acetylcysteine has been researched along with geldanamycin in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chavany, C; Mimnaugh, EG; Neckers, L | 1 |
| An, WG; Blagosklonny, MV; Neckers, L; Schulte, T; Sutphin, P; Whitesell, L | 1 |
| Grant, S; Vrana, JA | 1 |
| Haggie, PM; Stanton, BA; Verkman, AS | 1 |
| Caplan, AJ; Cardozo, CP; Fliss, AE; Hall, SJ; Michaud, C; Ost, MC; Patterson, C; Yang, E | 1 |
| Chang, WM; Huang, KL; Lai, MT; Lai, YK | 1 |
| Doong, H; Fang, S; Kohn, EC; Kulpa, V; Rizzo, K; Weissman, AM | 1 |
| Grandal, M; Hommelgaard, AM; Lerdrup, M; van Deurs, B | 1 |
| Freeman, ML; Fukuyo, Y; Higashikubo, R; Horikoshi, N; Horikoshi, NT; Hunt, C; Inoue, M; Nakajima, T; Usheva, A | 1 |
| Hou, JC; Pessin, JE; Vicogne, J; Williams, D | 1 |
| Dolezel, P; Mlejnek, P | 1 |
12 other study(ies) available for acetylcysteine and geldanamycin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin.
Topics: Acetylcysteine; Benzoquinones; Biopolymers; Breast Neoplasms; Cell Line; Cysteine Endopeptidases; Enzyme Inhibitors; Female; Humans; Lactams, Macrocyclic; Molecular Weight; Multienzyme Complexes; Polyubiquitin; Proteasome Endopeptidase Complex; Quinones; Receptor, ErbB-2; Rifabutin; Ubiquitins | 1996 |
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Topics: Acetylcysteine; Animals; Benzoquinones; Cycloheximide; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Enzyme Inhibitors; Half-Life; Humans; Lactams, Macrocyclic; Leupeptins; Mice; Multienzyme Complexes; Mutation; Octoxynol; Polyethylene Glycols; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Quinones; Rats; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ubiquitins | 1997 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Benzoquinones; Brefeldin A; Cell Line; Cell Membrane; CHO Cells; COS Cells; Cricetinae; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Diffusion; DNA, Complementary; Endoplasmic Reticulum; Enzyme Inhibitors; Green Fluorescent Proteins; Lactams, Macrocyclic; Light; Luminescent Proteins; Microscopy, Fluorescence; Molecular Chaperones; Mutagenesis, Site-Directed; Mutation; Protein Synthesis Inhibitors; Quinones; Recombinant Fusion Proteins; Time Factors; Transfection; Tunicamycin | 2002 |
C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.
Topics: Acetylcysteine; Benzoquinones; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Gene Expression; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Leupeptins; Ligases; Male; Molecular Chaperones; Multienzyme Complexes; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Quinones; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Tumor Cells, Cultured; Ubiquitin; Ubiquitin-Protein Ligases | 2003 |
Geldanamycin induction of grp78 requires activation of reactive oxygen species via ER stress responsive elements in 9L rat brain tumour cells.
Topics: Acetylcysteine; Animals; Antibiotics, Antineoplastic; Antioxidants; Base Sequence; Benzoquinones; Brain Neoplasms; Carrier Proteins; Endoplasmic Reticulum; Heat-Shock Proteins; Kinetics; Lactams, Macrocyclic; Molecular Chaperones; Molecular Sequence Data; Oxidative Stress; Promoter Regions, Genetic; Pyrrolidines; Quinones; Rats; Reactive Oxygen Species; Response Elements; RNA, Messenger; Thiocarbamates; Transcriptional Activation; Tumor Cells, Cultured | 2003 |
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Apoptosis; Apoptosis Regulatory Proteins; Benzoquinones; Breast Neoplasms; Carrier Proteins; Cysteine Endopeptidases; Enzyme Inhibitors; Gene Deletion; Gene Expression; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Immunosorbent Techniques; Lactams, Macrocyclic; Multienzyme Complexes; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinones; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Topics: Acetylcysteine; Animals; Benzoquinones; Biological Assay; Cell Line, Tumor; Cell Membrane; Cysteine Proteinase Inhibitors; Endocytosis; Fluorescence Recovery After Photobleaching; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lysosomes; Microscopy, Confocal; Proteasome Endopeptidase Complex; Protein Structure, Tertiary; Receptor, ErbB-2 | 2006 |
Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Benzoquinones; Cell Line, Tumor; Enzyme Activation; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Mutation; Oxidative Stress; Proto-Oncogene Proteins B-raf | 2008 |
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.
Topics: 3T3-L1 Cells; Acetylcysteine; Animals; Benzoquinones; Cell Membrane; Chloroquine; Endocytosis; Exocytosis; Glucose Transporter Type 1; Glucose Transporter Type 2; Glucose Transporter Type 4; Lactams, Macrocyclic; Lysosomes; Mice | 2009 |
N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin-N-acetylcysteine adduct.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Apoptosis; Benzoquinones; Cell Cycle; Glutathione; Humans; K562 Cells; Lactams, Macrocyclic; Molecular Structure | 2014 |