acetylcysteine has been researched along with cytochrome c-t in 139 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 73 (52.52) | 29.6817 |
| 2010's | 63 (45.32) | 24.3611 |
| 2020's | 3 (2.16) | 2.80 |
| Authors | Studies |
|---|---|
| Lum, MG; Nagley, P | 1 |
| Bardini, P; Danni, O; Guglielmotto, M; Marra, L; Parola, M; Santoro, G; Tabaton, M; Tamagno, E | 1 |
| Calvaruso, G; D'Anneo, A; Emanuele, S; Giuliano, M; Lauricella, M; Tesoriere, G; Vento, R | 1 |
| Fu, J; Zhang, S; Zhou, Z | 1 |
| Ayroldi, E; Bartoli, A; Bruscoli, S; Marconi, P; Rosati, E; Rossi, R; Sabatini, R; Simoncelli, C; Tabilio, A | 1 |
| Chen, YC; Ko, CH; Shen, SC | 1 |
| Columbano, A; Cossu, C; Ledda-Columbano, GM; Molotzu, F; Pibiri, M; Sanna, L; Simbula, G | 1 |
| Arriaza, E; Cara, C; Di Paola, M; Escribano, O; Fernández-Moreno, MD; Fueyo, JA; Guijarro, LG; Lorusso, M; Menor, C; Olleros, T; Román, ID | 1 |
| Fujii, M; Hou, DX; Imamura, I; Ose, T; Takeshita, T; Tanigawa, S; Tong, X; Uto, T | 1 |
| Choi, HS; Kuver, R; Lee, SP; Seo, DW | 1 |
| Bang, JH; Han, ES; Lee, CS; Lim, I | 1 |
| de Sousa, G; Orsini, N; Rahmani, R; Risso-de Faverney, C | 1 |
| Aiuchi, T; Hori, K; Horie, M; Kajimoto, S; Masuda, Y; Nakajo, S; Nakaya, K; Shibayama-Imazu, T; Shima, G | 1 |
| Lang-Rollin, I; Rideout, HJ; Stefanis, L; Vekrellis, K; Wang, Q | 1 |
| Nieminen, AL; Qanungo, S; Wang, M | 1 |
| Fujita, H; Inoue, A; Kanno, T; Muranaka, S; Tamai, H; Utsumi, K | 1 |
| Lin, CC; Ng, LT; Wu, SJ | 2 |
| Kim, CW; Kim, H; Kim, YN | 1 |
| Ballestrero, A; Barbieri, E; Belka, C; Brossart, P; Cardone, MH; Dillon, CP; Garuti, A; Hua, F; Nencioni, A; Patrone, F; Rocco, I; Scheiermann, C; Wesselborg, S; Yokoo, R | 1 |
| Hoffman-Goetz, L; Quadrilatero, J | 3 |
| Hu, Z; Lelli, KM; Maines, MD; Miralem, T; Torno, MD | 1 |
| Antosiewicz, J; Choi, S; Herman-Antosiewicz, A; Johnson, CS; Lee, YJ; Lew, KL; Singh, SV; Srivastava, SK; Trump, DL; Watkins, SC; Xiao, D; Xiao, H; Zeng, Y | 1 |
| Akaike, T; Bessho, T; Hirobe, C; Imai, M; Ohyama, K; Toyoda, H | 1 |
| Briggs, JP; Hoidal, JR; Honeggar, M; Kohan, DE; Mizel, D; Sanders, K; Schnermann, JB; Yang, T; Zhang, A | 1 |
| Kim, IS; Park, SJ | 1 |
| Delaney, AB; Douglas, L; Houghton, JA; Izeradjene, K; Tillman, DM | 1 |
| Jabado, O; Lang-Rollin, I; Maniati, M; Papantonis, S; Rideout, HJ; Stefanis, L; Vekrellis, K | 1 |
| Blank, N; Gaipl, US; Herrmann, M; Heyder, P; Kalden, JR; Lorenz, HM; Schiller, M | 1 |
| Cho, SJ; Lovrić, J; Maysinger, D; Winnik, FM | 1 |
| Han, ES; Kim, YJ; Ko, HH; Lee, CS | 1 |
| Burke, JR; Puranam, KL; Strittmatter, WJ; Wu, G | 1 |
| Deshpande, VS; Kehrer, JP | 2 |
| Agarwal, C; Agarwal, R; Kaur, M | 1 |
| Al-Humadi, NH; Hu, S; Ma, JK; Yin, XJ; Zhao, H | 1 |
| Lim, HS; Lu, XY; Paz, J; Yao, H; Zhang, W | 1 |
| Bajt, ML; Cover, C; Jaeschke, H; Lemasters, JJ | 1 |
| Cao, JM; Ding, JM; Gao, X; Liu, Y; Pang, J; Peng, X; Xu, X; Zhang, C | 1 |
| Choi, YM; Hur, DY; Kang, JS; Kim, YI; Kim, YS; Kwon, OS; Lee, WJ; Park, GB; Song, HK | 1 |
| Columbano, A; Deidda, M; Diana, A; Ledda-Columbano, GM; Pibiri, M; Sanna, L; Simbula, G | 1 |
| Booy, EP; Eshraghi, M; Ghavami, S; Hashemi, M; Los, M | 1 |
| Albini, A; Arena, G; D'Arrigo, C; Mormino, M; Noonan, DM; Poggi, A; Tosetti, F; Venè, R | 1 |
| Ceña, V; Posadas, I; Prieto-Lloret, J; Santos, P; Vellecco, V | 1 |
| Bindoli, A; Folda, A; Gandin, V; Marzano, C; Rigobello, MP; Scutari, G | 1 |
| Devarajan, P; Erkan, E; Schwartz, GJ | 1 |
| Bredesen, DE; Egger, L; Madden, DT; Rao, RV; Rhême, C | 1 |
| Chi, ZQ; Ju, YW; Li, Q; Lin, X; Liu, JG; Wang, MW; Wang, YJ | 1 |
| Ahmed, K; Feril, LB; Kondo, T; Matsuya, Y; Nemoto, H; Yu, DY; Zhao, QL | 1 |
| Bowen, ME; Bratton, SB; Fisher, AA; Gokhale, V; Labenski, MT; Lau, SS; Malladi, S; Milleron, RS; Monks, TJ | 1 |
| Hallak, M; Levy, I; Mazar, J; Nathan, I; Shpilberg, O; Vazana, L | 1 |
| Aw, TY; Circu, ML; Maloney, R; Moyer, MP; Rodriguez, C | 1 |
| Duan, S; Ge, J; He, Y; Jiang, RZ; Leung, KW; Peng, Z; Tombran-Tink, J; Zhang, YH; Zhong, XF | 1 |
| Chang, LS; Chen, KC; Lin, SR | 1 |
| Chen, T; Wong, YS | 1 |
| Chiang, CK; Huang, JW; Hung, KY; Kao, SH; Liu, SY; Tsai, TJ | 1 |
| Du, Y; Fan, X; Le, W; Li, X; Luo, G; Yang, D | 1 |
| Chen, Y; Dong, L; Fu, J; Li, H; Liu, S; Ren, Y; Tang, S; Wang, H; Wang, X; Wu, M | 1 |
| Hazra, B; Kumar, A; Kumar, B; Mishra, KP; Pandey, BN | 1 |
| Ahmed, K; Kondo, T; Matsuya, Y; Nemoto, H; Shimizu, T; Sugiyama, T; Yoshihisa, Y; Zaidi, SF | 1 |
| Hirayama, A; Inanami, O; Kobayashi, S; Kon, Y; Kuwabara, M; Meike, S; Ogura, A; Oowada, S; Yasui, H | 1 |
| Cai, YQ; Liu, CW; Zhang, SP; Zhou, YJ | 1 |
| Kumar, S; Sitasawad, SL | 1 |
| Das, T; Finke, JH; Hilston, CM; Moon, C; Rayman, PA; Rini, BI; Sa, G; Tannenbaum, CS | 1 |
| Guo, Q; Liu, W; Lu, N; Nie, F; Qi, Q; Wu, Z; Yang, L; Yang, Y; You, Q; Zhang, X | 1 |
| Lee, WY; Liu, KW; Yeung, JH | 1 |
| Kalariya, NM; Ramana, KV; Srivastava, SK; van Kuijk, FJ; Wills, NK | 1 |
| Li, B; Li, X; Sun, G; Wang, H; Wang, Y; Xu, Y; Xue, P; Zheng, Q | 1 |
| Chen, Y; Ji, L; Liu, T; Wang, Z | 1 |
| Galindo, MF; Jordán, J; Manzanares, J; Perez-Alvarez, S; Solesio, ME | 1 |
| Kim, YH; Moon, EY; Oh, JM; Ryoo, IJ; Yoo, ID | 1 |
| Li, D; Liu, C; Lu, C; Ma, X; Yao, N; Yu, A; Yuan, X; Zhang, C | 1 |
| Kurita-Ochiai, T; Ochiai, K | 1 |
| Choi, YJ; Hong, SH; Joe, YA; Kim, BM; Lee, YH | 1 |
| Giannattasio, S; Guaragnella, N; Marra, E; Passarella, S | 1 |
| Chen, RM; Chen, TG; Chen, TL; Cherng, YG; Chuang, CY; Tai, YT | 1 |
| Chandel, NS; Kondapalli, J; Loor, G; Schriewer, JM; Schumacker, PT; Vanden Hoek, TL | 1 |
| Agrawal, M; Bala Bhaskar, AS; Gupta, N; Lakshmana Rao, PV; Ravindran, J | 1 |
| Banerjee, A; Banks, WA; Ercal, N; Manda, KR | 1 |
| Cao, XH; Hou, LH; Liu, DY; Niu, LL; Wang, CL; Wang, Z; Zhao, SS | 1 |
| Hu, Y; Shi, Y; Song, Y; Wang, Y; Yang, K; Yu, H | 1 |
| Chen, CY; Chen, KT; Chen, TL; Chuang, YH; Chung, JG; Hour, MJ; Kuo, SC; Lu, CC; Yang, JS | 1 |
| Bhushan, S; Kaur, J; Kumar, A; Malik, F; Mondhe, DM; Pal, HC; Shah, BA; Singh, J; Taneja, SC; Wani, ZA | 1 |
| Tang, X; Wang, C; Xiao, G; Yao, C | 1 |
| Balazs, L; Bezawada, L; Ghosh, MC; Gorantla, VK; Luellen, C; Makena, PS; Parthasarathi, K; Sinclair, SE; Waters, CM | 1 |
| Castigli, E; Coaccioli, S; Corazzi, L; Davidescu, M; Macchioni, L; Marchetti, C; Migliorati, G; Roberti, R; Sciaccaluga, M | 1 |
| Hyun, DH; Kang, JS; Koh, HC; Lee, JE; Lee, KS; Lee, SJ; Shin, IC | 1 |
| Fan, J; Ji, Z; Liao, J; Liu, H; Peng, H; Wu, J; Zhang, Y; Zhao, S | 1 |
| Chen, ZQ; Fu, SB; Huang, Z; Li, JH; Liu, JY; Ren, FB; Yue, W; Zhan, Q | 1 |
| Capasso, A; D'Acunto, CW; Festa, M; Masullo, M; Piacente, S; Pizza, C; Rossi, AG | 1 |
| Ahmad, I; Kumar, A; Kumar, V; Pandey, HP; Patel, DK; Shukla, S; Singh, BK; Singh, C; Srivastava, G | 1 |
| Jiang, YF; Qu, SC; Qu, XR; Sui, da Y; Xu, HL; Yu, XF | 1 |
| Hota, KB; Hota, SK; Singh, SB; Srivastava, RB | 1 |
| Aslan, M; Cort, A; Dursun, E; Kucuksayan, E; Ozben, T; Timur, M | 1 |
| Chen, PY; Chiou, SM; Chiu, CH; Chung, JG; Huang, HY; Kuo, CL; Yang, JS; Yang, ST | 1 |
| Agharahimi, M; Badisa, RB; Goodman, CB; Mazzio, E; Oriaku, ET; Russell, LH; Zhu, ZP | 1 |
| Liu, X; Liu, Z; Qiao, Y; Xiang, Q; Xu, L; Yuan, L | 1 |
| Antonacci, L; Giannattasio, S; Guaragnella, N; Marra, E; Passarella, S; Ždralevic, M | 1 |
| Geng, C; Gong, D; Ishikawa, N; Jiang, L; Kajima, K; Li, L; Zhong, L | 1 |
| Choi, BT; Choi, YH; Jeong, JW; Jeong, YK; Kang, BW; Kim, GY; Kim, MJ; Lee, HH; Park, C; Park, JU; Seo, MJ | 1 |
| Liu, X; Wang, J; Wang, Y; Xiao, C; Xiao, H; Yuan, L | 1 |
| Damodaran, C; Das, TP; Suman, S | 1 |
| He, W; Li, Q; Liu, T; Zhang, B; Zhang, L; Zu, Y | 1 |
| Gao, H; Peng, J; Wang, H | 1 |
| Chao, JI; Chen, C; Liao, WS; Murugan, K; Wu, YH; Yang, CR | 1 |
| Bruno, RS; Chong, L; Freake, HC; Sankavaram, K | 1 |
| Koh, HC; Lee, JE; Lim, MS; Park, CH; Park, JH | 1 |
| Ban, JB; Chen, C; Fan, XW; Huang, Q; Li, BF; Xu, SQ; Zhang, HC | 1 |
| Hung, KY; Kao, SH; Liao, TL; Liu, SY; Yang, TC | 1 |
| Chen, H; Jia, H; Jin, L; Jin, Y; Tian, M | 1 |
| Adir, N; Ankonina, G; Dotan, H; Kallmann, D; Larom, S; Pinhassi, R; Rothschild, A; Saper, G; Schuster, G | 1 |
| Cha, BK; Hwang, KE; Hwang, YR; Jeong, ET; Kim, BR; Kim, HR; Kim, YS; Kwon, SJ; Park, DS; Yoon, KH | 1 |
| Aljada, A; Aziz, MA; El-Abadelah, MM; Nasr, A; Sabri, SS; Saleh, AM; Zahra, JA | 1 |
| Li, CJ; Pang, CY; Sun, LY | 1 |
| Baek, JY; Choi, YH; Go, SI; Jeong, JW; Kim, GS; Kim, GY; Kim, HJ; Kwon, TK; Lee, JD; Lee, SJ; Lee, WS; Nagappan, A; Park, C; Ryu, CH; Shin, SC | 1 |
| Cui, D; Ding, S; He, Q; Ji, L; Qi, Z; Qian, S; Sun, Y | 1 |
| Almosnid, NM; Altman, E; Chippada-Venkata, UD; Farone, A; Gao, Y; Gong, Y; Hosain, NA; Huang, R; Park, HS; Vick, E; Wen, Q | 1 |
| Da Silva, EP; Lambertucci, RH | 1 |
| Choi, IW; Choi, YH; Hwang, HJ; Kim, BW; Kim, CM; Kim, GY; Kim, WJ; Yoo, YH; Yu, GJ | 1 |
| Shang, CH; Zhang, QQ; Zhou, JH | 1 |
| Banerjee, S; Bose, D; Chatterjee, N; Das, S; Saha, KD | 1 |
| Bi, X; He, X; Xu, M; Yu, X; Zang, W; Zhao, M | 1 |
| Hu, Z; Ren, L; Wang, Z; Xiong, Y; Zhou, Y | 1 |
| Guan, G; Huang, B; Shao, F; Tan, B; Wu, M; Xiao, H; Yin, Y | 1 |
| Chang, X; Han, A; Li, J; Liu, F; Su, L; Sun, Y; Zhu, A; Zou, L | 1 |
| Chen, JX; Ding, KF; Du, CJ; Gao, F; Hu, SM; Li, SJ; Li, Y; Mao, XW; Miyamoto, H; Wen, JM; Zhang, N; Zhang, SG | 1 |
| El-Kabbani, O; Endo, S; Ikari, A; Kamata, K; Matsunaga, T; Miyazono, H; Morikawa, Y; Sasajima, Y; Sato, K; Shibata, A; Suenami, K; Takekoshi, Y | 1 |
| Deshidi, R; Jaglan, S; Koul, M; Kumar, A; Shah, BA; Sharma, PR; Sharma, V; Singh, J; Singh, RD; Singh, S | 1 |
| Cai, Z; Cheng, C; Han, W; Li, W; Ma, J; Shen, J; Yu, KN; Zhou, F | 1 |
| Liu, K; Liu, Y; Wang, N; Zhang, H | 1 |
| Han, L; Ma, XL; Song, RD; Wang, LL; Yu, QL; Zhang, WH; Zhao, SN | 1 |
| An, J; Chen, C; Guo, S; Li, H; Liu, Y; Shang, Y; Wang, C; Wang, X; Xia, H; Yu, J; Zhang, Y | 1 |
| Guo, L; Jin, J; Li, J; Sheng, X; Wu, M; Xia, Y; Xu, T; Zhang, C; Zhao, L | 1 |
| Chou, CH; Lin, WC; Lin, YH; Tsai, IJ; Tsau, YK; Tseng, YL; Yang, YH | 1 |
| Jin, W; Lu, S; Shi, H; Shu, Y; Wang, X | 1 |
| Ahmed, NS; El-Seedy, AS; Ezz El-Din, EM; Osman, KA | 1 |
| Ali, T; Arshad, M; Bashir, Z; Fatima, T; Ishtiaq, A; Khan, U; Khan, W; Murtaza, I; Mushtaq, I; Nawaz, M; Sarwar, M; Tabassum, S; Valadi, H | 1 |
139 other study(ies) available for acetylcysteine and cytochrome c-t
| Article | Year |
|---|---|
Two phases of signalling between mitochondria during apoptosis leading to early depolarisation and delayed cytochrome c release.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Calcium Signaling; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; Egtazic Acid; Green Fluorescent Proteins; Humans; Luminescent Proteins; Microscopy, Confocal; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; Signal Transduction; Time Factors | 2003 |
Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.
Topics: Acetylcysteine; alpha-Tocopherol; Amyloid beta-Peptides; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cell Differentiation; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2003 |
Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antioxidants; Apoptosis; bcl-X Protein; Blotting, Western; Caspase 3; Caspase 8; Caspases; Cell Line, Tumor; Cell Survival; Cysteine Endopeptidases; Cytochromes c; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leupeptins; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Multienzyme Complexes; Osteosarcoma; Protease Inhibitors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Retinoblastoma Protein; Time Factors; Transfection; Tumor Suppressor Protein p53 | 2003 |
In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain.
Topics: Acetylcysteine; Animals; Ascorbic Acid; Brain; Chlorides; Cytochromes c; Dose-Response Relationship, Drug; Drug Combinations; Electron Transport; Glutathione; Manganese Compounds; Membrane Potentials; Mitochondria; NADH, NADPH Oxidoreductases; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rhodamine 123; Succinate Dehydrogenase; Ubiquinone | 2004 |
Apoptosis of human primary B lymphocytes is inhibited by N-acetyl-L-cysteine.
Topics: Acetylcysteine; Antiviral Agents; Apoptosis; B-Lymphocytes; Blotting, Western; Caspase 3; Caspase 7; Caspases; Cells, Cultured; Cytochromes c; Humans; Palatine Tonsil; Time Factors | 2004 |
Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species.
Topics: Acetylcysteine; Allopurinol; Antioxidants; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins; Caspase 3; Caspases; Catalase; Cytochromes c; DNA Fragmentation; Flavanones; Flow Cytometry; Genes, bcl-2; Guanine Nucleotide Dissociation Inhibitors; HL-60 Cells; Humans; Hydroxylation; Male; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; rho Guanine Nucleotide Dissociation Inhibitor beta; rho-Specific Guanine Nucleotide Dissociation Inhibitors; Superoxide Dismutase | 2004 |
The peroxisome proliferator BR931 kills FaO cells by p53-dependent apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytosol; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Genes, p53; Humans; In Situ Nick-End Labeling; Liver Neoplasms, Experimental; Mitochondria; Peroxisome Proliferators; Phosphorylation; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Rats; Time Factors | 2004 |
Azathioprine acts upon rat hepatocyte mitochondria and stress-activated protein kinases leading to necrosis: protective role of N-acetyl-L-cysteine.
Topics: Acetylcysteine; Animals; Apoptosis; Azathioprine; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA; DNA Fragmentation; Glutathione; Hepatocytes; JNK Mitogen-Activated Protein Kinases; Male; Mitochondria, Liver; Mitogen-Activated Protein Kinase 3; Necrosis; Oxygen Consumption; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Stress, Physiological; Superoxides; Tetrazolium Salts; Thiazoles; Thymidine; Tritium | 2004 |
Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis.
Topics: Acetylcysteine; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspases; Catalase; Cell Survival; Contraceptive Agents, Male; Cytochromes c; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Flow Cytometry; Gossypol; HL-60 Cells; Humans; Membrane Potentials; Mitochondria; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Subcellular Fractions; Time Factors | 2004 |
Oxysterols from human bile induce apoptosis of canine gallbladder epithelial cells in monolayer culture.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Bile; Cells, Cultured; Cholesterol; Cytochromes c; Dogs; Dose-Response Relationship, Drug; Epithelial Cells; Flow Cytometry; Gallbladder; Humans; Microscopy, Fluorescence; Mitochondria; Sterols; Subcellular Fractions | 2004 |
Differential response of MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Small Cell; Caspase 3; Caspases; Cell Survival; Cytochromes c; DNA Damage; Drug Interactions; Enzyme Activation; Glutathione; Humans; Leupeptins; Membrane Potentials; Mitochondria; Oxidation-Reduction; Tumor Cells, Cultured | 2004 |
Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Cadmium; Caspases; Cyclic N-Oxides; Cytochromes c; Dose-Response Relationship, Drug; Hepatocytes; Mitochondria; Oncorhynchus mykiss; Oxidative Stress; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Statistics, Nonparametric; Time Factors | 2004 |
Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Line, Tumor; Coloring Agents; Cytochromes c; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; Gene Expression Regulation; Genetic Vectors; HL-60 Cells; HSP90 Heat-Shock Proteins; Humans; K562 Cells; Mitochondria; Naphthoquinones; Oligonucleotide Array Sequence Analysis; Plasmids; Reactive Oxygen Species; RNA, Small Interfering; Subcellular Fractions; Time Factors; Transfection | 2004 |
Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Blotting, Western; Carrier Proteins; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Ganglia, Sympathetic; Genes, bcl-2; Green Fluorescent Proteins; Immunohistochemistry; Luminescent Proteins; Membrane Proteins; Mice; Mice, Knockout; Multienzyme Complexes; Neurons; Oligopeptides; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rhodamines; Signal Transduction; Time Factors; Ubiquitin | 2004 |
N-Acetyl-L-cysteine enhances apoptosis through inhibition of nuclear factor-kappaB in hypoxic murine embryonic fibroblasts.
Topics: Acetylcysteine; Animals; Apoptosis; Cell Survival; Cytochromes c; Fibroblasts; Glutathione; Hypoxia; I-kappa B Proteins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Proteins; Reactive Oxygen Species; X-Linked Inhibitor of Apoptosis Protein | 2004 |
Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
Topics: 2-Methoxyestradiol; Acetylcysteine; Amino Acid Chloromethyl Ketones; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Chromones; Cyclic AMP; Cyclosporine; Cysteine Proteinase Inhibitors; Cytochromes c; Diclofenac; DNA Fragmentation; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Estradiol; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2004 |
Effects of vitamin E on the cinnamaldehyde-induced apoptotic mechanism in human PLC/PRF/5 cells.
Topics: Acetylcysteine; Acrolein; Annexin A5; Antioxidants; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Line; Cell Proliferation; Complement Membrane Attack Complex; Complement System Proteins; Cytochromes c; Cytosol; Enzyme Activation; Genes, bcl-2; Glycoproteins; High-Temperature Requirement A Serine Peptidase 2; Humans; Indicators and Reagents; Mitochondria; Mitochondrial Proteins; Reactive Oxygen Species; Serine Endopeptidases; Signal Transduction; Vitamin E | 2004 |
Oxidative stress attenuates Fas-mediated apoptosis in Jurkat T cell line through Bfl-1 induction.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antioxidants; Apoptosis; Cytochromes c; fas Receptor; Gene Expression; Genes, bcl-2; Humans; Hydrogen Peroxide; Jurkat Cells; Minor Histocompatibility Antigens; Mitochondria; NF-kappa B; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; T-Lymphocytes; Up-Regulation | 2005 |
Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspases; Cell Survival; Complement Membrane Attack Complex; Complement System Proteins; Cysteine Proteinase Inhibitors; Cytochromes c; Gene Expression; Glycoproteins; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Leupeptins; Lymphocytes; Mitochondria; Mitochondrial Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oligopeptides; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA Interference | 2005 |
N-acetyl-L-cysteine inhibits exercise-induced lymphocyte apoptotic protein alterations.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cytochromes c; Exercise Test; Female; Lymphocytes; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-bcl-2; Random Allocation | 2005 |
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Arsenites; Biliverdine; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Cytochromes c; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Silencing; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Luciferases; Membrane Glycoproteins; Membrane Proteins; Oligonucleotides; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Phosphorylation; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Retroviridae; RNA, Messenger; RNA, Small Interfering; Serine; Sodium Compounds; Threonine; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspase 8; Caspases; Cell Line, Tumor; Cells, Cultured; Cytochromes c; Enzyme Activation; Humans; Isothiocyanates; Male; Membrane Potentials; Mice; Mice, Knockout; Mitochondria; Models, Biological; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sulfoxides; Thiocyanates | 2005 |
Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Signet Ring Cell; Cell Line, Tumor; Cytochromes c; DNA Fragmentation; Fruit; Glutathione; Humans; Mitochondria; Oxidative Stress; Plant Extracts; Stomach Neoplasms; Vitex | 2005 |
In vivo corticosterone administration at levels occurring with intense exercise does not induce intestinal lymphocyte apoptosis in mice.
Topics: Acetylcysteine; Analysis of Variance; Animals; Annexin A5; Antigens, CD; Apoptosis; Benzimidazoles; Blotting, Western; Carbocyanines; Caspase 3; Caspases; Cell Survival; Corticosterone; Cytochromes c; Dose-Response Relationship, Drug; Drug Interactions; Female; Gene Expression Regulation; Glutathione; Hydrogen Peroxide; Intestines; Lymphocytes; Membrane Potentials; Mice; Mice, Inbred C57BL; Mitochondria; Phenotype; Physical Conditioning, Animal; Proto-Oncogene Proteins c-bcl-2; Time Factors | 2005 |
N-acetyl-l-cysteine protects intestinal lymphocytes from apoptotic death after acute exercise in adrenalectomized mice.
Topics: Acetylcysteine; Adrenalectomy; Animals; Antigens, Surface; Apoptosis; Blotting, Western; Caspase 3; Caspases; Corticosterone; Cytochromes c; Female; Flow Cytometry; Free Radical Scavengers; Glucocorticoids; Glutathione; Hydrogen Peroxide; Intestines; Lymphocytes; Membranes; Mice; Mice, Inbred C57BL; Oxidative Stress; Phosphatidylserines; Physical Exertion; Propidium; Proto-Oncogene Proteins c-bcl-2 | 2005 |
Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin.
Topics: Acetylcysteine; Animals; Antioxidants; Blotting, Western; Cells, Cultured; Cyclic N-Oxides; Cyclooxygenase 2; Cytochromes c; Dinoprostone; Fluoresceins; Genes, Dominant; Hydrazones; Kidney; Kidney Tubules, Collecting; MAP Kinase Signaling System; Membrane Glycoproteins; Mice; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NADPH Oxidase 2; NADPH Oxidases; Onium Compounds; Osmosis; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Reactive Oxygen Species; Rotenone; Thenoyltrifluoroacetone; Time Factors; Xanthine; Xanthine Oxidase | 2005 |
Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Carcinoma, Hepatocellular; Carrier Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Proliferation; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; fas Receptor; Flow Cytometry; Humans; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Liver Neoplasms; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Oligopeptides; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Time Factors; Tumor Suppressor Protein p53; Up-Regulation; Vitamin E; X-Linked Inhibitor of Apoptosis Protein | 2005 |
The role of p38 MAPK activation in auranofin-induced apoptosis of human promyelocytic leukaemia HL-60 cells.
Topics: Acetylcysteine; Antioxidants; Antirheumatic Agents; Apoptosis; Auranofin; Caspases; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Time Factors | 2005 |
Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Respiration; Colonic Neoplasms; Cytochromes c; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Membrane Glycoproteins; Mitochondria; Mitochondrial Proteins; Oxidative Phosphorylation; Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Uncoupling Agents; X-Linked Inhibitor of Apoptosis Protein | 2005 |
Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2.
Topics: Acetylcysteine; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-X Protein; Caspase 9; Cytochromes c; Gene Expression; Genes, Dominant; Membrane Proteins; Mitochondria; PC12 Cells; Proteasome Inhibitors; Protein Processing, Post-Translational; Protein Structure, Quaternary; Protein Transport; Proto-Oncogene Proteins; Rats | 2005 |
Induction of apoptosis by spermine-metabolites in primary human blood cells and various tumor cell lines.
Topics: Acetylcysteine; Amine Oxidase (Copper-Containing); Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Caspase Inhibitors; Cell Line, Tumor; Cytochromes c; Dexamethasone; fas Receptor; Humans; Hydrogen Peroxide; Intracellular Signaling Peptides and Proteins; Leukocytes, Mononuclear; Lymphoproliferative Disorders; Membrane Potentials; Mitochondria; Mitochondrial Proteins; Polyamines; Proto-Oncogene Proteins c-bcl-2; Putrescine; Reactive Oxygen Species; Spermidine; Spermine | 2005 |
Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death.
Topics: Acetylcysteine; Cadmium Compounds; Caspases; Cell Death; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cytochromes c; Humans; Mitochondria; Organelles; Quantum Dots; Reactive Oxygen Species; Tellurium | 2005 |
Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Apoptosis; Benzoates; Caspase 3; Caspases; Catalase; Cell Nucleus; Cell Survival; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione; Glyburide; Imidazoles; Mitochondrial Membranes; PC12 Cells; Permeability; Porphyrins; Rats; Reactive Oxygen Species; Tolbutamide | 2005 |
Polyglutamine expansion inhibits respiration by increasing reactive oxygen species in isolated mitochondria.
Topics: Acetylcysteine; Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antioxidants; Cytochromes c; Electron Transport; Electrophoresis, Polyacrylamide Gel; Liver; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial ADP, ATP Translocases; Mitochondrial Proton-Translocating ATPases; NADH Dehydrogenase; Oxidative Stress; Oxygen Consumption; Peptides; Reactive Oxygen Species | 2006 |
Oxidative stress-driven mechanisms of nordihydroguaiaretic acid-induced apoptosis in FL5.12 cells.
Topics: Acetylcysteine; Animals; Apoptosis; B-Lymphocytes; Caspase 3; Caspases; Cell Line; Cytochromes c; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Lipoxygenase Inhibitors; Masoprocol; Mice; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation | 2006 |
Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation.
Topics: Acetylcysteine; Anoikis; Anticarcinogenic Agents; Apoptosis; Apoptosis Inducing Factor; Ataxia Telangiectasia Mutated Proteins; Caspases; Cell Cycle Proteins; Checkpoint Kinase 2; Cytochromes c; DNA-Binding Proteins; Focal Adhesion Kinase 1; Histones; Humans; Male; Plant Extracts; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2006 |
Silica-induced apoptosis in alveolar macrophages: evidence of in vivo thiol depletion and the activation of mitochondrial pathway.
Topics: Acetylcysteine; Alkaloids; Animals; Anti-Inflammatory Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzylisoquinolines; Caspase 3; Caspases; Cysteine; Cytochromes c; Disease Models, Animal; Glutathione; Inflammation Mediators; Macrophages, Alveolar; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria; Oxidative Stress; Paclitaxel; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Silicon Dioxide; Sulfhydryl Compounds; Tumor Necrosis Factor-alpha | 2006 |
Mechanisms of N-acetylcysteine-driven enhancement of MK886-induced apoptosis.
Topics: 5-Lipoxygenase-Activating Proteins; Acetylcysteine; Annexin A5; Apoptosis; Carrier Proteins; Caspase 3; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Fluorescein-5-isothiocyanate; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; Indoles; Jurkat Cells; Membrane Proteins; Propidium | 2006 |
The neuroprotective role of attractin in neurodegeneration.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Analysis of Variance; Apoptosis Inducing Factor; Cell Line, Tumor; Cell Survival; Cytochromes c; Gene Expression Regulation; Humans; In Situ Hybridization; Membrane Proteins; Nerve Degeneration; Neurotoxins; RNA, Small Interfering; Transfection; Tyrosine 3-Monooxygenase | 2007 |
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
Topics: Acetaminophen; Acetylcysteine; Active Transport, Cell Nucleus; Animals; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Benzimidazoles; Carbocyanines; Carrier Proteins; Cell Nucleus; Cell Survival; Cells, Cultured; Cytochromes c; DNA Fragmentation; Endodeoxyribonucleases; Hepatocytes; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Mitochondria; Mitochondrial Proteins | 2006 |
NMDA receptor activation induces mitochondrial dysfunction, oxidative stress and apoptosis in cultured neonatal rat cardiomyocytes.
Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Calcium; Caspase 3; Cell Survival; Cells, Cultured; Cytochromes c; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutathione; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; N-Methylaspartate; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors | 2007 |
Ligation of centrocyte/centroblast marker 1 on Epstein-Barr virus--transformed B lymphocytes induces cell death in a reactive oxygen species--dependent manner.
Topics: Acetylcysteine; Actins; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Antioxidants; Apoptosis; Apoptosis Inducing Factor; B-Lymphocytes; Caspase Inhibitors; Caspases; Cell Nucleus; Cell Transformation, Viral; Cells, Cultured; Cytochalasin D; Cytochromes c; Endodeoxyribonucleases; Herpesvirus 4, Human; Humans; Membrane Potential, Mitochondrial; Mitochondria; Phosphatidylserines; Reactive Oxygen Species | 2006 |
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Cytochromes c; DNA Fragmentation; Enzyme Activation; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Thioctic Acid; Tumor Suppressor Protein p53 | 2007 |
Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells.
Topics: Acetylcysteine; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Survival; Chelating Agents; Cytochromes c; Ethylenediamines; Humans; Membrane Potentials; Mitochondria; Pentetic Acid; Receptors, Estrogen; Zinc | 2007 |
Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications.
Topics: Acetylcysteine; Adenosine Triphosphate; Antineoplastic Agents; Benzyl Compounds; Caspase Inhibitors; Cathepsin D; Cell Death; Cell Survival; Cytochromes c; Cytosol; Enzyme Activation; Flow Cytometry; Humans; Hydrocarbons, Fluorinated; Insulin-Like Growth Factor I; Lysosomes; Membrane Potential, Mitochondrial; Mitochondria; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Retinoblastoma; Time Factors; Tretinoin | 2007 |
Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.
Topics: Acetaminophen; Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochromes c; Dinoprostone; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Free Radical Scavengers; Glutathione; Humans; Metalloporphyrins; Neuroblastoma; Prostaglandin-Endoperoxide Synthases; Staurosporine; Time Factors | 2007 |
Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antirheumatic Agents; Apoptosis; Auranofin; Cell Line, Tumor; Cisplatin; Cytochromes c; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; Mitochondria; Ovarian Neoplasms; Thioredoxin-Disulfide Reductase | 2007 |
Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells.
Topics: Acetylcysteine; Albumins; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Cell Line; Cytochromes c; Humans; Kidney Tubules, Proximal; Low Density Lipoprotein Receptor-Related Protein-2; Membrane Potentials; Mitochondria; Protein Kinase C; Protein Transport; Reactive Oxygen Species | 2007 |
Endoplasmic reticulum stress-induced cell death mediated by the proteasome.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Brefeldin A; Caspase 3; Cells, Cultured; Chlorhexidine; Cytochromes c; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Fibroblasts; Mitochondrial Membranes; Models, Biological; Phosphatidylserines; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rats; Sulfones; Temperature; Ubiquitin-Activating Enzymes | 2007 |
Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kappaB transcriptional activation in neuroblastoma SH-SY5Y cells.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Cell Line, Tumor; Cytochromes c; Cytoprotection; Doxorubicin; Enzyme Activation; Humans; I-kappa B Kinase; Morphine; Neuroblastoma; NF-kappa B; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Transcriptional Activation | 2007 |
Rapid and transient intracellular oxidative stress due to novel macrosphelides trigger apoptosis via Fas/caspase-8-dependent pathway in human lymphoma U937 cells.
Topics: Acetylcysteine; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Caspase 8; Cytochromes c; fas Receptor; Flow Cytometry; Glutathione; Heterocyclic Compounds; Humans; Lipid Peroxidation; Membrane Potentials; Oxidative Stress; Reactive Oxygen Species; U937 Cells | 2007 |
Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.
Topics: Acetylcysteine; Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosomes; Benzoquinones; Caspase 3; Caspase 9; Cell Line, Tumor; Chromatography, Liquid; Circular Dichroism; Cytochromes c; Horses; Humans; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry | 2007 |
A molecular mechanism for mimosine-induced apoptosis involving oxidative stress and mitochondrial activation.
Topics: Acetylcysteine; Animals; Apoptosis; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mimosine; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; Rats; Reactive Oxygen Species | 2008 |
Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis.
Topics: Acetylcysteine; Antifibrinolytic Agents; Apoptosis; Biological Transport; Blotting, Western; Caspases; Cell Membrane; Cells, Cultured; Colon; Cytochromes c; Cytosol; Dicumarol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flow Cytometry; Free Radical Scavengers; Glutathione; Glutathione Disulfide; Humans; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Protein Transport; Vitamin K 3 | 2008 |
Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants.
Topics: Acetylcysteine; Adenosine Triphosphate; Adolescent; Adult; Annexin A5; Antioxidants; Apoptosis; Cells, Cultured; Cyclosporine; Cytochromes c; Electron Transport Complex I; Glaucoma, Open-Angle; Humans; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Middle Aged; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxidative Stress; Reactive Oxygen Species; Rotenone; Trabecular Meshwork; Uncoupling Agents; Vitamin E | 2008 |
Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.
Topics: Acetylcysteine; Apoptosis; Caspases; Cell Line, Tumor; Cobra Cardiotoxin Proteins; Cyclosporine; Cytochromes c; Elapid Venoms; Enzyme Activation; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Neuroblastoma; Reactive Oxygen Species; Rotenone; Uncoupling Agents | 2008 |
Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Caspases; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cystine; Cytochromes c; Female; Humans; Membrane Potential, Mitochondrial; Organoselenium Compounds; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tumor Suppressor Protein p53 | 2009 |
N-acetylcysteine-mediated antioxidation prevents hyperglycemia-induced apoptosis and collagen synthesis in rat mesangial cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Apoptosis; Caspases; Cells, Cultured; Collagen; Cytochromes c; Enzyme Activation; Extracellular Matrix; Free Radical Scavengers; Gene Expression; Hyperglycemia; Malondialdehyde; Mesangial Cells; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species; Transforming Growth Factor beta1 | 2009 |
c-Jun N-terminal kinase mediates lactacystin-induced dopamine neuron degeneration.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Line; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Cytochromes c; Dopamine; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Substantia Nigra; Tetrazolium Salts; Thiazoles | 2008 |
p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38 in HepG2 cells.
Topics: Acetylcysteine; Apoptosis; Cell Line, Tumor; Cytochromes c; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Models, Biological; p38 Mitogen-Activated Protein Kinases; Proteasome Endopeptidase Complex; Protein Transport; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; Subcellular Fractions | 2008 |
Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells.
Topics: Acetylcysteine; Allopurinol; Animals; Antimycin A; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cardiolipins; Cell Line, Tumor; Cyclosporine; Cytochromes c; Female; Free Radical Scavengers; Humans; Membrane Potential, Mitochondrial; Mitochondria; Naphthoquinones; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Rotenone; Uncoupling Agents; Vitamin K 3 | 2009 |
Mechanism of apoptosis induced by a newly synthesized derivative of macrosphelides with a thiazole side chain.
Topics: Acetylcysteine; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Calcium; Caspase 3; Caspase 8; Cell Division; Cytochromes c; Heterocyclic Compounds; Humans; MAP Kinase Kinase 4; Protein Kinase Inhibitors; Reactive Oxygen Species; Thiazoles; U937 Cells | 2009 |
Redox regulation in radiation-induced cytochrome c release from mitochondria of human lung carcinoma A549 cells.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspases; Cell Line, Tumor; Cytochromes c; Electron Spin Resonance Spectroscopy; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxides | 2009 |
The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells.
Topics: Acetylcysteine; Animals; Apoptosis; bcl-2-Associated X Protein; Cadmium Chloride; Cell Survival; Cytochromes c; Enzyme Activation; LLC-PK1 Cells; Membrane Potential, Mitochondrial; Mitochondria; Necrosis; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sodium Selenite; Swine | 2009 |
N-acetylcysteine prevents glucose/glucose oxidase-induced oxidative stress, mitochondrial damage and apoptosis in H9c2 cells.
Topics: Acetylcysteine; Animals; Apoptosis; Blotting, Western; Cell Line; Cytochromes c; Dose-Response Relationship, Drug; Glucose; Glucose Oxidase; Hyperglycemia; Membrane Potential, Mitochondrial; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Peroxynitrous Acid; Reactive Oxygen Species | 2009 |
GD3, an overexpressed tumor-derived ganglioside, mediates the apoptosis of activated but not resting T cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Carcinoma, Renal Cell; Caspase 8; Caspase 9; Caspase Inhibitors; Cell Line, Tumor; Cell Membrane Permeability; Cytochromes c; Gangliosides; Glioblastoma; Humans; Jurkat Cells; Kidney Neoplasms; Lymphocyte Activation; Mitochondrial Membranes; Reactive Oxygen Species; T-Lymphocytes | 2009 |
Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Cell Line, Tumor; Cell Survival; Cytochromes c; Flow Cytometry; Free Radical Scavengers; Glutathione; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Liver; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Signal Transduction; Xanthones | 2009 |
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Topics: Abietanes; Acetylcysteine; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Enzyme Activation; Furans; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; Liver Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinones; Reactive Oxygen Species; Time Factors | 2009 |
Cadmium-induced apoptotic death of human retinal pigment epithelial cells is mediated by MAPK pathway.
Topics: Acetylcysteine; Apoptosis; Blotting, Western; Buthionine Sulfoximine; Cadmium Chloride; Cell Line; Cell Survival; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Glutathione; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Retinal Pigment Epithelium; Time Factors | 2009 |
Arsenic induces mitochondria-dependent apoptosis by reactive oxygen species generation rather than glutathione depletion in Chang human hepatocytes.
Topics: Acetylcysteine; Apoptosis; Arsenic; Arsenites; Cell Survival; Cells, Cultured; Cytochromes c; Glutathione; Hepatocytes; Humans; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Sodium Compounds | 2009 |
Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity.
Topics: Acetylcysteine; Apoptosis; bcl-X Protein; Caspase 3; Caspase 9; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochromes c; Cytotoxins; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione; Glutathione Peroxidase; Glutathione Synthase; Glutathione Transferase; Hepatocytes; Humans; Pyrrolizidine Alkaloids; Reactive Oxygen Species; Thioredoxins | 2009 |
Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Cell Survival; Coloring Agents; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Green Fluorescent Proteins; Humans; Membrane Potential, Mitochondrial; Mitochondria, Liver; Neuroblastoma; Reactive Oxygen Species; Recombinant Fusion Proteins; Tetrazolium Salts; Thiazoles | 2009 |
Clitocybins, novel isoindolinone free radical scavengers, from mushroom Clitocybe aurantiaca inhibit apoptotic cell death and cellular senescence.
Topics: Acetylcysteine; Agaricales; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cellular Senescence; Cytochromes c; Free Radical Scavengers; Fungal Proteins; Humans; Hydrogen Peroxide; I-kappa B Proteins; Isoindoles; Mitochondria; NF-KappaB Inhibitor alpha | 2009 |
Intracellular redox imbalance and extracellular amino acid metabolic abnormality contribute to arsenic-induced developmental retardation in mouse preimplantation embryos.
Topics: Acetylcysteine; Amino Acids; Animals; Antioxidants; Apoptosis; Arsenites; Blastocyst; Caspases; Cytochromes c; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryonic Development; Environmental Pollutants; Enzyme Activation; Glutathione; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Time Factors | 2010 |
Butyric acid induces apoptosis via oxidative stress in Jurkat T-cells.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Butyric Acid; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 10; Caspase Inhibitors; Caspases, Initiator; Cysteine Proteinase Inhibitors; Cytochromes c; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Free Radical Scavengers; Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, Death Domain; Serpins; Signal Transduction; T-Lymphocytes; Viral Proteins | 2010 |
N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antibiotics, Antineoplastic; Antioxidants; Apoptosis Inducing Factor; Caspase Inhibitors; Caspases; Cell Survival; Cysteine Proteinase Inhibitors; Cytochromes c; Doxorubicin; Drug Resistance, Multiple; Enzyme Activation; Free Radical Scavengers; HL-60 Cells; Humans; Mitochondria; Reactive Oxygen Species; Sphingosine | 2010 |
Knock-out of metacaspase and/or cytochrome c results in the activation of a ROS-independent acetic acid-induced programmed cell death pathway in yeast.
Topics: Acetic Acid; Acetylcysteine; Antioxidants; Apoptosis; Caspase Inhibitors; Caspases; Cytochromes c; Gene Knockout Techniques; Genes, Fungal; Models, Biological; Mutation; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2010 |
Lipopolysaccharide induces apoptotic insults to human alveolar epithelial A549 cells through reactive oxygen species-mediated activation of an intrinsic mitochondrion-dependent pathway.
Topics: Acetylcysteine; Alveolar Epithelial Cells; Apoptosis; Caspase 6; Caspase 9; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cytochromes c; DNA Fragmentation; Enzyme Activation; Epithelial Cells; Humans; Lipopolysaccharides; Membrane Potential, Mitochondrial; Mitochondria; Nitric Oxide; Pulmonary Alveoli; Reactive Oxygen Species; Time Factors | 2011 |
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-X Protein; Cell Death; Cells, Cultured; Chick Embryo; Cyclophilins; Cytochromes c; Enzyme Activation; Fibroblasts; Glutathione; Green Fluorescent Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Myocytes, Cardiac; Oxidants; Oxidative Stress; Peptidyl-Prolyl Isomerase F; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Recombinant Proteins; Signal Transduction; Staurosporine; Vitamin K 3 | 2010 |
Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase 7; Caspase 9; Cell Line, Tumor; Cyclosporins; Cytochromes c; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Reactive Oxygen Species; U937 Cells | 2011 |
Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Antiretroviral Therapy, Highly Active; Apoptosis; Blood-Brain Barrier; Caspase 3; Cell Line, Transformed; Cytochromes c; Endothelial Cells; Glutathione; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Indinavir; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Zidovudine | 2011 |
ROS-Ca(2+) is associated with mitochondria permeability transition pore involved in surfactin-induced MCF-7 cells apoptosis.
Topics: Acetylcysteine; Apoptosis; Calcium; Caspase 9; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cytochromes c; Egtazic Acid; Humans; Lipopeptides; Membrane Potential, Mitochondrial; Mitochondria; Peptides, Cyclic; Reactive Oxygen Species | 2011 |
p,p'-Dichlorodiphenoxydichloroethylene induced apoptosis of Sertoli cells through oxidative stress-mediated p38 MAPK and mitochondrial pathway.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cell Survival; Cytochromes c; Dichlorodiphenyl Dichloroethylene; Gene Expression; Imidazoles; Insecticides; Male; Mitochondria; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells | 2011 |
The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells.
Topics: Acetylcysteine; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Apoptotic Protease-Activating Factor 1; Caspases; Cell Line, Tumor; Cyclosporine; Cytochromes c; DNA Fragmentation; Fas Ligand Protein; fas Receptor; Fas-Associated Death Domain Protein; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; Osteoblasts; Quinazolines; Reactive Oxygen Species; Signal Transduction | 2011 |
A novel parthenin analog exhibits anti-cancer activity: activation of apoptotic signaling events through robust NO formation in human leukemia HL-60 cells.
Topics: Acetylcysteine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Bridged-Ring Compounds; Caspase 3; Caspase 8; Caspase 9; Cytochromes c; Female; Glutathione; HL-60 Cells; Humans; Inhibitor of Apoptosis Proteins; Male; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; RNA Interference; RNA, Small Interfering; Sesquiterpenes; Signal Transduction; STAT3 Transcription Factor; Survivin | 2011 |
Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Survival; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Glutathione; HL-60 Cells; Humans; Intracellular Space; Jurkat Cells; Leukemia; Mitochondria; Oxides; Phosphorylation; Proto-Oncogene Proteins c-akt; Time Factors; U937 Cells; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Cell Line; Cytochromes c; Epithelial Cells; Hyperoxia; JNK Mitogen-Activated Protein Kinases; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mitochondria; Oxidants; Oxidative Stress; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Respiration, Artificial; Tidal Volume | 2011 |
Mitochondrial dysfunction and effect of antiglycolytic bromopyruvic acid in GL15 glioblastoma cells.
Topics: Acetylcysteine; Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Cytochromes c; Enzyme Inhibitors; Free Radical Scavengers; Glioblastoma; Glycolysis; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Oxidation-Reduction; Proteolysis; Pyruvates; Reactive Oxygen Species | 2011 |
Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins.
Topics: Acetylcysteine; Aminopyridines; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cytochromes c; Dose-Response Relationship, Drug; Electron Transport Complex I; Humans; Mitochondria; Neurons; Oxidative Stress; Pesticides; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Time Factors; Tumor Suppressor Protein p53 | 2011 |
Reactive oxygen species-mediated mitochondrial dysfunction is involved in apoptosis in human nasopharyngeal carcinoma CNE cells induced by Selaginella doederleinii extract.
Topics: Acetylcysteine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Disease Models, Animal; Female; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Selaginellaceae | 2011 |
Calcium overload induces C6 rat glioma cell apoptosis in sonodynamic therapy.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium; Caspase 3; Cytochromes c; Egtazic Acid; Fluorometry; Glioma; Hematoporphyrins; Immunoblotting; Intracellular Membranes; Necrosis; Photosensitizing Agents; Rats; Reactive Oxygen Species; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tumor Cells, Cultured; Ultrasonic Therapy | 2011 |
Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cyclohexenes; Cytochromes c; Dose-Response Relationship, Drug; Flavonoids; Glioblastoma; Humans; Imidazoles; Italy; Mitogen-Activated Protein Kinases; Molecular Structure; Poly(ADP-ribose) Polymerases; Propiophenones; Pyridines; Reactive Oxygen Species; Terpenes | 2011 |
Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: similarity with paraquat neurotoxicity.
Topics: Acetophenones; Acetylcysteine; Animals; Apoptosis; Caspases; CD11b Antigen; Corpus Striatum; Cytochromes c; Dopamine; Dopaminergic Neurons; Enzyme Inhibitors; Glutathione; Male; Membrane Glycoproteins; Mitochondria; Motor Activity; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Paraquat; Parkinsonian Disorders; Phosphoproteins; Rats; Rats, Wistar; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase | 2012 |
Juglone, from Juglans mandshruica Maxim, inhibits growth and induces apoptosis in human leukemia cell HL-60 through a reactive oxygen species-dependent mechanism.
Topics: Acetylcysteine; Annexin A5; Antioxidants; Apoptosis; Caspases; Cell Division; Cytochromes c; Enzyme Activation; Glutathione; HL-60 Cells; Humans; Juglans; Leukemia; Membrane Potentials; Naphthoquinones; Reactive Oxygen Species | 2012 |
Neuroglobin regulates hypoxic response of neuronal cells through Hif-1α- and Nrf2-mediated mechanism.
Topics: Acetylcysteine; Animals; Cell Hypoxia; Cell Survival; Cytochromes c; Free Radical Scavengers; Globins; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Nerve Tissue Proteins; Neurodegenerative Diseases; Neuroglobin; Neurons; NF-E2-Related Factor 2; Oxidation-Reduction; Proteolysis; Rats, Sprague-Dawley | 2012 |
Effects of N-acetylcystein on bleomycin-induced apoptosis in malignant testicular germ cell tumors.
Topics: Acetylcysteine; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Bleomycin; Caspases; Cell Line, Tumor; Cell Survival; Cytochromes c; Humans; Hydrogen Peroxide; Lethal Dose 50; Male; Neoplasms, Germ Cell and Embryonal; Oxidants; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Testicular Neoplasms | 2012 |
Danthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling.
Topics: Acetylcysteine; Animals; Anthraquinones; Apoptosis; Apoptosis Inducing Factor; Caspases; Cell Death; Cell Line, Tumor; Cytochromes c; Endodeoxyribonucleases; Glioma; Membrane Potential, Mitochondrial; Mitochondria; Rats; Reactive Oxygen Species; Signal Transduction | 2012 |
Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells.
Topics: Acetylcysteine; Apoptosis; Caspases; Cell Line, Tumor; Cytochromes c; Gallic Acid; Glutathione; Humans; Male; Membrane Potential, Mitochondrial; Oxidation-Reduction; Prostatic Neoplasms; Reactive Oxygen Species | 2012 |
Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cytochromes c; Dose-Response Relationship, Drug; Flavonoids; Heat-Shock Proteins; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Transcription Factors | 2013 |
The N-acetylcysteine-insensitive acetic acid-induced yeast programmed cell death occurs without macroautophagy.
Topics: Acetic Acid; Acetylcysteine; Alkaline Phosphatase; Antioxidants; Caspases; Cytochromes c; In Situ Nick-End Labeling; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2012 |
Monosodium iodoacetate induces apoptosis via the mitochondrial pathway involving ROS production and caspase activation in rat chondrocytes in vitro.
Topics: Acetylcysteine; Animals; Apoptosis; Cartilage, Articular; Caspase 3; Cell Survival; Chondrocytes; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Femur Head; Iodoacetates; Male; Membrane Potential, Mitochondrial; Mitochondria; Osteoarthritis; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2013 |
Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species‑mediated mitochondrial death pathway.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cytochromes c; Deoxyadenosines; Down-Regulation; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins; Male; Membrane Potential, Mitochondrial; Mitochondria; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2013 |
Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways.
Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Animals; Apoptosis; bcl-2-Associated X Protein; Caffeic Acids; Caspase 3; Cell Survival; Cyclooxygenase 2; Cytochromes c; Down-Regulation; Heme Oxygenase-1; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Succinates | 2013 |
Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Benzofurans; beta Catenin; Cadherins; Caspase 3; Caspase 9; Catalase; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coumarins; Cytochromes c; Enzyme Activation; Epithelial-Mesenchymal Transition; Humans; Male; Membrane Potential, Mitochondrial; Neoplasm Invasiveness; Oxidative Stress; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Reactive Oxygen Species; Snail Family Transcription Factors; Superoxide Dismutase; Superoxide Dismutase-1; Transcription Factors; Transcription, Genetic | 2014 |
Generation of reactive oxygen species by a novel berberine-bile acid analog mediates apoptosis in hepatocarcinoma SMMC-7721 cells.
Topics: Acetylcysteine; Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Berberine; Bile Acids and Salts; Calcium; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Cytosol; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membranes; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Time Factors | 2013 |
Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cytochromes c; Dose-Response Relationship, Drug; Flavones; Gene Expression Regulation; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Time Factors | 2014 |
CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction.
Topics: Acetylcysteine; Aged; Animals; Apoptosis; Cell Survival; Cytochromes c; Female; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; MCF-7 Cells; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Mitochondria; Naphthoquinones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Survivin; Vitamin K 3 | 2013 |
Zinc status alters growth and oxidative stress responses in rat hepatoma cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cytochromes c; Liver Neoplasms; Mitochondria; Oxidative Stress; Proto-Oncogene Proteins c-mdm2; Rats; Reactive Oxygen Species; Tumor Suppressor Protein p53; Zinc | 2014 |
Nuclear NF-κB contributes to chlorpyrifos-induced apoptosis through p53 signaling in human neural precursor cells.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cells, Cultured; Chlorpyrifos; Cytochromes c; Dose-Response Relationship, Drug; Humans; Insecticides; L-Lactate Dehydrogenase; Malondialdehyde; Neural Stem Cells; NF-kappa B; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Mono-(2-ethylhexyl) phthalate induces injury in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Caspases; Cell Survival; Cells, Cultured; Cytochromes c; Diethylhexyl Phthalate; Environmental Pollutants; Glutathione; Human Umbilical Vein Endothelial Cells; Humans; Malondialdehyde; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2014 |
High-dialysate-glucose-induced oxidative stress and mitochondrial-mediated apoptosis in human peritoneal mesothelial cells.
Topics: Acetylcysteine; Apoptosis; Caspases; Cells, Cultured; Cytochromes c; Dialysis Solutions; DNA Damage; Epithelial Cells; Glucose; Humans; Lipid Peroxidation; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Peritoneum; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species | 2014 |
PUMA is invovled in ischemia/reperfusion-induced apoptosis of mouse cerebral astrocytes.
Topics: Acetylcysteine; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Hypoxia; Cell Survival; Cells, Cultured; Cytochromes c; Free Radical Scavengers; Gene Knockdown Techniques; Glucose; Mice, Inbred C57BL; Reactive Oxygen Species; Reperfusion Injury; RNA, Small Interfering; Transfection; Tumor Suppressor Proteins | 2015 |
The Photosystem II D1-K238E mutation enhances electrical current production using cyanobacterial thylakoid membranes in a bio-photoelectrochemical cell.
Topics: Acetylcysteine; Bioelectric Energy Sources; Cytochromes c; Electrochemical Techniques; Electrodes; Hydrogen; Mutation; Oxidation-Reduction; Photochemical Processes; Photosystem II Protein Complex; Synechocystis; Thylakoids | 2015 |
Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cytochromes c; Down-Regulation; Free Radical Scavengers; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mesothelioma; Mesothelioma, Malignant; Mitochondria; Pemetrexed; Reactive Oxygen Species; Sirtuin 1 | 2015 |
The pyridone-annelated isoindigo (5'-Cl) induces apoptosis, dysregulation of mitochondria and formation of ROS in leukemic HL-60 cells.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspases; Cell Line, Tumor; Cytochromes c; HL-60 Cells; Humans; Indoles; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridones; Pyrrolidines; Reactive Oxygen Species; Thiocarbamates | 2015 |
Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; Ascorbic Acid; bcl-2-Associated X Protein; Cell Proliferation; Cells, Cultured; Cytochromes c; Drug Synergism; Dynamins; GTP Phosphohydrolases; Histones; Humans; Hydrogen Peroxide; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Necrosis; Oxidative Stress; Protective Agents; Proto-Oncogene Proteins c-bcl-2 | 2015 |
Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Caspases; Cytochromes c; DNA Fragmentation; Down-Regulation; Humans; Membrane Potential, Mitochondrial; Phospholipases A; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Triterpenes; Up-Regulation; Urinary Bladder Neoplasms | 2015 |
The effect of treadmill training and N-acetyl-l-cysteine intervention on biogenesis of cytochrome c oxidase (COX).
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Cytochromes c; Electron Transport Complex IV; Male; Mice; Mitochondria; Oxidative Stress; Physical Conditioning, Animal; RNA, Messenger | 2015 |
The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; Averrhoa; Bone Neoplasms; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclohexenes; Cytochromes c; Drug Screening Assays, Antitumor; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Lung Neoplasms; MCF-7 Cells; NF-kappa B; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2015 |
Effects of N-acetylcysteine and L-arginine in the antioxidant system of C2C12 cells.
Topics: Acetylcysteine; Arginine; Cell Line; Cytochromes c; Dietary Supplements; Free Radical Scavengers; Humans; Muscle Cells | 2015 |
Induction of reactive oxygen species-mediated apoptosis by purified Schisandrae semen essential oil in human leukemia U937 cells through activation of the caspase cascades and nuclear relocation of mitochondrial apoptogenic factors.
Topics: Acetylcysteine; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Nucleus; Cell Survival; Cytochromes c; Endodeoxyribonucleases; Enzyme Activation; Humans; Mitochondria; Oils, Volatile; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Schisandra; U937 Cells | 2015 |
Oridonin Inhibits Cell Proliferation and Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Arthritis, Rheumatoid; Caspase 3; Caspase 9; Cell Line; Cell Proliferation; Cell Survival; Cytochromes c; Diterpenes, Kaurane; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Synoviocytes | 2016 |
Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Calcium; Caspase 3; Caspase 9; Cytochromes c; DNA Fragmentation; Down-Regulation; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Hot Temperature; Humans; Leishmania; Membrane Potential, Mitochondrial; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Tumor Suppressor Protein p53; Up-Regulation | 2016 |
Inhibition of the mitochondrial unfolded protein response by acetylcholine alleviated hypoxia/reoxygenation-induced apoptosis of endothelial cells.
Topics: Acetylcholine; Acetylcysteine; Apoptosis; ATP-Dependent Proteases; Cell Hypoxia; Chaperonin 60; Cytochromes c; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Proteins; Reactive Oxygen Species; Receptor, Muscarinic M3; RNA Interference; RNA, Small Interfering; Signal Transduction; Unfolded Protein Response; Up-Regulation | 2016 |
Anti-proliferative Effect of Physcion on Human Gastric Cell Line via Inducing ROS-Dependent Apoptosis.
Topics: Acetylcysteine; AMP-Activated Protein Kinases; Apoptosis; Blotting, Western; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Emodin; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Reactive Oxygen Species; Signal Transduction; Stomach Neoplasms | 2015 |
N-Acetyl-L-cysteine Protects the Enterocyte against Oxidative Damage by Modulation of Mitochondrial Function.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-X Protein; Caspase 3; Cell Proliferation; Cell Survival; Cytochromes c; DNA; Enterocytes; Flow Cytometry; Free Radical Scavengers; Hydrogen Peroxide; Mitochondria; Oxidative Stress; Swine | 2016 |
Nickel sulfate induced apoptosis via activating ROS-dependent mitochondria and endoplasmic reticulum stress pathways in rat Leydig cells.
Topics: Acetylcysteine; Animals; Apoptosis; Caspase 12; Caspase 3; Caspase 9; Cyclic N-Oxides; Cytochromes c; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Leydig Cells; Male; Mitochondria; Nickel; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Transcription Factor CHOP | 2017 |
Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Epithelial Cells; Free Radical Scavengers; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Thymol; Urothelium | 2017 |
α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties.
Topics: Acetylcysteine; Aldehydes; Antioxidants; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cytochromes c; DNA Fragmentation; Glutathione; Glutathione Reductase; Humans; Ketones; Membrane Potential, Mitochondrial; Neurons; Polyethylene Glycols; Pyrrolidines; Reactive Oxygen Species | 2017 |
Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells.
Topics: Acetylcysteine; Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromosomes; Cladosporium; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Microtubules; Naphthols; Reactive Oxygen Species | 2017 |
Non-thermal plasma induces mitochondria-mediated apoptotic signaling pathway via ROS generation in HeLa cells.
Topics: Acetylcysteine; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Proliferation; Cytochromes c; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Mitochondria; Plasma Gases; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Signal Transduction | 2017 |
N‑acetylcysteine induces apoptosis via the mitochondria‑dependent pathway but not via endoplasmic reticulum stress in H9c2 cells.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cell Line; Cytochromes c; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glutathione; Membrane Potential, Mitochondrial; Mitochondria; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Signal Transduction; Transcription Factor CHOP | 2017 |
Study on the effect of reactive oxygen species-mediated oxidative stress on the activation of mitochondrial apoptosis and the tenderness of yak meat.
Topics: Acetylcysteine; Animals; Apoptosis; Calcium; Catalase; Cattle; Cytochromes c; Food Quality; Glutathione Peroxidase; Hydrogen Peroxide; Male; Meat; Membrane Potential, Mitochondrial; Mitochondria, Muscle; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Superoxide Dismutase | 2018 |
Regulation of TBBPA-induced oxidative stress on mitochondrial apoptosis in L02 cells through the Nrf2 signaling pathway.
Topics: Acetylcysteine; Apoptosis; Caspase 3; Caspase 9; Catalase; Cell Line; Cytochromes c; Flame Retardants; Glutathione; Heme Oxygenase-1; Hepatocytes; Humans; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Polybrominated Biphenyls; Reactive Oxygen Species; Signal Transduction | 2019 |
α-Mangostin promotes apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes by reactive oxygen species-dependent activation of ERK1/2 mitogen-activated protein kinase.
Topics: Acetylcysteine; Aged; Apoptosis; Arthritis, Rheumatoid; Benzamides; Caspase 3; Caspase 9; Cell Survival; Cytochromes c; Female; Humans; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Reactive Oxygen Species; Sulfonamides; Synoviocytes; Xanthones | 2019 |
High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells.
Topics: Acetylcysteine; Aniline Compounds; Animals; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Complement C5a; Cytochromes c; Dose-Response Relationship, Drug; Endothelial Cells; Free Radical Scavengers; Humans; Kidney; Mice; Mitochondria; Reactive Oxygen Species; Receptor, Anaphylatoxin C5a; Recombinant Proteins; Tetrahydronaphthalenes | 2019 |
Raddeanin A suppresses lung cancer cell proliferation via induction of apoptosis and increased production of ROS.
Topics: Acetylcysteine; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Saponins | 2020 |
Effect of N-acetylcysteine on attenuation of chlropyrifos and its methyl analogue toxicity in male rats.
Topics: Acetylcysteine; Animals; Calcium; Chlorpyrifos; Cholinesterase Inhibitors; Chromosome Aberrations; Cytochromes c; Erythrocytes; Lipid Peroxidation; Male; Mutagenicity Tests; Nitric Oxide; Pesticides; Rats | 2021 |
N-Acetyl Cysteine, Selenium, and Ascorbic Acid Rescue Diabetic Cardiac Hypertrophy via Mitochondrial-Associated Redox Regulators.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Ascorbic Acid; Biomarkers; Blood Glucose; Body Weight; Calcium; Cardiomegaly; Cardiotonic Agents; Cytochromes c; Diabetic Cardiomyopathies; Disease Models, Animal; Down-Regulation; GATA4 Transcription Factor; Lipid Peroxidation; Lipids; Mitochondria, Heart; Myocardium; Oxidation-Reduction; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Selenium | 2021 |