acetylcysteine and erythromycin

acetylcysteine has been researched along with erythromycin in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (14.29)	18.7374
1990's	5 (8.93)	18.2507
2000's	13 (23.21)	29.6817
2010's	28 (50.00)	24.3611
2020's	2 (3.57)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chen, F; Chen, W; Lan, L; Li, B; Li, J; Liu, Y; Mao, F; Ni, S; Wei, H; Zhu, J	1
Pomarelli, P	1
Navashin, SM; Nikitin, AV	1
Fregnan, GB; Gazzani, G; Mazzone, A; Pasotti, D; Ricevuti, G	1
De Bernardi, M; Feletti, F; Fregnan, GB; Gazzani, G	1
Borgström, L; Kågedal, B; Paulsen, O; Walder, M	1
Brown, RD; Henley, CM; Kupetz, S; Penny, JE	1
Lawson, D; Saggers, BA	2
Fuqua, WB; Giffin, RB; Harrison, HS	1
Benet, LZ; Berg-Candolfi, M; Candolfi, E	1
Ichian, H; Muranaka, H; Nishimura, J; Okamoto, T; Sato, K; Sugamori, T; Takahashi, T; Tomoshima, Y	1
Albini, E; Belluco, G; Berton, M; Schioppacassi, G; Ungheri, D	1
Albini, E; Arena, E; Belluco, G; Schioppacassi, G; Ungheri, D	1
Ahl, M; Bush, A; Huang, X; Rogers, JT; Tucker, S; Westaway, D	1
Yarwood, SJ	1
Curci, S; Gerbino, A; Hofer, AM; Pozzan, T; Ruder, WC; Zaccolo, M	1
Cohen, G; Kodama, T; Makranz, C; Reichert, F; Rotshenker, S	1
Conley, RR; Dwivedi, Y; Faludi, G; Mondal, AC; Palkovits, M; Pandey, GN; Rizavi, HS; Sarosi, A	1
Ahl, M; Bandyopadhyay, S; Bush, AI; Cho, HH; Cuny, GD; Goldstein, LE; Huang, X; Rogers, JT; Tucker, S; Westaway, D	1
Badran, B; El Zein, N; Sariban, E	1
Im, MJ; Kim, BJ; Kim, UH; Okamoto, H; Park, KH; Takasawa, S; Yim, CY	1
Abel, T; Bizily, SF; Esposito, MF; Favilla, C; Kanes, SJ; Kelly, MP; Stein, JM; Vecsey, CG; Wand, G; Yang, X	1
Dart, C; Davies, LM; Kamishima, T; Purves, GI; Quayle, JM	1
Eggo, MC	1
del Carmen Ponte, M; del Prado, G; Naves, P; Rodríguez-Cerrato, V; Ruiz, V; Soriano, F	1
Bond, M; Hewer, RC; Newby, AC; Sala-Newby, GB; Wu, YJ	1
Lim, Q'; Too, HP; Wan, G; Wong, YH; Zhou, L	1
Bengtsson, T; Dehvari, N; Öberg, AI	1
Boittin, FX; Dorchies, OM; Patthey-Vuadens, O; Reutenauer-Patte, J; Ruegg, UT	1
Nikiteas, N; Perrea, D; Tsigris, C; Yiannakopoulou, E	1
Gratzke, C; Hennenberg, M; Rutz, B; Schmetkamp, H; Stief, CG; Strittmatter, F; Walther, S	1
Barnett, SC; Boomkamp, SD; Houslay, MD; McGrath, MA	1
Dezaki, K; Ishikawa, SE; Ito, K; Kakei, M; Kawakami, M; Kodera, S; Lam, NV; Rita, RS; Shimomura, K; Sugawara, H; Tominaga, M; Uchida, K; Yada, T; Yamada, H; Yosida, M	1
Bailey, KL; DeVasure, JM; Heires, AJ; Nordgren, TM; Poole, JA; Romberger, DJ; Wyatt, TA	1
Brandt, S; Dent, A; Medeiros, A; Serezani, CH; Wang, S; Wang, Z; Wu, H	1
Boulton, S; Chen, H; Cheng, X; Mei, F; Melacini, G; Ye, N; Zhou, J; Zhu, Y	1
Duan, XP; Fan, LL; Zhang, DD	1
Fukada, S; Hoshino, M; Ikawa, M; Mikami, N; Miyagoe-Suzuki, Y; Nakamura, M; Ohtani, T; Sato, T; Takeda, S; Tsuchida, K; Tsujikawa, K; Uezumi, A; Watanabe, Y; Yamaguchi, M; Yamamoto, H	1
Henquin, JC; Nenquin, M	1
Cordero-Ampuero, J; Del-Prado, G; Esteban, J; Fernandez-Roblas, R; Gómez-Barrena, E; Molina-Manso, D	1
Antonetti, DA; Ramos, CJ	1
Antonetti, DA; Lin, C; Liu, X; Ramos, CJ	1
Ghavami, R; Kompany-Zareh, M; Omidikia, N; Sepehri, B	1
Cheng, X; Robichaux, WG	1
Hu, ZQ; Li, YJ; Li, ZG; Song, SD; Tang, HF; Wang, XF; Yan, CG; Zhang, ZW	1
Gu, Y; Huang, LM; Li, G	1
Hosoi, M; Kato, TA; Sasaki, I; Tozaki-Saitoh, H; Tsuda, M; Yamashita, T	1
Hoy, JJ; Iglesias-Bartolome, R; Kuhn, S; Park, J; Salinas Parra, N	1

Reviews

7 review(s) available for acetylcysteine and erythromycin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Link between functional and morphological changes in the inner ear--functional changes produced by ototoxic agents and their interactions. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1985, Volume: 8 Topics: Acetylcysteine; Adult; Aminoglycosides; Aminooxyacetic Acid; Anesthetics; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Aspirin; Child; Chloramphenicol; Cochlea; Cochlear Microphonic Potentials; Diuretics; Drug Synergism; Erythromycin; Evoked Potentials, Auditory; Glycerol; Guinea Pigs; Hair Cells, Auditory; Hearing Loss, Sensorineural; Humans; Labyrinth Diseases; Noise; Otitis Media; Rats; Stria Vascularis	1985
Microtubule-associated proteins (MAPs) regulate cAMP signalling through exchange protein directly activated by cAMP (EPAC). Biochemical Society transactions, 2005, Volume: 33, Issue:Pt 6 Topics: Acetylcysteine; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Microtubule-Associated Proteins; Protein Binding; rap1 GTP-Binding Proteins; Second Messenger Systems	2005
Molecular regulation of thyroid gland function. Current opinion in endocrinology, diabetes, and obesity, 2010, Volume: 17, Issue:5 Topics: Acetylcysteine; Animals; Erythromycin; Humans; Insulin; Insulin-Like Growth Factor I; Integrins; Iodides; Mice; Mitogen-Activated Protein Kinases; Peptide Hydrolases; Phosphatidylinositol 3-Kinase; Plasminogen Activators; Rats; Signal Transduction; Thyroid Gland; Thyroid Neoplasms; Vascular Endothelial Growth Factor A	2010
Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review. Surgical laparoscopy, endoscopy & percutaneous techniques, 2012, Volume: 22, Issue:3 Topics: Acetylcysteine; Animals; Antioxidants; Biomarkers; Erythromycin; Humans; Laparoscopy; Melatonin; Mesna; Oxidative Stress; Pentoxifylline; Pneumoperitoneum, Artificial; Rabbits; Rats; Verapamil; Zinc Compounds	2012
The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers. Tissue barriers, 2017, 07-03, Volume: 5, Issue:3 Topics: Acetylcysteine; Animals; Blood-Brain Barrier; Blood-Retinal Barrier; Erythromycin; Humans; Monomeric GTP-Binding Proteins; Signal Transduction	2017
Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. Physiological reviews, 2018, 04-01, Volume: 98, Issue:2 Topics: Acetylcysteine; Animals; Cytoplasm; Erythromycin; Guanine Nucleotide Exchange Factors; Humans; Protein Transport; Receptors, Cyclic AMP; Signal Transduction	2018

Trials

2 trial(s) available for acetylcysteine and erythromycin

Article	Year
Serum, sputum and bronchial concentrations of erythromycin in chronic bronchitis after single and multiple treatments with either propionate-N-acetylcysteinate or stearate erythromycin. Chemotherapy, 1988, Volume: 34, Issue:5 Topics: Acetylcysteine; Administration, Oral; Bronchi; Bronchitis; Chronic Disease; Double-Blind Method; Erythromycin; Female; Humans; Intestinal Absorption; Male; Middle Aged; Mucus; Sputum	1988
Human pharmacokinetics of erythromycin propionate-N-acetylcysteinate: comparative evaluation with erythromycin stearate and N-acetylcysteine. International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:9 Topics: Acetylcysteine; Adult; Biological Availability; Erythromycin; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged	1988

Article

Year

Serum, sputum and bronchial concentrations of erythromycin in chronic bronchitis after single and multiple treatments with either propionate-N-acetylcysteinate or stearate erythromycin.

Chemotherapy, 1988, Volume: 34, Issue:5

Topics: Acetylcysteine; Administration, Oral; Bronchi; Bronchitis; Chronic Disease; Double-Blind Method; Erythromycin; Female; Humans; Intestinal Absorption; Male; Middle Aged; Mucus; Sputum

1988

Human pharmacokinetics of erythromycin propionate-N-acetylcysteinate: comparative evaluation with erythromycin stearate and N-acetylcysteine.

International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:9

Topics: Acetylcysteine; Adult; Biological Availability; Erythromycin; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged

1988

Other Studies

47 other study(ies) available for acetylcysteine and erythromycin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. Journal of medicinal chemistry, 2018, 01-11, Volume: 61, Issue:1 Topics: Animals; Drug Design; Enzyme Inhibitors; ERG1 Potassium Channel; HEK293 Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; Methicillin-Resistant Staphylococcus aureus; Mice; Oxidoreductases; Rats; Safety; Solubility; Structure-Activity Relationship; Water	2018
[Pharmacological study of an antibiotic-mucolytic combination]. Il Farmaco; edizione pratica, 1978, Volume: 33, Issue:9 Topics: Acetylcysteine; Amino Acids, Sulfur; Animals; Bacteria; Bronchi; Cats; Dogs; Drug Combinations; Erythromycin; Expectorants; Female; Fetus; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Mice; Rabbits; Rats; Respiration; Tiopronin	1978
[New macrolide antibiotics, rifamycins and peptide antibiotics discussed at the 27th International Conference on Antimicrobial Agents and Chemotherapy]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1991, Volume: 36, Issue:2 Topics: Acetylcysteine; Anti-Bacterial Agents; Azithromycin; Bacterial Infections; Congresses as Topic; Daptomycin; Disaccharides; Drug Evaluation; Erythromycin; Glycopeptides; Humans; New York City; Peptides; Rifamycins	1991
No effect of oral N-acetylcysteine on the bioavailability of erythromycin and bacampicillin. The European respiratory journal, 1988, Volume: 1, Issue:2 Topics: Acetylcysteine; Administration, Oral; Adult; Ampicillin; Biological Availability; Erythromycin; Female; Humans; Male; Middle Aged	1988
In vivo penetration of antibiotics into sputum in cystic fibrosis. Archives of disease in childhood, 1968, Volume: 43, Issue:230 Topics: Acetylcysteine; Aerosols; Ampicillin; Anti-Bacterial Agents; Biological Assay; Cephaloridine; Cloxacillin; Cystic Fibrosis; Erythromycin; Gentamicins; Humans; Infection Control; Lincomycin; Methicillin; Molecular Weight; Novobiocin; Sputum; Sulfonamides	1968
Congenital laryngeal cleft: report of a case. A comparison with other types of tracheo-esophageal communication. American journal of diseases of children (1960), 1965, Volume: 110, Issue:5 Topics: Acetylcysteine; Chloramphenicol; Diagnosis, Differential; Erythromycin; Female; Humans; Infant, Newborn; Laryngoscopy; Larynx; Penicillins; Pneumonia; Streptomycin; Tracheoesophageal Fistula; Tracheotomy	1965
Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:4 Topics: Acetylcysteine; Animals; Antibodies, Monoclonal; Arginine; Aryl Hydrocarbon Hydroxylases; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Interferon-gamma; Intestinal Mucosa; Jejunum; Macrophages, Peritoneal; Male; Mice; Mice, Inbred CBA; Microsomes; Microsomes, Liver; Nitrites; Oxidoreductases, N-Demethylating; Toxoplasmosis, Animal	1996
[Effects of erythromycin on Pseudomonas aeruginosa pyocyanine-induced IL-8 production and its biological activity (the 2nd report)]. The Japanese journal of antibiotics, 1998, Volume: 51 Suppl A Topics: Acetylcysteine; Anti-Bacterial Agents; Cells, Cultured; Dimethyl Sulfoxide; Erythromycin; Humans; Interleukin-8; Macrophages, Alveolar; Pseudomonas aeruginosa; Pyocyanine; Superoxide Dismutase	1998
In vitro antibacterial activity of thiamphenicol glycinate acetylcysteinate against respiratory pathogens. Arzneimittel-Forschung, 1999, Volume: 49, Issue:6 Topics: Acetylcysteine; Amoxicillin; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Drug Combinations; Erythromycin; Microbial Sensitivity Tests; Penicillins; Respiratory Tract Infections; Thiamphenicol	1999
Activity of aerosol thiamphenicol glycinate acetylcysteinate in a mouse model of S. pyogenes pneumonia. Arzneimittel-Forschung, 1999, Volume: 49, Issue:7 Topics: Acetylcysteine; Aerosols; Amoxicillin; Animals; Anti-Bacterial Agents; Drug Combinations; Erythromycin; Female; Lung; Mice; Microbial Sensitivity Tests; Penicillins; Pneumonia, Bacterial; Streptococcal Infections; Streptococcus pyogenes; Thiamphenicol	1999
N.A.C. AND ANTIBIOTICS IN CYSTIC FIBROSIS. British medical journal, 1965, Jan-30, Volume: 1, Issue:5430 Topics: Acetylcysteine; Ampicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Cysteine; Cystic Fibrosis; Erythromycin; Fusidic Acid; Humans; Penicillins; Pharmacology; Protein Synthesis Inhibitors; Tetracycline	1965
Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region. Current Alzheimer research, 2005, Volume: 2, Issue:2 Topics: 5' Untranslated Regions; Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Drug Approval; Drugs, Investigational; Erythromycin; Mice; Mice, Transgenic; Paroxetine; Pilot Projects	2005
Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations. The Journal of cell biology, 2005, Oct-24, Volume: 171, Issue:2 Topics: Acetylcysteine; Biosensing Techniques; Calcium; Calcium Signaling; Cell Line; Cell Membrane; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Fluorescence Resonance Energy Transfer; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Pertussis Toxin; Receptors, Calcium-Sensing; Sensitivity and Specificity; Signal Transduction	2005
cAMP cascade (PKA, Epac, adenylyl cyclase, Gi, and phosphodiesterases) regulates myelin phagocytosis mediated by complement receptor-3 and scavenger receptor-AI/II in microglia and macrophages. Glia, 2006, Volume: 53, Issue:4 Topics: Acetylcysteine; Adenylyl Cyclases; Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme-Linked Immunosorbent Assay; Erythromycin; GTP-Binding Protein alpha Subunits, Gi-Go; Indicators and Reagents; Macrophage-1 Antigen; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microglia; Myelin Sheath; Phagocytosis; Phosphoric Diester Hydrolases; Scavenger Receptors, Class A; Signal Transduction	2006
Differential and brain region-specific regulation of Rap-1 and Epac in depressed suicide victims. Archives of general psychiatry, 2006, Volume: 63, Issue:6 Topics: Acetylcysteine; Adult; Aged; Brain; Brain Chemistry; Cerebellum; Depressive Disorder; Erythromycin; Female; Gene Expression Regulation; Hippocampus; Humans; Male; Middle Aged; Neuronal Plasticity; Prefrontal Cortex; rap1 GTP-Binding Proteins; RNA, Messenger; Suicide; Tissue Distribution	2006
RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Current Alzheimer research, 2006, Volume: 3, Issue:3 Topics: 5' Untranslated Regions; Acetylcysteine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Drug Evaluation, Preclinical; Drugs, Investigational; Erythromycin; Mice; Mice, Transgenic; Paroxetine; Peptide Fragments; Pilot Projects; Protein Biosynthesis; Protein Synthesis Inhibitors; RNA, Messenger	2006
VIP differentially activates beta2 integrins, CR1, and matrix metalloproteinase-9 in human monocytes through cAMP/PKA, EPAC, and PI-3K signaling pathways via VIP receptor type 1 and FPRL1. Journal of leukocyte biology, 2008, Volume: 83, Issue:4 Topics: Acetylcysteine; Animals; Calcium; CD18 Antigens; Cell Line; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Humans; Matrix Metalloproteinase 9; Monocytes; Neutrophils; Polymerase Chain Reaction; Receptors, Complement 3b; Receptors, Formyl Peptide; Receptors, Lipoxin; Receptors, Vasoactive Intestinal Polypeptide, Type I; Signal Transduction; Transfection; Vasoactive Intestinal Peptide	2008
Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets. Diabetes, 2008, Volume: 57, Issue:4 Topics: Acetylcysteine; ADP-ribosyl Cyclase 1; Animals; Calcium; Cyclic ADP-Ribose; Endoplasmic Reticulum; Erythromycin; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred ICR; Mice, Knockout; NADP; Signal Transduction	2008
Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. Molecular psychiatry, 2009, Volume: 14, Issue:4 Topics: Acetylcysteine; Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Brain; Cognition Disorders; Conditioning, Psychological; Cyclic AMP; Disease Models, Animal; Erythromycin; Exploratory Behavior; Fear; Female; Gene Expression Regulation, Developmental; GTP-Binding Protein alpha Subunits, Gs; Haloperidol; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphodiesterase Inhibitors; Psychophysics; Reflex, Startle; Rolipram; Time Factors	2009
Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. The Journal of physiology, 2009, Jul-15, Volume: 587, Issue:Pt 14 Topics: Acetylcysteine; Animals; Aorta; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Ion Channel Gating; KATP Channels; Male; Membrane Potentials; Muscle, Smooth, Vascular; Myocytes, Cardiac; Rats; Rats, Wistar	2009
Biofilm formation by Streptococcus pneumoniae strains and effects of human serum albumin, ibuprofen, N-acetyl-l-cysteine, amoxicillin, erythromycin, and levofloxacin. Diagnostic microbiology and infectious disease, 2010, Volume: 67, Issue:4 Topics: Acetylcysteine; Amoxicillin; Anti-Bacterial Agents; Biofilms; Erythromycin; Humans; Ibuprofen; Levofloxacin; Ofloxacin; Serum Albumin; Streptococcus pneumoniae	2010
PKA and Epac synergistically inhibit smooth muscle cell proliferation. Journal of molecular and cellular cardiology, 2011, Volume: 50, Issue:1 Topics: Acetylcysteine; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Paxillin; Phalloidine; rap1 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering	2011
Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRα2 isoforms. Cellular signalling, 2011, Volume: 23, Issue:11 Topics: Acetylcysteine; Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Nerve Regeneration; Neurites; Neurturin; Phosphorylation; Protein Isoforms; Proto-Oncogene Proteins c-ret; Rats; Real-Time Polymerase Chain Reaction; Signal Transduction; Transfection	2011
β-Adrenergic inhibition of contractility in L6 skeletal muscle cells. PloS one, 2011, Volume: 6, Issue:7 Topics: Acetylcysteine; Adrenergic beta-Agonists; Animals; Calcium; Cell Adhesion; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Erythromycin; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium Channels; Protein Kinase C; Rats; Receptors, Adrenergic, beta-2; rho-Associated Kinases; Signal Transduction	2011
Urocortins improve dystrophic skeletal muscle structure and function through both PKA- and Epac-dependent pathways. The American journal of pathology, 2012, Volume: 180, Issue:2 Topics: Acetylcysteine; Animals; Brefeldin A; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Group VI Phospholipases A2; Injections, Intradermal; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Animal; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Receptors, Corticotropin-Releasing Hormone; Stromal Interaction Molecule 1; Urocortins	2012
The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction. Journal of biomedical science, 2013, Jul-02, Volume: 20 Topics: Acetylcysteine; Erythromycin; ets-Domain Protein Elk-1; Humans; Immunohistochemistry; Male; Muscle Contraction; Muscle, Smooth; Prostate; Receptors, Adrenergic, alpha-1; Signal Transduction; Urinary Tract	2013
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. British journal of pharmacology, 2014, Volume: 171, Issue:9 Topics: Acetylcysteine; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Erythromycin; Nerve Fibers, Myelinated; Neurites; Phosphodiesterase 4 Inhibitors; Protein Binding; Rats; Rats, Sprague-Dawley; Rolipram; Spinal Cord Injuries	2014
Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion. Diabetes, 2014, Volume: 63, Issue:10 Topics: Acetylcysteine; Animals; Calcium; Cyclic AMP; Erythromycin; Exenatide; Glucose; Incretins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Knockout; Peptides; Rats, Wistar; Signal Transduction; TRPM Cation Channels; Venoms	2014
cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells. American journal of physiology. Lung cellular and molecular physiology, 2014, Oct-15, Volume: 307, Issue:8 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcysteine; ADAM Proteins; ADAM17 Protein; Animal Feed; Animals; Bronchi; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dust; Enzyme-Linked Immunosorbent Assay; Erythromycin; Humans; Interleukin-6; Interleukin-8; Mice; Mice, Inbred C57BL; Protein Kinase C-epsilon; Swine; Tumor Necrosis Factor-alpha	2014
MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation. PloS one, 2015, Volume: 10, Issue:2 Topics: Acetylcysteine; Animals; Cell Polarity; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Erythromycin; Female; Gene Silencing; Homeostasis; Macrophage Activation; Macrophages; Mice; Mice, Knockout; MicroRNAs; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins	2015
Biochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window". Scientific reports, 2015, Mar-20, Volume: 5 Topics: Acetylcysteine; Animals; Erythromycin; Hydrazones; Isoxazoles; Mice; Mice, Knockout; Structure-Activity Relationship	2015
[The role of Epac in kidney tuble physiology]. Sheng li ke xue jin zhan [Progress in physiology], 2015, Volume: 46, Issue:2 Topics: Acetylcysteine; Erythromycin; Kidney Tubules	2015
Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche. Cell reports, 2015, Oct-13, Volume: 13, Issue:2 Topics: Acetylcysteine; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Mice; Myoblasts; Receptors, Calcitonin; Second Messenger Systems; Stem Cell Niche	2015
Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells. Diabetes, obesity & metabolism, 2016, Volume: 18, Issue:7 Topics: Acetylcysteine; Animals; Bucladesine; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice, Inbred C57BL; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide	2016
Effect of different agents with potential antibiofilm activity on antimicrobial susceptibility of biofilms formed by Staphylococcus spp. isolated from implant-related infections. The Journal of antibiotics, 2016, Volume: 69, Issue:9 Topics: Acetylcysteine; Anti-Bacterial Agents; Biofilms; Erythromycin; Humans; Microbial Sensitivity Tests; Prosthesis-Related Infections; Species Specificity; Staphylococcus aureus; Staphylococcus epidermidis	2016
The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. The Journal of biological chemistry, 2018, 01-12, Volume: 293, Issue:2 Topics: Acetylcysteine; Animals; Capillary Permeability; Cytokines; Erythromycin; Humans; rap1 GTP-Binding Proteins; Receptors, Vascular Endothelial Growth Factor; Retina; Signal Transduction	2018
Predictive and Descriptive CoMFA Models: The Effect of Variable Selection. Combinatorial chemistry & high throughput screening, 2018, Volume: 21, Issue:2 Topics: Acetylcysteine; ADP-ribosyl Cyclase 1; Algorithms; ATPases Associated with Diverse Cellular Activities; Datasets as Topic; DNA-Binding Proteins; Erythromycin; Models, Chemical; Quantitative Structure-Activity Relationship	2018
Protective Effect of Quercetin in LPS-Induced Murine Acute Lung Injury Mediated by cAMP-Epac Pathway. Inflammation, 2018, Volume: 41, Issue:3 Topics: Acetylcysteine; Acute Lung Injury; Animals; Cell Line; Cyclic AMP; Erythromycin; Inflammation; Inflammation Mediators; Lipopolysaccharides; Lung; Mice; Protective Agents; Quercetin	2018
Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia. Pain, 2018, Volume: 159, Issue:11 Topics: Acetylcysteine; Action Potentials; Animals; Biotinylation; Capsaicin; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Erythromycin; Freund's Adjuvant; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Neurons; Patch-Clamp Techniques; Protein Kinase C-alpha; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X4; Signal Transduction; TRPV Cation Channels	2018
Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors. Journal of pharmacological sciences, 2020, Volume: 143, Issue:3 Topics: Acetylcysteine; Adrenergic beta-Agonists; Animals; Cells, Cultured; Erythromycin; Gene Expression; Interleukin-1beta; Isoproterenol; MAP Kinase Kinase Kinases; Mice; Microglia; Norepinephrine; Proto-Oncogene Proteins; Receptors, Adrenergic, beta; Signal Transduction; Up-Regulation	2020
Protein kinase A inhibitor proteins (PKIs) divert GPCR-Gαs-cAMP signaling toward EPAC and ERK activation and are involved in tumor growth. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:10 Topics: Acetylcysteine; Animals; Cell Line, Tumor; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Extracellular Signal-Regulated MAP Kinases; Feedback, Physiological; Female; GTP-Binding Protein alpha Subunits; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; MAP Kinase Signaling System; Mice; Mice, Nude; Prostatic Neoplasms	2020