acetylcysteine and epoxomicin

acetylcysteine has been researched along with epoxomicin in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's24 (66.67)29.6817
2010's10 (27.78)24.3611
2020's2 (5.56)2.80

Authors

AuthorsStudies
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Crews, CM; de Giuli, R; Groettrup, M; Kim, KB; Kostka, S; Kraft, R; Schmidtke, G; Schwarz, K; van den Broek, M1
Chau, V; Patnaik, A; Wills, JW1
Altun, M; Fiebiger, E; Hekking, BG; Kessler, BM; Kisselev, AF; Overkleeft, HS; Ploegh, HL; Tortorella, D1
Burrows, J; Hale, PD; Hidvegi, T; Perlmutter, DH; Schmidt, B; Teckman, JH1
Bogyo, M; Wang, EW1
Kikuchi, S; Niino, M; Shinpo, K; Takeuchi, M; Tashiro, K; Tsuji, S; Yabe, I1
Bescos, PB; Davies, KJ; Grune, T; Li, R; North, JA; Reinheckel, T; Shringarpure, R1
Lindquist, S; Ma, J1
Dean, RT; Rodgers, KJ1
Dryden, SC; Goustin, AS; Nahhas, FA; Nowak, JE; Tainsky, MA1
Bland, FA; Braud, VM; Lemberg, MK; Martoglio, B; McMichael, AJ1
Alessandri, MG; Busceti, CL; Ferrucci, M; Fornai, F; Gesi, M; Lazzeri, G; Lenzi, P; Paparelli, A; Ruffoli, R; Ruggieri, S; Soldani, P1
Jaarsma, D; Vlug, AS1
Liang, JN; Marques, C; Pereira, P; Reddy, VN; Shang, F; Szweda, LI; Taylor, A1
Levine, L1
Ando, K; Hayakawa, M; Kikugawa, K; Kiuchi, Y; Shimizu, K1
Ballestrero, A; Barbieri, E; Belka, C; Brossart, P; Cardone, MH; Dillon, CP; Garuti, A; Hua, F; Nencioni, A; Patrone, F; Rocco, I; Scheiermann, C; Wesselborg, S; Yokoo, R1
Lang-Rollin, IC; Rideout, HJ; Savalle, M; Stefanis, L1
Block, T; Dwek, RA; Mehta, A; Simsek, E; Zhou, T1
Berges, C; Daniel, V; Fuchs, D; Höh, A; Miltz, M; Naujokat, C; Opelz, G; Ovens, J; Sadeghi, M; Wieczorek, H1
Anselmino, A; Atzori, C; Cargnel, A; Mazza, F; Piccinini, M; Rinaudo, MT; Tronconi, E; Valerio, A1
Pollenz, RS1
Ballard, C; Iravani, MM; Jenner, P; MacInnes, N; Perry, E; Perry, R; Piggott, M1
Gonzalez-Alegre, P; Gordon, KL1
Alden, CL; Cardoza, K; Csizmadia, E; Csizmadia, V; Fedyk, ER; Gallacher, M; Kadambi, VJ; O'Brien, L; Raczynski, A; Silverman, L; Simpson, C1
Castellanos, E; Gómez, V; Martínez, JD; Paciucci, R; Santamaría, A; Sesé, M; Soler, M; Thomson, TM1
Bui, TN; Efuet, ET; Keyomarsi, K1
Alvarez-Velilla, R; Balaña-Fouce, R; Estrada, CG; Pérez-Pertejo, Y; Reguera, RM1
Bajic, N; Ballard, CG; Francis, PT; Jenner, P1
Ha, YH; Kim, YE; Kwon, HJ; Lee, Y; Park, JA1
Berger, H; Hain, T; Schild, H; Tenzer, S1
Baltrusch, S; Hofmeister-Brix, A; Lenzen, S1
Cohen, LD; Hakim, V; Ziv, NE; Ziv, T; Zuchman, R1
Chatterjee Bhowmick, D; Jeremic, A1
Lee, BH; Nicola, AV; Schneider, SM1

Reviews

2 review(s) available for acetylcysteine and epoxomicin

ArticleYear
Proteasome inhibitors: complex tools for a complex enzyme.
    Current topics in microbiology and immunology, 2002, Volume: 268

    Topics: Acetylcysteine; Affinity Labels; Animals; Catalysis; Cysteine Endopeptidases; Drug Design; Humans; Molecular Structure; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Structure-Activity Relationship; Substrate Specificity

2002
Viral entry and the ubiquitin-proteasome system.
    Cellular microbiology, 2021, Volume: 23, Issue:2

    Topics: Acetylcysteine; Animals; Antiviral Agents; Bortezomib; Host Microbial Interactions; Humans; Leupeptins; Nucleocapsid; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ubiquitin; Virion; Virus Internalization; Virus Physiological Phenomena; Viruses

2021

Other Studies

34 other study(ies) available for acetylcysteine and epoxomicin

ArticleYear
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Jun-15, Volume: 164, Issue:12

    Topics: Acetylcysteine; Amino Acid Sequence; Animals; Antigen Presentation; Antigens, Viral; Apoptosis; Cell Division; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Immunologic; Down-Regulation; Glycoproteins; Humans; Hybridomas; Hydrolysis; Lymphocyte Activation; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Sequence Data; Multienzyme Complexes; Nucleoproteins; Oligopeptides; Peptide Fragments; Proteasome Endopeptidase Complex; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured; Ubiquitins; Up-Regulation; Viral Proteins

2000
Ubiquitin is part of the retrovirus budding machinery.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Nov-21, Volume: 97, Issue:24

    Topics: Acetylcysteine; Animals; Avian Sarcoma Viruses; Cell Line; Cell Membrane; Cysteine Endopeptidases; Endocytosis; Gene Products, gag; Leupeptins; Multienzyme Complexes; Oligopeptides; Protease Inhibitors; Proteasome Endopeptidase Complex; Quail; Recombinant Fusion Proteins; Ubiquitins; Virus Replication

2000
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
    Chemistry & biology, 2001, Volume: 8, Issue:9

    Topics: Acetylcysteine; Catalytic Domain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; HeLa Cells; Humans; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Peptides; Proteasome Endopeptidase Complex; Sulfones

2001
The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes.
    The Journal of biological chemistry, 2001, Nov-30, Volume: 276, Issue:48

    Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Antibiotics, Antineoplastic; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; HeLa Cells; Hepatocytes; Humans; Lactones; Leupeptins; Liver; Mice; Multienzyme Complexes; Mutation; Oligopeptides; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Binding; Rats; Time Factors; Transfection; Tumor Cells, Cultured

2001
Effect of geranylgeranylaceton on cellular damage induced by proteasome inhibition in cultured spinal neurons.
    Journal of neuroscience research, 2002, Aug-01, Volume: 69, Issue:3

    Topics: Acetylcysteine; Animals; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diterpenes; Dose-Response Relationship, Drug; Glutathione; HSP70 Heat-Shock Proteins; Immunoblotting; Immunohistochemistry; Mitochondria; Multienzyme Complexes; Neurons; Neuroprotective Agents; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Spinal Cord; Thioredoxins; Time Factors

2002
Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:12

    Topics: Acetylcysteine; Animals; Blood Proteins; Blotting, Western; Catalysis; Cell Line; Cell Size; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Hydrogen Peroxide; Liver; Membrane Proteins; Microfilament Proteins; Multienzyme Complexes; Oligopeptides; Oxidative Stress; Phosphoproteins; Proteasome Endopeptidase Complex; Proteins; Rats; Sulfones

2002
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
    Science (New York, N.Y.), 2002, Nov-29, Volume: 298, Issue:5599

    Topics: Acetylcysteine; Animals; COS Cells; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cystic Fibrosis Transmembrane Conductance Regulator; Cytosol; Endopeptidase K; Endoplasmic Reticulum; Leupeptins; Mice; Models, Biological; Multienzyme Complexes; Neurons; Oligopeptides; Prions; Proteasome Endopeptidase Complex; Protein Conformation; Protein Folding; Protein Transport; PrPSc Proteins; Solubility; Transfection; Tumor Cells, Cultured

2002
Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates.
    The international journal of biochemistry & cell biology, 2003, Volume: 35, Issue:5

    Topics: Acetylcysteine; Animals; Cell Line; Chromatography, Gel; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Mice; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Substrate Specificity; Ubiquitin

2003
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.
    Molecular and cellular biology, 2003, Volume: 23, Issue:9

    Topics: Acetylcysteine; Animals; Antibody Specificity; Cell Cycle; Cells, Cultured; Cysteine Proteinase Inhibitors; Cytoplasm; Dual-Specificity Phosphatases; Electrophoresis, Polyacrylamide Gel; Humans; Mitosis; Mutagenesis, Site-Directed; NAD; Oligopeptides; Peptide Hydrolases; Phosphoric Monoester Hydrolases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Tyrosine Phosphatases; Rabbits; Sirtuin 2; Sirtuins; Transfection; Ubiquitin

2003
Requirement of the proteasome for the trimming of signal peptide-derived epitopes presented by the nonclassical major histocompatibility complex class I molecule HLA-E.
    The Journal of biological chemistry, 2003, Sep-05, Volume: 278, Issue:36

    Topics: Acetylcysteine; Acids; Alleles; Amino Acid Sequence; Aspartic Acid Endopeptidases; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Epitopes; Flow Cytometry; Histocompatibility Antigens Class I; HLA Antigens; HLA-E Antigens; HLA-G Antigens; Humans; Ligands; Membrane Proteins; Molecular Sequence Data; Multienzyme Complexes; Oligopeptides; Peptide Hydrolases; Peptides; Plasmids; Proteasome Endopeptidase Complex; Protein Biosynthesis; Protein Structure, Tertiary; Serine Endopeptidases; Transcription, Genetic; Transfection

2003
Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Oct-01, Volume: 23, Issue:26

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Cell Death; Corpus Striatum; Cysteine Endopeptidases; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Inclusion Bodies; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Multienzyme Complexes; Nerve Tissue Proteins; Oligopeptides; PC12 Cells; Pheochromocytoma; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Signal Transduction; Substantia Nigra; Tyrosine 3-Monooxygenase

2003
Long term proteasome inhibition does not preferentially afflict motor neurons in organotypical spinal cord cultures.
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2004, Volume: 5, Issue:1

    Topics: Acetylcysteine; Activating Transcription Factor 3; Animals; Cell Count; Cell Survival; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Immunohistochemistry; Interneurons; Mice; Mice, Transgenic; Motor Neurons; Neurofilament Proteins; Oligopeptides; Organ Culture Techniques; Protease Inhibitors; Spinal Cord; Superoxide Dismutase; Time Factors; Transcription Factors; Ubiquitin

2004
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:12

    Topics: Acetylcysteine; Adenosine Triphosphate; Aldehydes; alpha-Crystallin B Chain; Cell-Free System; Cells, Cultured; Epithelial Cells; Humans; Lens, Crystalline; Leupeptins; Lysosomes; Oligopeptides; Oxidative Stress; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Ubiquitin

2004
Proteasome inhibitors: their effects on arachidonic acid release from cells in culture and arachidonic acid metabolism in rat liver cells.
    BMC pharmacology, 2004, Aug-05, Volume: 4

    Topics: Acetylcysteine; Animals; Arachidonic Acid; Breast Neoplasms; Cell Line; Cell Line, Tumor; HT29 Cells; Humans; Leupeptins; Liver; Neuroglia; Oligopeptides; Proteasome Inhibitors; Rats

2004
Coordination of oxidized protein hydrolase and the proteasome in the clearance of cytotoxic denatured proteins.
    Biochemical and biophysical research communications, 2004, Nov-05, Volume: 324, Issue:1

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Animals; Chlorocebus aethiops; COS Cells; Cysteine Proteinase Inhibitors; HSP70 Heat-Shock Proteins; Oligopeptides; Oxidation-Reduction; Oxidative Stress; Paraquat; Peptide Hydrolases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Denaturation; Tubulin; Vimentin

2004
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
    Blood, 2005, Apr-15, Volume: 105, Issue:8

    Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspases; Cell Survival; Complement Membrane Attack Complex; Complement System Proteins; Cysteine Proteinase Inhibitors; Cytochromes c; Gene Expression; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Leupeptins; Lymphocytes; Mitochondria; Mitochondrial Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA Interference

2005
Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition.
    Journal of neurochemistry, 2005, Volume: 93, Issue:5

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Apoptosis; Cells, Cultured; Dopamine; HSP70 Heat-Shock Proteins; Inclusion Bodies; Mesencephalon; Nerve Tissue Proteins; Neurons; Oligopeptides; Proteasome Inhibitors; Rats; Synucleins; Transcription, Genetic; Ubiquitin; Up-Regulation

2005
Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme.
    Journal of virology, 2005, Volume: 79, Issue:20

    Topics: Acetylcysteine; Cell Line; Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Gene Products, env; Glucosidases; Hepatitis B virus; Humans; Oligopeptides; Proteasome Endopeptidase Complex; Virus Replication

2005
Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells.
    Immunology, 2007, Volume: 120, Issue:1

    Topics: Acetylcysteine; Apoptosis; Boronic Acids; Bortezomib; Cell Differentiation; Chymases; Cysteine Proteinase Inhibitors; Dendritic Cells; Endocytosis; Humans; Interleukin-12; Lymphocyte Activation; Monocytes; Oligopeptides; Pinocytosis; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Receptors, Cell Surface

2007
Detection of a proteasome in Pneumocystis carinii and its modulation by specific proteasome inhibitors.
    The Journal of eukaryotic microbiology, 2006, Volume: 53 Suppl 1

    Topics: Acetylcysteine; Animals; Boronic Acids; Bortezomib; Cell Line; Coumarins; Genes, Fungal; HIV Protease Inhibitors; Humans; Lopinavir; Models, Animal; Oligopeptides; Pneumocystis carinii; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Pyrimidinones; Rats

2006
Specific blockage of ligand-induced degradation of the Ah receptor by proteasome but not calpain inhibitors in cell culture lines from different species.
    Biochemical pharmacology, 2007, Jun-30, Volume: 74, Issue:1

    Topics: Acetylcysteine; Acrylates; Animals; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytochrome P-450 CYP1A1; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Antagonism; Drug Combinations; Environmental Pollutants; Humans; Mice; Oligopeptides; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon

2007
Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systems.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:6

    Topics: Acetylcholine; Acetylcysteine; Aged; Aged, 80 and over; alpha-Synuclein; Animals; Basal Nucleus of Meynert; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinergic Fibers; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Lewy Bodies; Lewy Body Disease; Male; Nerve Degeneration; Nerve Tissue Proteins; Neural Pathways; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats; Rats, Sprague-Dawley; Ubiquitin

2008
Consequences of the DYT1 mutation on torsinA oligomerization and degradation.
    Neuroscience, 2008, Dec-02, Volume: 157, Issue:3

    Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Molecular Chaperones; Mutation; Oligopeptides; Time Factors; Transfection

2008
Effect of proteasome inhibitors with different chemical structures on the ubiquitin-proteasome system in vitro.
    Veterinary pathology, 2010, Volume: 47, Issue:2

    Topics: Acetylcysteine; Animals; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Immunohistochemistry; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Oligopeptides; PC12 Cells; Peripheral Nervous System Diseases; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats; Ubiquitin

2010
Regulation of aurora B kinase by the lipid raft protein flotillin-1.
    The Journal of biological chemistry, 2010, Jul-02, Volume: 285, Issue:27

    Topics: Acetylcysteine; Anti-Bacterial Agents; Aurora Kinase B; Aurora Kinases; Cell Division; Cell Nucleus; CREST Syndrome; DNA Primers; Down-Regulation; Gene Knockdown Techniques; HeLa Cells; Humans; In Situ Nick-End Labeling; Inhibitor of Apoptosis Proteins; Membrane Proteins; Microtubule-Associated Proteins; Oligopeptides; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Survivin; Transfection

2010
Semi-high throughput method of measuring proteasome inhibition in vitro and in cultured cells.
    Cell biology and toxicology, 2011, Volume: 27, Issue:2

    Topics: Acetylcysteine; Animals; Biological Assay; Boronic Acids; Bortezomib; Cell Extracts; Cells, Cultured; Chymotrypsin; High-Throughput Screening Assays; Inhibitory Concentration 50; Leupeptins; Mice; Models, Biological; Oligopeptides; Ornithine Decarboxylase; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins; Time Factors

2011
Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase.
    Parasitology, 2011, Volume: 138, Issue:9

    Topics: Acetylcysteine; Cell Culture Techniques; Cloning, Molecular; Cycloheximide; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Gene Expression; Immunoprecipitation; Kinetics; Leishmania donovani; Leishmaniasis, Visceral; Leupeptins; Methionine Adenosyltransferase; Oligopeptides; Plasmids; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; S-Adenosylmethionine; Transfection; Ubiquitin

2011
Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture.
    Journal of neural transmission (Vienna, Austria : 1996), 2012, Volume: 119, Issue:12

    Topics: Acetylcysteine; alpha-Synuclein; Animals; Blotting, Western; Cells, Cultured; Cysteine Proteinase Inhibitors; Immunohistochemistry; Lewy Body Disease; Neurons; Neuropeptides; Oligopeptides; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Synapses; Synaptophysin; Tubulin; Ubiquitination

2012
High sensitivity of embryonic stem cells to proteasome inhibitors correlates with low expression of heat shock protein and decrease of pluripotent cell marker expression.
    BMB reports, 2012, Volume: 45, Issue:5

    Topics: Acetylcysteine; Animals; Biomarkers; Cell Differentiation; Cells, Cultured; Cysteine Proteinase Inhibitors; Down-Regulation; Drug Resistance; Embryonic Stem Cells; Gene Expression Regulation, Developmental; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Leupeptins; Mice; Oligopeptides; Pluripotent Stem Cells; Proteasome Inhibitors

2012
Purification of large cytosolic proteases for in vitro assays: 20S and 26S proteasomes.
    Methods in molecular biology (Clifton, N.J.), 2013, Volume: 960

    Topics: Acetylcysteine; Adsorption; Ammonium Sulfate; Blotting, Western; Chemical Fractionation; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Cytosol; Dialysis; Electrophoresis, Polyacrylamide Gel; Enzyme Assays; Erythrocytes; Glycerol; Humans; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Ultracentrifugation

2013
The ubiquitin-proteasome system regulates the stability and activity of the glucose sensor glucokinase in pancreatic β-cells.
    The Biochemical journal, 2013, Dec-01, Volume: 456, Issue:2

    Topics: Acetylcysteine; Animals; Chlorocebus aethiops; COS Cells; Cycloheximide; Glucokinase; Glucose; Hepatocytes; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Leupeptins; Mice; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proteolysis; Single-Cell Analysis; Ubiquitin; Ubiquitination

2013
The effects of proteasomal inhibition on synaptic proteostasis.
    The EMBO journal, 2016, 10-17, Volume: 35, Issue:20

    Topics: Acetylcysteine; Animals; Cells, Cultured; Female; Male; Nerve Tissue Proteins; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Proteolysis; Rats, Wistar; Synapses; Ubiquitin

2016
Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells.
    The Journal of biological chemistry, 2018, 09-14, Volume: 293, Issue:37

    Topics: Acetylcysteine; Animals; Cell Line, Tumor; Diabetes Mellitus, Type 2; Down-Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Insulin-Secreting Cells; Insulinoma; Islet Amyloid Polypeptide; Leupeptins; Mice; Oligopeptides; Promoter Regions, Genetic; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats

2018