.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Antifungal Agents; Biomarkers; Bucladesine; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Ethers, Cyclic; Hydroquinones; Kinetics; Marine Toxins; Neurites; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Pyrans; Spiro Compounds; Time Factors | 1995 |
Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway.
Topics: Acetylcysteine; Animals; Chloroquine; Cysteine Endopeptidases; Dipeptides; Humans; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rabbits; Receptors, Platelet-Derived Growth Factor; Swine; Ubiquitins | 1995 |
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing.
Topics: Acetylcysteine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endopeptidases; Endoplasmic Reticulum; Humans; Leupeptins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Ubiquitins | 1995 |
Biosynthesis of lactacystin.
Topics: Acetylcysteine; Anti-Bacterial Agents; Cysteine Proteinase Inhibitors; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Streptomyces | 1995 |
Structure-activity relationships of lactacystin, the first non-protein neurotrophic factor.
Topics: Acetylcysteine; Anti-Bacterial Agents; Structure-Activity Relationship | 1995 |
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Mice; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Proteasome Endopeptidase Complex; Threonine; Tumor Cells, Cultured | 1995 |
The neuritogenesis inducer lactacystin arrests cell cycle at both G0/G1 and G2 phases in neuro 2a cells.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; G1 Phase; G2 Phase; Kinetics; Mice; Neuroblastoma; Resting Phase, Cell Cycle; Tumor Cells, Cultured | 1995 |
A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line.
Topics: Acetylcysteine; Anti-Bacterial Agents; Cell Cycle; Cytoskeleton; Humans; In Vitro Techniques; Lactones; Neurites; Neuroblastoma; Osteosarcoma; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Ligand-activated platelet-derived growth factor beta-receptor is degraded through proteasome-dependent proteolytic pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Ligands; Multienzyme Complexes; Oligopeptides; Phosphorylation; Proteasome Endopeptidase Complex; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Swine; Ubiquitins | 1995 |
Lactacystin, a specific inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells.
Topics: Acetylcysteine; Apoptosis; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; Humans; Monocytes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1995 |
Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Lactones; Molecular Structure; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rabbits; Reticulocytes; Streptomyces | 1996 |
Lactacystin, an inhibitor of the proteasome, blocks the degradation of a mutant precursor of glycosylphosphatidylinositol-linked protein in a pre-Golgi compartment.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chlorocebus aethiops; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum Chaperone BiP; Glycosylphosphatidylinositols; Golgi Apparatus; Heat-Shock Proteins; Kinetics; Molecular Chaperones; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Recombinant Fusion Proteins | 1996 |
In vivo ubiquitination and proteasome-mediated degradation of p53(1).
Topics: Acetylcysteine; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; RNA, Messenger; Tumor Suppressor Protein p53; Ubiquitins | 1996 |
Proteasomes play an essential role in thymocyte apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; DNA Ligases; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes | 1996 |
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium-Binding Proteins; Caspase 1; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Ligases; Electrophoresis, Polyacrylamide Gel; Leupeptins; Multienzyme Complexes; Nerve Growth Factors; Neurons; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Rats; Sympathetic Nervous System | 1996 |
Accelerated degradation of PML-retinoic acid receptor alpha (PML-RARA) oncoprotein by all-trans-retinoic acid in acute promyelocytic leukemia: possible role of the proteasome pathway.
Topics: Acetylcysteine; Animals; Antibodies; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Stability; Humans; Immunoblotting; Leukemia, Promyelocytic, Acute; Neoplasm Proteins; Nuclear Proteins; Oncogene Proteins, Fusion; Promyelocytic Leukemia Protein; Rabbits; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Transcription Factors; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1996 |
Proteasome pathway operates for the degradation of ornithine decarboxylase in intact cells.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation, Enzymologic; Multienzyme Complexes; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Osmotic Pressure; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1996 |
Ubiquitination of protein kinase C-alpha and degradation by the proteasome.
Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Sequence; Animals; Bryostatins; Cells, Cultured; Cysteine Endopeptidases; Cytosol; Down-Regulation; Hydrolysis; Isoenzymes; Lactones; Leucine; Macaca mulatta; Macrolides; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-alpha; Ubiquitins | 1996 |
Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity.
Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Calcium-Binding Proteins; Calnexin; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Endoplasmic Reticulum; Fibroblasts; Hexosaminidases; Humans; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rabbits | 1996 |
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.
Topics: Acetylcysteine; Benzoquinones; Biopolymers; Breast Neoplasms; Cell Line; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Humans; Lactams, Macrocyclic; Molecular Weight; Multienzyme Complexes; Polyubiquitin; Proteasome Endopeptidase Complex; Quinones; Receptor, ErbB-2; Rifabutin; Ubiquitins | 1996 |
Degradation of 3-hydroxy-3-methylglutaryl-CoA reductase in endoplasmic reticulum membranes is accelerated as a result of increased susceptibility to proteolysis.
Topics: Acetylcysteine; Animals; Cell Fractionation; Cell Line, Transformed; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Endopeptidases; Endoplasmic Reticulum; Enzyme Inhibitors; Enzyme Stability; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Intracellular Membranes; Kidney; Kinetics; Mevalonic Acid; Multienzyme Complexes; Proteasome Endopeptidase Complex; Thermodynamics | 1996 |
Proteasome-dependent regulation of p21WAF1/CIP1 expression.
Topics: Acetylcysteine; Cell Line; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Luciferases; Multienzyme Complexes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Protein Biosynthesis; Recombinant Proteins; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
Lactacystin increases LDL receptor level on HepG2 cells.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multienzyme Complexes; Proteasome Endopeptidase Complex; Receptors, LDL; Tumor Cells, Cultured; Up-Regulation | 1996 |
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae.
Topics: Acetylcysteine; Animals; Kinetics; Leupeptins; Mammals; Muramidase; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Ubiquitins; Vacuoles | 1996 |
Proteasome activity is required for the stage-specific transformation of a protozoan parasite.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Multienzyme Complexes; Proteasome Endopeptidase Complex; Trypanosoma cruzi | 1996 |
Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells.
Topics: Acetylcysteine; Chymotrypsin; Cysteine Endopeptidases; Enzyme Inhibitors; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Binding; Substrate Specificity; Tumor Cells, Cultured | 1996 |
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate.
Topics: Acetylcysteine; Adenosine Triphosphate; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Fungal Proteins; Genes, Fungal; Isocoumarins; Kinetics; Microsomes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity | 1996 |
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase.
Topics: Acetylcysteine; Blotting, Western; Cell Nucleus; Cysteine Endopeptidases; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Humans; Interferon-gamma; Leupeptins; Multienzyme Complexes; Nuclear Proteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor; Staurosporine; Trans-Activators; Vanadates | 1996 |
Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells.
Topics: Acetylcysteine; Biological Transport; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glutathione; HeLa Cells; Humans; Lactones; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Pyrrolidinones; Tumor Cells, Cultured | 1997 |
Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Animals; Brefeldin A; Cell Line; Cell Membrane; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hepatocyte Growth Factor; Humans; Ligands; Molecular Weight; Multienzyme Complexes; Nerve Growth Factors; Peptide Fragments; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transfection; Ubiquitins | 1997 |
The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
Topics: Acetylcysteine; Animals; Antigen-Presenting Cells; Antigens, Viral; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Epitopes; H-2 Antigens; Humans; Leupeptins; Mice; Multienzyme Complexes; Nucleocapsid Proteins; Nucleoproteins; Orthomyxoviridae; Peptides; Proteasome Endopeptidase Complex; Signal Transduction; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Core Proteins | 1997 |
Rapid degradation of CD4 in cells expressing human immunodeficiency virus type 1 Env and Vpu is blocked by proteasome inhibitors.
Topics: Acetylcysteine; Amino Acid Sequence; Brefeldin A; CD4 Antigens; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Products, env; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Signal Transduction; Viral Regulatory and Accessory Proteins | 1997 |
Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome.
Topics: Acetylcysteine; beta 2-Microglobulin; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Histocompatibility Antigens Class I; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Folding; Solubility; Transfection; Tumor Cells, Cultured | 1997 |
Bryostatin 1 and phorbol ester down-modulate protein kinase C-alpha and -epsilon via the ubiquitin/proteasome pathway in human fibroblasts.
Topics: Acetylcysteine; Bryostatins; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Fibroblasts; Glycoproteins; Humans; Isoenzymes; Lactones; Macrolides; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Ubiquitins | 1997 |
Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance.
Topics: Acetylcysteine; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Endoplasmic Reticulum; Fungal Proteins; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Glycoproteins; Membrane Proteins; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; RNA, Messenger | 1997 |
Structure of 20S proteasome from yeast at 2.4 A resolution.
Topics: Acetylcysteine; Calpain; Crystallography, X-Ray; Cysteine Endopeptidases; Endopeptidases; Enzyme Inhibitors; Enzyme Precursors; Glycoproteins; Histocompatibility Antigens Class I; Models, Molecular; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Conformation; Saccharomyces cerevisiae; Thermoplasma; Threonine | 1997 |
Evidence of proteasome-mediated cytochrome P-450 degradation.
Topics: Acetylcysteine; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Leupeptins; Microsomes, Liver; Mixed Function Oxygenases; Multienzyme Complexes; Oxidoreductases, N-Demethylating; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 1997 |
Angiotensin II-induced down-regulation of inositol trisphosphate receptors in WB rat liver epithelial cells. Evidence for involvement of the proteasome pathway.
Topics: Acetylcysteine; Angiotensin II; Animals; Calcium Channels; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Receptors, Cytoplasmic and Nuclear; Ubiquitins | 1997 |
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antigen Presentation; Base Sequence; beta-Lactams; Cell Line; Cricetinae; Cysteine Endopeptidases; Histocompatibility Antigens Class I; Humans; Lactones; Mice; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex | 1997 |
Regulation of p53 stability by Mdm2.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Humans; Mice; Multienzyme Complexes; Mutation; Nuclear Proteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1997 |
Lactacystin, a specific inhibitor of the proteasome, inhibits human platelet lysosomal cathepsin A-like enzyme.
Topics: Acetylcysteine; Blood Platelets; Carboxypeptidases; Catalysis; Cathepsin A; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Kinetics; Lysosomes; Multienzyme Complexes; Proteasome Endopeptidase Complex | 1997 |
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Calcimycin; Calcium-Binding Proteins; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Embryo, Mammalian; Humans; Kidney; Peptide Fragments; Transfection | 1997 |
Proteasome regulation of activation-induced T cell death.
Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fas Ligand Protein; Humans; Lymphocyte Activation; Membrane Glycoproteins; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes | 1997 |
Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune system.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cysteine Endopeptidases; Histocompatibility Antigens Class I; Humans; Immunocompetence; Interferon-gamma; Ligands; Molecular Sequence Data; Multienzyme Complexes; Peptide Fragments; Proteasome Endopeptidase Complex; Rabbits | 1997 |
Regulation of IkappaB beta in WEHI 231 mature B cells.
Topics: Acetylcysteine; Antioxidants; B-Lymphocytes; Biological Transport; Cell Line; Cell Nucleus; Chymotrypsin; Cysteine Proteinase Inhibitors; Cytosol; DNA; Enzyme Inhibitors; Feedback; Glycoproteins; Lipopolysaccharides; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Pyrrolidines; RNA, Messenger; Thiocarbamates; Tosylphenylalanyl Chloromethyl Ketone; Transcription Factor RelB; Transcription Factors | 1997 |
Evidence for participation of a calpain-like cysteine protease in cell cycle progression through late G1 phase.
Topics: Acetylcysteine; Calpain; Cell Cycle; Cell Line; Cysteine Proteinase Inhibitors; Diazomethane; Fibroblasts; G1 Phase; Humans; Leupeptins; Oligopeptides; S Phase | 1997 |
The alpha chain of the T cell antigen receptor is degraded in the cytosol.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cell Compartmentation; COS Cells; Cysteine Proteinase Inhibitors; Cytosol; Detergents; Endoplasmic Reticulum; Glycosylation; Lactams; Protein Conformation; Protein Folding; Receptors, Antigen, T-Cell, alpha-beta; Trypsin | 1997 |
Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions.
Topics: Acetylcysteine; Animals; Cadherins; Cell Movement; Cells, Cultured; Cysteine Endopeptidases; Endothelium, Vascular; Humans; Intercellular Junctions; Mice; Multienzyme Complexes; Neutrophils; Proteasome Endopeptidase Complex; Tumor Necrosis Factor-alpha | 1997 |
Intracellular degradation of secretion defect-type mutants of antithrombin is inhibited by proteasomal inhibitors.
Topics: Acetylcysteine; Animals; Antithrombin III; Brefeldin A; Cell Line; Cricetinae; Cyclopentanes; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Fluorescent Antibody Technique; Golgi Apparatus; Humans; Kidney; Leupeptins; Multienzyme Complexes; Mutagenesis, Site-Directed; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Transfection | 1997 |
Transcriptional squelching by ectopic expression of E2F-1 and p53 is alleviated by proteasome inhibitors MG-132 and lactacystin.
Topics: Acetylcysteine; Animals; beta-Galactosidase; Blotting, Northern; Carrier Proteins; Cell Cycle Proteins; CHO Cells; Cricetinae; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Leupeptins; Oligopeptides; Protein Synthesis Inhibitors; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
MHC class I presentation of an exogenous polypeptide antigen encoded by the murine AIDS defective virus.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Antiviral Agents; Brefeldin A; Cathepsin B; CD8-Positive T-Lymphocytes; Cyclopentanes; Cysteine Proteinase Inhibitors; Cytochalasin B; Cytochalasin D; Dipeptides; Female; Gene Products, gag; H-2 Antigens; Interleukin-2; Leukemia Virus, Murine; Major Histocompatibility Complex; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Murine Acquired Immunodeficiency Syndrome; Nucleic Acid Synthesis Inhibitors; Plant Proteins; Protein Synthesis Inhibitors; Ribosome Inactivating Proteins, Type 1 | 1997 |
The effect of the proteasome inhibitor lactacystin on the presentation of transporter associated with antigen processing (TAP)-dependent and TAP-independent peptide epitopes by class I molecules.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cysteine Endopeptidases; Endoplasmic Reticulum; Epitopes; Hexosaminidases; Histocompatibility Antigens Class I; HLA-A2 Antigen; Humans; Leupeptins; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Sorting Signals; Self Tolerance; T-Lymphocytes, Cytotoxic | 1997 |
Apoptosis of Ewing's sarcoma cells is accompanied by accumulation of ubiquitinated proteins.
Topics: Acetylcysteine; Apoptosis; Cysteine Endopeptidases; DNA Fragmentation; Enzyme Inhibitors; Gene Expression; Humans; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Sarcoma, Ewing; Tumor Cells, Cultured; Ubiquitins | 1997 |
Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium-Binding Proteins; Cell Line; Cysteine Proteinase Inhibitors; DNA Probes; Glutathione Transferase; Liver; Membrane Glycoproteins; Mice; Microinjections; Nerve Tissue Proteins; NF-kappa B; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Synaptotagmin I; Synaptotagmins; Transcription Factor RelB; Transcription Factors | 1997 |
Proteasome regulation of Fas ligand cytotoxicity.
Topics: Acetylcysteine; Animals; CD3 Complex; Cysteine Endopeptidases; DNA-Binding Proteins; Fas Ligand Protein; Genes, Immediate-Early; I-kappa B Proteins; Interleukin-2; Membrane Glycoproteins; Mice; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Nuclear Proteins; Proteasome Endopeptidase Complex; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes | 1997 |
Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein.
Topics: Acetylcysteine; AIDS Vaccines; Antigen Presentation; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Histocompatibility Antigens Class I; HIV; HIV Envelope Protein gp120; Multienzyme Complexes; Peptide Fragments; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; T-Lymphocytes, Cytotoxic | 1997 |
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Brefeldin A; Calcium-Binding Proteins; Cell Line; Chloroquine; Cyclopentanes; Cysteine Endopeptidases; Dogs; Endosomal Sorting Complexes Required for Transport; Endosomes; Epithelial Sodium Channels; Epithelium; Half-Life; Ion Channel Gating; Ion Transport; Ligases; Lysosomes; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Site-Directed; Mutation; Nedd4 Ubiquitin Protein Ligases; Nuclear Magnetic Resonance, Biomolecular; Oocytes; Point Mutation; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Conformation; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Sodium; Sodium Channels; Transfection; Ubiquitin-Protein Ligases; Ubiquitins; Up-Regulation; Xenopus laevis; Xenopus Proteins | 1997 |
Regulation of cyclin D1 by calpain protease.
Topics: 3T3 Cells; Acetylcysteine; Animals; Calpain; Cyclin B; Cyclin B1; Cyclin D1; Cysteine Proteinase Inhibitors; Dactinomycin; Half-Life; Humans; Male; Mice; Prostatic Neoplasms; Protein Synthesis Inhibitors; Tumor Cells, Cultured | 1997 |
Degradation of the inducible cAMP early repressor (ICER) by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Animals; Cell Line; Cyclic AMP; Cyclic AMP Response Element Modulator; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Ion Channels; Leupeptins; Multienzyme Complexes; Myocardium; Neurons; Proteasome Endopeptidase Complex; Rats; Repressor Proteins; Transcription, Genetic; Ubiquitins | 1997 |
Degradation of hepatic stearyl CoA delta 9-desaturase.
Topics: Acetylcysteine; Animals; Calpain; Cell Fractionation; Cysteine Proteinase Inhibitors; Hydrogen-Ion Concentration; Liver; Lysosomes; Male; Microsomes; Molecular Weight; Rats; Rats, Sprague-Dawley; Sequence Analysis; Serine Proteinase Inhibitors; Stearoyl-CoA Desaturase; Temperature | 1997 |
Specificities of cell permeant peptidyl inhibitors for the proteinase activities of mu-calpain and the 20 S proteasome.
Topics: Acetylcysteine; Calcium-Binding Proteins; Calpain; Catalysis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diazomethane; Enzyme Precursors; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Muramidase; Oligopeptides; Plant Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Serine Proteinase Inhibitors; Ubiquitins | 1997 |
Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Inhibitors; Humans; Multienzyme Complexes; Oligopeptides; PC12 Cells; Phorbol 12,13-Dibutyrate; Proteasome Endopeptidase Complex; Protein Kinase C; Rats; Time Factors | 1997 |
Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: effects on replication, transcription, translation, and the cellular stress response.
Topics: Acetylcysteine; Breast Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; DNA Replication; Female; Histones; Hot Temperature; Humans; Leupeptins; Multienzyme Complexes; Nucleoproteins; Nucleosomes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitins | 1997 |
Differential regulation of the pocket domains of the retinoblastoma family proteins by the HPV16 E7 oncoprotein.
Topics: Acetylcysteine; Adenovirus E1A Proteins; Antigens, Polyomavirus Transforming; Cell Line; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Humans; Nuclear Proteins; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Peptide Hydrolases; Proteasome Endopeptidase Complex; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Transfection | 1997 |
Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cecum; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Kinetics; Leupeptins; Male; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis; Transcription, Genetic; Ubiquitins | 1998 |
Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Compartmentation; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kidney; Leupeptins; Lysosomes; Microscopy, Confocal; Multienzyme Complexes; Opossums; Parathyroid Hormone; Phosphates; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type II; Symporters | 1998 |
Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Flow Cytometry; Interphase; Leupeptins; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; S Phase; Trypanosoma brucei brucei | 1997 |
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis.
Topics: Acetylcysteine; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Leupeptins; Lymphoma; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1998 |
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway.
Topics: Acetylcysteine; Calcium-Binding Proteins; Calnexin; CD4 Antigens; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Cytosol; Enzyme Activation; Glycoproteins; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Leupeptins; Multienzyme Complexes; Mutagenesis; Proteasome Endopeptidase Complex; Ubiquitins; Viral Regulatory and Accessory Proteins | 1998 |
In vivo degradation of N-myc in neuroblastoma cells is mediated by the 26S proteasome.
Topics: Acetylcysteine; Calpain; Cysteine Proteinase Inhibitors; Humans; Lysosomes; Neuroblastoma; Peptide Hydrolases; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-myc; Substrate Specificity; Tumor Cells, Cultured; Ubiquitins | 1998 |
Gene expression of the proteasome in rat lens development.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Lens, Crystalline; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Selective involvement of proteasomes and cysteine proteases in MHC class I antigen presentation.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytomegalovirus; Hepatitis B e Antigens; Histocompatibility Antigens Class I; Immediate-Early Proteins; Immunodominant Epitopes; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis, Insertional; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Vaccinia virus | 1997 |
Role of proteasomes in T cell activation and proliferation.
Topics: Acetylcysteine; Apoptosis; B-Lymphocytes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; G1 Phase; Humans; Interphase; Jurkat Cells; Lymphocyte Activation; Microtubule-Associated Proteins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Receptors, Interleukin-2; S Phase; T-Lymphocytes; Tumor Suppressor Proteins; Up-Regulation | 1998 |
Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1.
Topics: Acetylcysteine; beta-Galactosidase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Viral; Gene Products, tat; HeLa Cells; HIV Core Protein p24; HIV-1; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; tat Gene Products, Human Immunodeficiency Virus; Tumor Cells, Cultured | 1998 |
Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Kidney; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Peptide Fragments; Presenilin-1; Proteasome Endopeptidase Complex; Ubiquitins | 1998 |
The proteasome inhibitor lactacystin induces apoptosis and sensitizes chemo- and radioresistant human chronic lymphocytic leukaemia lymphocytes to TNF-alpha-initiated apoptosis.
Topics: Acetylcysteine; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Multienzyme Complexes; Neoplasm Proteins; NF-kappa B; Proteasome Endopeptidase Complex; Radiation Tolerance; Tumor Necrosis Factor-alpha | 1998 |
Proteasome and thiol involvement in quality control of glycosylphosphatidylinositol anchor addition.
Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylphosphatidylinositols; Human Growth Hormone; Humans; Leupeptins; Multienzyme Complexes; Mutation; Peptides; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sulfhydryl Compounds; Ubiquitins | 1998 |
Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.
Topics: Acetylcysteine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Brain; Cells, Cultured; Cycloheximide; Fibroblasts; Humans; Isoenzymes; Peptide Fragments; Protein Kinase C; Protein Kinase C-alpha; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate | 1998 |
Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control.
Topics: Acetylcysteine; Adenoviridae; Animals; Animals, Newborn; Cell Cycle; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Gene Expression Regulation; Keratinocytes; Leupeptins; Membrane Proteins; Mice; Mutation; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Succinates; Transfection | 1998 |
Characterization of human CD8+ T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; CD8-Positive T-Lymphocytes; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Lymphocyte Cooperation; Mice; Molecular Sequence Data; Mycobacterium tuberculosis; Tuberculosis | 1998 |
Dissociation of proteasomal degradation of biosynthesized viral proteins from generation of MHC class I-associated antigenic peptides.
Topics: Acetylcysteine; Animals; Antigen Presentation; Cysteine Endopeptidases; Histocompatibility Antigens Class I; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Multienzyme Complexes; Ovalbumin; Peptide Fragments; Proteasome Endopeptidase Complex; Recombinant Proteins; Tumor Cells, Cultured; Viral Proteins | 1998 |
Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Deferoxamine; Membrane Proteins; Nerve Tissue Proteins; Neurons; Phosphodiesterase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Superior Cervical Ganglion | 1998 |
The proteasome is involved in angiogenesis.
Topics: Acetylcysteine; Allantois; Animals; Cells, Cultured; Chick Embryo; Chorion; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Humans; Multienzyme Complexes; Neovascularization, Physiologic; Plasminogen Activators; Proteasome Endopeptidase Complex | 1998 |
Effects of tocotrienol on the intracellular translocation and degradation of apolipoprotein B: possible involvement of a proteasome independent pathway.
Topics: Acetylcysteine; Apolipoproteins B; Biological Transport; Cell Membrane Permeability; Chromans; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leupeptins; Liver; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Tumor Cells, Cultured; Vitamin E | 1998 |
Inhibition of glucose trimming with castanospermine reduces calnexin association and promotes proteasome degradation of the alpha-subunit of the nicotinic acetylcholine receptor.
Topics: Acetylcysteine; Biopolymers; Calcium-Binding Proteins; Calnexin; Calreticulin; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimerization; DNA, Complementary; Glucose; Heat-Shock Proteins; Humans; Hydrolysis; Indolizines; Isomerases; Leupeptins; Multienzyme Complexes; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Binding; Protein Disulfide-Isomerases; Receptors, Nicotinic; Ribonucleoproteins; Transfection; Ubiquitins | 1998 |
Proteasomes can either generate or destroy MHC class I epitopes: evidence for nonproteasomal epitope generation in the cytosol.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Glycine; Histocompatibility Antigens Class I; HLA-A Antigens; Humans; Leupeptins; Membrane Proteins; Mice; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Time Factors; Viral Matrix Proteins | 1998 |
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway.
Topics: Acetylcysteine; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leupeptins; Neuroblastoma; Oncogene Proteins, Viral; Papillomaviridae; Papillomavirus Infections; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Tumor Virus Infections; Ubiquitins | 1998 |
The role of proteolysis during differentiation of Trypanosoma brucei from the bloodstream to the procyclic form.
Topics: Acetylcysteine; Animals; Blood; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzymes; Glycolysis; Multienzyme Complexes; Proteasome Endopeptidase Complex; Trypanosoma brucei brucei; Variant Surface Glycoproteins, Trypanosoma | 1998 |
Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA.
Topics: Acetylcysteine; Anti-Bacterial Agents; Brefeldin A; Cell Fractionation; Cell Line; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Golgi Apparatus; Histocompatibility Antigens Class II; HLA-B27 Antigen; Humans; Kidney; Macrolides; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Recombinant Fusion Proteins | 1998 |
Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats.
Topics: Acetylcysteine; Animals; Burns; Culture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Lactones; Leupeptins; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tyrosine; Ubiquitins | 1998 |
The ubiquitin-proteasome system and cellular proliferation and regulation in osteoblastic cells.
Topics: Acetylcysteine; Animals; Biopolymers; Cell Division; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Osteoblasts; Parathyroid Hormone; Peptide Fragments; Proteasome Endopeptidase Complex; Second Messenger Systems; Teriparatide; Tumor Cells, Cultured; Ubiquitins | 1998 |
Proparathyroid hormone-related protein is associated with the chaperone protein BiP and undergoes proteasome-mediated degradation.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Brefeldin A; Carrier Proteins; Cell Line; Cricetinae; Cricetulus; Cyclopentanes; Cysteine Endopeptidases; Cytoplasm; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Hydrolysis; Macrolides; Molecular Chaperones; Multienzyme Complexes; Parathyroid Hormone-Related Protein; Proteasome Endopeptidase Complex; Protein Binding; Protein Precursors; Proteins; Subcellular Fractions | 1998 |
Evidence for the participation of the proteasome and calpain in early phases of muscle cell differentiation.
Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Calpain; Carrier Proteins; Cell Differentiation; Cell Line; Creatine Kinase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Iron-Binding Proteins; Multienzyme Complexes; Muscles; Myogenin; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Transferrin-Binding Proteins | 1998 |
Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Membranes; Multienzyme Complexes; Proteasome Endopeptidase Complex | 1998 |
Calnexin association is not sufficient to protect T cell receptor alpha proteins from rapid degradation in CD4+CD8+ thymocytes.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; CD4 Antigens; CD8 Antigens; Cells, Cultured; Cysteine Proteinase Inhibitors; Diamide; Half-Life; Methionine; Mice; Mice, Inbred C57BL; Molecular Chaperones; Receptors, Antigen, T-Cell, alpha-beta; Spleen; Sulfur Radioisotopes; T-Lymphocyte Subsets; T-Lymphocytes; Tosylphenylalanyl Chloromethyl Ketone | 1998 |
Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Cell Line; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Heart Ventricles; Humans; I-kappa B Proteins; Multienzyme Complexes; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha | 1998 |
p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cerebral Cortex; COS Cells; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Half-Life; Humans; Kinetics; Mammals; Mice; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Polymerase Chain Reaction; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Purines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Roscovitine; Sequence Deletion; Transfection; Ubiquitins | 1998 |
Regulated Co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein.
Topics: Acetylcysteine; Animals; Apolipoprotein B-100; Apolipoproteins B; Benzoquinones; Carcinoma, Hepatocellular; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Liver Neoplasms; Models, Biological; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Processing, Post-Translational; Puromycin; Quinones; Recombinant Proteins; Rifabutin; Transfection; Tumor Cells, Cultured; Ubiquitins | 1998 |
Inhibitors of the proteasome block the myogenic differentiation of rat L6 myoblasts.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Induction; Enzyme Inhibitors; Membrane Fusion; Multienzyme Complexes; Muscle Proteins; Muscles; Myosin Heavy Chains; NF-kappa B; Nitric Oxide Synthase; omega-N-Methylarginine; Proteasome Endopeptidase Complex; Rats | 1998 |
DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells.
Topics: Acetylcysteine; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Cytarabine; Deferoxamine; DNA Damage; Etoposide; Gene Expression Regulation; Hydroxyurea; Polyribosomes; RNA, Messenger; Tumor Cells, Cultured; Ubiquitins | 1998 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Coumarins; Cysteine Endopeptidases; Fluorescence; Fungal Proteins; Histocompatibility Antigens Class I; Isocoumarins; Leupeptins; Molecular Sequence Data; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Substrate Specificity; Vertebrates | 1998 |
Proteasome inhibitors block development of Plasmodium spp.
Topics: Acetylcysteine; Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Humans; Hypoxanthine; Multienzyme Complexes; Plasmodium; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 1998 |
Proteasome-mediated degradation of apolipoprotein B targets both nascent peptides cotranslationally before translocation and full-length apolipoprotein B after translocation into the endoplasmic reticulum.
Topics: Acetylcysteine; Apolipoproteins B; Biological Transport; Cell Compartmentation; Cysteine Endopeptidases; Cytosol; Endoplasmic Reticulum; Glycosylation; Humans; Liver; Models, Biological; Multienzyme Complexes; Peptide Chain Elongation, Translational; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Tumor Cells, Cultured; Ubiquitins | 1998 |
The 20S proteasome of Streptomyces coelicolor.
Topics: Acetylcysteine; Amino Acid Sequence; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, Bacterial; Molecular Sequence Data; Multienzyme Complexes; Mycobacterium; Proteasome Endopeptidase Complex; Rhodococcus; Sequence Homology, Amino Acid; Streptomyces; Substrate Specificity | 1998 |
The pathway for processing leader-derived peptides that regulate the maturation and expression of Qa-1b.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Carrier Proteins; Cell Membrane; Cysteine Proteinase Inhibitors; Epitopes; Histocompatibility Antigens Class I; Humans; Mice; Molecular Sequence Data; Mutation; Protein Sorting Signals; T-Lymphocytes, Cytotoxic; Transfection; Tumor Cells, Cultured | 1998 |
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Immediate-Early Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Processing, Post-Translational; Receptors, Erythropoietin; Signal Transduction; src Homology Domains; STAT5 Transcription Factor; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Tyrosine; Ubiquitins | 1998 |
Proteolysis negatively regulates agonist-stimulated arachidonic acid metabolism.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Carcinogens; Cell Line; Endopeptidases; Epoprostenol; Leupeptins; Lyngbya Toxins; Phenylmethylsulfonyl Fluoride; Prostaglandin-Endoperoxide Synthases; Protease Inhibitors; Rats; Signal Transduction | 1998 |
The proteasome inhibitor lactacystin prevents the generation of an endoplasmic reticulum leader-derived T cell epitope.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens, Viral; Cysteine Endopeptidases; Depression, Chemical; Endoplasmic Reticulum; Enzyme Inhibitors; Glycoproteins; H-2 Antigens; Histocompatibility Antigen H-2D; Immunodominant Epitopes; Intercellular Signaling Peptides and Proteins; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Sorting Signals; Viral Proteins | 1998 |
Calpain involvement in calphostin C-induced apoptosis.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Multienzyme Complexes; Naphthalenes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; U937 Cells; Ubiquitins | 1998 |
Stabilization of mutant 46-kDa mannose 6-phosphate receptors by proteasomal inhibitor lactacystin.
Topics: Acetylcysteine; Animals; Base Sequence; Cell Line; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Primers; Endoplasmic Reticulum; Hydrolysis; Lysosomes; Multienzyme Complexes; Palmitic Acid; Proteasome Endopeptidase Complex; Receptor, IGF Type 2; Sequence Deletion | 1998 |
Generation of the vesicular stomatitis virus nucleoprotein cytotoxic T lymphocyte epitope requires proteasome-dependent and -independent proteolytic activities.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Viral; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Histocompatibility Antigens Class I; Mice; Molecular Sequence Data; Multienzyme Complexes; Nucleoproteins; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Vesicular stomatitis Indiana virus | 1998 |
Proteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts.
Topics: Acetylcysteine; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Hydrogen Peroxide; Multienzyme Complexes; Oxidation-Reduction; Oxidative Stress; Proteasome Endopeptidase Complex; Proteins | 1998 |
Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase Inhibitors; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; Female; Ionomycin; Ionophores; Mice; Mice, Inbred C57BL; Multienzyme Complexes; NF-kappa B; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Transcription Factor RelA; Transcription Factors; Transgenes; Up-Regulation | 1998 |
Dual roles of proteasome in the metabolism of presenilin 1.
Topics: Acetylcysteine; Alzheimer Disease; Amino Acid Sequence; Brain Chemistry; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glycoproteins; Humans; Isocoumarins; Kidney; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Mutation; Neuroblastoma; Peptide Fragments; Precipitin Tests; Presenilin-1; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Sulfones; Trypsin Inhibitors; Tumor Cells, Cultured | 1999 |
Proteolysis in human lens epithelium determined by a cell-permeable substrate.
Topics: Acetylcysteine; Calcium; Calpain; Cell Membrane Permeability; Cell Survival; Coumarins; Cysteine Endopeptidases; Enzyme Inhibitors; Epithelium; Humans; Ionomycin; L-Lactate Dehydrogenase; Lens, Crystalline; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Substrate Specificity; Thapsigargin | 1999 |
Inhibition of proteasome, apoptosis and sensitization to tumour necrosis factor alpha: do they always go together?
Topics: Acetylcysteine; Aldehydes; Animals; Apoptosis; Cysteine Proteinase Inhibitors; Humans; Leukemia L1210; Melanoma, Experimental; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
Cleavage of the calpain inhibitor, calpastatin, during apoptosis.
Topics: Acetylcysteine; Apoptosis; Calcium-Binding Proteins; Calpain; Caspase 3; Caspases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; fas Receptor; Flow Cytometry; Humans; Jurkat Cells; Pepstatins; Protease Inhibitors; Staurosporine; Tumor Necrosis Factor-alpha; U937 Cells | 1998 |
The involvement of proteasome in myogenic differentiation of murine myocytes and human rhabdomyosarcoma cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Cycle; Cell Differentiation; Cell Nucleus; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Humans; Mice; Microfilament Proteins; Multienzyme Complexes; Muscle Proteins; Muscles; MyoD Protein; Myosin Heavy Chains; Proteasome Endopeptidase Complex; Rhabdomyosarcoma; Serum Albumin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome.
Topics: Acetylcysteine; Animals; Arthritis; Boronic Acids; Cell Adhesion Molecules; Cytokines; Dipeptides; Endothelium, Vascular; Female; HeLa Cells; Humans; Hypersensitivity, Delayed; Jurkat Cells; Leupeptins; NF-kappa B; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Rats, Inbred Lew; T-Lymphocytes | 1999 |
Proteasome inhibitors MG132 and lactacystin hyperphosphorylate HSF1 and induce hsp70 and hsp27 expression.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Fibroblasts; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Phosphorylation; Receptors, Estrogen; Transcription Factors | 1999 |
Presecretory degradation of apolipoprotein [a] is mediated by the proteasome pathway.
Topics: Acetylcysteine; Animals; Apolipoproteins A; Calnexin; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fabaceae; Hepatocytes; Hexosaminidases; Leupeptins; Mannosidases; Molecular Chaperones; Multienzyme Complexes; Papio; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Transfection; Ubiquitin | 1999 |
A giant protease with potential to substitute for some functions of the proteasome.
Topics: Acetylcysteine; Alleles; Amino Acid Chloromethyl Ketones; Aminopeptidases; Animals; Cell Survival; Coumarins; Cysteine Endopeptidases; Cytosol; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Epitopes; Genes, MHC Class I; Hydrolysis; Mice; Molecular Weight; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Tumor Cells, Cultured | 1999 |
Total synthesis and biological activity of lactacystin, omuralide and analogs.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cattle; Cysteine Proteinase Inhibitors; Lactams; Lactones; Multienzyme Complexes; Structure-Activity Relationship | 1999 |
Proteasome-dependent degradation of the human estrogen receptor.
Topics: Acetylcysteine; Animals; Arabidopsis; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Escherichia coli; Estradiol; HeLa Cells; Humans; Kinetics; Leupeptins; Mammals; Multienzyme Complexes; Proteasome Endopeptidase Complex; Receptors, Estrogen; Receptors, Progesterone; Receptors, Thyroid Hormone; Recombinant Proteins; Substrate Specificity; Transfection; Ubiquitins | 1999 |
Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.
Topics: Acetylcysteine; Adult; Animals; Ataxin-3; Brain; Brain Chemistry; Cell Line; Cell Nucleus; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; HeLa Cells; Humans; Immunohistochemistry; Inclusion Bodies; Leukemia, Promyelocytic, Acute; Machado-Joseph Disease; Male; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Oncogene Proteins; PC12 Cells; Peptides; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Repressor Proteins | 1999 |
Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.
Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Cysteine Endopeptidases; Humans; Multienzyme Complexes; Neoplasm Proteins; Peptide Fragments; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1999 |
Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks.
Topics: Acetylcysteine; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Deoxyribonucleases, Type II Site-Specific; DNA Damage; DNA-Binding Proteins; Heat-Shock Response; Humans; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proteins; Serine; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Xeroderma Pigmentosum | 1999 |
Posttranslational regulation of the retinoblastoma gene family member p107 by calpain protease.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Bucladesine; Calpain; Cyclin B; Cyclin B1; Cysteine Proteinase Inhibitors; Dipeptides; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ketones; Leupeptins; Lovastatin; Nuclear Proteins; Protein Processing, Post-Translational; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Tumor Cells, Cultured | 1999 |
Effect of selective proteasome inhibitors on TNF-induced activation of primary and transformed endothelial cells.
Topics: Acetylcysteine; Adult; Cell Adhesion; Cell Line, Transformed; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; E-Selectin; Endothelium, Vascular; Gene Expression Regulation; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Kinetics; Monocytes; Multienzyme Complexes; Neutrophils; Proteasome Endopeptidase Complex; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1999 |
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia; Leupeptins; Molecular Weight; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Signal Transduction; Time Factors; Tumor Cells, Cultured; Ubiquitins | 1999 |
Inhibition of cytoplasmic antigen, glucose- 6-phosphate dehydrogenase, by VH-CH1, an intracellular Fd fragment antibody derived from a semisynthetic Fd fragment phage display library.
Topics: Acetylcysteine; Animals; Cell Line; Cricetinae; Cricetulus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Gene Expression Regulation, Enzymologic; Glucosephosphate Dehydrogenase; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Inovirus; Isopropyl Thiogalactoside; Kinetics; Leupeptins; Multienzyme Complexes; Peptide Library; Proteasome Endopeptidase Complex; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 1999 |
Discrimination between ubiquitin-dependent and ubiquitin-independent proteolytic pathways by the 26S proteasome subunit 5a.
Topics: Acetylcysteine; Enzyme Inhibitors; Humans; Kinetics; Muramidase; Ornithine Decarboxylase; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Binding; Protein Biosynthesis; Reticulocytes; RNA, Messenger; Ubiquitins | 1999 |
Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin.
Topics: Acetylcysteine; Aged; Apoptosis; Blotting, Western; Cysteine Proteinase Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase.
Topics: Acetylcysteine; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line; Cysteine Endopeptidases; Enzyme Inhibitors; Epitopes, T-Lymphocyte; Gene Deletion; Histocompatibility Antigens Class II; HIV Reverse Transcriptase; HIV-1; Humans; Interferon-gamma; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Viral Matrix Proteins | 1999 |
Inhibition of E6 induced degradation of p53 is not sufficient for stabilization of p53 protein in cervical tumour derived cell lines.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Carcinoma; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; Female; Fibrosarcoma; Humans; Leupeptins; Mitomycin; Oncogene Proteins, Viral; Papillomaviridae; Polymorphism, Genetic; Repressor Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 1999 |
Sarcomeric myosin heavy chain is degraded by the proteasome.
Topics: Acetylcysteine; Animals; Cardiomegaly; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Heart Ventricles; Multienzyme Complexes; Myosin Heavy Chains; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Sarcomeres | 1999 |
Differential inhibition of three peptidase activities of the proteasome in human lens epithelium by heat and oxidation.
Topics: Acetylcysteine; Cataract; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epithelium; Hot Temperature; HSP90 Heat-Shock Proteins; Humans; Hydrogen Peroxide; Lens, Crystalline; Multienzyme Complexes; Oxidants; Oxidation-Reduction; Peptide Hydrolases; Protease Inhibitors; Proteasome Endopeptidase Complex | 1999 |
Ubiquitin-proteasome system is involved in induction of LFA-1/ICAM-1-dependent adhesion of HL-60 cells.
Topics: Acetylcysteine; Adenosine Triphosphatases; Antibody Affinity; Cell Adhesion; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; HL-60 Cells; Humans; Intercellular Adhesion Molecule-1; Leupeptins; Lymphocyte Function-Associated Antigen-1; Monocytes; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tetradecanoylphorbol Acetate; Tretinoin; Ubiquitins | 1999 |
The length of polyglutamine tract, its level of expression, the rate of degradation, and the transglutaminase activity influence the formation of intracellular aggregates.
Topics: Acetylcysteine; Animals; COS Cells; Cystamine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Models, Biological; Peptides; Recombinant Fusion Proteins; Time Factors; Transglutaminases; Trinucleotide Repeat Expansion; Tumor Cells, Cultured; Ubiquitins | 1999 |
The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair.
Topics: Acetylcysteine; Adenosine Triphosphatases; Alkylation; Antibodies; Binding Sites; Cell Extracts; DNA Repair; DNA-Binding Proteins; Fungal Proteins; Kinetics; Mutation; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Deletion; Ultraviolet Rays | 1999 |
C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycopeptides; Humans; Leucine; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Pepstatins; Presenilin-1; Presenilin-2; Proteasome Endopeptidase Complex; Recombinant Proteins; Sulfones; Transfection | 1999 |
Suppression of oncogenic transformation by hypothemycin associated with accelerated cyclin D1 degradation through ubiquitin-proteasome pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Transformed; Cell Transformation, Neoplastic; Cyclin D1; Cysteine Endopeptidases; DNA, Complementary; Down-Regulation; G1 Phase; Mice; Mitosporic Fungi; Multienzyme Complexes; Proteasome Endopeptidase Complex; Repressor Proteins; Schizosaccharomyces; Ubiquitins; Zearalenone | 1999 |
Components of the bovine pituitary multicatalytic proteinase complex (proteasome) cleaving bonds after hydrophobic residues.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Cattle; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Hydrolysis; Insulin; Isocoumarins; Kinetics; Lactams; Molecular Sequence Data; Multienzyme Complexes; Pituitary Gland; Proteasome Endopeptidase Complex | 1999 |
Studies on degradative mechanisms mediating post-translational fragmentation of apolipoprotein B and the generation of the 70-kDa fragment.
Topics: Acetylcysteine; Apolipoproteins B; Carrier Proteins; Cell Line; Cysteine Endopeptidases; Dithiothreitol; Fluorenes; Humans; Hydrolysis; Isoindoles; Lactones; Multienzyme Complexes; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational | 1999 |
Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex.
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hepatitis B virus; Humans; Leupeptins; Multienzyme Complexes; Peptide Hydrolases; Proteasome Endopeptidase Complex; Substrate Specificity; Trans-Activators; Transcriptional Activation; Tumor Cells, Cultured; Ubiquitins; Viral Regulatory and Accessory Proteins | 1999 |
Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Deletion; Gene Expression Regulation, Neoplastic; Growth Inhibitors; Hemagglutinins; Humans; Leupeptins; Mice; Models, Genetic; Multienzyme Complexes; Mutagenesis; Osteosarcoma; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitins | 1999 |
The degradation of nascent fibrinogen chains is mediated by the ubiquitin proteasome pathway.
Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Immunosorbent Techniques; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Transfection; Ubiquitins | 1999 |
Direct proteasome inhibition by clasto-lactacystin beta-lactone permits the detection of ubiquitinated p21(waf1) in ML-1 cells.
Topics: Acetylcysteine; Antibodies; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deferoxamine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Lactones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Ubiquitins | 1999 |
Cell-cell dissociation upon epithelial cell scattering requires a step mediated by the proteasome.
Topics: Acetylcysteine; Animals; Cadherins; Cell Line; Cell Movement; Chemotaxis; Connexins; Cysteine Endopeptidases; Dogs; Epithelial Cells; Hepatocyte Growth Factor; Immunohistochemistry; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oncogene Protein pp60(v-src); Phosphoproteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Tight Junctions; Zonula Occludens-1 Protein | 1999 |
Phosphorylation and proteasome-dependent degradation of Bcl-2 in mitotic-arrested cells after microtubule damage.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Leupeptins; Microtubules; Mitosis; Multienzyme Complexes; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
A role for the proteasome in the light response of the timeless clock protein.
Topics: Acetylcysteine; Animals; Biological Clocks; Cells, Cultured; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Darkness; Drosophila; Drosophila Proteins; Feedback; Insect Proteins; Leucine; Leupeptins; Light; Multienzyme Complexes; Neurons; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Proteasome Endopeptidase Complex; Ubiquitins | 1999 |
Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates.
Topics: Acetylcysteine; Aspartic Acid; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Humans; Marine Toxins; Oxocins; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Staurosporine; Substrate Specificity | 1999 |
Proteasome-dependent cyst formation and stage-specific ubiquitin mRNA accumulation in Entamoeba invadens.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Gel, Two-Dimensional; Entamoeba; Gene Expression Regulation, Developmental; Genes, Protozoan; Microscopy, Electron; Multienzyme Complexes; Proteasome Endopeptidase Complex; RNA, Messenger; RNA, Protozoan; Ubiquitins | 1999 |
Calpain inhibitor causes accumulation of ubiquitinated P-glycoprotein at the cell surface: possible role of calpain in P-glycoprotein turnover.
Topics: Acetylcysteine; Ammonium Chloride; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Brefeldin A; Calpain; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; Doxorubicin; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Humans; K562 Cells; Leucine; Leupeptins; Membrane Proteins; Protein Synthesis Inhibitors; Time Factors; Ubiquitins | 1999 |
Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells.
Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cell Division; Cell Survival; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glioma; Glycoproteins; Humans; Kinetics; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Serine Proteinase Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy.
Topics: Acetylcysteine; Acquired Immunodeficiency Syndrome; Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance, Multiple; Glycosylation; Humans; Leupeptins; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Precursors; Protein Processing, Post-Translational | 1999 |
NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species.
Topics: Acetylcysteine; Antioxidants; Cell Line; Chromans; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP2E1; Electron Spin Resonance Spectroscopy; Electron Transport; Enzyme Stability; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Multienzyme Complexes; NADP; Oxidative Stress; Proteasome Endopeptidase Complex; Reactive Oxygen Species | 1999 |
Expression, regulation, and function of B cell-expressed CD154 in germinal centers.
Topics: Acetylcysteine; B-Lymphocyte Subsets; CD40 Antigens; CD40 Ligand; Cell Communication; Cell Count; Cell Separation; Cells, Cultured; Cyclosporine; Flavonoids; Germinal Center; Humans; Immunologic Memory; Immunophenotyping; Ligands; Lymphocyte Activation; Membrane Glycoproteins; Palatine Tonsil; Protein Synthesis Inhibitors; Receptors, Antigen, B-Cell; Up-Regulation | 1999 |
The Leishmania mexicana proteasome.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leishmania mexicana; Molecular Weight; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Substrate Specificity | 1999 |
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
Topics: Acetylcysteine; Administration, Topical; Calcitriol; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Gene Expression Regulation; Humans; Keratinocytes; Leucine; Leupeptins; Multienzyme Complexes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Receptors, Calcitriol; Skin; Steroid Hydroxylases; Ubiquitins; Vitamin D3 24-Hydroxylase | 1999 |
Cloning and partial characterization of the proteasome S4 ATPase from Plasmodium falciparum.
Topics: Acetylcysteine; Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Cysteine Proteinase Inhibitors; DNA, Complementary; DNA, Protozoan; Molecular Sequence Data; Open Reading Frames; Plasmodium falciparum; Polymerase Chain Reaction; Precipitin Tests; RNA, Protozoan; Sequence Alignment; Sequence Homology, Amino Acid | 1999 |
Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Hot Temperature; HSP70 Heat-Shock Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; Transcription Factors | 1999 |
Proteolytic degradation of the retinoblastoma family protein p107: A putative cooperative role of calpain and proteasome.
Topics: Acetylcysteine; Antineoplastic Agents; Blotting, Western; Calcium-Binding Proteins; Calpain; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Humans; Lovastatin; Male; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Sarcoma, Ewing; Transfection; Tumor Cells, Cultured; Ubiquitins | 1999 |
cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Breast Neoplasms; Carrier Proteins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Phosphoproteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Signal Transduction; Tumor Cells, Cultured; Ubiquitin-Protein Ligases; Ubiquitins | 1999 |
Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Carcinogenicity Tests; Cell Differentiation; Cell Division; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, Dominant; Genes, Tumor Suppressor; Humans; Leupeptins; Lung Neoplasms; Mice; Mice, Nude; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tumor Cells, Cultured; Ultraviolet Rays | 1999 |
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; B-Lymphocytes; bcl-X Protein; Canavanine; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Synergism; Enzyme Activation; Hematopoietic Stem Cells; HSP70 Heat-Shock Proteins; Interleukin-3; Leupeptins; Mice; Multienzyme Complexes; Oligonucleotides, Antisense; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2 | 1999 |
Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol.
Topics: Acetylcysteine; Animals; Antibodies; Biological Transport; Calcium; Chlorocebus aethiops; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Drug Synergism; Endoplasmic Reticulum; Glycosylation; Humans; Hydrogen-Ion Concentration; Ionophores; Membrane Proteins; Monensin; Multienzyme Complexes; Mutation; Precipitin Tests; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Ricin; SEC Translocation Channels; Sulfates; Tumor Cells, Cultured; Vero Cells | 1999 |
Regulation of heme oxygenase-1 expression by dopamine in cultured C6 glioma and primary astrocytes.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Ascorbic Acid; Astrocytes; Catechol O-Methyltransferase Inhibitors; Catechols; Cell Line; Cycloheximide; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Glioma; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Membrane Proteins; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; RNA, Messenger; Selegiline; Time Factors; Tumor Cells, Cultured | 1999 |
Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Chloroquine; Clathrin; Colforsin; Cycloheximide; Dogs; Dopamine; Dopamine Plasma Membrane Transport Proteins; Endocytosis; Enzyme Activation; Humans; Kinetics; Lysosomes; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Phorbols; Protein Kinase C; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Transfection | 1999 |
Delayed and sustained activation of p42/p44 mitogen-activated protein kinase induced by proteasome inhibitors through p21(ras) in PC12 cells.
Topics: Acetylcysteine; Animals; Autocrine Communication; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Activation; ets-Domain Protein Elk-1; Leupeptins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Neurites; PC12 Cells; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Rats; Time Factors; Transcription Factors | 2000 |
Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Rats; Rats, Wistar; Ubiquitins | 2000 |
Endocytosis and degradation of the growth hormone receptor are proteasome-dependent.
Topics: Acetylcysteine; Animals; Blotting, Western; CHO Cells; Cricetinae; Cysteine Proteinase Inhibitors; Endocytosis; Growth Hormone; Ligands; Lysine; Mutagenesis; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Receptors, Somatotropin; Time Factors; Transferrin | 2000 |
Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes.
Topics: Acetylcysteine; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP Binding Cassette Transporter, Subfamily B, Member 3; ATP-Binding Cassette Transporters; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Gene Products, nef; Histocompatibility Antigens Class I; HIV-1; HLA-A2 Antigen; HLA-B7 Antigen; Humans; Ligands; Multienzyme Complexes; nef Gene Products, Human Immunodeficiency Virus; Peptide Fragments; Peptides; Proteasome Endopeptidase Complex; Research Design; T-Lymphocytes, Cytotoxic | 2000 |
Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity.
Topics: Acetylcysteine; Animals; Biological Transport; Carrier Proteins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Immunoglobulin Light Chains; Mice; Molecular Chaperones; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2000 |
Bryostatin 1 induces ubiquitination and proteasome degradation of Bcl-2 in the human acute lymphoblastic leukemia cell line, Reh.
Topics: Acetylcysteine; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Bryostatins; Cell Extracts; Cysteine Endopeptidases; Humans; Lactones; Macrolides; Multienzyme Complexes; Precipitin Tests; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Ubiquitins | 2000 |
A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Binding, Competitive; Cell Compartmentation; CHO Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Endoplasmic Reticulum; Humans; Hydrolysis; Intracellular Fluid; Leupeptins; Multienzyme Complexes; Neurons; Peptide Fragments; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Tumor Cells, Cultured | 2000 |
The proteasome controls the expression of a proliferation-associated nuclear antigen Ki-67.
Topics: Acetylcysteine; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Cysteine Endopeptidases; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Ki-67 Antigen; Microscopy, Fluorescence; Microtubule-Associated Proteins; Multienzyme Complexes; Proteasome Endopeptidase Complex; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Leupeptins; Milk Proteins; Multienzyme Complexes; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Structure, Secondary; STAT5 Transcription Factor; Trans-Activators; Transcriptional Activation; Tyrosine | 2000 |
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins | 2000 |
Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system.
Topics: Acetylcysteine; Animals; Brain; Cell Differentiation; Cell Division; Cell Line; Cell Transplantation; Cysteine Endopeptidases; Fluorescent Antibody Technique; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Mice; Mice, Nude; Multienzyme Complexes; Muscle, Smooth; Nerve Tissue Proteins; Phenanthrolines; Proteasome Endopeptidase Complex; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Transformation, Genetic; Ubiquitins | 2000 |
Ubiquitylation and destruction of endogenous c-mycS by the proteasome: are myc boxes dispensable?
Topics: Acetylcysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genes, myc; Half-Life; HL-60 Cells; Humans; Kinetics; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; Recombinant Proteins; Transfection; Ubiquitins | 2000 |
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
Topics: Acetylcysteine; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flow Cytometry; Glycosylation; HeLa Cells; Humans; Membrane Glycoproteins; Multienzyme Complexes; Mutation; Photoaffinity Labels; Prazosin; Proteasome Endopeptidase Complex; Transfection; Trypsin; Vaccinia virus | 2000 |
ATP-dependent dissociation of non-disulfide-linked aggregates of coagulation factor VIII is a rate-limiting step for secretion.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Carrier Proteins; CHO Cells; Cricetinae; Disulfides; Endoplasmic Reticulum Chaperone BiP; Factor VIII; Heat-Shock Proteins; Kinetics; Molecular Chaperones; Precipitin Tests; Protein Binding; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Time Factors; Transfection; von Willebrand Factor | 2000 |
Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Caspases; Cell Division; Cell Survival; Cells, Cultured; Cerebellum; Cysteine Endopeptidases; Enzyme Activation; Gene Expression; Multienzyme Complexes; Neurons; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ubiquitins | 2000 |
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.
Topics: Acetylcysteine; Animals; Blotting, Western; Carrier Proteins; Cell Death; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Exons; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Huntington Disease; Immunohistochemistry; Multienzyme Complexes; Peptides; Plasmids; Proteasome Endopeptidase Complex; Rats; Temperature; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
Accumulation and degradation in the endoplasmic reticulum of a truncated ER-60 devoid of C-terminal amino acid residues.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Carrier Proteins; Cell Membrane; COS Cells; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochalasin B; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Half-Life; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Membrane Proteins; Molecular Chaperones; Protein Disulfide-Isomerases; Recombinant Proteins; Ribonucleoproteins | 2000 |
Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.
Topics: Acetylcysteine; Azetidines; Cells, Cultured; DNA-Binding Proteins; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione; Liver; Neoplasm Proteins; NF-E2-Related Factor 2; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Structure, Quaternary; Response Elements; Trans-Activators | 2000 |
p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p27; Cysteine Endopeptidases; Humans; Leupeptins; Microtubule-Associated Proteins; Mouth Mucosa; Mouth Neoplasms; Multienzyme Complexes; Oligonucleotides, Antisense; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Precursors; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
Degradation of human thyroperoxidase in the endoplasmic reticulum involves two different pathways depending on the folding state of the protein.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Antibodies, Monoclonal; Chloroquine; CHO Cells; Cricetinae; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Emetine; Endoplasmic Reticulum; Humans; Multienzyme Complexes; Peroxidase; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Folding; Thyroid Gland | 2000 |
The proteasome is involved in the first metaphase-to-anaphase transition of meiosis in rat oocytes.
Topics: Acetylcysteine; Anaphase; Animals; Cyclin B; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Leupeptins; Meiosis; Metaphase; Multienzyme Complexes; Oligopeptides; Oocytes; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Spindle Apparatus | 2000 |
Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress.
Topics: Acetylcysteine; Adenosine Triphosphate; Cell Survival; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Hydrogen Peroxide; K562 Cells; Multienzyme Complexes; Oligopeptides; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptide Hydrolases; Proteasome Endopeptidase Complex; Time Factors | 2000 |
Degradation of DNA topoisomerase I by a novel trypsin-like serine protease in proliferating human T lymphocytes.
Topics: Acetylcysteine; Apyrase; Cell Division; Cell Line; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytosol; DNA Topoisomerases, Type I; Humans; Immunoblotting; Jurkat Cells; Magnesium; Microfilament Proteins; Muscle Proteins; Phytohemagglutinins; Protein Biosynthesis; Recombinant Fusion Proteins; Serine Endopeptidases; T-Lymphocytes; Temperature; Trypsin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Oligosaccharide trimming plays a role in the endoplasmic reticulum-associated degradation of tyrosinase.
Topics: 1-Deoxynojirimycin; Acetylcysteine; Alkaloids; Animals; Antigens; Calcium-Binding Proteins; Calnexin; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Enzyme Inhibitors; Glucosidases; Humans; Indolizines; Mannosidases; Models, Biological; Monophenol Monooxygenase; Precipitin Tests; Time Factors | 2000 |
The major substrates for TAP in vivo are derived from newly synthesized proteins.
Topics: Acetylcysteine; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cysteine Proteinase Inhibitors; Green Fluorescent Proteins; HLA-A2 Antigen; Humans; Luminescent Proteins; Protein Conformation; Proteins; Transfection; Tumor Cells, Cultured; Viral Proteins | 2000 |
Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Binding Sites; Calcium; Calmodulin; Chickens; HeLa Cells; Humans; Microinjections; Muscle, Skeletal; Oocytes; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Conformation; Protein Denaturation; Rabbits; Ubiquitins; Xenopus | 2000 |
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; T-Lymphocytes; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2000 |
Proteasome inhibition measurements: clinical application.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Cysteine Endopeptidases; Humans; In Vitro Techniques; Kinetics; Male; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence | 2000 |
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epitopes, T-Lymphocyte; Hepatitis B e Antigens; Histocompatibility Antigens Class I; HIV Envelope Protein gp160; HIV-1; Humans; Hydrolysis; Leupeptins; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; T-Lymphocytes, Cytotoxic | 2000 |
Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.
Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Northern; Cell Cycle; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Glucose; Humans; Hypoxia; Immunoblotting; Isoenzymes; Methotrexate; Mice; Mice, Nude; Multienzyme Complexes; Neoplasm Transplantation; Nucleic Acid Synthesis Inhibitors; Proteasome Endopeptidase Complex; Time Factors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Vincristine | 2000 |
Proteolytic activity in intact sheets of polarized epithelial cells as determined by a cell-permeable fluorogenic substrate.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium; Calpain; Cell Polarity; Cells, Cultured; Colforsin; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epithelial Cells; Fluorescence; L-Lactate Dehydrogenase; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Swine; Thyroid Gland | 2000 |
Inhibitory and stimulatory effects of lactacystin on expression of nitric oxide synthase type 2 in brain glial cells. The role of Ikappa B-beta.
Topics: Acetylcysteine; Animals; Astrocytoma; Brain; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glioma; Humans; I-kappa B Proteins; Inflammation; Interferons; Interleukin-1; Kinetics; Neuroglia; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Rats; Recombinant Proteins; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2000 |
Reversal of regioselection in the sharpless asymmetric aminohydroxylation of aryl ester substrates.
Topics: Acetylcysteine; Amino Acids; Anti-Bacterial Agents; Lactams; Ligands; Models, Molecular; Molecular Conformation; Stereoisomerism | 1999 |
The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Viral; Apoptosis; Cell Division; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Immunologic; Down-Regulation; Glycoproteins; Humans; Hybridomas; Hydrolysis; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Multienzyme Complexes; Nucleoproteins; Oligopeptides; Peptide Fragments; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Ubiquitins; Up-Regulation; Viral Proteins | 2000 |
Role of p53 in cell cycle regulation and apoptosis following exposure to proteasome inhibitors.
Topics: Acetylcysteine; Apoptosis; Cell Nucleus; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; G1 Phase; G2 Phase; Humans; Interphase; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; Skin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.
Topics: 3T3 Cells; Acetylcysteine; Adenoviridae; Adipocytes; Animals; Cell Line; Cysteine Endopeptidases; Deoxyglucose; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression; Humans; Insulin; Insulin Receptor Substrate Proteins; Kidney; Mice; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; Sirolimus; Transfection | 2000 |
Separation of cathepsin A-like enzyme and the proteasome: evidence that lactacystin/beta-lactone is not a specific inhibitor of the proteasome.
Topics: Acetylcysteine; Animals; Blood Platelets; Cathepsin A; Cell Line, Tumor; Chromatography, Affinity; Concanavalin A; Cysteine Proteinase Inhibitors; Heparin; Humans; Mice; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2000 |
Decreased levels of proteasome activity and proteasome expression in aging spinal cord.
Topics: Acetylcysteine; Aging; Aldehydes; Amino Acid Chloromethyl Ketones; Animals; Cell Death; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glutathione; Iron; Lipid Peroxidation; Lysosomes; Mice; Motor Neurons; Multienzyme Complexes; Neuroblastoma; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Reactive Oxygen Species; Spinal Cord; Tumor Cells, Cultured | 2000 |
Naturally processed and concealed HLA-A2.1-restricted epitopes from tumor-associated antigen tyrosinase-related protein-2.
Topics: Acetylcysteine; Antigens, Neoplasm; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Coculture Techniques; Cysteine Proteinase Inhibitors; DNA Mutational Analysis; Enzyme-Linked Immunosorbent Assay; Epitopes; HIV Protease Inhibitors; HLA-A2 Antigen; Humans; Intramolecular Oxidoreductases; Leukocytes, Mononuclear; Melanoma; Peptides; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 2000 |
Differential susceptibility of normal and PARP knock-out mouse fibroblasts to proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cell Line; Cell Nucleus; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Fibroblasts; Fluorescent Dyes; Humans; Immunoblotting; Indoles; Leupeptins; Mice; Mice, Knockout; Microscopy, Fluorescence; Multienzyme Complexes; Oligopeptides; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Proteins; Time Factors; Tumor Suppressor Protein p53 | 2000 |
Lactacystin activates FLICE (caspase 8) protease and induces apoptosis in Fas-resistant adult T-cell leukemia cell lines.
Topics: Acetylcysteine; Adult; Anti-Bacterial Agents; Antigens, Surface; Apoptosis; Caspase 8; Caspase 9; Caspases; Cysteine Proteinase Inhibitors; Drug Resistance; Enzyme Activation; fas Receptor; Humans; Lactams; Leukemia, T-Cell; Sensitivity and Specificity; Tumor Cells, Cultured | 2000 |
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Caspase 3; Caspase 7; Caspase Inhibitors; Caspases; Cell Death; Crk-Associated Substrate Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Mitosis; Multienzyme Complexes; Mutation; Oligopeptides; Peptide Fragments; Phosphoproteins; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Isoforms; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Signal Transduction; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
The long signal peptide isoform and its alternative processing direct the intracellular trafficking of interleukin-15.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Biological Assay; Biological Transport; Cell Compartmentation; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylation; Hexosaminidases; Interleukin-15; Molecular Sequence Data; Protein Isoforms; Protein Precursors; Protein Processing, Post-Translational; Protein Sorting Signals | 2000 |
Deregulation of the ubiquitin system and p53 proteolysis modify the apoptotic response in B-CLL lymphocytes.
Topics: Acetylcysteine; Adenosine Triphosphatases; Apoptosis; bcl-2-Associated X Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; fas Receptor; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Multienzyme Complexes; Neoplasm Proteins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Reference Values; Tumor Suppressor Protein p53; Ubiquitins | 2000 |
Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function.
Topics: Acetylcysteine; Animals; Cattle; Cell Line; Cysteine Proteinase Inhibitors; DNA; DNA Adducts; DNA Damage; DNA Repair; Fibroblasts; Formaldehyde; Glutathione; Half-Life; Histones; Humans; Hydrolysis; Kidney; Kinetics; Lung; Lymphocytes; Male; Peptide Hydrolases; Serum Albumin, Bovine; Xeroderma Pigmentosum | 2000 |
Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition.
Topics: Acetylcysteine; Acrylates; Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Calpain; Cathepsins; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Drug Synergism; Genes, p53; Humans; Jurkat Cells; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Neoplasms; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fetus; Multienzyme Complexes; Neurons; Neurotoxins; Peptide Fragments; Proteasome Endopeptidase Complex; Ubiquitins | 2000 |
Caspase and proteasome activity during staurosporin-induced apoptosis in lens epithelial cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Benzimidazoles; Caspase Inhibitors; Caspases; Cattle; Cells, Cultured; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Fluorescent Dyes; In Situ Nick-End Labeling; Lens, Crystalline; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Staurosporine; Time Factors | 2000 |
Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1.
Topics: Acetylation; Acetylcysteine; Animals; Anti-Bacterial Agents; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chickens; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeleton; Down-Regulation; Enzyme Inhibitors; Female; G1 Phase; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoblotting; Keratins; Leupeptins; Multienzyme Complexes; Peptides; Phosphorylation; Proteasome Endopeptidase Complex; Quinidine; Retinoblastoma Protein; Time Factors; Tumor Cells, Cultured | 2000 |
F9 embryonal carcinoma cells fail to stop at G1/S boundary of the cell cycle after gamma-irradiation due to p21WAF1/CIP1 degradation.
Topics: Acetylcysteine; Animals; Apoptosis; Carcinoma, Embryonal; CDC2-CDC28 Kinases; Cell Cycle; Cyclin B; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; G1 Phase; Gamma Rays; Mice; Multienzyme Complexes; Nocodazole; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; S Phase; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28.
Topics: Acetylcysteine; Animals; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Autoantigens; Blotting, Western; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class I; Interferon-gamma; Leukemia Virus, Murine; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Proteins; Rats; Sulfones; T-Lymphocytes, Cytotoxic; Tetracycline | 2000 |
The B subunit of Shiga toxin fused to a tumor antigen elicits CTL and targets dendritic cells to allow MHC class I-restricted presentation of peptides derived from exogenous antigens.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens, Neoplasm; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Bacterial Toxins; Brefeldin A; Cytotoxicity, Immunologic; Dendritic Cells; Female; Histocompatibility Antigens Class I; Injections, Intraperitoneal; Intracellular Fluid; Leukemia L1210; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Ovalbumin; Peptides; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Sarcoma, Experimental; Shiga Toxins; Signal Transduction; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 2000 |
Activation-dependent degradation of protein kinase C eta.
Topics: Acetylcysteine; Animals; Cell Fractionation; Cell Line; Chick Embryo; Cricetinae; Cysteine Endopeptidases; Detergents; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Humans; Isoenzymes; Kidney; Leupeptins; Membrane Proteins; Mesocricetus; Mice; Multienzyme Complexes; Mutagenesis, Site-Directed; Proteasome Endopeptidase Complex; Protein Conformation; Protein Kinase C; Protein Kinase C-theta; Rats; Recombinant Fusion Proteins; Sindbis Virus; Tumor Cells, Cultured; Ubiquitins | 2000 |
Tripeptidyl peptidase II promotes maturation of caspase-1 in Shigella flexneri-induced macrophage apoptosis.
Topics: Acetylcysteine; Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Aminopeptidases; Animals; Apoptosis; Caspase 1; Cell Line; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dysentery, Bacillary; Gentamicins; Humans; Macrophages; Mice; Phagocytosis; Phagosomes; Serine Endopeptidases; Serine Proteinase Inhibitors; Shigella flexneri; Staurosporine | 2000 |
Proteasome inhibitors block the entry of liposome-encapsulated antigens into the classical MHC class I pathway.
Topics: Acetylcysteine; Animals; Bone Marrow Cells; Conalbumin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Golgi Apparatus; Histocompatibility Antigens Class I; Leupeptins; Liposomes; Macrophages; Mice; Models, Biological; Multienzyme Complexes; Peptides; Phagocytosis; Proteasome Endopeptidase Complex; Spleen; T-Lymphocytes, Cytotoxic | 2000 |
Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Calpain; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neurites; Neurofilament Proteins; PC12 Cells; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-jun; Rats; Ubiquitins | 2000 |
Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cells, Cultured; Chromatin; Cisplatin; Cysteine Endopeptidases; Cytosol; DNA; DNA Adducts; DNA Repair; DNA-Binding Proteins; Drug Interactions; Endonucleases; Enzyme Inhibitors; Female; Histones; Humans; Leucine; Multienzyme Complexes; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteins; RNA, Messenger; Ubiquitins | 2000 |
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
Topics: Acetylcysteine; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Humans; Melanoma; Oligonucleotides, Antisense; Receptor, IGF Type 1; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
The proteasome regulates receptor-mediated endocytosis of interleukin-2.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Endocytosis; Interleukin-2; Leupeptins; Lysosomes; Macromolecular Substances; Mice; Mice, Inbred C57BL; Milk Proteins; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex; Protein Subunits; Receptors, Interleukin-2; Spleen; STAT5 Transcription Factor; T-Lymphocytes; Trans-Activators | 2001 |
Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland.
Topics: Acetylcysteine; Animals; Arylamine N-Acetyltransferase; Bucladesine; Cattle; Cells, Cultured; Colforsin; Cyclic AMP; Cysteine Endopeptidases; Female; Male; Multienzyme Complexes; Neurons; Norepinephrine; Peptide Hydrolases; Pineal Gland; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Puromycin; RNA, Messenger; Signal Transduction; Stimulation, Chemical | 2000 |
Subcellular localization of presenilins during mouse preimplantation development.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; Cytoplasm; DNA, Antisense; Embryo, Mammalian; Embryonic Development; Female; Humans; Immunohistochemistry; Membrane Proteins; Mice; Mice, Inbred ICR; Microtubules; Mutation; Pregnancy; Presenilin-1; Presenilin-2; S Phase | 2000 |
c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB: role of thioredoxin in NF-kappaB activation.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Bacterial Proteins; Cell Line; Cell Nucleus; Endothelium, Vascular; Escherichia coli; Genes, Reporter; Humans; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Oxidation-Reduction; Protein Kinase C; Protein Serine-Threonine Kinases; Thioredoxins | 2001 |
Proteasome inhibitors induced caspase-dependent apoptosis and accumulation of p21WAF1/Cip1 in human immature leukemic cells.
Topics: Acetylcysteine; Acute Disease; Adult; Antigens, CD34; Apoptosis; Caspase 3; Caspases; Cell Culture Techniques; Cell Cycle; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Hematopoietic Stem Cells; Humans; K562 Cells; Leukemia; Leupeptins; Mitosis; Multienzyme Complexes; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; U937 Cells | 2000 |
Retinoic acid reduces p11 protein levels in bronchial epithelial cells by a posttranslational mechanism.
Topics: Acetylcysteine; Annexin A2; Antineoplastic Agents; Arachidonic Acid; Bronchi; Calcimycin; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Epithelial Cells; Gene Expression; Humans; Ionophores; Multienzyme Complexes; Peptides; Phospholipases A; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Respiratory Mucosa; RNA, Messenger; S100 Proteins; Transfection; Tretinoin; Ubiquitins | 2000 |
Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Apoptosis; Caspases; Cell Survival; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Glioma; Humans; Lactams; Leupeptins; Membrane Glycoproteins; Mice; Mitochondria; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-bcl-2; Transgenes; Tumor Cells, Cultured | 2000 |
Proteasome inhibitors block intracellular growth and replication of Toxoplasma gondii.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; DNA, Protozoan; Endoplasmic Reticulum; Humans; Leupeptins; Microscopy, Electron; Multienzyme Complexes; Proteasome Endopeptidase Complex; Toxoplasma; Toxoplasmosis; Vacuoles | 2000 |
Ubiquitin is part of the retrovirus budding machinery.
Topics: Acetylcysteine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Membrane; Cysteine Endopeptidases; Endocytosis; Gene Products, gag; Leupeptins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Quail; Recombinant Fusion Proteins; Ubiquitins; Virus Replication | 2000 |
Proteasome-dependent degradation of cytosolic chaperonin CCT.
Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Cell Division; Chaperonin Containing TCP-1; Chaperonins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Enzyme Stability; Female; Kinetics; Ligases; Mammary Neoplasms, Experimental; Mice; Multienzyme Complexes; Multiple Myeloma; Protease Inhibitors; Proteasome Endopeptidase Complex; Temperature; Thermodynamics; Tumor Cells, Cultured; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases | 2000 |
A combination of lactacystin and 12-O-tetradecanoylphorbol-13-acetate enhances the release of arachidonic acid from cells in cultures: release is reduced in confluent and serum deprived cells.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Cattle; Cell Division; Cells, Cultured; Contact Inhibition; Culture Media; Culture Media, Serum-Free; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dexamethasone; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Gliotoxin; Group IV Phospholipases A2; Hepatocytes; Immunosuppressive Agents; Multienzyme Complexes; Muscle, Smooth, Vascular; Neuroglia; Organophosphonates; Phospholipases A; Phospholipases A2; Proteasome Endopeptidase Complex; Pulmonary Artery; Rats; Sodium Salicylate; Tetradecanoylphorbol Acetate | 2000 |
Lactacystin stimulates arachidonic acid metabolism in rat liver cells: effects of cell density on arachidonic acid release, PGI2 production and cyclooxygenase activity.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Cell Count; Cells, Cultured; Contact Inhibition; Culture Media, Serum-Free; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dactinomycin; Epoprostenol; Hepatocytes; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Rats; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 2000 |
Proteasomal function is impaired in substantia nigra in Parkinson's disease.
Topics: Acetylcysteine; Aged; Cysteine Endopeptidases; Dihydroxyphenylalanine; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Hydrolysis; Levodopa; Lewy Bodies; Male; Multienzyme Complexes; Parkinson Disease; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Substantia Nigra; Ubiquitins | 2001 |
Inhibition of proteasome activity by the TED4 protein in extracellular space: a novel mechanism for protection of living cells from injury caused by dying cells.
Topics: Acetylcysteine; Asteraceae; Cell Death; Cells, Cultured; Cysteine Endopeptidases; Endopeptidases; Extracellular Space; Glutathione Transferase; Hydrolases; Hydrolysis; Immunoblotting; Multienzyme Complexes; Peptide Hydrolases; Plant Proteins; Plant Shoots; Protease Inhibitors; Proteasome Endopeptidase Complex; Recombinant Proteins; Tetrahydrofolate Dehydrogenase | 2001 |
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Cysteine Proteinase Inhibitors; Databases as Topic; DNA-Binding Proteins; Humans; Ligases; Molecular Sequence Data; Oocytes; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Smad Proteins; Smad1 Protein; Smad2 Protein; Substrate Specificity; Trans-Activators; Ubiquitin-Protein Ligases; Xenopus laevis; Xenopus Proteins | 2001 |
Oxidative stress inhibits the mitochondrial import of preproteins and leads to their degradation.
Topics: Acetylcysteine; Animals; Blotting, Western; CHO Cells; COS Cells; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidase K; Green Fluorescent Proteins; HeLa Cells; Herbicides; Humans; Luminescent Proteins; Membrane Potentials; Mitochondria, Liver; Multienzyme Complexes; Ornithine Carbamoyltransferase; Oxidation-Reduction; Oxidative Stress; Oxygen; Paraquat; Proteasome Endopeptidase Complex; Protein Precursors; Protein Transport; Rats; Recombinant Fusion Proteins; Transfection | 2001 |
The ubiquitin-proteasome pathway plays an essential role in proteolysis during Trypanosoma cruzi remodeling.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane Permeability; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Flagella; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Macaca mulatta; Multienzyme Complexes; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protozoan Proteins; Trypanosoma cruzi; Ubiquitins | 2001 |
Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells.
Topics: Acetylcysteine; Apolipoproteins B; Cell Line; Cysteine Endopeptidases; Humans; Hydrolysis; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tunicamycin; Ubiquitins | 2001 |
Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Electron Transport; Enzyme Activation; Humans; Intracellular Membranes; Jurkat Cells; Leukemia, B-Cell; Leukemia, T-Cell; Membrane Potentials; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Multienzyme Complexes; Peptide Hydrolases; Permeability; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Tumor Cells, Cultured | 2001 |
MHC class II presentation of endogenous tumor antigen by cellular vaccines depends on the endocytic pathway but not H2-M.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigen-Presenting Cells; Antigens, Neoplasm; Antimalarials; Brefeldin A; CD4-Positive T-Lymphocytes; Chloroquine; Coculture Techniques; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Endocytosis; Endoplasmic Reticulum; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Genes, MHC Class II; Humans; Hybridomas; Leupeptins; Major Histocompatibility Complex; Mice; Muramidase; Plasmids; Primaquine; Protein Synthesis Inhibitors; Protein Transport; Ribonucleases; Transfection; Tumor Cells, Cultured | 2000 |
A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates.
Topics: Acetylcysteine; Adenosine Triphosphatases; Carrier Proteins; Cation Transport Proteins; Cell Line; Copper-Transporting ATPases; Cysteine Endopeptidases; Cytoskeleton; Fluorescent Antibody Technique; Humans; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; Tissue Distribution | 2001 |
Proteasome activity is required for T lymphocyte aggregation after mitogen activation.
Topics: Acetylcysteine; Animals; Blotting, Northern; Cell Adhesion; Cell Aggregation; Cell Communication; Cell Division; Cysteine Endopeptidases; Down-Regulation; Flow Cytometry; Humans; Hyaluronan Receptors; Intercellular Adhesion Molecule-1; L-Selectin; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Processing, Post-Translational; Receptors, Interleukin-2; RNA, Messenger; Spleen; T-Lymphocytes | 2001 |
BCR-ABL down-regulates the DNA repair protein DNA-PKcs.
Topics: Acetylcysteine; Animals; Apoptosis; Blast Crisis; Child; Cysteine Endopeptidases; DNA Repair; DNA-Activated Protein Kinase; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Induction; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Multienzyme Complexes; Neuroblastoma; Nuclear Proteins; Oligopeptides; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins | 2001 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Antigens, Nuclear; Autoantigens; Base Sequence; Binding Sites; Carrier Proteins; Cell Nucleus Structures; Co-Repressor Proteins; CREB-Binding Protein; Green Fluorescent Proteins; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Molecular Chaperones; Molecular Sequence Data; Neoplasm Proteins; Nuclear Proteins; Nuclear Receptor Coactivator 2; Nuclear Receptor Coactivator 3; Peptide Hydrolases; Promyelocytic Leukemia Protein; Protease Inhibitors; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sequence Deletion; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins; Ubiquitins | 2001 |
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression.
Topics: Acetylcysteine; Adenosine Triphosphate; Antigens, Neoplasm; Cell Cycle; Cell Extracts; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Isoenzymes; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2001 |
UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation.
Topics: Acetylcysteine; Alkaloids; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle Proteins; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Glycoproteins; Humans; Protein Biosynthesis; Staurosporine; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Immunoenzyme Techniques; Membrane Potentials; Mitochondria; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Synucleins; Tetracycline; Transfection | 2001 |
Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway.
Topics: Acetylcysteine; Alternative Splicing; Animals; Calpain; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytokines; Dimerization; Enzyme Inhibitors; Enzyme Stability; Humans; Lysosomes; Mice; Multienzyme Complexes; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Serine Proteinase Inhibitors; Transcription, Genetic | 2001 |
Pro-caspase-3 overexpression sensitises ovarian cancer cells to proteasome inhibitors.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Division; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Induction; Female; Flow Cytometry; G2 Phase; Glycoproteins; Humans; Immunoblotting; Isoenzymes; Leupeptins; Ovarian Neoplasms; Transfection | 2001 |
Glutathiolation of the proteasome is enhanced by proteolytic inhibitors.
Topics: Acetylcysteine; Animals; Base Sequence; Clone Cells; Cysteine; Cysteine Endopeptidases; DNA Primers; Glutamate-Cysteine Ligase; Glutathione; Glutathione Disulfide; In Vitro Techniques; Lactones; Liver; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; RNA, Messenger; Sulfones | 2001 |
A novel enantioselective synthetic route to omuralide analogues with the potential for species selectivity in proteasome inhibition.
Topics: Acetylcysteine; Catalysis; Cysteine Endopeptidases; Glycine; Lactates; Lactones; Molecular Structure; Multienzyme Complexes; Proteasome Endopeptidase Complex; Stereoisomerism; Structure-Activity Relationship | 2001 |
Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation.
Topics: Acetylcysteine; Animals; beta Catenin; Culture Media, Conditioned; Cycloheximide; Cytoskeletal Proteins; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Membrane Proteins; Mice; Mutation; Phosphorylation; Presenilin-1; Protein Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins; Signal Transduction; Time Factors; Trans-Activators; Transfection; Tumor Cells, Cultured; Wnt Proteins; Wnt3 Protein; Wnt3A Protein; Zebrafish Proteins | 2001 |
Clustering of peptide-loaded MHC class I molecules for endoplasmic reticulum export imaged by fluorescence resonance energy transfer.
Topics: Acetylcysteine; Amino Acid Sequence; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Bacterial Proteins; Cell Line; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Energy Transfer; Gene Products, tax; Green Fluorescent Proteins; HeLa Cells; HLA-A2 Antigen; Human T-lymphotropic virus 1; Humans; Luminescent Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Transport; Recombinant Fusion Proteins; Spectrometry, Fluorescence | 2001 |
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Topics: Acetylcysteine; Antimalarials; Cell Line; Chloroquine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endocytosis; Humans; Immunoblotting; Leupeptins; Microscopy, Fluorescence; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Sorting Signals; Protein Subunits; Receptors, Interleukin-2; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.
Topics: 14-3-3 Proteins; Acetylcysteine; alpha-Synuclein; Carrier Proteins; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum Chaperone BiP; Exons; Heat-Shock Proteins; Humans; Huntingtin Protein; Huntington Disease; Immunoblotting; Inclusion Bodies; Membrane Proteins; Microscopy, Fluorescence; Models, Biological; Molecular Chaperones; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Peptide Fragments; Poly(A)-Binding Proteins; Proteasome Endopeptidase Complex; Proteins; Recombinant Fusion Proteins; RNA-Binding Proteins; Synucleins; T-Cell Intracellular Antigen-1; Transgenes; Tyrosine 3-Monooxygenase; Vimentin | 2001 |
Characterization of membrane-associated proteasomes in WB rat liver epithelial cells.
Topics: Acetylcysteine; Animals; Anion Exchange Resins; Blotting, Western; Calcium; Cathepsins; Cell Cycle Proteins; Cell Membrane; Cells, Cultured; Chromatography; Chromatography, Ion Exchange; Chymotrypsin; Cysteine Endopeptidases; Cytosol; Detergents; Dose-Response Relationship, Drug; Endopeptidases; Endoplasmic Reticulum; Epithelium; Liver; Multienzyme Complexes; Peptide Hydrolases; Precipitin Tests; Proteasome Endopeptidase Complex; Proteins; Rats; Resins, Synthetic; Sodium Dodecyl Sulfate | 2001 |
3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.
Topics: Acetylcysteine; Animals; Cathepsin L; Cathepsins; Cell Extracts; Cell Line; Cell Membrane Permeability; Cricetinae; Cysteine Endopeptidases; Endopeptidases; Endoplasmic Reticulum; Epoxy Compounds; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Intracellular Membranes; Leucine; Lysosomes; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyridines; Sonication; Sterols | 2001 |
Protein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ferritins; Free Radicals; Hydrogen Peroxide; Liver; Multienzyme Complexes; Naphthols; Nitric Oxide; Oxidation-Reduction; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteins; Rats; Singlet Oxygen; Tyrosine | 2001 |
Impairment of the ubiquitin-proteasome system by protein aggregation.
Topics: Acetylcysteine; Amino Acid Sequence; Cell Death; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; G2 Phase; Green Fluorescent Proteins; Humans; Huntingtin Protein; Inclusion Bodies; Leupeptins; Luminescent Proteins; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Nuclear Proteins; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
cDNA expression arrays: the effects of lactacystin in lipopolysaccharide-induced cystitis.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Cystitis; Gene Expression Regulation; Lipopolysaccharides; Mice; NF-kappa B; Oligonucleotide Array Sequence Analysis; Translocation, Genetic | 2001 |
Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation.
Topics: 3T3 Cells; Acetylcysteine; Animals; Apoptosis; Carcinoma, Medullary; Cell Nucleus; Cell Transformation, Neoplastic; Dimerization; DNA-Binding Proteins; DNA, Neoplasm; Drosophila Proteins; Fibroblasts; Humans; I-kappa B Kinase; I-kappa B Proteins; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; ras Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thyroid Neoplasms; Transcription Factor RelA; Transcription, Genetic; Tumor Cells, Cultured | 2001 |
Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells.
Topics: Acetylcysteine; Blotting, Northern; Catalase; Cell Line, Transformed; Dimerization; Endothelium, Vascular; Enzyme Induction; Free Radical Scavengers; Gene Expression Regulation; Humans; Hydrogen Peroxide; Intercellular Adhesion Molecule-1; Mercaptoethylamines; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Phosphorylation; Prodrugs; Pyruvates; Radiation-Protective Agents; RNA, Messenger; Skin; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2001 |
p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7.
Topics: Acetophenones; Acetylcysteine; Animals; Benzopyrans; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; DNA-Binding Proteins; Humans; Infant, Newborn; Keratinocytes; Multienzyme Complexes; Oncogene Proteins, Viral; Proteasome Endopeptidase Complex; Protein Kinase C; Rabbits | 2001 |
Antitumor bicyclic hexapeptide RA-VII modulates cyclin D1 protein level.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Blotting, Northern; Blotting, Western; Cell Cycle; Cyclin D1; Cycloheximide; Cysteine Proteinase Inhibitors; Formazans; Humans; Peptides, Cyclic; Protein Synthesis Inhibitors; RNA, Messenger; Tetrazolium Salts; Tumor Cells, Cultured | 2001 |
Apolipoprotein E in macrophages and hepatocytes is eegraded via the proteasomal pathway.
Topics: Acetylcysteine; Animals; Apolipoproteins E; Arteriosclerosis; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hepatocytes; Humans; In Vitro Techniques; Macrophages; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Transfection; Ubiquitins | 2001 |
Glucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathway.
Topics: 3T3 Cells; Acetylcysteine; Animals; Cathepsin B; Cathepsin D; Cathepsin L; Cathepsins; Cell Transformation, Neoplastic; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Fibroblasts; Genes, ras; Glucose; Humans; Kinetics; Kirsten murine sarcoma virus; L-Lactate Dehydrogenase; Lysosomes; Methionine; Methylamines; Mice; Protein Biosynthesis; Proteins; Tumor Cells, Cultured | 2001 |
Down-regulation of MET, the receptor for hepatocyte growth factor.
Topics: Acetylcysteine; Cysteine Proteinase Inhibitors; Down-Regulation; Endocytosis; Endosomes; HeLa Cells; Hepatocyte Growth Factor; Humans; Proto-Oncogene Proteins c-met | 2001 |
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
Topics: Acetylcysteine; Animals; Humans; Immunohistochemistry; Iodide Peroxidase; Kinetics; Mesothelioma; Microscopy, Confocal; Microscopy, Fluorescence; Propylthiouracil; Proteins; RNA, Messenger; Selenium; Selenoproteins; Transfection; Tumor Cells, Cultured | 2001 |
Glycosylation increases potassium channel stability and surface expression in mammalian cells.
Topics: Acetylcysteine; Animals; Biotinylation; Cell Line; Cytoplasm; Electrophysiology; Glycosylation; Humans; Lysosomes; Microscopy, Fluorescence; Mutation; Potassium Channels; Precipitin Tests; Protein Folding; Shaker Superfamily of Potassium Channels; Time Factors; Transfection | 2001 |
Stimulation of HIV gp120-specific cytolytic T lymphocyte responses in vitro and in vivo using a detoxified pertussis toxin vector.
Topics: Acetylcysteine; Adjuvants, Immunologic; Animals; Antiviral Agents; Brefeldin A; CD8-Positive T-Lymphocytes; Cell Line; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Genetic Vectors; Histocompatibility Antigens Class I; HIV Envelope Protein gp120; HIV-1; Humans; Mice; Mice, Inbred BALB C; Peptide Fragments; Pertussis Toxin; Recombinant Fusion Proteins; T-Lymphocytes, Cytotoxic; Virulence Factors, Bordetella | 2001 |
Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production.
Topics: Acetylcysteine; Cell Physiological Phenomena; Cell Survival; Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; Free Radicals; Glutathione; Humans; Lipid Metabolism; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrogen; Oxidative Stress; Proteasome Endopeptidase Complex; Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Tumor Cells, Cultured; Tyrosine; Ubiquitins | 2001 |
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Adenoviridae; Amino Acids; Animals; Biological Transport; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cysteine Endopeptidases; Cytosol; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Eukaryotic Initiation Factors; Glucose; Humans; Immunoblotting; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Sirolimus; Subcellular Fractions; Threonine; Time Factors; TOR Serine-Threonine Kinases; Tyrosine | 2001 |
Dendritic growth induced by BMP-7 requires Smad1 and proteasome activity.
Topics: Acetylcysteine; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendrites; DNA-Binding Proteins; Gene Expression; Leupeptins; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Smad Proteins; Smad1 Protein; Superior Cervical Ganglion; Trans-Activators; Transcriptional Activation; Transfection; Transforming Growth Factor beta | 2001 |
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.
Topics: Acetylcysteine; Brain; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Ligases; Microscopy, Fluorescence; Parkinsonian Disorders; Precipitin Tests; Protein Binding; Protein Folding; Receptors, Cell Surface; Recombinant Fusion Proteins; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins | 2001 |
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins | 2001 |
Transcriptionally and post-transcriptionally regulated response of 13 calmodulin genes to tobacco mosaic virus-induced cell death and wounding in tobacco plant.
Topics: Acetates; Acetylcysteine; Calmodulin; Cloning, Molecular; Cyclopentanes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation, Plant; Genes, Plant; Multienzyme Complexes; Nicotiana; Oxylipins; Plant Diseases; Plant Growth Regulators; Plant Leaves; Plants, Toxic; Proteasome Endopeptidase Complex; Protein Isoforms; RNA Processing, Post-Transcriptional; Salicylic Acid; Signal Transduction; Tissue Distribution; Tobacco Mosaic Virus | 2001 |
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) escapes O(2)-driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antibiotics, Antineoplastic; Cell Fractionation; Cell Hypoxia; Cell Line; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Fatty Acids, Unsaturated; Humans; Immunoblotting; Multienzyme Complexes; Oxygen; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sodium-Hydrogen Exchangers; Transcription Factors; Transfection | 2001 |
Preventive effect of lactacystin, a selective proteasome inhibitor, on ischemic acute renal failure in rats.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endothelin-1; Ischemia; Kidney; Male; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury | 2001 |
Effects of lipofectin-antigen complexes on major histocompatibility complex class I-restricted antigen presentation pathway in murine dendritic cells and on dendritic cell maturation.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens; Brefeldin A; Cell Line; Cell Survival; Chloroquine; Cytochalasin B; Dendritic Cells; Histocompatibility Antigens Class I; Major Histocompatibility Complex; Mice; Ovalbumin; Phosphatidylethanolamines; Time Factors | 2001 |
Efficient presentation of both cytosolic and endogenous transmembrane protein antigens on MHC class II is dependent on cytoplasmic proteolysis.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Antigen Presentation; Antigen-Presenting Cells; Cell Line; Conalbumin; Cysteine Endopeptidases; Cytosol; Endocytosis; Endosomes; Histocompatibility Antigens Class II; Membrane Proteins; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Multienzyme Complexes; Ovalbumin; Pinocytosis; Protease Inhibitors; Proteasome Endopeptidase Complex | 2001 |
Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines.
Topics: Acetylcysteine; Apoptosis; Calpain; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Eukaryotic Initiation Factor-4G; fas Receptor; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Jurkat Cells; Leupeptins; Multienzyme Complexes; Peptide Fragments; Peptide Initiation Factors; Propylene Glycols; Proteasome Endopeptidase Complex; Sphingosine; T-Lymphocytes | 2001 |
A measles virus glycoprotein-derived human CTL epitope is abundantly presented via the proteasomal-dependent MHC class I processing pathway.
Topics: Acetylcysteine; Amino Acid Sequence; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Cysteine Endopeptidases; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class I; Humans; Measles virus; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; U937 Cells; Viral Fusion Proteins | 2001 |
Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptotic Protease-Activating Factor 1; Blotting, Western; Caspase 9; Caspases; Cysteine Endopeptidases; Cytochrome c Group; Cytosol; Enzyme Activation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leupeptins; Microscopy, Electron; Molecular Weight; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Biosynthesis; Proteins; Tumor Cells, Cultured | 2001 |
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells.
Topics: Acetylcysteine; alpha-Synuclein; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Cell Differentiation; Cyclic AMP; Cysteine Endopeptidases; Immunoblotting; Immunohistochemistry; Inclusion Bodies; Lewy Body Disease; Multienzyme Complexes; Nerve Tissue Proteins; Neuroprotective Agents; Oligopeptides; Parkinson Disease; PC12 Cells; Protease Inhibitors; Proteasome Endopeptidase Complex; Rats; Synucleins; Ubiquitins | 2001 |
Preconditioning-induced neuroprotection is mediated by reactive oxygen species and activation of the transcription factor nuclear factor-kappaB.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Astrocytes; Cells, Cultured; Cycloheximide; Enzyme Inhibitors; Ferrous Compounds; Hippocampus; Immunoblotting; Immunohistochemistry; Neurons; NF-kappa B; Protein Synthesis Inhibitors; Rats; Rats, Inbred F344; Reactive Oxygen Species; Staurosporine; Superoxide Dismutase; Xanthine; Xanthine Oxidase | 2001 |
Proteasome inhibitors induce Fas-mediated apoptosis by c-Myc accumulation and subsequent induction of FasL message in human glioma cells.
Topics: Acetylcysteine; Apoptosis; Base Sequence; Brain Neoplasms; Cysteine Proteinase Inhibitors; DNA Primers; Fas Ligand Protein; fas Receptor; Glioma; Humans; Leupeptins; Membrane Glycoproteins; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured | 2001 |
Proteolysis of oxidized proteins after oxygen-glucose deprivation in rat cortical neurons is mediated by the proteasome.
Topics: Acetylcysteine; Animals; Brain Ischemia; Cell Death; Cells, Cultured; Cerebral Cortex; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glucose; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Oxidative Stress; Oxygen; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Reactive Oxygen Species | 2001 |
Antigen processing for MHC class I restricted presentation of exogenous influenza A virus nucleoprotein by B-lymphoblastoid cells.
Topics: Acetylcysteine; Antigen Presentation; B-Lymphocytes; Brefeldin A; Chloroquine; Endosomes; Enzyme Inhibitors; Hematopoietic Stem Cells; Histocompatibility Antigens Class I; Humans; Influenza A virus; Major Histocompatibility Complex; Nucleocapsid Proteins; Nucleoproteins; Peptide Fragments; RNA-Binding Proteins; Viral Core Proteins | 2001 |
Ubiquitination precedes internalization and proteolytic cleavage of plasma membrane-bound glycine receptors.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Cell Membrane; Cysteine Endopeptidases; DNA, Complementary; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycine; Histidine; Hydrogen-Ion Concentration; Lysine; Lysosomes; Macrolides; Models, Biological; Multienzyme Complexes; Mutagenesis, Site-Directed; Oocytes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Binding; RNA, Complementary; Ubiquitin; Xenopus | 2001 |
Proteasome inhibitors differentially affect heat shock protein response in cancer cells.
Topics: Acetylcysteine; Antigens, Neoplasm; Blotting, Western; Cell Division; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Heat-Shock Proteins; HL-60 Cells; Humans; K562 Cells; Leupeptins; Multienzyme Complexes; Neoplasms; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2001 |
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
Topics: Acetylcysteine; Catalytic Domain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; HeLa Cells; Humans; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Peptides; Proteasome Endopeptidase Complex; Sulfones | 2001 |
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; HeLa Cells; Hepatocytes; Humans; Lactones; Leupeptins; Liver; Mice; Multienzyme Complexes; Mutation; Oligopeptides; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Rats; Time Factors; Transfection; Tumor Cells, Cultured | 2001 |
Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells.
Topics: Acetylcysteine; Benzamides; Cell Nucleus; Cysteine Endopeptidases; Enzyme Inhibitors; Histones; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Multienzyme Complexes; Oxidation-Reduction; Oxidative Stress; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex | 2001 |
A convenient method for 3-pyrroline synthesis.
Topics: Acetylcysteine; Alkylation; Anti-Bacterial Agents; Combinatorial Chemistry Techniques; Cyclization; Lactams; Pyrroles; Stereoisomerism | 2001 |
Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcysteine; Amino Acid Motifs; Amino Acid Sequence; Calcium-Binding Proteins; Catalysis; Cell Line; Cyclic AMP; Cysteine Endopeptidases; Endosomal Sorting Complexes Required for Transport; Enzyme Activation; Gene Deletion; Glutathione Transferase; Guanine Nucleotide Exchange Factors; Humans; Ligases; Molecular Sequence Data; Multienzyme Complexes; Mutation; Nedd4 Ubiquitin Protein Ligases; Nerve Tissue Proteins; Nucleotides, Cyclic; Plasmids; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Protein Structure, Tertiary; ras Guanine Nucleotide Exchange Factors; ras Proteins; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Time Factors; Transfection; Ubiquitin; Ubiquitin-Protein Ligases | 2001 |
Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway.
Topics: Acetylcysteine; Animals; Cell Cycle Proteins; Cell Fractionation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flow Cytometry; G1 Phase; G2 Phase; Ionomycin; Ionophores; Lymphocytes; Mice; Mice, Knockout; Models, Biological; Multienzyme Complexes; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; S Phase; S-Phase Kinase-Associated Proteins; Tumor Suppressor Proteins; Ubiquitin | 2001 |
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.
Topics: Acetylcysteine; Animals; Apoptosis; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Enzyme Activation; Female; Fibroblasts; Gene Targeting; Genes, Reporter; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Lung; Lymphocyte Subsets; Male; Mice; Mice, Knockout; NF-kappa B; NF-KappaB Inhibitor alpha; Peyer's Patches; Phenotype; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Recombinant Proteins; Spleen; Transcription Factor RelA; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival.
Topics: Acetylcysteine; Amino Acid Motifs; Animals; Apoptosis; Carbon Tetrachloride; Caspase Inhibitors; Caspases; CCAAT-Enhancer-Binding Protein-beta; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Enzyme Activation; Enzyme Precursors; Hepatocytes; Humans; Liver Cirrhosis, Experimental; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Phosphorylation; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases | 2001 |
Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.
Topics: Acetylcysteine; Animals; Behavior, Animal; Cell Death; Cell Survival; Cells, Cultured; Corpus Striatum; Cysteine Endopeptidases; Disease Models, Animal; Gene Silencing; Genes, Dominant; Huntingtin Protein; Huntington Disease; Locomotion; Macromolecular Substances; Mice; Mice, Neurologic Mutants; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Phenotype; Proteasome Endopeptidase Complex; Remission Induction; Tetracycline; Transgenes; Ubiquitin | 2001 |
Reversion of temperature-sensitive mutation by inhibition of proteasome-mediated degradation of mutated D123 protein.
Topics: Acetylcysteine; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Cycle Proteins; Cell Division; Cell Line, Transformed; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Genetic Complementation Test; Hybrid Cells; Leupeptins; Multienzyme Complexes; Point Mutation; Proteasome Endopeptidase Complex; Proteins; Rats; Temperature; Ubiquitin | 2001 |
The glycoprotein gp48 of murine cytomegalovirusL proteasome-dependent cytosolic dislocation and degradation.
Topics: 3T3 Cells; Acetylcysteine; Amino Acid Sequence; Animals; Base Sequence; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytomegalovirus Infections; Cytosol; DNA Primers; Hydrolysis; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Transport; Viral Envelope Proteins | 2002 |
Inhibition of proteasome activity blocks the ability of TNF alpha to down-regulate G(i) proteins and stimulate lipolysis.
Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Down-Regulation; GTP-Binding Protein alpha Subunits, Gi-Go; Lipolysis; Male; Multienzyme Complexes; Phenylisopropyladenosine; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2001 |
Photic regulation of melatonin in rat retina and the role of proteasomal proteolysis.
Topics: Acetylcysteine; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Male; Melatonin; Multienzyme Complexes; Peptide Hydrolases; Photic Stimulation; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Retina; RNA, Messenger | 2001 |
Divers pathways mediate delta-opioid receptor down regulation within the same cell.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Antirheumatic Agents; Chloroquine; Cysteine Proteinase Inhibitors; Diprenorphine; Down-Regulation; Etorphine; Flavonoids; Genistein; GTP-Binding Proteins; Humans; Kidney; MAP Kinase Signaling System; Narcotic Antagonists; Neuroblastoma; Phosphorylation; Radioligand Assay; Receptors, Opioid, delta; Staurosporine; Teprotide; Transfection; Tritium; Tumor Cells, Cultured | 2001 |
The molecular basis of glycogen storage disease type 1a: structure and function analysis of mutations in glucose-6-phosphatase.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; beta-Galactosidase; Binding Sites; Blotting, Western; Cell Membrane; Codon; COS Cells; Cysteine Proteinase Inhibitors; Cytoplasm; DNA, Complementary; Endoplasmic Reticulum; Exons; Gene Deletion; Genotype; Glucose; Glucose-6-Phosphatase; Glycogen Storage Disease Type I; Heterozygote; Homeostasis; Homozygote; Humans; Immunoblotting; Molecular Sequence Data; Mutation; Mutation, Missense; Phenotype; Phosphoric Monoester Hydrolases; Polymorphism, Single-Stranded Conformational; Protein Biosynthesis; Protein Structure, Tertiary; Structure-Activity Relationship; Time Factors; Transcription, Genetic; Transfection | 2002 |
Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hippocampus; Homer Scaffolding Proteins; Immunohistochemistry; Leupeptins; Multienzyme Complexes; Neuronal Plasticity; Neurons; Neuropeptides; Proteasome Endopeptidase Complex; Synapses; Synaptophysin | 2001 |
Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.
Topics: Acetylcysteine; beta Catenin; Blotting, Western; Colorectal Neoplasms; Cyclin D1; Cytoskeletal Proteins; Desmoplakins; DNA; Dose-Response Relationship, Drug; Down-Regulation; Electrophoretic Mobility Shift Assay; gamma Catenin; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Interleukin-2; Isoenzymes; Nitrobenzenes; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-myc; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sulfonamides; Trans-Activators; Transcription Factors; Tumor Cells, Cultured | 2002 |
Identification and characterization of two novel mutations (Q421 K and R123P) in congenital factor XII deficiency.
Topics: Acetylcysteine; Adolescent; Amino Acid Substitution; Animals; Brefeldin A; CHO Cells; Codon; Cricetinae; Cricetulus; Cysteine Endopeptidases; DNA Mutational Analysis; Exons; Factor XII; Factor XII Deficiency; Heterozygote; Homozygote; Humans; Male; Middle Aged; Multienzyme Complexes; Mutation, Missense; Partial Thromboplastin Time; Pedigree; Point Mutation; Polymerase Chain Reaction; Protease Inhibitors; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Transfection | 2001 |
Proteasome inhibitors activate the transcription factors C/EBP-beta and delta in human intestinal epithelial cells.
Topics: Acetylcysteine; Blotting, Western; Caco-2 Cells; CCAAT-Enhancer-Binding Protein-beta; CCAAT-Enhancer-Binding Protein-delta; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Dose-Response Relationship, Drug; Enterocytes; Enzyme Activation; Epithelial Cells; Heat-Shock Proteins; Hot Temperature; HSP72 Heat-Shock Proteins; Humans; Intestinal Mucosa; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Isoforms; Quercetin; Temperature; Time Factors; Transcription Factors | 2002 |
Long term regulation of aquaporin-2 expression in vasopressin-responsive renal collecting duct principal cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcysteine; Animals; Aquaporin 2; Aquaporin 6; Aquaporins; Blotting, Western; Cell Line; Cells, Cultured; Colforsin; Cysteine Endopeptidases; Dactinomycin; Deamino Arginine Vasopressin; Dose-Response Relationship, Drug; Gene Expression Regulation; Kidney Tubules, Collecting; Lysosomes; Mice; Microscopy, Fluorescence; Multienzyme Complexes; Nucleic Acid Synthesis Inhibitors; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; Rats; Ribonucleases; RNA, Messenger; RNA, Ribosomal, 18S; Time Factors; Vasopressins | 2002 |
Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calnexin; Calreticulin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycoproteins; Indolizines; Metalloendopeptidases; Mice; Models, Biological; Molecular Chaperones; Multienzyme Complexes; Mutation; Oligosaccharides; Proteasome Endopeptidase Complex; Protein Precursors; Protein Processing, Post-Translational; Protein Transport; Ribonucleoproteins; Sequence Deletion; Ubiquitin | 2002 |
Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation.
Topics: Acetylcysteine; Adipocytes; Animals; Calpain; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Kinetics; Leupeptins; Nuclear Proteins; Peptide Hydrolases; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Retinoblastoma-Like Protein p130 | 2002 |
Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase.
Topics: Acetylcysteine; Animals; Arylamine N-Acetyltransferase; Blotting, Western; Chickens; Circadian Rhythm; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Male; Melatonin; Multienzyme Complexes; Photic Stimulation; Pineal Gland; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Rabbits; Retina | 2002 |
Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression.
Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Blotting, Western; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Endotoxins; Heart; Lipopolysaccharides; Mice; Multienzyme Complexes; Myocardium; NF-kappa B; Proteasome Endopeptidase Complex; Pyrrolidines; Reverse Transcriptase Polymerase Chain Reaction; Stress, Physiological; Thiocarbamates; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2002 |
Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Amino Acid Motifs; Arsenites; Blotting, Western; Cdc20 Proteins; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Line; Dose-Response Relationship, Drug; Down-Regulation; G1 Phase; G2 Phase; Humans; Mitosis; Mutagenesis, Site-Directed; Mutation; Peptides; Phosphorylation; Precipitin Tests; Resting Phase, Cell Cycle; Saccharomyces cerevisiae Proteins; Time Factors; Ubiquitin | 2002 |
Presentation of a new H-2D(k)-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Cell Line; Cricetinae; Cysteine Endopeptidases; Cytotoxicity, Immunologic; Epitopes, T-Lymphocyte; Female; Gene Products, tax; Genetic Vectors; H-2 Antigens; Histocompatibility Antigen H-2D; Human T-lymphotropic virus 1; Mice; Mice, Inbred CBA; Molecular Sequence Data; Multienzyme Complexes; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Binding; T-Lymphocytes, Cytotoxic; Vaccinia virus | 2002 |
Proteasome activity is critical for the cAMP-induced differentiation of neuroblastoma cells.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cyclic AMP; Cyclin B; Cyclin B1; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, myc; Green Fluorescent Proteins; Humans; Leupeptins; Luminescent Proteins; Mice; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Retroviridae; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cell Membrane; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasmic Vesicles; Endocytosis; Endopeptidases; Epidermal Growth Factor; ErbB Receptors; Humans; Immunohistochemistry; Intracellular Membranes; Leupeptins; Microscopy, Confocal; Microscopy, Electron; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Transforming Growth Factor alpha; Ubiquitin-Protein Ligases; Ubiquitins | 2002 |
Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Cysteine Proteinase Inhibitors; Exons; Half-Life; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Hybrid Cells; Inclusion Bodies; Mice; Molecular Chaperones; Muscular Atrophy, Spinal; Neurons; Peptide Hydrolases; Polyglutamic Acid; Proteasome Endopeptidase Complex; Receptors, Androgen; Recombinant Proteins; Solubility; Trinucleotide Repeat Expansion | 2002 |
Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Benzoquinones; Brefeldin A; Cell Line; Cell Membrane; CHO Cells; COS Cells; Cricetinae; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Diffusion; DNA, Complementary; Endoplasmic Reticulum; Enzyme Inhibitors; Green Fluorescent Proteins; Lactams, Macrocyclic; Light; Luminescent Proteins; Microscopy, Fluorescence; Molecular Chaperones; Mutagenesis, Site-Directed; Mutation; Protein Synthesis Inhibitors; Quinones; Recombinant Fusion Proteins; Time Factors; Transfection; Tunicamycin | 2002 |
Role of ATP in influenza virus budding.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cell Line; Cell Membrane Permeability; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dogs; Enzyme Inhibitors; Humans; Indoles; Influenza A virus; Kinetics; Leupeptins; Lysophosphatidylcholines; Multienzyme Complexes; Oligopeptides; Ouabain; Proteasome Endopeptidase Complex; Sodium-Potassium-Exchanging ATPase; Sulfones; Thapsigargin; Viscosity | 2001 |
Biosynthesis and secretion of parathyroid hormone are sensitive to proteasome inhibitors in dispersed bovine parathyroid cells.
Topics: Acetylcysteine; Animals; Brefeldin A; Calpain; Cattle; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; HSP70 Heat-Shock Proteins; Multienzyme Complexes; Parathyroid Glands; Parathyroid Hormone; Proteasome Endopeptidase Complex; Protein Precursors | 2002 |
Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum.
Topics: 3T3 Cells; Acetylcysteine; Animals; Antigen Presentation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Epitopes; Female; Gene Targeting; H-2 Antigens; Influenza A virus; L Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Multienzyme Complexes; Nucleocapsid Proteins; Nucleoproteins; Peptide Fragments; Proteasome Endopeptidase Complex; Protein Transport; RNA-Binding Proteins; Viral Core Proteins | 2002 |
Notch receptor cleavage depends on but is not directly executed by presenilins.
Topics: Acetylcysteine; Amino Acid Sequence; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Extracts; Cell Line; Detergents; Endopeptidases; Fluorometry; Humans; Leupeptins; Membrane Proteins; Mice; Mutation; Presenilin-1; Presenilin-2; Protease Inhibitors; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Notch; Signal Transduction; Solubility | 2002 |
Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells.
Topics: Acetylcysteine; Caco-2 Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enterocytes; Epithelial Cells; Gene Expression; Heat Shock Transcription Factors; Heat-Shock Proteins; Heat-Shock Response; HSP72 Heat-Shock Proteins; Humans; Interleukin-6; Intestinal Mucosa; Leupeptins; Multienzyme Complexes; NF-kappa B; Proteasome Endopeptidase Complex; RNA, Messenger; Transcription Factors; Transcriptional Activation | 2002 |
Influence of peroxisome proliferator-activated receptor alpha agonists on the intracellular turnover and secretion of apolipoprotein (Apo) B-100 and ApoB-48.
Topics: Acetylcysteine; Animals; Apolipoprotein B-100; Apolipoprotein B-48; Apolipoproteins B; Cell Line; Cells, Cultured; Clofibrate; Cytosol; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Female; Immunoblotting; Oleic Acid; Palmitic Acid; Protein Binding; Protein Biosynthesis; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Triglycerides; Tumor Cells, Cultured | 2002 |
Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression.
Topics: Acetylcysteine; Antineoplastic Agents; Cisplatin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; DNA Repair; DNA-Binding Proteins; DNA, Neoplasm; Drug Resistance, Neoplasm; Drug Synergism; Endonucleases; Female; Gene Expression; Humans; Multienzyme Complexes; Ovarian Neoplasms; Proteasome Endopeptidase Complex; Proteins; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2001 |
Differential effects of stress stimuli on a JNK-inactivating phosphatase.
Topics: Acetylcysteine; Anisomycin; Arsenites; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Dual-Specificity Phosphatases; Enzyme Stability; Humans; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoproteins; Protein Tyrosine Phosphatases; Transfection | 2002 |
Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome.
Topics: Acetylcysteine; Antioxidants; Blotting, Western; Cell Survival; DNA; Glutathione; Humans; Ligases; Mutation; Nitric Oxide; Nitrogen; Oxidative Stress; Oxygen; Point Mutation; Protein Binding; Superoxide Dismutase; Time Factors; Transfection; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases | 2002 |
Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling.
Topics: Acetylcysteine; Animals; cdc42 GTP-Binding Protein; Cell Adhesion; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Extracellular Matrix; Fibronectins; Humans; Integrins; Mice; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; rac1 GTP-Binding Protein; Signal Transduction; Tumor Suppressor Proteins; Ubiquitin | 2002 |
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures.
Topics: Acetylcysteine; Aldehydes; Animals; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inclusion Bodies; Mesencephalon; Multienzyme Complexes; Neurons; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitin | 2002 |
Nitric oxide-mediated proteasome-dependent oligonucleosomal DNA fragmentation in Leishmania amazonensis amastigotes.
Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA, Protozoan; Female; Glycoproteins; Kinetics; Leishmania mexicana; Leupeptins; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Donors; Proteasome Endopeptidase Complex; Sodium Nitrite; Time Factors | 2002 |
Proteasomal degradation of cytotoxic necrotizing factor 1-activated rac.
Topics: Acetylcysteine; Bacterial Toxins; cdc42 GTP-Binding Protein; Cell Line; Cysteine Proteinase Inhibitors; Cytotoxins; Enzyme Activation; Escherichia coli Proteins; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Peptide Hydrolases; Proteasome Endopeptidase Complex; rac1 GTP-Binding Protein; rhoA GTP-Binding Protein; Signal Transduction | 2002 |
Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons.
Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diterpenes; Dose-Response Relationship, Drug; Glutathione; HSP70 Heat-Shock Proteins; Immunoblotting; Immunohistochemistry; Mitochondria; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spinal Cord; Thioredoxins; Time Factors | 2002 |
Aggresome formation in neuropathy models based on peripheral myelin protein 22 mutations.
Topics: Acetylcysteine; Animals; Carbocyanines; Cells, Cultured; Charcot-Marie-Tooth Disease; Crystallins; Cysteine Endopeptidases; Heat-Shock Proteins; Humans; Inclusion Bodies; Lysosomes; Macromolecular Substances; Mice; Mice, Neurologic Mutants; Microtubules; Multienzyme Complexes; Myelin Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Folding; Protein Processing, Post-Translational; Protein Transport; Rats; Recombinant Fusion Proteins; Schwann Cells; Sciatic Nerve; Ubiquitin | 2002 |
The effect of proteasome inhibitors on mammalian erythroid terminal differentiation.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Differentiation; Cell Line, Transformed; Cell Transformation, Viral; Cysteine Endopeptidases; Cytoplasm; Erythroid Precursor Cells; Erythropoiesis; Friend murine leukemia virus; Leupeptins; Mice; Multienzyme Complexes; Nuclear Proteins; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Reticulocytes; Ubiquitin | 2002 |
Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular signal-related kinase and c-Jun N-terminal kinase activation.
Topics: Acetylcysteine; Cell Line; Chemotaxis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Epithelial Cells; Genes, Reporter; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neutrophils; NF-kappa B; Proteasome Endopeptidase Complex; ras Proteins; Reactive Oxygen Species; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured | 2002 |
Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; alpha-Synuclein; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Herbicides; Humans; In Vitro Techniques; Kidney; Membrane Glycoproteins; Membrane Transport Proteins; Multienzyme Complexes; Mutagenesis; Nerve Tissue Proteins; Proteasome Endopeptidase Complex; Rotenone; Synucleins; Transfection; Uncoupling Agents | 2002 |
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Dopamine; Dose-Response Relationship, Drug; Inclusion Bodies; Multienzyme Complexes; Neurons; Parkinson Disease; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Striatonigral Degeneration; Substantia Nigra | 2002 |
Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Hepatocytes; HSP70 Heat-Shock Proteins; Hydrocortisone; Leupeptins; Multienzyme Complexes; Oncorhynchus mykiss; Proteasome Endopeptidase Complex; Receptors, Glucocorticoid; Sulfur Radioisotopes | 2002 |
The DNA repair protein, O(6)-methylguanine-DNA methyltransferase is a proteolytic target for the E6 human papillomavirus oncoprotein.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Binding Sites; Cysteine Proteinase Inhibitors; DNA Repair; DNA-Binding Proteins; Down-Regulation; Humans; Ligases; Magnesium; O(6)-Methylguanine-DNA Methyltransferase; Oncogene Proteins, Viral; Rabbits; Repressor Proteins; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitin; Ubiquitin-Protein Ligases | 2002 |
Proteasome inhibitors regulate tyrosine phosphorylation of IRS-1 and insulin signaling in adipocytes.
Topics: 3T3 Cells; Acetylcysteine; Adipocytes; Animals; Biological Transport; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glucose; Insulin; Insulin Receptor Substrate Proteins; Kinetics; Leupeptins; Mice; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2002 |
Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.
Topics: Acetylcysteine; Antioxidants; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Genes, Reporter; Humans; Interleukin-8; Leupeptins; Luciferases; Multienzyme Complexes; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Recombinant Proteins; Transcription Factor AP-1; Transfection | 2002 |
Proteasome inhibitors induce apoptosis in growth hormone- and prolactin-secreting rat pituitary tumor cells.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspases; Cells, Cultured; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Female; Growth Hormone; In Situ Nick-End Labeling; Leupeptins; Multienzyme Complexes; Pituitary Gland, Anterior; Pituitary Neoplasms; Prolactinoma; Proteasome Endopeptidase Complex; Rats; Tumor Cells, Cultured | 2002 |
Aberrant apoptosis in thyroid epithelial cells from goiter nodules.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; fas Receptor; Goiter, Nodular; Humans; Immunoblotting; Interferon-gamma; Keratins; Membrane Glycoproteins; Recombinant Proteins; Reference Values; Thyroid Gland; Thyroidectomy; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha | 2002 |
Accelerated degradation of mislocalized UDP-glucuronosyltransferase family 1 (UGT1) proteins in Gunn rat hepatocytes.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glucuronosyltransferase; Glycoproteins; Half-Life; Hepatocytes; Leupeptins; Male; Monosaccharide Transport Proteins; Multienzyme Complexes; Mutation; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Gunn; Rats, Wistar; RNA, Messenger; Subcellular Fractions | 2002 |
Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters.
Topics: Acetylcysteine; Apolipoprotein A-I; Apolipoproteins B; Apolipoproteins E; Cholesterol Esters; Endoplasmic Reticulum; Flavanones; Flavonoids; Hepatocytes; Humans; Kinetics; Microsomes, Liver; Oleic Acid; Triglycerides; Tumor Cells, Cultured | 2002 |
Proteasomal degradation of tau protein.
Topics: Acetylcysteine; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Multienzyme Complexes; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Folding; Protein Isoforms; tau Proteins; Transfection; Tumor Cells, Cultured; Ubiquitin | 2002 |
The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Aminopeptidases; Antigen Presentation; Cell Line; Cytosol; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; HLA-B Antigens; HLA-B51 Antigen; Humans; Hydrolysis; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Proline; Protein Precursors; Protein Processing, Post-Translational; Puromycin; Serine Endopeptidases; T-Lymphocytes, Cytotoxic; Transfection; Tumor Cells, Cultured | 2002 |
Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells.
Topics: Acetylcysteine; Animals; Blood Proteins; Blotting, Western; Catalysis; Cell Line; Cell Size; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Hydrogen Peroxide; Liver; Membrane Proteins; Microfilament Proteins; Multienzyme Complexes; Oligopeptides; Oxidative Stress; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Rats; Sulfones | 2002 |
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosol; Endopeptidase K; Endoplasmic Reticulum; Leupeptins; Mice; Models, Biological; Multienzyme Complexes; Neurons; Oligopeptides; Prions; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Transport; PrPSc Proteins; Solubility; Transfection; Tumor Cells, Cultured | 2002 |
Multiple forms of estrogen receptor-alpha in cerebral blood vessels: regulation by estrogen.
Topics: Acetylcysteine; Animals; Blood Vessels; Blotting, Western; Brain; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Estradiol; Estrogen Receptor alpha; Female; Immunohistochemistry; Microscopy, Confocal; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Ovariectomy; Peptide Hydrolases; Phosphorylation; Phosphoserine; Pia Mater; Proteasome Endopeptidase Complex; Rats; Rats, Inbred F344; Receptors, Estrogen | 2003 |
Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen.
Topics: Acetylcysteine; Animals; Antigen Presentation; Autoantigens; Cell Line; Cell Nucleus; Chromosomal Proteins, Non-Histone; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dual-Specificity Phosphatases; Female; Humans; Mercuric Chloride; Mice; Multienzyme Complexes; Peptide Hydrolases; Phosphoproteins; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; Rats; Spleen; Ubiquitin | 2002 |
Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice.
Topics: Acetylcysteine; Animals; Behavior, Animal; Brain; Cognition; Cysteine Proteinase Inhibitors; Embryonic and Fetal Development; Fertility; Fibroblasts; Gene Expression Regulation, Developmental; Heat-Shock Proteins; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Psychomotor Performance; Testis; Transcription Factors | 2002 |
Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Animals, Newborn; Brain Chemistry; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Embryo, Mammalian; Enzyme Inhibitors; Hippocampus; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Okadaic Acid; Phosphorylation; Proteasome Endopeptidase Complex; Purines; Rats; Rats, Wistar; Roscovitine | 2002 |
Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Anti-Bacterial Agents; Aspartic Acid Endopeptidases; Cell Line; Dimerization; Dynamins; Endosomes; Endothelin-Converting Enzymes; Enzyme Inhibitors; Isoenzymes; Macrolides; Metalloendopeptidases; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Pituitary Gland; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2003 |
Proteasome-dependent downregulation of p21(Waf1/Cip1) induced by reactive oxygen species.
Topics: Acetylcysteine; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Cysteine Endopeptidases; Doxorubicin; Fibroblasts; HeLa Cells; Humans; Hydrogen Peroxide; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oxidative Stress; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Reactive Oxygen Species | 2002 |
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop.
Topics: Acetylcysteine; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Blood; Cell Line; Cycloheximide; Cysteine Endopeptidases; Feedback, Physiological; Gene Expression Regulation; Glycosyltransferases; Half-Life; Homeodomain Proteins; Leupeptins; Mesoderm; Mice; Multienzyme Complexes; PC12 Cells; Periodicity; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Synthesis Inhibitors; Rats; RNA, Messenger; Transcription Factor HES-1; Transcription, Genetic; Transfection; Ubiquitin | 2002 |
Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
Topics: Acetylcysteine; Blotting, Western; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Deferoxamine; Ferric Compounds; Humans; Iron; Iron Chelating Agents; Multienzyme Complexes; Oxidation-Reduction; Proteasome Endopeptidase Complex; Proteins; Quaternary Ammonium Compounds; Tumor Cells, Cultured | 2002 |
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.
Topics: Acetylcysteine; Acute Disease; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-X Protein; Cell Transformation, Viral; Enzyme Activation; Gene Expression Regulation, Viral; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 8, Human; Humans; I-kappa B Proteins; Leukemia, Myeloid; Leupeptins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; NF-kappa B; Oxides; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Recombinant Proteins; Rhadinovirus; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Proteins | 2003 |
Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor, lactacystin.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cysteine Endopeptidases; Drug Synergism; Genistein; Mast Cells; Mastocytoma; Mice; Multienzyme Complexes; NF-kappa B; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2002 |
Synphilin-1 degradation by the ubiquitin-proteasome pathway and effects on cell survival.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Blotting, Western; Carrier Proteins; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Humans; Inclusion Bodies; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Macromolecular Substances; Mice; Multienzyme Complexes; Nerve Tissue Proteins; Neuroblastoma; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Synucleins; Transfection; Ubiquitin | 2002 |
The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21 (WAF1/CIP1 expression).
Topics: Acetylcysteine; Binding Sites; Butyrophenones; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA Damage; Dose-Response Relationship, Drug; G2 Phase; Gene Expression; Humans; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Sustained activation of N-WASP through phosphorylation is essential for neurite extension.
Topics: Acetylcysteine; Actin-Related Protein 2; Actin-Related Protein 3; Amino Acid Sequence; Animals; cdc42 GTP-Binding Protein; Cell Line; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Female; Leupeptins; Mice; Mice, Inbred ICR; Molecular Sequence Data; Multienzyme Complexes; Nerve Tissue Proteins; Neurites; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Rats; Spodoptera; src-Family Kinases; Wiskott-Aldrich Syndrome Protein, Neuronal | 2002 |
Cytosolic and nuclear aggregation of the amyloid beta-peptide following its expression in the endoplasmic reticulum.
Topics: Acetylcysteine; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Biological Transport, Active; Cell Nucleus; CHO Cells; Cricetinae; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Ubiquitin | 2002 |
Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type Ib.
Topics: Acetylcysteine; Adenoviridae; Amino Acid Sequence; Animals; Antiporters; Cell Line; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Genetic Vectors; Glucose-6-Phosphatase; Glucose-6-Phosphate; Glycogen Storage Disease Type I; Humans; Intracellular Membranes; Microsomes; Molecular Sequence Data; Monosaccharide Transport Proteins; Multienzyme Complexes; Mutation, Missense; Peptides; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Sequence Deletion; Structure-Activity Relationship; Viral Proteins | 2002 |
[Embryonal stem cells do not undergo cell cycle arrest upon exposure to damaging factors].
Topics: Acetylcysteine; Animals; Aspartic Acid; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Doxorubicin; Embryo, Mammalian; Mice; Nocodazole; Phosphonoacetic Acid; Stem Cells; Tumor Cells, Cultured | 2002 |
Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase.
Topics: Acetylcysteine; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Line; Cell-Free System; Cells, Cultured; Cysteine Proteinase Inhibitors; Endopeptidases; Fibroblasts; Humans; Membrane Proteins; Mice; Mice, Knockout; Molecular Structure; Mutation; Protein Structure, Tertiary; Receptor, Notch1; Receptors, Cell Surface; Transcription Factors; Valine | 2002 |
Nuclear phosphatases and the proteasome in suppression of STAT1 activity in hepatocytes.
Topics: Acetylcysteine; Cell Cycle Proteins; Complement C1 Inactivator Proteins; Complement C1 Inhibitor Protein; Cysteine Endopeptidases; DNA-Binding Proteins; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Hepatocytes; Humans; Immediate-Early Proteins; Interferon-gamma; Multienzyme Complexes; Nuclear Proteins; Oligonucleotides; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Recombinant Proteins; Serpins; Signal Transduction; STAT1 Transcription Factor; Staurosporine; Trans-Activators; Tumor Cells, Cultured; Ubiquitin; Vanadates | 2002 |
Aggresome-related biogenesis of Lewy bodies.
Topics: Acetylcysteine; Antigens; Brain; Canavanine; Centrosome; Dose-Response Relationship, Drug; Golgi Apparatus; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Lewy Bodies; Lewy Body Disease; Nerve Tissue Proteins; Neurons; Parkinson Disease; Peptide Hydrolases; Protein Folding; Synucleins; Tubulin; Ubiquitins | 2002 |
Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques.
Topics: Acetylcysteine; Animals; Antibodies, Viral; Antigen Presentation; Antigen-Antibody Complex; CD4-Positive T-Lymphocytes; Epitopes, T-Lymphocyte; Gene Products, gag; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Macaca mulatta; Receptors, Fc; Simian Acquired Immunodeficiency Syndrome; T-Lymphocytes, Cytotoxic | 2003 |
c-Jun N-terminal kinase pathway mediates Lactacystin-induced cell death in a neuronal differentiated Neuro2a cell line.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Caspase 3; Caspase Inhibitors; Caspases; Cell Death; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neurons; p38 Mitogen-Activated Protein Kinases; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2002 |
Nitric oxide induces neutral ceramidase degradation by the ubiquitin/proteasome complex in renal mesangial cell cultures.
Topics: Acetylcysteine; Amidohydrolases; Animals; Blotting, Western; Cells, Cultured; Ceramidases; Ceramides; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Glomerular Mesangium; Kidney; Lipid Metabolism; Multienzyme Complexes; Neutral Ceramidase; Nitric Oxide; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Time Factors; Ubiquitin | 2002 |
Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation.
Topics: Acetylcysteine; Base Sequence; Cell Division; Curcumin; Cyclin D1; Cyclin D2; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; DNA Primers; Down-Regulation; Humans; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Mas; Proto-Oncogene Proteins; Retinoblastoma Protein; RNA, Messenger; Tumor Cells, Cultured | 2002 |
Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation.
Topics: Acetylcysteine; Animals; Cell Nucleus; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Gene Expression; Homeodomain Proteins; Humans; Insulin; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; RNA, Double-Stranded; SUMO-1 Protein; Trans-Activators; Transcription, Genetic | 2003 |
CXCR4 heterogeneity in primary cells: possible role of ubiquitination.
Topics: Acetylcysteine; Genetic Heterogeneity; Humans; Jurkat Cells; Lymphocytes; Macrophages; Molecular Weight; Monocytes; Precipitin Tests; Protein Isoforms; Protein Transport; Receptors, CXCR4; Ubiquitins | 2002 |
Effects of proteasome inhibitor (lactacystin) and cysteine protease inhibitor (E-64-d) on processes of mitosis in Xenopus embryonic cells.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Leucine; Mitosis; Signal Transduction; Xenopus | 2002 |
Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus.
Topics: Acetylcysteine; Blotting, Northern; Blotting, Western; BRCA1 Protein; Cell Cycle; Cell Division; Cell Survival; Collagen; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Combinations; Enzyme Inhibitors; Extracellular Matrix; Genetic Vectors; Germ-Line Mutation; Humans; Immunoblotting; Laminin; Leupeptins; MAP Kinase Signaling System; Neuregulin-1; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Polylysine; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteoglycans; Proto-Oncogene Proteins; Receptor, ErbB-2; RNA; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism.
Topics: Acetylcysteine; Animals; Antibodies; Blotting, Western; Caenorhabditis elegans Proteins; Carbazoles; Carrier Proteins; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Drosophila; Drosophila Proteins; Drug Interactions; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Helminth Proteins; Horseradish Peroxidase; Immunohistochemistry; Indoles; Insect Proteins; Maleimides; Microscopy, Confocal; Multienzyme Complexes; Mutation; Neomycin; Neuromuscular Junction; Oligopeptides; Phorbol Esters; Phospholipid Ethers; Presynaptic Terminals; Proteasome Endopeptidase Complex; Pyrroles; Pyrrolidinones; Synapses; Tumor Suppressor Proteins; Type C Phospholipases | 2003 |
Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Breast Neoplasms; Butadienes; Cell Nucleus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoplasm; Epidermal Growth Factor; Fatty Acids, Unsaturated; Humans; Ligands; Mitogen-Activated Protein Kinase Kinases; Multienzyme Complexes; Mutation; Nitriles; Phosphorylation; Promegestone; Proteasome Endopeptidase Complex; Receptors, Progesterone; Serine; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Short and versatile route to a key intermediate for lactacystin synthesis.
Topics: Acetylcysteine; Acylation; Alkylation; Cyclization; Glutamic Acid; Molecular Structure | 2003 |
NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Arsenicals; Cell Hypoxia; Cysteine Endopeptidases; Down-Regulation; Lactams; Mice; Multienzyme Complexes; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Proteasome Endopeptidase Complex; Radiation Tolerance; Tumor Cells, Cultured | 2003 |
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
Topics: Acetylcysteine; Benzoquinones; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Gene Expression; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Leupeptins; Ligases; Male; Molecular Chaperones; Multienzyme Complexes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Quinones; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids.
Topics: Acetylcysteine; Amino Acid Substitution; Antiviral Agents; Binding Sites; Capsid; DNA Replication; DNA, Viral; Half-Life; Hepatitis B virus; Hepatitis B Virus, Duck; Humans; Mutation; Nucleocapsid; Pyridines; Pyrimidines; Recombinant Proteins; Stereoisomerism; Triazoles; Tumor Cells, Cultured; Viral Core Proteins; Virus Assembly; Virus Replication | 2003 |
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Animals; Apoptosis; CDC2-CDC28 Kinases; Cell Cycle; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinases; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Flavonoids; Inclusion Bodies; Multienzyme Complexes; Neurons; Piperidines; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Rats; Retinoblastoma Protein; Ubiquitin | 2003 |
Early degradation of paternal mitochondria in domestic pig (Sus scrofa) is prevented by selective proteasomal inhibitors lactacystin and MG132.
Topics: Acetylcysteine; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Fertilization in Vitro; Fluorescent Antibody Technique; In Vitro Techniques; Leupeptins; Male; Microscopy, Electron; Mitochondria; Mitosis; Multienzyme Complexes; Ovum; Pregnancy; Proteasome Endopeptidase Complex; Sperm Maturation; Spermatozoa; Swine; Ubiquitin; Zygote | 2003 |
Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells.
Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Enzyme Inhibitors; Fluorescent Antibody Technique; Hydrogen-Ion Concentration; Membrane Potentials; Microscopy, Electron; Mitochondria; Multienzyme Complexes; Oligomycins; Pigment Epithelium of Eye; Poly Adenosine Diphosphate Ribose; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats | 2003 |
Fusion with HDEL protects cell wall invertase from early degradation when N-glycosylation is inhibited.
Topics: Acetylcysteine; beta-Fructofuranosidase; Biological Transport; Cell Wall; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycoproteins; Glycoside Hydrolases; Glycosylation; Golgi Apparatus; Plant Proteins; Plants; Protein Transport; Receptors, Peptide; Tunicamycin | 2003 |
EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin.
Topics: Acetylcysteine; alpha 1-Antitrypsin; Calnexin; Calreticulin; Cell Line; Endoplasmic Reticulum; Glycoproteins; Humans; Indolizines; Membrane Proteins; Precipitin Tests; Protein Binding; Protein Conformation; Protein Folding; Protein Transport; Recombinant Fusion Proteins; Transfection | 2003 |
NF-kappa B is required for surface Ig-induced Fas resistance in B cells.
Topics: Acetylcysteine; Animals; Antibodies, Anti-Idiotypic; Apoptosis; B-Lymphocyte Subsets; bcl-X Protein; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Cells, Cultured; fas Receptor; Gene Products, tat; HIV; I-kappa B Proteins; Immunoglobulin M; Immunosuppressive Agents; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; NF-kappa B; NF-KappaB Inhibitor alpha; Proto-Oncogene Proteins c-bcl-2; Pyrrolidines; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; tat Gene Products, Human Immunodeficiency Virus; Thiocarbamates | 2003 |
Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.
Topics: Acetylcysteine; Adenoviridae; Amino Acid Sequence; Animals; Cells, Cultured; Exocytosis; Humans; Insulin; Islets of Langerhans; Proinsulin; Rats; Secretory Vesicles | 2003 |
Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Line, Tumor; Chenodeoxycholic Acid; Cysteine Endopeptidases; DNA Fragmentation; Drug Synergism; Mastocytoma; Membrane Potentials; Mice; Mitochondria; Multienzyme Complexes; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex | 2003 |
Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Proteins | 2003 |
Calpain is involved in the HIV replication from the latently infected OM10.1 cells.
Topics: Acetylcysteine; Binding Sites; Calcimycin; Calcium Signaling; Calcium-Binding Proteins; Calpain; Cell Line; Glycoproteins; HIV-1; Humans; I-kappa B Proteins; In Vitro Techniques; Ionophores; Leucine; NF-kappa B; NF-KappaB Inhibitor alpha; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Virus Replication | 2003 |
Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates.
Topics: Acetylcysteine; Animals; Cell Line; Chromatography, Gel; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Mice; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Substrate Specificity; Ubiquitin | 2003 |
Relationship between beta-amyloid degradation and the 26S proteasome in neural cells.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Astrocytes; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunohistochemistry; Ligases; Macromolecular Substances; Neurons; Peptide Fragments; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Endosomal dynamics of Met determine signaling output.
Topics: Acetylcysteine; Cell Line; Cysteine Endopeptidases; Endosomal Sorting Complexes Required for Transport; Endosomes; HeLa Cells; Hepatocyte Growth Factor; Humans; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-met; Signal Transduction; Ubiquitin | 2003 |
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.
Topics: Acetylcysteine; Animals; Antibody Specificity; Cell Cycle; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytoplasm; Dual-Specificity Phosphatases; Electrophoresis, Polyacrylamide Gel; Humans; Mitosis; Mutagenesis, Site-Directed; NAD; Oligopeptides; Peptide Hydrolases; Phosphoric Monoester Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Tyrosine Phosphatases; Rabbits; Sirtuin 2; Sirtuins; Transfection; Ubiquitin | 2003 |
p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Breast; Breast Neoplasms; Carrier Proteins; Cells, Cultured; Computer Systems; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Leupeptins; Multienzyme Complexes; Neoplasm Proteins; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteins; Proto-Oncogene Proteins c-ets; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sequestosome-1 Protein; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Differential regulation of proteasome-dependent estrogen receptor alpha and beta turnover in cultured human uterine artery endothelial cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Antibody Specificity; Arteries; Blotting, Western; Cell Nucleus; Cell-Free System; Cells, Cultured; Cycloheximide; Cysteine Endopeptidases; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Humans; Insulin; Kinetics; Multienzyme Complexes; Proteasome Endopeptidase Complex; Puromycin; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Uterus | 2003 |
Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism.
Topics: Acetylcysteine; Animals; Cell Death; Clone Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disulfides; Hydrogen Peroxide; Lactones; Liver; Multienzyme Complexes; Oligopeptides; Oxidants; Oxidative Stress; Oxygen; Proteasome Endopeptidase Complex; Proteins; Rats; Solubility; Sulfones | 2003 |
Enhancement of endoplasmic reticulum (ER) degradation of misfolded Null Hong Kong alpha1-antitrypsin by human ER mannosidase I.
Topics: Acetylcysteine; Alkaloids; alpha 1-Antitrypsin; Blotting, Western; Cell Line; Endoplasmic Reticulum; Glycoproteins; Humans; Mannosidases; Oligonucleotides; Oligosaccharides; Plasmids; Precipitin Tests; Protein Binding; Protein Folding; Time Factors; Transfection | 2003 |
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Benzoquinones; Breast Neoplasms; Carrier Proteins; Cysteine Endopeptidases; Enzyme Inhibitors; Gene Deletion; Gene Expression; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunosorbent Techniques; Lactams, Macrocyclic; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinones; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Identification of small PDZK1-associated protein, DD96/MAP17, as a regulator of PDZK1 and plasma high density lipoprotein levels.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; CD36 Antigens; Cholesterol, HDL; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Humans; Liver; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Molecular Sequence Data; Multienzyme Complexes; Neoplasm Proteins; Proteasome Endopeptidase Complex; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, Scavenger; Scavenger Receptors, Class B; Transfection | 2003 |
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Topics: Acetylcysteine; Adult; Aged; alpha-Synuclein; Amino Acid Sequence; Carrier Proteins; Case-Control Studies; Cell Death; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Green Fluorescent Proteins; Humans; Luminescent Proteins; Male; Middle Aged; Molecular Sequence Data; Multienzyme Complexes; Mutation; Nerve Tissue Proteins; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Staurosporine; Synucleins; Ubiquitin-Protein Ligases | 2003 |
Lactacystin augments the sulindac-induced apoptosis in HT-29 cells.
Topics: Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Carcinoma; Cell Line, Tumor; Colonic Neoplasms; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Synergism; HT29 Cells; Humans; Multienzyme Complexes; Proteasome Endopeptidase Complex; Reaction Time; Sulindac | 2003 |
Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Breast Neoplasms; Brefeldin A; Cell Communication; Cell Membrane; Connexin 43; Cycloheximide; Cysteine Endopeptidases; Gap Junctions; Humans; Immunohistochemistry; Lysosomes; Mammary Neoplasms, Animal; Microscopy, Confocal; Microscopy, Electron; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Protein Transport; Rats; Signal Transduction; Time Factors; Tumor Cells, Cultured | 2003 |
Troglitazone reduces heat shock protein 70 content in primary rat hepatocytes by a ubiquitin proteasome independent mechanism.
Topics: Acetylcysteine; Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromans; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gene Expression; Heat-Shock Proteins; Hepatocytes; Histones; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazolidinediones; Troglitazone; Ubiquitin | 2003 |
The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription.
Topics: Acetylcysteine; Animals; Apolipoproteins E; Avian Proteins; beta-Galactosidase; Blotting, Western; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Nucleus; COS Cells; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Luciferases; Membrane Proteins; Microscopy, Fluorescence; Models, Biological; Multienzyme Complexes; Neoplasm Proteins; Nerve Tissue Proteins; Nuclear Proteins; Promoter Regions, Genetic; Promyelocytic Leukemia Protein; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Suppressor Proteins | 2003 |
A proteasome inhibitor reduces concurrent, sequential, and long-term IL-1 beta- and TNF-alpha-induced ECAM expression and adhesion.
Topics: Acetylcysteine; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Resistance; E-Selectin; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; Multienzyme Complexes; Myeloid Cells; Proteasome Endopeptidase Complex; Time Factors; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2003 |
Inhibition of the proteasome by lactacystin enhances oligodendroglial cell differentiation.
Topics: Acetylcysteine; Animals; Bromodeoxyuridine; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Immunohistochemistry; Leupeptins; Macromolecular Substances; Oligodendroglia; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Signal Transduction | 2003 |
Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation.
Topics: Acetylcysteine; Albumins; alpha 1-Antitrypsin; Amino Acid Sequence; Animals; Carbohydrate Sequence; Endoplasmic Reticulum, Smooth; Enzyme Inhibitors; Exocytosis; Glycoproteins; Glycosylation; Liver Neoplasms, Experimental; Mannans; Mannosidases; Mice; Models, Chemical; Molecular Sequence Data; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Stochastic Processes; Structure-Activity Relationship; Substrate Specificity; Transfection; Transferrin; Tumor Cells, Cultured | 2003 |
Imaging 26S proteasome activity and inhibition in living mice.
Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Coleoptera; Cysteine Proteinase Inhibitors; Genes, Reporter; HeLa Cells; Humans; Kinetics; Leupeptins; Luciferases; Luminescent Measurements; Male; Mice; Mice, Nude; Molecular Biology; Peptide Hydrolases; Proteasome Endopeptidase Complex; Pyrazines; Transfection; Ubiquitin; Xenograft Model Antitumor Assays | 2003 |
Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.
Topics: Acetylcysteine; Acids; Alleles; Amino Acid Sequence; Aspartic Acid Endopeptidases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Epitopes; Flow Cytometry; Histocompatibility Antigens Class I; HLA Antigens; HLA-E Antigens; HLA-G Antigens; Humans; Ligands; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Peptides; Plasmids; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Structure, Tertiary; Serine Endopeptidases; Transcription, Genetic; Transfection | 2003 |
Myogenic differentiation of Drosophila Schneider cells by DNA double-strand break-inducing drugs.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cysteine Proteinase Inhibitors; DNA Damage; Drosophila; Ecdysterone; Fluorescent Dyes; Indoles; Microscopy, Phase-Contrast; Muscle Cells; Myosin Heavy Chains; Nucleic Acid Synthesis Inhibitors; Oxidative Stress; Signal Transduction; Zinostatin | 2003 |
Inhibition of the proteasome induces cell cycle arrest and apoptosis in mantle cell lymphoma cells.
Topics: Acetylcysteine; Apoptosis; B-Lymphocytes; Blotting, Western; Caspase 3; Caspase 9; Caspases; CD4-Positive T-Lymphocytes; Cell Cycle; Humans; In Situ Nick-End Labeling; Lymphoma, Mantle-Cell; Protease Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Human platelet 20S proteasome: inhibition of its chymotrypsin-like activity and identification of the proteasome activator PA28. A preliminary report.
Topics: Acetylcysteine; Blood Platelets; Chymotrypsin; Coumarins; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Multienzyme Complexes; Oligopeptides; Proteasome Endopeptidase Complex | 2003 |
CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.
Topics: Acetylcysteine; Adenoviridae; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Lineage; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinases; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; HeLa Cells; Humans; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; RNA Interference; S-Phase Kinase-Associated Proteins; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Cytochromes c; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leupeptins; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Multienzyme Complexes; Osteosarcoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Retinoblastoma Protein; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2003 |
Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination.
Topics: Acetylcysteine; Apoptosis; Arginine; Caspase 3; Caspases; Cell Line, Transformed; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Precursors; HL-60 Cells; Humans; Lysine; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Subunits; Proteins; Transfection; Ubiquitin; X-Linked Inhibitor of Apoptosis Protein | 2003 |
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins.
Topics: Acetylcysteine; alpha-Synuclein; Cell Line; Cell Survival; Cysteine Endopeptidases; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Ligases; Macromolecular Substances; Multienzyme Complexes; Nerve Tissue Proteins; Neurofilament Proteins; Nitrates; Nitric Oxide Synthase; Proteasome Endopeptidase Complex; Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Synucleins; Tubulin; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling events.
Topics: Acetylcysteine; Acute-Phase Proteins; Animals; Carrier Proteins; Cell Line; Chymotrypsin; Cross-Linking Reagents; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Down-Regulation; Enzyme Activation; Escherichia coli; Glutamate Synthase; Leupeptins; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Membrane Glycoproteins; Membrane Proteins; Methanosarcina; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Phosphorylation; Proteasome Endopeptidase Complex; Shock, Septic; Signal Transduction; Tritium | 2003 |
Oxidative-stress-induced T lymphocyte hyporesponsiveness is caused by structural modification rather than proteasomal degradation of crucial TCR signaling molecules.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Carrier Proteins; Coculture Techniques; Cysteine Endopeptidases; Humans; Immune Tolerance; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Membrane Proteins; Multienzyme Complexes; Neutrophils; Oxidative Stress; Phosphoproteins; Proteasome Endopeptidase Complex; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Signal Transduction; T-Lymphocytes | 2003 |
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspases; Cysteine Endopeptidases; Diamines; Electrophoresis, Gel, Two-Dimensional; Enzyme Activation; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukemia, Megakaryoblastic, Acute; Leupeptins; Lysine; Multienzyme Complexes; Oligodeoxyribonucleotides, Antisense; Peptide Initiation Factors; Peptide Mapping; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteomics; RNA-Binding Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Subcellular Fractions; Tumor Cells, Cultured; Ubiquitin | 2003 |
Evidence for proteasome dysfunction in cytotoxicity mediated by anti-Ras intracellular antibodies.
Topics: 3T3 Cells; Acetylcysteine; Animals; Antibodies; Apoptosis; Cell Division; Cysteine Endopeptidases; Humans; Immunoglobulin Fragments; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; ras Proteins | 2003 |
Parkin is recruited to the centrosome in response to inhibition of proteasomes.
Topics: 3T3 Cells; Acetylcysteine; Animals; Brain; Centrosome; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Immunohistochemistry; Mice; Microtubules; Multienzyme Complexes; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Binding; Protein Denaturation; Protein Folding; Rats; Tubulin; Ubiquitin-Protein Ligases; Ubiquitins | 2003 |
Proteasome is required for class I-restricted presentation by Fcgamma receptor-mediated endocytosis in primary biliary cirrhosis.
Topics: Acetylcysteine; Antigen Presentation; Cysteine Endopeptidases; Dendritic Cells; Dihydrolipoyllysine-Residue Acetyltransferase; Endocytosis; Histocompatibility Antigens Class I; Humans; Liver Cirrhosis, Biliary; Multienzyme Complexes; Peptide Fragments; Proteasome Endopeptidase Complex; Pyruvate Dehydrogenase Complex; Receptors, IgG; Signal Transduction; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic | 2003 |
Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Survival; COS Cells; Cysteine Endopeptidases; Cytoplasm; Heat-Shock Proteins; HeLa Cells; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Molecular Chaperones; Multienzyme Complexes; Muscular Dystrophy, Oculopharyngeal; Neurodegenerative Diseases; Peptides; Plasmids; Proteasome Endopeptidase Complex; Protein Conformation; Time Factors; Transfection; Ubiquitin | 2003 |
A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Cell Line; Cysteine Proteinase Inhibitors; Deferoxamine; Humans; Iron; Iron Chelating Agents; Iron Regulatory Protein 1; Leupeptins; Mice; Molecular Sequence Data; Mutation; Point Mutation; Recombinant Proteins; Sequence Homology, Amino Acid; Serine | 2003 |
Cell cycle- and activation-dependent regulation of cyclosporin A-induced T cell apoptosis.
Topics: Acetylcysteine; Apoptosis; Cell Cycle; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Immunosuppressive Agents; Jurkat Cells; Lymphocyte Activation; Multienzyme Complexes; Proteasome Endopeptidase Complex; T-Lymphocytes | 2003 |
Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Cell Death; Corpus Striatum; Cysteine Endopeptidases; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inclusion Bodies; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Multienzyme Complexes; Nerve Tissue Proteins; Oligopeptides; PC12 Cells; Pheochromocytoma; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase | 2003 |
The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid beta-protein generation.
Topics: Acetylcysteine; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Cell Line; Cells, Cultured; Endoplasmic Reticulum; Fibroblasts; Humans; Membrane Proteins; Mice; Peptide Fragments; Protein Structure, Tertiary; Sequence Deletion; Time Factors; Transfection; Ubiquitin | 2003 |
Effect of ubiquitin-proteasome pathway on mouse blastocyst implantation and expression of matrix metalloproteinases-2 and -9.
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Embryo Implantation; Female; Gene Expression Regulation, Enzymologic; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Multienzyme Complexes; Pregnancy; Proteasome Endopeptidase Complex; Rabbits; RNA, Messenger; Ubiquitin | 2004 |
The mechanism of alphaB-crystallin gene expression by proteasome inhibition.
Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Heat-Shock Response; Leupeptins; Multienzyme Complexes; Myocytes, Cardiac; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Rats | 2003 |
Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes.
Topics: Acetylcysteine; Apoptosis; Cell Death; Cell Line, Tumor; Chemotaxis, Leukocyte; Cysteine Proteinase Inhibitors; DNA; DNA Fragmentation; Enzyme Activation; Fetus; Hepatocytes; Humans; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Peptide Hydrolases; Proteasome Endopeptidase Complex; RNA, Messenger; Transcription Factor AP-1; Up-Regulation | 2003 |
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins | 2003 |
Adenovirus E4-34kDa requires active proteasomes to promote late gene expression.
Topics: Acetylcysteine; Adenovirus E4 Proteins; Adenoviruses, Human; Animals; Cell Line; Chlorocebus aethiops; Gene Expression Regulation, Viral; Genetic Complementation Test; HeLa Cells; Humans; Mutation; Peptide Hydrolases; Proteasome Endopeptidase Complex; Virus Replication | 2003 |
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
Topics: Acetylcysteine; Adherens Junctions; Animals; Blotting, Northern; Bromodeoxyuridine; Cell Adhesion; Cell Differentiation; Cell Division; Cell Line; Claudin-1; Claudin-3; Claudin-4; Claudins; Cycloheximide; Detergents; Dogs; Epithelium; ErbB Receptors; Gene Expression Regulation; Hepatocyte Growth Factor; Immunoblotting; Kidney; Membrane Proteins; Microscopy, Fluorescence; Neoplasms; Octoxynol; Phenotype; Protein Synthesis Inhibitors; Signal Transduction; Tight Junctions; Time Factors | 2004 |
Both insulin resistance and diabetes in Psammomys obesus upregulate the hepatic machinery involved in intracellular VLDL assembly.
Topics: Acetylcysteine; Animals; Apolipoproteins B; Cells, Cultured; Cysteine Endopeptidases; Diabetes Mellitus; Disease Models, Animal; Gerbillinae; Hepatocytes; Hypercholesterolemia; Hyperinsulinism; Hypertriglyceridemia; Insulin; Insulin Resistance; Leupeptins; Lipoproteins, VLDL; Liver; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex | 2004 |
The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells.
Topics: Acetylcysteine; Adenosine Triphosphatases; Animals; Cell Line; Cell Nucleus; Endocytosis; Endosomal Sorting Complexes Required for Transport; Endosomes; Flow Cytometry; Genes, Dominant; Green Fluorescent Proteins; Hemagglutinins; Hydrogen-Ion Concentration; Leupeptins; Luminescent Proteins; Microscopy, Fluorescence; Mink; Orthomyxoviridae; Plasmids; Protein Transport; Receptor, IGF Type 2; Retroviridae; Saccharomyces cerevisiae Proteins; Time Factors; Transfection; Ubiquitin; Vesicular stomatitis Indiana virus; Virus Replication | 2003 |
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Calcium; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Disks Large Homolog 4 Protein; Drug Interactions; Electric Stimulation; Embryo, Mammalian; Endocytosis; Epitopes; Excitatory Amino Acid Agonists; Hippocampus; Humans; Immunoglobulin G; Immunohistochemistry; Immunosuppressive Agents; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Kidney; Leupeptins; Membrane Potentials; Membrane Proteins; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Neural Inhibition; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Long-Evans; Receptors, AMPA; Synapses; Synapsins; Tacrolimus; Time Factors; Transfection; Ubiquitin | 2003 |
Proteasome inhibition arrests neurite outgrowth and causes "dying-back" degeneration in primary culture.
Topics: Acetylcysteine; Animals; Cell Division; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Growth Inhibitors; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Nerve Degeneration; Neural Inhibition; Neurites; PC12 Cells; Proteasome Endopeptidase Complex; Rats | 2003 |
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; alpha-Synuclein; Animals; Brain; Caspase 3; Caspase Inhibitors; Caspases; Cysteine Endopeptidases; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Herbicides; Immunoblotting; Immunohistochemistry; Ions; L-Lactate Dehydrogenase; Leupeptins; Male; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nerve Tissue Proteins; Neurons; Phosphorylation; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Rotenone; Synucleins; Time Factors; Ubiquitin | 2004 |
Interferon-gamma induces apoptosis of lens alphaTN4-1 cells and proteasome inhibition has an antiapoptotic effect.
Topics: Acetylcysteine; Animals; Annexin A5; Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoprotection; DNA-Binding Proteins; Epithelial Cells; Interferon Regulatory Factor-1; Interferon Regulatory Factors; Interferon-gamma; Lens, Crystalline; Leupeptins; Mice; Multienzyme Complexes; Phosphoproteins; Proteasome Endopeptidase Complex; Recombinant Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor; Trans-Activators; Up-Regulation | 2004 |
A novel gene mutation in the 60s loop of human coagulation factor VII - inhibition of interdomain crosstalk.
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Brain; Brefeldin A; CHO Cells; Circular Dichroism; Cricetinae; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Precursors; Exons; Factor VII; Factor X; Factor Xa; Heterozygote; Humans; Inhibitory Concentration 50; Kinetics; Models, Molecular; Mutation; Peptides; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Recombinant Proteins; Restriction Mapping; Sequence Analysis, DNA; Serine Endopeptidases; Surface Plasmon Resonance; Time Factors; Transfection | 2004 |
A new structural class of proteasome inhibitors identified by microbial screening using yeast-based assay.
Topics: Acetylcysteine; CDC28 Protein Kinase, S cerevisiae; Cell Cycle; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Dipeptides; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Lactones; Multienzyme Complexes; Peptides; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Ubiquitin | 2004 |
Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcysteine; Adenylyl Cyclase Inhibitors; Animals; Cell Differentiation; Cell Survival; Cyclic AMP; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Fibroblasts; Leupeptins; Mice; Multienzyme Complexes; Neuroblastoma; Phosphodiesterase Inhibitors; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 2004 |
Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1.
Topics: Acetylcysteine; Amino Acid Motifs; Amino Acid Sequence; Cell Line; Cell Membrane; Chloroquine; Dimerization; DNA, Complementary; Electrophysiology; Endocytosis; Epitopes; Humans; Immunoblotting; Intermediate-Conductance Calcium-Activated Potassium Channels; Leucine; Leucine Zippers; Lysosomes; Microscopy, Fluorescence; Molecular Sequence Data; Mutation; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Calcium-Activated; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Protein Transport; Temperature; Time Factors | 2004 |
The inhibitory role of lactacystin and beta-lactacystin on T-cell activation and proliferation.
Topics: Acetylcysteine; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Division; Cysteine Proteinase Inhibitors; Down-Regulation; Flow Cytometry; Humans; Interleukin-2; Lectins, C-Type; Leukocytes, Mononuclear; Lymphocyte Activation; Muscle Proteins; Proteasome Endopeptidase Complex; Proteins; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Time Factors | 2004 |
DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function.
Topics: Acetylcysteine; Adolescent; Adult; Age of Onset; Amino Acid Sequence; Animals; Cell Line; DNA Mutational Analysis; Female; Genes, Recessive; Humans; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Molecular Sequence Data; Mutation; Oncogene Proteins; Parkinsonian Disorders; Protein Deglycase DJ-1; RNA, Messenger | 2004 |
[Effect of EGF on ubiquitination and proteasome-dependent degradation of phospholipase C gamma1 in A431 cells].
Topics: Acetylcysteine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; Epithelial Cells; Humans; Leupeptins; Multienzyme Complexes; Phospholipase C gamma; Proteasome Endopeptidase Complex; Type C Phospholipases; Ubiquitins | 2003 |
Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway.
Topics: Acetylcysteine; Animals; CHO Cells; Cricetinae; Endoplasmic Reticulum; Humans; Leupeptins; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Transport; Receptors, LDL | 2004 |
Degradation properties of polyglutamine-expanded human androgen receptor in transfected cells.
Topics: Acetylcysteine; Anti-Bacterial Agents; Blotting, Western; Cell Line; Cycloheximide; Cysteine Proteinase Inhibitors; Doxycycline; Drug Interactions; Embryo, Mammalian; Fluorescent Antibody Technique; Gene Expression; Humans; Kidney; Peptides; Protein Synthesis Inhibitors; Receptors, Androgen; Time Factors; Transfection | 2004 |
The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins.
Topics: Acetylcysteine; Animals; CHO Cells; Coat Protein Complex I; Cricetinae; Cricetulus; Electrophoretic Mobility Shift Assay; Endoplasmic Reticulum; Golgi Apparatus; Immunoprecipitation; Intracellular Membranes; Membrane Proteins; Microscopy, Fluorescence; Multiprotein Complexes; Mutation; Proteasome Endopeptidase Complex; Protein Binding; Protein Transport; RNA Interference; SNARE Proteins; Vesicular Transport Proteins | 2004 |
GSK3 beta-dependent phosphorylation of the alpha NAC coactivator regulates its nuclear translocation and proteasome-mediated degradation.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adenosine Triphosphate; Animals; Cell Nucleus; COS Cells; Cysteine Proteinase Inhibitors; Drug Synergism; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Isoenzymes; Molecular Chaperones; Mutagenesis, Site-Directed; Peptide Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; Substrate Specificity; Trans-Activators; Transfection | 2004 |
Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Insulin; Leucine; Molecular Sequence Data; Mutation; Proteins; Receptor Protein-Tyrosine Kinases; Receptor, Insulin; Transfection; Tyrosine | 2003 |
Influence of p53 and p21Waf1 expression on G2/M phase arrest of colorectal carcinoma HCT116 cells to proteasome inhibitors.
Topics: Acetylcysteine; Apoptosis; Butyrates; Caspases; Cell Division; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Therapy, Combination; G2 Phase; Humans; Leupeptins; Mitosis; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 2004 |
Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Blotting, Western; Cell Survival; Chelating Agents; Chlorides; Copper; Detergents; Disease Models, Animal; Ditiocarb; Fibroblasts; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Minocycline; Mutation; Oxidative Stress; Paraquat; Peroxynitrous Acid; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Solubility; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Zinc Compounds | 2004 |
The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a glycoprotein embedded in the endoplasmic reticulum membrane.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Calreticulin; COS Cells; Cysteine Endopeptidases; Diabetes Mellitus; Endoplasmic Reticulum; Enzyme Inhibitors; Glucose-6-Phosphatase; Glycoproteins; Humans; Membrane Proteins; Mice; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Structure, Secondary; Proteins; Recombinant Fusion Proteins | 2004 |
Alternative processing for MHC class I presentation by immature and CpG-activated dendritic cells.
Topics: Acetylcysteine; Animals; Antigen Presentation; Bone Marrow; Brefeldin A; Cells, Cultured; CpG Islands; Cysteine Proteinase Inhibitors; Dendritic Cells; Female; Flow Cytometry; Histocompatibility Antigens Class I; Mice; Ovalbumin; Protein Synthesis Inhibitors | 2004 |
Effect of ajoene, a natural antitumor small molecule, on human 20S proteasome activity in vitro and in human leukemic HL60 cells.
Topics: Acetylcysteine; Antineoplastic Agents; Cell Division; Chymotrypsin; Disulfides; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Garlic; HL-60 Cells; Humans; Hybridomas; Ovalbumin; Peptides; Plant Extracts; Plant Stems; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sulfoxides; Time Factors; Trypsin | 2004 |
Trastuzumab (Herceptin) enhances class I-restricted antigen presentation recognized by HER-2/neu-specific T cytotoxic lymphocytes.
Topics: Acetylcysteine; Annexin A5; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Coloring Agents; Cytotoxicity, Immunologic; Enzyme-Linked Immunosorbent Assay; Epitopes; Flow Cytometry; Genes, MHC Class I; Histocompatibility Antigens Class I; Humans; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptor, ErbB-2; T-Lymphocytes, Cytotoxic; Trastuzumab | 2004 |
An efficient synthesis of lactacystin beta-lactone.
Topics: Acetylcysteine; Lactones; Ruthenium | 2004 |
Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.
Topics: Acetylcysteine; Anticarcinogenic Agents; Apoptosis; bcl-X Protein; Caspases; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cysteine Proteinase Inhibitors; G2 Phase; Gene Expression Regulation; Humans; Isothiocyanates; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Transfection | 2004 |
Transcriptional repression of E2F gene by proteasome inhibitors in human osteosarcoma cells.
Topics: Acetylcysteine; Antioxidants; Cell Cycle Proteins; Cell Line, Tumor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Down-Regulation; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; Glutathione; Humans; Leupeptins; Multienzyme Complexes; Osteosarcoma; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
CD8+ T cell cross-priming via transfer of proteasome substrates.
Topics: Acetylcysteine; Animals; Antigen Presentation; Antigens; Antigens, Viral; CD8-Positive T-Lymphocytes; Cell Line; Cross-Priming; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Immunization; Influenza A virus; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Chaperones; Multienzyme Complexes; Ovalbumin; Peptide Fragments; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Vaccines; Vaccinia virus | 2004 |
Distinct effects of the antiestrogen Faslodex on the stability of estrogen receptors-alpha and -beta in the breast cancer cell line MCF-7.
Topics: Acetylcysteine; Animals; Breast Neoplasms; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fulvestrant; Gene Expression Regulation; Genes, Reporter; Humans; Ligands; Point Mutation; Tamoxifen | 2004 |
Long term proteasome inhibition does not preferentially afflict motor neurons in organotypical spinal cord cultures.
Topics: Acetylcysteine; Activating Transcription Factor 3; Animals; Cell Count; Cell Survival; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Immunohistochemistry; Interneurons; Mice; Mice, Transgenic; Motor Neurons; Neurofilament Proteins; Oligopeptides; Organ Culture Techniques; Protease Inhibitors; Spinal Cord; Superoxide Dismutase; Time Factors; Transcription Factors; Ubiquitin | 2004 |
Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture.
Topics: Acetylcysteine; alpha-Crystallin B Chain; Animals; Apoptosis; Brain; Cells, Cultured; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Inclusion Bodies; Leupeptins; Microtubules; Oligodendroglia; Oxidative Stress; Phosphorylation; Proteasome Inhibitors; Rats; Rats, Wistar; RNA, Messenger; tau Proteins; Ubiquitin | 2004 |
The Icelandic founder mutation BRCA2 999del5: analysis of expression.
Topics: Acetylcysteine; Animals; BRCA2 Protein; Cell Line; Cells, Cultured; Chlorocebus aethiops; COS Cells; Cysteine Endopeptidases; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Founder Effect; Gene Expression Regulation, Neoplastic; Genes, BRCA2; Heterozygote; Humans; Iceland; Molecular Weight; Multienzyme Complexes; Mutation; Proteasome Endopeptidase Complex; RNA, Messenger; RNA, Neoplasm; Sequence Deletion; Transcription Factors | 2004 |
The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.
Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Leishmania; Leishmaniasis, Visceral; Leucine; Macrophages, Peritoneal; Male; Mice; Multienzyme Complexes; Oligopeptides; Phenylmethylsulfonyl Fluoride; Proteasome Endopeptidase Complex | 2004 |
Nestin expression is lost in a neural stem cell line through a mechanism involving the proteasome and Notch signalling.
Topics: Acetylcysteine; Animals; Cell Count; Cell Differentiation; Cell Line; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cricetinae; Cricetulus; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Embryo, Mammalian; Fluorescent Dyes; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Hippocampus; Immunohistochemistry; Intermediate Filament Proteins; Luminescent Proteins; Male; Membrane Proteins; Mice; Multienzyme Complexes; Nerve Tissue Proteins; Nestin; Neuroglia; Neurons; Organic Chemicals; Phosphopyruvate Hydratase; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Receptors, Notch; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stem Cell Transplantation; Stem Cells; Temperature; Time Factors; Transfection | 2004 |
Proteasomal interference prevents zona pellucida penetration and fertilization in mammals.
Topics: Acetylcysteine; Acrosome; Acrosome Reaction; Animals; Exocytosis; Female; Fertilization; Fertilization in Vitro; Immune Sera; Leupeptins; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sperm-Ovum Interactions; Spermatozoa; Swine; Ubiquitin; Zona Pellucida | 2004 |
p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-x(L).
Topics: Acetylcysteine; Apoptosis; bcl-X Protein; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Down-Regulation; Endothelial Cells; Enzyme Inhibitors; Humans; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reaction Time; Signal Transduction; Tumor Necrosis Factor-alpha | 2004 |
Degradation of BACE by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Line; Cell Line, Tumor; Endopeptidases; Humans; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Ubiquitin | 2004 |
Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Membrane; Cerebral Cortex; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Mice; Multienzyme Complexes; Neurons; Proteasome Endopeptidase Complex; Protein Tyrosine Phosphatases; PTEN Phosphohydrolase; Tumor Suppressor Proteins | 2004 |
Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.
Topics: Acetylcysteine; Animals; Arachidonic Acid; Breast Neoplasms; Cell Line; Cell Line, Tumor; HT29 Cells; Humans; Leupeptins; Liver; Neuroglia; Oligopeptides; Proteasome Inhibitors; Rats | 2004 |
alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Benzothiazoles; Blotting, Western; Cells, Cultured; Cytoplasm; Genotype; Lewy Bodies; Mice; Mice, Knockout; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Protease Inhibitors; Proteasome Inhibitors; Rats; Synucleins; Thiazoles; Time Factors; Ubiquitin | 2004 |
Resistance of the human beta1-adrenergic receptor to agonist-induced ubiquitination: a mechanism for impaired receptor degradation.
Topics: Acetylcysteine; Animals; Arrestin; Cell Line; Cricetinae; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endocytosis; Humans; Lysosomes; Microscopy, Confocal; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Time Factors; Transfection; Ubiquitin | 2004 |
Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Blotting, Western; Carrier Proteins; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ganglia, Sympathetic; Genes, bcl-2; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins; Membrane Proteins; Mice; Mice, Knockout; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rhodamines; Signal Transduction; Time Factors; Ubiquitin | 2004 |
cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcysteine; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Colforsin; COS Cells; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Genetic Vectors; Immunoprecipitation; Leupeptins; Luciferases; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Nuclear Receptor Coactivator 2; Protease Inhibitors; Proteasome Endopeptidase Complex; Temperature; Thionucleotides; Time Factors; Transcriptional Activation; Transfection; Ubiquitin | 2004 |
Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathology.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aged; Aged, 80 and over; Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Dopamine; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Lewy Bodies; Male; Middle Aged; Neuroblastoma; Nuclear Proteins; Parkinsonian Disorders; Postmortem Changes; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tretinoin | 2004 |
Acute exercise alters Galphai2 protein expressions through the ubiquitin-proteasome proteolysis pathway in rat adipocytes.
Topics: Acetylcysteine; Adaptation, Physiological; Adipocytes; Animals; Cells, Cultured; Enzyme Activation; Gene Expression Regulation; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Male; Multienzyme Complexes; Peptide Hydrolases; Physical Conditioning, Animal; Physical Endurance; Propranolol; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Rats; Rats, Wistar; Signal Transduction; Ubiquitin | 2004 |
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
Topics: Acetylcysteine; Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Insulin; Insulin Receptor Substrate Proteins; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Rats; Receptor, Insulin; RNA, Small Interfering; Serine; Signal Transduction; Ubiquitin | 2004 |
Coordination of oxidized protein hydrolase and the proteasome in the clearance of cytotoxic denatured proteins.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; HSP70 Heat-Shock Proteins; Oligopeptides; Oxidation-Reduction; Oxidative Stress; Paraquat; Peptide Hydrolases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Denaturation; Tubulin; Vimentin | 2004 |
Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Blotting, Western; Cell Line; COS Cells; Cysteine Proteinase Inhibitors; Detergents; DNA, Complementary; Dose-Response Relationship, Drug; Glutathione Transferase; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunoglobulin G; Immunoprecipitation; Lactones; Macrolides; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Palmitic Acids; Proteasome Inhibitors; Protein Structure, Tertiary; Rabbits; Rats; Time Factors; Transfection; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity.
Topics: Acetylcysteine; beta Catenin; Cell Line; Cell Line, Tumor; Cytoskeletal Proteins; Cytosol; Down-Regulation; Endosomes; Enzyme Inhibitors; Green Fluorescent Proteins; HeLa Cells; Hepatocyte Growth Factor; Humans; Lysine; Lysosomes; Phosphorylation; Point Mutation; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Proto-Oncogene Proteins c-met; Recombinant Proteins; Time Factors; Trans-Activators; Transfection; Ubiquitin | 2004 |
Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Survival; Culture Media; Endopeptidases; Humans; Multienzyme Complexes; Neuroblastoma; Peptide Hydrolases; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2005 |
Inhibition of proteasome activity sensitizes dopamine neurons to protein alterations and oxidative stress.
Topics: Acetylcysteine; Animals; Canavanine; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Female; gamma-Aminobutyric Acid; Heat-Shock Response; Immunohistochemistry; Nerve Tissue Proteins; Neurons; Oxidative Stress; Parkinson Disease, Secondary; Pregnancy; Proteasome Inhibitors; Protein Folding; Rats; Rats, Sprague-Dawley | 2004 |
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells.
Topics: Acetylcysteine; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytokines; Disease Progression; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; Glomerular Mesangium; Humans; Immunohistochemistry; Indicators and Reagents; Inflammation Mediators; Interleukin-1; Lupus Nephritis; Matrix Metalloproteinase 7; Membrane Glycoproteins; Microscopy, Confocal; Microscopy, Electron; NF-kappa B; Nuclear Proteins; Up-Regulation | 2004 |
Regulation of nicotinic receptor expression by the ubiquitin-proteasome system.
Topics: Acetylcysteine; Animals; Bungarotoxins; Cell Line; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Mice; Muscle Fibers, Skeletal; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Subunits; Protein Transport; Radioligand Assay; Receptors, Nicotinic; Ubiquitin | 2004 |
Proteasomes act in the pre-mitochondrial signal transduction route towards roscovitine-induced apoptosis.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lung Neoplasms; Membrane Potentials; Mitochondria; Proteasome Endopeptidase Complex; Purines; Roscovitine; Signal Transduction; Tumor Cells, Cultured | 2004 |
A concise route to (+)-lactacystin.
Topics: Acetylcysteine; Carbamates; Catalysis; Molecular Structure; Proteasome Inhibitors; Stereoisomerism; Tromethamine | 2004 |
Probiotics inhibit nuclear factor-kappaB and induce heat shock proteins in colonic epithelial cells through proteasome inhibition.
Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Chemokine CCL2; Colon; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Intestinal Mucosa; Mice; NF-kappa B; Probiotics; Proteasome Endopeptidase Complex; Ubiquitin | 2004 |
Effect of proteasome pathway on initiation of mouse labor induced by antiprogesterone.
Topics: Abortifacient Agents, Steroidal; Acetylcysteine; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Electrophoretic Mobility Shift Assay; Female; Gene Expression Regulation; Interleukin-1; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Mifepristone; NF-kappa B; Parturition; Pregnancy; Prostaglandin-Endoperoxide Synthases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Oxytocin; Receptors, Prostaglandin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Uterus | 2004 |
[BAY11-7082 and Lactacystein in CD154-induced NF-kappaB activation].
Topics: Acetylcysteine; Apoptosis; Burkitt Lymphoma; CD40 Ligand; Cysteine Proteinase Inhibitors; Enzyme Activation; Humans; NF-kappa B; Nitriles; Sulfones; Tumor Cells, Cultured | 2004 |
Proteasome inhibitors suppress formation of polyglutamine-induced nuclear inclusions in cultured postmitotic neurons.
Topics: Acetylcysteine; Animals; Blotting, Western; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Count; Cell Size; Cells, Cultured; Cysteine Proteinase Inhibitors; Dendrites; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Hippocampus; HSP70 Heat-Shock Proteins; Immunohistochemistry; Intranuclear Inclusion Bodies; Mutagenesis; Neurons; Peptides; Phthalimides; Rats; Superior Cervical Ganglion; Time Factors; Transfection; Transforming Growth Factor beta | 2004 |
Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; fas Receptor; Gene Expression Regulation; I-kappa B Proteins; JNK Mitogen-Activated Protein Kinases; Luciferases; Male; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Recombinant Fusion Proteins; Sertoli Cells; Signal Transduction; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspases; Cell Survival; Complement Membrane Attack Complex; Complement System Proteins; Cysteine Proteinase Inhibitors; Cytochromes c; Gene Expression; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Leupeptins; Lymphocytes; Mitochondria; Mitochondrial Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA Interference | 2005 |
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Insulinoma; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Pancreatic Neoplasms; Proteasome Inhibitors; Rats; Signal Transduction; Tumor Suppressor Protein p53 | 2005 |
Filamin A binding stabilizes nascent glycoprotein Ibalpha trafficking and thereby enhances its surface expression.
Topics: Acetylcysteine; Animals; Brefeldin A; Cell Membrane; CHO Cells; Contractile Proteins; Cricetinae; Endoplasmic Reticulum; Filamins; Microfilament Proteins; Multiprotein Complexes; Platelet Glycoprotein GPIb-IX Complex; Protein Transport | 2005 |
Upregulation of clusterin/apolipoprotein J in lactacystin-treated SH-SY5Y cells.
Topics: Acetylcysteine; Analysis of Variance; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Clusterin; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Glycoproteins; Humans; Microarray Analysis; Models, Biological; Molecular Chaperones; Neuroblastoma; Proteasome Endopeptidase Complex; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subcellular Fractions; Time Factors; Up-Regulation | 2005 |
Growth-associated protein-43 is degraded via the ubiquitin-proteasome system.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; GAP-43 Protein; Gene Expression Regulation; Genetic Vectors; Green Fluorescent Proteins; Immunohistochemistry; Immunoprecipitation; Leupeptins; Male; Mice; Mutagenesis; Neurons; NIH 3T3 Cells; Pregnancy; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Transfection; Ubiquitin | 2005 |
BACE1 gene expression and protein degradation.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Aspartic Acid Endopeptidases; Cell Line, Tumor; Cloning, Molecular; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Isoquinolines; Mutagenesis; Peptide Fragments; Peptide Hydrolases; Phosphopyruvate Hydratase; Promoter Regions, Genetic; Sp1 Transcription Factor; Time Factors; Transfection | 2004 |
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.
Topics: Acetylcysteine; Animals; Endoplasmic Reticulum Chaperone BiP; Female; Fluorescent Antibody Technique; Glucose; Islets of Langerhans; Mice; Microscopy, Confocal; Polyubiquitin; Proinsulin; Proteasome Inhibitors | 2005 |
Effects of exogenous ubiquitin on cell division cycle mutants of Schizosaccharomyces pombe.
Topics: Acetylcysteine; Cell Cycle; Genes, Fungal; Mutation; Proteasome Inhibitors; Schizosaccharomyces; Ubiquitin | 2005 |
Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.
Topics: Acetylcysteine; Acrocephalosyndactylia; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Adhesion; Cysteine Proteinase Inhibitors; DNA Primers; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Fibronectins; Glutamine; Humans; Immunohistochemistry; Immunoprecipitation; Integrin alpha5; Microscopy, Fluorescence; Mutation; Osteoblasts; Phosphotyrosine; Plasmids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-cbl; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Skull; Time Factors; Transfection; Ubiquitin; Ubiquitin-Protein Ligases | 2005 |
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adenoviridae; Adipocytes; Animals; Cell Line; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytoplasm; Down-Regulation; Fibroblasts; Growth Hormone; Humans; Immunoblotting; Immunoprecipitation; Kinetics; Leupeptins; Membrane Proteins; Metalloendopeptidases; Mice; Mice, Knockout; Microscopy, Confocal; Models, Biological; Plasmids; Presenilin-1; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Structure, Tertiary; Receptors, Somatotropin; Recombinant Proteins; Signal Transduction; Time Factors | 2005 |
Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Alkaloids; Blotting, Western; Cell Line; Cell Membrane; Cysteine Proteinase Inhibitors; Cytosol; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Enzyme Inhibitors; Glycosylation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Leupeptins; Long QT Syndrome; Mutation; Potassium Channels; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleases; Subcellular Fractions; Time Factors; Transfection; Ubiquitin | 2005 |
Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration?
Topics: Acetylcysteine; Animals; Apoptosis; Cysteine Proteinase Inhibitors; Dopamine; Humans; Leupeptins; Lewy Bodies; Neurotoxins; Oxidopamine; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protective Agents; Rats; Substantia Nigra | 2005 |
Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization.
Topics: Acetylcysteine; Ammonium Chloride; Analysis of Variance; Animals; Blotting, Western; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Dimerization; Fluorescent Antibody Technique; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Mice; Models, Molecular; Neuroblastoma; Oncogene Proteins; Point Mutation; Polymorphism, Genetic; Protein Deglycase DJ-1; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Subcellular Fractions; Time Factors; Transfection | 2005 |
Selective induction of the tumor marker glutathione S-transferase P1 by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Biomarkers, Tumor; Blotting, Western; Cysteine; DNA-Binding Proteins; DNA, Complementary; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Genes, Dominant; Glutathione S-Transferase pi; Glutathione Transferase; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kelch-Like ECH-Associated Protein 1; Lactones; Leupeptins; Luciferases; Mice; NF-E2-Related Factor 2; Oligonucleotides, Antisense; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Structure, Tertiary; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Time Factors; Trans-Activators; Transfection; Up-Regulation | 2005 |
Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation.
Topics: Acetylcysteine; Animals; Calcium-Binding Proteins; Calpain; Cell Proliferation; Cells, Cultured; Diet, Protein-Restricted; Disease Models, Animal; Female; Fetal Nutrition Disorders; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glycoproteins; Insulin; Insulin Secretion; Islets of Langerhans; Maternal-Fetal Exchange; Peptide Hydrolases; Pregnancy; Proteasome Endopeptidase Complex; Protein Array Analysis; Rats; Rats, Wistar; Taurine | 2005 |
[Inhibiting expression of human telomerase reverse transcriptase promotes degradation of survivin protein].
Topics: Acetylcysteine; Cell Proliferation; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; HeLa Cells; Humans; Inhibitor of Apoptosis Proteins; Leupeptins; Microtubule-Associated Proteins; Neoplasm Proteins; Oligonucleotides, Antisense; RNA, Messenger; Survivin; Telomerase | 2005 |
Inefficient maturation of the rat luteinizing hormone receptor. A putative way to regulate receptor numbers at the cell surface.
Topics: Acetylcysteine; Animals; Blotting, Western; Cell Line; Cell Membrane; Cytosol; Disulfides; DNA; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Gene Expression Regulation; Humans; Immunoblotting; Immunoprecipitation; Ligands; Male; Oligosaccharides; Polysaccharides; Proteasome Endopeptidase Complex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, LH; Subcellular Fractions; Time Factors; Transfection | 2005 |
Electrospray ionization mass spectrometry and ion mobility analysis of the 20S proteasome complex.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Horses; Methanosarcina; Nanotechnology; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
Degradation of HMG-CoA reductase in rat liver is cholesterol and ubiquitin independent.
Topics: Acetylcysteine; Animal Feed; Animals; Cholesterol; Dietary Fats; Hydroxymethylglutaryl CoA Reductases; Liver; Male; Microsomes, Liver; Proteasome Endopeptidase Complex; Protein Binding; Rats; Rats, Sprague-Dawley; Ubiquitin | 2005 |
Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Cells, Cultured; Dopamine; HSP70 Heat-Shock Proteins; Inclusion Bodies; Mesencephalon; Nerve Tissue Proteins; Neurons; Oligopeptides; Proteasome Inhibitors; Rats; Synucleins; Transcription, Genetic; Ubiquitin; Up-Regulation | 2005 |
Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration.
Topics: Acetylcysteine; Animals; Deferoxamine; Iron Chelating Agents; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Proteasome Inhibitors; Substantia Nigra; Treatment Outcome; Ubiquitin | 2005 |
Rapid turnover of GATA-2 via ubiquitin-proteasome protein degradation pathway.
Topics: Acetylcysteine; Animals; Cells, Cultured; Cycloheximide; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; GATA2 Transcription Factor; Gene Deletion; Gene Expression Regulation; Half-Life; Humans; Leukemia, Experimental; Leupeptins; Mice; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation; Ubiquitins; Ultraviolet Rays | 2005 |
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Gene Expression; Gene Expression Profiling; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Leupeptins; Mice; Molecular Chaperones; Muscle Proteins; Neurons; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Transcription, Genetic; Transfection; Up-Regulation | 2005 |
Accumulation of p53 in response to adenovirus early region 1A sensitizes human cells to tumor necrosis factor alpha-induced apoptosis.
Topics: Acetylcysteine; Adenovirus E1A Proteins; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Humans; Lung Neoplasms; Recombinant Proteins; Transfection; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2005 |
Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.
Topics: Acetylcysteine; Apoptosis; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cobalt; Deferoxamine; DNA-Binding Proteins; Flow Cytometry; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Necrosis; Nuclear Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transcription Factors | 2005 |
The effects of proteasome inhibitor lactacystin on mouse oocyte meiosis and first cleavage.
Topics: Acetylcysteine; Animals; Cell Division; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Female; Male; Meiosis; Mice; Microscopy, Confocal; Microtubules; Oocytes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Zygote | 2005 |
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts.
Topics: Acetylcysteine; Antibodies; Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Biological Transport; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cytoplasm; Cytosol; Enzyme Activation; Fibroblasts; Humans; Membrane Glycoproteins; Proteasome Endopeptidase Complex; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; Synovial Membrane; Tissue Distribution; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Ubiquitin; Vimentin | 2005 |
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases | 2005 |
Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2.
Topics: Acetylcysteine; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-X Protein; Caspase 9; Cytochromes c; Gene Expression; Genes, Dominant; Membrane Proteins; Mitochondria; PC12 Cells; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein Transport; Proto-Oncogene Proteins; Rats | 2005 |
Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Brain; Caspase 3; Caspase 8; Caspases; Cell Death; Cell Line, Tumor; Cytoplasm; Cytosol; Detergents; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Exons; HSP70 Heat-Shock Proteins; Immunoblotting; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Neurons; Prions; Proteasome Endopeptidase Complex; Protein Binding; PrPSc Proteins; Subcellular Fractions; Time Factors; Ubiquitin; Vimentin | 2005 |
Cell-specific inhibition of paramyxovirus maturation by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Cell Line; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; HN Protein; Influenza A virus; Leupeptins; Macaca mulatta; Macrophages; Orthomyxoviridae; Paramyxoviridae; Proteasome Inhibitors; Rhabdoviridae; Sendai virus; Vesicular stomatitis Indiana virus; Viral Fusion Proteins; Viral Matrix Proteins; Virus Assembly; Virus Replication | 2005 |
Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme.
Topics: Acetylcysteine; Cell Line; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Gene Products, env; Glucosidases; Hepatitis B virus; Humans; Oligopeptides; Proteasome Endopeptidase Complex; Virus Replication | 2005 |
UV-A light regulation of arylalkylamine N-acetyltransferase activity in the chick pineal gland: role of cAMP and proteasomal proteolysis.
Topics: Acetylcysteine; Animals; Arylalkylamine N-Acetyltransferase; Bucladesine; Chickens; Colforsin; Cyclic AMP; Dark Adaptation; Leupeptins; Male; Oligopeptides; Organ Culture Techniques; Pineal Gland; Proteasome Endopeptidase Complex; Time Factors; Ultraviolet Rays | 2005 |
A formal synthesis of (+)-lactacystin.
Topics: Acetylcysteine; Alkylation; Hydrocarbons; Methane; Molecular Structure; Pyrroles | 2005 |
Proteasome inhibition induces selective motor neuron death in organotypic slice cultures.
Topics: Acetylcysteine; Analysis of Variance; Animals; Animals, Newborn; Cell Count; Cell Death; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Gene Expression Regulation; Immunohistochemistry; Motor Neurons; Neurites; Neurofilament Proteins; Organ Culture Techniques; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 2005 |
[Proteasomal inhibitor lactacystin induces cell apoptosis and caspase 3 activation in PC12 cells].
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; PC12 Cells; Proteasome Inhibitors; Rats | 2005 |
Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation.
Topics: Acetylcysteine; Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Cytochrome P-450 CYP2E1; Cytochrome P450 Family 2; Enzyme Inhibitors; Fibroblasts; HSP90 Heat-Shock Proteins; Humans; Lactones; Macrolides; Proteasome Endopeptidase Complex; Ubiquitin | 2005 |
Oxidative stress response results in increased p21WAF1/CIP1 degradation in cystic fibrosis lung epithelial cells.
Topics: Acetylcysteine; Annexin A5; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cysteine Proteinase Inhibitors; Cystic Fibrosis; Epithelial Cells; Humans; Hyperoxia; Leupeptins; Lung; Oxidative Stress; Oxygen; Reactive Oxygen Species; S Phase | 2006 |
Proteasome mediates removal of proteins oxidized during myocardial ischemia.
Topics: Acetylcysteine; Actins; Animals; Cysteine Proteinase Inhibitors; Heart; Immunoprecipitation; Ischemic Preconditioning, Myocardial; Male; Methylhistidines; Myocardial Ischemia; Oxidation-Reduction; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteins; Rats; Rats, Sprague-Dawley; Reperfusion; Ubiquitin | 2006 |
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Topics: Acetylcysteine; Animals; Benzoquinones; Biological Assay; Cell Line, Tumor; Cell Membrane; Cysteine Proteinase Inhibitors; Endocytosis; Fluorescence Recovery After Photobleaching; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lysosomes; Microscopy, Confocal; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Receptor, ErbB-2 | 2006 |
Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; I-kappa B Kinase; Leupeptins; Male; NF-kappa B; Prostatic Neoplasms; Proteasome Inhibitors; Tumor Cells, Cultured | 2005 |
Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antigens, Nuclear; Apoptosis; Caspase Inhibitors; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Doxorubicin; Gene Expression; HeLa Cells; Humans; Ku Autoantigen; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Signal Transduction; Staurosporine; Ubiquitin; Ubiquitin-Protein Ligase Complexes | 2006 |
NF-kappaB activation is required for cisplatin-induced apoptosis in head and neck squamous carcinoma cells.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Autocrine Communication; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Cysteine Proteinase Inhibitors; Head and Neck Neoplasms; Humans; I-kappa B Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Signal Transduction; Thiocarbamates; Tumor Necrosis Factor-alpha | 2006 |
Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts.
Topics: Acetylcysteine; Anthracenes; Boronic Acids; Bortezomib; Collagen Type I; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Matrix; Fibroblasts; Fibrosis; Genes, jun; Humans; JNK Mitogen-Activated Protein Kinases; Leupeptins; Matrix Metalloproteinase 1; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-jun; Pyrazines; RNA Polymerase II; RNA, Messenger; Scleroderma, Systemic; Skin; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta; Up-Regulation | 2006 |
Heat shock protein 90 is an essential molecular chaperone for nuclear transport of glucocorticoid receptor beta.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adolescent; Aged; Benzoquinones; Blotting, Western; Cell Line; Cell Nucleus; Fluorescent Antibody Technique, Indirect; Gene Expression; Glaucoma, Open-Angle; HSP90 Heat-Shock Proteins; Humans; Immunoblotting; Immunohistochemistry; Lactams, Macrocyclic; Molecular Chaperones; Plasmids; Protein Serine-Threonine Kinases; Receptors, Glucocorticoid; Rifabutin; Trabecular Meshwork; Transfection | 2006 |
Catalytic asymmetric total synthesis of (+)-lactacystin.
Topics: Acetylcysteine; Catalysis; Imines; Lactones; Molecular Structure; Stereoisomerism | 2006 |
Regulation of proteolysis by cytokines in the human intestinal epithelial cell line HCT-8: role of IFNgamma.
Topics: Acetylcysteine; Blotting, Western; Cell Line, Tumor; Cytokines; Epithelial Cells; Gene Expression; Humans; Hydrolysis; Interferon-gamma; Interleukin-1; Interleukin-8; Intestinal Mucosa; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha; Ubiquitin; Ubiquitin C | 2006 |
Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum.
Topics: Acetylcysteine; Alternative Splicing; Animals; Calnexin; Calreticulin; Cells, Cultured; Chorionic Gonadotropin; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Humans; Molecular Chaperones; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Folding; Protein Structure, Tertiary; Protein Transport; Rats; Receptors, LH | 2006 |
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Cytoplasm; Enzyme Inhibitors; Exportin 1 Protein; Fatty Acids, Unsaturated; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Karyopherins; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; RNA Interference; Transfection; Ubiquitin | 2006 |
A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from the proteasome to the lysosome.
Topics: Acetylcysteine; Animals; Binding, Competitive; Biological Transport; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Cysteine Proteinase Inhibitors; Humans; Lipoproteins, LDL; Lysosomes; Mutant Proteins; Point Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Receptors, LDL; Signal Transduction | 2006 |
Constitutively expressed catalytic proteasomal subunits are up-regulated during neuronal differentiation and required for axon initiation, elongation and maintenance.
Topics: Acetylcysteine; Animals; Animals, Newborn; Catalytic Domain; Cell Differentiation; Cell Survival; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Ganglia, Autonomic; Ganglia, Sensory; Growth Cones; Microscopy, Electron, Scanning; Nerve Degeneration; Nerve Growth Factor; Nerve Net; Nervous System; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; RNA, Messenger; Up-Regulation | 2006 |
Accumulation of the pro-apoptotic factor Bak is controlled by antagonist factor Mcl-1 availability.
Topics: Acetylcysteine; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Cell Line; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2 | 2006 |
Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Carrier Proteins; Cells, Cultured; Co-Repressor Proteins; Cytomegalovirus; Cytomegalovirus Infections; Gene Expression Regulation, Viral; Gene Silencing; Genes, Immediate-Early; Humans; Intracellular Signaling Peptides and Proteins; Molecular Chaperones; Nuclear Proteins; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Viral Proteins | 2006 |
Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Implants; Female; Glioma; Gliosarcoma; Infusions, Intralesional; Neoplasms, Experimental; Polymers; Rats; Rats, Inbred F344 | 2006 |
Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.
Topics: Acetylcysteine; Cell Line; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Humans; Kinetics; Lung Neoplasms; Phosphorylation; Proteasome Endopeptidase Complex; Receptor, IGF Type 1; Tyrosine; Ubiquitin | 2006 |
Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages.
Topics: Acetylcysteine; Atherosclerosis; CD36 Antigens; Ceramides; Gene Expression Regulation; Humans; Lipoproteins, LDL; Macrophages; Proteasome Endopeptidase Complex; Protein Transport; RNA, Messenger; U937 Cells | 2006 |
Protective role of heat shock and heat shock protein 70 in lactacystin-induced cell death both in the rat substantia nigra and PC12 cells.
Topics: Acetylcysteine; Analysis of Variance; Animals; Blotting, Western; Cell Count; Cell Death; Cysteine Proteinase Inhibitors; Gene Expression; Heat-Shock Response; HSP72 Heat-Shock Proteins; Hyperthermia, Induced; Immunohistochemistry; Male; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation.
Topics: Acetylcysteine; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Activation; Glycogen Synthase Kinase 3; Humans; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Inhibitors; Protein Phosphatase 2; tau Proteins | 2006 |
Role of the proteasome in TGF-beta signaling in lens epithelial cells.
Topics: Acetylcysteine; Actins; Annexins; Blotting, Western; Cataract; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Fibronectins; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutamate-Cysteine Ligase; Humans; Intracellular Signaling Peptides and Proteins; Lens, Crystalline; Leupeptins; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad2 Protein; Transcriptional Activation; Transforming Growth Factor beta | 2006 |
Key inflammatory signaling pathways are regulated by the proteasome.
Topics: Acetylcysteine; Animals; Cell Survival; Chymotrypsin; Gene Expression Regulation, Enzymologic; Inflammation; Lipopolysaccharides; Macrophages; Mice; Oligonucleotide Array Sequence Analysis; Proteasome Endopeptidase Complex; Shock, Septic; Signal Transduction; Toll-Like Receptor 4 | 2006 |
Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Chromosome Breakage; Cisplatin; Comet Assay; DNA Damage; Doxorubicin; Etoposide; Gamma Rays; Gene Expression Regulation; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Interleukin-6; KB Cells; Leupeptins; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Proteasome Inhibitors; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sulfones; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 2006 |
Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor.
Topics: Acetylcysteine; Animals; Catalysis; Drug Evaluation, Preclinical; Imides; Lactams; Lactones; Molecular Structure; Protease Inhibitors; Proteasome Inhibitors; Rabbits; Stereoisomerism | 2006 |
Proteasome-mediated regulation of CpG DNA- and peptidoglycan-induced cytokines, inflammatory genes, and mitogen-activated protein kinase activation.
Topics: Acetylcysteine; Animals; Cell Line; CpG Islands; Cysteine Proteinase Inhibitors; Cytokines; DNA, Bacterial; Gene Expression Regulation; Inflammation; Macrophages; MAP Kinase Signaling System; Mice; Peptidoglycan; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein-Tyrosine Kinases; Transcription Factor AP-1 | 2006 |
OPG/membranous--RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation.
Topics: Acetylcysteine; Animals; Antibodies; Blotting, Western; Cell Line; Cells, Cultured; Chloroquine; Clathrin; Cysteine Proteinase Inhibitors; Enzyme-Linked Immunosorbent Assay; Heparin; Humans; Lysosomes; Mice; Microscopy, Confocal; Osteoclasts; Osteoprotegerin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Syndecans | 2006 |
Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Animals; Becaplermin; Cell Proliferation; Cyclic AMP Response Element-Binding Protein; Cysteine Proteinase Inhibitors; Fatty Acids, Unsaturated; Humans; Mutation; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Recombinant Fusion Proteins; Serine; Signal Transduction; Ubiquitin | 2006 |
PU.1 is degraded in differentiation of erythrocytes through a proteasome-dependent pathway.
Topics: Acetylcysteine; Cell Differentiation; Cell Line; Electrophoresis, Gel, Two-Dimensional; Erythrocytes; Hydrolysis; Immunoprecipitation; Proto-Oncogene Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trans-Activators | 2006 |
PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Membrane Microdomains; Mice; Microscopy, Electron, Transmission; Microscopy, Immunoelectron; Neurons; Proteasome Inhibitors; Protein Transport; PTEN Phosphohydrolase | 2006 |
The neuroprotective role of attractin in neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Analysis of Variance; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Survival; Cytochromes c; Gene Expression Regulation; Humans; In Situ Hybridization; Membrane Proteins; Nerve Degeneration; Neurotoxins; RNA, Small Interfering; Transfection; Tyrosine 3-Monooxygenase | 2007 |
Constitutive activity of glycogen synthase kinase-3beta: positive regulation of steady-state levels of insulin receptor substrates-1 and -2 in adrenal chromaffin cells.
Topics: Acetylcysteine; Adjuvants, Immunologic; Adrenal Glands; Animals; Blotting, Northern; Cattle; Cells, Cultured; Chromaffin Cells; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Glycogen Synthase Kinase 3; Indoles; Lactones; Lithium Chloride; Maleimides; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Serine; Time Factors | 2006 |
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Proteasome dysfunction inhibits surfactant protein gene expression in lung epithelial cells: mechanism of inhibition of SP-B gene expression.
Topics: Acetylcysteine; Base Sequence; Cell Line; Cysteine Proteinase Inhibitors; Dexamethasone; DNA-Binding Proteins; Epithelial Cells; Gene Expression; Humans; Leupeptins; Lung; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein C; RNA, Messenger; Transcription Factors | 2007 |
Comparison of the neurotoxic effects of proteasomal inhibitors in primary mesencephalic cultures.
Topics: Acetylcysteine; Analysis of Variance; Animals; Cell Count; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; gamma-Aminobutyric Acid; Immunohistochemistry; Mesencephalon; Neurons; Neurotoxins; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Tritium | 2006 |
Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
Topics: Acetylcysteine; Adenoviridae; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cell Survival; CHO Cells; Cricetinae; Culture Media; Cysteine Proteinase Inhibitors; Depression, Chemical; Enzyme-Linked Immunosorbent Assay; Humans; Nerve Tissue Proteins; Neurons; Rats; Subcellular Fractions | 2006 |
Lactacystin inhibits 3T3-L1 adipocyte differentiation through induction of CHOP-10 expression.
Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cyclin-Dependent Kinase 2; DNA; Mice; Mitosis; Protein Binding; Transcription Factor CHOP; Up-Regulation | 2006 |
Isolation and characterization of mammalian D-aspartyl endopeptidase.
Topics: Acetylcysteine; Aging; Alzheimer Disease; Animals; Aspartic Acid Endopeptidases; Caenorhabditis elegans; D-Aspartic Acid; Escherichia coli; Glutamate Dehydrogenase; Mice; Mitochondrial Membranes; Mitochondrial Proteins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Saccharomyces cerevisiae; Succinate Dehydrogenase | 2007 |
Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9.
Topics: Acetylcysteine; Adipocytes; Adipogenesis; Cell Differentiation; Cells, Cultured; HIV Protease Inhibitors; Humans; I-kappa B Proteins; Matrix Metalloproteinase 9; NF-KappaB Inhibitor alpha; Nitriles; Proteasome Inhibitors; Stem Cells; Sulfones; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2007 |
Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells.
Topics: Acetylcysteine; Animals; Apoptosis; CDC2 Protein Kinase; Cell Division; Cell Line, Tumor; Cell Proliferation; Cyclin B; Cyclin B1; DNA Damage; G2 Phase; Isothiocyanates; Male; Mice; Pancreatic Neoplasms | 2006 |
Ubiquitin-proteasome pathway mediates degradation of APH-1.
Topics: Acetylcysteine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Brain; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Inhibitors; Membrane Proteins; Mice; Neurons; Peptide Hydrolases; Presenilin-1; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA Interference; Signal Transduction; Time Factors; Ubiquitin; Up-Regulation | 2006 |
Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells.
Topics: Acetylcysteine; Apoptosis; Boronic Acids; Bortezomib; Cell Differentiation; Chymases; Cysteine Proteinase Inhibitors; Dendritic Cells; Endocytosis; Humans; Interleukin-12; Lymphocyte Activation; Monocytes; Oligopeptides; Pinocytosis; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Receptors, Cell Surface | 2007 |
Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: comparison with arsenite.
Topics: Acetylcysteine; Animals; Arsenites; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Hepatocytes; Leupeptins; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Inbred F344; RNA, Messenger | 2006 |
Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental.
Topics: Acetylcysteine; Amino Acid Sequence; Aminopeptidases; Animals; Antigen Presentation; Antigens, Viral; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class I; Hydrolysis; Influenza A virus; L Cells; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Nucleocapsid Proteins; Nucleoproteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA-Binding Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; T-Lymphocytes, Cytotoxic; Vaccinia virus; Viral Core Proteins | 2006 |
Regulation of STIM1, store-operated Ca2+ influx, and nitric oxide generation by retinoic acid in rat mesangial cells.
Topics: Acetylcysteine; Animals; Blotting, Western; Bradykinin; Calcium; Calcium Signaling; Cells, Cultured; Cysteine Proteinase Inhibitors; Gene Expression; Glucose; Membrane Glycoproteins; Mesangial Cells; Nitric Oxide; Nitric Oxide Synthase Type III; Proteasome Inhibitors; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stromal Interaction Molecule 1; Transforming Growth Factor beta; Tretinoin | 2007 |
Regulation of catechol-O-methyltransferase expression in human myometrial cells.
Topics: Acetylcysteine; Blotting, Western; Catechol O-Methyltransferase; Cells, Cultured; Down-Regulation; Estrogens; Female; Genes, Reporter; Humans; Hydroxyestrones; Luciferases; Myometrium; Progesterone; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation | 2006 |
Detection of a proteasome in Pneumocystis carinii and its modulation by specific proteasome inhibitors.
Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Line; Coumarins; Genes, Fungal; HIV Protease Inhibitors; Humans; Lopinavir; Models, Animal; Oligopeptides; Pneumocystis carinii; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrimidinones; Rats | 2006 |
Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells.
Topics: Acetylcysteine; Calpain; Catenins; Cell Adhesion Molecules; Cell Aggregation; Cell Death; Cell Line, Tumor; Delta Catenin; Dipeptides; Humans; Ischemia; Leupeptins; Neuroblastoma; Phosphoproteins | 2007 |
Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry.
Topics: Acetylcysteine; Biomarkers; Cell Line; Cell Nucleus; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique, Indirect; Hepatocytes; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Interphase; Microscopy, Confocal; Proteasome Endopeptidase Complex; Tissue Fixation | 2007 |
Iron-dependent degradation of apo-IRP1 by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Carbon-Sulfur Lyases; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Humans; Iron; Iron Regulatory Protein 1; Leupeptins; Metabolic Networks and Pathways; Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Transcriptional Activation; Ubiquitin | 2007 |
Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.
Topics: Acetylcysteine; Crystallography, X-Ray; Humans; Lactones; Molecular Conformation; Molecular Structure; Proteasome Inhibitors; Pyrroles; Streptomyces | 2007 |
Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Culture Techniques; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelium; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mesoderm; Mice; Mice, Transgenic; Phenotype; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-cbl; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; RNA, Small Interfering | 2007 |
Post-induction, stimulus-specific regulation of tumor necrosis factor mRNA expression.
Topics: Acetylcysteine; Amino Acid Motifs; Animals; Deoxyribonuclease I; DNA; Gene Expression Regulation; Humans; Ionophores; Lipopolysaccharides; Mice; NF-kappa B; Proteasome Inhibitors; Protein Structure, Tertiary; RNA, Messenger; Tumor Necrosis Factor-alpha | 2007 |
Degradation of nicastrin involves both proteasome and lysosome.
Topics: Acetylcysteine; Amyloid Precursor Protein Secretases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Humans; Lysosomes; Membrane Glycoproteins; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Transfection | 2007 |
Lafora disease proteins malin and laforin are recruited to aggresomes in response to proteasomal impairment.
Topics: Acetylcysteine; Animals; Carrier Proteins; Cell Line; Cell Line, Tumor; Centrosome; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Green Fluorescent Proteins; Humans; Immunoblotting; Immunohistochemistry; Inclusion Bodies; Lafora Disease; Leupeptins; Microscopy, Fluorescence; Proteasome Endopeptidase Complex; Protein Binding; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Recombinant Fusion Proteins; Transfection; Tubulin; Ubiquitin; Ubiquitin-Protein Ligases | 2007 |
Effects of tau phosphorylation on proteasome activity.
Topics: Acetylcysteine; Cells, Cultured; Colforsin; Cysteine Proteinase Inhibitors; Humans; Okadaic Acid; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; tau Proteins | 2007 |
Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Apoptosomes; Apoptotic Protease-Activating Factor 1; Baculoviral IAP Repeat-Containing 3 Protein; Caspases; Cell Line, Tumor; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Lymphoma, B-Cell; Membrane Microdomains; Mitochondrial Proteins; Staurosporine; Ubiquitin-Protein Ligases | 2007 |
Endoplasmic reticulum stress-induced cell death mediated by the proteasome.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Brefeldin A; Caspase 3; Cells, Cultured; Chlorhexidine; Cytochromes c; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; Mitochondrial Membranes; Models, Biological; Phosphatidylserines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Sulfones; Temperature; Ubiquitin-Activating Enzymes | 2007 |
Proteasomes and RARS modulate AIMP1/EMAP II secretion in human cancer cell lines.
Topics: Acetylcysteine; Arginine-tRNA Ligase; Breast Neoplasms; Cysteine Proteinase Inhibitors; Cytokines; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Neoplasm Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; RNA-Binding Proteins; Transfection; Uterine Cervical Neoplasms | 2007 |
Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different species.
Topics: Acetylcysteine; Acrylates; Animals; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP1A1; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Antagonism; Drug Combinations; Environmental Pollutants; Humans; Mice; Oligopeptides; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon | 2007 |
Determinants of growth hormone receptor down-regulation.
Topics: Acetylcysteine; Animals; Cell Line; Chloroquine; Cycloheximide; Down-Regulation; Human Growth Hormone; Humans; Janus Kinase 2; Lysosomes; Mice; Mutation; Phosphorylation; Proteasome Inhibitors; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Rabbits; Receptors, Somatotropin; Recombinant Proteins; Transfection; Tyrosine | 2007 |
Beta-amyloid (25-35) enhances lipid metabolism and protein ubiquitination in cultured neurons.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Caspases; Cells, Cultured; Chymotrypsin; Cysteine Proteinase Inhibitors; Hippocampus; Lipid Metabolism; Microscopy, Electron; Nerve Tissue Proteins; Neurons; Palmitic Acid; Peptide Fragments; Rats; Tritium; Ubiquitin | 2007 |
Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model.
Topics: Acetylcysteine; Bacterial Proteins; Chlamydia Infections; Chlamydia trachomatis; Gene Library; HeLa Cells; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Interaction Mapping; Transcription Factors; Yersinia | 2007 |
Adrenoleukodystrophy: subcellular localization and degradation of adrenoleukodystrophy protein (ALDP/ABCD1) with naturally occurring missense mutations.
Topics: Acetylcysteine; Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding Cassette Transporters; CHO Cells; Cricetinae; Cricetulus; Fibroblasts; Humans; Leupeptins; Mutation, Missense; Proteasome Inhibitors; Subcellular Fractions | 2007 |
Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures.
Topics: Acetylcysteine; Animals; Calcium; Calcium Channels, L-Type; Cells, Cultured; DNA Primers; Dopamine; Homeostasis; Mesencephalon; Models, Animal; Neurons; Polymerase Chain Reaction; Proteasome Inhibitors; Rats; RNA; Ubiquitin | 2007 |
Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin.
Topics: Acetylcysteine; Animals; Bone Marrow Cells; Cells, Cultured; Culture Media, Conditioned; DNA, Recombinant; Genetic Therapy; Genetic Vectors; Glial Cell Line-Derived Neurotrophic Factor; Lentivirus; Neurons; Neuroprotective Agents; PC12 Cells; Plasmids; Protease Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stromal Cells; Transduction, Genetic | 2007 |
Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture.
Topics: Acetylcysteine; Apoptosis; Barrett Esophagus; Carcinoma, Squamous Cell; Cell Line, Tumor; Cells, Cultured; Chenodeoxycholic Acid; Cyclooxygenase 2; Deoxycholic Acid; DNA-Binding Proteins; Down-Regulation; Doxorubicin; Esophageal Neoplasms; Esophagus; Fluorescent Antibody Technique; Humans; Hydrogen-Ion Concentration; Leupeptins; Proteasome Inhibitors; Taurochenodeoxycholic Acid; Trans-Activators; Transcription Factors; Tumor Suppressor Proteins | 2007 |
Cellular Zn2+ chelators cause "dying-back" neurite degeneration associated with energy impairment.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Chelating Agents; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuritis; Organ Culture Techniques; Superior Cervical Ganglion; Time Factors | 2007 |
Proteasomal inhibition and apoptosis regulatory changes in human isolated lymphocytes: the synergistic role of dopamine.
Topics: Acetylcysteine; Adult; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Survival; Cysteine Proteinase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Female; Genes, bcl-2; Humans; In Vitro Techniques; Lymphocyte Count; Lymphocytes; Male; Middle Aged; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitin | 2008 |
Membrane cytosolic translocation of verotoxin A1 subunit in target cells.
Topics: Acetylcysteine; Animals; Brefeldin A; Cell Membrane; Cell Survival; Chlorocebus aethiops; Cold Temperature; Cysteine Proteinase Inhibitors; Cytosol; Endoplasmic Reticulum; Golgi Apparatus; Microscopy, Confocal; Protein Biosynthesis; Protein Subunits; Protein Transport; Shiga Toxins; Vero Cells | 2007 |
Reduction of infectious bursal disease virus replication in cultured cells by proteasome inhibitors.
Topics: Acetylcysteine; Animals; Antiviral Agents; Apoptosis; Cell Line; Chick Embryo; Chickens; Cytopathogenic Effect, Viral; Fibroblasts; Infectious bursal disease virus; Leupeptins; Proteasome Inhibitors; Protein Biosynthesis; RNA, Viral; Transcription, Genetic; Viral Proteins; Virus Internalization | 2007 |
Prevention and restoration of lactacystin-induced nigrostriatal dopamine neuron degeneration by novel brain-permeable iron chelators.
Topics: Acetylcysteine; Animals; Blood-Brain Barrier; Dopamine; Goats; Hydroxyquinolines; Iron Chelating Agents; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Rabbits; Substantia Nigra | 2007 |
NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Cysteine Proteinase Inhibitors; Epithelial Cells; Indomethacin; Leupeptins; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; RNA, Messenger; Stomach; Survivin; Ubiquitination | 2007 |
Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Feasibility Studies; Intercellular Adhesion Molecule-1; Intestines; L-Lactate Dehydrogenase; Liver; Liver Diseases; Male; Neutrophil Infiltration; Peroxidase; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Reperfusion Injury; Transcription Factor RelA | 2007 |
PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.
Topics: Acetylcysteine; Animals; Butyrates; Cells, Cultured; Dose-Response Relationship, Drug; Leupeptins; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phenylurea Compounds; PPAR alpha; Proteasome Endopeptidase Complex; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; STAT1 Transcription Factor | 2007 |
Glial cell-derived neurotrophic factor protects against proteasome inhibition-induced dopamine neuron degeneration by suppression of endoplasmic reticulum stress and caspase-3 activation.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Cells, Cultured; Dopamine; Endoplasmic Reticulum; Enzyme Activation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Inclusion Bodies; Nerve Degeneration; Neurons; Parkinson Disease; Proteasome Inhibitors; Rats; Recombinant Proteins | 2007 |
Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress.
Topics: Acetylcysteine; Alternative Splicing; Animals; Base Sequence; Cell Line; Cell Nucleolus; Cell Nucleus; Chickens; Cysteine Proteinase Inhibitors; Cytoplasm; Dactinomycin; DNA-Binding Proteins; Exons; Gene Deletion; Heat-Shock Response; Humans; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Proteasome Inhibitors; Protein Isoforms; Protein Structure, Tertiary; RNA, Messenger; Transcription, Genetic | 2007 |
Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Antibodies; Blotting, Western; Cadherins; Cell Adhesion; Cell Line, Tumor; Culture Media, Conditioned; DNA, Neoplasm; Dogs; Down-Regulation; Extracellular Matrix; Hepatocyte Growth Factor; Humans; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Phosphorylation; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-met; Tyrosine | 2008 |
The proteasome and intracellular redox status: implications for apoptotic regulation in lens epithelial cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Cysteine Proteinase Inhibitors; Epithelial Cells; Glutathione; Glutathione Disulfide; Humans; Hydrogen Peroxide; In Vitro Techniques; Intracellular Membranes; Lens, Crystalline; Leupeptins; Mice; Oxidants; Oxidation-Reduction; Oxidative Stress; Peptide Hydrolases; Proteasome Endopeptidase Complex | 2007 |
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
Topics: Acetylcysteine; Animals; Cell Communication; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Endocytosis; Enzyme Inhibitors; Ephrin-B1; Humans; Lysosomes; Macrolides; Mice; Models, Biological; Mutation; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-cbl; Pyrimidines; Receptor, EphB1; Signal Transduction; src-Family Kinases; Transfection; Ubiquitination | 2008 |
Downregulation of parkin damages antioxidant defenses and enhances proteasome inhibition-induced toxicity in PC12 cells.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Survival; Down-Regulation; Humans; Oxidative Stress; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Ubiquitin-Protein Ligases | 2007 |
Oxidative injury induces selective rather than global inhibition of proteasomal activity.
Topics: Acetylcysteine; Animals; Cell Line; Cell Nucleus; Endoplasmic Reticulum; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Ischemic Preconditioning, Myocardial; Kelch-Like ECH-Associated Protein 1; Male; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proteins; Rats; Rats, Sprague-Dawley | 2008 |
Dendritic cells process antigens encapsulated in a biodegradable polymer, poly(D,L-lactide-co-glycolide), via an alternate class I MHC processing pathway.
Topics: Acetylcysteine; Antigen Presentation; ATP Binding Cassette Transporter, Subfamily B, Member 2; ATP-Binding Cassette Transporters; Brefeldin A; Cell Line; Chloroquine; Dendritic Cells; Histocompatibility Antigens Class I; Humans; Lactic Acid; Nanospheres; Ovalbumin; Phagocytosis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers | 2007 |
Yessotoxin inhibits the complete degradation of E-cadherin.
Topics: Acetylcysteine; Animals; Cadherins; Cell Adhesion; Cell Line, Tumor; Cysteine Proteinase Inhibitors; DNA; Dogs; Electrophoresis, Polyacrylamide Gel; Endocytosis; Ethers, Cyclic; Immunoblotting; Immunoprecipitation; Membrane Proteins; Mice; Mollusk Venoms; Oxocins; Trypsin | 2008 |
Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro.
Topics: Acetylcysteine; Actins; Animals; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Cytoskeleton; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Heat-Shock Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Microscopy, Fluorescence; Nerve Tissue Proteins; Neurons; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Time Factors; Tubulin; Ubiquitin | 2008 |
Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits.
Topics: Acetylcysteine; Apoptosis; B-Lymphocytes; Boronic Acids; Bortezomib; Cell Line, Tumor; Cysteine Endopeptidases; Drug Screening Assays, Antitumor; Humans; Interferon-gamma; Lymphoma; Multienzyme Complexes; Multiple Myeloma; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Subunits; Pyrazines | 2008 |
Efficient total synthesis of novel bioactive microbial metabolites.
Topics: Acetylcysteine; Alkaloids; Biological Products; Humans; Indoles; Molecular Structure; Pyrans; Pyridines | 2008 |
Proteasome inhibition suppresses essential immune functions of human CD4+ T cells.
Topics: Acetylcysteine; Antigens, CD; Apoptosis; Boronic Acids; Bortezomib; CD4-Positive T-Lymphocytes; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cytokines; Dose-Response Relationship, Immunologic; Humans; Immunosuppressive Agents; Lymphocyte Activation; NFATC Transcription Factors; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Translocation, Genetic; Tumor Suppressor Protein p53 | 2008 |
Enantioselective total syntheses of omuralide, 7-epi-omuralide, and (+)-lactacystin.
Topics: Acetylcysteine; Anti-Bacterial Agents; Crystallography, X-Ray; Lactones; Stereoisomerism | 2008 |
Proteasome inhibitors remarkably prevent translesion replication in cancer cells but not normal cells.
Topics: Acetylcysteine; Boronic Acids; Caffeine; Cells, Cultured; Cisplatin; Cysteine Proteinase Inhibitors; DNA Damage; DNA Repair; DNA Replication; HeLa Cells; Humans; Leupeptins; Neoplasms; Proteasome Inhibitors; Tumor Cells, Cultured; Ultraviolet Rays | 2008 |
Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein.
Topics: Acetylcysteine; alpha-Synuclein; Anti-Infective Agents, Local; Benzimidazoles; Blotting, Western; Dequalinium; Fluorescent Dyes; Green Fluorescent Proteins; Organic Chemicals; Plasmids; Proteasome Inhibitors; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Yeasts | 2008 |
Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines.
Topics: Acetylcysteine; Blotting, Northern; Cell Line, Tumor; Cycloheximide; Dactinomycin; Ethanol; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Kinase 4; Neoplasm Metastasis; Ovarian Neoplasms; Polymerase Chain Reaction; Prostatic Neoplasms; Protein Biosynthesis | 2008 |
Inhibition of plasminogen activator inhibitor-1 expression in vascular smooth muscle cells by protoporphyrins through a heme oxygenase-independent mechanism.
Topics: Acetylcysteine; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Heme Oxygenase-1; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plasminogen Activator Inhibitor 1; Proteasome Inhibitors; Protoporphyrins; RNA, Messenger; Transforming Growth Factor beta1 | 2008 |
BV-2 stimulation by lactacystin results in a strong inflammatory reaction and apoptotic neuronal death in SH-SY5Y cells.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Apoptosis; Cell Line; Cell Survival; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; I-kappa B Proteins; Inflammation; Macrophage Activation; Mice; Microglia; Minocycline; Neurons; NF-KappaB Inhibitor alpha; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Proteasome Endopeptidase Complex | 2008 |
NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b).
Topics: Acetylcysteine; Animals; Cell Cycle; Cell Line, Tumor; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Leupeptins; NAD(P)H Dehydrogenase (Quinone); Nuclear Proteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine; Tumor Suppressor Proteins; Ultraviolet Rays | 2008 |
Simultaneous presentation and cross-presentation of immune-stimulating complex-associated cognate antigen by antigen-specific B cells.
Topics: Acetylcysteine; Adoptive Transfer; Animals; Antigen Presentation; Antigens; B-Lymphocytes; Brefeldin A; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Proliferation; Chloroquine; Cysteine Proteinase Inhibitors; Epitopes, B-Lymphocyte; ISCOMs; Kinetics; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mice, Transgenic; Muramidase; Ovalbumin; Peptide Fragments; Receptors, Antigen, T-Cell; Vaccination | 2008 |
Comparison of neuroprotective and neurorestorative capabilities of rasagiline and selegiline against lactacystin-induced nigrostriatal dopaminergic degeneration.
Topics: Acetylcysteine; Animals; Dopamine; Indans; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Selegiline | 2008 |
Promotion of neurite outgrowth by fibroblast growth factor receptor 1 overexpression and lysosomal inhibition of receptor degradation in pheochromocytoma cells and adult sensory neurons.
Topics: Acetylcysteine; Animals; Blotting, Western; Cysteine Proteinase Inhibitors; Fibroblast Growth Factors; Ganglia, Spinal; Green Fluorescent Proteins; Leupeptins; Ligands; Lysosomes; Neurites; PC12 Cells; Pheochromocytoma; Rats; Receptor, Fibroblast Growth Factor, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Sensory Receptor Cells; Signal Transduction | 2008 |
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.
Topics: Acetylcholine; Acetylcysteine; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Basal Nucleus of Meynert; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Lewy Bodies; Lewy Body Disease; Male; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Ubiquitin | 2008 |
Proteasome inhibition increases tau accumulation independent of phosphorylation.
Topics: Acetylcysteine; Animals; Cyclic AMP-Dependent Protein Kinases; Cyclin-Dependent Kinase 5; Cysteine Proteinase Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; JNK Mitogen-Activated Protein Kinases; Male; Memory; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Phosphatase 2; Rats; Rats, Wistar; Space Perception; tau Proteins; Ubiquitination | 2009 |
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Glial Cell Line-Derived Neurotrophic Factor; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Nerve Degeneration; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphatidylinositol 3-Kinases; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Random Allocation; Signal Transduction; Substantia Nigra | 2008 |
Practical synthesis of a key intermediate for lactacystin from (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate.
Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Oxazoles; Solvents; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared | 2008 |
Cadmium-induced activation of stress signaling pathways, disruption of ubiquitin-dependent protein degradation and apoptosis in primary rat Sertoli cell-gonocyte cocultures.
Topics: Acetylcysteine; Animals; Apoptosis; Cadmium Compounds; Cell Survival; Cells, Cultured; Coculture Techniques; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Leupeptins; Male; Oxidative Stress; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Spermatogonia; Ubiquitins | 2008 |
The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells.
Topics: Acetylcysteine; Amyloid Precursor Protein Secretases; Animals; Binding Sites; Cell Line; Cytoplasm; Endosomes; Epithelial Cells; Gene Expression Regulation; Golgi Apparatus; Kidney Tubules, Proximal; Low Density Lipoprotein Receptor-Related Protein-2; Microvilli; Opossums; Peptide Fragments; Plasmids; Protease Inhibitors; Protein Processing, Post-Translational; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transfection | 2008 |
Morphine induces ubiquitin-proteasome activity and glutamate transporter degradation.
Topics: Acetylcysteine; Amino Acid Transport System X-AG; Analgesics, Opioid; Animals; Chloroquine; Excitatory Amino Acid Transporter 3; Humans; Leupeptins; Male; Morphine; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitin | 2008 |
A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer.
Topics: Acetylcysteine; Adenomatous Polyposis Coli; Animals; Antineoplastic Agents, Phytogenic; Camellia sinensis; Catechin; Cell Transformation, Neoplastic; Colorectal Neoplasms; Cycloheximide; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Fibroblast Growth Factor 2; Genes, APC; HCT116 Cells; HT29 Cells; Humans; Mice; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Time Factors; Transfection | 2008 |
Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity.
Topics: Acetylcysteine; Animals; Astrocytes; Benzothiazoles; Brain-Derived Neurotrophic Factor; Cell Death; Cell Line, Tumor; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Microtubule-Associated Proteins; Neurons; Pramipexole; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Tyrosine 3-Monooxygenase | 2008 |
Efficient MHC class I presentation by controlled intracellular trafficking of antigens in octaarginine-modified liposomes.
Topics: Acetylcysteine; Amiloride; Animals; Antigen Presentation; Bone Marrow Cells; Cell Line, Tumor; Cells, Cultured; Dendritic Cells; Flow Cytometry; Histocompatibility Antigens Class I; Intracellular Space; Liposomes; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neoplasms, Experimental; Nocodazole; Oligopeptides; Tumor Burden | 2008 |
Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo.
Topics: Acetylcysteine; Analysis of Variance; Animals; Apoptosis; Brain Injuries; Causality; Cell Line, Tumor; DNA-Binding Proteins; Dopamine; Gene Expression Regulation; Humans; Male; Mice; Mice, Knockout; Neuroblastoma; Neurons; Nuclear Receptor Subfamily 4, Group A, Member 2; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Transcription Factors; Transfection; Tyrosine 3-Monooxygenase | 2008 |
Inhibition of proteasome activity blocks Trypanosoma cruzi growth and metacyclogenesis.
Topics: Acetylcysteine; Animals; Cell Adhesion; Cell Division; Culture Media; Cysteine Proteinase Inhibitors; DNA Replication; DNA, Kinetoplast; Dose-Response Relationship, Drug; Flow Cytometry; Inhibitory Concentration 50; Microscopy; Microscopy, Electron, Transmission; Mitochondria; Proteasome Inhibitors; Time Factors; Trypanosoma cruzi | 2008 |
Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells.
Topics: Acetylcysteine; Blotting, Northern; Cell Adhesion; Cells, Cultured; Cytokines; Cytosol; Drug Synergism; Endothelial Cells; Gene Expression Regulation; Humans; I-kappa B Proteins; Insulin; Lipopolysaccharides; Monocytes; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; RNA, Messenger; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Cord; Vascular Cell Adhesion Molecule-1 | 2008 |
Protein degradation, as with protein synthesis, is required during not only long-term spatial memory consolidation but also reconsolidation.
Topics: Acetylcysteine; Animals; Anisomycin; Cysteine Proteinase Inhibitors; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory; Mice; Nerve Tissue Proteins; Neurons; Protein Synthesis Inhibitors; Space Perception | 2008 |
Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement.
Topics: Acetylcysteine; Animals; Autophagy; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Protein Folding; Rats; Sirolimus | 2008 |
Study of the effects of proteasome inhibitors on ribosomal protein S19 (RPS19) mutants, identified in patients with Diamond-Blackfan anemia.
Topics: Acetylcysteine; Anemia, Diamond-Blackfan; Animals; Child; Child, Preschool; Chlorocebus aethiops; Cloning, Molecular; Codon; COS Cells; Female; Humans; Infant; Male; Mutation; Proteasome Inhibitors; Recombinant Fusion Proteins; Ribosomal Proteins | 2008 |
Lactacystin stimulates stellation of cultured rat cortical astrocytes.
Topics: Acetylcysteine; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Cerebral Cortex; Lysophospholipids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-akt; Rats; rhoA GTP-Binding Protein; Signal Transduction | 2009 |
Proteasome-dependent degradation of Chk1 kinase induced by the topoisomerase II inhibitor R16 contributes to its anticancer activity.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Inhibitors; Flow Cytometry; HSP90 Heat-Shock Proteins; Humans; Leupeptins; Naphthalimides; Proteasome Endopeptidase Complex; Protein Kinases; Thiophenes; Time Factors; Topoisomerase II Inhibitors; Ubiquitin | 2008 |
Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspase Inhibitors; cdc25 Phosphatases; Cell Line, Tumor; Cyclin A1; Cyclin-Dependent Kinase 2; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Humans; Leukemia; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Staurosporine; Tumor Necrosis Factor-alpha; Ubiquitination | 2009 |
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Cytochromes c; Dopamine; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; Tetrazolium Salts; Thiazoles | 2008 |
A new synthetic approach to (+)-lactacystin based on radical cyclisation of enantiopure alpha-ethynyl substituted serine derivatives to 4-methylenepyrrolidinones.
Topics: Acetylcysteine; Cyclization; Free Radicals; Methylation; Molecular Structure; Pyrrolidinones; Serine; Stereoisomerism | 2008 |
The ubiquitin-proteasome system is necessary for long-term synaptic depression in Aplysia.
Topics: Acetylation; Acetylcysteine; Animals; Aplysia; Cells, Cultured; Coculture Techniques; Cyclic AMP Response Element-Binding Protein; Cysteine Proteinase Inhibitors; Down-Regulation; FMRFamide; Ganglia; Histones; Long-Term Synaptic Depression; Motor Neurons; Nerve Tissue Proteins; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteins; Repressor Proteins; RNA, Messenger; Synapsins; Synaptosomes; Ubiquitin; Ubiquitin Thiolesterase; Ubiquitination; Up-Regulation | 2008 |
ER stress is the initial response to polyglutamine toxicity in PC12 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 3; Cell Survival; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Enzyme Activation; JNK Mitogen-Activated Protein Kinases; PC12 Cells; Peptides; Polyubiquitin; Proteasome Endopeptidase Complex; Protein Folding; Rats; Recombinant Fusion Proteins; Signal Transduction; Ubiquitination | 2008 |
Proteasome inhibition induces neurite outgrowth through posttranslational modification of TrkA receptor.
Topics: Acetylcysteine; Animals; Cell Differentiation; Cysteine Proteinase Inhibitors; Leupeptins; MAP Kinase Signaling System; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Rats; Receptor, trkA; Ubiquitination | 2009 |
Consequences of the DYT1 mutation on torsinA oligomerization and degradation.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Molecular Chaperones; Mutation; Oligopeptides; Time Factors; Transfection | 2008 |
Structural basis for activation and inhibition of the secreted chlamydia protease CPAF.
Topics: Acetylcysteine; Bacterial Proteins; Chlamydia trachomatis; Crystallography, X-Ray; Dimerization; Enzyme Inhibitors; Humans; Models, Biological; Models, Molecular; Protein Structure, Quaternary; Protein Structure, Tertiary; Protein Subunits; Serine Endopeptidases; Virulence Factors | 2008 |
Characterization of proteasome inhibition on astrocytes cell cycle.
Topics: Acetylcysteine; Animals; Astrocytes; Cell Culture Techniques; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Central Nervous System Diseases; Cysteine Proteinase Inhibitors; Humans; Interleukin-6; Phosphorylation; Proteasome Inhibitors; Rats; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor | 2009 |
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylcysteine; Adenoviridae; Aldosterone; Animals; Biological Transport; Blotting, Western; Cysteine Proteinase Inhibitors; Glucose; Immunoprecipitation; Insulin; Insulin Receptor Substrate Proteins; Leupeptins; Mice; Phosphorylation; Reactive Oxygen Species; Receptor, Insulin; Signal Transduction | 2009 |
Protective effect against Parkinson's disease-related insults through the activation of XBP1.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Cell Death; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dopamine; Endoplasmic Reticulum; Endoribonucleases; Humans; Leupeptins; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neurons; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Regulatory Factor X Transcription Factors; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factors; X-Box Binding Protein 1 | 2009 |
Diastereo- and enantioselective synthesis of beta-hydroxy-alpha-amino acids: application to the synthesis of a key intermediate for lactacystin.
Topics: Acetylcysteine; Aldehydes; Amino Acids; Hydrolysis; Stereoisomerism; Substrate Specificity | 2009 |
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzazepines; Cell Line; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Cyclin D1; Fibroblasts; Glioma; Hexanones; Humans; Hydrocarbons, Chlorinated; Indoles; Leupeptins; Mice; Peptide Fragments; Proteasome Inhibitors; Purines; Recombinant Fusion Proteins; Roscovitine; Threonine | 2009 |
Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion.
Topics: Acetylcysteine; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Embryo Implantation; Female; Humans; Hydatidiform Mole; Immunohistochemistry; In Vitro Techniques; Interleukin-1beta; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Placentation; Pregnancy; RNA Interference; Trophoblasts; Uterine Neoplasms | 2009 |
TGFbeta prevents proteasomal degradation of the cyclin-dependent kinase inhibitor p27kip1 for cell cycle arrest.
Topics: Acetylcysteine; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; G1 Phase; Humans; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; RNA, Small Interfering; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2009 |
Nigral degeneration with inclusion body formation and behavioral changes in rats after proteasomal inhibition.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Behavior, Animal; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Hypokinesia; Inclusion Bodies; Male; Microscopy, Electron, Transmission; Motor Activity; Neurodegenerative Diseases; Neurons; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 2009 |
Hepatitis B virus replication and release are independent of core lysine ubiquitination.
Topics: Acetylcysteine; Animals; Cell Line, Tumor; Cell Nucleolus; DNA, Viral; Gene Expression Regulation, Viral; Hepatitis B virus; Humans; Interferon-alpha; Lysine; Mice; Mutagenesis, Site-Directed; Mutation; Proteasome Endopeptidase Complex; Protein Transport; Ubiquitin; Ubiquitination; Viral Core Proteins; Virion; Virus Replication | 2009 |
Partial inhibition of proteasome activity enhances remyelination after cuprizone-induced demyelination.
Topics: Acetylcysteine; Animals; Corpus Callosum; Cuprizone; Cysteine Proteinase Inhibitors; Demyelinating Diseases; Disease Models, Animal; Gliosis; Male; Mice; Myelin Sheath; Nerve Fibers, Myelinated; Nerve Regeneration; Neurotoxins; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Treatment Outcome | 2009 |
An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity.
Topics: Acetylcysteine; Apoptosis; Autophagy; Cell Line, Tumor; Cytoprotection; Dopamine; Enzyme Inhibitors; Humans; Mitochondria; Nerve Degeneration; Neurons; Phagosomes; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Sirolimus; Time Factors; Tumor Suppressor Protein p53 | 2009 |
Enhanced antigen presentation and CTL activity by transduction of mature rather than immature dendritic cells with octaarginine-modified liposomes.
Topics: Acetylcysteine; Animals; Antigen Presentation; Cysteine Proteinase Inhibitors; Dendritic Cells; Endocytosis; Histocompatibility Antigens Class I; Immunodominant Epitopes; Liposomes; Mice; Mice, Inbred C57BL; Oligopeptides; T-Lymphocytes, Cytotoxic | 2009 |
Efficacy on anaplastic thyroid carcinoma of valproic acid alone or in combination with doxorubicin, a synthetic chenodeoxycholic acid derivative, or lactacystin.
Topics: Acetylcysteine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Survival; Chenodeoxycholic Acid; Dose-Response Relationship, Drug; Doxorubicin; Drug Evaluation, Preclinical; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mitochondria; Thyroid Neoplasms; Treatment Outcome; Tumor Cells, Cultured; Valproic Acid | 2009 |
Targeting transcription factor NFkappaB: comparative analysis of proteasome and IKK inhibitors.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Enzyme Inhibitors; Humans; I-kappa B Kinase; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Tumor Necrosis Factor-alpha | 2009 |
Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.
Topics: Acetylcysteine; Activating Transcription Factor 6; Animals; Apolipoprotein B-100; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoribonucleases; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Glucosamine; Heat-Shock Proteins; Humans; Leupeptins; Membrane Proteins; Phosphorylation; Protein Serine-Threonine Kinases; RNA; Signal Transduction; Time Factors | 2009 |
F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; Cyclin D1; Cysteine Proteinase Inhibitors; DNA Damage; DNA-Binding Proteins; F-Box Proteins; G1 Phase; Humans; Melanoma; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Transcriptional Activation; Tumor Suppressor Proteins; Ubiquitination | 2009 |
Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy.
Topics: Acetylcysteine; Animals; Axons; Axotomy; Cells, Cultured; Cysteine Proteinase Inhibitors; Immunohistochemistry; Leupeptins; Neurofilament Proteins; Neurons; Phosphorylation; Physical Stimulation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Ubiquitin; Ubiquitination | 2009 |
Inhibition of lysosomal functions reduces proteasomal activity.
Topics: Acetylcysteine; alpha-Synuclein; Ammonium Chloride; Autophagy; Blotting, Western; Cell Line, Tumor; Chloroquine; Enzyme Inhibitors; HSC70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Hydrogen-Ion Concentration; Lysosomes; Neurons; Proteasome Endopeptidase Complex | 2009 |
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.
Topics: 3T3-L1 Cells; Acetylcysteine; Animals; Benzoquinones; Cell Membrane; Chloroquine; Endocytosis; Exocytosis; Glucose Transporter Type 1; Glucose Transporter Type 2; Glucose Transporter Type 4; Lactams, Macrocyclic; Lysosomes; Mice | 2009 |
Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Cysteine Proteinase Inhibitors; Endosomes; Fibroblast Growth Factor 1; Humans; Intracellular Membranes; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NIH 3T3 Cells; Protein Structure, Tertiary; Protein Transport; Receptors, Fibroblast Growth Factor; Recombinant Fusion Proteins; Signal Transduction; Thermodynamics | 2009 |
[Dual effects of different concentrations of alpha-synuclein on the neurotoxicity of 6-hydroxydopamine in SH-SY5Y cells].
Topics: Acetylcysteine; alpha-Synuclein; Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Neurons; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinson Disease | 2009 |
Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stability.
Topics: Acetylcysteine; Animals; Biotinylation; Cell Line, Transformed; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Humans; Immunoprecipitation; Membrane Potentials; Models, Molecular; Mutagenesis, Site-Directed; Mutation, Missense; Patch-Clamp Techniques; Protein Transport; Receptors, Glycine; Transfection | 2009 |
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition.
Topics: Acetylcysteine; Aging; Animals; Biomarkers; Caspase 3; Enzyme Inhibitors; Hippocampus; Male; Nerve Degeneration; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Signal Transduction; Unfolded Protein Response | 2009 |
Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria, Liver; Neuroblastoma; Reactive Oxygen Species; Recombinant Fusion Proteins; Tetrazolium Salts; Thiazoles | 2009 |
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.
Topics: Acetylcysteine; Adenine; Analysis of Variance; Autophagy; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Green Fluorescent Proteins; Humans; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Transport; Subcellular Fractions; Transfection; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration.
Topics: Acetylcysteine; Animals; Apoferritins; Cation Transport Proteins; Chelation Therapy; Corpus Striatum; Cysteine Proteinase Inhibitors; Cytoprotection; Dopamine; Gene Expression Regulation; Genetic Therapy; Iron Metabolism Disorders; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra | 2010 |
Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Epithelial Cells; Gene Expression Regulation; Heat Shock Transcription Factors; HSP30 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Proteasome Inhibitors; Temperature; Transcription Factors; Xenopus laevis | 2010 |
Induction of cross-priming of naive CD8+ T lymphocytes by recombinant bacillus Calmette-Guerin that secretes heat shock protein 70-major membrane protein-II fusion protein.
Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; BCG Vaccine; Brefeldin A; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cross-Priming; Dendritic Cells; HSP70 Heat-Shock Proteins; Humans; Interferon-gamma; Interleukin-12; Lymphocyte Activation; Matrix Metalloproteinase 2; Membrane Proteins; Mice; Mice, Inbred C57BL; Recombinant Fusion Proteins; Toll-Like Receptor 2 | 2009 |
Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced Parkinsonian rat model.
Topics: Acetylcysteine; Animals; Antimetabolites; Apomorphine; Behavior, Animal; Blotting, Western; Bone Marrow Transplantation; Bromodeoxyuridine; Cysteine Proteinase Inhibitors; Dopamine; Dopamine Agonists; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Neostriatum; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Tissue Engineering; Tyrosine 3-Monooxygenase | 2010 |
Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Topics: Acetylcysteine; Apoptosis; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Leupeptins; Lysosomes; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Serine-Threonine Kinases | 2010 |
The pattern of neuronal loss and survival may reflect differential expression of proteasome activators in Parkinson's disease.
Topics: Acetylcysteine; Animals; Blotting, Western; Canavanine; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dopamine; Immunohistochemistry; Locus Coeruleus; Male; Nerve Degeneration; Neurons; Oxidative Stress; Parkinson Disease; Proteasome Endopeptidase Complex; Protein Folding; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra; Ubiquitin-Activating Enzymes; Ubiquitin-Conjugating Enzymes; Uncoupling Agents | 2010 |
Hsp40 chaperones promote degradation of the HERG potassium channel.
Topics: Acetylcysteine; Chaperonins; Densitometry; Endoplasmic Reticulum; Ether-A-Go-Go Potassium Channels; HeLa Cells; HSP40 Heat-Shock Proteins; Humans; Long QT Syndrome; Molecular Chaperones; Mutation; Proteasome Inhibitors; Protein Folding | 2010 |
The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.
Topics: Acetylcysteine; Animals; Binding Sites; Brefeldin A; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Glycosylation; Leupeptins; Membrane Transport Modulators; Protein Structure, Tertiary; Protein Transport; Quinones; Sequence Deletion; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sesquiterpenes; Structure-Activity Relationship; Transfection | 2009 |
Pathogenic mutations cause rapid degradation of lysosomal storage disease-related membrane protein CLN6.
Topics: Acetylcysteine; Cell Line; Endoplasmic Reticulum; Half-Life; Humans; Intracellular Space; Lysosomal Storage Diseases; Membrane Proteins; Mutant Proteins; Mutation; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Transport | 2010 |
Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes.
Topics: Acetylcysteine; Aging; Animals; Apoptosis; Astrocytes; Biological Transport; Cathepsin D; Cells, Cultured; Cytosol; Lysosomes; Neurons; Oxidative Stress; Proteasome Inhibitors; Rats; Rats, Wistar; tert-Butylhydroperoxide | 2010 |
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Apomorphine; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Dopamine Agonists; Iron; Magnetic Resonance Imaging; Male; Mesencephalon; Motor Activity; Neurons; Parkinsonian Disorders; Random Allocation; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2010 |
Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasome system in vitro.
Topics: Acetylcysteine; Animals; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Immunohistochemistry; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Oligopeptides; PC12 Cells; Peripheral Nervous System Diseases; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Ubiquitin | 2010 |
Low levels of mutant ubiquitin are degraded by the proteasome in vivo.
Topics: Acetylcysteine; Aging; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Immunohistochemistry; Mice; Mice, Transgenic; Proteasome Endopeptidase Complex; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Proteinase Inhibitors; Ubiquitin | 2010 |
Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.
Topics: Acetylcysteine; Apoptosis; Cell Culture Techniques; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Fibronectins; Humans; Leupeptins; Mutation; Peptide Fragments; Periodontal Ligament; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Transfection; Tumor Suppressor Protein p53; Ubiquitin | 2010 |
Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation.
Topics: Acetylcysteine; Animals; Apoptosis; Boronic Acids; Bortezomib; Cysteine Proteinase Inhibitors; Cytokines; HLA-DR3 Antigen; Lipopolysaccharides; Liver; Mice; Mice, Transgenic; NF-kappa B; Proteasome Inhibitors; Pyrazines; Superantigens; Systemic Inflammatory Response Syndrome | 2010 |
Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes.
Topics: Acetylcysteine; Animals; Cell Separation; Cytokines; DNA; GATA3 Transcription Factor; Humans; Jurkat Cells; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Proteasome Inhibitors; Protein Binding; Spleen; T-Box Domain Proteins; Tetradecanoylphorbol Acetate; Th2 Cells | 2010 |
Regulation of aurora B kinase by the lipid raft protein flotillin-1.
Topics: Acetylcysteine; Anti-Bacterial Agents; Aurora Kinase B; Aurora Kinases; Cell Division; Cell Nucleus; CREST Syndrome; DNA Primers; Down-Regulation; Gene Knockdown Techniques; HeLa Cells; Humans; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Membrane Proteins; Microtubule-Associated Proteins; Oligopeptides; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Survivin; Transfection | 2010 |
Proteasome inhibitor lactacystin induces cholinergic degeneration.
Topics: Acetylcholine; Acetylcysteine; Animals; Annexin A5; Apoptosis; Cell Line, Transformed; Cell Survival; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Membrane Potential, Mitochondrial; Mice; Oxidative Stress; Reactive Oxygen Species; Ubiquitin C | 2010 |
Expression of alternatively spliced CD45 isoforms by channel catfish clonal T and B cells is dependent on activation state of the cell and regulated by protein synthesis and degradation.
Topics: Acetylcysteine; Alternative Splicing; Animals; B-Lymphocytes; Clone Cells; Concanavalin A; Cycloheximide; Feedback, Physiological; Gene Expression Profiling; Ictaluridae; Immunization; Leukocyte Common Antigens; Lymphocyte Activation; Protein Isoforms; T-Lymphocytes | 2010 |
Novel D3 dopamine receptor-preferring agonist D-264: Evidence of neuroprotective property in Parkinson's disease animal models induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and lactacystin.
Topics: Acetylcysteine; Animals; Benzothiazoles; Biphenyl Compounds; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cysteine Proteinase Inhibitors; Dopamine Agonists; Dopamine Antagonists; Enzyme-Linked Immunosorbent Assay; Glial Cell Line-Derived Neurotrophic Factor; Immunohistochemistry; Indans; Locomotion; Male; Mice; Mice, Inbred C57BL; Motor Activity; MPTP Poisoning; Neostriatum; Neuroprotective Agents; Parkinson Disease, Secondary; Piperazines; Postural Balance; Proteasome Endopeptidase Complex; Receptors, Dopamine D3; Thiazoles | 2010 |
Neuroprotection of pramipexole in UPS impairment induced animal model of Parkinson's disease.
Topics: Acetylcysteine; Animals; Autophagy; Benzothiazoles; Brain-Derived Neurotrophic Factor; Corpus Striatum; Dopamine; Dopamine Agonists; Glial Cell Line-Derived Neurotrophic Factor; Male; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; Neurons; Neuroprotective Agents; Parkinson Disease; Pramipexole; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptors, Dopamine D3; Substantia Nigra; Ubiquitin | 2010 |
Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Antigens, Bacterial; Apoptosis Regulatory Proteins; Bacterial Toxins; Caspase 1; Cell Death; Cell Line; Cysteine Proteinase Inhibitors; Female; Inflammation; Macrophages; Proteasome Endopeptidase Complex; Rats | 2010 |
Proteasome inhibition in medaka brain induces the features of Parkinson's disease.
Topics: Acetylcysteine; Animals; Behavior, Animal; Blotting, Western; Brain Chemistry; Cysteine Proteinase Inhibitors; Dopamine; Dyskinesia, Drug-Induced; Immunohistochemistry; Inclusion Bodies; Microscopy, Electron, Transmission; Neurons; Norepinephrine; Oryzias; Oxidopamine; Parkinson Disease, Secondary; Proteasome Inhibitors; Swimming; Sympatholytics; Ubiquitination | 2010 |
Proteasome inhibition modeling nigral neuron degeneration in Parkinson's disease.
Topics: Acetylcysteine; Animals; Behavior, Animal; Blotting, Western; Cell Count; Chromatography, High Pressure Liquid; Dopamine; Fluorescent Antibody Technique; Immunohistochemistry; Iron; Male; Mice; Mice, Inbred C57BL; Microinjections; Microscopy, Electron; Nerve Degeneration; Neurons; Neuroprotective Agents; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Ubiquitin | 2010 |
Cell cycle events mediate lactacystin-induced apoptotic death of neuronal PC12 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Mitogen-Activated Protein Kinase 3; Neurons; PC12 Cells; Rats | 2010 |
Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin.
Topics: Acetylcysteine; Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Gene Expression Profiling; Mice; Microarray Analysis; Neurons; Proteasome Inhibitors; Stress, Physiological; Up-Regulation | 2011 |
Wnt3a regulates tumor necrosis factor-α-stimulated interleukin-6 release in osteoblasts.
Topics: Acetylcysteine; Animals; Cell Line; Enzyme Induction; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; I-kappa B Proteins; Interleukin-6; Lithium Chloride; Macrolides; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Osteoblasts; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Messenger; Tumor Necrosis Factor-alpha; Wnt Proteins; Wnt3 Protein; Wnt3A Protein | 2011 |
Effect of nuclear factor kappa B inhibition on L-NAME-induced hypertension and cardiovascular remodelling.
Topics: Acetylcysteine; Animals; Blood Pressure; Hypertension; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Ventricular Remodeling | 2010 |
Annexin A3 is associated with cell death in lactacystin-mediated neuronal injury.
Topics: Acetylcysteine; Animals; Annexin A3; Cell Death; Cells, Cultured; Cerebral Cortex; Mice; Neurodegenerative Diseases; Neurons; Up-Regulation | 2010 |
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.
Topics: Acetylcysteine; Animals; Biological Assay; Boronic Acids; Bortezomib; Cell Extracts; Cells, Cultured; Chymotrypsin; High-Throughput Screening Assays; Inhibitory Concentration 50; Leupeptins; Mice; Models, Biological; Oligopeptides; Ornithine Decarboxylase; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Time Factors | 2011 |
Does 1-(R)-aminoindan possess neuroprotective properties against experimental Parkinson's disease?
Topics: Acetylcysteine; Animals; Catalase; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Humans; Hydrogen Peroxide; Indans; Male; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; PC12 Cells; Rats; Rats, Sprague-Dawley | 2011 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Line, Tumor; Cerebral Cortex; Cycloheximide; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Lewy Bodies; Neurons; Okadaic Acid; Parkinson Disease; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rabbits; Ubiquitin | 2010 |
Treatment of breast cancer cells with proteasome inhibitor lactacystin increases the level of sensitivity to cell death induced by human immunodeficiency virus type 1.
Topics: Acetylcysteine; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Female; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Polyubiquitin; Proteasome Inhibitors; Receptors, CXCR4; Staining and Labeling; T-Lymphocytes | 2010 |
Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl.
Topics: Acetylcysteine; Cell Line; Chaperonin Containing TCP-1; Cysteine Proteinase Inhibitors; Fibroblasts; Gaucher Disease; Glucosylceramidase; Humans; Molecular Chaperones; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-cbl; RNA, Small Interfering | 2010 |
Tripeptidyl peptidase II serves as an alternative to impaired proteasome to maintain viral growth in the host cells.
Topics: Acetylcysteine; Aminopeptidases; Blotting, Western; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Dose-Response Relationship, Drug; Drug Synergism; Enterovirus B, Human; Enzyme Inhibitors; HeLa Cells; Host-Pathogen Interactions; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Serine Endopeptidases; Virus Replication | 2011 |
The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Autophagy; Brain; Cell Differentiation; Dopamine; Male; Medicine, Korean Traditional; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Neuroprotective Agents; Parkinson Disease; PC12 Cells; Phytotherapy; Plant Extracts; Proteasome Endopeptidase Complex; Proteins; Rabbits; Rats; Ubiquitin | 2011 |
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.
Topics: Acetylcysteine; Actins; Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Disease Models, Animal; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Fibrosis; Kidney Diseases; Leupeptins; Male; Nerve Tissue Proteins; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Ureteral Obstruction | 2011 |
Appraising the roles of CBLL1 and the ubiquitin/proteasome system for flavivirus entry and replication.
Topics: Acetylcysteine; Dengue Virus; Gene Knockdown Techniques; HeLa Cells; Humans; Leupeptins; Listeria monocytogenes; Proteasome Endopeptidase Complex; Proteasome Inhibitors; RNA, Small Interfering; Ubiquitin; Ubiquitin-Protein Ligases; Virus Internalization; Virus Replication; West Nile virus; Yellow fever virus | 2011 |
Long-term aversive taste memory requires insular and amygdala protein degradation.
Topics: Acetylcysteine; Amygdala; Animals; Association Learning; Avoidance Learning; Cerebral Cortex; Cysteine Proteinase Inhibitors; Male; Memory, Long-Term; Nerve Tissue Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Taste; Ubiquitin | 2011 |
Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.
Topics: Acetylcysteine; Analgesics, Opioid; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Leupeptins; Naloxone; Narcotic Antagonists; Pertussis Toxin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Receptor, Muscarinic M3; Receptors, Adrenergic, alpha-2; Receptors, Bradykinin; Receptors, Opioid, delta; Receptors, Opioid, mu; RGS Proteins; Signal Transduction; Time Factors; Ubiquitination | 2011 |
Ammonium chloride and tunicamycin are novel toxins for dopaminergic neurons and induce Parkinson's disease-like phenotypes in medaka fish.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Disease Models, Animal; Dopamine; Nerve Tissue Proteins; Neurons; Neurotoxins; Oryzias; Parkinsonian Disorders; Phenotype; Substantia Nigra; Tunicamycin | 2010 |
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation.
Topics: Acetylcysteine; Amino Acid Substitution; Animals; Calcium Channels, N-Type; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Gene Expression Regulation; Leupeptins; Mutation, Missense; Nerve Tissue Proteins; Neurites; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rabbits; Rats | 2011 |
Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease.
Topics: Acetylcysteine; Animals; Behavior, Animal; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Disease Progression; Male; Mental Disorders; Motor Activity; Parkinson Disease, Secondary; Prognosis; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Substantia Nigra | 2011 |
Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads.
Topics: Acetylcysteine; Alkaline Phosphatase; Animals; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Humans; Mice; Osteoblasts; Osteogenesis; Proteasome Inhibitors; Smad Proteins | 2011 |
Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats.
Topics: Acetylcysteine; Animals; Blotting, Western; Corpus Striatum; Dose-Response Relationship, Drug; Male; Parkinson Disease; Proteasome Inhibitors; Rats; Rats, Wistar; Substantia Nigra | 2011 |
Mitogen-activated protein kinase kinase 1 (MEK1) stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation.
Topics: Acetylcysteine; Amino Acid Substitution; Animals; Benzamides; Cell Differentiation; Cell Line; Cullin Proteins; Cysteine Proteinase Inhibitors; Enzyme Activation; MAP Kinase Kinase 1; Mice; Mice, Knockout; Muscle Proteins; Mutation, Missense; Myoblasts; MyoD Protein; Phosphorylation; Protein Stability; SKP Cullin F-Box Protein Ligases; Ubiquitin-Protein Ligases | 2011 |
LPS-induced formation of immunoproteasomes: TNF-α and nitric oxide production are regulated by altered composition of proteasome-active sites.
Topics: Acetylcysteine; Animals; Blotting, Western; Catalytic Domain; Cell Line; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Gene Expression Regulation; Inflammation Mediators; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Poly I-C; Proteasome Endopeptidase Complex; Protein Subunits; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
[Sleep changes during degeneration of neurons in the substantia nigra induced by inhibitor of proteasomes lactacystin in rats].
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Dopamine; Male; Nerve Tissue Proteins; Neurons; Parkinson Disease, Secondary; Proteasome Inhibitors; Rats; Rats, Wistar; Sleep Stages; Substantia Nigra; Tyrosine 3-Monooxygenase | 2010 |
Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.
Topics: Acetylcysteine; Actins; Animals; Binding Sites; Carotid Artery Injuries; Cells, Cultured; Chromatin Immunoprecipitation; Collagen; Cysteine Proteinase Inhibitors; Disease Models, Animal; DNA Polymerase II; Gels; Gene Expression Regulation; Genotype; Humans; Leupeptins; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nuclear Proteins; Phenotype; Phosphorylation; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Serine; Serum Response Factor; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Vasoconstriction | 2011 |
Functional 20S proteasomes in mature human red blood cells.
Topics: Acetylcysteine; Blood Proteins; Cell Differentiation; Electrophoresis, Gel, Two-Dimensional; Erythrocytes; Fluorescent Antibody Technique; Humans; Membrane Proteins; Microscopy, Atomic Force; Microscopy, Confocal; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Subcellular Fractions | 2011 |
Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Butadienes; Calpain; Caspase 3; Caspase Inhibitors; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Cytoprotection; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Gestational Age; In Situ Nick-End Labeling; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Neuroprotective Agents; Nitriles; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Signal Transduction; Spectrin; Time Factors | 2011 |
Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
Topics: Acetylcysteine; Animals; Anthracenes; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Enzyme Activation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin Receptor Substrate Proteins; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Leupeptins; Mice; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2011 |
Protection of neuronal calcium sensor 1 protein in cells treated with paclitaxel.
Topics: Acetylcysteine; Calcium Signaling; Calpain; Cell Line, Tumor; Humans; Mutation; Neuroblastoma; Neuronal Calcium-Sensor Proteins; Neurons; Neuropeptides; Paclitaxel; Point Mutation; Protease Inhibitors; Protein Isoforms; Signal Transduction; Thermodynamics | 2011 |
[Effect of epigallocatechin gallate on lactacystin-induced PC12 cell injury].
Topics: Acetylcysteine; Animals; Apoptosis; Catechin; Flow Cytometry; PC12 Cells; Rats | 2011 |
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.
Topics: Acetylcysteine; Cell Culture Techniques; Cloning, Molecular; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Gene Expression; Immunoprecipitation; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Leupeptins; Methionine Adenosyltransferase; Oligopeptides; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; S-Adenosylmethionine; Transfection; Ubiquitin | 2011 |
Stereospecific total syntheses of proteasome inhibitors omuralide and lactacystin.
Topics: Acetylcysteine; Apoptosis; Chemistry, Pharmaceutical; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Humans; Lactones; Magnetic Resonance Spectroscopy; Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Stereoisomerism | 2011 |
[Content of chaperon Hsp70 in dopaminergic neurons of the black substance increases in proteasome dysfunstion].
Topics: Acetylcysteine; Aging; Animals; Bacterial Proteins; Biotin; Blotting, Western; Catheterization; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Microinjections; Microscopy, Confocal; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Substantia Nigra; Tyrosine 3-Monooxygenase; Ubiquitin; Up-Regulation | 2011 |
Proteasome inhibitor lactacystin augments natural killer cell cytotoxicity of myeloma via downregulation of HLA class I.
Topics: Acetylcysteine; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; Down-Regulation; Histocompatibility Antigens Class I; Humans; Killer Cells, Natural; Multiple Myeloma; Proteasome Inhibitors | 2011 |
Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Herpesvirus 8, Human; Humans; Leupeptins; Lymphoma, Primary Effusion; NF-kappa B; Nitriles; Oligopeptides; Proteasome Inhibitors; Sulfones; Virus Replication | 2011 |
Effects of proteasome inhibitors on the nucleolar size of porcine oocytes.
Topics: Acetylcysteine; Alpha-Amanitin; Animals; Cell Nucleolus; Cysteine Proteinase Inhibitors; Dactinomycin; Female; Leupeptins; Nuclear Proteins; Oocytes; Proteasome Inhibitors; Swine | 2012 |
Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex.
Topics: Acetylcysteine; Actins; Animals; Cell Proliferation; Chloroquine; Connexin 43; Embryonic Stem Cells; Extracellular Matrix; Fibronectins; Focal Adhesion Kinase 1; Gap Junctions; Glycyrrhetinic Acid; Isoquinolines; Laminin; Mice; Multiprotein Complexes; Neuropeptides; Phosphorylation; Protease Inhibitors; Protein Kinase C; Protein Stability; Proteolysis; Receptors, Laminin; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; RNA, Small Interfering; Zonula Occludens-1 Protein | 2012 |
Adriamycin enhances proteasome-mediated generation of the proapoptotic processed form of MAGE-A4 in hepatoma cells.
Topics: Acetylcysteine; Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Doxorubicin; HEK293 Cells; Humans; Leupeptins; Liver Neoplasms; Neoplasm Proteins; Proteasome Endopeptidase Complex; Ubiquitin | 2011 |
Δ⁹-tetrahydrocannabinol (Δ⁹-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Dronabinol; Herbicides; Humans; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Receptor, Cannabinoid, CB1; Tumor Cells, Cultured; Up-Regulation | 2012 |
A mechanistic study of proteasome inhibition-induced iron misregulation in dopamine neuron degeneration.
Topics: Acetylcysteine; Antigens, CD; Blotting, Western; Cell Line; Cell Survival; Cysteine Proteinase Inhibitors; Dopaminergic Neurons; Ferritins; Genetic Vectors; Humans; Immunoprecipitation; Iron; Iron Metabolism Disorders; Iron-Regulatory Proteins; Lentivirus; Nerve Degeneration; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Receptors, Transferrin; RNA, Small Interfering | 2012 |
Presenilin-2 regulates the degradation of RBP-Jk protein through p38 mitogen-activated protein kinase.
Topics: Acetylcysteine; Ammonium Chloride; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Gene Knockout Techniques; HEK293 Cells; Humans; Immunoglobulin J Recombination Signal Sequence-Binding Protein; Leupeptins; Lysosomes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Presenilin-1; Presenilin-2; Proteasome Inhibitors; Proteolysis; Receptor, Notch1; Transcription, Genetic; Transcriptional Activation; Ubiquitination | 2012 |
Proteasomal inhibition restores biological function of mis-sense mutated dysferlin in patient-derived muscle cells.
Topics: Acetylcysteine; Alleles; Amino Acid Substitution; Antineoplastic Agents; Boronic Acids; Bortezomib; Cells, Cultured; Cysteine Proteinase Inhibitors; Distal Myopathies; Dysferlin; Humans; Membrane Proteins; Muscle Fibers, Skeletal; Muscle Proteins; Muscular Atrophy; Muscular Dystrophies, Limb-Girdle; Mutation, Missense; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; RNA, Messenger | 2012 |
Effects of phosphatase and proteasome inhibitors on Borealin phosphorylation and degradation.
Topics: Acetylcysteine; Amino Acid Substitution; CDC2 Protein Kinase; Cell Cycle Proteins; Dual-Specificity Phosphatases; Gene Expression; HeLa Cells; Humans; Leupeptins; Okadaic Acid; Peptide Fragments; Phosphoric Monoester Hydrolases; Phosphorylation; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Ubiquitin | 2012 |
Diltiazem enhances the apoptotic effects of proteasome inhibitors to induce prostate cancer cell death.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Calcium; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Humans; Male; Prostatic Neoplasms; Protease Inhibitors; Pyrazines; Transfection; Tumor Cells, Cultured | 2012 |
The effect of the NF-kappa B inhibitors curcumin and lactacystin on myogenic differentiation of rhabdomyosarcoma cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Muscle Development; Myoblasts; NF-kappa B; Phosphorylation; Rhabdomyosarcoma; Signal Transduction | 2012 |
Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease.
Topics: Acetylcysteine; Animals; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; Neostriatum; Nuclear Receptor Subfamily 4, Group A, Member 2; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Real-Time Polymerase Chain Reaction; RNA, Messenger; Substantia Nigra; Transcriptional Activation; Vesicular Monoamine Transport Proteins | 2012 |
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus.
Topics: Acetylcysteine; Aging; Animals; Drug Synergism; Hippocampus; Inflammation; Lipopolysaccharides; Male; Nerve Degeneration; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Wistar; Ubiquitination | 2012 |
Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.
Topics: Acetylcysteine; Animals; Axons; Cells, Cultured; Endosomal Sorting Complexes Required for Transport; Ganglia, Spinal; Male; Nedd4 Ubiquitin Protein Ligases; Nerve Regeneration; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sciatic Nerve; Ubiquitin-Protein Ligases; Xenopus Proteins | 2012 |
Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Blotting, Western; Cells, Cultured; Cysteine Proteinase Inhibitors; Immunohistochemistry; Lewy Body Disease; Neurons; Neuropeptides; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Synapses; Synaptophysin; Tubulin; Ubiquitination | 2012 |
High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.
Topics: Acetylcysteine; Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Resistance; Embryonic Stem Cells; Gene Expression Regulation, Developmental; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Mice; Oligopeptides; Pluripotent Stem Cells; Proteasome Inhibitors | 2012 |
Chaperones, but not oxidized proteins, are ubiquitinated after oxidative stress.
Topics: Acetylcysteine; Cell Line, Tumor; Cytoskeleton; Energy Metabolism; Humans; Hydrogen Peroxide; Molecular Chaperones; Oxidation-Reduction; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Ubiquitin; Ubiquitinated Proteins; Ubiquitination | 2012 |
Proteasome inhibition decreases inflammation in human endothelial cells exposed to lipopolysaccharide.
Topics: Acetylcysteine; Electrophoresis, Gel, Two-Dimensional; Enzyme-Linked Immunosorbent Assay; GTP-Binding Protein beta Subunits; Heterogeneous-Nuclear Ribonucleoprotein K; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ribonucleoproteins; Up-Regulation | 2012 |
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
Topics: Acetylcysteine; Cell Survival; Cells, Cultured; Enzyme Induction; Gene Expression; Gene Knockdown Techniques; Heme Oxygenase-1; Histone Deacetylase 6; Histone Deacetylases; Homeostasis; HSP70 Heat-Shock Proteins; Humans; Imidazoles; MAP Kinase Signaling System; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyridines; RNA, Small Interfering; Ubiquitin-Activating Enzymes | 2012 |
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
Topics: Acetylcysteine; Aminopeptidases; Antigens, Neoplasm; Autophagy; Cell Line, Tumor; Epitopes; Fibroblasts; HLA-A24 Antigen; Humans; Leukemia; Molecular Mimicry; Pancreatic Neoplasms; Recombinant Proteins; RNA Interference; T-Lymphocytes, Cytotoxic; Vacuoles | 2012 |
Proteotoxic stress induced by Autographa californica nucleopolyhedrovirus infection of Spodoptera frugiperda Sf9 cells.
Topics: Acetylcysteine; Adenine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA Replication; DNA, Viral; HSC70 Heat-Shock Proteins; Lysosomes; Moths; Nucleopolyhedroviruses; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sf9 Cells; Spodoptera; Ubiquitinated Proteins; Ubiquitination; Virus Replication | 2013 |
[Immunohistochemical study of CART-peptide in striato-nigral projections at dopamine loss].
Topics: Acetylcysteine; alpha-Methyltyrosine; Animals; Corpus Striatum; Cysteine Proteinase Inhibitors; Dopamine; Dopaminergic Neurons; Immunohistochemistry; Male; Nerve Tissue Proteins; Nucleus Accumbens; Peptide Fragments; Rats; Rats, Wistar; Substantia Nigra | 2012 |
The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
Topics: Acetylcysteine; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Drug Interactions; Humans; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Rotenone; Time Factors; Tretinoin; Triterpenes | 2013 |
Purification of large cytosolic proteases for in vitro assays: 20S and 26S proteasomes.
Topics: Acetylcysteine; Adsorption; Ammonium Sulfate; Blotting, Western; Chemical Fractionation; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Cytosol; Dialysis; Electrophoresis, Polyacrylamide Gel; Enzyme Assays; Erythrocytes; Glycerol; Humans; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ultracentrifugation | 2013 |
Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1α and proteasome-mediated pathways.
Topics: Acetylcysteine; Animals; Aquaporin 5; Cell Hypoxia; Cell Line; Cobalt; Epithelial Cells; Gene Expression; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung; Mice; Oxygen; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Respiratory Mucosa; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Water | 2013 |
Adaptive changes in autophagy after UPS impairment in Parkinson's disease.
Topics: Acetylcysteine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Humans; Male; Membrane Proteins; Mesencephalon; Mice; Mice, Inbred C57BL; Neurons; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Signal Transduction; TOR Serine-Threonine Kinases; Ubiquitin | 2013 |
Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.
Topics: Acetylcysteine; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Chymotrypsin; Cysteine Proteinase Inhibitors; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Humans; Indicators and Reagents; Mass Spectrometry; Oxadiazoles; Proteasome Inhibitors; Structure-Activity Relationship; Trypsin | 2013 |
Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry.
Topics: Acetylcysteine; Analysis of Variance; Animals; Carbon Isotopes; Cell Count; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Hindlimb; Locomotion; Movement Disorders; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tetrabenazine; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study.
Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Glioma; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Proteasome Inhibitors; Rats; RNA, Messenger; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
[Impact on tyrosinase expression and export from endoplasmic reticulum by inhibition of 26S proteasome].
Topics: Acetylcysteine; Adult; Case-Control Studies; Cells, Cultured; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Female; Humans; Male; Melanocytes; Monophenol Monooxygenase; Proteasome Endopeptidase Complex; Vitiligo; Young Adult | 2013 |
The Spodoptera frugiperda effector caspase Sf-caspase-1 becomes unstable following its activation.
Topics: Acetylcysteine; Animals; Blotting, Western; Caspases; Cloning, Molecular; DNA Primers; Enzyme Activation; Enzyme Stability; Flow Cytometry; In Situ Nick-End Labeling; Indoles; Mutagenesis, Site-Directed; Protein Subunits; Sf9 Cells; Spodoptera | 2013 |
Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults.
Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Aging; Animals; Anti-Bacterial Agents; Apoptosis; Dopaminergic Neurons; Nerve Growth Factor; Nerve Tissue Proteins; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase | 2013 |
Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation.
Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Brain; Cell Death; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum; HeLa Cells; Humans; Male; Mice; Molecular Chaperones; Mutation, Missense; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Binding; Protein Denaturation; Protein Structure, Tertiary; Thapsigargin; Ubiquitinated Proteins | 2013 |
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Glucokinase; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leupeptins; Mice; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Single-Cell Analysis; Ubiquitin; Ubiquitination | 2013 |
Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Axonal Transport; Boronic Acids; Bortezomib; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Embryo, Mammalian; Ganglia, Spinal; Microscopy, Electron, Transmission; Microtubules; Neurons; Organ Culture Techniques; Pyrazines; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors | 2013 |
Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells.
Topics: Acetylcysteine; Androstadienes; Cycloheximide; Exons; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Nonsense Mediated mRNA Decay; Phosphatidylinositol 3-Kinases; Phosphorylation; Proteasome Inhibitors; Protein Serine-Threonine Kinases; RNA Helicases; RNA-Binding Proteins; RNA, Small Interfering; Trans-Activators; Transcription Factors; Ubiquitin; Wortmannin | 2014 |
Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Astrocytes; Connexin 43; Down-Regulation; Gap Junctions; JNK Mitogen-Activated Protein Kinases; Leupeptins; Lipopolysaccharides; NF-kappa B; Proteasome Endopeptidase Complex; Proteolysis; Rats; Signal Transduction; Ubiquitination; Ubiquitins | 2013 |
An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antibodies, Monoclonal; Calcium-Binding Proteins; Cell Count; Choline O-Acetyltransferase; Cholinergic Neurons; Cysteine Proteinase Inhibitors; Disease Models, Animal; Forelimb; Functional Laterality; Image Processing, Computer-Assisted; Laser Capture Microdissection; Magnetic Resonance Imaging; Male; Membrane Proteins; Motor Activity; Muscle Proteins; Nerve Degeneration; Parkinson Disease; Pedunculopontine Tegmental Nucleus; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2015 |
Chronic L-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Adrenergic Agents; Animals; Antiparkinson Agents; Apomorphine; Catalepsy; Cysteine Proteinase Inhibitors; Dopamine Agonists; Dose-Response Relationship, Drug; Functional Laterality; Levodopa; Male; Oxidopamine; Rats; Rats, Wistar; Reaction Time; Serotonin; Substantia Nigra | 2014 |
Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms.
Topics: Acetylcysteine; Age Factors; Animals; Caspase 3; Caspase 9; Cells, Cultured; Cysteine Proteinase Inhibitors; Dendrites; Dendritic Spines; Embryo, Mammalian; Enzyme Activation; Excitatory Postsynaptic Potentials; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Reactive Oxygen Species; Signal Transduction; Synapses; Time Factors | 2014 |
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer.
Topics: Acetylcysteine; Animals; Antigen Presentation; Cell Line, Tumor; Cells, Cultured; Cross-Priming; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Dendritic Cells; Flow Cytometry; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Humans; Interferon-gamma; Lipids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Neoplasms; Ovalbumin; Oxidation-Reduction; Peptide Fragments | 2014 |
Hippocampal molecular mechanisms involved in the enhancement of fear extinction caused by exposure to novelty.
Topics: Acetylcysteine; Animals; Anisomycin; Behavior, Animal; Calcium Channel Blockers; Conditioning, Classical; Excitatory Amino Acid Antagonists; Fear; Hippocampus; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Rats; Sirolimus; Ubiquitin | 2014 |
Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.
Topics: Acetaldehyde; Acetylcysteine; Animals; Cell Nucleus; Collagen Type II; Cytosol; DNA-Binding Proteins; Down-Regulation; Fibronectins; Genes, Reporter; Hepatic Stellate Cells; Humans; Mice; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Repressor Proteins; Response Elements; RNA, Messenger; Smad Proteins; Smad3 Protein; Smad4 Protein; Smad7 Protein; Transcription, Genetic; Transforming Growth Factor beta; Up-Regulation | 2014 |
Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease.
Topics: Acetylcysteine; Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Dopamine; Humans; Male; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Parkinson Disease; Pentacyclic Triterpenes; Proteasome Inhibitors; Rats; Rats, Wistar; Substantia Nigra; Triterpenes | 2014 |
Differential protein profile of PC12 cells exposed to proteasomal inhibitor lactacystin.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Death; Cytoplasm; Heat-Shock Proteins; Inclusion Bodies; Parkinson Disease; PC12 Cells; Proteasome Inhibitors; Proteome; Rats; Tyrosine 3-Monooxygenase | 2014 |
Assessment of cytokine-modulated proteasome activity.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Antibodies; Catalytic Domain; Cysteine Proteinase Inhibitors; Cytokines; Fluorescent Dyes; Horseradish Peroxidase; Humans; Immunoassay; Kinetics; Luminescent Measurements; Peptides; Proteasome Endopeptidase Complex; Protein Subunits; Proteolysis; Spectrometry, Fluorescence; Tissue Extracts | 2014 |
Interferon-γ induces immunoproteasomes and the presentation of MHC I-associated peptides on human salivary gland cells.
Topics: Acetylcysteine; Cells, Cultured; Humans; Interferon-gamma; Major Histocompatibility Complex; Mass Spectrometry; Proteasome Endopeptidase Complex; Protein Subunits; Salivary Glands; Up-Regulation | 2014 |
Exogenous protein HSP70 blocks neurodegeneration in the rat model of the clinical stage of Parkinson's disease.
Topics: Acetylcysteine; Animals; HSP70 Heat-Shock Proteins; Male; Neuroprotective Agents; Parkinson Disease, Secondary; Protease Inhibitors; Rats; Rats, Wistar | 2014 |
Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin II.
Topics: Acetylcysteine; Angiotensin II; Brefeldin A; Endoplasmic Reticulum; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Golgi Apparatus; HEK293 Cells; Humans; Indoles; Lysosomes; Macrolides; Maleimides; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Stability; Protein Transport; Proteolysis; Receptor, Angiotensin, Type 1; Signal Transduction; Transfection | 2014 |
α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Death; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Parkinson Disease; Rats, Wistar | 2014 |
Proteasome inhibitor lactacystin enhances cisplatin cytotoxicity by increasing endoplasmic reticulum stress-associated apoptosis in HeLa cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cisplatin; DNA Breaks, Double-Stranded; Drug Synergism; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; HeLa Cells; Humans; Proteasome Inhibitors | 2015 |
Enzyme enhancers for the treatment of Fabry and Pompe disease.
Topics: 1-Deoxynojirimycin; Acetylcysteine; alpha-Galactosidase; alpha-Glucosidases; Ambroxol; Bezafibrate; Enzyme Activators; Fabry Disease; Gene Expression; Glycogen Storage Disease Type II; HEK293 Cells; Humans; Leupeptins; Lysosomes; Pioglitazone; Plasmids; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Recombinant Proteins; Thiazolidinediones; Transfection | 2015 |
Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively.
Topics: Acetylcysteine; Anti-Bacterial Agents; Diterpenes; DNA, Bacterial; Gene Expression Regulation, Bacterial; Phylogeny; Species Specificity; Streptomyces | 2015 |
Application of two direct C(sp3)-H functionalizations for total synthesis of (+)-lactacystin.
Topics: Acetylcysteine; Acylation; Biological Products; Molecular Structure; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrroles; Stereoisomerism | 2015 |
Investigation the mechanism of the apoptosis induced by lactacystin in gastric cancer cells.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; DNA; Humans; NF-kappa B; Stomach Neoplasms | 2015 |
Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Cell Count; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Homovanillic Acid; Locomotion; Male; Muscimol; Neurons; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Rats, Wistar; Receptors, GABA-A; Substantia Nigra | 2015 |
Two waves of proteasome-dependent protein degradation in the hippocampus are required for recognition memory consolidation.
Topics: Acetylcysteine; Animals; CA1 Region, Hippocampal; Hippocampus; Infusions, Intraventricular; Male; Memory Consolidation; Proteasome Endopeptidase Complex; Proteolysis; Rats; Rats, Wistar; Recognition, Psychology; Retention, Psychology | 2015 |
Tyrosine hydroxylase is short-term regulated by the ubiquitin-proteasome system in PC12 cells and hypothalamic and brainstem neurons from spontaneously hypertensive rats: possible implications in hypertension.
Topics: Acetylcysteine; Animals; Brain Stem; Hypertension; Hypothalamus; Male; Neurons; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Inbred SHR; Rats, Wistar; Tyrosine 3-Monooxygenase; Ubiquitin | 2015 |
Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor.
Topics: Acetylcysteine; Amino Acid Sequence; Animals; Heterogeneous-Nuclear Ribonucleoproteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mutation; PC12 Cells; Protein Stability; Rats; RNA Splicing; Transforming Growth Factor beta1; Tumor Cells, Cultured | 2015 |
Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Cell Count; Choline O-Acetyltransferase; Cholinergic Neurons; Disease Models, Animal; Dopaminergic Neurons; Male; Microglia; Neurons; Parkinson Disease; Parkinsonian Disorders; Pars Compacta; Pedunculopontine Tegmental Nucleus; Protein Aggregation, Pathological; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 2016 |
Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors.
Topics: Acetylation; Acetylcysteine; Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopaminergic Neurons; Glial Cell Line-Derived Neurotrophic Factor; Histone Deacetylase Inhibitors; Histones; Male; Neuroprotective Agents; Parkinson Disease; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Up-Regulation; Valproic Acid | 2015 |
Characterisation of 20S Proteasome in Tritrichomonas foetus and Its Role during the Cell Cycle and Transformation into Endoflagellar Form.
Topics: Acetylcysteine; Amino Acid Sequence; Blotting, Western; Cell Cycle; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Flagella; Life Cycle Stages; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Molecular Sequence Data; Phylogeny; Proteasome Endopeptidase Complex; Protein Subunits; Protozoan Proteins; Sequence Homology, Amino Acid; Spores, Protozoan; Tritrichomonas foetus | 2015 |
The relationship between protein synthesis and protein degradation in object recognition memory.
Topics: Acetylcysteine; Animals; Anisomycin; CA1 Region, Hippocampal; Catheters, Indwelling; Cysteine Proteinase Inhibitors; Male; Neuropsychological Tests; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proteolysis; Rats, Wistar; Recognition, Psychology; Ubiquitin | 2015 |
Partial inhibition of the ubiquitin-proteasome system ameliorates cardiac dysfunction following ischemia-reperfusion in the presence of high glucose.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Antioxidants; Autophagy; Diabetic Cardiomyopathies; Hyperglycemia; Inflammation Mediators; Isolated Heart Preparation; Leupeptins; Male; Myocardial Reperfusion Injury; Myocardium; Proteasome Inhibitors; Rats, Wistar; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors | 2015 |
G2019S LRRK2 and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system.
Topics: Acetylcysteine; Aging; Animals; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dopaminergic Neurons; Genetic Predisposition to Disease; Mice, Transgenic; Microglia; Motor Activity; Mutation; Neurodegenerative Diseases; Protein Serine-Threonine Kinases; Substantia Nigra; Tyrosine 3-Monooxygenase | 2015 |
Effect of cisplatin on proteasome activity.
Topics: Acetylcysteine; Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Cysteine Proteinase Inhibitors; Drug Synergism; Humans; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitination | 2015 |
The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Tumor; Colorectal Neoplasms; Cysteine; Gene Expression Regulation, Neoplastic; Glutathione; Humans; MAP Kinase Signaling System; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proteasome Inhibitors; Rats | 2016 |
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Topics: Acetylcysteine; Antigen Presentation; Antigens, Neoplasm; Autophagy; Autophagy-Related Protein 12; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Chloroquine; Dendritic Cells; Endocytosis; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class II; Humans; Immunotherapy, Adoptive; Leupeptins; Lymphocyte Activation; Lysosomal-Associated Membrane Protein 2; Melanoma; Membrane Proteins; RNA Interference; RNA, Small Interfering; Small Ubiquitin-Related Modifier Proteins | 2016 |
GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.
Topics: Acetylcysteine; Animals; Central Nervous System; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Expression Regulation, Developmental; Glial Cell Line-Derived Neurotrophic Factor; Humans; Kidney; Mice; Neostriatum; Neuroprotective Agents; Parkinson Disease, Secondary; Substantia Nigra | 2015 |
Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate.
Topics: Acetylcysteine; Animals; Dopaminergic Neurons; Male; Neuroprotective Agents; Parkinsonian Disorders; Proteasome Inhibitors; Rats, Sprague-Dawley; Substantia Nigra; Valproic Acid; Ventral Tegmental Area | 2016 |
NMDAR-dependent proteasome activity in the gustatory cortex is necessary for conditioned taste aversion.
Topics: Acetylcysteine; Animals; Avoidance Learning; Conditioning, Psychological; Cysteine Proteinase Inhibitors; Excitatory Amino Acid Antagonists; Male; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Taste; Taste Perception; Valine | 2016 |
Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation.
Topics: Acetylcysteine; Bacterial Proteins; beta Catenin; Blotting, Western; Cell Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Epithelial Cells; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Integrin beta1; Lectins; Microscopy, Confocal; Proteasome Endopeptidase Complex; Proteolysis; Recombinant Proteins; Transcription Factor RelA; Wnt Signaling Pathway | 2016 |
Early increase in dopamine release in the ipsilateral striatum after unilateral intranigral administration of lactacystin produces spontaneous contralateral rotations in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Amphetamine; Animals; Benzazepines; Central Nervous System Agents; Corpus Striatum; Dopamine; Dopamine Antagonists; Functional Laterality; Glutamic Acid; Haloperidol; Homovanillic Acid; Male; Movement; Parkinsonian Disorders; Rats, Wistar; Receptors, Dopamine; Rotation; Substantia Nigra | 2016 |
The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.
Topics: Acetylcysteine; Amino Acid Substitution; Animals; Dogs; HEK293 Cells; Humans; Madin Darby Canine Kidney Cells; Monocarboxylic Acid Transporters; Proteasome Endopeptidase Complex; Protein Multimerization; Protein Processing, Post-Translational; Symporters; Ubiquitin | 2016 |
The effect of peptidic and non-peptidic proteasome inhibitors on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype.
Topics: Acanthamoeba castellanii; Acetylcysteine; Bortezomib; Brain; Cell Adhesion; Cells, Cultured; Chlorhexidine; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Genotype; Humans; Lactones; Leupeptins; Proteasome Inhibitors | 2016 |
The effects of proteasomal inhibition on synaptic proteostasis.
Topics: Acetylcysteine; Animals; Cells, Cultured; Female; Male; Nerve Tissue Proteins; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Proteolysis; Rats, Wistar; Synapses; Ubiquitin | 2016 |
Determination of differentially regulated proteins upon proteasome inhibition in AML cell lines by the combination of large-scale and targeted quantitative proteomics.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Bortezomib; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Ontology; Heat-Shock Proteins; Humans; Interleukins; Leukocytes; Leupeptins; Molecular Sequence Annotation; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Signal Transduction; Transcription Factors; Tumor Suppressor Protein p53 | 2017 |
Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture.
Topics: Acetylcysteine; alpha-Synuclein; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Mutation; Proline; Prolyl Oligopeptidases; Proteasome Inhibitors; Protein Aggregates; Serine Endopeptidases; Serine Proteinase Inhibitors | 2017 |
The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA.
Topics: Acetylcysteine; Amphetamine; Animals; Apomorphine; Benzazepines; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Functional Laterality; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Pars Compacta; Raclopride; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Rotation | 2017 |
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Plastic changes at corticostriatal synapses predict improved motor function in a partial lesion model of Parkinson's disease.
Topics: Acetylcysteine; Animals; Behavior, Animal; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Male; Mice, Inbred C57BL; Motor Activity; Neural Pathways; Neuronal Plasticity; Parkinson Disease; Parkinsonian Disorders; Pars Compacta; Post-Synaptic Density; Rotarod Performance Test; Synapses | 2017 |
Caloric Restriction Protects against Lactacystin-Induced Degeneration of Dopamine Neurons Independent of the Ghrelin Receptor.
Topics: Acetylcysteine; Age Factors; Animals; Caloric Restriction; Cell Count; Dopaminergic Neurons; Male; Mice; Mice, Knockout; Neuroprotective Agents; Receptors, Ghrelin; Substantia Nigra | 2017 |
Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse.
Topics: Acetylcysteine; Age Factors; Animals; Calcium-Binding Proteins; Cysteine Proteinase Inhibitors; Disease Models, Animal; Forelimb; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microinjections; Neuroglia; Neurotransmitter Agents; Parkinson Disease; Psychomotor Performance; Substantia Nigra; Synucleins; Tyrosine 3-Monooxygenase | 2017 |
[
Topics: Acetylcysteine; Animals; Brain; Disease Models, Animal; Fluorine Radioisotopes; Image Processing, Computer-Assisted; Male; Parkinson Disease; Rats; Rats, Sprague-Dawley; Tetrabenazine | 2017 |
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Captopril; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension; Light; Male; Melatonin; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Ventricular Remodeling | 2017 |
Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.
Topics: Acetylcysteine; Amyloid beta-Peptides; Animals; Cathepsin B; Cysteine Proteinase Inhibitors; Hippocampus; Lysosomes; Neurons; Peptide Fragments; Phosphorylation; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Synaptophysin; tau Proteins | 2017 |
FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation.
Topics: Acetylcysteine; Cell Membrane; Cell Movement; Endosomes; Endothelial Cells; Guanine Nucleotide Exchange Factors; Humans; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Impairment of non-associative learning in a rat experimental model of preclinical stage of Parkinson's disease.
Topics: Acetylcysteine; Animals; Axons; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Dopaminergic Neurons; Humans; Learning; Mesencephalon; Parkinson Disease, Secondary; Prefrontal Cortex; Rats | 2017 |
KCTD5 and Ubiquitin Proteasome Signaling Are Required for
Topics: Acetylcysteine; Adhesins, Bacterial; Antigens, Bacterial; Bacterial Proteins; Cell Line; Coculture Techniques; Cullin Proteins; Epithelial Cells; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Host-Pathogen Interactions; Humans; Lysosomes; Potassium Channels; Proteasome Endopeptidase Complex; Signal Transduction; Ubiquitin; Virulence Factors | 2017 |
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Erythropoietin; Gene Expression Regulation; Humans; Imidazoles; Interferon-gamma; Kidney; Kidney Transplantation; Lentivirus; MAP Kinase Kinase 4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Rats; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; STAT6 Transcription Factor | 2018 |
Temporal-Spatial Profiling of Pedunculopontine Galanin-Cholinergic Neurons in the Lactacystin Rat Model of Parkinson's Disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Choline O-Acetyltransferase; Cysteine Proteinase Inhibitors; Disease Models, Animal; Galanin; Male; Neurons; Parkinson Disease; Pedunculopontine Tegmental Nucleus; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine 3-Monooxygenase | 2018 |
HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.
Topics: Acetylcysteine; Animals; Animals, Newborn; Cardiomyopathy, Hypertrophic; Carrier Proteins; Cell Nucleus; Gene Knockdown Techniques; Haploinsufficiency; HEK293 Cells; HSC70 Heat-Shock Proteins; Humans; Myocardium; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Proteostasis; Rats; Sarcomeres; Ventricular Septum | 2018 |
Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells.
Topics: Acetylcysteine; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Down-Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Insulin-Secreting Cells; Insulinoma; Islet Amyloid Polypeptide; Leupeptins; Mice; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2018 |
The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Analysis of Variance; Animals; Brain; Brain Injuries; Cysteine Proteinase Inhibitors; Dopamine; Exploratory Behavior; Functional Laterality; Locomotion; Male; Microdialysis; Neuroprotective Agents; Rats; Rats, Wistar; Tetrahydroisoquinolines | 2018 |
[EFFECT OF QUERCETIN ON NEURODEGENERATIVE AND COMPENSATORY PROCESSES IN NIGROSTRIATAL SYSTEM IN A MODEL OF PRECLINICAL PARKINSON''S DISEASE STAGE IN RATS].
Topics: Acetylcysteine; Animals; Corpus Striatum; Dopaminergic Neurons; HSP70 Heat-Shock Proteins; Male; Neurodegenerative Diseases; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Quercetin; Rats; Rats, Wistar; Substantia Nigra | 2016 |
Regulation of cell surface protease receptor S100A10 by retinoic acid therapy in acute promyelocytic leukemia (APL)
Topics: Acetylcysteine; Animals; Annexin A2; Antineoplastic Agents; Cell Line, Tumor; HEK293 Cells; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; MCF-7 Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; S100 Proteins; Tretinoin; U937 Cells; Ubiquitination | 2018 |
The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease.
Topics: Acetylation; Acetylcysteine; Animals; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Histone Deacetylase Inhibitors; Male; Nerve Degeneration; Niacinamide; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley | 2019 |
Longitudinal monoaminergic PET imaging of chronic proteasome inhibition in minipigs.
Topics: Acetylcysteine; Animals; Biogenic Monoamines; Cysteine Proteinase Inhibitors; Parkinson Disease; Positron-Emission Tomography; Proteasome Endopeptidase Complex; Radioligand Assay; Swine; Swine, Miniature; Time Factors | 2018 |
Roles of the proteasome and inhibitor of DNA binding 1 protein in myoblast differentiation.
Topics: Acetylcysteine; Animals; Cattle; Cell Differentiation; Cycloheximide; Gene Expression Regulation, Developmental; Inhibitor of Differentiation Protein 1; Male; Muscle Proteins; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Messenger; Satellite Cells, Skeletal Muscle; Sequence Analysis, RNA; Ubiquitination | 2019 |
A Functional Ubiquitin-Proteasome System is Required for Efficient Replication of New World Mayaro and Una Alphaviruses.
Topics: Acetylcysteine; Alphavirus; Animals; Antiviral Agents; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Cytoplasm; HeLa Cells; Humans; Leupeptins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Vero Cells; Virus Replication | 2019 |
The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Ducks; Flavivirus; Gene Knockdown Techniques; Leupeptins; Poultry Diseases; Proteasome Endopeptidase Complex; RNA, Small Interfering; Transfection; Ubiquitin; Viral Envelope Proteins; Virus Internalization; Virus Replication | 2019 |
Proteasomal Inhibition Redirects the PrP-Like Shadoo Protein to the Nucleus.
Topics: Acetylcysteine; Animals; Autophagy; Cell Line, Tumor; Cell Nucleus; GPI-Linked Proteins; Humans; Leupeptins; Mice, Knockout; Models, Biological; Nerve Tissue Proteins; Neuroglia; Neurons; Prions; Promoter Regions, Genetic; Proteasome Inhibitors | 2019 |
Measuring redox effects on the activities of intracellular proteases such as the 20S Proteasome and the Immuno-Proteasome with fluorogenic peptides.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents; Chymotrypsin; Cytoplasm; Humans; Hydrogen Peroxide; Mice; Oxidation-Reduction; Oxidative Stress; Oxygen; Peptide Hydrolases; Peptides; Phenotype; Proteasome Endopeptidase Complex; Trypsin | 2019 |
Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington's disease.
Topics: Acetylcysteine; Biocatalysis; Cell Survival; Cysteine Proteinase Inhibitors; HeLa Cells; Humans; Huntingtin Protein; Huntington Disease; Peptides; Proline; Prolyl Oligopeptidases; Proteasome Endopeptidase Complex; Protein Aggregates; Protein Aggregation, Pathological; Serine Endopeptidases; Trinucleotide Repeats | 2019 |
Systemic LPS-induced neuroinflammation increases the susceptibility for proteasome inhibition-induced degeneration of the nigrostriatal pathway.
Topics: Acetylcysteine; Animals; Behavior, Animal; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Illness Behavior; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neural Pathways; Proteasome Inhibitors; Substantia Nigra | 2019 |
C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner.
Topics: Acetylcysteine; Animals; Autophagosomes; Autophagy; C9orf72 Protein; Cell Line; Gene Expression Regulation; Gene Knockout Techniques; Macrolides; Mice; Neurons; Organ Specificity; Proteasome Endopeptidase Complex; Proteolysis; Sirolimus | 2019 |
Novel 1-hydroxypyridin-2-one metal chelators prevent and rescue ubiquitin proteasomal-related neuronal injury in an in vitro model of Parkinson's disease.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Dopamine; Dopaminergic Neurons; Humans; Iron; Iron Chelating Agents; Neuroprotective Agents; Parkinson Disease; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Ubiquitin | 2020 |
HDAC6-mediated Hsp90 deacetylation reduces aggregation and toxicity of the protein alpha-synuclein by regulating chaperone-mediated autophagy.
Topics: Acetylcysteine; alpha-Synuclein; Animals; Chaperone-Mediated Autophagy; Histone Deacetylase 6; HSP90 Heat-Shock Proteins; Humans; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Protein Aggregates | 2021 |
CMIP interacts with WT1 and targets it on the proteasome degradation pathway.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Animals; Down-Regulation; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Nephrotic Syndrome; NF-kappa B; Podocytes; Proteasome Endopeptidase Complex; Protein Binding; Proteinuria; RNA Interference; RNA, Small Interfering; Transcriptional Activation; WT1 Proteins | 2021 |