acetylcysteine has been researched along with glutamic acid in 82 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (14.63) | 18.2507 |
| 2000's | 16 (19.51) | 29.6817 |
| 2010's | 32 (39.02) | 24.3611 |
| 2020's | 22 (26.83) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Dröge, W; Eck, HP; Mihm, S | 1 |
| Bristol, LA; Brown, RH; Hosler, B; Kuncl, RW; Rothstein, JD | 1 |
| Mayer, M; Noble, M | 1 |
| Mayer-Próschel, M; Noble, M | 1 |
| Bärtsch, P; Dröge, W; Edler, L; Fischbach, T; Friedmann, B; Hack, V; Kinscherf, R; Weiss, C | 1 |
| Bacskai, B; Pleasure, D; Yoshioka, A | 1 |
| Han, D; Packer, L; Roy, S; Sen, CK | 1 |
| Duval, D; Froissard, P; Monrocq, H | 1 |
| Han, D; Kobayashi, MS; Packer, L; Roy, S; Sen, CK; Tritschler, HJ | 1 |
| Higuchi, Y; Matsukawa, S | 1 |
| Berns, CM; Chen, JC; Corry, PM; Davis, BH; Galoforo, SS; Lee, YJ; Sim, JE; Spitz, DR | 1 |
| Funato, H; Kohsaka, S; Mochizuki, H; Shimojo, M; Takasugi, K; Yamamoto, I | 1 |
| Brera, B; de Ceballos, ML; Fernández-Tomé, MP | 1 |
| Antolín, I; Herrera, F; Martín, V; Mayo, JC; Rodriguez, C; Sainz, RM | 1 |
| Allin, SM; Andrews, DM; Bulman Page, PC; Hamzah, AS; Leach, DC; Rassias, GA | 1 |
| Himi, T; Ikeda, M; Murota, SI; Yasuhara, T | 1 |
| Baker, DA; Kalivas, PW; Lake, RW; McFarland, K; Shen, H; Tang, XC; Toda, S | 1 |
| Behar, TN; Colton, CA | 1 |
| Choi, DH; Jung, EB; Kim, MS; Kim, TY; Lee, J; Moon, SK; Park, C; Park, R | 1 |
| Andreoni, S; Appollonio, I; Begni, B; Beretta, S; Brighina, L; Ferrarese, C; Fumagalli, L; Isella, V; Malaplate-Armand, C; Oster, T; Sirtori, E | 1 |
| Banks, WA; Ercal, N; Goldstein, G; Mare, S; Penugonda, S | 1 |
| Halliwell, B; Hyun, DH; Jenner, P; Lee, M | 1 |
| Hazell, AS; Hoover, R; McIntosh, TK; Yi, JH | 1 |
| Banks, WA; Ercal, N; Lutz, P; Mare, S; Penugonda, S | 1 |
| Baker, DA; Haroutunian, V; Kristiansen, LV; Madayag, A; Meador-Woodruff, JH; Raju, I | 1 |
| Amonpatumrat, S; Kanai, Y; Khunweeraphong, N; Nagamori, S; Piyachaturawat, P; Sakurai, H; Tanaka, H; Wiriyasermkul, P | 1 |
| Huang, KF; Huang, WT; Lin, MT; Niu, KC | 1 |
| Ercal, N; Penugonda, S | 1 |
| Carr, DB; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE; Shen, H; Zhou, W | 1 |
| Abi-Dargham, A; Easwaramoorthy, B; Girgis, RR; Kumar, D; Miyake, N; Skinbjerg, M; Slifstein, M; Xu, X | 1 |
| Do, PH; Kalivas, PW; Moussawi, K; Reichel, CM; See, RE | 1 |
| Cuenod, M; das Neves Duarte, JM; Do, KQ; Gholam-Razaee, MM; Gruetter, R; Kulak, A | 1 |
| Kalivas, BC; Kalivas, PW; Kolokithas, R; Kupchik, YM; Moussawi, K; Ogburn, KB; Tang, XC; Wang, X | 1 |
| Goudriaan, AE; Nederveen, A; Schmaal, L; van den Brink, W; Veltman, DJ | 1 |
| Berk, M; Das, P; Dean, OM; Dodd, S; Fritz, K; Malhi, GS; Tanious, M | 1 |
| Brown, RM; Kalivas, PW; Kupchik, YM | 1 |
| Langlois, X; Schmidt, M; Staelens, S; Stroobants, S; Verhaeghe, J; Wyckhuys, T; Wyffels, L | 1 |
| Chen, S; Goydos, JS; Haffty, B; Khan, A; Schiff, D; Shin, SS; Sierra, J; Wall, BA; Wangari-Talbot, J; Yu, LJ | 1 |
| Balleine, BW; Chieng, BC; Corbit, LH | 1 |
| Percinel, I; Yazici, KU | 2 |
| Arnold, B; Berman, SB; Dukes, AA; Holbein, CD; Liu, A; Rajprohat, S; Roy, N; Van Laar, VS | 1 |
| Kalivas, PW; Roberts-Wolfe, DJ | 1 |
| Czarnecka, A; Konieczny, J; Lenda, T | 1 |
| Chamberlain, SR; Grant, JE; Kim, SW; Leppink, EW; Odlaug, BL; Redden, SA | 1 |
| Baker, AL; Berk, M; Carter, G; Dean, OM; Kelly, PJ; McKetin, R; Turner, A | 1 |
| Gipson, CD | 1 |
| Ala, U; Brusa, D; Calautti, E; Magnuson, MA; Neri, F; Oliviero, S; Provero, P; Riganti, C; Saoncella, S; Tassone, B | 1 |
| Andrade Reis, T; da Silveira, DX; Fidalgo, TM; Nocito Echevarria, MA; Ruffo Capatti, G; Siciliano Soares, V | 1 |
| Alcorn, JL; Hays, LR; Levi Bolin, B; Lile, JA; Rayapati, AO; Rush, CR; Stoops, WW | 1 |
| Banaschewski, T; Dijkhuizen, RM; Dittmann, RW; Durston, S; Glennon, JC; Häge, A; K Buitelaar, J; Mechler, K; Murphy, D; Schweinfurth, N; Tactics Consortium, T; Williams, S | 1 |
| Goudriaan, AE; Kaag, AM; Kooi, DP; Schmaal, L; Schulte, M; van den Brink, W; Wiers, RW | 1 |
| Budziszewska, B; Bystrowska, B; Filip, M; Krzyżanowska, W; Pera, J; Pomierny, B; Pomierny-Chamioło, L | 1 |
| Blue, ME; Johnston, MV; Kambhampati, SP; Kannan, RM; Kannan, S; Nance, E; Singh, S; Smith, ES; Zhang, F; Zhang, Z | 1 |
| Barker, GJ; Collier, T; Egerton, A; Lally, J; Lythgoe, DJ; MacCabe, JH; McGuire, P; McQueen, G; Stone, JM; Zelaya, F | 1 |
| Fukuyama, K; Hasegawa, T; Okada, M | 1 |
| Allen, NP; Del Franco, AP; Gipson, CD; Goenaga, J; Leyrer-Jackson, JM; McClure, EA; Namba, MD; Olive, MF; Piña, J; Powell, GL; Schwartz, D; Spencer, S; Stankeviciute, N | 1 |
| Abi-Dargham, A; Baker, S; Gil, R; Girgis, RR; Gu, M; Javitt, DC; Kantrowitz, JT; Kegeles, LS; Mao, X; Ojeil, N; Shungu, DC; Spielman, DM; Xu, X | 1 |
| Caffino, L; Cervo, L; Di Clemente, A; Fumagalli, F; Giannotti, G; Marzo, CM; Moro, F | 1 |
| Garcia-Keller, C; Gipson, CD; Goenaga, JG; Hogue, IB; Kupchik, YM; Namba, MD; Powell, GL; Spencer, SM; Vicino, IA | 1 |
| Brown, TR; Jenkins, DD; Kalivas, P; Moss, HG; Ward, P | 1 |
| Greenwald, MK; Khatib, D; Lundahl, LH; Stanley, JA; Woodcock, EA | 1 |
| Kim, JE; Park, H | 1 |
| Chen, MC; Hsu, CY; Hsu, LL; Lee, HC; Tseng, LM; Wang, SF | 1 |
| Furlong, TM; Gibson, AS; Keefe, KA | 1 |
| Hays, LR; Lile, JA; Rayapati, AO; Rush, CR; Stoops, WW; Strickland, JC | 1 |
| D'Acunto, CW; Gonzalez, G; Grúz, J; Kaňovský, P; Strnad, M | 1 |
| Baek, JY; Chin, YW; Jung, K; Kang, KS; Kim, HY; Kim, YM | 1 |
| Adler, CM; Blom, TJ; Cecil, KM; DelBello, MP; Nery, FG; Patino, LR; Tallman, MJ | 1 |
| Cleal, JK; Garbis, SD; Lewis, RM; Lofthouse, EM; Manousopoulou, A; O'Kelly, IM; Poore, KR | 1 |
| Boendermaker, WJ; Goudriaan, AE; Schulte, MHJ; van den Brink, W; Wiers, RW | 1 |
| Bains, JS; Borgland, SL; Gordon, GR; Kaur, M; Lau, BK; Murphy-Royal, C; Qiao, M | 1 |
| Fujinaga, M; Hiraishi, A; Kurihara, Y; Mori, W; Nengaki, N; Okada, M; Wakizaka, H; Yamasaki, T; Zhang, MR; Zhang, Y | 1 |
| Green, MF; Hellemann, G; Lee, J; Maddock, RJ; Marder, SR; Yang, YS; Zhang, H | 1 |
| Ge, P; Meng, H; Wang, X; Yu, M; Zhang, W | 1 |
| Blum, AW; Grant, JE | 1 |
| Balleine, BW; Becchi, S; Borgland, SL; Corbit, LH; Hood, J; Kendig, MD; Mohammadkhani, A; Shipman, ML | 1 |
| Akinlolu, A; Emojevwe, V; Igandan, A; Ilesanmi, J; Owolabi, R; Uwejigho, R | 1 |
| Brady, KT; Browning, BD; Ferguson, PL; Gray, KM; Green, R; Kirkland, AE; Liu, H; Maralit, AM; Meyerhoff, DJ; Miranda, R; Prisciandaro, JJ; Squeglia, LM; Tomko, RL | 1 |
| Engeli, EJE; Esposito, F; Herdener, M; Hock, A; Hulka, LM; Kirschner, M; Ponticorvo, S; Preller, KH; Quednow, BB; Russo, AG; Seifritz, E; Zoelch, N | 1 |
5 review(s) available for acetylcysteine and glutamic acid
| Article | Year |
|---|---|
HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine.
Topics: Acetylcysteine; Cysteine; Cystine; Glutamates; Glutamic Acid; Glutathione; HIV; HIV Infections; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxygen; Palliative Care; Superoxides; T-Lymphocytes | 1992 |
On the track of cell survival pharmaceuticals in the oligodendrocyte type-2 astrocyte lineage.
Topics: Acetylcysteine; Animals; Cell Line; Cell Survival; Drug Design; Glutamic Acid; Humans; Nerve Growth Factors; Neuroprotective Agents; Oligodendroglia; Tumor Necrosis Factor-alpha | 1996 |
Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders.
Topics: Acetylcysteine; Animals; Ceftriaxone; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Neurotransmitter Uptake Inhibitors; Substance-Related Disorders | 2015 |
N-acetylcysteine for treating cocaine addiction - A systematic review.
Topics: Acetylcysteine; Animals; Cocaine-Related Disorders; Female; Free Radical Scavengers; Glutamic Acid; Humans; Male; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recurrence; Secondary Prevention; Treatment Outcome | 2017 |
Glutamatergic Agents in the Treatment of Compulsivity and Impulsivity in Child and Adolescent Psychiatry: a Systematic Review of the Literature.
Topics: Acetylcysteine; Adolescent; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Brain; Child; Corpus Striatum; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Memantine; Obsessive-Compulsive Disorder; Randomized Controlled Trials as Topic; Receptors, Glutamate; Risk Assessment; Treatment Outcome | 2018 |
13 trial(s) available for acetylcysteine and glutamic acid
| Article | Year |
|---|---|
Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine.
Topics: Acetylcysteine; Adult; Aerobiosis; Anaerobiosis; Body Weight; Cachexia; Cystine; Exercise; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Tyrosine | 1996 |
N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study.
Topics: Acetylcysteine; Adult; Cocaine-Related Disorders; Cross-Over Studies; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Pilot Projects | 2012 |
Metabolite profiles in the anterior cingulate cortex of depressed patients differentiate those taking N-acetyl-cysteine versus placebo.
Topics: Acetylcysteine; Aspartic Acid; Depressive Disorder, Major; Double-Blind Method; Female; Free Radical Scavengers; Functional Neuroimaging; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Inositol; Male; Middle Aged; Oxidative Stress | 2013 |
N-Acetylcysteine in the Treatment of Excoriation Disorder: A Randomized Clinical Trial.
Topics: Acetylcysteine; Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Glutamic Acid; Humans; Male; Middle Aged; Nucleus Accumbens; Obsessive-Compulsive Disorder; Self-Injurious Behavior; Skin; Young Adult | 2016 |
The effect of N-acetylcysteine on brain glutamate and gamma-aminobutyric acid concentrations and on smoking cessation: A randomized, double-blind, placebo-controlled trial.
Topics: Acetylcysteine; Adult; Craving; Double-Blind Method; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Male; Smoking Cessation; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2017 |
Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study.
Topics: Acetylcysteine; Adolescent; Adult; Female; Free Radical Scavengers; Glutamic Acid; Glutathione; Gyrus Cinguli; Humans; Male; Middle Aged; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Schizophrenia; Young Adult | 2019 |
N-acetylcysteine reduces cocaine-seeking behavior and anterior cingulate glutamate/glutamine levels among cocaine-dependent individuals.
Topics: Acetylcysteine; Adult; Cocaine-Related Disorders; Cross-Over Studies; Double-Blind Method; Drug-Seeking Behavior; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Reward | 2021 |
Influence of n-acetylcysteine maintenance on the pharmacodynamic effects of oral ethanol.
Topics: Acetylcysteine; Adult; Alcoholism; Blood Pressure; Double-Blind Method; Drug-Seeking Behavior; Ethanol; Female; Free Radical Scavengers; Glutamic Acid; Heart Rate; Humans; Male; Middle Aged; Reinforcement, Psychology; Self Administration; Time Factors; Treatment Outcome; Young Adult | 2020 |
N-acetylcysteine for depression and glutamate changes in the left prefrontal cortex in adolescents and young adults at risk for bipolar disorder: A pilot study.
Topics: Acetylcysteine; Adolescent; Bipolar Disorder; Depression; Glutamic Acid; Humans; Pilot Projects; Prefrontal Cortex; Young Adult | 2022 |
The effect of N-acetylcysteine and working memory training on glutamate concentrations in the dACC and rACC in regular cocaine users - A randomized proof of concept study.
Topics: Acetylcysteine; Adult; Cocaine-Related Disorders; Double-Blind Method; Glutamic Acid; Gyrus Cinguli; Humans; Learning; Male; Memory, Short-Term; Middle Aged; Proof of Concept Study | 2021 |
N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study.
Topics: Acetylcysteine; Glutamic Acid; Glutathione; Humans; Psychotic Disorders; Schizophrenia | 2022 |
N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial.
Topics: Acetylcysteine; Adolescent; Alcohol Drinking; Alcoholism; Double-Blind Method; Ethanol; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Humans; Male | 2023 |
Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and
Topics: Acetylcysteine; Animals; Cocaine; Glutamic Acid; Humans; Magnetic Resonance Imaging; Proton Magnetic Resonance Spectroscopy | 2023 |
64 other study(ies) available for acetylcysteine and glutamic acid
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Anti-Anxiety Agents; Antioxidants; Apoptosis; Base Sequence; Benzodiazepines; Biological Transport; Choline O-Acetyltransferase; Chromans; Ditiocarb; Glutamates; Glutamic Acid; Humans; Molecular Sequence Data; Motor Neurons; Nerve Degeneration; Neurotoxins; Oligonucleotides, Antisense; Organ Culture Techniques; Piperazines; Rats; Spinal Cord; Superoxide Dismutase | 1994 |
N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Death; Cell Survival; Cells, Cultured; Ciliary Neurotrophic Factor; Fibroblasts; Ganglia, Spinal; Glutamates; Glutamic Acid; Models, Biological; Nerve Growth Factors; Nerve Tissue Proteins; Nervous System; Neurons, Afferent; Oligodendroglia; Rats; Tumor Necrosis Factor-alpha | 1994 |
Pathophysiology of oligodendroglial excitotoxicity.
Topics: Acetylcysteine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aurintricarboxylic Acid; Benzothiadiazines; Biological Transport; Calcium; Cell Line; Cell Membrane; DNA Fragmentation; Endodeoxyribonucleases; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Nerve Tissue Proteins; Oligodendroglia; Rats; Receptors, AMPA; RNA, Messenger | 1996 |
Regulation of cellular thiols in human lymphocytes by alpha-lipoic acid: a flow cytometric analysis.
Topics: Acetylcysteine; Caprylates; Cell Size; DNA; Flow Cytometry; Fluorescence; Fluorescent Dyes; Glutamic Acid; Glutamine; Glutathione; Humans; Jurkat Cells; Kinetics; Lymphocytes; Male; Sulfhydryl Compounds; T-Lymphocytes; Thioctic Acid | 1997 |
Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells.
Topics: Acetylcysteine; Animals; Antimetabolites, Antineoplastic; Apoptosis; Buthionine Sulfoximine; Culture Media, Serum-Free; Cycloheximide; Cystine; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Neurons; Oxidative Stress; PC12 Cells; Protein Synthesis Inhibitors; Rats | 1997 |
Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Buthionine Sulfoximine; Cell Survival; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Glutathione; Kinetics; Rats; Thioctic Acid; Tumor Cells, Cultured | 1997 |
Active oxygen-mediated chromosomal 1-2 Mbp giant DNA fragmentation into internucleosomal DNA fragmentation in apoptosis of glioma cells induced by glutamate.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Catalase; Chromosomes; Deferoxamine; DNA Fragmentation; Free Radical Scavengers; Glioma; Glutamic Acid; Glutathione; Hydrogen Peroxide; Iron Chelating Agents; Oxidation-Reduction; Oxygen; Phenanthrolines; Rats; Tumor Cells, Cultured | 1998 |
Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.
Topics: Acetylcysteine; Breast Neoplasms; Carcinoma; Cell Death; Drug Resistance, Multiple; Enzyme Activation; Female; Glucose; Glutamic Acid; Glutamine; Glutathione; Glutathione Disulfide; Humans; Mitogen-Activated Protein Kinase 1; Oxidative Stress; Signal Transduction; Tumor Cells, Cultured | 1998 |
Neuroprotective action of a novel compound--M50463--in primary cultured neurons.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Batrachotoxins; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Neurons; Neuroprotective Agents; Neurotoxins; Nicardipine; Nitroprusside; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Thiazoles; Veratrine; Vitamin E | 1999 |
beta-Amyloid-induced cytotoxicity, peroxide generation and blockade of glutamate uptake in cultured astrocytes.
Topics: Acetylcysteine; Amyloid beta-Peptides; Astrocytes; Catalase; Cell Survival; Cells, Cultured; Dithiothreitol; Dose-Response Relationship, Drug; Free Radicals; Glutamic Acid; Humans; Neurons; Peptide Fragments; Peroxides; Time Factors; Vitamin E | 2001 |
Glutamate induces oxidative stress not mediated by glutamate receptors or cystine transporters: protective effect of melatonin and other antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Brain; Carrier Proteins; Cystine; Glutamic Acid; Glutathione; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Receptors, Glutamate | 2001 |
Short and versatile route to a key intermediate for lactacystin synthesis.
Topics: Acetylcysteine; Acylation; Alkylation; Cyclization; Glutamic Acid; Molecular Structure | 2003 |
Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons.
Topics: Acetylcysteine; Amino Acid Transport System X-AG; Animals; Antioxidants; Aspartic Acid; Cell Death; Cells, Cultured; Dicarboxylic Acids; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Glutathione; Hippocampus; Neurons; Neurotransmitter Uptake Inhibitors; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Reactive Oxygen Species | 2003 |
Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Topics: Acetylcysteine; Adaptation, Physiological; Analysis of Variance; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Corpus Striatum; Cystine; Dose-Response Relationship, Drug; Expectorants; Extinction, Psychological; Extracellular Space; Glutamic Acid; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Recurrence; Reinforcement, Psychology; Self Administration; Substance Withdrawal Syndrome; Time Factors | 2003 |
Redox regulation of neuronal migration in a Down Syndrome model.
Topics: Acetylcysteine; Animals; Chemotaxis; Disease Models, Animal; Dithiothreitol; Down Syndrome; Fetus; Glutamic Acid; Mice; N-Methylaspartate; Neurons; Oxidation-Reduction; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Trisomy | 2003 |
Morphine prevents glutamate-induced death of primary rat neonatal astrocytes through modulation of intracellular redox.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Benzeneacetamides; Benzimidazoles; Bisbenzimidazole; Carbocyanines; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Glutamic Acid; Glutathione; Hydrogen Peroxide; Ion Channels; Microscopy, Fluorescence; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Morphine; Naloxone; Narcotic Antagonists; Neuroglia; Oxidation-Reduction; Oxidative Stress; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123 | 2004 |
Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease.
Topics: Acetylcysteine; Adenosine Triphosphate; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Glutamic Acid; Glutathione; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Survival; Drug Interactions; Glutamic Acid; L-Lactate Dehydrogenase; Lipid Peroxidation; Malondialdehyde; PC12 Cells; Rats; Reactive Oxygen Species; Tetrazolium Salts | 2005 |
Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Aldehydes; Apoptosis; Cell Death; Cell Line, Tumor; Drug Resistance; Enzyme Inhibitors; Genetic Predisposition to Disease; Glutamic Acid; Guanine; Humans; Hydrogen Peroxide; Mutation; Nerve Degeneration; Neurons; Neurotoxins; Oxidative Stress; Parkinsonian Disorders; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Substantia Nigra; Tyrosine; Ubiquitin-Protein Ligases | 2005 |
Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine.
Topics: Acetylcysteine; Adaptor Proteins, Vesicular Transport; Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamic Acid; Hippocampus; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurotoxins; Oxidative Stress; Rats; Rats, Sprague-Dawley; SNARE Proteins; Synaptic Membranes; Synaptic Transmission; Time Factors; Up-Regulation | 2006 |
Potentiation of lead-induced cell death in PC12 cells by glutamate: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Antioxidants; Apoptosis; Calcium Channel Blockers; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Environmental Pollutants; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutathione; Lead; Lead Poisoning; Oxidative Stress; PC12 Cells; Phospholipases A; Protein Kinase C; Rats; Reactive Oxygen Species | 2006 |
Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Free Radical Scavengers; Glutamic Acid; Glycine; Humans; Interpersonal Relations; Male; Maze Learning; Microdialysis; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Xanthenes | 2008 |
L-glutamate enhances methylmercury toxicity by synergistically increasing oxidative stress.
Topics: 2-Aminoadipic Acid; Acetylcysteine; Amino Acid Transport System y+; Animals; Antioxidants; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Environmental Pollutants; Glutamic Acid; Glutathione; HeLa Cells; Humans; Methylmercury Compounds; Mice; Neurons; Oxidative Stress; Rats; Reactive Oxygen Species; Time Factors | 2008 |
Hyperbaric oxygen causes both antiinflammation and antipyresis in rabbits.
Topics: Acetylcysteine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Body Temperature; Dinoprostone; Glutamic Acid; Hydroxyl Radical; Hyperbaric Oxygenation; Hypothalamus; Injections; Interleukin-6; Lipopolysaccharides; Male; Oxygen; Rabbits | 2009 |
Supplement may ease compulsive hair pulling.
Topics: Acetylcysteine; Adolescent; Adult; Aged; Dietary Supplements; Double-Blind Method; Glutamic Acid; Humans; Middle Aged; Randomized Controlled Trials as Topic; Trichotillomania; Young Adult | 2009 |
Comparative evaluation of N-acetylcysteine (NAC) and N-acetylcysteine amide (NACA) on glutamate and lead-induced toxicity in CD-1 mice.
Topics: Acetylcysteine; Animals; Antioxidants; Chelating Agents; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Glutathione Disulfide; Lead; Male; Malondialdehyde; Mice; Phospholipases A2; Reactive Oxygen Species | 2011 |
Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.
Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Cocaine-Related Disorders; Glutamic Acid; Homeostasis; Long-Term Potentiation; Microdialysis; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Secondary Prevention; Signal Transduction; Synaptic Transmission | 2011 |
Imaging changes in glutamate transmission in vivo with the metabotropic glutamate receptor 5 tracer [11C] ABP688 and N-acetylcysteine challenge.
Topics: Acetylcysteine; Animals; Brain; Brain Mapping; Carbon Radioisotopes; Glutamic Acid; Image Processing, Computer-Assisted; Male; Oximes; Papio; Pyridines; Radionuclide Imaging; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tissue Distribution | 2011 |
Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.
Topics: Acetylcysteine; Animals; Cocaine; Cocaine-Related Disorders; Cues; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Homeostasis; Male; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Substance Withdrawal Syndrome | 2011 |
N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development.
Topics: Acetylcysteine; Alanine; Animals; Aspartic Acid; Cerebral Cortex; Disease Models, Animal; Free Radical Scavengers; Glutamate-Cysteine Ligase; Glutamic Acid; Glutamine; Glutathione; Inositol; Lactic Acid; Longitudinal Studies; Magnetic Resonance Spectroscopy; Mice; Mice, Knockout; Schizophrenia | 2012 |
The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
Topics: Acetylcysteine; Animals; Cocaine; Cystine; Drug-Seeking Behavior; Excitatory Postsynaptic Potentials; Free Radical Scavengers; Glutamic Acid; Male; Nucleus Accumbens; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recurrence; Synaptic Transmission | 2012 |
The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy.
Topics: Acetylcysteine; Animals; Brain; Clinical Trials as Topic; Disease Models, Animal; Glutamic Acid; Receptors, Glutamate; Substance-Related Disorders | 2013 |
N-acetylcysteine- and MK-801-induced changes in glutamate levels do not affect in vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain.
Topics: Acetylcysteine; Animals; Brain; Carbon Radioisotopes; Dizocilpine Maleate; Glutamic Acid; Ligands; Oximes; Positron-Emission Tomography; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5 | 2013 |
Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells.
Topics: Acetylcysteine; Apoptosis; Biopsy; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Damage; Gene Knockdown Techniques; Glutamic Acid; Glutathione; Histones; Humans; Intracellular Space; Melanoma; Oxidative Stress; Reactive Oxygen Species; Receptors, Metabotropic Glutamate; Riluzole; Signal Transduction | 2014 |
Effects of repeated cocaine exposure on habit learning and reversal by N-acetylcysteine.
Topics: Acetylcysteine; Animals; Cocaine; Conditioning, Operant; Glutamic Acid; Habits; Male; Membrane Potentials; Neostriatum; Neuronal Plasticity; Rats; Rats, Long-Evans | 2014 |
Glutamatergic dysfunction in skin-picking disorder: treatment of a pediatric patient with N-acetylcysteine.
Topics: Acetylcysteine; Child; Female; Glutamic Acid; Humans; Obsessive-Compulsive Disorder; Self-Injurious Behavior; Skin; Treatment Outcome | 2014 |
The role of glutamatergic dysfunction in treatment-resistant obsessive-compulsive disorder: treatment of an adolescent case with N-acetylcysteine augmentation.
Topics: Acetylcysteine; Adolescent; Female; Glutamic Acid; Humans; Obsessive-Compulsive Disorder; Psychiatric Status Rating Scales | 2014 |
Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy.
Topics: Acetylcysteine; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Chaperonin 60; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Glutamic Acid; GTP Phosphohydrolases; Humans; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mitophagy; Neurons; Oxidative Stress; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transfection; Ubiquitin-Protein Ligases | 2015 |
Early increase in dopamine release in the ipsilateral striatum after unilateral intranigral administration of lactacystin produces spontaneous contralateral rotations in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Amphetamine; Animals; Benzazepines; Central Nervous System Agents; Corpus Striatum; Dopamine; Dopamine Antagonists; Functional Laterality; Glutamic Acid; Haloperidol; Homovanillic Acid; Male; Movement; Parkinsonian Disorders; Rats, Wistar; Receptors, Dopamine; Rotation; Substantia Nigra | 2016 |
A potential role for N-acetylcysteine in the management of methamphetamine dependence.
Topics: Acetylcysteine; Amphetamine-Related Disorders; Antioxidants; Australia; Brain; Glutamic Acid; Humans; Methamphetamine | 2017 |
Treating Addiction: Unraveling the Relationship Between N-acetylcysteine, Glial Glutamate Transport, and Behavior.
Topics: Acetylcysteine; Behavior, Addictive; Glutamic Acid; Humans; Neuroglia | 2016 |
Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Cellular Senescence; Epirubicin; Glutamic Acid; Hyperplasia; Keratin-14; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Radiation Tolerance; Rapamycin-Insensitive Companion of mTOR Protein; Reactive Oxygen Species; Skin; Tetradecanoylphorbol Acetate; Transcriptome; X-Rays | 2017 |
N-Acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order.
Topics: Acetylcysteine; Animals; Attentional Bias; Cocaine; Cocaine-Related Disorders; Cues; Double-Blind Method; Glutamic Acid; Humans; Motivation; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2017 |
Ceftriaxone- and N-acetylcysteine-induced brain tolerance to ischemia: Influence on glutamate levels in focal cerebral ischemia.
Topics: Acetylcysteine; Amino Acid Transport Systems, Acidic; Animals; Astrocytes; Brain Ischemia; Ceftriaxone; Excitatory Amino Acid Transporter 2; Frontal Lobe; Gene Expression Regulation; Glutamic Acid; Hippocampus; Humans; Infarction, Middle Cerebral Artery; Rats; Synaptic Transmission | 2017 |
Dendrimer-mediated delivery of N-acetyl cysteine to microglia in a mouse model of Rett syndrome.
Topics: Acetylcysteine; Animals; Brain; Cytokines; Dendrimers; Disease Models, Animal; Free Radical Scavengers; Gene Expression Regulation; Glutamic Acid; Glutathione; Lipopolysaccharides; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Mutation; Rett Syndrome; Tissue Distribution | 2017 |
Effects of N-acetylcysteine on brain glutamate levels and resting perfusion in schizophrenia.
Topics: Acetylcysteine; Adult; Brain; Caudate Nucleus; Cerebrovascular Circulation; Creatine; Cross-Over Studies; Double-Blind Method; Female; Glutamic Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Proton Magnetic Resonance Spectroscopy; Regional Blood Flow; Rest; Schizophrenia | 2018 |
Cystine/Glutamate Antiporter and Aripiprazole Compensate NMDA Antagonist-Induced Dysfunction of Thalamocortical L-Glutamatergic Transmission.
Topics: Acetylcysteine; Animals; Antiporters; Aripiprazole; Dizocilpine Maleate; Glutamic Acid; Male; Models, Biological; N-Methylaspartate; Perfusion; Prefrontal Cortex; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thalamus | 2018 |
Chronic treatment with N-acetylcysteine decreases extinction responding and reduces cue-induced nicotine-seeking.
Topics: Acetylcysteine; Animals; Cues; Dendritic Spines; Drug-Seeking Behavior; Extinction, Psychological; Glutamic Acid; Male; Neuronal Plasticity; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration | 2019 |
Lasting reduction of nicotine-seeking behavior by chronic N-acetylcysteine during experimental cue-exposure therapy.
Topics: Acetylcysteine; Animals; Behavior, Animal; Cues; Drug-Seeking Behavior; Extinction, Psychological; Free Radical Scavengers; Glutamic Acid; Implosive Therapy; Male; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Receptors, AMPA; Recurrence; Tobacco Use Disorder | 2020 |
Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior.
Topics: Acetylcysteine; Animals; Astrocytes; Conditioning, Psychological; Disease Models, Animal; Drug-Seeking Behavior; Glial Fibrillary Acidic Protein; Glutamic Acid; Male; Nicotine; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Self Administration; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats.
Topics: Acetylcysteine; Analgesics, Opioid; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System; Female; Glutamic Acid; Glutathione; Magnetic Resonance Spectroscopy; Maternal Exposure; Naloxone; Neonatal Abstinence Syndrome; Osmosis; Oxidative Stress; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley | 2020 |
Deletion of P2X7 Receptor Decreases Basal Glutathione Level by Changing Glutamate-Glutamine Cycle and Neutral Amino Acid Transporters.
Topics: Acetylcysteine; Amino Acid Transport System ASC; Amino Acid Transport Systems, Neutral; Animals; Gene Deletion; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Minor Histocompatibility Antigens; Molsidomine; Receptors, Purinergic P2X7 | 2020 |
ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation.
Topics: Acetylcysteine; Amino Acid Transport System y+; AMP-Activated Protein Kinase Kinases; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cell Death; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glucose; Glutamic Acid; Glutathione; Humans; Ketoglutaric Acids; Protein Kinases; Reactive Oxygen Species; RNA, Small Interfering; Sirtuin 3; Sulfasalazine; Up-Regulation | 2020 |
Accelerated habitual learning resulting from L-dopa exposure in rats is prevented by N-acetylcysteine.
Topics: Acetylcysteine; Animals; Antioxidants; Behavior, Addictive; Behavior, Animal; Conditioning, Operant; Dopamine; Dopamine Agents; Glutamic Acid; Habits; Levodopa; Male; Motor Activity; Parkinson Disease; Rats; Rats, Long-Evans | 2020 |
Cytokinin Plant Hormones Have Neuroprotective Activity in In Vitro Models of Parkinson's Disease.
Topics: Acetylcysteine; Caspase 3; Caspase 7; Cell Death; Cell Differentiation; Cell Line, Tumor; Cytokinins; Glutamic Acid; Humans; Isoquinolines; Models, Biological; Neurons; Neuroprotective Agents; Oxidative Stress; Oxygen; Parkinson Disease; Plant Growth Regulators; Superoxides | 2021 |
Protective Effect of γ-mangostin Isolated from the Peel of
Topics: Acetylcysteine; Animals; Apoptosis; Calcium; Cell Death; Free Radical Scavengers; Garcinia mangostana; Glutamic Acid; Heme Oxygenase-1; Hippocampus; MAP Kinase Kinase 4; Membrane Proteins; Mice; Neurons; Neuroprotective Agents; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Xanthones | 2021 |
N-acetylcysteine, xCT and suppression of Maxi-chloride channel activity in human placenta.
Topics: Acetylcysteine; Amino Acid Transport System y+; Animals; Chloride Channels; Chorionic Villi; Female; Gene Expression; Glutamic Acid; HEK293 Cells; Humans; Oxidation-Reduction; Oxidative Stress; Placenta; Pregnancy; Proteome; Xenopus laevis | 2021 |
Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.
Topics: Acetylcysteine; Animals; Astrocytes; Biological Transport; Diet; Endocannabinoids; GABAergic Neurons; Glutamic Acid; Homeostasis; Hypertrophy; Male; Neural Inhibition; Neuronal Plasticity; Obesity; Prefrontal Cortex; Rats, Long-Evans; Synapses; Synaptic Transmission | 2021 |
Upregulation of Striatal Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Rats with Excessive Glutamate Release Induced by N-Acetylcysteine.
Topics: Acetylcysteine; Animals; Glutamic Acid; Rats; Receptors, Metabotropic Glutamate; Up-Regulation | 2022 |
Parthanatos participates in glutamate-mediated HT22 cell injury and hippocampal neuronal death in kainic acid-induced status epilepticus rats.
Topics: Acetylcysteine; Animals; Cell Death; Glutamic Acid; Hippocampus; Kainic Acid; Parthanatos; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Status Epilepticus | 2022 |
N-acetylcysteine in the treatment of compulsive sexual behavior disorder: A case series.
Topics: Acetylcysteine; Compulsive Behavior; Glutamic Acid; Humans; Male; Sexual Behavior; Sexual Dysfunctions, Psychological | 2022 |
Food for thought: diet-induced impairments to decision-making and amelioration by N-acetylcysteine in male rats.
Topics: Acetylcysteine; Animals; Corpus Striatum; Diet; Glutamic Acid; Learning; Male; Rats | 2022 |
Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathology and dys-regulations of Dopamine and Glutamate in rat brain.
Topics: Acetylcysteine; Animals; Brain; Diethylhexyl Phthalate; Dopamine; Gene Expression Regulation; Glutamic Acid; Male; Rats; Rats, Wistar; Zinc | 2023 |